SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing WP_011390757.1 NCBI__GCF_000013085.1:WP_011390757.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

5g4jA Phospholyase a1rdf1 from arthrobacter in complex with phosphoethanolamine (see paper)
45% identity, 94% coverage: 25:441/443 of query aligns to 2:421/423 of 5g4jA

query
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5g4jA

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active site: S14 (= S37), Y130 (= Y153), D201 (= D221), D234 (= D254), Q237 (= Q257), K264 (= K284), T294 (= T314), K395 (= K415)
binding {5-hydroxy-6-methyl-4-[(E)-{[2-(phosphonooxy)ethyl]imino}methyl]pyridin-3-yl}methyl dihydrogen phosphate: Y44 (= Y67), R73 (= R96), G103 (= G126), S104 (= S127), Y130 (= Y153), H131 (= H154), D234 (= D254), V236 (= V256), Q237 (= Q257), K264 (= K284), T294 (= T314), R397 (= R417)

5g4iA Plp-dependent phospholyase a1rdf1 from arthrobacter aurescens tc1 (see paper)
45% identity, 94% coverage: 25:441/443 of query aligns to 2:421/423 of 5g4iA

query
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5g4iA

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active site: S14 (= S37), Y130 (= Y153), D201 (= D221), D234 (= D254), Q237 (= Q257), K264 (= K284), T294 (= T314), K395 (= K415)
binding pyridoxal-5'-phosphate: G103 (= G126), S104 (= S127), H131 (= H154), D234 (= D254), V236 (= V256), Q237 (= Q257), K264 (= K284)
binding phosphate ion: Y44 (= Y67), R397 (= R417)

6torB Human o-phosphoethanolamine phospho-lyase (see paper)
44% identity, 89% coverage: 45:439/443 of query aligns to 1:395/404 of 6torB

query
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6torB

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active site: Y109 (= Y153), D212 (= D254), K244 (= K284)
binding 4'-deoxy-4'-aminopyridoxal-5'-phosphate: S81 (≠ T125), G82 (= G126), S83 (= S127), Y109 (= Y153), H110 (= H154), H112 (≠ N156), D212 (= D254), Q215 (= Q257)

5wyaA Structure of amino acid racemase, 2.65 a (see paper)
30% identity, 95% coverage: 20:441/443 of query aligns to 3:432/439 of 5wyaA

query
sites
5wyaA

D

D

S

K

A

A

Q

S

R

K

L

L

L

I

A

D

K

E

R

E

K

N

A

K

L

Y

F

Y

G

A

-

R

A

S

A
|
A

S

R

V

I

L

N

F

Y

Y

Y

D

N

K

-

P

-

L

L

E

V

L

I

V

D

R

H

A

A

E

H

G

G

C

A

W

T

L

L

F

V

D

D

E

V

A

D

G

G

E

N

R

K

Y

Y

L

I

D

D

V

L

Y

L

N

A

N

S

V
x
A

P

S

-

A

-

I

S

N

V

V

G

G

H

H

C

T

H

H

P

E

H

K

V

V

A

K

A

A

V

I

A

A

D

D

Q

Q

L

A

A

Q

K

K

I

L

N

I

T

H

H

Y

T

T

-

P

R

A

Y
|
Y

L

F

N

H

E

H

A

V

I

P

H

G

R

M

Y

E

A

L

E

S

R

E

L

K

V

L

A

A

T

K

L

I

P

A

P

P

-

G

-

N

S

S

L

P

S

K

N

M

I

V

T

S

F

F

T

G

C

N

T
x
S

G
|
G

S
|
S

E

D

S

A

N

N

D

D

L

A

A

I

L

I

R

K

L

F

A

A

S

R

H

A

Y

Y

S

T

G

G

G

R

R

Q

G

Y

V

I

I

V

V

S

T

Y

E

M

T

G

A

S

Y
|
Y

H
|
H

G

G

N

S

T

T

A

Y

A

G

V

S

T

Q

E

T

V

L

S

S

P

G

S

S

-

L

-

N

-

M

-

T

A

R

R

K

D

I

H

G

A

P

L

M

A

L

P

P

H

S

V

V

R

V

V

H

V

V

R

P

A

Y

P

P

D

D

S

S

Y

Y

R

R

V

T

A

Y

P

P

-

G

-

E

-

T

-

E

E

H

A

D

L

V

A

S

A

L

R

R

F

Y

A

F

G

N

D

E

V

F

A

K

A

P

I

F

A

E

D

S

L

F

A

L

D

P

H

A

G

D

I

E

T

T

L

-

S

A

A

C

L

V

L

L

V

I

D
x
E

S

P

I

I

F

Q

S

G

S

D

D

G

G

G

V

I

Y

I

A

K

D

A

P

P

A

E

G

E

F

Y

L

M

A

Q

E

L

A

V

V

Y

A

K

V

F

V

C

H

H

R

E

H

H

G

G

G

I

L

L

F

F

I

A

A

I

D
|
D

E

E

V
|
V

Q
x
N

P

Q

G

G

F

L

G

G

R

R

T

T

G

G

S

K

A

-

L

M

W

W

G

A

F

I

Q

Q

R

Q

-

F

H

K

G

D

V

I

T

E

P

P

D

D

I

L

V

M

T

S

M

V

G

G

K
|
K

P

S

M

L

G

A

N

S

G

G

L

M

P

P

M

L

G

S

G

A

V

V

A

I

T

G

R

K

P

K

E

E

I

V

L

M

D

Q

A

S

F

L

C

D

A

A

E

P

V

A

G

H

Y

L

F
|
F

N
x
T

T

T

F

-

G

A

G

G

S

N

P

P

A

V

A

C

G

S

A

A

G

S

S

L

A

A

V

T

L

L

D

D

V

V

I

I

E

E

G

Y

E

E

G

G

L

L

M

V

A

E

N

K

A

S

E

A

A

T

V

D

G

G

A

A

Y

Y

L

A

R

K

E

Q

S

R

L

F

G

L

A

E

L

M

A

Q

K

Q

R

R

F

H

P

P

V

M

I

I

G

G

D

D

V

V

R

R

G

M

A

W

G

G

L

L

F

N

D

G

A

G

V

I

E

E

L

L

V

V

S

K

D

D

P

P

E

K

A

T

K

K

T

E

P

P

S

D

P

S

E

D

L

A

A

A

S

T

A

K

I

V

I

I

N

Y

G

Y

L

A

R

F

Q

A

R

H

H

G

V

V

L

V

I

I

G

I

A

T

A

L

G

A

P

-

F

-

G

G

N

N

I

I

L

L

K
x
R

V

F

R

Q

P

P

L

L

C

V

F

I

T

P

R

R

D

E

Q

Q

V

L

D

D

I

Q

L

A

G

L

A

Q

A

V

L

L

E

D

V

A

L

F

T

T

E

A

I

V

active site: A20 (= A36), Y140 (= Y153), E215 (≠ D221), D248 (= D254), N251 (≠ Q257), K278 (= K284), T307 (≠ N313), R406 (≠ K415)
binding (2S,3S)-3-methyl-2-[[2-methyl-3-oxidanyl-5-(phosphonooxymethyl)pyridin-4-yl]methylamino]pentanoic acid: A52 (≠ V70), Y82 (= Y97), S112 (≠ T125), G113 (= G126), S114 (= S127), Y140 (= Y153), H141 (= H154), E215 (≠ D221), D248 (= D254), V250 (= V256), N251 (≠ Q257), K278 (= K284), F306 (= F312), T307 (≠ N313), R406 (≠ K415)

4ysnC Structure of aminoacid racemase in complex with plp (see paper)
30% identity, 95% coverage: 20:441/443 of query aligns to 12:441/448 of 4ysnC

query
sites
4ysnC

D

D

S

K

A

A

Q

S

R

K

L

L

L

I

A

D

K

E

R

E

K

N

A

K

L

Y

F

Y

G

A

-

R

A

S

A
|
A

S

R

V

I

L

N

F

Y

Y

Y

D

N

K

-

P

-

L

L

E

V

L

I

V

D

R

H

A

A

E

H

G

G

C

A

W

T

L

L

F

V

D

D

E

V

A

D

G

G

E

N

R

K

Y

Y

L

I

D

D

V

L

Y

L

N

A

N

S

V

A

P

S

-

A

-

I

S

N

V

V

G

G

H

H

C

T

H

H

P

E

H

K

V

V

A

K

A

A

V

I

A

A

D

D

Q

Q

L

A

A

Q

K

K

I

L

N

I

T

H

H

Y

T

T

-

P

R

A

Y

Y

L

F

N

H

E

H

A

V

I

P

H

G

R

M

Y

E

A

L

E

S

R

E

L

K

V

L

A

A

T

K

L

I

P

A

P

P

-

G

-

N

S

S

L

P

S

K

N

M

I

V

T

S

F

F

T

G

C

N

T
x
S

G
|
G

S
|
S

E

D

S

A

N

N

D

D

L

A

A

I

L

I

R

K

L

F

A

A

S

R

H

A

Y

Y

S

T

G

G

G

R

R

Q

G

Y

V

I

I

V

V

S

T

Y

E

M

T

G

A

S

Y
|
Y

H
|
H

G

G

N

S

T

T

A

Y

A

G

V

S

T

Q

E

T

V

L

S

S

P

G

S

S

-

L

-

N

-

M

-

T

A

R

R

K

D

I

H

G

A

P

L

M

A

L

P

P

H

S

V

V

R

V

V

H

V

V

R

P

A

Y

P

P

D

D

S

S

Y

Y

R

R

V

T

A

Y

P

P

-

G

-

E

-

T

-

E

E

H

A

D

L

V

A

S

A

L

R

R

F

Y

A

F

G

N

D

E

V

F

A

K

A

P

I

F

A

E

D

S

L

F

A

L

D

P

H

A

G

D

I

E

T

T

L

-

S

A

A

C

L

V

L

L

V

I

D
x
E

S

P

I

I

F

Q

S

G

S

D

D

G

G

G

V

I

Y

I

A

K

D

A

P

P

A

E

G

E

F

Y

L

M

A

Q

E

L

A

V

V

Y

A

K

V

F

V

C

H

H

R

E

H

H

G

G

G

I

L

L

F

F

I

A

A

I

D
|
D

E

E

V
|
V

Q
x
N

P

Q

G

G

F

L

G

G

R

R

T

T

G

G

S

K

A

-

L

M

W

W

G

A

F

I

Q

Q

R

Q

-

F

H

K

G

D

V

I

T

E

P

P

D

D

I

L

V

M

T

S

M

V

G

G

K
|
K

P

S

M

L

G

A

N

S

G

G

L

M

P

P

M

L

G

S

G

A

V

V

A

I

T

G

R

K

P

K

E

E

I

V

L

M

D

Q

A

S

F

L

C

D

A

A

E

P

V

A

G

H

Y

L

F
|
F

N
x
T

T

T

F

-

G

A

G

G

S

N

P

P

A

V

A

C

G

S

A

A

G

S

S

L

A

A

V

T

L

L

D

D

V

V

I

I

E

E

G

Y

E

E

G

G

L

L

M

V

A

E

N

K

A

S

E

A

A

T

V

D

G

G

A

A

Y

Y

L

A

R

K

E

Q

S

R

L

F

G

L

A

E

L

M

A

Q

K

Q

R

R

F

H

P

P

V

M

I

I

G

G

D

D

V

V

R

R

G

M

A

W

G

G

L

L

F

N

D

G

A

G

V

I

E

E

L

L

V

V

S

K

D

D

P

P

E

K

A

T

K

K

T

E

P

P

S

D

P

S

E

D

L

A

A

A

S

T

A

K

I

V

I

I

N

Y

G

Y

L

A

R

F

Q

A

R

H

H

G

V

V

L

V

I

I

G

I

A

T

A

L

G

A

P

-

F

-

G

G

N

N

I

I

L

L

K
x
R

V

F

R

Q

P

P

L

L

C

V

F

I

T

P

R

R

D

E

Q

Q

V

L

D

D

I

Q

L

A

G

L

A

Q

A

V

L

L

E

D

V

A

L

F

T

T

E

A

I

V

active site: A29 (= A36), Y149 (= Y153), E224 (≠ D221), D257 (= D254), N260 (≠ Q257), K287 (= K284), T316 (≠ N313), R415 (≠ K415)
binding pyridoxal-5'-phosphate: S121 (≠ T125), G122 (= G126), S123 (= S127), Y149 (= Y153), H150 (= H154), E224 (≠ D221), D257 (= D254), V259 (= V256), K287 (= K284), F315 (= F312), T316 (≠ N313)

5wyfA Structure of amino acid racemase, 2.12 a (see paper)
30% identity, 95% coverage: 20:441/443 of query aligns to 5:434/446 of 5wyfA

query
sites
5wyfA

D

D

S

K

A

A

Q

S

R

K

L

L

L

I

A

D

K

E

R

E

K

N

A

K

L

Y

F

Y

G

A

-

R

A

S

A
|
A

S

R

V

I

L

N

F

Y

Y

Y

D

N

K

-

P

-

L

L

E

V

L

I

V

D

R

H

A

A

E

H

G

G

C

A

W

T

L

L

F

V

D

D

E

V

A

D

G

G

E

N

R

K

Y

Y

L

I

D

D

V

L

Y

L

N

A

N

S

V
x
A

P

S

-

A

-

I

S

N

V

V

G

G

H

H

C

T

H

H

P

E

H

K

V

V

A

K

A

A

V

I

A

A

D

D

Q

Q

L

A

A

Q

K

K

I

L

N

I

T

H

H

Y

T

T

-

P

R

A

Y
|
Y

L

F

N

H

E

H

A

V

I

P

H

G

R

M

Y

E

A

L

E

S

R

E

L

K

V

L

A

A

T

K

L

I

P

A

P

P

-

G

-

N

S

S

L

P

S

K

N

M

I

V

T

S

F

F

T

G

C

N

T

S

G
|
G

S
|
S

E

D

S

A

N

N

D

D

L

A

A

I

L

I

R

K

L

F

A

A

S

R

H

A

Y

Y

S

T

G

G

G

R

R

Q

G

Y

V

I

I

V

V

S

T

Y

E

M

T

G

A

S

Y
|
Y

H
|
H

G

G

N

S

T

T

A

Y

A

G

V

S

T

Q

E

T

V

L

S

S

P

G

S

S

-

L

-

N

-

M

-

T

A

R

R

K

D

I

H

G

A

P

L

M

A

L

P

P

H

S

V

V

R

V

V

H

V

V

R

P

A

Y

P

P

D

D

S

S

Y

Y

R

R

V

T

A

Y

P

P

-

G

-

E

-

T

-

E

E

H

A

D

L

V

A

S

A

L

R

R

F

Y

A

F

G

N

D

E

V

F

A

K

A

P

I

F

A

E

D

S

L

F

A

L

D

P

H

A

G

D

I

E

T

T

L

-

S

A

A

C

L

V

L

L

V

I

D
x
E

S

P

I

I

F

Q

S

G

S
x
D

D

G

G

G

V

I

Y

I

A

K

D

A

P

P

A

E

G

E

F

Y

L

M

A

Q

E

L

A

V

V

Y

A

K

V

F

V

C

H

H

R

E

H

H

G

G

G

I

L

L

F

F

I

A

A

I

D
|
D

E

E

V
|
V

Q
x
N

P

Q

G

G

F

L

G

G

R

R

T

T

G

G

S

K

A

-

L

M

W

W

G

A

F

I

Q

Q

R

Q

-

F

H

K

G

D

V

I

T

E

P

P

D

D

I

L

V

M

T

S

M

V

G

G

K
|
K

P

S

M

L

G

A

N

S

G

G

L

M

P

P

M

L

G

S

G

A

V

V

A

I

T

G

R

K

P

K

E

E

I

V

L

M

D

Q

A

S

F

L

C

D

A

A

E

P

V

A

G

H

Y

L

F
|
F

N
x
T

T

T

F

-

G

A

G

G

S

N

P

P

A

V

A

C

G

S

A

A

G

S

S

L

A

A

V

T

L

L

D

D

V

V

I

I

E

E

G

Y

E

E

G

G

L

L

M

V

A

E

N

K

A

S

E

A

A

T

V

D

G

G

A

A

Y

Y

L

A

R

K

E

Q

S

R

L

F

G

L

A

E

L

M

A

Q

K

Q

R

R

F

H

P

P

V

M

I

I

G

G

D

D

V

V

R

R

G

M

A

W

G

G

L

L

F

N

D

G

A

G

V

I

E

E

L

L

V

V

S

K

D

D

P

P

E

K

A

T

K

K

T

E

P

P

S

D

P

S

E

D

L

A

A

A

S

T

A

K

I

V

I

I

N

Y

G

Y

L

A

R

F

Q

A

R

H

H

G

V

V

L

V

I

I

G

I

A

T

A

L

G

A

P

-

F

-

G

G

N

N

I

I

L

L

K
x
R

V

F

R

Q

P

P

L

L

C

V

F

I

T

P

R

R

D

E

Q

Q

V

L

D

D

I

Q

L

A

G

L

A

Q

A

V

L

L

E

D

V

A

L

F

T

T

E

A

I

V

active site: A22 (= A36), Y142 (= Y153), E217 (≠ D221), D250 (= D254), N253 (≠ Q257), K280 (= K284), T309 (≠ N313), R408 (≠ K415)
binding n-[o-phosphono-pyridoxyl]-isoleucine: A54 (≠ V70), Y84 (= Y97), G115 (= G126), S116 (= S127), Y142 (= Y153), H143 (= H154), D222 (≠ S226), D250 (= D254), V252 (= V256), N253 (≠ Q257), K280 (= K284), F308 (= F312), T309 (≠ N313), R408 (≠ K415)

1zobA Crystal structure of dialkylglycine decarboxylases bound with calcium ion
33% identity, 89% coverage: 43:438/443 of query aligns to 23:431/431 of 1zobA

query
sites
1zobA

K

E

P

P

L

M

E

I

L

I

V

E

R

R

A

A

E

K

G

G

C

S

W

F

L

V

F

Y

D

D

E

A

A

D

G

G

E

R

R

A

Y

I

L

L

D

D

V

F

Y

T

N

S

N

G

V

Q

P

M

S

S

-

A

-

V

V

L

G

G

H

H

C

C

H

H

P

P

H

E

V

I

V

V

A

S

A

V

V

I

A

G

D

E

Q

Y

L

A

A

G

K

K

I

L

N

D

-

H

T
x
L

H

F

T
x
S

R

E

Y

M

L

L

N

S

E

R

A

P

I

V

H

V

R

D

Y

L

A

A

E

T

R

R

L

L

V

A

A

N

T

I

L

T

P

P

S

G

L

L

S

D

N

R

I

A

T

L

F

L

T

L

C

S

T
|
T

G

G

S
x
A

E

E

S

S

N
|
N

D

E

L

A

A

A

L

I

R

R

L

M

A

A

S

K

H

L

Y

V

S

T

G

G

G

K

R

Y

G

E

V

I

I

V

V

G

T

F

E

A

T

Q

A

S

Y
x
W

H
|
H

G

G

N

M

T

T

A

G

A

A

V

A

T

A

E

S

V

A

S

T

P

Y

S

S

S

A

A

G

R

R

D

K

H

G

A

V

L

G

A

P

P

A

H

A

V

V

R

G

-

S

-

F

V

A

V

I

R

P

A

A

P

P

D

F

S

T

Y

Y

R

R

V

P

A

R

P

F

E

E

A

R

L

N

A

G

A

A

R

Y

-

D

F

Y

A

L

G

A

D

E

V

L

A

D

A

Y

A

A

I

F

A

-

D

D

L

L

A

I

D

D

H

R

G

Q

I

S

T

S

-

G

-

N

L

L

S

A

A

A

L

F

L

I

V

A

D
x
E

S

P

I

I

F

L

S

S

D

G

G

G

V

I

Y

I

A

E

D

L

P

P

A

D

G

G

F

Y

L

M

A

A

E

A

A

L

V

K

A

R

V

K

V

C

H

E

R

A

H

R

G

G

G

M

L

L

F

L

I

I

A

L

D
|
D

E

E

V
x
A

Q
|
Q

P

T

G

G

F

V

G

G

R

R

T

T

G

G

S

T

A

-

L

M

W

F

G

A

F

C

Q

Q

R

R

H

D

G

G

V

V

T

T

P

P

D

D

I

I

V

L

T

T

M

L

G

S

K
|
K

P

T

M

L

G

G

N

A

G

G

L

L

P

P

M

L

G

A

V

I

A

V

T

T

R

S

P

A

E

A

I

I

L

-

D

E

A

E

F

R

C

A

A

H

E

E

V

L

G

G

Y

Y

-

L

-

F

F

Y

N

T

T
|
T

F

H

G
x
V

G
x
S

S
x
D

P

P

A

L

A

P

G

A

A

A

A

V

G

G

S

L

A

R

V

V

L

L

D

D

V

V

I

V

E

Q

G

R

E

D

G

G

L

L

M

V

A

A

N

R

A

A

E

N

A

V

V

M

G

G

A

D

Y

R

L

L

R

R

E

R

S

G

L

L

G

L

A

D

L

L

A

M

K

E

R

R

F

F

P

D

V

C

I

I

G

G

D

D

V

V

R

R

G

G

A

R

G

G

L

L

F

L

D

L

A

G

V

V

E

E

L

I

V

V

S

K

D

D

P

R

E

R

A

T

K

K

T

E

P

P

S

A

P

D

E

G

L

L

A

G

S

A

A

K

I

I

I

T

N

R

-

E

-

C

-

M

-

N

-

L

G

G

L

L

R

S

Q

M

R

N

H

I

V

V

L

Q

I

L

G

P

A

G

A

-

G

-

P

-

F

M

G

G

N

G

I

V

L

F

K
x
R

V

I

R

A

P

P

L

L

C

T

F

V

T

S

R

E

D

D

Q

E

V

I

D

D

-

L

-

G

-

L

-

S

I

L

L

L

G

G

A

Q

A

A

L

I

E

E

E

R

V

A

L

L

active site: W136 (≠ Y153), E208 (≠ D221), D241 (= D254), Q244 (= Q257), K270 (= K284), T301 (= T314), R404 (≠ K415)
binding calcium ion: L76 (≠ T93), S78 (≠ T95), V303 (≠ G316), S304 (≠ G317), D305 (≠ S318)
binding pyridoxal-5'-phosphate: T108 (= T125), A110 (≠ S127), N113 (= N130), W136 (≠ Y153), H137 (= H154), E208 (≠ D221), D241 (= D254), A243 (≠ V256), Q244 (= Q257), K270 (= K284)

Sites not aligning to the query:

active site: 19

1zc9A The crystal structure of dialkylglycine decarboxylase complex with pyridoxamine 5-phosphate (see paper)
33% identity, 89% coverage: 43:438/443 of query aligns to 23:431/431 of 1zc9A

query
sites
1zc9A

K

E

P

P

L

M

E

I

L

I

V

E

R

R

A

A

E

K

G

G

C

S

W

F

L

V

F

Y

D

D

E

A

A

D

G

G

E

R

R

A

Y

I

L

L

D

D

V

F

Y

T

N

S

N

G

V

Q

P

M

S

S

-

A

-

V

V

L

G

G

H

H

C

C

H

H

P

P

H

E

V

I

V

V

A

S

A

V

V

I

A

G

D

E

Q

Y

L

A

A

G

K

K

I

L

N

D

-

H

T

L

H

F

T

S

R

E

Y

M

L

L

N

S

E

R

A

P

I

V

H

V

R

D

Y

L

A

A

E

T

R

R

L

L

V

A

A

N

T

I

L

T

P

P

S

G

L

L

S

D

N

R

I

A

T

L

F

L

T

L

C

S

T

T

G
|
G

S
x
A

E

E

S

S

N

N

D

E

L

A

A

A

L

I

R

R

L

M

A

A

S

K

H

L

Y

V

S

T

G

G

G

K

R

Y

G

E

V

I

I

V

V

G

T

F

E

A

T

Q

A

S

Y
x
W

H
|
H

G

G

N

M

T

T

A

G

A

A

V

A

T

A

E

S

V

A

S

T

P

Y

S

S

S

A

A

G

R

R

D

K

H

G

A

V

L

G

A

P

P

A

H

A

V

V

R

G

-

S

-

F

V

A

V

I

R

P

A

A

P

P

D

F

S

T

Y

Y

R

R

V

P

A

R

P

F

E

E

A

R

L

N

A

G

A

A

R

Y

-

D

F

Y

A

L

G

A

D

E

V

L

A

D

A

Y

A

A

I

F

A

-

D

D

L

L

A

I

D

D

H

R

G

Q

I

S

T

S

-

G

-

N

L

L

S

A

A

A

L

F

L

I

V

A

D
x
E

S

P

I

I

F

L

S

S

D

G

G

G

V

I

Y

I

A

E

D

L

P

P

A

D

G

G

F

Y

L

M

A

A

E

A

A

L

V

K

A

R

V

K

V

C

H

E

R

A

H

R

G

G

G

M

L

L

F

L

I

I

A

L

D
|
D

E

E

V
x
A

Q
|
Q

P

T

G

G

F

V

G

G

R

R

T

T

G

G

S

T

A

-

L

M

W

F

G

A

F

C

Q

Q

R

R

H

D

G

G

V

V

T

T

P

P

D

D

I

I

V

L

T

T

M

L

G

S

K
|
K

P

T

M

L

G

G

N

A

G

G

L

L

P

P

M

L

G

A

V

I

A

V

T

T

R

S

P

A

E

A

I

I

L

-

D

E

A

E

F

R

C

A

A

H

E

E

V

L

G

G

Y

Y

-

L

-

F

F

Y

N

T

T
|
T

F

H

G

V

G

S

S

D

P

P

A

L

A

P

G

A

A

A

A

V

G

G

S

L

A

R

V

V

L

L

D

D

V

V

I

V

E

Q

G

R

E

D

G

G

L

L

M

V

A

A

N

R

A

A

E

N

A

V

V

M

G

G

A

D

Y

R

L

L

R

R

E

R

S

G

L

L

G

L

A

D

L

L

A

M

K

E

R

R

F

F

P

D

V

C

I

I

G

G

D

D

V

V

R

R

G

G

A

R

G

G

L

L

F

L

D

L

A

G

V

V

E

E

L

I

V

V

S

K

D

D

P

R

E

R

A

T

K

K

T

E

P

P

S

A

P

D

E

G

L

L

A

G

S

A

A

K

I

I

I

T

N

R

-

E

-

C

-

M

-

N

-

L

G

G

L

L

R

S

Q

M

R

N

H

I

V

V

L

Q

I

L

G

P

A

G

A

-

G

-

P

-

F

M

G

G

N

G

I

V

L

F

K
x
R

V

I

R

A

P

P

L

L

C

T

F

V

T

S

R

E

D

D

Q

E

V

I

D

D

-

L

-

G

-

L

-

S

I

L

L

L

G

G

A

Q

A

A

L

I

E

E

E

R

V

A

L

L

active site: W136 (≠ Y153), E208 (≠ D221), D241 (= D254), Q244 (= Q257), K270 (= K284), T301 (= T314), R404 (≠ K415)
binding 4'-deoxy-4'-aminopyridoxal-5'-phosphate: G109 (= G126), A110 (≠ S127), W136 (≠ Y153), H137 (= H154), E208 (≠ D221), D241 (= D254), A243 (≠ V256), Q244 (= Q257), K270 (= K284)

Sites not aligning to the query:

active site: 19

1m0qA Structure of dialkylglycine decarboxylase complexed with s-1- aminoethanephosphonate (see paper)
33% identity, 89% coverage: 43:438/443 of query aligns to 23:431/431 of 1m0qA

query
sites
1m0qA

K

E

P

P

L

M

E

I

L

I

V

E

R

R

A

A

E

K

G

G

C

S

W

F

L

V

F

Y

D

D

E

A

A

D

G

G

E

R

R

A

Y

I

L

L

D

D

V

F

Y

T

N

S

N

G

V
x
Q

P

M

S

S

-

A

-

V

V

L

G

G

H

H

C

C

H

H

P

P

H

E

V

I

V

V

A

S

A

V

V

I

A

G

D

E

Q

Y

L

A

A

G

K

K

I

L

N

D

-

H

T

L

H

F

T

S

R

E

Y

M

L

L

N

S

E

R

A

P

I

V

H

V

R

D

Y

L

A

A

E

T

R

R

L

L

V

A

A

N

T

I

L

T

P

P

S

G

L

L

S

D

N

R

I

A

T

L

F

L

T

L

C

S

T
|
T

G

G

S
x
A

E

E

S

S

N

N

D

E

L

A

A

A

L

I

R

R

L

M

A

A

S

K

H

L

Y

V

S

T

G

G

G

K

R

Y

G

E

V

I

I

V

V

G

T

F

E

A

T

Q

A

S

Y
x
W

H
|
H

G

G

N

M

T

T

A

G

A

A

V

A

T

A

E

S

V

A

S

T

P

Y

S

S

S

A

A

G

R

R

D

K

H

G

A

V

L

G

A

P

P

A

H

A

V

V

R

G

-

S

-

F

V

A

V

I

R

P

A

A

P

P

D

F

S

T

Y

Y

R

R

V

P

A

R

P

F

E

E

A

R

L

N

A

G

A

A

R

Y

-

D

F

Y

A

L

G

A

D

E

V

L

A

D

A

Y

A

A

I

F

A

-

D

D

L

L

A

I

D

D

H

R

G

Q

I

S

T

S

-

G

-

N

L

L

S

A

A

A

L

F

L

I

V

A

D
x
E

S

P

I

I

F

L

S

S

S
|
S

D

G

G

G

V

I

Y

I

A

E

D

L

P

P

A

D

G

G

F

Y

L

M

A

A

E

A

A

L

V

K

A

R

V

K

V

C

H

E

R

A

H

R

G

G

G

M

L

L

F

L

I

I

A

L

D
|
D

E

E

V
x
A

Q
|
Q

P

T

G

G

F

V

G

G

R

R

T

T

G

G

S

T

A

-

L

M

W

F

G

A

F

C

Q

Q

R

R

H

D

G

G

V

V

T

T

P

P

D

D

I

I

V

L

T

T

M

L

G

S

K
|
K

P

T

M

L

G

G

N

A

G

G

L

L

P

P

M

L

G

A

V

I

A

V

T

T

R

S

P

A

E

A

I

I

L

-

D

E

A

E

F

R

C

A

A

H

E

E

V

L

G

G

Y

Y

-

L

-

F

F

Y

N

T

T
|
T

F

H

G

V

G

S

S

D

P

P

A

L

A

P

G

A

A

A

A

V

G

G

S

L

A

R

V

V

L

L

D

D

V

V

I

V

E

Q

G

R

E

D

G

G

L

L

M

V

A

A

N

R

A

A

E

N

A

V

V

M

G

G

A

D

Y

R

L

L

R

R

E

R

S

G

L

L

G

L

A

D

L

L

A

M

K

E

R

R

F

F

P

D

V

C

I

I

G

G

D

D

V

V

R

R

G

G

A

R

G

G

L

L

F

L

D

L

A

G

V

V

E

E

L

I

V

V

S

K

D

D

P

R

E

R

A

T

K

K

T

E

P

P

S

A

P

D

E

G

L

L

A

G

S

A

A

K

I

I

I

T

N

R

-

E

-

C

-

M

-

N

-

L

G

G

L

L

R

S

Q

M

R

N

H

I

V

V

L

Q

I

L

G

P

A

G

A

-

G

-

P

-

F

M

G

G

N

G

I

V

L

F

K
x
R

V

I

R

A

P

P

L

L

C

T

F

V

T

S

R

E

D

D

Q

E

V

I

D

D

-

L

-

G

-

L

-

S

I

L

L

L

G

G

A

Q

A

A

L

I

E

E

E

R

V

A

L

L

active site: W136 (≠ Y153), E208 (≠ D221), D241 (= D254), Q244 (= Q257), K270 (= K284), T301 (= T314), R404 (≠ K415)
binding (1s)-1-[((1e)-{3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylene)amino]ethylphosphonic acid: Q50 (≠ V70), T108 (= T125), A110 (≠ S127), W136 (≠ Y153), H137 (= H154), E208 (≠ D221), S213 (= S226), D241 (= D254), A243 (≠ V256), Q244 (= Q257), K270 (= K284), R404 (≠ K415)

Sites not aligning to the query:

active site: 19

1m0pA Structure of dialkylglycine decarboxylase complexed with 1-amino-1- phenylethanephosphonate (see paper)
33% identity, 89% coverage: 43:438/443 of query aligns to 23:431/431 of 1m0pA

query
sites
1m0pA

K

E

P

P

L

M

E

I

L

I

V

E

R

R

A

A

E

K

G

G

C

S

W

F

L

V

F

Y

D

D

E

A

A

D

G

G

E

R

R

A

Y

I

L

L

D

D

V

F

Y

T

N

S

N

G

V
x
Q

P

M

S

S

-

A

-

V

V

L

G

G

H

H

C

C

H

H

P

P

H

E

V

I

V

V

A

S

A

V

V

I

A

G

D

E

Q

Y

L

A

A

G

K

K

I

L

N

D

-

H

T

L

H

F

T

S

R

E

Y

M

L

L

N

S

E

R

A

P

I

V

H

V

R

D

Y

L

A

A

E

T

R

R

L

L

V

A

A

N

T

I

L

T

P

P

S

G

L

L

S

D

N

R

I

A

T

L

F

L

T

L

C

S

T
|
T

G

G

S
x
A

E

E

S

S

N

N

D

E

L

A

A

A

L

I

R

R

L

M

A

A

S

K

H

L

Y

V

S

T

G

G

G

K

R

Y

G

E

V

I

I

V

V

G

T

F

E

A

T

Q

A

S

Y
x
W

H
|
H

G

G

N

M

T

T

A

G

A

A

V

A

T

A

E

S

V

A

S

T

P

Y

S

S

S

A

A

G

R

R

D

K

H

G

A

V

L

G

A

P

P

A

H

A

V

V

R

G

-

S

-

F

V

A

V

I

R

P

A

A

P

P

D

F

S

T

Y

Y

R

R

V

P

A

R

P

F

E

E

A

R

L

N

A

G

A

A

R

Y

-

D

F

Y

A

L

G

A

D

E

V

L

A

D

A

Y

A

A

I

F

A

-

D

D

L

L

A

I

D

D

H

R

G

Q

I

S

T

S

-

G

-

N

L

L

S

A

A

A

L

F

L

I

V

A

D
x
E

S

P

I

I

F

L

S

S

S
|
S

D

G

G

G

V

I

Y

I

A

E

D

L

P

P

A

D

G

G

F

Y

L

M

A

A

E

A

A

L

V

K

A

R

V

K

V

C

H

E

R

A

H

R

G

G

G

M

L

L

F

L

I

I

A

L

D
|
D

E

E

V
x
A

Q
|
Q

P

T

G

G

F

V

G

G

R

R

T

T

G

G

S

T

A

-

L

M

W

F

G

A

F

C

Q

Q

R

R

H

D

G

G

V

V

T

T

P

P

D

D

I

I

V

L

T

T

M

L

G

S

K
|
K

P

T

M

L

G

G

N

A

G

G

L

L

P

P

M

L

G

A

V

I

A

V

T

T

R

S

P

A

E

A

I

I

L

-

D

E

A

E

F

R

C

A

A

H

E

E

V

L

G

G

Y

Y

-

L

-

F

F

Y

N

T

T
|
T

F

H

G

V

G

S

S

D

P

P

A

L

A

P

G

A

A

A

A

V

G

G

S

L

A

R

V

V

L

L

D

D

V

V

I

V

E

Q

G

R

E

D

G

G

L

L

M

V

A

A

N

R

A

A

E

N

A

V

V

M

G

G

A

D

Y

R

L

L

R

R

E

R

S

G

L

L

G

L

A

D

L

L

A

M

K

E

R

R

F

F

P

D

V

C

I

I

G

G

D

D

V

V

R

R

G

G

A

R

G

G

L

L

F

L

D

L

A

G

V

V

E

E

L

I

V

V

S

K

D

D

P

R

E

R

A

T

K

K

T

E

P

P

S

A

P

D

E

G

L

L

A

G

S

A

A

K

I

I

I

T

N

R

-

E

-

C

-

M

-

N

-

L

G

G

L

L

R

S

Q

M

R

N

H

I

V

V

L

Q

I

L

G

P

A

G

A

-

G

-

P

-

F

M

G

G

N

G

I

V

L

F

K
x
R

V

I

R

A

P

P

L

L

C

T

F

V

T

S

R

E

D

D

Q

E

V

I

D

D

-

L

-

G

-

L

-

S

I

L

L

L

G

G

A

Q

A

A

L

I

E

E

E

R

V

A

L

L

active site: W136 (≠ Y153), E208 (≠ D221), D241 (= D254), Q244 (= Q257), K270 (= K284), T301 (= T314), R404 (≠ K415)
binding (1r)-1-[((1e)-{3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylene)amino]-1-phenylethylphosphonic acid: Q50 (≠ V70), T108 (= T125), A110 (≠ S127), W136 (≠ Y153), H137 (= H154), E208 (≠ D221), S213 (= S226), D241 (= D254), A243 (≠ V256), Q244 (= Q257), K270 (= K284), R404 (≠ K415)

Sites not aligning to the query:

active site: 19

1m0oA Structure of dialkylglycine decarboxylase complexed with 1-amino-1- methylpropanephosphonate (see paper)
33% identity, 89% coverage: 43:438/443 of query aligns to 23:431/431 of 1m0oA

query
sites
1m0oA

K

E

P

P

L

M

E

I

L

I

V

E

R

R

A

A

E

K

G

G

C

S

W

F

L

V

F

Y

D

D

E

A

A

D

G

G

E

R

R

A

Y

I

L

L

D

D

V

F

Y

T

N

S

N

G

V
x
Q

P

M

S

S

-

A

-

V

V

L

G

G

H

H

C

C

H

H

P

P

H

E

V

I

V

V

A

S

A

V

V

I

A

G

D

E

Q

Y

L

A

A

G

K

K

I

L

N

D

-

H

T

L

H

F

T

S

R

E

Y

M

L

L

N

S

E

R

A

P

I

V

H

V

R

D

Y

L

A

A

E

T

R

R

L

L

V

A

A

N

T

I

L

T

P

P

S

G

L

L

S

D

N

R

I

A

T

L

F

L

T

L

C

S

T

T

G
|
G

S
x
A

E

E

S

S

N

N

D

E

L

A

A

A

L

I

R

R

L

M

A

A

S

K

H

L

Y

V

S

T

G

G

G

K

R

Y

G

E

V

I

I

V

V

G

T

F

E

A

T

Q

A

S

Y
x
W

H
|
H

G

G

N

M

T

T

A

G

A

A

V

A

T

A

E

S

V

A

S

T

P

Y

S

S

S

A

A

G

R

R

D

K

H

G

A

V

L

G

A

P

P

A

H

A

V

V

R

G

-

S

-

F

V

A

V

I

R

P

A

A

P

P

D

F

S

T

Y

Y

R

R

V

P

A

R

P

F

E

E

A

R

L

N

A

G

A

A

R

Y

-

D

F

Y

A

L

G

A

D

E

V

L

A

D

A

Y

A

A

I

F

A

-

D

D

L

L

A

I

D

D

H

R

G

Q

I

S

T

S

-

G

-

N

L

L

S

A

A

A

L

F

L

I

V

A

D
x
E

S

P

I

I

F

L

S

S

D

G

G

G

V

I

Y

I

A

E

D

L

P

P

A

D

G

G

F

Y

L

M