SitesBLAST
Comparing WP_011427241.1 NCBI__GCF_000092045.1:WP_011427241.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
6dbbA Crystal structure of a putative aldehyde dehydrogenase family protein burkholderia cenocepacia j2315 in complex with partially reduced nadh
68% identity, 97% coverage: 15:511/512 of query aligns to 7:504/504 of 6dbbA
- active site: N152 (= N160), E259 (= E266), C293 (= C300), E471 (= E478)
- binding nicotinamide-adenine-dinucleotide: I148 (= I156), S149 (= S157), A150 (= A158), F151 (= F159), N152 (= N160), K175 (= K183), S177 (= S185), R218 (= R225), T236 (= T243), G237 (= G244), S238 (= S245), M241 (= M248), E259 (= E266), L260 (= L267), G261 (= G268), C293 (= C300), E391 (= E398), F393 (= F400)
- binding beta-6-hydroxy-1,4,5,6-tetrhydronicotinamide adenine dinucleotide: I148 (= I156), S149 (= S157), A150 (= A158), F151 (= F159), N152 (= N160), K175 (= K183), S177 (= S185), R218 (= R225), T236 (= T243), G237 (= G244), S238 (= S245), M241 (= M248), E259 (= E266), L260 (= L267), G261 (= G268), C293 (= C300), E391 (= E398), F393 (= F400)
6rtsA Piperideine-6-carboxylate dehydrogenase from streptomyces clavuligerus complexed with NAD+ (see paper)
60% identity, 97% coverage: 14:509/512 of query aligns to 16:508/509 of 6rtsA
- active site: N162 (= N160), E263 (= E266), C297 (= C300), E477 (= E478)
- binding nicotinamide-adenine-dinucleotide: I158 (= I156), S159 (= S157), A160 (= A158), F161 (= F159), N162 (= N160), K185 (= K183), S187 (= S185), E188 (= E186), A222 (≠ R225), G225 (= G228), T240 (= T243), G241 (= G244), S242 (= S245), M245 (= M248), E263 (= E266), L264 (= L267), C297 (= C300), E397 (= E398), F399 (= F400)
6rttA Piperideine-6-carboxylate dehydrogenase from streptomyces clavuligerus complexed with picolinic acid (see paper)
60% identity, 97% coverage: 14:509/512 of query aligns to 15:507/508 of 6rttA
- active site: N161 (= N160), E262 (= E266), C296 (= C300), E476 (= E478)
- binding pyridine-2-carboxylic acid: A159 (= A158), F162 (= F161), V166 (= V165), W169 (= W168), G240 (= G244), S241 (= S245), R295 (= R299), C296 (= C300), T297 (= T301), E396 (= E398), F398 (= F400), P421 (= P423), K469 (= K471), E470 (= E472)
6rtuA Piperideine-6-carboxylate dehydrogenase from streptomyces clavuligerus complexed with alpha-aminoadipic acid (see paper)
60% identity, 97% coverage: 14:509/512 of query aligns to 15:504/505 of 6rtuA
- active site: N161 (= N160), E259 (= E266), C293 (= C300), E473 (= E478)
- binding 2-aminohexanedioic acid: E115 (= E114), F162 (= F161), R292 (= R299), C293 (= C300), T294 (= T301), S454 (= S459), G455 (= G460), A456 (= A461), F462 (= F467)
4zulA Structure aldh7a1 complexed with alpha-aminoadipate (see paper)
48% identity, 97% coverage: 16:510/512 of query aligns to 12:509/509 of 4zulA
- active site: N165 (= N160), K188 (= K183), E266 (= E266), C300 (= C300), E397 (= E398), E477 (= E478)
- binding 2-aminohexanedioic acid: E119 (= E114), F166 (= F161), R299 (= R299), C300 (= C300), T301 (= T301), G459 (= G460), A460 (= A461), F466 (= F467)
4x0tA Structure aldh7a1 inactivated by 4-diethylaminobenzaldehyde and complexed with NAD+ (see paper)
48% identity, 97% coverage: 16:510/512 of query aligns to 12:509/509 of 4x0tA
- active site: N165 (= N160), K188 (= K183), E266 (= E266), C300 (= C300), E397 (= E398), E477 (= E478)
- binding 4-(diethylamino)benzaldehyde: F166 (= F161), V170 (= V165), W173 (= W168), C300 (= C300), F466 (= F467)
- binding nicotinamide-adenine-dinucleotide: T162 (≠ S157), A163 (= A158), F164 (= F159), N165 (= N160), K188 (= K183), G189 (≠ P184), A190 (≠ S185), A225 (≠ R225), G228 (= G228), T229 (≠ E229), F242 (≠ A242), T243 (= T243), G244 (= G244), S245 (= S245), V248 (≠ M248), E266 (= E266), L267 (= L267), C300 (= C300), E397 (= E398), F399 (= F400)
P49419 Alpha-aminoadipic semialdehyde dehydrogenase; Alpha-AASA dehydrogenase; Aldehyde dehydrogenase family 7 member A1; Antiquitin-1; Betaine aldehyde dehydrogenase; Delta1-piperideine-6-carboxylate dehydrogenase; P6c dehydrogenase; EC 1.2.1.31; EC 1.2.1.3; EC 1.2.1.8 from Homo sapiens (Human) (see 5 papers)
48% identity, 97% coverage: 16:510/512 of query aligns to 42:539/539 of P49419
- 110:539 (vs. 75:510, 51% identical) natural variant: Missing (in EPEO4; loss of alpha-AASA dehydrogenase activity)
- TAF 192:194 (≠ SAF 157:159) binding NAD(+)
- A199 (= A164) to V: in EPEO4; loss of alpha-AASA dehydrogenase activity; dbSNP:rs121912709
- K218 (= K183) binding NAD(+)
- GT 258:259 (≠ GE 228:229) binding NAD(+)
- GS 274:275 (= GS 244:245) binding NAD(+)
- EL 296:297 (= EL 266:267) binding NAD(+)
- C330 (= C300) active site, Nucleophile
- E427 (= E398) binding NAD(+); to Q: in EPEO4; loss of alpha-AASA dehydrogenase activity; dbSNP:rs121912707
- K439 (≠ S410) to Q: in dbSNP:rs12514417
6o4dB Structure of aldh7a1 mutant w175a complexed with l-pipecolic acid (see paper)
48% identity, 97% coverage: 16:510/512 of query aligns to 13:510/510 of 6o4dB