SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing WP_011601970.1 NCBI__GCF_000058485.1:WP_011601970.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

1ji0A Crystal structure analysis of the abc transporter from thermotoga maritima
56% identity, 87% coverage: 1:232/267 of query aligns to 5:238/240 of 1ji0A

query
sites
1ji0A

M

I

L

V

L

L

T

E

L

V

S

Q

D

S

V

L

E

H

V

V

A

Y

Y
|
Y

G

G

A

A

V

I

T

H

A

A

L

I

R

K

G

G

V

I

S

D

L

L

E

K

V

V

A

P

E

R

G

G

E

Q

I

I

V

V

T

T

L

L

L

I

G

G

A

A

N

N

G
|
G

A

A

G
|
G

K
|
K

T
|
T

T
|
T

T

T

L

L

R

S

T

A

I

I

S

A

G

G

L

L

L

V

R

R

P

A

K

Q

A

K

G

G

E

K

V

I

R

I

L

F

D

N

G

G

R

Q

P

D

L

I

S

T

S

N

I

K

P

P

A

A

H

H

G

V

L

I

V

N

G

R

A

M

G

G

V

I

S

A

H

L

V

V

P

P

E
|
E

G

G

R

R

R

R

V

I

F

F

P

P

S

E

M

L

S

T

V

V

R

Y

E

E

N

N

L

L

L

M

M

M

G

G

A

A

Y

Y

H

N

-

R

-

K

D

D

R

K

R

E

H

G

A

I

R

K

A

R

D

D

L

L

E

E

R

W

V

I

V

F

A

S

L

L

F

F

P

P

R

R

L

L

A

K

E

E

R

R

I

L

G

K

Q

Q

A

L

G

G

G

G

T

T

L

L

S

S

G

G

G

G

E

E

Q

Q

Q

Q

M

M

L

L

A

A

I

I

G

G

R

R

A

A

L

L

M

M

S

S

R

R

P

P

R

K

L

L

I

L

L

M

L

M

D

D

E
|
E

P

P

S

S

M

L

G

G

L

L

A

A

P

P

M

I

I

L

V

V

Q

S

T

E

I

V

F

F

E

E

V

V

I

I

A

Q

E

K

I

I

N

N

R

Q

E

E

G

G

V

T

A

T

V

I

L

L

L

L

V

V

E

E

Q

Q

N

N

A

A

A

L

S

G

A

A

L

L

R

K

I

V

A

A

G

H

R

Y

G

G

Y

Y

V

V

L

L

E

E

T

T

G

G

R

Q

V

I

V

V

L

L

A

E

D

G

T

K

A

A

A

S

A

E

L

L

L

L

A

D

D

N

D

E

R

M

V

V

R

R

Q

K

A

A

Y

Y

L

L

G

G

binding adenosine-5'-triphosphate: Y16 (= Y12), G42 (= G38), G44 (= G40), K45 (= K41), T46 (= T42), T47 (= T43), E88 (= E84), E165 (= E159)

6mjpA Lptb(e163q)fgc from vibrio cholerae (see paper)
33% identity, 84% coverage: 11:233/267 of query aligns to 11:236/240 of 6mjpA

query
sites
6mjpA

A

S

Y

Y

G

K

A

K

V

R

T

K

A

V

L

V

R

S

G

D

V

V

S

S

L

L

E

Q

V

V

A

E

E

S

G

G

E

Q

I

I

V

V

T

G

L

L

L

L

G

G

A

P

N

N

G

G

A

A

G

G

K

K

T

T

T

T

T

S

L

F

R

Y

T

M

I

I

S

V

G

G

L

L

L

V

R

A

P

R

K

D

A

E

G

G

E

T

V

I

R

T

L

I

D

D

G

D

R

N

P

D

L

I

S

S

S

I

I

L

P

P

A

M

H

H

G

S

L

R

V

S

G

R

A

M

G

G

V

I

S

G

H

Y

V

L

P

P

E

Q

G

E

R

A

R

S

V

I

F

F

P

R

S

K

M

L

S

S

V

V

R

E

E

D

N

N

L

I

L

M

M

A

-

V

-

L

-

Q

-

T

-

R

-

E

G

E

A

L

Y

T

H

H

D
x
E

R

E

R

R

H

Q

A
x
D

R

K

A

-

D

-

L

L

E

E

R

D

V

L

V

L

A

E

L

E

F

F

P

-

R

H

L

I

A

Q

E

H

R

I

I

R

G

K

Q

S

A

A

G

G

G

M

T

A

L

L

S

S

G

G

G

G

E

E

Q

R

Q

R

M

R

L

V

A

E

I

I

G

A

R

R

A

A

L

L

M

A

S

A

R

N

P

P

R

Q

L

F

I

I

L

L

L

L

D

D

E

Q

P

P

S

F

M

A

G

G

L

V

A

D

P

P

M

I

I

S

V

V

Q

I

T

D

I

I

F

K

E

K

V

I

I

I

A

E

E

H

I

L

N

R

R

D

E

R

G

G

V

L

A

G

V

V

L

L

L

I

V

T

E

D

Q

H

N

N

A

V

A

R

S

E

A

T

L

L

R

D

I

V

A

C

G

E

R

K

G

A

Y

Y

V

I

L

V

E

S

T

Q

G

G

R

R

V

L

V

I

L

A

A

E

D

G

T

T

A

P

A

Q

A

D

L

V

L

L

A

N

D

N

D

E

R

Q

V

V

R

K

Q

Q

A

V

Y

Y

L

L

G

G

E

E

binding calcium ion: E111 (≠ D105), D115 (≠ A109)

6s8nB Cryo-em structure of lptb2fgc in complex with lipopolysaccharide (see paper)
34% identity, 87% coverage: 3:235/267 of query aligns to 3:238/238 of 6s8nB

query
sites
6s8nB

L

L

T

T

L

A

S

K

D

N

V

L

E

A

V

K

A

A

Y

Y

G

K

A

G

V

R

T

R

A

V

L

V

R

E

G

D

V

V

S

S

L

L

E

T

V

V

A

N

E

S

G

G

E

E

I

I

V

V

T

G

L

L

L

L

G

G

A

P

N

N

G

G

A

A

G

G

K

K

T

T

T

T

T

T

L

F

R

Y

T

M

I

V

S

V

G

G

L

I

L

V

R

P

P

R

K

D

A

A

G

G

E

N

V

I

R

I

L

I

D

D

G

D

R

D

P

D

L

I

S

S

S

L

I

L

P

P

A

L

H

H

G

A

L

R

V

A

G

R

A

R

G

G

V

I

S

G

H

Y

V

L

P

P

E

Q

G

E

R

A

R

S

V

I

F

F

P
x
R

S

R

M

L

S

S

V

V

R

Y

E

D

N

N

L

L

L

M

M

A

-

V

-

L

-

Q

-

I

-

R

-

D

G

D

A

L

Y

S

H

A

D

E

R

Q

R

R

H

E

A

D

R

R

A

A

D

N

L

E

E

L

R

M

V

E

V

E

A

F

L

H

F

I

P

E

R

H

L

L

A

R

E

D

R

S

I
x
M

G
|
G

Q
|
Q

A

-

G

-

G

-

T

S

L

L

S

S

G

G

G

G

E

E

Q

R

Q

R

M

R

L

V

A

E

I

I

G

A

R

R

A

A

L

L

M

A

S

A

R

N

P

P

R

K

L

F

I

I

L

L

L

L

D

D

E

E

P

P

S

F

M

A

G

G

L

V

A

D

P

P

M

I

I

S

V

V

Q

I

T

D

I

I

F

K

E

R

V

I

I

I

A

E

E

H

I

L

N

R

R

D

E

S

G

G

V

L

A

G

V

V

L

L

L

I

V

T

E

D

Q

H

N

N

A

V

A

R

S

E

A

T

L

L

R

A

I

V

A

C

G

E

R

R

G

A

Y

Y

V

I

L

V

E

S

T

Q

G

G

R

H

V

L

V

I

L

A

A

H

D

G

T

T

A

P

A

T

A

E

L

I

L

L

A

Q

D

D

D

E

R

H

V

V

R

K

Q

R

A

V

Y

Y

L

L

G

G

E

E

D

D

V

F

binding 2-decyl-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione: R90 (≠ P90), M133 (≠ I127), G134 (= G128), Q135 (= Q129)

