SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing WP_011426214.1 NCBI__GCF_000092045.1:WP_011426214.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

O59010 Glutamate transporter homolog; Glt(Ph); Sodium-aspartate symporter Glt(Ph); Sodium-dependent aspartate transporter from Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) (see 3 papers)
32% identity, 90% coverage: 26:424/443 of query aligns to 21:425/425 of O59010

query
sites
O59010

V

I

L

L

A

G

A

A

I

I

A

V

A

-

G

G

I

L

L

I

L

L

G

G

H

H

F

Y

-

G

Y

Y

P

A

E

D

-

A

L

V

G

K

T

T

Q

Y

L

V

K

K

P

P

L

F

G

G

D

D

A

L

F

F

I

V

K

R

L

L

V

L

K

K

M

M

V

L

I

V

A

M

P

P

V

I

I

V

F

F

L

A

T
x
S

V

L

A

V

T

V

G

G

I

A

A

A

G

S

M

I

S

S

D

P

L

-

K

A

K

R

V

L

G

G

R

R

V

V

A

G

G

V

K

K

A

I

M

V

L

V

Y

Y

F

Y

L

L

T

L

F

T

S

S

T

A

L

F

A

A

L

V

V

T

I

L

G

G

M

I

I

I

V

M

A

A

N

R

V

L

V

F

Q

N

P

P

G

G

A

A

G

G

M

I

N

H

-

L

-

A

I

V

D

G

P

G

A

Q

S

Q

L

F

D

Q

P

P

K

K

A

-

V

-

A

-

T

-

F

-

A

-

D

-

K

-

A

-

H

Q

E

A

Q

P

S

P

I

L

V

V

G

K

F

I

L

L

T

L

N

D

I

I

I

V

P

P

T

T

T

N

I

P

V

F

G

G

A

A

F

L

A

A

D

N

G

G

D

Q

I

V

L

L

Q

P

V

T

L

I

F

F

S

A

V

I

L

I

F

L

G

G

I

I

A

A

L

I

A

T

M

Y

-

L

-

M

-

N

-

S

-

E

-

N

-

E

-

K

V

V

G

R

E

K

K

S

G

A

E

E

Q

T

V

L

T

D

F

A

L

I

N

N

A

G

L

L

T

A

A

E

P

A

I

M

F

Y

K

K

L

I

V

V

G

N

I

G

L

V

M

M

K

Q

A

Y

A

A

P

P

I

I

G

G

A

V

F

F

G

A

A

L

M

I

A

A

F

Y

T

V

I

M

G

A

K

E

Y

Q

G

G

I

V

G

K

S

V

I

V

A

G

N

E

L

L

A

A

M

K

L

V

I

T

G

A

T

A

F

V

Y

Y

I

V

T

G

S

L

L

T

L

L

F

Q

V

I

L

L

V

L

V

V

L

Y

G

F

A

V

V

L

A

L

R

K

Y

I

N

Y

G

G

F

I

S

D

I

P

L

I

A

S

L

F

L

I

R

K

Y

K

I

A

K

K

E

D

E

A

L

M

L

L

L

T

V

A

L

F

G

V

T

T

S
x
R

S
|
S

E

S

A

G

A

T

L

L

P

P

G

V

L

T

M

M

N

R

K

V

M

A

E

K

K

E

A

M

G

G

C

I

K

S

R

E

S

G

V

I

V

Y

G

S

L

F

V

T

I

L

P

P

T

L

G

G

Y

A

S

T

F

I

N

N

L
x
M

D

D

G

G

T
|
T

N

A

I

L

Y

Y

M

Q

T

G

L

V

A

C

A

T

L

F

F

F

I

I

A

A

Q

N

A

A

T

L

G

G

I

S

Q

H

L

L

S

T

W

V

G

G

D

Q

Q

Q

I

L

L

T

L

I

L

V

L

L

V

T

A

A

M

V

L

L

S

A

S

S

K

I

G

G

A

T

A

A

G

G

I
x
V

T

P

G

G

A

A

G

G

F

A

I

I

T

M

L

L

A

A

A

M

T

V

L

L

S

E

V

S

V

V

-

G

-

L

-

P

-

L

-

T

-

D

P

P

S

N

V

V

P

-

V

A

A

A

G

A

M

Y

A

A

L

M

I

I

L

L

G

G

I

I

D

D

R

A

F

I

M

L

S
x
D

E
x
M

C

G

R
|
R

A

T

L

M

T

V

N
|
N

L

V

V

T

G

G

N
x
D

A

L

V

T

A

G

T

T

I

A

V

I

V

V

A

A

R

K

W

T

E

E

N

G

E

E

L

L

D

E

T

K

G

G

Q

V

L

I

A

A

S65 (≠ T69) mutation to V: Strongly decreased chloride conductance.
R276 (≠ S280) mutation to S: Increased rate of aspartate transport; when associated with R-395.
RSS 276:278 (≠ SSS 280:282) binding L-aspartate
M311 (≠ L315) mutation to A: Decreased dependence of aspartate binding on Na(+) concentration.
T314 (= T318) binding L-aspartate
V355 (≠ I359) binding L-aspartate
D394 (≠ S393) binding L-aspartate
M395 (≠ E394) mutation to R: Increased rate of aspartate transport; when associated with S-276.
R397 (= R396) mutation to A: Strongly decreased affinity for aspartate.
N401 (= N400) binding L-aspartate
D405 (≠ N404) mutation to N: Strongly decreased affinity for aspartate.

2nwwA Crystal structure of gltph in complex with tboa (see paper)
32% identity, 86% coverage: 33:415/443 of query aligns to 18:407/407 of 2nwwA

query
sites
2nwwA

G

G

I

L

L

I

L

L

G

G

H

H

F

Y

-

G

Y

Y

P

A

E

H

-

A

L

V

G

H

T

T

Q

Y

L

V

K

K

P

P

L

F

G

G

D

D

A

L

F

F

I

V

K

R

L

L

V

L

K

K

M

M

V

L

I

V

A

M

P

P

V

I

I

V

F

F

L

A

T

S

V

L

A

V

T

V

G

G

I

A

A

A

G

S

M

I

S

S

D

P

L

-

K

A

K

R

V

L

G

G

R

R

V

V

A

G

G

V

K

K

A

I

M

V

L

V

Y

Y

F

Y

L

L

T

L

F

T

S

S

T

A

L

F

A

A

L

V

V

T

I

L

G

G

M

I

I

I

V

M

A

A

N

R

V

L

V

F

Q

N

P

P

G

G

A

A

G

G

M

I

N

H

I

L

D

-

P

-

A

-

S

-

L

-

D

-

P

-

K

-

A

A

V

V

A

G

T

G

F

Q

A

Q

D

F

K

Q

A

P

H

H

E

Q

-

A

Q

P

S

P

I

L

V

V

G

H

F

I

L

L

T

L

N

D

I

I

I

V

P

P

T

T

T

N

I

P

V

F

G

G

A

A

F

L

A

A

D

N

G

G

D

Q

I

V

L

L

Q

P

V

T

L

I

F

F

S

A

V

I

L

I

F

L

G

G

I

I

A

A

L

I

A

T

M

Y

-

L

-

M

-

N

-

S

-

E

-

N

-

E

-

K

V

V

G

R

E

K

K

S

G

A

E

E

Q

T

V

L

T

D

F

A

L

I

N

N

A

G

L

L

T

A

A

E

P

A

I

M

F

Y

K

K

L

I

V

V

G

N

I

G

L

V

M

M

K

Q

A

Y

A

A

P

P

I

I

G

G

A

V

F

F

G

A

A

L

M

I

A

A

F

Y

T

V

I

M

G

A

K

E

Y

Q

G

G

I

V

G

H

S

V

I

V

A

G

N

E

L

L

A

A

M

K

L

V

I

T

G

A

T

A

F

V

Y

Y

I

V

T

G

S

L

L

T

L

L

F

Q

V

I

L

L

V

L

V

V

L

Y

G

F

A

V

V

L

A

L

R

K

Y

I

N

Y

G

G

F

I

S

D

I

P

L

I

A

S

L

F

L

I

R

K

Y

H

I

A

K

K

E

D

E

A

L

M

L

L

L

T

V

A

L

F

G

V

T

T

S

R

S

S

S
|
S

E

S

A

G

A

T

L

L

P

P

G

V

L

T

M

M

N

R

K

V

M

A

E

K

K

E

A

M

G

G

C

I

K

S

R

E

S

G

V

I

V

Y

G

S

L

F

V

T

I

L

P

P

T

L

G

G

Y

A

S

T

F

I

N

N

L

M

D

D

G

G

T
|
T

N

A

I

L

Y

Y

M

Q

T

G

L

V

A

C

A

T

L

F

F

F

I

I

A

A

Q

N

A

A

T

L

G

G

I

S

Q

H

L

L

S

T

W

V

G

G

D

Q

Q

Q

I

L

L

T

L

I

L

V

L

L

V

T

A

A

M

V

L

L

S

A

S

S

K

I

G

G

A

T

A

A

G

G

I

V

T

P

G

G

A
|
A

G
|
G

F

A

I

I

T

M

L

L

A

A

A

M

T

V

L

L

S

H

V

S

V

V

-

G

-

L

-

P

-

L

-

T

-

D

P

P

S

N

V

V

P

-

V

A

A

A

G

A

M

Y

A

A

L

M

I

I

L

L

G

G

I

I

D

D

R

A

F

I

M

L

S
x
D

E

M

C

G

R
|
R

A
x
T

L

M

T

V

N
|
N

L

V

V

T

G

G

N

D

A

L

V

T

A

G

T

T

I

A

V

I

V

V

A

A

R

K

W

T

E

E

binding (3s)-3-(benzyloxy)-l-aspartic acid: S269 (= S282), T305 (= T318), A349 (= A362), G350 (= G363), D385 (≠ S393), R388 (= R396), T389 (≠ A397), N392 (= N400)

6zl4A The structure of glutamate transporter homologue glttk in complex with the photo switchable compound (cis) (see paper)
32% identity, 88% coverage: 33:422/443 of query aligns to 22:420/424 of 6zl4A

query
sites
6zl4A

G

G

I

L

L

I

L

A

G

G

H

H

F

F

-

G

Y

Y

P

A

-

G

E

A

L

V

G

K

T

T

Q

Y

L

I

K

K

P

P

L

F

G

G

D

D

A

L

F

F

I

V

K

R

L

L

V

L

K

K

M

M

V

L

I

V

A

M

P

P

V

I

I

V

F

L

L

A

T

S

V

L

A

V

T

V

G

G

I

A

A

A

G

S

M

I

S

S

D

P

L

-

K

A

K

R

V

L

G

G

R

R

V

V

A

G

G

V

K

K

A

I

M

V

L

V

Y

Y

F

Y

L

L

T

A

F

T

S

S

T

A

L

M

A

A

L

V

V

F

I

F

G

G

M

L

I

I

V

V

A

G

N

R

V

L

V

F

Q

N

P

V

G

G

A

A

G

-

M

-

N

N

I

V

D

N

P

L

A

G

S

S

L

G

D

T

P

G

K

K

A

A

V

I

A

-

T

-

F

-

A

-

D

-

K

E

A

A

H

Q

E

P

Q

P

S

S

I

L

V

V

G

Q

F

T

L

L

T

L

N

N

I

I

I

V

P

P

T

T

T

N

I

P

V

F

G

A

A

S

F

L

A

A

D

K

G

G

D

E

I

V

L

L

Q

P

V

V

L

I

F

F

S

A

V

I

L

I

F

L

G

G

I

I

A

A

L

I

A

T

M

Y

V

L

G

M

E

N

K

R

G

N

E

E

Q

E

V

R

V

V

T

R

-

K

-

S

-

A

-

E

-

T

-

L

-

R

F

V

L

F

N

D

A

G

L

L

T

A

A

E

P

A

I

M

F

Y

K
x
L

L

I

V

V

G

G

I
x
G

L

V

M

M

K

Q

A

Y

A

A

P

P

I

I

G

G

A

V

F

F

G

A

A

L

M

I

A

A

F

Y

T

V

I

M

G

A

K

E

Y

Q

G

G

I

V

G

R

S

V

I

V

A

G

N

P

L

L

A

A

M

K

L

V

I

V

G

G

T

A

F

V

Y

Y

I

T

T

G

S

L

L

F

L

L

F

Q

V

I

L

V

V

I

V

T

L

Y

G

F

A

I

V

L

A

L

R

K

Y

V

N

F

G

G

F

I

S

D

I

P

L

I

A

K

L

F

L

I

R

R

Y

K

I

A

K

K

E

D

E

A

L

M

L

I

L

T

V

A

L

F

G

V

T

T

S
x
R

S
|
S

E

S

A

G

A

T

L

L

P

P

G

V

L

T

M

M

N
x
R

-

V

K

A

M

E

E

E

K

E

A

M

G

G

C

V

K

D

R

K

S

G

V

I

V

F

G

S

L

F

V

T

I

L

P

P

T

L

G

G

Y

A

S

T

F

I

N

N

L
x
M

D

D

G

G

T
|
T

N

A

I

L

Y

Y

M

Q

T

G

L

V

A

T

A

V

L

L

F

F

I

V

A

A

Q

N

A

A

T

I

G

G

I

H

Q

P

L

L

S

T

W

L

G

G

D

Q

Q

Q

I

L

L

V

L

L

V

T

A

A

M

V

L

L

S

A

S

S

K

I

G

G

A

T

A

A

G

G

I

V

T

P

G
|
G

A
|
A

G

G

F

A

I

I

T

M

L

L

A

A

A

M

T

V

L

L

S

Q

V

S

V

V

-

G

-

L

-

D

-

L

-

T

P

P

S

G

V

S

P

P

V

V

A

A

-

L

G

A

M

Y

A

A

L

M

I

I

L

L

G

G

I

I

D

D

R

A

F

I

M

L

S

D

E

M

C

G

R
|
R

A
x
T

L

M

T

V

N

N

L

V

V

T

G

G

N

D

A

L

V

A

A

G

T

T

I

V

V

I

V

V

A

A

R

K

W

T

E

E

N

K

E

E

L

L

D

D

T

E

G

S

Q

K

binding decyl-beta-d-maltopyranoside: L191 (≠ K200), G195 (≠ I204), R282 (≠ N291)
binding (2~{S},3~{S})-2-azanyl-3-[[4-[2-(4-methoxyphenyl)hydrazinyl]phenyl]methoxy]butanedioic acid: R271 (≠ S280), S272 (= S281), S273 (= S282), M307 (≠ L315), T310 (= T318), G353 (= G361), A354 (= A362), R394 (= R396), T395 (≠ A397)

Sites not aligning to the query:

binding decyl-beta-d-maltopyranoside: 3

6zgbA Glutamate transporter homologue glttk in complex with a photo cage compound (see paper)
32% identity, 88% coverage: 33:422/443 of query aligns to 23:421/425 of 6zgbA

query
sites
6zgbA

G

G

I

L

L

I

L

A

G

G

H

H

F

F

-

G

Y

Y

P

A

-

G

E

A

L

V

G

K

T

T

Q

Y

L

I

K

K

P

P

L

F

G

G

D

D

A

L

F

F

I

V

K

R

L

L

V

L

K

K

M

M

V

L

I

V

A

M

P

P

V

I

I

V

F

L

L

A

T

S

V

L

A

V

T

V

G

G

I

A

A

A

G

S

M

I

S

S

D

P

L

-

K

A

K

R

V

L

G

G

R

R

V

V

A

G

G

V

K

K

A

I

M

V

L

V

Y

Y

F

Y

L

L

T

A

F

T

S

S

T

A

L

M

A

A

L

V

V

F

I

F

G

G

M

L

I

I

V

V

A

G

N

R

V

L

V

F

Q

N

P

V

G

G

A

A

G

-

M

-

N

N

I

V

D

N

P

L

A

G

S

S

L

G

D

T

P

G

K

K

A

A

V

I

A

-

T

-

F

-

A

-

D

-

K

E

A

A

H

Q

E

P

Q

P

S

S

I

L

V

V

G

Q

F

T

L

L

T

L

N

N

I

I

I

V

P

P

T

T

T

N

I

P

V

F

G

A

A

S

F

L

A

A

D

K

G

G

D

E

I

V

L

L

Q

P

V

V

L

I

F

F

S

A

V

I

L

I

F

L

G

G

I

I

A

A

L

I

A

T

M

Y

V

L

G

M

E

N

K

R

G

N

E

E

Q

E

V

R

V

V

T

R

-

K

-

S

-

A

-

E

-

T

-

L

-

R

F

V

L

F

N

D

A

G

L

L

T

A

A

E

P

A

I

M

F

Y

K

L

L

I

V

V

G

G

I

G

L

V

M

M

K

Q

A

Y

A

A

P

P

I

I

G

G

A

V

F

F

G

A

A

L

M

I

A

A

F

Y

T

V

I

M

G

A

K

E

Y

Q

G

G

I

V

G

R

S

V

I

V

A

G

N

P

L

L

A

A

M

K

L

V

I

V

G

G

T

A

F

V

Y

Y

I

T

T

G

S

L

L

F

L

L

F

Q

V

I

L

V

V

I

V

T

L

Y

G

F

A

I

V

L

A

L

R

K

Y

V

N

F

G

G

F

I

S

D

I

P

L

I

A

K

L

F

L

I

R

R

Y

K

I

A

K

K

E

D

E

A

L

M

L

I

L

T

V

A

L

F

G

V

T

T

S
x
R

S
|
S

E

S

A

G

A

T

L

L

P

P

G

V

L

T

M

M

N

R

-

V

K

A

M

E

E

E

K

E

A

M

G

G

C

V

K

D

R

K

S

G

V

I

V

F

G

S

L

F

V

T

I

L

P

P

T

L

G

G

Y

A

S

T

F

I

N

N

L
x
M

D

D

G

G

T

T

N

A

I

L

Y

Y

M

Q

T

G

L

V

A

T

A

V

L

L

F

F

I

V

A

A

Q

N

A

A

T

I

G

G

I

H

Q

P

L

L

S

T

W

L

G

G

D

Q

Q

Q

I

L

L

V

L

L

V

T

A

A

M

V

L

L

S

A

S

S

K

I

G

G

A

T

A

A

G

G

I

V

T

P

G

G

A

A

G

G

F

A

I

I

T

M

L

L

A

A

A

M

T

V

L

L

S

Q

V

S

V

V

-

G

-

L

-

D

-

L

-

T

P

P

S

G

V

S

P

P

V

V

A

A

-

L

G

A

M

Y

A

A

L

M

I

I

L

L

G

G

I

I

D

D

R

A

F

I

M

L

S
x
D

E

M

C

G

R
|
R

A
x
T

L

M

T

V

N

N

L

V

V

T

G

G

N

D

A

L

V

A

A

G

T

T

I

V

V

I

V

V

A

A

R

K

W

T

E

E

N

K

E

E

L

L

D

D

T

E

G

S

Q

K

binding (2~{S},3~{S})-2-azanyl-3-[(2-nitrophenyl)methoxy]butanedioic acid: R272 (≠ S280), S273 (= S281), S274 (= S282), M308 (≠ L315), D392 (≠ S393), R395 (= R396), T396 (≠ A397)

5e9sA Crystal structure of substrate-bound glutamate transporter homologue glttk (see paper)
32% identity, 88% coverage: 33:422/443 of query aligns to 25:423/427 of 5e9sA

query
sites
5e9sA

G

G

I

L

L

I

L

A

G

G

H

H

F

F

-

G

Y

Y

P

A

-

G

E

A

L

V

G

K

T

T

Q

Y

L

I

K

K

P

P

L

F

G

G

D

D

A

L

F

F

I

V

K

R

L

L

V

L

K

K

M

M

V

L

I

V

A

M

P

P

V

I

I

V

F

L

L

A

T

S

V

L

A

V

T

V

G

G

I

A

A

A

G

S

M

I

S

S

D

P

L

-

K

A

K

R

V

L

G

G

R

R

V

V

A

G

G

V

K

K

A

I

M

V

L

V

Y

Y

F
x
Y

L

L

T

A

F
x
T

S
|
S

T

A

L

M

A

A

L

V

V

F

I

F

G

G

M

L

I

I

V

V

A

G

N

R

V

L

V

F

Q

N

P

V

G

G

A

A

G

N

M

V

N

N

I

L

D

G

P

S

A

G

S

T

L

-

D

-

P

G

K

K

A

A

V

I

A

-

T

-

F

-

A

-

D

-

K

E

A

A

H

Q

E

P

Q

P

S

S

I

L

V

V

G

Q

F

T

L

L

T

L

N

N

I

I

I

V

P

P

T

T

T

N

I

P

V

F

G

A

A

S

F

L

A

A

D

K

G

G

D

E

I

V

L

L

Q

P

V

V

L

I

F

F

S

A

V

I

L

I

F

L

G

G

I

I

A

A

L

I

A

T

M

Y

V

L

G

M

E

N

K

R

G

N

E

E

Q

E

V

R

V

V

T

R

-

K

-

S

-

A

-

E

-

T

-

L

-

R

F

V

L

F

N

D

A

G

L

L

T

A

A

E

P

A

I

M

F

Y

K
x
L

L

I

V

V

G

G

I
x
G

L

V

M

M

K

Q

A
x
Y

A

A

P

P

I

I

G

G

A

V

F

F

G

A

A

L

M

I

A

A

F

Y

T

V

I

M

G

A

K

E

Y

Q

G

G

I

V

G

R

S

V

I

V

A

G

N

P

L

L

A

A

M

K

L

V

I

V

G

G

T

A

F

V

Y

Y

I

T

T

G

S

L

L

F

L

L

F

Q

V

I

L

V

V

I

V

T

L

Y

G

F

A

I

V

L

A

L

R

K

Y

V

N

F

G

G

F

I

S

D

I

P

L

I

A

K

L

F

L

I

R

R

Y

K

I

A

K

K

E

D

E

A

L

M

L

I

L

T

V

A

L

F

G

V

T

T

S
x
R

S
|
S

E

S

A

G

A

T

L

L

P

P

G

V

L

T

M

M

N

R

-

V

K

A

M

E

E

E

K

E

A

M

G

G

C

V

K

D

R

K

S

G

V

I

V

F

G

S

L

F

V

T

I

L

P

P

T

L

G
|
G

Y
x
A

S
x
T

F

I

N
|
N

L
x
M

D
|
D

G

G

T
|
T

N

A

I

L

Y

Y

M

Q

T

G

L

V

A

T

A

V

L

L

F

F

I

V

A

A

Q

N

A

A

T

I

G

G

I

H

Q

P

L

L

S

T

W

L

G

G

D

Q

Q

Q

I

L

L

V

L

L

V

T

A

A

M

V

L

L

S

A

S
|
S

K
x
I

G
|
G

A
x
T

A

A

G
|
G

I
x
V

T

P

G

G

A
|
A

G
|
G

F

A

I

I

T

M

L

L

A

A

A

M

T

V

L

L

S

Q

V

S

V

V

-

G

-

L

-

D

-

L

-

T

P

P

S

G

V

S

P

P

V

V

A

A

-

L

G

A

M

Y

A

A

L

M

I

I

L

L

G

G

I

I

D

D

R

A

F

I

M

L

S
x
D

E

M

C

G

R
|
R

A
x
T

L

M

T

V

N
|
N

L
x
V

V

T

G

G

N
x
D

A

L

V

A

A

G

T

T

I

V

V

I

V

V

A

A

R

K

W

T

E

E

N

K

E

E

L

L

D

D

T

E

G

S

Q

K

binding aspartic acid: R274 (≠ S280), S275 (= S281), S276 (= S282), T313 (= T318), G353 (= G358), V354 (≠ I359), A357 (= A362), G358 (= G363), D394 (≠ S393), R397 (= R396), T398 (≠ A397)
binding decyl-beta-d-maltopyranoside: L194 (≠ K200), G198 (≠ I204), Y202 (≠ A208)
binding sodium ion: Y87 (≠ F94), T90 (≠ F97), S91 (= S98), S276 (= S282), G305 (= G310), A306 (≠ Y311), T307 (≠ S312), N309 (= N314), N309 (= N314), M310 (≠ L315), D311 (= D316), S348 (= S353), I349 (≠ K354), G350 (= G355), T351 (≠ A356), N401 (= N400), V402 (≠ L401), D405 (≠ N404)

6xwnB Structure of glutamate transporter homologue glttk in the presence of tboa inhibitor (see paper)
32% identity, 88% coverage: 33:422/443 of query aligns to 25:423/426 of 6xwnB

query
sites
6xwnB

G

G

I

L

L

I

L

A

G

G

H

H

F

F

-

G

Y

Y

P

A

-

G

E

A

L

V

G

K

T

T

Q

Y

L

I

K

K

P

P

L

F

G

G

D

D

A

L

F

F

I

V

K

R

L

L

V

L

K

K

M

M

V

L

I

V

A

M

P

P

V

I

I

V

F

L

L

A

T

S

V

L

A

V

T

V

G

G

I

A

A

A

G

S

M

I

S

S

D

P

L

-

K

A

K

R

V

L

G

G

R

R

V

V

A

G

G

V

K

K

A

I

M

V

L

V

Y

Y

F

Y

L

L

T

A

F

T

S

S

T

A

L

M

A

A

L

V

V

F

I

F

G

G

M

L

I

I

V

V

A

G

N

R

V

L

V

F

Q

N

P

V

G

G

A

A

G

N

M

V

N

N

I

L

D

G

P

S

A

G

S

T

L

-

D

-

P

G

K

K

A

A

V

I

A

-

T

-

F

-

A

-

D

-

K

E

A

A

H

Q

E

P

Q

P

S

S

I

L

V

V

G

Q

F

T

L

L

T

L

N

N

I

I

I

V

P

P

T

T

T

N

I

P

V

F

G

A

A

S

F

L

A

A

D

K

G

G

D

E

I

V

L

L

Q

P

V

V

L

I

F

F

S

A

V

I

L

I

F

L

G

G

I

I

A

A

L

I

A

T

M

Y

V

L

G

M

E

N

K

R

G

N

E

E

Q

E

V

R

V

V

T

R

-

K

-

S

-

A

-

E

-

T

-

L

-

R

F

V

L

F

N

D

A

G

L

L

T

A

A

E

P

A

I

M

F

Y

K

L

L

I

V

V

G

G

I

G

L

V

M

M

K

Q

A

Y

A

A

P

P

I

I

G

G

A

V

F

F

G

A

A

L

M

I

A

A

F

Y

T

V

I

M

G

A

K

E

Y

Q

G

G

I

V

G

R

S

V

I

V

A

G

N

P

L

L

A

A

M

K

L

V

I

V

G

G

T

A

F

V

Y

Y

I

T

T

G

S

L

L

F

L

L

F

Q

V

I

L

V

V

I

V

T

L

Y

G

F

A

I

V

L

A

L

R

K

Y

V

N

F

G

G

F

I

S

D

I

P

L

I

A

K

L

F

L

I

R

R

Y

K

I

A

K

K

E

D

E

A

L

M

L

I

L

T

V

A

L

F

G

V

T

T

S

R

S
|
S

E

S

A

G

A

T

L

L

P

P

G

V

L

T

M

M

N

R

-

V

K

A

M

E

E

E

K

E

A

M

G

G

C

V

K

D

R

K

S

G

V

I

V

F

G

S

L

F

V

T

I

L

P

P

T

L

G

G

Y

A

S

T

F

I

N

N

L
x
M

D

D

G

G

T
|
T

N

A

I

L

Y

Y

M

Q

T

G

L

V

A

T

A

V

L

L

F

F

I

V

A

A

Q

N

A

A

T

I

G

G

I

H

Q

P

L

L

S

T

W

L

G

G

D

Q

Q

Q

I

L

L

V

L

L

V

T

A

A

M

V

L

L

S

A

S

S

K

I

G

G

A

T

A

A

G

G

I

V

T

P

G

G

A

A

G

G

F

A

I

I

T

M

L

L

A

A

A

M

T

V

L

L

S

Q

V

S

V

V

-

G

-

L

-

D

-

L

-

T

P

P

S

G

V

S

P

P

V

V

A

A

-

L

G

A

M

Y

A

A

L

M

I

I

L

L

G

G

I

I

D

D

R

A

F

I

M

L

S
x
D

E

M

C

G

R
|
R

A

T

L

M

T

V

N

N

L

V

V

T

G

G

N

D

A

L

V

A

A

G

T

T

I

V

V

I

V

V

A

A

R

K

W

T

E

E

N

K

E

E

L

L

D

D

T

E

G

S

Q

K

binding (3s)-3-(benzyloxy)-l-aspartic acid: S275 (= S281), S276 (= S282), M310 (≠ L315), T313 (= T318), D394 (≠ S393), R397 (= R396)

6x15A Inward-facing state of the glutamate transporter homologue gltph in complex with l-aspartate and sodium ions (see paper)
32% identity, 89% coverage: 26:418/443 of query aligns to 21:419/419 of 6x15A

query
sites
6x15A

V

I

L

L

A

G

A

A

I

I

A

V

A

-

G

G

I

L

L

I

L

L

G

G

H

H

F

Y

-

G

Y

Y

P

A

E

H

-

A

L

V

G

H

T

T

Q

Y

L

V

K

K

P

P

L
x
F

G

G

D

D

A

L

F

F

I

V

K

R

L

L

V

L

K

C

M

M

V

L

I

V

A

M

P

P

V

I

I

V

F

F

L

A

T

S

V

L

A

V

T

V

G

G

I

A

A

A

G

S

M

I

S

S

D
x
P

L

-

K

A

K

R

V

L

G

G

R

R

V

V

A

G

G

V

K

K

A

I

M

V

L

V

Y

Y

F
x
Y

L

L

T
x
L

F
x
T

S
|
S

T

A

L
x
F

A

A

L

V

V

T

I

L

G

G

M

I

I

I

V

M

A

A

N

R

V

L

V

F

Q

N

P

P

G

G

A

A

G

G

M

I

N

H

I

L

D

-

P

-

A

-

S

-

L

-

D

-

P

-

K

-

A

A

V

V

A

G

T

G

F

Q

A

Q

D

F

K

Q

A

P

H

H

E

Q

-

A

Q

P

S

P

I
x
L

V

V

G

H

F
x
I

L

L

T

L

N

D

I

I

I

V

P

P

T

T

T

N

I

P

V

F

G

G

A

A

F

L

A

A

D

N

G

G

D

Q

I

V

L

L

Q

P

V

T

L

I

F

F

S

A

V
x
I

L

I

F

L

G

G

I

I

A

A

L

I

A

T

M
x
Y

-

L

-

M

-

N

-

S

-

E

-

N

-

E

-

K

V

V

G

R

E

K

K

S

G

A

E

E

Q

T

V

L

T

D

F

A

L

I

N

N

A

G

L

L

T

A

A

E

P

A

I

M

F

Y

K
|
K

L

I

V

V

G

N

I
x
G

L

V

M

M

K

Q

A

Y

A

A

P

P

I
|
I

G

G

A

V

F
|
F

G

A

A

L

M

I

A

A

F

Y

T

V

I

M

G

A

K

E

Y

Q

G

G

I

V

G

H

S

V

I

V

A

G

N

E

L

L

A

A

M

K

L

V

I

T

G

A

T

A

F

V

Y

Y

I

V

T

G

S

L

L

T

L

L

F

Q

V

I

L

L

V

L

V

V

L

Y

G

F

A

V

V
x
L

A

L

R

K

Y

I

N

Y

G

G

F

I

S

D

I

P

L

I

A

S

L

F

L
x
I

R

K

Y

H

I

A

K

K

E

D

E

A

L
x
M

L

L

L

T

V

A

L

F

G

V

T

T

S

R

S
|
S

E

S

A

G

A

T

L

L

P

P

G

V

L

T

M

M

N

R

K

V

M

A

E

K

K

E

A

M

G

G

C

I

K

S

R

E

S

G

V

I

V

Y

G

S

L

F

V

T

I

L

P

P

T

L

G
|
G

Y

A

S
x
T

F

I

N
|
N

L
x
M

D
|
D

G

G

T
|
T

N

A

I

L

Y

Y

M

Q

T

G

L

V

A

A

A

T

L

F

F

F

I

I

A

A

Q

N

A

A

T

L

G

G

I

S

Q

H

L

L

S
x
T

W
x
V

G
|
G

D

Q

Q

Q

I

L

L
x
T

L

I

L

V

L
|
L

V

T

A

A

M

V

L

L

S

A

S
|
S

K
x
I

G

G

A
x
T

A

A

G
|
G

I

V

T

P

G

G

A
|
A

G
|
G

F

A

I

I

T

M

L

L

A

C

A

M

T

V

L

L

S

H

V

S

V

V

-

G

-

L

-

P

-

L

-

T

-

D

P

P

S

N

V

V

P

-

V

A

A

A

G

A

M

Y

A

A

L

M

I

I

L

L

G

G

I

I

D

D

R

A

F

I

M

L

S
x
D

E

M

C

G

R
|
R

A
x
T

L
x
M

T

V

N
|
N

L
x
V

V

T

G

G

N
x
D

A

L

V

T

A

G

T

T

I

A

V

I

V

V

A

A

R

K

W

T

E

E

N

G

E

T

L

L

binding [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate: F46 (≠ L50), F46 (≠ L50), P75 (≠ D79), L91 (≠ T96), F95 (≠ L100), L130 (≠ I142), I133 (≠ F145), I159 (≠ V171), Y167 (≠ M179), K196 (= K200), G200 (≠ I204), I207 (= I211), F210 (= F214), L250 (≠ V254), I262 (≠ L266), M269 (≠ L273), T334 (≠ S338), V335 (≠ W339), G336 (= G340), T340 (≠ L344), L343 (= L347), M399 (≠ L398)
binding aspartic acid: S277 (= S281), S278 (= S282), T314 (= T318), G354 (= G358), A358 (= A362), G359 (= G363), D394 (≠ S393), R397 (= R396), T398 (≠ A397)
binding sodium ion: Y89 (≠ F94), T92 (≠ F97), S93 (= S98), G306 (= G310), T308 (≠ S312), N310 (= N314), N310 (= N314), M311 (≠ L315), D312 (= D316), S349 (= S353), I350 (≠ K354), T352 (≠ A356), N401 (= N400), V402 (≠ L401), D405 (≠ N404)

Sites not aligning to the query:

binding [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate: 4, 7

6x14A Inward-facing state of the glutamate transporter homologue gltph in complex with tfb-tboa (see paper)
32% identity, 88% coverage: 26:415/443 of query aligns to 18:413/413 of 6x14A

query
sites
6x14A

V

I

L

L

A

G

A

A

I

I

A

V

A

-

G

G

I

L

L

I

L

L

G

G

H

H

F

Y

-

G

Y

Y

P

A

E

H

-

A

L

V

G

H

T

T

Q

Y

L

V

K

K

P

P

L

F

G

G

D

D

A

L

F

F

I

V

K

R

L

L

V

L

K

C

M

M

V

L

I

V

A

M

P

P

V

I

I

V

F

F

L

A

T

S

V

L

A

V

T

V

G
|
G

I

A

A

A

G

S

M

I

S

S

D

P

L

-

K

A

K

R

V

L

G

G

R

R

V

V

A

G

G

V

K

K

A

I

M
x
V

L

V

Y

Y

F

Y

L

L

T

L

F

T

S

S

T

A

L

F

A

A

L

V

V

T

I

L

G

G

M

I

I

I

V

M

A

A

N

R

V

L

V

F

Q

N

P

P

G

G

A

A

G

G

M

I

N

H

I

L

D

-

P

-

A

-

S

-

L

-

D

-

P

-

K

-

A

A

V

V

A

G

T

G

F

Q

A

Q

D

F

K

Q

A

P

H

H

E

Q

-

A

Q

P

S

P

I

L

V

V

G

H

F

I

L

L

T

L

N

D

I

I

I

V

P

P

T

T

T

N

I

P

V

F

G

G

A

A

F

L

A

A

D

N

G

G

D

Q

I

V

L

L

Q

P

V

T

L

I

F

F

S

A

V

I

L
x
I

F

L

G

G

I

I

A

A

L

I

A

T

M
x
Y

-

L

-

M

-

N

-

S

-

E

-

N

-

E

-

K

V

V

G

R

E

K

K

S

G

A

E

E

Q

T

V

L

T

D

F

A

L

I

N

N

A

G

L

L

T

A

A

E

P

A

I

M

F

Y

K
|
K

L

I

V

V

G

N

I

G

L

V

M
|
M

K

Q

A

Y

A

A

P

P

I

I

G

G

A

V

F

F

G

A

A

L

M

I

A

A

F

Y

T

V

I

M

G

A

K

E

Y

Q

G

G

I

V

G

H

S

V

I

V

A

G

N

E

L

L

A

A

M

K

L

V

I

T

G

A

T

A

F

V

Y

Y

I

V

T

G

S

L

L

T

L

L

F

Q

V

I

L

L

V

L

V

V

L

Y

G

F

A

V

V

L

A

L

R

K

Y

I

N

Y

G

G

F

I

S

D

I

P

L

I

A

S

L

F

L

I

R

K

Y

H

I

A

K

K

E

D

E

A

L

M

L

L

L

T

V

A

L

F

G

V

T

T

S

R

S

S

S
|
S

E

S

A

G

A

T

L

L

P

P

G

V

L

T

M

M

N

R

K

V

M

A

E

K

K

E

A

M

G

G

C

I

K

S

R

E

S

G

V

I

V

Y

G

S

L

F

V

T

I

L

P

P

T

L

G

G

Y

A

S
x
T

F
x
I

N

N

L

M

D

D

G

G

T
|
T

N

A

I

L

Y

Y

M

Q

T

G

L

V

A

A

A

T

L

F

F

F

I

I

A

A

Q

N

A

A

T

L

G

G

I

S

Q

H

L

L

S

T

W

V

G

G

D

Q

Q

Q

I

L

L

T

L

I

L

V

L

L

V

T

A

A

M

V

L

L

S

A

S

S

K
x
I

G

G

A

T

A

A

G

G

I

V

T

P

G

G

A

A

G
|
G

F

A

I

I

T

M

L

L

A

C

A

M

T

V

L

L

S

H

V

S

V

V

-

G

-

L

-

P

-

L

-

T

-

D

P

P

S

N

V

V

P

-

V

A

A

A

G

A

M

Y

A

A

L

M

I

I

L
|
L

G

G

I

I

D

D

R

A

F

I

M

L

S
x
D

E

M

C

G

R
|
R

A

T

L

M

T

V

N

N

L

V

V

T

G

G

N

D

A

L

V

T

A

G

T

T

I

A

V

I

V

V

A

A

R

K

W

T

E

E

binding [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate: G66 (= G73), V83 (≠ M91), I157 (≠ L172), Y164 (≠ M179), K193 (= K200), T305 (≠ S312), I306 (≠ F313), I347 (≠ K354)
binding (2~{S},3~{S})-2-azanyl-3-[[3-[[4-(trifluoromethyl)phenyl]carbonylamino]phenyl]methoxy]butanedioic acid: M199 (= M206), S275 (= S282), T311 (= T318), G356 (= G363), L384 (= L386), D391 (≠ S393), R394 (= R396)

Sites not aligning to the query:

6r7rA Crystal structure of the glutamate transporter homologue glttk in complex with d-aspartate (see paper)
31% identity, 88% coverage: 33:422/443 of query aligns to 18:412/416 of 6r7rA

query
sites
6r7rA

G

G

I

L

L

I

L

A

G

G

H
|
H

F

F

-

G

Y

Y

P

A

-

G

E

A

L

V

G

K

T

T

Q

Y

L

I

K

K

P

P

L

F

G

G

D

D

A

L

F

F

I

V

K

R

L

L

V

L

K

K

M

M

V

L

I

V

A

M

P

P

V

I

I

V

F

L

L

A

T

S

V

L

A

V

T

V

G

G

I

A

A

A

G

S

M

I

S

S

D

P

L

-

K

A

K

R

V

L

G

G

R

R

V

V

A

G

G

V

K

K

A

I

M

V

L

V

Y

Y

F

Y

L

L

T

A

F

T

S

S

T

A

L

M

A

A

L

V

V

F

I

F

G

G

M

L

I

I

V

V

A

G

N

R

V

L

V

F

Q

N

P

V

G

G

A

A

G

N

M

V

N

N

I

L

D

G

P

S

A

G

S

T

L

-

D

-

P

-

K

-

A

-

V

-

A

-

T

-

F

-

A

-

D

-

K

G

A

A

H

Q

E

P

Q

P

S

S

I

L

V

V

G

Q

F

T

L

L

T

L

N

N

I

I

I

V

P

P

T

T

T

N

I

P

V

F

G

A

A

S

F

L

A

A

D

K

G

G

D

E

I

V

L

L

Q

P

V

V

L

I

F

F

S

A

V

I

L

I

F

L

G

G

I

I

A

A

L

I

A

T

M

Y

V

L

G

M

E

N

K

R

G

N

E

E

Q

E

V

R

V

V

T

R

-

K

-

S

-

A

-

E

-

T

-

L

-

R

F

V

L

F

N

D

A

G

L

L

T

A

A

E

P

A

I

M

F

Y

K

L

L

I

V

V

G

G

I

G

L

V

M

M

K

Q

A

Y

A

A

P

P

I

I

G

G

A

V

F

F

G

A

A

L

M

I

A

A

F

Y

T

V

I

M

G

A

K

E

Y

Q

G

G

I

V

G

R

S

V

I
x
V

A

G

N

P

L

L

A
|
A

M

K

L

V

I

V

G

G

T

A

F

V

Y

Y

I

T

T

G

S

L

L

F

L

L

F

Q

V

I

L

V

V

I

V

T

L

Y

G

F

A

I

V

L

A

L

R

K

Y

V

N

F

G

G

F

I

S

D

I

P

L

I

A

K

L

F

L

I

R

R

Y

K

I

A

K

K

E

D

E

A

L

M

L

I

L

T

V

A

L

F

G

V

T

T

S
x
R

S

S

S
|
S

E

S

A

G

A

T

L

L

P

P

G

V

L

T

M

M

N

R

-

V

K

A

M

E

E

E

K

E

A

M

G

G

C

V

K

D

R

K

S

G

V

I

V

F

G

S

L

F

V

T

I

L

P

P

T

L

G

G

Y

A

S

T

F

I

N

N

L
x
M

D

D

G

G

T
|
T

N

A

I

L

Y

Y

M

Q

T

G

L

V

A

T

A

V

L

L

F

F

I

V

A

A

Q

N

A

A

T

I

G

G

I

H

Q

P

L

L

S

T

W

L

G

G

D

Q

Q

Q

I

L

L

V

L

L

V

T

A

A

M

V

L

L

S

A

S

S

K

I

G

G

A
x
T

A

A

G
|
G

I
x
V

T

P

G

G

A

A

G
|
G

F

A

I

I

T

M

L

L

A

A

A

M

T

V

L

L

S

Q

V

S

V

V

-

G

-

L

-

D

-

L

-

T

P

P

S

G

V

S

P

P

V

V

A

A

-

L

G

A

M

Y

A

A

L

M

I

I

L

L

G

G

I

I

D

D

R

A

F

I

M

L

S
x
D

E

M

C

G

R
|
R

A
x
T

L

M

T

V

N
|
N

L

V

V

T

G

G

N

D

A

L

V

A

A

G

T

T

I

V

V

I

V

V

A

A

R

K

W

T

E

E

N

K

E

E

L

L

D

D

T

E

G

S

Q

K

binding d-aspartic acid: R263 (≠ S280), S265 (= S282), M299 (≠ L315), T302 (= T318), T340 (≠ A356), G342 (= G358), V343 (≠ I359), G347 (= G363), D383 (≠ S393), R386 (= R396), T387 (≠ A397), N390 (= N400)
binding decyl-beta-d-maltopyranoside: H23 (= H38), V212 (≠ I229), A216 (= A233)

6bauA Crystal structure of gltph r397c in complex with l-cysteine (see paper)
31% identity, 86% coverage: 33:415/443 of query aligns to 19:408/408 of 6bauA

query
sites
6bauA

G

G

I

L

L

I

L

L

G

G

H

H

F

Y

-

G

Y

Y

P

A

E

D

-

A

L

V

G

K

T

T

Q

Y

L

V

K

K

P

P

L

F

G

G

D

D

A

L

F

F

I

V

K

R

L

L

V

L

K

K

M

M

V

L

I

V

A

M

P

P

V

I

I

V

F

F

L

A

T

S

V

L

A

V

T

V

G

G

I

A

A

A

G

S

M

I

S

S

D

P

L

-

K

A

K

R

V

L

G

G

R

R

V

V

A

G

G

V

K

K

A

I

M

V

L

V

Y

Y

F

Y

L

L

T

L

F

T

S

S

T

A

L

F

A

A

L

V

V

T

I

L

G

G

M

I

I

I

V

M

A

A

N

R

V

L

V

F

Q

N

P

P

G

G

A

A

G

G

M

I

N

H

-

L

-

A

I

V

D

G

P

G

A

Q

S

Q

L

F

D

Q

P

P

K

K

A

-

V

-

A

-

T

-

F

-

A

-

D

-

K

-

A

-

H

Q

E

A

Q

P

S

P

I

L

V

V

G

K

F

I

L

L

T

L

N

D

I

I

I

V

P

P

T

T

T

N

I

P

V

F

G

G

A

A

F

L

A

A

D

N

G

G

D

Q

I

V

L

L

Q

P

V

T

L

I

F

F

S

A

V

I

L

I

F

L

G

G

I

I

A

A

L

I

A

T

M

Y

-

L

-

M

-

N

-

S

-

E

-

N

-

E

-

K

V

V

G

R

E

K

K

S

G

A

E

E

Q

T

V

L

T

D

F

A

L

I

N

N

A

G

L

L

T

A

A

E

P

A

I

M

F

Y

K

K

L

I

V

V

G

N

I

G

L

V

M

M

K

Q

A

Y

A

A

P

P

I

I

G

G

A

V

F

F

G

A

A

L

M

I

A

A

F

Y

T

V

I

M

G

A

K

E

Y

Q

G

G

I

V

G

K

S

V

I

V

A

G

N

E

L

L

A

A

M

K

L

V

I

T

G

A

T

A

F

V

Y

Y

I

V

T

G

S

L

L

T

L

L

F

Q

V

I

L

L

V

L

V

V

L

Y

G

F

A

V

V

L

A

L

R

K

Y

I

N

Y

G

G

F

I

S

D

I

P

L

I

A

S

L

F

L

I

R

K

Y

K

I

A

K

K

E

D

E

A

L

M

L

L

L

T

V

A

L

F

G

V

T

T

S

R

S

S

S
|
S

E

S

A

G

A

T

L

L

P

P

G

V

L

T

M

M

N

R

K

V

M

A

E

K

K

E

A

M

G

G

C

I

K

S

R

E

S

G

V

I

V

Y

G

S

L

F

V

T

I

L

P

P

T

L

G

G

Y

A

S

T

F

I

N

N

L
x
M

D

D

G

G

T
|
T

N

A

I

L

Y

Y

M

Q

T

G

L

V

A

C

A

T

L

F

F

F

I

I

A

A

Q

N

A

A

T

L

G

G

I

S

Q

H

L

L

S

T

W

V

G

G

D

Q

Q

Q

I

L

L

T

L

I

L

V

L

L

V

T

A

A

M

V

L

L

S

A

S

S

K

I

G

G

A

T

A
|
A

G
|
G

I
x
V

T

P

G

G

A

A

G
|
G

F

A

I

I

T

M

L

L

A

A

A

M

T

V

L

L

S

E

V

S

V

V

-

G

-

L

-

P

-

L

-

T

-

D

P

P

S

N

V

V

P

-

V

A

A

A

G

A

M

Y

A

A

L

M

I

I

L

L

G

G

I

I

D

D

R

A

F

I

M

L

S
x
D

E

M

C

G

R
x
C

A
x
T

L

M

T

V

N
|
N

L

V

V

T

G

G

N

D

A

L

V

T

A

G

T

T

I

A

V

I

V

V

A

A

R

K

W

T

E

E

binding cysteine: S270 (= S282), M303 (≠ L315), T306 (= T318), A345 (= A357), G346 (= G358), V347 (≠ I359), G351 (= G363), D386 (≠ S393), C389 (≠ R396), T390 (≠ A397), N393 (= N400)

6bavA Crystal structure of gltph r397c in complex with s-benzyl-l-cysteine (see paper)
32% identity, 88% coverage: 26:415/443 of query aligns to 13:408/409 of 6bavA

query
sites
6bavA

V

I

L

L

A

G

A

A

I

I

A

V

A

-

G

G

I

L

L

I

L

L

G

G

H

H

F

Y

-

G

Y

Y

P

A

E

D

-

A

L

V

G

K

T

T

Q

Y

L

V

K

K

P

P

L

F

G

G

D

D

A

L

F

F

I

V

K

R

L

L

V

L

K

K

M

M

V

L

I

V

A

M

P

P

V

I

I

V

F

F

L

A

T

S

V

L

A

V

T

V

G

G

I

A

A

A

G

S

M

I

S

S

D

P

L

-

K

A

K

R

V

L

G

G

R

R

V

V

A

G

G

V

K

K

A

I

M

V

L

V

Y

Y

F

Y

L

L

T

L

F

T

S

S

T

A

L

F

A

A

L

V

V

T

I

L

G

G

M

I

I

I

V

M

A

A

N

R

V

L

V

F

Q

N

P

P

G

G

A

A

G

G

M

I

N

H

-

L

-

A

I

V

D

G

P

G

A

Q

S

Q

L

F

D

Q

P

P

K

K

A

-

V

-

A

-

T

-

F

-

A

-

D

-

K

-

A

-

H

Q

E

A

Q

P

S

P

I

L

V

V

G

K

F

I

L

L

T

L

N

D

I

I

I

V

P

P

T

T

T

N

I

P

V

F

G

G

A

A

F

L

A

A

D

N

G

G

D

Q

I

V

L

L

Q

P

V

T

L

I

F

F

S

A

V

I

L

I

F

L

G

G

I

I

A

A

L

I

A

T

M

Y

-

L

-

M

-

N

-

S

-

E

-

N

-

E

-

K

V

V

G

R

E

K

K

S

G

A

E

E

Q

T

V

L

T

D

F

A

L

I

N

N

A

G

L

L

T

A

A

E

P

A

I

M

F

Y

K

K

L

I

V

V

G

N

I

G

L

V

M

M

K

Q

A

Y

A

A

P

P

I

I

G

G

A

V

F

F

G

A

A

L

M

I

A

A

F

Y

T

V

I

M

G

A

K

E

Y

Q

G

G

I

V

G

K

S

V

I

V

A

G

N

E

L

L

A

A

M

K

L

V

I

T

G

A

T

A

F

V

Y

Y

I

V

T

G

S

L

L

T

L

L

F

Q

V

I

L

L

V

L

V

V

L

Y

G

F

A

V

V

L

A

L

R

K

Y

I

N

Y

G

G

F

I

S

D

I

P

L

I

A

S

L

F

L

I

R

K

Y

K

I

A

K

K

E

D

E

A

L

M

L

L

L

T

V

A

L

F

G

V

T

T

S
x
R

S

S

S
|
S

E

S

A

G

A

T

L

L

P

P

G

V

L

T

M

M

N

R

K

V

M

A

E

K

K

E

A

M

G

G

C

I

K

S

R

E

S

G

V

I

V

Y

G

S

L

F

V

T

I

L

P

P

T

L

G

G

Y

A

S

T

F

I

N

N

L

M

D

D

G

G

T
|
T

N

A

I

L

Y
|
Y

M

Q

T

G

L

V

A

C

A

T

L

F

F

F

I

I

A

A

Q

N

A

A

T

L

G

G

I

S

Q

H

L

L

S

T

W

V

G

G

D

Q

Q

Q

I

L

L

T

L

I

L

V

L

L

V

T

A

A

M

V

L

L

S

A

S

S

K

I

G

G

A

T

A

A

G

G

I

V

T

P

G

G

A

A

G

G

F

A

I

I

T

M

L

L

A

A

A

M

T

V

L

L

S

E

V

S

V

V

-

G

-

L

-

P

-

L

-

T

-

D

P

P

S

N

V

V

P

-

V

A

A

A

G

A

M

Y

A

A

L

M

I

I

L

L

G

G

I

I

D
|
D

R

A

F

I

M

L

S
x
D

E

M

C

G

R
x
C

A
x
T

L

M

T

V

N

N

L

V

V

T

G

G

N

D

A

L

V

T

A

G

T

T

I

A

V

I

V

V

A

A

R

K

W

T

E

E

binding benzylcysteine: R268 (≠ S280), S270 (= S282), T306 (= T318), Y309 (= Y321), D382 (= D389), D386 (≠ S393), C389 (≠ R396), T390 (≠ A397)

6bmiA Crystal structure of gltph r397c in complex with l-serine (see paper)
30% identity, 86% coverage: 33:415/443 of query aligns to 19:396/396 of 6bmiA

query
sites
6bmiA

G

G

I

L

L

I

L

L

G

G

H

H

F

Y

-

G

Y

Y

P

A

E

D

-

A

L

V

G

K

T

T

Q

Y

L

V

K

K

P

P

L

F

G

G

D

D

A

L

F

F

I

V

K

R

L

L

V

L

K

K

M

M

V

L

I

V

A

M

P

P

V

I

I

V

F

F

L

A

T

S

V

L

A

V

T

V

G

G

I

A

A

A

G

S

M

I

S

S

D

P

L

-

K

A

K

R

V

L

G

G

R

R

V

V

A

G

G

V

K

K

A

I

M

V

L

V

Y

Y

F

Y

L

L

T

L

F

T

S

S

T

A

L

F

A

A

L

V

V

T

I

L

G

G

M

I

I

I

V

M

A

A

N

R

V

L

V

F

Q

N

P

P

G

G

A

A

G

G

M

I

N

H

-

L

-

A

I

V

D

G

P

G

A

Q

S

Q

L

F

D

Q

P

P

K

K

A

-

V

-

A

-

T

-

F

-

A

-

D

-

K

-

A

-

H

Q

E

A

Q

P

S

P

I

L

V

V

G

K

F

I

L

L

T

L

N

D

I

I

I

V

P

P

T

T

T

N

I

P

V

F

G

G

A

A

F

L

A

A

D

N

G

G

D

Q

I

V

L

L

Q

P

V

T

L

I

F

F

S

A

V

I

L

I

F

L

G

G

I

I

A

A

L

I

A

T

M

Y

-

L

-

M

-

N

-

S

-

E

-

N

-

E

-

K

V

V

G

R

E

K

K

S

G

A

E

E

Q

T

V

L

T

D

F

A

L

I

N

N

A

G

L

L

T

A

A

E

P

A

I

M

F

Y

K

K

L

I

V

V

G

N

I

G

L

V

M

M

K

Q

A

Y

A

A

P

P

I

I

G

G

A

V

F

F

G

A

A

L

M

I

A

A

F

Y

T

V

I

M

G

A

K

E

Y

Q

G

G

I

V

G

K

S

V

I

V

A

G

N

E

L

L

A

A

M

K

L

V

I

T

G

A

T

A

F

V

Y

Y

I

V

T

G

S

L

L

T

L

L

F

Q

V

I

L

L

V

L

V

V

L

Y

G

F

A

V

V

L

A

L

R

K

Y

I

N

Y

G

G

F

I

S

D

I

P

L

I

A

S

L

F

L

I

R

K

Y

K

I

A

K

K

E

D

E

A

L

M

L

L

L

T

V

A

L

F

G

V

T

T

S
x
R

S

S

S
|
S

E

S

A

G

A

T

L

L

P

P

G

V

L

T

M

M

N

R

K

V

M

A

E

K

K

E

A

M

G

G

C

I

K

S

R

E

S

G

V

I

V

Y

G

S

L

F

V

T

I

L

P

P

T

L

G

G

Y

A

S

T

F

I

N

N

L

M

D

D

G

G

T
|
T

N

A

I

L

Y

Y

M

Q

T

G

L

V

A

C

A

T

L

F

F

F

I

I

A

A

Q

N

A

A

T

L

G

G

I

S

Q

H

L

L

S

T

W

V

G

G

D

Q

Q

Q

I

L

L

T

L

I

L

V

L

L

V

T

A

A

M

V

L

L

S

A

S

-

K

-

G

-

A

-

G

-

I

-

T

-

G

-

A

-

G

-

F

-

I

I

T

M

L

L

A

A

A

M

T

V

L

L

S

E

V

S

V

V

-

G

-

L

-

P

-

L

-

T

-

D

P

P

S

N

V

V

P

-

V

A

A

A

G

A

M

Y

A

A

L

M

I

I

L

L

G

G

I

I

D

D

R

A

F

I

M

L

S
x
D

E

M

C

G

R

C

A
x
T

L

M

T

V

N
|
N

L

V

V

T

G

G

N

D

A

L

V

T

A

G

T

T

I

A

V

I

V

V

A

A

R

K

W

T

E

E

binding serine: R268 (≠ S280), S270 (= S282), T306 (= T318), D374 (≠ S393), T378 (≠ A397), N381 (= N400)

7awmA Structure of the thermostabilized eaat1 cryst mutant in complex with l-asp, three sodium ions and the allosteric inhibitor ucph101 (see paper)
31% identity, 87% coverage: 33:419/443 of query aligns to 33:407/412 of 7awmA

query
sites
7awmA

G

G

I

V

L

V

L

L

G

G

H

F

F

L

-

L

-

R

-

P

Y

Y

P

P

E

L

L

S

G

P

T

R

Q

E

L

V

K

K

P

Y

L

F

-

A

-

F

-

P

G

G

D

E

A

L

F

L

I

M

K

R

L

M

V

L

K

K

M

M

V

L

I

I

A

L

P

P

V

L

I

I

F

V

L

S

T

S

V

L

A

I

T

T

G

G

I

L

A

A

G

S

M

L

S

-

D

D

L

A

K

K

K

A

V
x
S

G
|
G

R

R

V

L

A
x
G

G

M

K

R

A
|
A

M
x
V

L

V

Y

Y

F
x
Y

L

M

T

S

F

T

S

T

T

I

L

I

A

A

L

V

V

V

I

L

G

G

M

I

I

I

V

L

A

V

N

L

V

I

Q

H

P

P

G

-

A

-

G

-

M

-

N

-

I

-

D

-

P

-

A

-

S

-

L

-

D

-

P

-

K

E

A

V

V

L

A

D

T

C

F

F

A

L

D

D

K

L

A

A

H

R

E

-

Q

-

S

-

I

-

V

-

G

-

F

-

L

-

T

-

N

N

I

I

I

F

P

P

T

S

T

N

I

L

V

V

G

S

A

A

-

A

-

F

-

R

-

S

-

Y

-

S

-

T

-

Q

F

E

A

V

D

E

G

G

-

M

D

N

I

I

L

L

Q

G

V

L

L

V

F

V

F

F

S

S

V
x
M

L

V

F

F

G

G

I
x
F

A

A

L

L

A

G

M

K

V

M

G

G

E

E

K

Q

G

G

E

Q

Q

L

V

L

V

V

T

D

F

F

L

F

N

N

A

S

L

L

T

N

A

E

P

A

I

T

F

M

K

K

L

L

V

V

G

A

I

I

L

I

M

M

K

W

A

Y

A

A

P

P

I

L

G

G

A

I

F

L

G

F

A

L

M

I

A

A

F

G

T

K

I

I

-

V

-

G

G

G

K

Q

Y

L

G

G

I

M

G

Y

S

M

I

V

A

T

N

V

L

I

A

V

M

G

L

L

I

V

G

-

T

-

F

-

Y

-

I

I

T

H

S

G

L

L

L

I

F

V

V

L

L

P

V

L

V

I

L

Y

G

F

A

L

V

I

A

T

R

R

Y

K

N

N

G

P

F

F

S

V

I

F

L

I

A

A

L

-

R

-

Y

G

I

I

K

L

E

Q

E

A

L

L

L

I

L

T

V

A

L

L

G

G

T

T

S

S

S
|
S

E

S

A

A

A

T

L

L

P

P

G

I

L

T

M

F

N

K

K

C

M

L

E

E

K

E

A

N

-

N

G

G

C

V

K

D

R

K

S

R

V

I

V

T

G

R

L
x
F

V

V

I

L

P

P

T
x
V

G

G

Y

A

S

T

F

I

N

N

L

M

D

D

G

G

T
|
T

N

A

I

L

Y

Y

M

E

T

A

L

V

A

A

L

I

F

F

I

I

A

A

Q

Q

A

V

T

N

G

N

I

Y

Q

E

L

L

S

D

W

F

G

G

D

Q

Q

I

I

I

L

T

L

I

L

S

L

I

V

T

A

A

M

T

L

A

S

A

S

S

K

I

G

G

A

A

G
|
G

I
|
I

T

P

G

Q

A
|
A

G
|
G

F

L

I

V

T

T

L

M

A

V

A

I

T

V

L

L

S

T

V

A

V

V

P

-

S

G

V

L

P

P

V

T

A

D

G

D

M

I

A

T

L

L

I

I

L

I

G

A

I

V

D

D

R

W

F

L

M

L

S
x
D

E

R

C

F

R
|
R

A
x
T

L

M

T

V

N

N

L

V

V

L

G

G

N

D

A

A

V

L

-

G

A

A

T

G

I

I

V

V

V

E

A

H

R

L

W

S

E

R

N

K

E

E

L

L

D

E

binding 2-Amino-5,6,7,8-tetrahydro-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-4H-chromene-3-carbonitrile: S88 (≠ V83), G89 (= G84), G92 (≠ A87), A95 (= A90), V96 (≠ M91), Y99 (≠ F94), M163 (≠ V171), F167 (≠ I175), F293 (≠ L305), V297 (≠ T309)
binding aspartic acid: S268 (= S281), S269 (= S282), T306 (= T318), G346 (= G358), I347 (= I359), A350 (= A362), G351 (= G363), D380 (≠ S393), R383 (= R396), T384 (≠ A397)

7xr6A Structure of human excitatory amino acid transporter 2 (eaat2) in complex with way-213613 (see paper)
30% identity, 89% coverage: 26:420/443 of query aligns to 20:420/424 of 7xr6A

query
sites
7xr6A

V
x
I

L

L

A

G

A

A

I

V

A

C

A

G

G

G

I

L

L

L

L

R

-

L

-

A

G

S

H

P

F

I

Y

H

P

P

E

D

L

V

G

V

T

M

Q

L

L

I

K

A

P

F

L

P

G

G

D

D

A

I

F

L

I

M

K

R

L

M

V

L

K

K

M

M

V

L

I

I

A

L

P

P

V

L

I

I

F

I

L

S

T

S

V

L

A

I

T

T

G

G

I

L

A

S

G

G

M

L

S

-

D

D

L

A

K

K

K

A

V

S

G

G

R
|
R

V

L

A

G

G

T

K
x
R

A

A

M

M

L

V

Y

Y

F

Y

L

M

T

S

F

T

S

T

T

I

L
x
I

A

A

L

A

V

V

I

L

G

G

M

V

I

I

V

L

A

V

N

L

V

A

V

I

Q

H

P

P

G

G

A

-

G

-

M

-

N

N

I

P

D

K

P

V

A

S

S

S

L

L

D

D

P

-

K

-

A

-

V

-

A

-

T

A

F

F

A

L

D

D

K

-

A

-

H

-

E

-

Q

-

S

-

I

-

V

-

G

-

F

L

L

I

T

R

N

N

I

L

I

F

P

P

T

E

T

N

I

L

V

V

G

Q

A

A

-

C

-

F

-

Q

-

I

-

Q

-

T

-

V

-

T

-

K

-

V

-

I

-

K

-

G

-

L

-

E

F

F

A

K

D

D

G

G

-

M

D

N

I

V

L

L

Q

G

V

L

L

I

F

G

F

F

S

F

V

I

L

A

F

F

G

G

I

I

A

A

L

M

A

G

M

K

V

M

G

G

E

D

K

Q

G

A

E

K

Q

L

V

M

V

V

T

D

F

F

L

F

N

N

A

I

L

L

T

N

A

E

P

I

I

V

F

M

K

K

L

L

V

V

G

I

I

M

L

I

M

M

K

W

A

Y

A

S

P

P

I

L

G

G

A

I

F

-

G

-

A

-

M

A

A

C

F

L

T

I

I

C

G

G

K

K

Y

I

-

I

G

A

I

I

G

K

S

D

I

L

A

E

N

V

L

V

A

A

M

R

L

Q

I

L

G

G

T

M

F

Y

Y

M

I

V

T

T

-

V

-

I

-

G

-

L

-

I

-

H

S

G

L

G

L

I

F

F

V

L

L

P

V

L

V
x
I

L

Y

G

F

A

V

V

V

A

T

R

R

Y

K

N

N

G

P

F

F

S

S

I

F

L

F

A

A

L

-

R

-

Y

G

I

I

K

F

E

Q

E

A

L

W

L

I

L

T

V

A

L

L

G

G

T

T

S

A

S
|
S

E

A

A

G

A

T

L

L

P

P

G

V

L

T

M

F

N

R

K

C

M

L

E

E

K

E

A

N

-

L

G

G

C

I

K

D

R

K

S

R

V

V

V

T

G

R

L

F

V

V

I

L

P

P

T

V

G

G

Y

A

S

T

F

I

N

N

L

M

D

D

G

G

T
|
T

N

A

I

L

Y

Y

M

E

T

A

L

V

A

A

L

I

F

F

I

I

A

A

Q

Q

A

M

T

N

G

G

I

V

Q

V

L

L

S

D

W

G

G

G

D

Q

Q

I

I

V

L

T

L

V

L

S

L

L

V

T

A

A

M

T

L

L

S

A

S

S

K

V

G

G

A

A

G

S

I

I

T

P

G

S

A

A

G
|
G

F

L

I

V

T

T

L
x
M

A

L

T

I

L

L

S

T

V

A

V

V

P

-

S

G

V

L

P

P

V

T

A

E

G

D

M

I

A

S

L

L

I

L

L
x
V

G

A

I

V

D
|
D

R
x
W

F

L

M

L

S

D

E

R

C

M

R
|
R

A
x
T

L

S

T

V

N

N

L

V

V

V

G

G

N

D

A

S

V

F

-

G

A

A

T

G

I

I

V

V

V

Y

A

H

R

L

W

S

E

K

N

S

E

E

L

L

D

D

T

T

binding (2S)-2-azanyl-4-[[4-[2-bromanyl-4,5-bis(fluoranyl)phenoxy]phenyl]amino]-4-oxidanylidene-butanoic acid: S280 (= S281), S281 (= S282), T318 (= T318), G363 (= G363), M367 (≠ L367), V385 (≠ L386), D388 (= D389), R395 (= R396), T396 (≠ A397)
binding dodecyl beta-D-glucopyranoside: I20 (≠ V26), W389 (≠ R390)
binding cholesterol hemisuccinate: R80 (= R85), R84 (≠ K89), I95 (≠ L100), I252 (≠ V250)

Sites not aligning to the query:

binding dodecyl beta-D-glucopyranoside: 16, 19

7xr4A Structure of human excitatory amino acid transporter 2 (eaat2) in complex with glutamate (see paper)
29% identity, 89% coverage: 26:420/443 of query aligns to 19:421/425 of 7xr4A

query
sites
7xr4A

V

I

L

L

A

G

A

A

I

V

A

C

A

G

G

G

I

L

L

L

L

R

-

L

-

A

G

S

H

P

F

I

Y

H

P

P

E

D

L

V

G

V

T

M

Q

L

L

I

K

A

P

F

L

P

G

G

D

D

A

I

F

L

I

M

K

R

L

M

V

L

K

K

M

M

V

L

I

I

A

L

P

P

V

L

I

I

F

I

L

S

T

S

V

L

A

I

T

T

G

G

I

L

A

S

G

G

M

L

S

-

D

D

L

A

K

K

K

A

V

S

G

G

R
|
R

V

L

A

G

G

T

K

R

A

A

M

M

L

V

Y

Y

F

Y

L

M

T

S

F

T

S

T

T

I

L

I

A

A

L

A

V

V

I

L

G

G

M

V

I

I

V

L

A

V

N

L

V

A

V

I

Q

H

P

P

G

G

A

-

G

-

M

-

N

N

I

P

D

K

P

V

A

S

S

S

L

L

D

D

P

-

K

-

A

-

V

-

A

-

T

A

F

F

A

L

D

D

K

-

A

-

H

-

E

-

Q

-

S

-

I

-

V

-

G

-

F

L

L

I

T

R

N

N

I

L

I

F

P

P

T

E

T

N

I

L

V

V

G

Q

A

A

-

C

-

F

-

Q

-

I

-

Q

-

T

-

V

-

T

-

K

-

V

-

I

-

K

-

G

-

L

-

E

F

F

A

K

D

D

G

G

-

M

D

N

I

V

L

L

Q

G

V

L

L

I

F

G

F

F

S

F

V

I

L

A

F

F

G

G

I

I

A

A

L

M

A

G

M

K

V

M

G

G

E

D

K

Q

G

A

E

K

Q

L

V

M

V

V

T

D

F

F

L

F

N

N

A

I

L

L

T

N

A

E

P

I

I

V

F

M

K

K

L

L

V

V

G

I

I

M

L

I

M

M

K

W

A

Y

A

S

P

P

I

L

G

G

A

I

F

-

G

-

A

-

M

A

A

C

F

L

T

I

I

C

G

G

K

K

Y

I

-

I

G

A

I

I

G

K

S

D

I

L

A

E

N

V

L

V

A

A

M

R

L

Q

I

L

G

G

T

M

F

Y

Y

M

I

V

T

T

-

V

-

I

-

G

-

L

-

I

-

H

S

G

L

G

L

I

F

F

V

L

L

P

V

L

V
x
I

L

Y

G

F

A

V

V

V

A

T

R

R

Y

K

N

N

G

P

F

F

S

S

I

F

L

F

A

A

L

-

R

-

Y

G

I

I

K

F

E

Q

E

A

L

W

L

I

L

T

V

A

L

L

G

G

T

T

S

A

S

S

S
|
S

E

A

A

G

A

T

L

L

P

P

G

V

L

T

M

F

N

R

K

C

M

L

E

E

K

E

A

N

-

L

G

G

C

I

K

D

R

K

S

R

V

V

V

T

G

R

L

F

V

V

I

L

P

P

T

V

G

G

Y

A

S

T

F

I

N

N

L
x
M

D

D

G

G

T
|
T

N

A

I

L

Y

Y

M

E

T

A

L

V

A

A

L

I

F

F

I

I

A

A

Q

Q

A

M

T

N

G

G

I

V

Q

V

L

L

S

D

W

G

G

G

D

Q

Q

I

I

V

L

T

L

V

L

S

L

L

V

T

A

A

M

T

L

L

S

A

S

S

K

V

G

G

A

A

G
x
S

I

I

T

P

G

S

A

A

G
|
G

F

L

I

V

T

T

L

M

A

L

T

I

L

L

S

T

V

A

V

V

P

-

S

G

V

L

P

P

V

T

A

E

G

D

M

I

A

S

L

L

I

L

L

V

G

A

I

V

D

D

R

W

F

L

M

L

S
x
D

E

R

C

M

R
|
R

A
x
T

L

S

T

V

N
|
N

L

V

V

V

G

G

N

D

A

S

V

F

-

G

A

A

T

G

I

I

V

V

V

Y

A

H

R

L

W

S

E

K

N

S

E

E

L

L

D

D

T

T

binding glutamic acid: S282 (= S282), M316 (≠ L315), T319 (= T318), S359 (≠ G358), G364 (= G363), D393 (≠ S393), R396 (= R396), T397 (≠ A397), N400 (= N400)
binding cholesterol hemisuccinate: R79 (= R85), I253 (≠ V250)

7vr7A Inward-facing structure of human eaat2 in the way213613-bound state (see paper)
29% identity, 86% coverage: 26:405/443 of query aligns to 12:389/402 of 7vr7A

query
sites
7vr7A

V

I

L

L

A

G

A

A

I

V

A

C

A

G

G

G

I

L

L

L

L

R

-

L

-

A

G

S

H

P

F

I

Y

H

P

P

E

D

L

V

G

V

T

M

Q

L

L

I

K

A

P

F

L

P

G

G

D

D

A

I

F

L

I

M

K

R

L

M

V

L

K

K

M

M

V

L

I

I

A

L

P

P

V

L

I

I

F

I

L

S

T
x
S

V
x
L

A

I

T

T

G

G

I

L

A

S

G

G

M
x
L

S

D

D

-

L

-

K

-

V

-

G

G

R

R

V

L

A

G

G

T

K

R

A

A

M

M

L

V

Y

Y

F

Y

L

M

T

S

F

T

S

T

T

I

L

I

A

A

L

A

V

V

I

L

G

G

M

V

I

I

V

L

A

V

N

L

V

A

V

I

Q

H

P

P

G

G

A

-

G

-

M

-

N

-

I

-

D

N

P

P

A

S

S

S

L

L

D

D

P

-

K

-

A

-

V

-

A

-

T

A

F

F

A

L

D

D

K

-

A

-

H

-

E

-

Q

-

S

-

I

-

V

-

G

-

F

L

L

I

T

R

N

N

I

L

I

F

P

P

T

E

T

N

I

L

V

V

G

Q

A

A

-

C

-

F

-

Q

-

I

-

Q

-

T

-

V

-

T

-

K

-

I

-

K

-

G

-

L

-

E

F

F

A

K

D

D

G

G

-

M

D

N

I

V

L

L

Q

G

V

L

L

I

F

G

F

F

S

F

V

I

L

A

F

F

G

G

I

I

A

A

L

M

A

G

M

K

V

M

G

G

E

D

K

Q

G

A

E

K

Q

L

V

M

V

V

T

D

F

F

L

F

N

N

A

I

L

L

T

N

A

E

P

I

I

V

F

M

K

K

L

L

V

V

G

I

I

M

L

I

M

M

K
x
W

A

Y

A

S

P

P

I

L

G

G

A

I

F

-

G

-

A

-

M

A

A

C

F

L

T

I

I

C

G

G

K

K

Y

I

-

I

G

A

I

I

G

K

S

D

I

L

A

E

N

V

L

V

A

A

M

R

L

Q

I

L

G

G

T

M

F

Y

Y

M

I

V

T

T

-

V

-

I

-

G

-

L

-
x
I

-

I

-

H

S

G

L

G

L

I

F

F

V

L

L

P

V

L

V

I

L

Y

G

F

A

V

V

V

A

T

R

R

Y

K

N

N

G

P

F

F

S

S

I

F

L
x
F

A

A

L

-

R

-

Y

G

I

I

K

F

E

Q

E

A

L
x
W

L

I

L

T

V

A

L

L

G

G

T

T

S

A

S

S

S
|
S

E

A

A

G

A

T

L

L

P

P

G

V

L

T

M

F

N

R

K

C

M

L

E

E

K

E

A

N

-

L

G

G

C

I

K

D

R

K

S

R

V

V

V

T

G

R

L

F

V

V

I

L

P

P

T

V

G

G

Y

A

S

T

F

I

N

N

L
x
M

D

D

G

G

T
|
T

N

A

I

L

Y
|
Y

M

E

T

A

L

V

A

A

L

I

F

F

I

I

A

A

Q

Q

A

M

T

N

G

G

I

V

Q

V

L

L

S

D

W

G

G

G

D

Q

Q

I

I

V

L

T

L

V

L

S

L

L

V

T

A

A

M

T

L

L

S

A

S

S

K
x
V

G
|
G

A

A

G
x
S

I
|
I

T

P

G

S

A

A

G
|
G

F
x
L

I

V

T

T

L
x
M

A

L

T

I

L

L

S

T

V

A

V

V

P

-

S

G

V

L

P

P

V

T

A

E

G

D

M
x
I

A

S

L

L

I
x
L

L
x
V

G

A

I

V

D
|
D

R

W

F

L

M

L

S
x
D

E

R

C
x
M

R
|
R

A
x
T

L
x
S

T

V

N
|
N

L

V

V

V

G

G

N

D

A

S

binding (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en: S57 (≠ T69), L58 (≠ V70), L65 (≠ M77), V339 (≠ K354), G340 (= G355), S343 (≠ G358), I344 (= I359)
binding cholesterol: W188 (≠ K207), I227 (vs. gap), F250 (≠ L263), W257 (≠ L273), M379 (≠ C395), S382 (≠ L398)
binding (2S)-2-azanyl-4-[[4-[2-bromanyl-4,5-bis(fluoranyl)phenoxy]phenyl]amino]-4-oxidanylidene-butanoic acid: S266 (= S282), M300 (≠ L315), T303 (= T318), Y306 (= Y321), G348 (= G363), L349 (≠ F364), M352 (≠ L367), I366 (≠ M382), L369 (≠ I385), V370 (≠ L386), D373 (= D389), D377 (≠ S393), R380 (= R396), T381 (≠ A397), N384 (= N400)

Sites not aligning to the query:

binding cholesterol: 2

P43006 Excitatory amino acid transporter 2; GLT-1; Sodium-dependent glutamate/aspartate transporter 2; Solute carrier family 1 member 2 from Mus musculus (Mouse) (see paper)
27% identity, 93% coverage: 26:439/443 of query aligns to 55:521/572 of P43006

query
sites
P43006

V

I

L

L

A

G

A

A

I

V

A

C

A

G

G

G

I

L

L

L

L

R

-

L

-

A

G

S

H

P

F

I

Y

H

P

P

E

D

L

V

G

V

T

M

Q

L

L

I

K

A

P

F

L

P

G

G

D

D

A

I

F

L

I

M

K

R

L

M

V

L

K

K

M

M

V

L

I

I

A

L

P

P

V

L

I

I

F

I

L

S

T

S

V

L

A

I

T

T

G

G

I

L

A

S

G

G

M

L

S

-

D

D

L

A

K

K

K

A

V

S

G

G

R

R

V

L

A

G

G

T

K

R

A

A

M

M

L

V

Y

Y

F

Y

L

M

T

S

F

T

S

T

T

I

L

I

A

A

L

A

V

V

I

L

G

G

M

V

I

I

V

L

A

V

N

L

V

A

V

I

Q

H

P

P

G

G

-

N

-

P

-

K

-

L

-

K

-

Q

-

L

-

G

-

P

A

G

G

K

M

K

N

N

I

D

D

E

P

V

A

S

S

S

L

L

D

D

P

A

-

F

-

L

-

D

-

L

-

I

-

R

-

N

-

L

-

F

-

P

-

E

-

N

-

L

-

V

-

Q

-

A

-

C

-

F

K

Q

A

Q

V

I

A

Q

T

T

F

V

A

T

D

K

K

K

-

V

-

L

-

V

-

A

-

P

A

S

H

E

E

E

Q

A

S

N

I

T

V

T

G

K

F

A

L

V

T

I

N

S

I

M

I

L

P

N

T

E

T

T

I

M

V

N

G

E

A

A

-

P

-

E

-

T

-

K

-

I

-

V

-

I

-

K

-

G

-

L

-

E

F

F

A

K

D

D

G

G

-

M

D

N

I

V

L

L

Q

G

V

L

L

I

F

G

F

F

S

F

V

I

L

A

F

F

G

G

I

I

A

A

L

M

A

G

M

K

V

M

G

G

E

E

K

Q

G

A

E

K

Q

L

V

M

V

V

T

E

F

F

L

F

N

N

A

I

L

L

T

N

A

E

P

I

I

V

F

M

K

K

L

L

V

V

G

I

I

M

L

I

M

M

K

W

A

Y

A

S

P

P

I

L

G

G

A

I

F

-

G

-

A

-

M

A

A

C

F

L

T

I

I

C

G

G

K

K

Y

I

-

I

G

A

I

I

G

K

S

D

I

L

A

E

N

V

L

V

A

A

M

R

L

Q

I

L

G

G

T

M

F

Y

Y

M

I

I

T

T

S

V

L

I

-

V

-

G

-

L

-

I

-

H

-

G

L

I

F

F

V

L

L

P

V

L

V

I

L

Y

G

F

A

V

V

V

A

T

R

R

Y

K

N

N

G

P

F

F

S

S

I

F

L

F

A

A

L

-

R

-

Y

G

I

I

K

F

E

Q

E

A

L

W

L

I

L

T

V

A

L

L

G

G

T

T

S

A

S

S

E

A

A

G

A

T

L

L

P

P

G

V

L

T

M

F

N

R

K

C

M

L

E

E

K

D

A

N

-

L

G

G

C

I

K

D

R

K

S

R

V

V

V

T

G

R

L

F

V

V

I

L

P

P

T

V

G

G

Y

A

S

T

F

I

N

N

L

M

D

D

G

G

T

T

N

A

I

L

Y

Y

M

E

T

A

L

V

A

A

L

I

F

F

I

I

A

A

Q

Q

A

M

T

N

G

G

I

V

Q

I

L

L

S

D

W

G

G

G

D

Q

Q

I

I

V

L

T

L

V

L

S

L

L

V

T

A

A

M

T

L

L

S

A

S

S

K

I

G

G

A

A

G

S

I

I

T

P

G

S

A

A

G

G

F

L

I

V

T

T

L

M

A

L

T

I

L

L

S

T

V

A

V

V

P

-

S

G

V

L

P

P

V

T

A

E

G

D

M

I

A

S

L

L

I

L

L

V

G

A

I

V

D

D

R

W

F

L

M

L

S

D

E

R

C

M

R

R

A

T

L

S

T

V

N

N

L

V

V

V

G

G

N

D

A

S

V

F

-

G

A

A

T

G

I

I

V

V

V

Y

A

H

R

L

W

S

E

K

N

S

E

E

L

L

D

D

T

T

G

I

Q

D

L

S

A

Q

R

H

A

R

L

M

G

Q

G

E

E

D

S

I

E

E

D

M

T

T

S

K

T

T

A

Q

G

S

L

I

Sites not aligning to the query:

38 modified: S-palmitoyl cysteine; C→S: Severely impairs glutamate uptake activity.

P31596 Excitatory amino acid transporter 2; GLT-1; Sodium-dependent glutamate/aspartate transporter 2; GLUT-R; Solute carrier family 1 member 2 from Rattus norvegicus (Rat) (see paper)
28% identity, 93% coverage: 26:436/443 of query aligns to 55:518/573 of P31596

query
sites
P31596

V

I

L

L

A

G

A

A

I

V

A

C

A

G

G

G

I

L

L

L

L

R

-

L

-

A

G

A

H

P

F

I

Y

H

P

P

E

D

L

V

G

V

T

M

Q

L

L

I

K

A

P

F

L

P

G

G

D

D

A

I

F

L

I

M

K

R

L

M

V

L

K

K

M

M

V

L

I

I

A

L

P

P

V

L

I

I

F

I

L

S

T

S

V

L

A

I

T

T

G

G

I

L

A

S

G

G

M

L

S

-

D

D

L

A

K

K

K

A

V

S

G

G

R

R

V

L

A

G

G

T

K

R

A

A

M

M

L

V

Y

Y

F

Y

L

M

T

S

F

T

S

T

T

I

L

I

A

A

L

A

V

V

I

L

G

G

M

V

I

I

V

L

A

V

N

L

V

A

V

I

Q

H

P

P

G

G

-

N

-

P

-

K

-

L

-

K

-

Q

-

L

-

G

-

P

A

G

G

K

M

K

N

N

I

D

D

E

P

V

A

S

S

S

L

L

D

D

P

A

-

F

-

L

-

D

-

L

-

I

-

R

-

N

-

L

-

F

-

P

-

E

-

N

-

L

-

V

-

Q

-

A

-

C

-

F

K

Q

A

Q

V

I

A

Q

T

T

F

V

A

T

D

K

K

K

-

V

-

L

-

V

-

A

-

P

A

S

H

E

E

E

Q

A

S

N

I

T

V

T

G

K

F

A

L

V

T

I

N

S

I

L

P

N

T

E

T

T

I

M

V

N

G

E

A

A

-

P

-

E

-

T

-

K

-

I

-

V

-

I

-

K

-

G

-

L

-

E

F

F

A

K

D

D

G

G

-

M

D

N

I

V

L

L

Q

G

V

L

L

I

F

G

F

F

S

F

V

I

L

A

F

F

G

G

I

I

A

A

L

M

A

G

M

K

V

M

G

G

E

E

K

Q

G

A

E

K

Q

L

V

M

V

V

T

E

F

F

L

F

N

N

A

I

L

L

T

N

A

E

P

I

I

V

F

M

K

K

L

L

V

V

G

I

I

M

L

I

M

M

K

W

A

Y

A

S

P

P

I

L

G

G

A

I

F

-

G

-

A

-

M

A

A

C

F

L

T

I

I

C

G

G

K
|
K

Y

I

-

I

G

A

I

I

G

K

S

D

I

L

A

E

N

V

L

V

A

A

M

R

L

Q

I

L

G

G

T

M

F

Y

Y

M

I

I

T

T

S

V

L

I

-

V

-

G

-

L

-

I

-
x
H

-

G

L

I

F

F

V

L

L

P

V

L

V

I

L

Y

G

F

A

V

V

V

A

T

R

R

Y

K

N

N

G

P

F

F

S

S

I

F

L

F

A

A

L

-

R

-

Y

G

I

I

K

F

E

Q

E

A

L

W

L

I

L

T

V

A

L

L

G

G

T

T

S

A

S

S

E

A

A

G

A

T

L

L

P

P

G

V

L

T

M

F

N

R

K

C

M

L

E

E

K

D

A

N

-

L

G

G

C

I

K

D

R

K

S

R

V

V

V

T

G

R

L

F

V

V

I

L

P

P

T

V

G

G

Y

A

S

T

F

I

N

N

L

M

D

D

G

G

T

T

N

A

I

L

Y

Y

M

E

T

A

L

V

A

A

L

I

F

F

I

I

A

A

Q

Q

A

M

T

N

G

G

I

V

Q

I

L

L

S

D

W

G

G

G

D

Q

Q

I

I

V

L

T

L

V

L

S

L

L

V

T

A

A

M

T

L

L

S

A

S

S

K

I

G

G

A

A

G

S

I

I

T

P

G

S

A

A

G

G

F

L

I

V

T

T

L

M

A

L

T

I

L

L

S

T

V

A

V

V

P

-

S

G

V

L

P

P

V

T

A

E

G

D

M

I

A

S

L

L

I

L

L

V

G

A

I

V

D

D

R

W

F

L

M

L

S

D

E

R

C

M

R

R

A

T

L

S

T

V

N

N

L

V

V

V

G

G

N

D

A

S

V

F

-

G

A

A

T

G

I

I

V

V

V

Y

A

H

R

L

W

S

E

K

N

S

E

E

L

L

D

D

T

T

G

I

Q

D

L

S

A

Q

R

H

A

R

L

M

G

H

G

E

E

D

S

I

E

E

D

M

T

T

S

K

T

T

K298 (= K223) mutation K->H,R: Normal transporter activity.; mutation K->N,T: Reduced transporter activity.
H326 (vs. gap) mutation H->N,T,K,R: No transporter activity.

5mjuA Structure of the thermostabilized eaat1 cryst mutant in complex with the competititve inhibitor tfb-tboa and the allosteric inhibitor ucph101 (see paper)
30% identity, 87% coverage: 33:419/443 of query aligns to 25:393/397 of 5mjuA

query
sites
5mjuA

G

G

I

V

L

V

L

L

G

G

H

F

F

L

-

L

-

R

-

P

Y

Y

P

P

E

L

L

S

G

P

T

R

Q

E

L

V

K

K

P

Y

L

F

-

A

-

F

-

P

G

G

D

E

A

L

F

L

I

M

K

R

L

M

V

L

K

K

M

M

V

L

I

I

A

L

P

P

V

L

I
|
I

F

V

L

S

T

S

V

L

A

I

T

T

G

G

I
x
L

A

A

G

S

M

L

S

-

D

D

L

A

K

K

K

A

V
x
S

G
|
G

R

R

V

L

A
x
G

G

M

K

R

A

A

M

V

L

V

Y

Y

F
x
Y

L

M

T

S

F

T

S

T

T

I

L

I

A

A

L

V

V

V

I

L

G

G

M

I

I

I

V

L

A

V

N

L

V

I

Q

H

P

E

-

V

-

L

-

D

-

C

-

F

-

L

G

D

A

L

G

A

M

R

N

N

I

I

D

F

P

P

A

S

S

N

L

L

D

V

P

S

K

A

A

A

V

F

A

R

T

S

F

Y

A

S

D

T

K

T

A

G

H

Q

E

E

Q

-

S

-

I

-

V

-

G

-

F

-

L

-

T

-

N

-

I

-

P

-

T

-

I

-

V

-

G

-

A

-

F

-

A

V

D

E

G

G

-

M

D

N

I
|
I

L

L

Q

G

V

L

L

V

F

V

F

F

S

S

V
x
M

L

V

F

F

G

G

I
x
F

A

A

L

L

A

G

M

K

V

M

G

G

E

E

K

Q

G

G

E

Q

Q

L

V

L

V

V

T

D

F

F

L

F

N

N

A

S

L

L

T

N

A

E

P

A

I

T

F

M

K

K

L

L

V

V

G

A

I

I

L

I

M

M

K

W

A

Y

A

A

P

P

I

L

G

G

A

I

F

L

G

F

A

L

M

I

A

A

F

G

T

K

I

I

-

V

-

E

G

G

K

Q

Y

L

G

G

I

M

G

Y

S

M

I

V

A

T

N

V

L

I

A

V

M

G

L

L

I

V

G

-

T

-

F

-

Y

-

I

I

T

H

S

G

L

L

L

I

F

V

V

L

L

P

V

L

V

I

L

Y

G

F

A

L

V

I

A

T

R

R

Y

K

N

N

G

P

F

F

S

V

I

F

L

I

A

A

L

-

R

-

Y

G

I

I

K

L

E

Q

E

A

L

L

L

I

L

T

V

A

L

L

G

G

T

T

S

S

S
|
S

E
x
S

A

A

A

T

L

L

P

P

G

I

L

T

M

F

N

K

K

C

M

L

E

E

K

E

-

N

A

N

G

G

C

V

K

D

R

K

S

R

V

I

V

T

G

R

L
x
F

V

V

I

L

P

P

T
x
V

G

G

Y
x
A

S
x
T

F

I

N

N

L
x
M

D

D

G

G

T
|
T

N

A

I

L

Y

Y

M

E

T

A

L

V

A

A

L

I

F

F

I

I

A

A

Q

Q

A

V

T

N

G

Q

I

I

Q

-

L

-

S

-

W

-

G

-

D

-

Q

-

I

I

L

T

L

I

L

S

L

I

V

T

A

A

M

T

L

A

S

A

S

S

K

I

G
|
G

A

A

G

G

I

I

T

P

G

Q

A
|
A

G
|
G

F

L

I

V

T

T

L

M

A

V

A

I

T

V

L

L

S

T

V

A

V

V

P

-

S

G

V

L

P

P

V

T

A

D

G

D

M

I

A

T

L

L

I

I

L

I

G

A

I

V

D

D

R

W

F

L

M

L

S
x
D

E

R

C

F

R
|
R

A

T

L

M

T

V

N
|
N

L

V

V

L

G

G

N

D

A

A

V

L

-

G

A

A

T

G

I

I

V

V

V

E

A

H

R

L

W

S

E

R

N

K

E

E

L

L

D

E

binding 2-Amino-5,6,7,8-tetrahydro-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-4H-chromene-3-carbonitrile: L72 (≠ I74), S80 (≠ V83), G81 (= G84), G84 (≠ A87), Y91 (≠ F94), M156 (≠ V171), F160 (≠ I175), F286 (≠ L305), V290 (≠ T309)
binding (2~{S},3~{S})-2-azanyl-3-[[3-[[4-(trifluoromethyl)phenyl]carbonylamino]phenyl]methoxy]butanedioic acid: I64 (= I66), I148 (= I163), S262 (= S282), S263 (≠ E283), A292 (≠ Y311), T293 (≠ S312), M296 (≠ L315), T299 (= T318), G329 (= G355), A336 (= A362), G337 (= G363), D366 (≠ S393), R369 (= R396), N373 (= N400)

Q10901 Excitatory amino acid transporter; Sodium-dependent glutamate/ aspartate transporter from Caenorhabditis elegans (see paper)
26% identity, 90% coverage: 22:419/443 of query aligns to 21:465/503 of Q10901

query
sites
Q10901

L

L

Y

L

V

V

Q

L

V

T

L

V

A

S

I

V

A

V

A

L

G

G

I

A

L

L

L

C

G

G

H

F

F

L

Y

L

P

R

E

-

L

-

G

G

T

L

Q

Q

L

L

K

S

P

P

L

Q

-

N

-

I

-

M

-

Y

-

I

-

S

-

F

-

P

G

G

D

E

A

L

F

L

I

M

K

H

L

M

V

L

K

K

M

M

V

M

I

I

A

L

P

P

V

L

I

I

F

M

L

S

T

S

V

L

A

I

T

S

G

G

I

L

A

A

G

Q

M

L

S

-

D

D

L

A

K

R

K

Q

V

S

G

G

R

K

V

L

A

G

G

S

K

L

A

A

M

V

L

T

Y

Y

F

Y

L

M

T

F

F

T

S

T

T

A

L

V

A

A

L

V

V

V

I

T

G

G

M

I

I

F

V

L

A

V

N

L

V

V

V

I

Q

H

P

P

G

G

A

-

G

-

M

-

N

-

I

-

D

D

P

P

A

T

-

I

-

K

-

E

-

I

-

G

-

T

S

G

L

T

D

E

P

G

K

K

A

T

V

V

A

S

T

T

F

V

A

-

D

-

K

-

A

-

H

-

E

-

Q

D

S

T

I

L

V

L

G

D

F

L

L

L

T

R

N

N

I

M

I

F

P

P

T

E

T

N

I

V

V

V

G

Q

A

A

-

T

-

F

-

Q

-

V

-

Q

-

T

-

K

-

Y

-

I

-

K

-

V

-

R

-

P

-

K

-

V

-

K

-

N

-
x
N

-

D

-

S

-

A

-

T

-

L

-

A

-

L

-

N

-
x
N

-

G

-

S

-

L

-

D

-

Y

-

V

-

K

-

A

-

S

-

V

-

E

F

Y

A

T

D

S

G

G

-

M

D

N

I

V

L

L

Q

G

V

V

L

I

F

V

F

F

S

C

V

I

L

A

F

I

G

G

I

I

A

S

L

L

A

S

M

Q

V

L

G

G

E

Q

K

E

G

A

E

H

Q

V

V

M

V

V

T

Q

F

F

L

F

N

V

A

I

L

M

T

D

A

K

P

V

I

I

F

M

K

K

L

L

V

V

G

M

I

T

L

V

M

M

K

W

A

Y

A

S

P

P

I

F

G

G

A

I

F

F

G

-

A

-

M

-

A

C

F

L

T

I

I

M

G

G

K

K

-

I

Y

L

G

E

I

I

G

H

S

D

I

L

A

A

N

D

L

T

A

A

M

R

L

M

I

L

G

A

T

M

F

Y

Y

M

I

V

T

T

-

V

-

L

-

S

-

G

-

L

-

A

-

I

-

H

S

S

L

L

L

I

F

S

V

L

L

P

V

L

V

I

L

F

G

F

A

V

V

T

A

T

R

K

Y

K

N

N

G

P

F

Y

S

-

I

-

L

-

A

V

L

F

L

M

R

R

Y

G

I

L

K

F

E

Q

E

A

L

W

L

I

L

T

V

A

L

L

G

G

T

T

S

A

S

S

E

S

A

A

A

T

L

L

P

P

G

I

L

T

M

F

N

N

K

C

M

L

E

E

K

E

A

N

-

L

G

G

C

V

K

D

R

R

S

R

V

V

V

T

G

R

L

F

V

V

I

L

P

P

T

V

G

G

Y

A

S

T

F

I

N

N

L

M

D

D

G

G

T

T

N

A

I

L

Y

Y

M

E

T

A

L

V

A

A

L

I

F

F

I

I

A

A

Q

Q

A

I

T

N

G

G

I

V

Q

H

L

L

S

S

W

F

G

G

D

Q

Q

V

I

V

L

T

L

V

L

S

L

L

V

T

A

A

M

T

L

L

S

A

S

S

K

I

G

G

A

A

G

S

I

V

T

P

G

S

A

A

G

G

F

L

I

V

T

T

L

M

A

L

T

V

L

L

S

T

V

A

V

V

P

-

S

G

V

L

P

P

V

V

A

K

G

D

M

V

A

S

L

L

I

I

L

V

G

A

I

V

D

D

R

W

F

L

M

L

S

D

E

R

C

I

R

R

A

T

L

S

T

I

N

N

L

V

V

L

G

G

N

D

A

A

V

M

A

G

T

A

I

G

V

I

V

V

A

Y

R

H

W

Y

E

S

N

K

-

A

E

D

L

L

D

D

N177 (vs. gap) modified: carbohydrate, N-linked (GlcNAc...) asparagine
N187 (vs. gap) modified: carbohydrate, N-linked (GlcNAc...) asparagine

Query Sequence

>WP_011426214.1 NCBI__GCF_000092045.1:WP_011426214.1
MIAAPLDAVADSKGKKPFYSHLYVQVLAAIAAGILLGHFYPELGTQLKPLGDAFIKLVKM
VIAPVIFLTVATGIAGMSDLKKVGRVAGKAMLYFLTFSTLALVIGMIVANVVQPGAGMNI
DPASLDPKAVATFADKAHEQSIVGFLTNIIPTTIVGAFADGDILQVLFFSVLFGIALAMV
GEKGEQVVTFLNALTAPIFKLVGILMKAAPIGAFGAMAFTIGKYGIGSIANLAMLIGTFY
ITSLLFVLVVLGAVARYNGFSILALLRYIKEELLLVLGTSSSEAALPGLMNKMEKAGCKR
SVVGLVIPTGYSFNLDGTNIYMTLAALFIAQATGIQLSWGDQILLLLVAMLSSKGAAGIT
GAGFITLAATLSVVPSVPVAGMALILGIDRFMSECRALTNLVGNAVATIVVARWENELDT
GQLARALGGESEDTSTAGLQPAE

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory