SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing WP_011504667.1 NCBI__GCF_900110435.1:WP_011504667.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

6s8nB Cryo-em structure of lptb2fgc in complex with lipopolysaccharide (see paper)
35% identity, 96% coverage: 7:235/239 of query aligns to 6:236/238 of 6s8nB

query
sites
6s8nB

K

K

G

N

V

L

S

A

K

K

R

A

F

Y

G

K

G

G

L

R

T

R

A

V

V

V

S

E

D

D

V

V

D

S

L

L

T

T

V

V

K

N

A

S

G

G

E

E

V

I

H

V

C

G

L

L

I

L

G

G

P

P

N

N

G

G

A

A

G

G

K

K

S

T

T

T

L

T

F

F

K

Y

L

M

I

V

V

V

G

G

L

I

F

V

P

P

P

R

T

D

S

A

G

G

S

N

I

I

L

I

F

I

D

D

S

D

A

D

D

D

I

I

T

S

A

L

E

L

R

P

P

L

Y

H

A

A

R

R

V

A

Q

R

R

R

G

G

M

I

S

G

I

Y

K

L

M

P

Q

Q

A

E

P

A

S

S

V

I

F

F

K
x
R

E

R

L

L

P

S

V

V

L

Y

Q

D

N

N

I

L

Q

M

I

A

A

V

L

L

Q

Q

E

I

R

R

-

D

C

L

S

S

G

A

A

E

E

Q

R

R

A

E

R

D

E

R

E

A

E

N

R

E

L

L

L

M

D

E

L

E

L

F

N

H

L

I

T

E

Q

H

D

L

R

R

D

D

K

S

M
|
M

A
x
G

G
x
Q

A

S

L

L

S

S

H

G

G

G

Q

E

Q

R

W

R

L

V

E

E

I

I

G

A

M

R

A

A

L

L

A

A

L

A

R

N

P

P

R

K

L

F

L

I

L

L

D

D

E

E

P

P

T

F

A

A

G

G

M

V

S

D

P

P

E

I

E

S

T

V

F

I

K

D

T

I

G

K

E

R

L

I

I

I

K

E

S

H

F

L

N

R

A

D

G

S

G

G

M

L

T

G

V

V

L

L

V

I

V

T

E

D

H

H

D

N

M

V

A

R

F

E

V

T

R

L

Q

A

I

V

A

C

Q

E

R

R

V

A

T

Y

V

I

L

V

H

S

L

Q

G

G

K

H

I

L

F

I

A

A

R

H

G

G

S

T

L

P

E

T

A

E

I

I

L

L

Q

Q

D

D

Q

E

Q

H

V

V

A

K

E

R

I

V

Y

Y

L

L

G

G

K

E

binding 2-decyl-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione: R90 (≠ K91), M133 (= M132), G134 (≠ A133), Q135 (≠ G134)

6s8gA Cryo-em structure of lptb2fgc in complex with amp-pnp (see paper)
35% identity, 96% coverage: 7:235/239 of query aligns to 6:236/238 of 6s8gA

query
sites
6s8gA

K

K

G

N

V

L

S

A

K

K

R

A

F
x
Y

G

K

G

G

L
x
R

T

R

A

V

V

V

S

E

D

D

V

V

D

S

L

L

T

T

V

V

K

N

A

S

G

G

E

E

V

I

H

V

C

G

L

L

I

L

G

G

P

P

N
|
N

G

G

A

A

G
|
G

K
|
K

S
x
T

T
|
T

L

T

F

F

K

Y

L

M

I

V

V

V

G

G

L

I

F

V

P

P

P

R

T

D

S

A

G

G

S

N

I

I

L

I

F

I

D

D

S

D

A

D

D

D

I

I

T

S

A

L

E

L

R

P

P

L

Y

H

A

A

R

R

V

A

Q

R

R

R

G

G

M

I

S

G

I

Y

K

L

M

P

Q
|
Q

A

E

P

A

S

S

V

I

F

F

K

R

E

R

L

L

P

S

V

V

L

Y

Q

D

N

N

I

L

Q

M

I

A

A

V

L

L

Q

Q

E

I

R

R

-

D

C

L

S

S

G

A

A

E

E

Q

R

R

A

E

R

D

E

R

E

A

E

N

R

E

L

L

L

M

D

E

L

E

L

F

N

H

L

I

T

E

Q

H

D

L

R

R

D

D

K

S

M

M

A

G

G

Q

A
x
S

L

L

S
|
S

H

G

G

G

Q
x
E

Q

R

W

R

L

V

E

E

I

I

G

A

M

R

A

A

L

L

A

A

L

A

R

N

P

P

R

K

L

F

L

I

L

L

D

D

E

E

P

P

T

F

A

A

G

G

M

V

S

D

P

P

E

I

E

S

T

V

F

I

K

D

T

I

G

K

E

R

L

I

I

I

K

E

S

H

F

L

N

R

A

D

G

S

G

G

M

L

T

G

V

V

L

L

V

I

V

T

E

D

H

H

D

N

M

V

A

R

F

E

V

T

R

L

Q

A

I

V

A

C

Q

E

R

R

V

A

T

Y

V

I

L

V

H

S

L

Q

G

G

K

H

I

L

F

I

A

A

R

H

G

G

S

T

L

P

E

T

A

E

I

I

L

L

Q

Q

D

D

Q

E

Q

H

V

V

A

K

E

R

I

V

Y

Y

L

L

G

G

K

E

binding phosphoaminophosphonic acid-adenylate ester: Y12 (≠ F13), R15 (≠ L16), N37 (= N38), G40 (= G41), K41 (= K42), T42 (≠ S43), T43 (= T44), Q84 (= Q85), S136 (≠ A135), S138 (= S137), E141 (≠ Q140)

6mhzA Vanadate trapped cryo-em structure of e.Coli lptb2fg transporter (see paper)
36% identity, 95% coverage: 7:234/239 of query aligns to 6:235/235 of 6mhzA

query
sites
6mhzA

K

K

G

N

V

L

S

A

K

K

R

A

F
x
Y

G

K

G

G

L

R

T

R

A

V

V

V

S

E

D

D

V

V

D

S

L

L

T

T

V

V

K

N

A

S

G

G

E

E

V

I

H

V

C

G

L

L

I

L

G

G

P

P

N
|
N

G
|
G

A

A

G
|
G

K
|
K

S
x
T

T
|
T

L

T

F

F

K

Y

L

M

I

V

V

V

G

G

L

I

F

V

P

P

P

R

T

D

S

A

G

G

S

N

I

I

L

I

F

I

D

D

S

D

A

D

D

D

I

I

T

S

A

L

E

L

R

P

P

L

Y

H

A

A

R

R

V

A

Q

R

R

R

G

G

M

I

S

G

I

Y

K

L

M

P

Q
|
Q

A

E

P

A

S

S

V

I

F

F

K

R

E

R

L

L

P

S

V

V

L

Y

Q

D

N

N

I

L

Q

M

I

A

A

V

L

L

Q

Q

E

I

R

R

-

D

C

L

S

S

G

A

A

E

E

Q

R

R

A

E

R

D

E

R

E

A

E

N

R

E

L

L

L

M

D

E

L

E

L

F

N

H

L

I

T

E

Q

H

D

L

R

R

D

D

K

S

M

M

A

G

G

Q

A
x
S

L

L

S
|
S

H
x
G

G
|
G

Q

E

Q

R

W

R

L

V

E

E

I

I

G

A

M

R

A

A

L

L

A

A

L

A

R

N

P

P

R

K

L

F

L

I

L

L

D

D

E
|
E

P

P

T

F

A

A

G
|
G

M

V

S

D

P

P

E

I

E

S

T

V

F

I

K

D

T

I

G

K

E

R

L

I

I

I

K

E

S

H

F

L

N

R

A

D

G

S

G

G

M

L

T

G

V

V

L

L

V

I

V

T

E

D

H
|
H

D

N

M

V

A

R

F

E

V

T

R

L

Q

A

I

V

A

C

Q

E

R

R

V

A

T

Y

V

I

L

V

H

S

L

Q

G

G

K

H

I

L

F

I

A

A

R

H

G

G

S

T

L

P

E

T

A

E

I

I

L

L

Q

Q

D

D

Q

E

Q

H

V

V

A

K

E

R

I

V

Y

Y

L

L

G

G

binding adp orthovanadate: Y12 (≠ F13), N37 (= N38), G38 (= G39), G40 (= G41), K41 (= K42), T42 (≠ S43), T43 (= T44), Q84 (= Q85), S136 (≠ A135), S138 (= S137), G139 (≠ H138), G140 (= G139), E162 (= E161), G166 (= G165), H194 (= H193)

6mbnA Lptb e163q in complex with atp (see paper)
35% identity, 96% coverage: 7:235/239 of query aligns to 7:237/241 of 6mbnA

query
sites
6mbnA

K

K

G

N

V

L

S

A

K

K

R

A

F
x
Y

G

K

G

G

L
x
R

T

R

A
x
V

V

V

S

E

D

D

V

V

D

S

L

L

T

T

V

V

K

N

A

S

G

G

E

E

V

I

H

V

C

G

L

L

I

L

G

G

P

P

N
|
N

G
|
G

A

A

G
|
G

K
|
K

S
x
T

T
|
T

L

T

F

F

K

Y

L

M

I

V

V

V

G

G

L

I

F

V

P

P

P

R

T

D

S

A

G

G

S

N

I

I

L

I

F

I

D

D

S

D

A

D

D

D

I

I

T

S

A

L

E

L

R

P

P

L

Y

H

A

A

R

R

V

A

Q

R

R

R

G

G

M

I

S

G

I

Y

K

L

M

P

Q

Q

A

E

P

A

S

S

V

I

F

F

K

R

E

R

L

L

P

S

V

V

L

Y

Q

D

N

N

I

L

Q

M

I

A

A

V

L

L

Q

Q

E

I

R

R

-

D

C

L

S

S

G

A

A

E

E

Q

R

R

A

E

R

D

E

R

E

A

E

N

R

E

L

L

L

M

D

E

L

E

L

F

N

H

L

I

T

E

Q

H

D

L

R

R

D

D

K

S

M

M

A

G

G

Q

A

S

L

L

S

S

H

G

G

G

Q

E

Q

R

W

R

L

V

E

E

I

I

G

A

M

R

A

A

L

L

A

A

L

A

R

N

P

P

R

K

L

F

L

I

L

L

D

D

E

Q

P

P

T

F

A

A

G

G

M

V

S

D

P

P

E

I

E

S

T

V

F

I

K

D

T

I

G

K

E

R

L

I

I

I

K

E

S

H

F

L

N

R

A

D

G

S

G

G

M

L

T

G

V

V

L

L

V

I

V

T

E

D

H
|
H

D

N

M

V

A

R

F

E

V

T

R

L

Q

A

I

V

A

C

Q

E

R

R

V

A

T

Y

V

I

L

V

H

S

L

Q

G

G

K

H

I

L

F

I

A

A

R

H

G

G

S

T

L

P

E

T

A

E

I

I

L

L

Q

Q

D

D

Q

E

Q

H

V

V

A

K

E

R

I

V

Y

Y

L

L

G

G

K

E

binding adenosine-5'-triphosphate: Y13 (≠ F13), R16 (≠ L16), V18 (≠ A18), N38 (= N38), G39 (= G39), G41 (= G41), K42 (= K42), T43 (≠ S43), T44 (= T44), H195 (= H193)

1g6hA Crystal structure of the adp conformation of mj1267, an atp-binding cassette of an abc transporter (see paper)
33% identity, 98% coverage: 1:235/239 of query aligns to 2:254/254 of 1g6hA

query
sites
1g6hA

M

M

S

E

L

I

V

L

E

R

V

T

K

E

G

N

V

I

S

V

K

K

R

Y

F
|
F

G

G

G

E

L
x
F

T

K

A

A

V

L

S

D

D

G

V

V

D

S

L

I

T

S

V

V

K

N

A

K

G

G

E

D

V

V

H

T

C

L

L

I

I

I

G

G

P

P

N
|
N

G
|
G

A

S

G
|
G

K
|
K

S
|
S

T
|
T

L

L

F

I

K

N

L

V

I

I

V

T

G

G

L

F

F

L

P

K

P

A

T

D

S

E

G

G

S

R

I

V

L

Y

F

F

D

E

S

N

A

K

D

D

I

I

T

T

A

N

E

K

R

E

P

P

Y

A

A

E

R

L

V

Y

Q

H

R

Y

G

G

M

I

S

V

I

R

K

T

M

F

Q

Q

A

T

P

P

S

Q

V

P

F

L

K

K

E

E

L

M

P

T

V

V

L

L

Q

E

N

N

I

L

Q

L

I

I

A

G

L

-

Q

-

E

E

R

I

C

C

S

P

G

G

A

E

E

S

R

P

-

L

-

N

-

S

-

L

-

F

-

Y

-

K

-

W

-

I

A

P

R

K

E

E

-

M

-

V

-

E

-

K

-

A

-

F

R

K

L

I

L

L

D

E

L

F

L

L

N

K

L

L

T

S

Q

H

D

L

R

Y

D

D

K

R

M

K

A

A

G

G

A

E

L

L

S

S

H

G

G

G

Q

Q

Q

M

Q

K

W

L

L

V

E

E

I

I

G

G

M

R

A

A

L

L

A

M

L

T

R

N

P

P

R

K

L

M

L

I

L

V

L

M

D

D

E

E

P

P

T

I

A

A

G

G

M

V

S

A

P

P

E

G

E

L

T

A

F

H

K

D

T

I

G

F

E

N

L

H

I

V

K

L

S

E

F

L

N

K

A

A

G

K

G

G

M

I

T

T

V

F

L

L

V

I

E

E

H

H

D

R

M

L

A

D

F

I

V

V

R

L

Q

N

I

Y

A

I

Q

D

R

H

V

L

T

Y

V

V

L

M

H

F

L

N

G

G

K

Q

I

I

F

I

A

A

R

E

G

G

-

R

-

G

-

E

S

E

L

I

E

K

A

N

I

V

L

L

Q

S

D

D

Q

P

Q

K

V

V

A

V

E

E

I

I

Y

Y

L

I

G

G

K

E

binding adenosine-5'-diphosphate: F14 (= F13), F17 (≠ L16), N39 (= N38), G40 (= G39), G42 (= G41), K43 (= K42), S44 (= S43), T45 (= T44)

6b89A E. Coli lptb in complex with adp and novobiocin (see paper)
35% identity, 95% coverage: 7:233/239 of query aligns to 6:234/234 of 6b89A

query
sites
6b89A

K

K

G

N

V

L

S

A

K

K

R

A

F
x
Y

G

K

G

G

L
x
R

T

R

A
x
V

V

V

S

E

D

D

V

V

D

S

L

L

T

T

V

V

K

N

A

S

G

G

E

E

V

I

H

V

C

G

L

L

I

L

G

G

P

P

N
|
N

G
|
G

A

A

G
|
G

K
|
K

S
x
T

T
|
T

L

T

F

F

K

Y

L

M

I

V

V

V

G

G

L

I

F

V

P

P

P

R

T

D

S

A

G

G

S

N

I

I

L

I

F

I

D

D

S

D

A

D

D

D

I

I

T

S

A

L

E

L

R

P

P
x
L

Y
x
H

A

A

R

R

V

A

Q

R

R

R

G

G

M

I

S

G

I

Y

K

L

M
x
P

Q
|
Q

A

E

P
x
A

S
|
S

V

I

F
|
F

K
x
R

E
x
R

L
|
L

P

S

V

V

L

Y

Q

D

N

N

I

L

Q

M

I

A

A
x
V

L

L

Q

Q

E

I

R

R

-

D

C

L

S

S

G

A

A

E

E

Q

R

R

A

E

R

D

E

R

E

A

E

N

R

E

L

L

L

M

D

E

L

E

L

F

N

H

L

I

T

E

Q

H

D

L

R

R

D

D

K

S

M

M

A

G

G
x
Q

A

S

L

L

S

S

H

G

G

G

Q

E

Q

R

W

R

L

V

E

E

I

I

G

A

M
x
R

A

A

L

L

A

A

L

A

R

N

P

P

R

K

L

F

L

I

L

L

D

D

E

E

P

P

T

F

A

A

G

G

M

V

S

D

P

P

E

I

E

S

T

V

F

I

K

D

T

I

G

K

E

R

L

I

I

I

K

E

S

H

F

L

N

R

A

D

G

S

G

G

M

L

T

G

V

V

L

L

V

I

V

T

E

D

H

H

D

N

M

V

A

R

F

E

V

T

R

L

Q

A

I

V

A

C

Q

E

R

R

V

A

T

Y

V

I

L

V

H

S

L

Q

G

G

K

H

I

L

F

I

A

A

R

H

G

G

S

T

L

P

E

T

A

E

I

I

L

L

Q

Q

D

D

Q

E

Q

H

V

V

A

K

E

R

I

V

Y

Y

L

L

binding adenosine-5'-diphosphate: Y12 (≠ F13), R15 (≠ L16), V17 (≠ A18), N37 (= N38), G38 (= G39), G40 (= G41), K41 (= K42), T42 (≠ S43), T43 (= T44)
binding magnesium ion: T42 (≠ S43), Q84 (= Q85)
binding novobiocin: L71 (≠ P72), H72 (≠ Y73), P83 (≠ M84), A86 (≠ P87), S87 (= S88), F89 (= F90), R90 (≠ K91), R91 (≠ E92), L92 (= L93), V101 (≠ A102), Q135 (≠ G134), R149 (≠ M148)

4p31A Crystal structure of a selenomethionine derivative of e. Coli lptb in complex with adp-magensium (see paper)
35% identity, 95% coverage: 7:233/239 of query aligns to 6:234/234 of 4p31A

query
sites
4p31A

K

K

G

N

V

L

S

A

K

K

R

A

F
x
Y

G

K

G

G

L
x
R

T

R

A
x
V

V

V

S

E

D

D

V

V

D

S

L

L

T

T

V

V

K

N

A

S

G

G

E

E

V

I

H

V

C

G

L

L

I

L

G

G

P

P

N

N

G
|
G

A

A

G
|
G

K
|
K

S
x
T

T
|
T

L

T

F

F

K

Y

L

M

I

V

V

V

G

G

L

I

F

V

P

P

P

R

T

D

S

A

G

G

S

N

I

I

L

I

F

I

D

D

S

D

A

D

D

D

I

I

T

S

A

L

E

L

R

P

P

L

Y

H

A

A

R

R

V

A

Q

R

R

R

G

G

M

I

S

G

I

Y

K

L

M

P

Q
|
Q

A

E

P

A

S

S

V

I

F

F

K

R

E

R

L

L

P

S

V

V

L

Y

Q

D

N

N

I

L

Q

M

I

A

A

V

L

L

Q

Q

E

I

R

R

-

D

C

L

S

S

G

A

A

E

E

Q

R

R

A

E

R

D

E

R

E

A

E

N

R

E

L

L

L

M

D

E

L

E

L

F

N

H

L

I

T

E

Q

H

D

L

R

R

D

D

K

S

M

M

A

G

G

Q

A

S

L

L

S

S

H

G

G

G

Q

E

Q

R

W

R

L

V

E

E

I

I

G

A

M

R

A

A

L

L

A

A

L

A

R

N

P

P

R

K

L

F

L

I

L

L

D

D

E

E

P

P

T

F

A

A

G

G

M

V

S

D

P

P

E

I

E

S

T

V

F

I

K

D

T

I

G

K

E

R

L

I

I

I

K

E

S

H

F

L

N

R

A

D

G

S

G

G

M

L

T

G

V

V

L

L

V

I

V

T

E

D

H

H

D

N

M

V

A

R

F

E

V

T

R

L

Q

A

I

V

A

C

Q

E

R

R

V

A

T

Y

V

I

L

V

H

S

L

Q

G

G

K

H

I

L

F

I

A

A

R

H

G

G

S

T

L

P

E

T

A

E

I

I

L

L

Q

Q

D

D

Q

E

Q

H

V

V

A

K

E

R

I

V

Y

Y

L

L

binding adenosine-5'-diphosphate: Y12 (≠ F13), R15 (≠ L16), V17 (≠ A18), G38 (= G39), G40 (= G41), K41 (= K42), T42 (≠ S43), T43 (= T44)
binding magnesium ion: T42 (≠ S43), Q84 (= Q85)

6b8bA E. Coli lptb in complex with adp and a novobiocin derivative (see paper)
35% identity, 95% coverage: 7:232/239 of query aligns to 6:233/233 of 6b8bA

query
sites
6b8bA

K

K

G

N

V

L

S

A

K

K

R

A

F
x
Y

G

K

G

G

L
x
R

T

R

A
x
V

V

V

S

E

D

D

V

V

D

S

L

L

T

T

V

V

K

N

A

S

G

G

E

E

V

I

H

V

C

G

L

L

I

L

G

G

P

P

N

N

G
|
G

A

A

G
|
G

K
|
K

S
x
T

T
|
T

L

T

F

F

K

Y

L

M

I

V

V

V

G

G

L

I

F

V

P

P

P

R

T

D

S

A

G

G

S

N

I

I

L

I

F

I

D

D

S

D

A

D

D

D

I

I

T

S

A

L

E

L

R

P

P

L

Y

H

A

A

R

R

V

A

Q

R

R

R

G

G

M

I

S

G

I

Y

K

L

M

P

Q

Q

A

E

P

A

S

S

V

I

F
|
F

K
x
R

E
x
R

L

L

P

S

V

V

L

Y

Q

D

N

N

I

L

Q

M

I

A

A

V

L

L

Q

Q

E

I

R

R

-

D

C

L

S

S

G

A

A

E

E

Q

R

R

A

E

R

D

E

R

E

A

E

N

R

E

L

L

L

M

D

E

L

E

L

F

N

H

L

I

T

E

Q

H

D

L

R

R

D

D

K

S

M

M

A

G

G

Q

A

S

L

L

S

S

H

G

G

G

Q

E

Q

R

W

R

L

V

E

E

I

I

G

A

M

R

A

A

L

L

A

A

L

A

R

N

P

P

R

K

L

F

L

I

L

L

D

D

E

E

P

P

T

F

A

A

G

G

M

V

S

D

P

P

E

I

E

S

T

V

F

I

K

D

T

I

G

K

E

R

L

I

I

I

K

E

S

H

F

L

N

R

A

D

G

S

G

G

M

L

T

G

V

V

L

L

V

I

V

T

E

D

H

H

D

N

M

V

A

R

F

E

V

T

R

L

Q

A

I

V

A

C

Q

E

R

R

V

A

T

Y

V

I

L

V

H

S

L

Q

G

G

K

H

I

L

F

I

A

A

R

H

G

G

S

T

L

P

E

T

A

E

I

I

L

L

Q

Q

D

D

Q

E

Q

H

V

V

A

K

E

R

I

V

Y

Y

binding adenosine-5'-diphosphate: Y12 (≠ F13), R15 (≠ L16), V17 (≠ A18), G38 (= G39), G40 (= G41), K41 (= K42), T42 (≠ S43), T43 (= T44)
binding (3s,5s,7s)-N-{7-[(3-O-carbamoyl-6-deoxy-5-methyl-4-O-methyl-beta-D-gulopyranosyl)oxy]-4-hydroxy-8-methyl-2-oxo-2H-1-benzopyran-3-yl}tricyclo[3.3.1.1~3,7~]decane-1-carboxamide: F89 (= F90), R90 (≠ K91), R91 (≠ E92)

1g9xB Characterization of the twinning structure of mj1267, an atp-binding cassette of an abc transporter (see paper)
32% identity, 98% coverage: 1:234/239 of query aligns to 2:253/253 of 1g9xB

query
sites
1g9xB

M

M

S

E

L

I

V

L

E

R

V

T

K

E

G

N

V

I

S

V

K

K

R

Y

F
|
F

G

G

G

E

L
x
F

T

K

A

A

V

L

S

D

D

G

V

V

D

S

L

I

T

S

V

V

K

C

A

K

G

G

E

D

V

V

H

T

C

L

L

I

I

I

G

G

P

P

N

N

G
|
G

A
x
S

G
|
G

K
|
K

S
|
S

T
|
T

L

L

F

I

K

N

L

V

I

I

V

T

G

G

L

F

F

L

P

K

P

A

T

D

S

E

G

G

S

R

I

V

L

Y

F

F

D

E

S

N

A

K

D

D

I

I

T

T

A

N

E

K

R

E

P

P

Y

A

A

E

R

L

V

Y

Q

H

R

Y

G

G

M

I

S

V

I

R

K

T

M

F

Q

Q

A

T

P

P

S

Q

V

P

F

L

K

K

E

E

L

M

P

T

V

V

L

L

Q

E

N

N

I

L

Q

L

I

I

A

G

-

E

-

I

-

N

-

P

-

G

-

E

-

S

-

P

L

L

Q

N

E

S

R

L

C

F

S

Y

G

K

A

K

E

W

R

I

A

P

R

K

E

E

-

M

-

V

-

E

-

K

-

A

-

F

R

K

L

I

L

L

D

E

L

F

L

L

N

K

L

L

T

S

Q

H

D

L

R

Y

D

D

K

R

M

K

A

A

G

G

A

E

L

L

S

S

H

G

G

G

Q

Q

Q

M

Q

K

W

L

L

V

E

E

I

I

G

G

M

R

A

A

L

L

A

M

L

T

R

N

P

P

R

K

L

M

L

I

L

V

L

M

D

D

E
|
E

P

P

T

I

A

A

G

G

M

V

S

A

P

P

E

G

E

L

T

A

F

H

K

D

T

I

G

F

E

N

L

H

I

V

K

L

S

E

F

L

N

K

A

A

G

K

G

G

M

I

T

T

V

F

L

L

V

I

E

E

H

H

D

R

M

L

A

D

F

I

V

V

R

L

Q

N

I

Y

A

I

Q

D

R

H

V

L

T

Y

V

V

L

M

H

F

L

N

G

G

K

Q

I

I

F

I

A

A

R

E

G

G

-

R

-

G

-

E

S

E

L

I

E

K

A

N

I

V

L

L

Q

S

D

D

Q

P

Q

K

V

V

A

V

E

E

I

I

Y

Y

L

I

G

G

binding adenosine-5'-diphosphate: F14 (= F13), F17 (≠ L16), G40 (= G39), S41 (≠ A40), G42 (= G41), K43 (= K42), S44 (= S43), T45 (= T44)
binding magnesium ion: S44 (= S43), E176 (= E161)

6mjpA Lptb(e163q)fgc from vibrio cholerae (see paper)
32% identity, 98% coverage: 2:235/239 of query aligns to 1:236/240 of 6mjpA

query
sites
6mjpA

S

A

L

I

V

L

E

K

V

A

K

Q

G

H

V

L

S

A

K

K

R

S

F

Y

G

K

L

R

T

K

A

V

V

V

S

S

D

D

V

V

D

S

L

L

T

Q

V

V

K

E

A

S

G

G

E

Q

V

I

H

V

C

G

L

L

I

L

G

G

P

P

N

N

G

G

A

A

G

G

K

K

S

T

T

T

L

S

F

F

K

Y

L

M

I

I

V

V

G

G

L

L

F

V

P

A

P

R

T

D

S

E

G

G

S

T

I

I

L

T

F

I

D

D

S

D

A

N

D

D

I

I

T

S

A

I

E

L

R

P

P

M

Y

H

A

S

R

R

V

S

Q

R

R

M

G

G

M

I

S

G

I

Y

K

L

M

P

Q

Q

A

E

P

A

S

S

V

I

F

F

K

R

E

K

L

L

P

S

V

V

L

E

Q

D

N

N

I

I

Q

M

I

A

A

V

L

L

Q

Q

-

T

-

R

E

E

R

E

C

L

S

T

G

H

A
x
E

E

E

R

R

A

Q

R
x
D

E

K

E

L

E

E

R

D

L

L

D

E

L

E

L

F

N

H

L

I

T

Q

Q

H

D

I

R

R

D

K

K

S

M

A

A

G

G

M

A

A

L

L

S

S

H

G

G

G

Q

E

Q

R

W

R

L

V

E

E

I

I

G

A

M

R

A

A

L

L

A

A

L

A

R

N

P

P

R

Q

L

F

L

I

L

L

D

D

E

Q

P

P

T

F

A

A

G

G

M

V

S

D

P

P

E

I

E

S

T

V

F

I

K

D

T

I

G

K

E

K

L

I

I

I

K

E

S

H

F

L

N

R

A

D

G

R

G

G

M

L

T

G

V

V

L

L

V

I

V

T

E

D

H

H

D

N

M

V

A

R

F

E

V

T

R

L

Q

D

I

V

A

C

Q

E

R

K

V

A

T

Y

V

I

L

V

H

S

L

Q

G

G

K

R

I

L

F

I

A

A

R

E

G

G

S

T

L

P

E

Q

A

D

I

V

L

L

Q

N

D

N

Q

E

Q

Q

V

V

A

K

E

Q

I

V

Y

Y

L

L

G

G

K

E

binding calcium ion: E111 (≠ A110), D115 (≠ R114)

1ji0A Crystal structure analysis of the abc transporter from thermotoga maritima
33% identity, 97% coverage: 3:234/239 of query aligns to 6:238/240 of 1ji0A

query
sites
1ji0A

L

V

V

L

E

E

V

V

K

Q

G

S

V

L

S

H

K

V

R

Y

F
x
Y

G

G

G

A

L

I

T

H

A

A

V

I

S

K

D

G

V

I

D

D

L

L

T

K

V

V

K

P

A

R

G

G

E

Q

V

I

H

V

C

T

L

L

I

I

G

G

P

A

N

N

G
|
G

A

A

G
|
G

K
|
K

S
x
T

T
|
T

L

T

F

L

K

S

L

A

I

I

V

A

G

G

L

L

F

V

P

R

P

A

T

Q

S

K

G

G

S

K

I

I

L

I

F

F

D

N

S

G

A

Q

D

D

I

I

T

T

A

N

E

K

R

P

P

A

Y

H

A

V

R

I

V

N

Q

R

R

M

G

G

M

I

S

A

I

L

K

V

M

P

Q
x
E

A

G

P

R

S

R

V

I

F

F

K

P

E

E

L

L

P

T

V

V

L

Y

Q

E

N

N

I

L

Q

M

I

M

A

G

L

A

Q

Y

E

N

R

R

C

K

S

D

G

K

A

E

E

G

R

I

A

K

R

R

E

D

E

L

E

E

R

W

L

I

L

F

D

S

L

L

L

F

N

P

L

R

T

L

Q

K

D

E

R

R

D

L

K

K

-

Q

M

L

A

G

G

G

A

T

L

L

S

S

H

G

G

G

Q

E

Q

Q

W

M

L

L

E

A

I

I

G

G

M

R

A

A

L

L

A

M

L

S

R

R

P

P

R

K

L

L

L

M

D

D

E
|
E

P

P

T

S

A

L

G

G

M

L

S

A

P

P

E

I

E

L

T

V

F

S

K

E

T

V

G

F

E

E

L

V

I

I

K

Q

S

K

F

I

N

N

A

Q

G

E

G

G

M

T

T

T

V

I

L

L

V

L

V

V

E

E

H

Q

D

N

M

A

A

L

F

G

V

A

R

L

Q

K

I

V

A

A

Q

H

R

Y

V

G

T

Y

V

V

L

L

H

E

L

T

G

G

K

Q

I

I

F

V

A

L

R

E

G

G

S

K

L

A

E

S

A

E

I

L

L

L

Q

D

D

N

Q

E

Q

M

V

V

A

R

E

K

I

A

Y

Y

L

L

G

G

binding adenosine-5'-triphosphate: Y16 (≠ F13), G42 (= G39), G44 (= G41), K45 (= K42), T46 (≠ S43), T47 (= T44), E88 (≠ Q85), E165 (= E161)

4u00A Crystal structure of ttha1159 in complex with adp (see paper)
33% identity, 92% coverage: 3:223/239 of query aligns to 2:224/241 of 4u00A

query
sites
4u00A

L

I

V

I

E

R

V

I

K

R

G

N

V

L

S

H

K

K

R

W

F
|
F

G

G

G

P

L

L

T

H

A
x
V

V

L

S

K

D

G

V

I

D

H

L

L

T

E

V

V

K

A

A

P

G

G

E

E

V

K

H

L

C

V

L

I

I

I

G

G

P

P

N
x
S

G
|
G

A
x
S

G
|
G

K
|
K

S
|
S

T
|
T

L

L

F

I

K

R

L

T

I

I

V

N

G

R

L

L

F

E

P

D

P

F

T

Q

S

E

G

G

S

E

I

V

L

V

F

V

D

D

S

G

A

L

D

S

I

V

T

K

A

D

E

D

R

R

P

A

Y

L

A

R

R

E

V

I

Q

R

R

R

G

E

M

V

S

G

I

M

K

V

M

F

Q

Q

A

Q

P

F

S

N

V

L

F

F

K

P

E

H

L

M

P

T

V

V

L

L

Q

E

N

N

I

V

Q

T

I

L

A

A

L

P

Q

M

E

-

R

R

C

V

S

R

G

R

A

W

E

P

R

R

A

E

R

K

E

A

E

E

E

K

R

K

L

A

L

L

D

E

L

L

N

E

-

R

-

V

-

G

-

I

L

L

T

D

Q

Q

D

A

R

R

D

-

K

K

M

Y

A

P

G

A

A

Q

L

L

S

S

H

G

G

G

Q

Q

W

R

L

V

E

A

I

I

G

A

M

R

A

A

L

L

A

A

L

M

R

E

P

P

R

K

L

I

L

M

L

L

L

F

D

D

E

E

P

P

T

T

A

S

G

A

M

L

S

D

P

P

E

E

E

M

T

V

F

G

K

E

T

V

G

L

E

D

L

V

I

M

K

R

S

D

F

L

N

A

A

Q

G

G

M

M

T

T

V

M

L

V

V

V

E

T

H

H

D

E

M

M

A

G

F

F

V

A

R

R

Q

E

I

V

A

A

Q

D

R

R

V

V

T

V

V

F

L

M

H

D

L

G

G

G

K

Q

I

I

F

V

A

E

R

E

G

G

S

R

L

P

E

E

A

E

I

I

L

F

binding adenosine-5'-diphosphate: F12 (= F13), V17 (≠ A18), S37 (≠ N38), G38 (= G39), S39 (≠ A40), G40 (= G41), K41 (= K42), S42 (= S43), T43 (= T44)

4ymuJ Crystal structure of an amino acid abc transporter complex with arginines and atps (see paper)
34% identity, 92% coverage: 3:223/239 of query aligns to 1:224/240 of 4ymuJ

query
sites
4ymuJ

L

M

V

I

E

F

V

V

K

N

G

D

V

V

S

Y

K

K

R

N

F
|
F

G

G

G

S

L

L

T

E

A
x
V

V

L

S

K

D

G

V

V

D

T

L

L

T

K

V

V

K

N

A

K

G

G

E

E

V

V

H

V

C

V

L

I

I

I

G

G

P

P

N
x
S

G
|
G

A
x
S

G
|
G

K
|
K

S
|
S

T
|
T

L

L

F

L

K

R

L

C

I

I

V

N

G

L

L

L

F

E

P

E

P

P

T

T

S

K

G

G

S

E

I

V

L

F

F

I

D

D

S

G

A

V

D

K

I

I

T

N

A

N

E

G

R

K

-

V

P

N

Y

I

A

N

R

K

V

V

Q

R

R

Q

G

K

M

V

S

G

I

M

K

V

M

F

Q

Q

A

H

P

F

S

N

V

L

F

F

K

P

E

H

L

L

P

T

V

A

L

I

Q

E

N

N

I

I

Q

T

I

L

A

A

L

-

Q

P

E

V

R

K

C

V

S

K

G

K

A

M

E

N

R

K

A

K

R

E

E

A

E

E

R

L

L

A

L

V

D

D

L

L

-

A

-

K

-

V

N

G

L

L

T

L

Q

D

D

K

R

K

D

D

K

Q

M

Y

A

P

G

I

A

K

L

L

S

S

H

G

G

G

Q

Q

Q

K

Q

Q

W

R

L

L

E

A

I

I

G

A

M

R

A

A

L

L

A

A

L

M

R

Q

P

P

R

E

L

V

L

M

L

L

L

F

D

D

E
|
E

P

P

T

T

A

S

G

A

M

L

S

D

P

P

E

E

E

M

T

V

F

K

K

E

T

V

G

L

E

N

L

V

I

M

K

K

S

Q

F

L

N

A

A

N

G

E

G

G

M

M

T

T

V

M

L

V

V

V

E

T

H
|
H

D

E

M

M

A

G

F

F

V

A

R

R

Q

E

I

V

A

G

Q

D

R

R

V

V

T

I

V

F

L

M

H

D

L

D

G

G

K

V

I

I

F

V

A

E

R

E

G

G

S

T

L

P

E

E

A

E

I

I

L

F

binding adenosine-5'-triphosphate: F11 (= F13), V16 (≠ A18), S36 (≠ N38), G37 (= G39), S38 (≠ A40), G39 (= G41), K40 (= K42), S41 (= S43), T42 (= T44), E162 (= E161), H194 (= H193)
binding magnesium ion: S41 (= S43), E162 (= E161)

P04983 Ribose import ATP-binding protein RbsA; EC 7.5.2.7 from Escherichia coli (strain K12) (see paper)
29% identity, 98% coverage: 2:235/239 of query aligns to 3:240/501 of P04983

query
sites
P04983

S

A

L

L

V

L

E

Q

V

L

K

K

G

G

V

I

S

D

K

K

R

A

F

F

G

P

G

G

L

V

T

K

A

A

V

L

S

S

D

G

V

A

D

A

L

L

T

N

V

V

K

Y

A

P

G

G

E

R

V

V

H

M

C

A

L

L

I

V

G

G

P

E

N

N

G

G

A

A

G

G

K
|
K

S

S

T

T

L

M

F

M

K

K

L

V

I

L

V

T

G

G

L

I

F

Y

P

T

P

R

T

D

S

A

G

G

S

T

I

L

L

L

F

W

D

L

S

G

A

K

D

E

I

T

T

T

A

F

E

T

R

G

P

P

Y

K

A

S

R

S

V

Q

Q

E

R

A

G

G

M

I

S

G

I

I

K

I

M

H

Q

Q

A

E

P

L

S

N

V

L

F

I

K

P

E

Q

L

L

P

T

V

I

L

A

Q

E

N

N

I

I

Q

F

I

L

A

G

L

R

Q

E

-

F

-

V

-

N

-

R

-

F

E

G

R

K

C

I

S

D

G

W

A

K

E

T

R

M

A

Y

R

A

E

E

E

A

E

D

R

K

L

L

D

A

L

K

L

L

N

N

L

L

T

R

Q

F

D

K

R

S

D

D

K

K

M

L

A

V

G

G

A

D

L

L

S

S

H

I

G

G

Q

D

Q

Q

W

M

L

V

E

E

I

I

G

A

M

K

A

V

L

L

A

S

L

F

R

E

P

S

R

K

L

V

L

I

L

M

D

D

E

E

P

P

T

T

A

D

G

A

M

L

S

T

P

D

E

T

E

E

T

T

F

E

K

S

T

L

G

F

E

R

L

V

I

I

K

R

S

E

F

L

N

K

A

S

G

Q

G

G

M

R

T

G

V

I

L

V

V

Y

V

I

E

S

H

H

D

R

M

M

A

K

F

E

V

I

R

F

Q

E

I

I

A

C

Q

D

R

D

V

V

T

T

V

V

L

F

H

R

L

D

G

G

K

Q

I

F

F

I

A

A

R

E

G

R

S

E

L

V

E

A

A

S

I

L

L

T

Q

E

D

D

Q

S

Q

L

V

I

A

-

E

E

I

M

Y

M

L

V

G

G

K

R

K43 (= K42) mutation to R: Loss of transport.

