SitesBLAST – Find functional sites

 

SitesBLAST

Comparing WP_011427992.1 NCBI__GCF_000092045.1:WP_011427992.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 8 hits to proteins with known functional sites (download)

Q01468 2-hydroxymuconate tautomerase; 4-oxalocrotonate tautomerase; 4-OT; EC 5.3.2.6 from Pseudomonas putida (Arthrobacter siderocapsulatus) (see 2 papers)
42% identity, 98% coverage: 1:60/61 of query aligns to 1:60/63 of Q01468

query
sites
Q01468
M
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M
P
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P
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I
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A
H
 
Q
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I
Q
 
H
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E
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G
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E
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P
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L
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E
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M
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A
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I
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G
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G
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E
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K

6bgnA Crystal structure of 4-oxalocrotonate tautomerase after incubation with 5-fluoro-2-hydroxy-2,4-pentadienoate (see paper)
41% identity, 97% coverage: 2:60/61 of query aligns to 1:59/59 of 6bgnA

query
sites
6bgnA
P
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P
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A
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Q
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I
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H
M
 
I
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L
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E
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G
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S
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D
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E
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Q
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K
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E
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L
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R
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E
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V
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S
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E
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A
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S
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L
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D
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A
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P
P
 
L
E
 
T
S
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S
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V
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x
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V
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I
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I
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T
E
 
E
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M
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A
K
 
K
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G
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H
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F
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G
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I
G
 
G
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G
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E
L
 
L
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A
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S
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K

5tigA Crystal structure of 4-oxalocrotonate tautomerase inactivated by brhpd (see paper)
41% identity, 97% coverage: 2:60/61 of query aligns to 1:59/62 of 5tigA

query
sites
5tigA
P
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P
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I
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A
H
 
Q
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I
Q
 
H
M
 
I
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L
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E
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G
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R
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S
D
 
D
E
 
E
Q
 
Q
K
 
K
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E
A
 
T
F
 
L
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I
R
 
R
E
 
E
A
 
V
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S
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E
A
 
A
A
 
I
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S
D
 
R
T
 
S
L
 
L
A
 
D
C
 
A
P
 
P
P
 
L
E
 
T
S
 
S
V
 
V
E
x
R
I
 
V
L
 
I
I
 
I
T
 
T
E
 
E
V
 
M
A
 
A
K
 
K
D
 
G
S
 
H
W
x
F
A
 
G
V
 
I
G
 
G
G
 
G
K
 
E
L
 
L
K
 
A
S
 
S
E
 
K

Sites not aligning to the query:

1bjpA Crystal structure of 4-oxalocrotonate tautomerase inactivated by 2- oxo-3-pentynoate at 2.4 angstroms resolution (see paper)
41% identity, 97% coverage: 2:60/61 of query aligns to 1:59/62 of 1bjpA

query
sites
1bjpA
P
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P
I
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I
L
 
A
H
 
Q
L
 
I
Q
 
H
M
 
I
H
 
L
P
 
E
G
 
G
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R
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S
D
 
D
E
 
E
Q
 
Q
K
 
K
R
 
E
A
 
T
F
 
L
V
 
I
R
 
R
E
 
E
A
 
V
T
 
S
R
 
E
A
 
A
A
 
I
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S
D
 
R
T
 
S
L
 
L
A
 
D
C
 
A
P
 
P
P
 
L
E
 
T
S
 
S
V
 
V
E
x
R
I
 
V
L
 
I
I
 
I
T
 
T
E
 
E
V
 
M
A
 
A
K
 
K
D
 
G
S
 
H
W
x
F
A
 
G
V
 
I
G
 
G
G
 
G
K
 
E
L
 
L
K
 
A
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S
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K

Sites not aligning to the query:

P70994 2-hydroxymuconate tautomerase; (2Z,4E)-2-hydroxyhexa-2,4-dienedioate keto-enol isomerase; 4-oxalocrotonate tautomerase; 4-OT; EC 5.3.2.6 from Bacillus subtilis (strain 168) (see paper)
43% identity, 92% coverage: 1:56/61 of query aligns to 1:56/62 of P70994

query
sites
P70994
M
 
M
P
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P
I
 
Y
L
 
V
H
 
T
L
 
V
Q
 
K
M
 
M
H
 
L
P
 
E
G
 
G
R
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R
T
 
T
D
 
D
E
 
E
Q
 
Q
K
 
K
R
 
R
A
 
N
F
 
L
V
 
V
R
 
E
E
 
K
A
 
V
T
 
T
R
 
E
A
 
A
A
 
V
V
 
K
D
 
E
T
 
T
L
 
T
A
 
G
C
 
A
P
 
S
P
 
E
E
 
E
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K
V
 
I
E
 
V
I
 
V
L
 
F
I
 
I
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E
E
 
E
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M
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R
K
 
K
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D
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H
W
 
Y
A
 
A
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V
G
 
A
G
 
G
K
 
K

6ghwC Substituting the prolines of 4-oxalocrotonate tautomerase with non- canonical analogue (2s)-3,4-dehydroproline (see paper)
41% identity, 92% coverage: 2:57/61 of query aligns to 1:56/57 of 6ghwC

query
sites
6ghwC
P
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P
I
 
I
L
 
A
H
 
Q
L
 
I
Q
 
H
M
 
I
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L
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E
G
 
G
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R
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S
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D
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E
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Q
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K
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E
A
 
T
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L
V
 
I
R
 
R
E
 
E
A
 
V
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S
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E
A
 
A
A
 
I
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S
D
x
R
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S
L
 
L
A
x
D
C
 
A
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P
P
 
L
E
 
T
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S
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V
E
x
R
I
 
V
L
 
I
I
 
I
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T
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E
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M
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A
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K
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G
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H
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F
A
 
G
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I
G
 
G
G
 
G
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E
L
 
L

2opaA Ywhb binary complex with 2-fluoro-p-hydroxycinnamate
42% identity, 90% coverage: 2:56/61 of query aligns to 1:55/61 of 2opaA

query
sites
2opaA
P
 
P
I
 
Y
L
 
V
H
 
T
L
 
V
Q
 
K
M
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M
H
 
L
P
 
E
G
 
G
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R
T
 
T
D
 
D
E
 
E
Q
 
Q
K
 
K
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R
A
 
N
F
 
L
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V
R
 
E
E
 
K
A
 
V
T
 
T
R
 
E
A
 
A
A
 
V
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K
D
 
E
T
 
T
L
 
T
A
 
G
C
 
A
P
 
S
P
 
E
E
 
E
S
 
K
V
 
I
E
x
V
I
 
V
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F
I
 
I
T
 
E
E
 
E
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M
A
 
R
K
 
K
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D
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H
W
x
Y
A
 
A
V
 
V
G
 
A
G
 
G
K
 
K

Sites not aligning to the query:

5cloM Crystal structure of a 4-oxalocrotonate tautomerase mutant in complex with nitrostyrene at 2.3 angstrom (see paper)
41% identity, 92% coverage: 2:57/61 of query aligns to 1:56/57 of 5cloM

query
sites
5cloM
P
|
P
I
 
I
L
 
A
H
 
Q
L
 
I
Q
 
H
M
 
I
H
 
L
P
 
E
G
 
G
R
 
R
T
 
S
D
 
D
E
 
E
Q
 
Q
K
 
K
R
 
E
A
 
T
F
 
L
V
 
I
R
 
R
E
 
E
A
 
V
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S
R
 
E
A
 
A
A
 
I
V
 
S
D
 
R
T
 
S
L
 
L
A
 
D
C
 
A
P
 
P
P
 
L
E
 
T
S
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S
V
 
V
E
x
R
I
 
V
L
 
I
I
 
I
T
 
T
E
 
E
V
 
Y
A
 
A
K
 
K
D
 
G
S
 
H
W
x
A
A
 
G
V
 
I
G
 
G
G
 
G
K
 
E
L
 
L

Query Sequence

>WP_011427992.1 NCBI__GCF_000092045.1:WP_011427992.1
MPILHLQMHPGRTDEQKRAFVREATRAAVDTLACPPESVEILITEVAKDSWAVGGKLKSE
G

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory