SitesBLAST
Comparing WP_011425015.1 NCBI__GCF_000092045.1:WP_011425015.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
7w5nA The crystal structure of the reduced form of gluconobacter oxydans wsh-004 sndh (see paper)
50% identity, 96% coverage: 14:497/506 of query aligns to 7:490/492 of 7w5nA
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: W156 (= W164), K180 (= K188), A182 (≠ S190), T212 (= T220), G213 (= G221), G217 (= G225), F231 (= F239), G233 (= G241), S234 (= S242), V237 (= V245), Q337 (≠ H344), E388 (= E395), F390 (= F397)
7w5kA The c296a mutant of l-sorbosone dehydrogenase (sndh) from gluconobacter oxydans wsh-004 (see paper)
49% identity, 96% coverage: 14:497/506 of query aligns to 6:489/491 of 7w5kA
- binding nadp nicotinamide-adenine-dinucleotide phosphate: I152 (= I161), T153 (= T162), P154 (= P163), W155 (= W164), N156 (= N165), I161 (= I170), K179 (= K188), A181 (≠ S190), E182 (= E191), T211 (= T220), G212 (= G221), G216 (= G225), Q217 (≠ A226), F230 (= F239), T231 (= T240), G232 (= G241), S233 (= S242), V236 (= V245), E255 (= E263), L256 (= L264), G257 (= G265), A289 (≠ C297), E387 (= E395), F389 (= F397)
3u4jA Crystal structure of NAD-dependent aldehyde dehydrogenase from sinorhizobium meliloti
50% identity, 95% coverage: 18:498/506 of query aligns to 22:504/505 of 3u4jA
Sites not aligning to the query:
Q56YU0 Aldehyde dehydrogenase family 2 member C4; ALDH1a; Protein REDUCED EPIDERMAL FLUORESCENCE 1; EC 1.2.1.3 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
43% identity, 95% coverage: 19:499/506 of query aligns to 21:501/501 of Q56YU0
- G152 (= G148) mutation to E: In ref1-7; reduced activity on sinapaldehyde.
- G416 (≠ A412) mutation to R: In ref1-6; reduced activity on sinapaldehyde.
4pxlA Structure of zm aldh2-3 (rf2c) in complex with NAD (see paper)
42% identity, 94% coverage: 14:487/506 of query aligns to 2:476/486 of 4pxlA
- active site: N154 (= N165), K177 (= K188), E253 (= E263), C287 (= C297), E384 (= E395), D461 (≠ E472)
- binding nicotinamide-adenine-dinucleotide: I150 (= I161), V151 (≠ T162), P152 (= P163), W153 (= W164), K177 (= K188), E180 (= E191), G210 (= G221), G214 (= G225), A215 (= A226), F228 (= F239), G230 (= G241), S231 (= S242), V234 (= V245), E253 (= E263), G255 (= G265), C287 (= C297), Q334 (≠ H344), K337 (= K347), E384 (= E395), F386 (= F397)
5gtlA NADPH complex structure of aldehyde dehydrogenase from bacillus cereus
39% identity, 94% coverage: 16:491/506 of query aligns to 15:490/491 of 5gtlA
- active site: N165 (= N165), K188 (= K188), E263 (= E263), C297 (= C297), E394 (= E395), E471 (= E472)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: I161 (= I161), P163 (= P163), K188 (= K188), A190 (≠ S190), E191 (= E191), Q192 (≠ L192), G221 (= G221), G225 (= G225), G241 (= G241), S242 (= S242), T245 (≠ V245), L264 (= L264), C297 (= C297), E394 (= E395), F396 (= F397)
5gtkA NAD+ complex structure of aldehyde dehydrogenase from bacillus cereus
39% identity, 94% coverage: 16:491/506 of query aligns to 15:490/491 of 5gtkA
- active site: N165 (= N165), K188 (= K188), E263 (= E263), C297 (= C297), E394 (= E395), E471 (= E472)
- binding nicotinamide-adenine-dinucleotide: I161 (= I161), I162 (≠ T162), P163 (= P163), W164 (= W164), K188 (= K188), E191 (= E191), G221 (= G221), G225 (= G225), A226 (= A226), F239 (= F239), G241 (= G241), S242 (= S242), T245 (≠ V245), Y248 (≠ L248), L264 (= L264), C297 (= C297), Q344 (≠ H344), R347 (≠ K347), E394 (= E395), F396 (= F397)
P47895 Retinaldehyde dehydrogenase 3; RALDH-3; RalDH3; Aldehyde dehydrogenase 6; Aldehyde dehydrogenase family 1 member A3; ALDH1A3; EC 1.2.1.36 from Homo sapiens (Human) (see 2 papers)
39% identity, 97% coverage: 7:495/506 of query aligns to 21:511/512 of P47895
- R89 (≠ P73) to C: in MCOP8; does not affect ALDH1A3 expression; results in strongly reduced protein levels; dbSNP:rs397514652
- K204 (= K188) binding NAD(+)
- E207 (= E191) binding NAD(+)
- GSTEVG 257:262 (≠ GSTGVG 241:246) binding NAD(+)
- Q361 (≠ H344) binding NAD(+)
- E411 (= E395) binding NAD(+)
- A493 (= A477) to P: in MCOP8; does not affect ALDH1A3 expression; results in strongly reduced protein levels; dbSNP:rs397514653
Sites not aligning to the query:
- 1 modified: Initiator methionine, Removed
- 2 modified: N-acetylalanine
7qk9A Crystal structure of the aldh1a3-atp complex (see paper)
39% identity, 96% coverage: 7:492/506 of query aligns to 2:489/489 of 7qk9A
- binding adenosine-5'-triphosphate: I158 (= I161), T159 (= T162), P160 (= P163), W161 (= W164), K185 (= K188), E188 (= E191), G218 (= G221), G222 (= G225), F236 (= F239), S239 (= S242), V242 (= V245)
7a6qB Crystal structure of human aldehyde dehydrogenase 1a3 in complex with selective nr6 inhibitor compound (see paper)
39% identity, 96% coverage: 7:491/506 of query aligns to 3:489/489 of 7a6qB