3c4jA Abc protein artp in complex with atp-gamma-s
30% identity, 95% coverage: 1:227/239 of query aligns to 1:230/242 of 3c4jA

query
sites
3c4jA

M

L

S

Q

L

M

V

I

E

D

V

V

K

H

G

Q

V

L

S

K

K

K

R

S

F
|
F

G

G

G

S

L

L

T

E

A
x
V

V

L

S

K

D

G

V

I

D

N

L

V

T

H

V

I

K

R

A

E

G

G

E

E

V

V

H

V

C

V

L

V

I

I

G

G

P

P

N
x
S

G
|
G

A
x
S

G
|
G

K
|
K

S
|
S

T
|
T

L

F

F

L

K

R

L

C

I

L

V

N

G

L

L

L

F

E

P

D

P

F

T

D

S

E

G

G

S

E

I

I

L

I

F

I

D

D

S

G

A

I

D

N

I

L

T

K

A

A

-

K

E

D

R

T

P

N

Y

L

A

N

R

K

V

V

Q

R

R

E

G

E

M

V

S

G

I

M

K

V

M

F

Q

Q

A

R

P

F

S

N

V

L

F

F

K

P

E

H

L

M

P

T

V

V

L

L

Q

N

N

N

I

I

Q

T

I

L

A

A

L

P

Q

M

E

-

R

K

C

V

S

R

G

K

A

W

E

P

R

R

A

E

R

K

E

A

E

E

E

A

R

K

L

A

L

M

D

E

L

L

N

D

L

K

T

V

Q

G

D

L

R

K

D

D

K

K

-

A

-

H

-

A

M

Y

A

P

G

D

A

S

L

L

S

S

H

G

G

G

Q

Q

Q

A

Q

Q

W

R

L

V

E

A

I

I

G

A

M

R

A

A

L

L

A

A

L

M

R

E

P

P

R

K

L

I

L

M

L

L

L

F

D

D

E

E

P

P

T

T

A

S

G

A

M

L

S

D

P

P

E

E

E

M

T

V

F

G

K

E

T

V

G

L

E

S

L

V

I

M

K

K

S

Q

F

L

N

A

A

N

G

E

G

G

M

M

T

T

V

M

L

V

V

V

E

T

H

H

D

E

M

M

A

G

F

F

V

A

R

R

Q

E

I

V

A

G

Q

D

R

R

V

V

T

L

V

F

L

M

H

D

L

G

G

G

K

Y

I

I

F

I

A

E

R

E

G

G

S

K

L

P

E

E

A

D

I

L

L

F

Q

D

D

R

Q

P

Q

Q

binding phosphothiophosphoric acid-adenylate ester: F13 (= F13), V18 (≠ A18), S38 (≠ N38), G39 (= G39), S40 (≠ A40), G41 (= G41), K42 (= K42), S43 (= S43), T44 (= T44)

3c41J Abc protein artp in complex with amp-pnp/mg2+
30% identity, 95% coverage: 1:227/239 of query aligns to 1:230/242 of 3c41J

query
sites
3c41J

M

L

S

Q

L

M

V

I

E

D

V

V

K

H

G

Q

V

L

S

K

K

K

R

S

F
|
F

G

G

G

S

L

L

T

E

A
x
V

V

L

S

K

D

G

V

I

D

N

L

V

T

H

V

I

K

R

A

E

G

G

E

E

V

V

H

V

C

V

L

V

I

I

G

G

P

P

N
x
S

G
|
G

A

S

G
|
G

K
|
K

S
|
S

T
|
T

L

F

F

L

K

R

L

C

I

L

V

N

G

L

L

L

F

E

P

D

P

F

T

D

S

E

G

G

S

E

I

I

L

I

F

I

D

D

S

G

A

I

D

N

I

L

T

K

A

A

-

K

E

D

R

T

P

N

Y

L

A

N

R

K

V

V

Q

R

R

E

G

E

M

V

S

G

I

M

K

V

M

F

Q

Q

A

R

P

F

S

N

V

L

F

F

K

P

E

H

L

M

P

T

V

V

L

L

Q

N

N

N

I

I

Q

T

I

L

A

A

L

P

Q

M

E

-

R

K

C

V

S

R

G

K

A

W

E

P

R

R

A

E

R

K

E

A

E

E

E

A

R

K

L

A

L

M

D

E

L

L

N

D

L

K

T

V

Q

G

D

L

R

K

D

D

K

K

-

A

-

H

-

A

M

Y

A

P

G

D

A

S

L

L

S

S

H

G

G

G

Q

Q

Q

A

Q

Q

W

R

L

V

E

A

I

I

G

A

M

R

A

A

L

L

A

A

L

M

R

E

P

P

R

K

L

I

L

M

L

L

L

F

D
|
D

E

E

P

P

T

T

A

S

G

A

M

L

S

D

P

P

E

E

E

M

T

V

F

G

K

E

T

V

G

L

E

S

L

V

I

M

K

K

S

Q

F

L

N

A

A

N

G

E

G

G

M

M

T

T

V

M

L

V

V

V

E

T

H

H

D

E

M

M

A

G

F

F

V

A

R

R

Q

E

I

V

A

G

Q

D

R

R

V

V

T

L

V

F

L

M

H

D

L

G

G

G

K

Y

I

I

F

I

A

E

R

E

G

G

S

K

L

P

E

E

A

D

I

L

L

F

Q

D

D

R

Q

P

Q

Q

binding phosphoaminophosphonic acid-adenylate ester: F13 (= F13), V18 (≠ A18), S38 (≠ N38), G39 (= G39), G41 (= G41), K42 (= K42), S43 (= S43), T44 (= T44)
binding magnesium ion: S43 (= S43), D163 (= D160)

2olkA Abc protein artp in complex with adp-beta-s
30% identity, 95% coverage: 1:227/239 of query aligns to 1:230/242 of 2olkA

query
sites
2olkA

M

L

S

Q

L

M

V

I

E

D

V

V

K

H

G

Q

V

L

S

K

K

K

R

S

F
|
F

G

G

G

S

L

L

T

E

A
x
V

V

L

S

K

D

G

V

I

D

N

L

V

T

H

V

I

K

R

A

E

G

G

E

E

V

V

H

V

C

V

L

V

I

I

G

G

P

P

N
x
S

G
|
G

A
x
S

G
|
G

K
|
K

S
|
S

T
|
T

L

F

F

L

K

R

L

C

I

L

V

N

G

L

L

L

F

E

P

D

P

F

T

D

S

E

G

G

S

E

I

I

L

I

F

I

D

D

S

G

A

I

D

N

I

L

T

K

A

A

-

K

E

D

R

T

P

N

Y

L

A

N

R

K

V

V

Q

R

R

E

G

E

M

V

S

G

I

M

K

V

M

F

Q

Q

A

R

P

F

S

N

V

L

F

F

K

P

E

H

L

M

P

T

V

V

L

L

Q

N

N

N

I

I

Q

T

I

L

A

A

L

P

Q

M

E

-

R

K

C

V

S

R

G

K

A

W

E

P

R

R

A

E

R

K

E

A

E

E

E

A

R

K

L

A

L

M

D

E

L

L

N

D

L

K

T

V

Q

G

D

L

R

K

D

D

K

K

-

A

-

H

-

A

M

Y

A

P

G

D

A

S

L

L

S

S

H

G

G

G

Q

Q

Q

A

Q

Q

W

R

L

V

E

A

I

I

G

A

M

R

A

A

L

L

A

A

L

M

R

E

P

P

R

K

L

I

L

M

L

L

L

F

D

D

E

E

P

P

T

T

A

S

G

A

M

L

S

D

P

P

E

E

E

M

T

V

F

G

K

E

T

V

G

L

E

S

L

V

I

M

K

K

S

Q

F

L

N

A

A

N

G

E

G

G

M

M

T

T

V

M

L

V

V

V

E

T

H

H

D

E

M

M

A

G

F

F

V

A

R

R

Q

E

I

V

A

G

Q

D

R

R

V

V

T

L

V

F

L

M

H

D

L

G

G

G

K

Y

I

I

F

I

A

E

R

E

G

G

S

K

L

P

E

E

A

D

I

L

L

F

Q

D

D

R

Q

P

Q

Q

binding 5'-o-[(r)-hydroxy(thiophosphonooxy)phosphoryl]adenosine: F13 (= F13), V18 (≠ A18), S38 (≠ N38), G39 (= G39), S40 (≠ A40), G41 (= G41), K42 (= K42), S43 (= S43), T44 (= T44)

2oljA Abc protein artp in complex with adp/mg2+
30% identity, 95% coverage: 1:227/239 of query aligns to 1:230/242 of 2oljA

query
sites
2oljA

M

L

S

Q

L

M

V

I

E

D

V

V

K

H

G

Q

V

L

S

K

K

K

R

S

F
|
F

G

G

G

S

L

L

T

E

A
x
V

V

L

S

K

D

G

V

I

D

N

L

V

T

H

V

I

K

R

A

E

G

G

E

E

V

V

H

V

C

V

L

V

I

I

G

G

P

P

N
x
S

G
|
G

A
x
S

G
|
G

K
|
K

S
|
S

T
|
T

L

F

F

L

K

R

L

C

I

L

V

N

G

L

L

L

F

E

P

D

P

F

T

D

S

E

G

G

S

E

I

I

L

I

F

I

D

D

S

G

A

I

D

N

I

L

T

K

A

A

-

K

E

D

R

T

P

N

Y

L

A

N

R

K

V

V

Q

R

R

E

G

E

M

V

S

G

I

M

K

V

M

F

Q

Q

A

R

P

F

S

N

V

L

F

F

K

P

E

H

L

M

P

T

V

V

L

L

Q

N

N

N

I

I

Q

T

I

L

A

A

L

P

Q

M

E

-

R

K

C

V

S

R

G

K

A

W

E

P

R

R

A

E

R

K

E

A

E

E

E

A

R

K

L

A

L

M

D

E

L

L

N

D

L

K

T

V

Q

G

D

L

R

K

D

D

K

K

-

A

-

H

-

A

M

Y

A

P

G

D

A

S

L

L

S

S

H

G

G

G

Q

Q

Q

A

Q

Q

W

R

L

V

E

A

I

I

G

A

M

R

A

A

L

L

A

A

L

M

R

E

P

P

R

K

L

I

L

M

L

L

L

F

D

D

E

E

P

P

T

T

A

S

G

A

M

L

S

D

P

P

E

E

E

M

T

V

F

G

K

E

T

V

G

L

E

S

L

V

I

M

K

K

S

Q

F

L

N

A

A

N

G

E

G

G

M

M

T

T

V

M

L

V

V

V

E

T

H

H

D

E

M

M

A

G

F

F

V

A

R

R

Q

E

I

V

A

G

Q

D

R

R

V

V

T

L

V

F

L

M

H

D

L

G

G

G

K

Y

I

I

F

I

A

E

R

E

G

G

S

K

L

P

E

E

A

D

I

L

L

F

Q

D

D

R

Q

P

Q

Q

binding adenosine-5'-diphosphate: F13 (= F13), V18 (≠ A18), S38 (≠ N38), G39 (= G39), S40 (≠ A40), G41 (= G41), K42 (= K42), S43 (= S43), T44 (= T44)

5x40A Structure of a cbio dimer bound with amppcp (see paper)
34% identity, 89% coverage: 14:226/239 of query aligns to 16:231/280 of 5x40A

query
sites
5x40A

G

G

L
x
V

T

K

A
|
A

V

L

S

D

D

D

V

L

D

S

L

L

T

A

V

V

K

P

A

K

G

G

E

E

V

S

H

L

C

A

L

I

I

L

G

G

P

P

N
|
N

G
|
G

A

A

G
|
G

K
|
K

S
|
S

T
|
T

L

L

F

L

K

L

L

H

I

L

V

N

G

G

L

T

F

L

P

R

P

P

T

Q

S

S

G

G

S

R

I

V

L

L

F

L

D

G

S

G

A

T

-

A

-

T

-

G

-

H

-

S

-

R

-

K

D

D

I

L

T

T

A

G

-

W

E

R

R

R

P

R

Y

V

A

G

R

L

V

V

Q

L

R
x
Q

G

D

M

A

S

D

I

D

K

Q

M

L

Q

F

A

A

P

T

S

T

V

V

F

F

K

E

E

D

L

V

P

S

V

-

L

F

Q

G

N

P

I

L

Q

N

I

L

A

G

L

L

Q

S

E

E

R

-

C

-

S

-

G

A

A

E

E

A

R

R

A

A

R

R

E

V

E

E

R

A

L

L

L

A

D

A

L

L

L

-

N

S

L

I

T

S

Q

D

D

L

R

R

D

D

K

R

M

P

A

T

G
x
H

A
x
M

L
|
L

S
|
S

H

G

G
|
G

Q
|
Q

Q

K

Q

R

W

R

L

V

E

A

I

I

G

A

M

G

A

A

L

V

A

A

L

M

R

R

P

P

R

E

L

V

L

L

D

D

E
x
Q

P

P

T

T

A

A

G

G

M

L

S

D

P

L

E

A

E

G

T

T

F

E

K

Q

T

L

G

L

E

T

L

L

I

L

K

R

S

G

F

L

N

R

A

A

G

A

G

G

M

M

T

T

V

L

L

V

V

F

V

S

E

T

H
|
H

D

D

M

V

A

E

F

L

V

A

R

A

Q

A

I

L

A

A

Q

D

R

R

V

V

T

A

V

L

L

F

H

R

L

T

G

G

K

R

I

V

F

L

A

A

R

E

G

G