6s8gA Cryo-em structure of lptb2fgc in complex with amp-pnp (see paper)
34% identity, 87% coverage: 3:235/267 of query aligns to 3:238/238 of 6s8gA

query
sites
6s8gA

L

L

T

T

L

A

S

K

D

N

V

L

E

A

V

K

A

A

Y
|
Y

G

K

A

G

V
x
R

T

R

A

V

L

V

R

E

G

D

V

V

S

S

L

L

E

T

V

V

A

N

E

S

G

G

E

E

I

I

V

V

T

G

L

L

L

L

G

G

A

P

N
|
N

G

G

A

A

G
|
G

K
|
K

T
|
T

T
|
T

T

T

L

F

R

Y

T

M

I

V

S

V

G

G

L

I

L

V

R

P

P

R

K

D

A

A

G

G

E

N

V

I

R

I

L

I

D

D

G

D

R

D

P

D

L

I

S

S

S

L

I

L

P

P

A

L

H

H

G

A

L

R

V

A

G

R

A

R

G

G

V

I

S

G

H

Y

V

L

P

P

E
x
Q

G

E

R

A

R

S

V

I

F

F

P

R

S

R

M

L

S

S

V

V

R

Y

E

D

N

N

L

L

L

M

M

A

-

V

-

L

-

Q

-

I

-

R

-

D

G

D

A

L

Y

S

H

A

D

E

R

Q

R

R

H

E

A

D

R

R

A

A

D

N

L

E

E

L

R

M

V

E

V

E

A

F

L

H

F

I

P

E

R

H

L

L

A

R

E

D

R

S

I

M

G

G

Q

Q

A

-

G

-

G

-

T
x
S

L

L

S
|
S

G

G

G

G

E
|
E

Q

R

Q

R

M

R

L

V

A

E

I

I

G

A

R

R

A

A

L

L

M

A

S

A

R

N

P

P

R

K

L

F

I

I

L

L

L

L

D

D

E

E

P

P

S

F

M

A

G

G

L

V

A

D

P

P

M

I

I

S

V

V

Q

I

T

D

I

I

F

K

E

R

V

I

I

I

A

E

E

H

I

L

N

R

R

D

E

S

G

G

V

L

A

G

V

V

L

L

L

I

V

T

E

D

Q

H

N

N

A

V

A

R

S

E

A

T

L

L

R

A

I

V

A

C

G

E

R

R

G

A

Y

Y

V

I

L

V

E

S

T

Q

G

G

R

H

V

L

V

I

L

A

A

H

D

G

T

T

A

P

A

T

A

E

L

I

L

L

A

Q

D

D

D

E

R

H

V

V

R

K

Q

R

A

V

Y

Y

L

L

G

G

E

E

D

D

V

F

binding phosphoaminophosphonic acid-adenylate ester: Y12 (= Y12), R15 (≠ V15), N37 (= N37), G40 (= G40), K41 (= K41), T42 (= T42), T43 (= T43), Q84 (≠ E84), S136 (≠ T133), S138 (= S135), E141 (= E138)

6mbnA Lptb e163q in complex with atp (see paper)
33% identity, 87% coverage: 3:235/267 of query aligns to 4:239/241 of 6mbnA

query
sites
6mbnA

L

L

T

T

L

A

S

K

D

N

V

L

E

A

V

K

A

A

Y
|
Y

G

K

A

G

V
x
R

T

R

A
x
V

L

V

R

E

G

D

V

V

S

S

L

L

E

T

V

V

A

N

E

S

G

G

E

E

I

I

V

V

T

G

L

L

L

L

G

G

A

P

N
|
N

G
|
G

A

A

G
|
G

K
|
K

T
|
T

T
|
T

T

T

L

F

R

Y

T

M

I

V

S

V

G

G

L

I

L

V

R

P

P

R

K

D

A

A

G

G

E

N

V

I

R

I

L

I

D

D

G

D

R

D

P

D

L

I

S

S

S

L

I

L

P

P

A

L

H

H

G

A

L

R

V

A

G

R

A

R

G

G

V

I

S

G

H

Y

V

L

P

P

E

Q

G

E

R

A

R

S

V

I

F

F

P

R

S

R

M

L

S

S

V

V

R

Y

E

D

N

N

L

L

L

M

M

A

-

V

-

L

-

Q

-

I

-

R

-

D

G

D

A

L

Y

S

H

A

D

E

R

Q

R

R

H

E

A

D

R

R

A

A

D

N

L

E

E

L

R

M

V

E

V

E

A

F

L

H

F

I

P

E

R

H

L

L

A

R

E

D

R

S

I

M

G

G

Q

Q

A

-

G

-

G

-

T

S

L

L

S

S

G

G

G

G

E

E

Q

R

Q

R

M

R

L

V

A

E

I

I

G

A

R

R

A

A

L

L

M

A

S

A

R

N

P

P

R

K

L

F

I

I

L

L

L

L

D

D

E

Q

P

P

S

F

M

A

G

G

L

V

A

D

P

P

M

I

I

S

V

V

Q

I

T

D

I

I

F

K

E

R

V

I

I

I

A

E

E

H

I

L

N

R

R

D

E

S

G

G

V

L

A

G

V

V

L

L

L

I

V

T

E

D

Q
x
H

N

N

A

V

A

R

S

E

A

T

L

L

R

A

I

V

A

C

G

E

R

R

G

A

Y

Y

V

I

L

V

E

S

T

Q

G

G

R

H

V

L

V

I

L

A

A

H

D

G

T

T

A

P

A

T

A

E

L

I

L

L

A

Q

D

D

D

E

R

H

V

V

R

K

Q

R

A

V

Y

Y

L

L

G

G

E

E

D

D

V

F

binding adenosine-5'-triphosphate: Y13 (= Y12), R16 (≠ V15), V18 (≠ A17), N38 (= N37), G39 (= G38), G41 (= G40), K42 (= K41), T43 (= T42), T44 (= T43), H195 (≠ Q191)

6mhzA Vanadate trapped cryo-em structure of e.Coli lptb2fg transporter (see paper)
33% identity, 86% coverage: 3:232/267 of query aligns to 3:235/235 of 6mhzA

query
sites
6mhzA

L

L

T

T

L

A

S

K

D

N

V

L

E

A

V

K

A

A

Y
|
Y

G

K

A

G

V

R

T

R

A

V

L

V

R

E

G

D

V

V

S

S

L

L

E

T

V

V

A

N

E

S

G

G

E

E

I

I

V

V

T

G

L

L

L

L

G

G

A

P

N
|
N

G
|
G

A

A

G
|
G

K
|
K

T
|
T

T
|
T

T

T

L

F

R

Y

T

M

I

V

S

V

G

G

L

I

L

V

R

P

P

R

K

D

A

A

G

G

E

N

V

I

R

I

L

I

D

D

G

D

R

D

P

D

L

I

S

S

S

L

I

L

P

P

A

L

H

H

G

A

L

R

V

A

G

R

A

R

G

G

V

I

S

G

H

Y

V

L

P

P

E
x
Q

G

E

R

A

R

S

V

I

F

F

P

R

S

R

M

L

S

S

V

V

R

Y

E

D

N

N

L

L

L

M

M

A

-

V

-

L

-

Q

-

I

-

R

-

D

G

D

A

L

Y

S

H

A

D

E

R

Q

R

R

H

E

A

D

R

R

A

A

D

N

L

E

E

L

R

M

V

E

V

E

A

F

L

H

F

I

P

E

R

H

L

L

A

R

E

D

R

S

I

M

G

G

Q

Q

A

-

G

-

G

-

T
x
S

L

L

S
|
S

G
|
G

G
|
G

E

E

Q

R

Q

R

M

R

L

V

A

E

I

I

G

A

R

R

A

A

L

L

M

A

S

A

R

N

P

P

R

K

L

F

I

I

L

L

L

L

D

D

E
|
E

P

P

S

F

M

A

G
|
G

L

V

A

D

P

P

M

I

I

S

V

V

Q

I

T

D

I

I

F

K

E

R

V

I

I

I

A

E

E

H

I

L

N

R

R

D

E

S

G

G

V

L

A

G

V

V

L

L

L

I

V

T

E

D

Q
x
H

N

N

A

V

A

R

S

E

A

T

L

L

R

A

I

V

A

C

G

E

R

R

G

A

Y

Y

V

I

L

V

E

S

T

Q

G

G

R

H

V

L

V

I

L

A

A

H

D

G

T

T

A

P

A

T

A

E

L

I

L

L

A

Q

D

D

D

E

R

H

V

V

R

K

Q

R

A

V

Y

Y

L

L

G

G

binding adp orthovanadate: Y12 (= Y12), N37 (= N37), G38 (= G38), G40 (= G40), K41 (= K41), T42 (= T42), T43 (= T43), Q84 (≠ E84), S136 (≠ T133), S138 (= S135), G139 (= G136), G140 (= G137), E162 (= E159), G166 (= G163), H194 (≠ Q191)

6b89A E. Coli lptb in complex with adp and novobiocin (see paper)
33% identity, 86% coverage: 3:231/267 of query aligns to 3:234/234 of 6b89A

query
sites
6b89A

L

L

T

T

L

A

S

K

D

N

V

L

E

A

V

K

A

A

Y
|
Y

G

K

A

G

V
x
R

T

R

A
x
V

L

V

R

E

G

D

V

V

S

S

L

L

E

T

V

V

A

N

E

S

G

G

E

E

I

I

V

V

T

G

L

L

L

L

G

G

A

P

N
|
N

G
|
G

A

A

G
|
G

K
|
K

T
|
T

T
|
T

T

T

L

F

R

Y

T

M

I

V

S

V

G

G

L

I

L

V

R

P

P

R

K

D

A

A

G

G

E

N

V

I

R

I

L

I

D

D

G

D

R

D

P

D

L

I

S

S

S

L

I

L

P

P

A
x
L

H
|
H

G

A

L

R

V

A

G

R

A

R

G

G

V

I

S

G

H

Y

V

L

P
|
P

E
x
Q

G

E

R
x
A

R
x
S

V

I

F
|
F

P
x
R

S
x
R

M
x
L

S

S

V

V

R

Y

E

D

N

N

L

L

L

M

M

A

-
x
V

-

L

-

Q

-

I

-

R

-

D

G

D

A

L

Y

S

H

A

D

E

R

Q

R

R

H

E

A

D

R

R

A

A

D

N

L

E

E

L

R

M

V

E

V

E

A

F

L

H

F

I

P

E

R

H

L

L

A

R

E

D

R

S

I

M

G

G

Q
|
Q

A

-

G

-

G

-

T

S

L

L

S

S

G

G

G

G

E

E

Q

R

Q

R

M

R

L

V

A

E

I

I

G

A

R
|
R

A

A

L

L

M

A

S

A

R

N

P

P

R

K

L

F

I

I

L

L

L

L

D

D

E

E

P

P

S

F

M

A

G

G

L

V

A

D

P

P

M

I

I

S

V

V

Q

I

T

D

I

I

F

K

E

R

V

I

I

I

A

E

E

H

I

L

N

R

R

D

E

S

G

G

V

L

A

G

V

V

L

L

L

I

V

T

E

D

Q

H

N

N

A

V

A

R

S

E

A

T

L

L

R

A

I

V

A

C

G

E

R

R

G

A

Y

Y

V

I

L

V

E

S

T

Q

G

G

R

H

V

L

V

I

L

A

A

H

D

G

T

T

A

P

A

T

A

E

L

I

L

L

A

Q

D

D

D

E

R

H

V

V

R

K

Q

R

A

V

Y

Y

L

L

binding adenosine-5'-diphosphate: Y12 (= Y12), R15 (≠ V15), V17 (≠ A17), N37 (= N37), G38 (= G38), G40 (= G40), K41 (= K41), T42 (= T42), T43 (= T43)
binding magnesium ion: T42 (= T42), Q84 (≠ E84)
binding novobiocin: L71 (≠ A71), H72 (= H72), P83 (= P83), A86 (≠ R86), S87 (≠ R87), F89 (= F89), R90 (≠ P90), R91 (≠ S91), L92 (≠ M92), V101 (vs. gap), Q135 (= Q129), R149 (= R146)

4p31A Crystal structure of a selenomethionine derivative of e. Coli lptb in complex with adp-magensium (see paper)
33% identity, 86% coverage: 3:231/267 of query aligns to 3:234/234 of 4p31A

query
sites
4p31A

L

L

T

T

L

A

S

K

D

N

V

L

E

A

V

K

A

A

Y
|
Y

G

K

A

G

V
x
R

T

R

A
x
V

L

V

R

E

G

D

V

V

S

S

L

L

E

T

V

V

A

N

E

S

G

G

E

E

I

I

V

V

T

G

L

L

L

L

G

G

A

P

N

N

G
|
G

A

A

G
|
G

K
|
K

T
|
T

T
|
T

T

T

L

F

R

Y

T

M

I

V

S

V

G

G

L

I

L

V

R

P

P

R

K

D

A

A

G

G

E

N

V

I

R

I

L

I

D

D

G

D

R

D

P

D

L

I

S

S

S

L

I

L

P

P

A

L

H

H

G

A

L

R

V

A

G

R

A

R

G

G

V

I

S

G

H

Y

V

L

P

P

E
x
Q

G

E

R

A

R

S

V

I

F

F

P

R

S

R

M

L

S

S

V

V

R

Y

E

D

N

N

L

L

L

M

M

A

-

V

-

L

-

Q

-

I

-

R

-

D

G

D

A

L

Y

S

H

A

D

E

R

Q

R

R

H

E

A

D

R

R

A

A

D

N

L

E

E

L

R

M

V

E

V

E

A

F

L

H

F

I

P

E

R

H

L

L

A

R

E

D

R

S

I

M

G

G

Q

Q

A

-

G

-

G

-

T

S

L

L

S

S

G

G

G

G

E

E

Q

R

Q

R

M

R

L

V

A

E

I

I

G

A

R

R

A

A

L

L

M

A

S

A

R

N

P

P

R

K

L

F

I

I

L

L

L

L

D

D

E

E

P

P

S

F

M

A

G

G

L

V

A

D

P

P

M

I

I

S

V

V

Q

I

T

D

I

I

F

K

E

R

V

I

I

I

A

E

E

H

I

L

N

R

R

D

E

S

G

G

V

L

A

G

V

V

L

L

L

I

V

T

E

D

Q

H

N

N

A

V

A

R

S

E

A

T

L

L

R

A

I

V

A

C

G

E

R

R

G

A

Y

Y

V

I

L

V

E

S

T

Q

G

G

R

H

V

L

V

I

L

A

A

H

D

G

T

T

A

P

A

T

A

E

L

I

L

L

A

Q

D

D

D

E

R

H

V

V

R

K

Q

R

A

V

Y

Y

L

L

binding adenosine-5'-diphosphate: Y12 (= Y12), R15 (≠ V15), V17 (≠ A17), G38 (= G38), G40 (= G40), K41 (= K41), T42 (= T42), T43 (= T43)
binding magnesium ion: T42 (= T42), Q84 (≠ E84)

1g6hA Crystal structure of the adp conformation of mj1267, an atp-binding cassette of an abc transporter (see paper)
27% identity, 87% coverage: 2:233/267 of query aligns to 4:254/254 of 1g6hA

query
sites
1g6hA

L

I

L

L

T

R

L

T

S

E

D

N

V

I

E

V

V

K

A

Y

Y
x
F

G

G

A

E

V
x
F

T

K

A

A

L

L

R

D

G

G

V

V

S

S

L

I

E

S

V

V

A

N

E

K

G

G

E

D

I

V

V

T

T

L

L

I

L

I

G

G

A

P

N
|
N

G
|
G

A

S

G
|
G

K
|
K

T
x
S

T
|
T

T

L

L

I

R

N

T

V

I

I

S

T

G

G

L

F

L

L

R

K

P

A

K

D

A

E

G

G

E

R

V

V

R

Y

L

F

D

E

G

N

R

K

P

D

L

I

S

T

S

N

I

K

P

E

A

P

H

A

G

E

L

L

V

Y

G

H

A

Y

G

G

V

I

S

V

H

R

V

T

P

F

E

Q

G

T

R

P

R

Q

V

P

F

L

P

K

S

E

M

M

S

T

V

V

R

L

E

E

N

N

L

L

L

L

M

I

G

G

A

E

-

I

-

C

-

P

-

G

-

E

-

S

-

P

-

L

-

N

-

S

-

L

Y

F

H

Y

D

K

R

K

R

W

H

I

A

P

R

K

A

E

D

E

-

E

-

M

L

V

E

E

R

K

V

A

V

F

A

K

L

I

-

L

-

E

F

F

P

L

R

K

L

L

A

S

E

H

R

L

I

Y

G

D

Q

R

A

K

G

A

G

G

T

E

L

L

S

S

G

G

G

G

E

Q

Q

M

Q

K

M

L

L

V

A

E

I

I

G

G

R

R

A

A

L

L

M

M

S

T

R

N

P

P

R

K

L

M

I

I

L

V

L

M

D

D

E

E

P

P

S

I

M

A

G

G

L

V

A

A

P

P

M

G

I

L

V

A

Q

H

T

D

I

I

F

F

E

N

V

H

I

V

A

L

E

E

I

L

N

K

R

A

E

K

G

G

V

I

A

T

V

F

L

L

L

I

V

I

E

E

Q

H

N

R

A

L

A

D

S

I

A

V

L

L

R

N

I

Y

A

I

G

D

R

H

G

L

Y

Y

V

V

L

M

E

F

T

N

G

G

R

Q

V

I

V

I

L

A

-

E

-

G

-

R

-

G

A

E

D

E

T

E

A

I

A

K

A

N

L

V

L

L

A

S

D

D

D

P

R

K

V

V

R

V

Q

E

A

I

Y

Y

L

I

G

G

E

E

binding adenosine-5'-diphosphate: F14 (≠ Y12), F17 (≠ V15), N39 (= N37), G40 (= G38), G42 (= G40), K43 (= K41), S44 (≠ T42), T45 (= T43)

6b8bA E. Coli lptb in complex with adp and a novobiocin derivative (see paper)
33% identity, 85% coverage: 3:230/267 of query aligns to 3:233/233 of 6b8bA

query
sites
6b8bA

L

L

T

T

L

A

S

K

D

N

V

L

E

A

V

K

A

A

Y
|
Y

G

K

A

G

V
x
R

T

R

A
x
V

L

V

R

E

G

D

V

V

S

S

L

L

E

T

V

V

A

N

E

S

G

G

E

E

I

I

V

V

T

G

L

L

L

L

G

G

A

P

N

N

G
|
G

A

A

G
|
G

K
|
K

T
|
T

T
|
T

T

T

L

F

R

Y

T

M

I

V

S

V

G

G

L

I

L

V

R

P

P

R

K

D

A

A

G

G

E

N

V

I

R

I

L

I

D

D

G

D

R

D

P

D

L

I

S

S

S

L

I

L

P

P

A

L

H

H

G

A

L

R

V

A

G

R

A

R

G

G

V

I

S

G

H

Y

V

L

P

P

E

Q

G

E

R

A

R

S

V

I

F
|
F

P
x
R

S
x
R

M

L

S

S

V

V

R

Y

E

D

N

N

L

L

L

M

M

A

-

V

-

L

-

Q

-

I

-

R

-

D

G

D

A

L

Y

S

H

A

D

E

R

Q

R

R

H

E

A

D

R

R

A

A

D

N

L

E

E

L

R

M

V

E

V

E

A

F

L

H

F

I

P

E

R

H

L

L

A

R

E

D

R

S

I

M

G

G

Q

Q

A

-

G

-

G

-

T

S

L

L

S

S

G

G

G

G

E

E

Q

R

Q

R

M

R

L

V

A

E

I

I

G

A

R

R

A

A

L

L

M

A

S

A

R

N

P

P

R

K

L

F

I

I

L

L

L

L

D

D

E

E

P

P

S

F

M

A

G

G

L

V

A

D

P

P

M

I

I

S

V

V

Q

I

T

D

I

I

F

K

E

R

V

I

I

I

A

E

E

H

I

L

N

R

R

D

E

S

G

G

V

L

A

G

V

V

L

L

L

I

V

T

E

D

Q

H

N

N

A

V

A

R

S

E

A

T

L

L

R

A

I

V

A

C

G

E

R

R

G

A

Y

Y

V

I

L

V

E

S

T

Q

G

G

R

H

V

L

V

I

L

A

A

H

D

G

T

T

A

P

A

T

A

E

L

I

L

L

A

Q

D

D

D

E

R

H

V

V

R

K

Q

R

A

V

Y

Y

binding adenosine-5'-diphosphate: Y12 (= Y12), R15 (≠ V15), V17 (≠ A17), G38 (= G38), G40 (= G40), K41 (= K41), T42 (= T42), T43 (= T43)
binding (3s,5s,7s)-N-{7-[(3-O-carbamoyl-6-deoxy-5-methyl-4-O-methyl-beta-D-gulopyranosyl)oxy]-4-hydroxy-8-methyl-2-oxo-2H-1-benzopyran-3-yl}tricyclo[3.3.1.1~3,7~]decane-1-carboxamide: F89 (= F89), R90 (≠ P90), R91 (≠ S91)

1g9xB Characterization of the twinning structure of mj1267, an atp-binding cassette of an abc transporter (see paper)
26% identity, 87% coverage: 2:232/267 of query aligns to 4:253/253 of 1g9xB

query
sites
1g9xB

L

I

L

L

T

R

L

T

S

E

D

N

V

I

E

V

V

K

A

Y

Y
x
F

G

G

A

E

V
x
F

T

K

A

A

L

L

R

D

G

G

V

V

S

S

L

I

E

S

V

V

A

C

E

K

G

G

E

D

I

V

V

T

T

L

L

I

L

I

G

G

A

P

N

N

G
|
G

A
x
S

G
|
G

K
|
K

T
x
S

T
|
T

T

L

L

I

R

N

T

V

I

I

S

T

G

G

L

F

L

L

R

K

P

A

K

D

A

E

G

G

E

R

V

V

R

Y

L

F

D

E

G

N

R

K

P

D

L

I

S

T

S

N

I

K

P

E

A

P

H

A

G

E

L

L

V

Y

G

H

A

Y

G

G

V

I

S

V

H

R

V

T

P

F

E

Q

G

T

R

P

R

Q

V

P

F

L

P

K

S

E

M

M

S

T

V

V

R

L

E

E

N

N

L

L

L

L

M

I

G

G

A

E

-

I

-

N

-

P

-

G

-

E

-

S

-

P

-

L

-

N

-

S

-

L

Y

F

H

Y

D

K

R

K

R

W

H

I

A

P

R

K

A

E

D

E

-

E

-

M

L

V

E

E

R

K

V

A

V

F

A

K

L

I

-

L

-

E

F

F

P

L

R

K

L

L

A

S

E

H

R

L

I

Y

G

D

Q

R

A

K

G

A

G

G

T

E

L

L

S

S

G

G

G

G

E

Q

Q

M

Q

K

M

L

L

V

A

E

I

I

G

G

R

R

A

A

L

L

M

M

S

T

R

N

P

P

R

K

L

M

I

I

L

V

L

M

D

D

E
|
E

P

P

S

I

M

A

G

G

L

V

A

A

P

P

M

G

I

L

V

A

Q

H

T

D

I

I

F

F

E

N

V

H

I

V

A

L

E

E

I

L

N

K

R

A

E

K

G

G

V

I

A

T

V

F

L

L

L

I

V

I

E

E

Q

H

N

R

A

L

A

D

S

I

A

V

L

L

R

N

I

Y

A

I

G

D

R

H

G

L

Y

Y

V

V

L

M

E

F

T

N

G

G

R

Q

V

I

V

I

L

A

-

E

-

G

-

R

-

G

A

E

D

E

T

E

A

I

A

K

A

N

L

V

L

L

A

S

D

D

D

P

R

K

V

V

R

V

Q

E

A

I

Y

Y

L

I

G

G

binding adenosine-5'-diphosphate: F14 (≠ Y12), F17 (≠ V15), G40 (= G38), S41 (≠ A39), G42 (= G40), K43 (= K41), S44 (≠ T42), T45 (= T43)
binding magnesium ion: S44 (≠ T42), E176 (= E159)

4ymuJ Crystal structure of an amino acid abc transporter complex with arginines and atps (see paper)
29% identity, 85% coverage: 2:228/267 of query aligns to 1:234/240 of 4ymuJ

query
sites
4ymuJ

L

M

L

I

T

F

L

V

S

N

D

D

V

V

E

Y

V

K

A

N

Y
x
F

G

G

A

S

V

L

T

E

A
x
V

L

L

R

K

G

G

V

V

S

T

L

L

E

K

V

V

A

N

E

K

G

G

E

E

I

V

V

V

T

V

L

I

L

I

G

G

A

P

N
x
S

G
|
G

A
x
S

G
|
G

K
|
K

T
x
S

T
|
T

T

L

L

L

R

R

T

C

I

I

S

N

G

L

L

L

L

E

R

E

P

P

K

T

A

K

G

G

E

E

V

V

R

F

L

I

D

D

G

G

R

V

P

K

L

I

S

N

S

N

I

G

P

K

A

V

H

N

-

I

G

N

L

K

V

V

G

R

A

Q

G

K

V

V

S

G

H

M

V

V

P

F

E

Q

G

H

R

F

R

N

V

L

F

F

P

P

S

H

M

L

S

T

V

A

R

I

E

E

N

N

L

I

L

T

M

L

G

A

A

P

Y

V

H

K

D

V

R

K

R

K

H

M

A

N

R

K

A

K

D

E

L

A

E

E

R

E

V

L

-

A

V

V

A

D

L

L

F

L

P

A

R

K

-

V

-

G

L

L

A

L

E

D

R

K

I

K

G

D

Q

Q

A

Y

G

P

G

I

T

K

L

L

S

S

G

G

G

G

E

Q

Q

K

Q

Q

M

R

L

L

A

A

I

I

G

A

R

R

A

A

L

L

M

A

S

M

R

Q

P

P

R

E

L

V

I

M

L

L

L

F

D

D

E
|
E

P

P

S

T

M

S

G

A

L

L

A

D

P

P

M

E

I

M

V

V

Q

K

T

E

I

V

F

L

E

N

V

V

I

M

A

K

E

Q

I

L

N

A

R

N

E

E

G

G

V

M

A

T

V

M

L

V

L

V

V

V

E

T

Q
x
H

N

E

A

M

A

G

S

F

A

A

L

R

R

E

I

V

A

G

G

D

R

R

G

V

Y

I

V

F

L

M

E

D

T

D

G

G

R

V

V

I

V

V

L

E

A

E

D

G

T

T

A

P

A

E

A

E

L

I

L

F

-

Y

-

R

-

A

A

K

D

N

D

E

R

R

V

T

R

R

Q

E

binding adenosine-5'-triphosphate: F11 (≠ Y12), V16 (≠ A17), S36 (≠ N37), G37 (= G38), S38 (≠ A39), G39 (= G40), K40 (= K41), S41 (≠ T42), T42 (= T43), E162 (= E159), H194 (≠ Q191)
binding magnesium ion: S41 (≠ T42), E162 (= E159)

4u00A Crystal structure of ttha1159 in complex with adp (see paper)
31% identity, 79% coverage: 2:212/267 of query aligns to 2:215/241 of 4u00A

query
sites
4u00A

L

I

L

I

T

R

L

I

S

R

D

N

V

L

E

H

V

K

A

W

Y
x
F

G

G

A

P

V

L

T

H

A
x
V

L

L

R

K

G

G

V

I

S

H

L

L

E

E

V

V

A

A

E

P

G

G

E

E

I

K

V

L

T

V

L

I

L

I

G

G

A

P

N
x
S

G
|
G

A
x
S

G
|
G

K
|
K

T
x
S

T
|
T

T

L

L

I

R

R

T

T

I

I

S

N

G

R

L

L

L

E

R

D

P

F

K

Q

A

E

G

G

E

E

V

V

R

V

L

V

D

D

G

G

R

L

P

S

L

V

S

K

S

D

I

D

P

R

A

A

H

L

G

R

L

E

V

I

G

R

A

R

G

E

V

V

S

G

H

M

V

V

P

F

E

Q

G

Q

R

F

R

N

V

L

F

F

P

P

S

H

M

M

S

T

V

V

R

L

E

E

N

N

L

V

L

T

M

L

G

A

A

P

Y

M

H

R

D

V

R

R

R

R

H

W

A

P

R

R

A

E

D

K

L

A

E

E

R

K

V

K

V

A

A

L

L

-

F

-

P

-

R

E

L

L

A

L

E

E

R

R

I

V

G

G

-

I

-

L

-

D

-

Q

-

A

-

R

Q

K

A

Y

G

P

G

A

T

Q

L

L

S

S

G

G

G

G

E

Q

Q

Q

Q

Q

M

R

L

V

A

A

I

I

G

A

R

R

A

A

L

L

M

A

S

M

R

E

P

P

R

K

L

I

I

M

L

L

L

F

D

D

E

E

P

P

S

T

M

S

G

A

L

L

A

D

P

P

M

E

I

M

V

V

Q

G

T

E

I

V

F

L

E

D

V

V

I

M

A

R

E

D

I

L

N

A

R

Q

E

G

G

G

V

M

A

T

V

M

L

V

L

V

V

V

E

T

Q

H

N

E

A

M

A

G

S

F

A

A

L

R

R

E

I

V

A

A

G

D

R

R

G

V

Y

V

V

F

L

M

E

D

T

G

G

G

R

Q

V

I

V

V

binding adenosine-5'-diphosphate: F12 (≠ Y12), V17 (≠ A17), S37 (≠ N37), G38 (= G38), S39 (≠ A39), G40 (= G40), K41 (= K41), S42 (≠ T42), T43 (= T43)

7zdkC If(apo/asym) conformation of cyddc in amp-pnp(cydc)/amp-pnp(cydd) bound state (dataset-8) (see paper)
35% identity, 82% coverage: 3:222/267 of query aligns to 339:561/573 of 7zdkC

query
sites
7zdkC

L

L

T

T

L

L

S

R

D

D

V

V

E

Q

V

F

A

T

Y
|
Y

-

P

-

E

G
x
Q

A

S

V

Q

T

Q

A

A

L

L

R

K

G

G

V

I

S

S

L

L

E

Q

V

V

A

N

E

A

G

G

E

E

I

H

V

I

T

A

L

I

L

L

G

G

A

R

N

T

G
|
G

A
x
C

G
|
G

K
|
K

T
x
S

T
|
T

T

L

L

L

R

Q

T

Q

I

L

S

T

G

R

L

A

L

W

R

D

P

P

K

Q

A

Q

G

G

E

E

V

I

R

L

L

L

D

N

G

D

R

S

P

P

L

I

S

A

S

S

I

L

P

N

A

E

H

A

G

A

L

L

V

-

G

R

A

Q

G

T

V

I

S

S

H

V

V

V

P

P

E
x
Q

G

R

R

V

R

H

V

L

F

F

P

-

S

S

M

A

S

T

V

L

R

R

E

D

N

N

L

L

L

L

M

L

G

A

A

S

Y

P

H

G

D

S

R

S

R

D

H

E

A

A

R

L

A

S

D

E

L

I

E

L

R

R

V

R

V

V

A

G

L

L

F

E

P

K

R

L

L

L

A

E

E

D

-

A

-

G

-

L

-

N

-

S

R

W

I

L

G

G

Q

E

A

G

G

G

G

R

T

Q

L

L

S

S

G

G

G

G

E

E

Q

L

Q

R

M

R

L

L

A

A

I

I

G

A

R

R

A

A

L

L

M

L

S

H

R

D

P

A

R

P

L

L

I

V

L

L

L

L

D

D

E
|
E

P

P

S

T

M

E

G

G

L

L

A

D

P

A

M

T

I

T

V

E

Q

S

T

Q

I

I

F

L

E

E

V

L

I

L

A

A

E

E

I

M

N

M

R

R

E

E

G

K

V

-

A

T

V

V

L

L

L

M

V

V

E

T

Q

H

N

R

A

L

A

R

S

G

A

L

L

S

R

R

I

F

A

Q

G

-

R

Q

G

I

Y

I

V

V

L

M

E

D

T

N

G

G

R

Q

V

I

V

I

L

E

A

Q

D

G

T

T

A

H

A

A

A

E

L

L

L

L

A

A

binding phosphoaminophosphonic acid-adenylate ester: Y348 (= Y12), Q351 (≠ G13), G376 (= G38), C377 (≠ A39), G378 (= G40), K379 (= K41), S380 (≠ T42), T381 (= T43), Q421 (≠ E84), E500 (= E159)
binding magnesium ion: S380 (≠ T42), Q421 (≠ E84)

7zdfC If(heme/confined) conformation of cyddc in amp-pnp(cydd) bound state (dataset-4) (see paper)
35% identity, 82% coverage: 3:222/267 of query aligns to 339:561/573 of 7zdfC

query
sites
7zdfC

L

L

T

T

L

L

S

R

D

D

V

V

E

Q

V

F

A

T

Y

Y

-

P

-

E

G

Q

A

S

V

Q

T

Q

A

A

L

L

R

K

G

G

V

I

S

S

L

L

E

Q

V

V

A

N

E

A

G

G

E

E

I

H

V

I

T

A

L

I

L

L

G

G

A

R

N

T

G

G

A

C

G

G

K

K

T

S

T

T

T

L

L

L

R

Q

T

Q

I

L

S

T

G

R

L

A

L

W

R

D

P

P

K

Q

A

Q

G

G

E

E

V

I

R

L

L

L

D

N

G

D

R

S

P

P

L

I

S

A

S

S

I

L

P

N

A

E

H

A

G

A

L

L

V

-

G

R

A

Q

G

T

V

I

S

S

H

V

V

V

P

P

E

Q

G

R

R

V

R

H

V

L

F

F

P

-

S

S

M

A

S

T

V

L

R

R

E

D

N

N

L

L

L

L

M

L

G

A

A

S

Y

P

H

G

D

S

R

S

R

D

H

E

A

A

R

L

A

S

D

E

L

I

E

L

R

R

V

R

V

V

A

G

L

L

F

E

P

K

R

L

L

L

A

E

E

D

-

A

-

G

-

L

-

N

-

S

R

W

I

L

G

G

Q

E

A

G

G

G

G

R

T

Q

L

L

S

S

G

G

G

G

E

E

Q

L

Q

R

M

R

L

L

A

A

I

I

G

A

R

R

A

A

L

L

M

L

S

H

R

D

P

A

R

P

L

L

I

V

L

L

L

L

D

D

E

E

P

P

S

T

M

E

G

G

L

L

A

D

P

A

M

T

I

T

V

E

Q

S

T

Q

I

I

F

L

E

E

V

L

I

L

A

A

E

E

I

M

N

M

R

R

E

E

G

K

V

-

A

T

V

V

L

L

L

M

V

V

E

T

Q

H

N

R

A

L

A

R

S

G

A

L

L

S

R

R

I

F

A

Q

G

-

R

Q

G

I

Y

I

V

V

L

M

E

D

T

N

G

G

R

Q

V

I

V

I

L

E

A

Q

D

G

T

T

A

H

A

A

A

E

L

L

L

L

A

A

Sites not aligning to the query:

binding {3,3'-[(9S)-8,13-diethenyl-3,7,12,17-tetramethyl-9,10-dihydroporphyrin-2,18-diyl-kappa~4~N~21~,N~22~,N~23~,N~24~]dipropanoato(2-)}iron: 85, 89, 135

7zdaC If(apo/asym) conformation of cyddc in adp+pi(cydc)/atp(cydd) bound state (dataset-2) (see paper)
35% identity, 82% coverage: 3:222/267 of query aligns to 339:561/572 of 7zdaC

query
sites
7zdaC

L

L

T

T

L

L

S

R

D

D

V

V

E

Q

V

F

A

T

Y
|
Y

-

P

-

E

G

Q

A

S

V

Q

T

Q

A

A

L

L

R

K

G

G

V

I

S

S

L

L

E

Q

V

V

A

N

E

A

G

G

E

E

I

H

V

I

T

A

L

I

L

L

G

G

A

R

N

T

G
|
G

A

C

G
|
G

K
|
K

T
x
S

T
|
T

T

L

L

L

R

Q

T

Q

I

L

S

T

G

R

L

A

L

W

R

D

P

P

K

Q

A

Q

G

G

E

E

V

I

R

L

L

L

D

N

G

D

R

S

P

P

L

I

S

A

S

S

I

L

P

N

A

E

H

A

G

A

L

L

V

-

G

R

A

Q

G

T

V

I

S

S

H

V

V

V

P

P

E
x
Q

G

R

R

V

R

H

V

L

F

F

P

-

S

S

M

A

S

T

V

L

R

R

E

D

N

N

L

L

L

L

M

L

G

A

A

S

Y

P

H

G

D

S

R

S

R

D

H

E

A

A

R

L

A

S

D

E

L

I

E

L

R

R

V

R

V

V

A

G

L

L

F

E

P

K

R

L

L

L

A

E

E

D

-

A

-

G

-

L

-

N

-

S

R

W

I

L

G

G

Q

E

A

G

G

G

G

R

T

Q

L

L

S

S

G

G

G

G

E

E

Q

L

Q

R

M

R

L

L

A

A

I

I

G

A

R

R

A

A

L

L

M

L

S

H

R

D

P

A

R

P

L

L

I

V

L

L

L

L

D

D

E

E

P

P

S

T

M

E

G

G

L

L

A

D

P

A

M

T

I

T

V

E

Q

S

T

Q

I

I

F

L

E

E

V

L

I

L

A

A

E

E

I

M

N

M

R

R

E

E

G

K

V

-

A

T

V

V

L

L

L

M

V

V

E

T

Q

H

N

R

A

L

A

R

S

G

A

L

L

S

R

R

I

F

A

Q

G

-

R

Q

G

I

Y

I

V

V

L

M

E

D

T

N

G

G

R

Q

V

I

V

I

L

E

A

Q

D

G

T

T

A

H

A

A

A

E

L

L

L

L

A

A

binding adenosine-5'-diphosphate: Y348 (= Y12), G376 (= G38), G378 (= G40), K379 (= K41), S380 (≠ T42), T381 (= T43)
binding magnesium ion: S380 (≠ T42), Q421 (≠ E84)

Sites not aligning to the query:

binding adenosine-5'-diphosphate: 112

8ipsA Cryo-em structure of heme transporter cyddc from escherichia coli in the inward facing heme loading state (see paper)
35% identity, 82% coverage: 3:222/267 of query aligns to 339:561/573 of 8ipsA

query
sites
8ipsA

L

L

T

T

L

L

S

R

D

D

V

V

E

Q

V

F

A

T

Y

Y

-

P

-

E

G

Q

A

S

V

Q

T

Q

A

A

L

L

R

K

G

G

V

I

S

S

L

L

E

Q

V

V

A

N

E

A

G

G

E

E

I

H

V

I

T

A

L

I

L

L

G

G

A

R

N

T

G

G

A

C

G

G

K

K

T

S

T

T

T

L

L

L

R

Q

T

L

I

L

S

T

G

R

L

A

L

W

R

D

P

P

K

Q

A

Q

G

G

E

E

V

I

R

L

L

L

D

N

G

D

R

S

P

P

L

I

S

A

S

S

I

L

P

N

A

E

H

A

G

A

L

L

V

-

G

R

A

Q

G

T

V

I

S

S

H

V

V

V

P

P

E

Q

G

R

R

V

R

H

V

L

F

F

P

-

S

S

M

A

S

T

V

L

R

R

E

D

N

N

L

L

L

L

M

L

G

A

A

S

Y

P

H

G

D

S

R

S

R

D

H

E

A

A

R

L

A

S

D

E

L

I

E

L

R

R

V

R

V

V

A

G

L

L

F

E

P

K

R

L

L

L

A

E

E

D

-

A

-

G

-

L

-

N

-

S

R

W

I

L

G

G

Q

E

A

G

G

G

G

R

T

Q

L

L

S

S

G

G

G

G

E

E

Q

L

Q

R

M

R

L

L

A

A

I

I

G

A

R

R

A

A

L

L

M

L

S

H

R

D

P

A

R

P

L

L

I

V

L

L

L

L

D

D

E

E

P

P

S

T

M

E

G

G

L

L

A

D

P

A

M

T

I

T

V

E

Q

S

T

Q

I

I

F

L

E

E

V

L

I

L

A

A

E

E

I

M

N

M

R

R

E

E

G

K

V

-

A

T

V

V

L

L

L

M

V

V

E

T

Q

H

N

R

A

L

A

R

S

G

A

L

L

S

R

R

I

F

A

Q

G

-

R

Q

G

I

Y

I

V

V

L

M

E

D

T

N

G

G

R

Q

V

I

V

I

L

E

A

Q

D

G

T

T

A

H

A

A

A

E

L

L

L

L

A

A

Sites not aligning to the query:

binding protoporphyrin ix containing fe: 85, 89, 135, 136

7zdtC Occ(apo/return) conformation of cyddc mutant (e500q.C) in atp(cydc) bound state (dataset-18) (see paper)
35% identity, 82% coverage: 3:222/267 of query aligns to 339:561/572 of 7zdtC

query
sites
7zdtC

L

L

T

T

L

L

S

R

D

D

V

V

E

Q

V

F

A

T

Y
|
Y

-

P

-

E

G

Q

A

S

V

Q

T

Q

A

A

L

L

R

K

G

G

V

I

S

S

L

L

E

Q

V

V

A

N

E

A

G

G

E

E

I

H

V

I

T

A

L

I

L

L

G

G

A

R

N
x
T

G
|
G

A

C

G
|
G

K
|
K

T
x
S

T
|
T

T

L

L

L

R

Q

T

Q

I

L

S

T

G

R

L

A

L

W

R

D

P

P

K

Q

A

Q

G

G

E

E

V

I

R

L

L

L

D

N

G

D

R

S

P

P

L

I

S

A

S

S

I

L

P

N

A

E

H

A

G

A

L

L

V

-

G

R

A

Q

G

T

V

I

S

S

H

V

V

V

P

P

E
x
Q

G

R

R

V

R

H

V

L

F

F

P

-

S

S

M

A

S

T

V

L

R

R

E

D

N

N

L

L

L

L

M

L

G

A

A

S

Y

P

H

G

D

S

R

S

R

D

H

E

A

A

R

L

A

S

D

E

L

I

E

L

R

R

V

R

V

V

A

G

L

L

F

E

P

K

R

L

L

L

A

E

E

D

-

A

-

G

-

L

-

N

-

S

R

W

I

L

G

G

Q

E

A

G

G

G

G

R

T

Q

L

L

S

S

G

G

G

G

E

E

Q

L

Q

R

M

R

L

L

A

A

I

I

G

A

R

R

A

A

L

L

M

L

S

H

R

D

P

A

R

P

L

L

I

V

L

L

L

L

D

D

E

Q

P

P

S

T

M

E

G

G

L

L

A

D

P

A

M

T

I

T

V

E

Q

S

T

Q

I

I

F

L

E

E

V

L

I

L

A

A

E

E

I

M

N

M

R

R

E

E

G

K

V

-

A

T

V

V

L

L

L

M

V

V

E

T

Q
x
H

N

R

A

L

A

R

S

G

A

L

L

S

R

R

I

F

A

Q

G

-

R

Q

G

I

Y

I

V

V

L

M

E

D

T

N

G

G

R

Q

V

I

V

I

L

E

A

Q

D

G

T

T

A

H

A

A

A

E

L

L

L

L

A

A

binding adenosine-5'-triphosphate: Y348 (= Y12), T375 (≠ N37), G376 (= G38), G378 (= G40), K379 (= K41), S380 (≠ T42), T381 (= T43), Q421 (≠ E84), H531 (≠ Q191)
binding magnesium ion: S380 (≠ T42), Q421 (≠ E84)

7zdbC If(heme/bound) conformation of cyddc in adp+pi(cydc)/atp(cydd) bound state (dataset-2) (see paper)
35% identity, 71% coverage: 3:191/267 of query aligns to 339:532/554 of 7zdbC

query
sites
7zdbC

L

L

T

T

L

L

S

R

D

D

V

V

E

Q

V

F

A

T

Y
|
Y

-

P

-

E

G

Q

A

S

V

Q

T

Q

A

A

L

L

R

K

G

G

V

I

S

S

L

L

E

Q

V

V

A

N

E

A

G

G

E

E

I

H

V

I

T

A

L

I

L

L

G

G

A

R

N

T

G
|
G

A

C

G
|
G

K
|
K

T
x
S

T

T

T

L

L

L

R

Q

T

Q

I

L

S

T

G

R

L

A

L

W

R

D

P

P

K

Q

A

Q

G

G

E

E

V

I

R

L

L

L

D

N

G

D

R

S

P

P

L

I

S

A

S

S

I

L

P

N

A

E

H

A

G

A

L

L

V

-

G

R

A

Q

G

T

V

I

S

S

H

V

V

V

P

P

E
x
Q

G

R

R

V

R

H

V

L

F

F

P

-

S

S

M

A

S

T

V

L

R

R

E

D

N

N

L

L

L

L

M

L

G

A

A

S

Y

P

H

G

D

S

R

S

R

D

H

E

A

A

R

L

A

S

D

E

L

I

E

L

R

R

V

R

V

V

A

G

L

L

F

E

P

K

R

L

L

L

A

E

E

D

-

A

-

G

-

L

-

N

-

S

R

W

I

L

G

G

Q

E

A

G

G

G

G

R

T

Q

L

L

S

S

G

G

G

G

E

E

Q

L

Q

R

M

R

L

L

A

A

I

I

G

A

R

R

A

A

L

L

M

L

S

H

R

D

P

A

R

P

L

L

I

V

L

L

L

L

D

D

E
|
E

P

P

S

T

M

E

G

G

L

L

A

D

P

A

M

T

I

T

V

E

Q

S

T

Q

I

I

F

L

E

E

V

L

I

L

A

A

E

E

I

M

N

M

R

R

E

E

G

K

V

T

A

V

V

L

L

M

L

V

V

T

E
x
H

Q

R

binding adenosine-5'-diphosphate: Y348 (= Y12), G376 (= G38), G378 (= G40), K379 (= K41), S380 (≠ T42)
binding magnesium ion: S380 (≠ T42), Q421 (≠ E84)
binding phosphite ion: K379 (= K41), E500 (= E159), H531 (≠ E190)

Sites not aligning to the query:

binding heme b/c: 81, 85, 132, 135

3c4jA Abc protein artp in complex with atp-gamma-s
28% identity, 78% coverage: 2:210/267 of query aligns to 3:221/242 of 3c4jA

query
sites
3c4jA

L

M

L

I

T

D

L

V

S

H

D

Q

V

L

E

K

V

K

A

S

Y
x
F

G

G

A

S

V

L

T

E

A
x
V

L

L

R

K

G

G

V

I

S

N

L

V

E

H

V

I

A

R

E

E

G

G

E

E

I

V

V

V

T

V

L

V

L

I

G

G

A

P

N
x
S

G
|
G

A
x
S

G
|
G

K
|
K

T
x
S

T
|
T

T

F

L

L

R

R

T

C

I

L

S

N

G

L

L

L

L

E

R

D

P

F

K

D

A

E

G

G

E

E

V

I

R

I

L

I

D

D

G

G

R

I

P

N

L

L

S

K

S

A

I

K

P

D

A

T

H

N

-

L

G

N

L

K

V

V

G

R

A

E

G

E

V

V

S

G

H

M

V

V

P

F

E

Q

G

R

R

F

R

N

V

L

F

F

P

P

S

H

M

M

S

T

V

V

R

L

E

N

N

N

L

I

L

T

M

L

G

A

A

P

Y

M

H

K

D

V

R

R

R

K

H

W

A

P

R

R

A

E

D

K

L

A

E

E

-

A

R

K

V

A

V

M

A

E

L

L

F

L

P

D

R

K

-

V

-

G

L

L

A

K

E

D

R

K

I

A

G

H

Q

A

A

Y

G

P

G

D

T

S

L

L

S

S

G

G

G

G

E

Q

Q

A

Q

Q

M

R

L

V

A

A

I

I

G

A

R

R

A

A

L

L

M

A

S

M

R

E

P

P

R

K

L

I

I

M

L

L

L

F

D

D

E

E

P

P

S

T

M

S

G

A

L

L

A

D

P

P

M

E

I

M

V

V

Q

G

T

E

I

V

F

L

E

S

V

V

I

M

A

K

E

Q

I

L

N

A

R

N

E

E

G

G

V

M

A

T

V

M

L

V

L

V

V

V

E

T

Q

H

N

E

A

M

A

G

S

F

A

A

L

R

R

E

I

V

A

G

G

D

R

R

-

V

-

L

-

F

-

M

-

D

-

G

G

G

Y

Y

V

I

L

I

E

E

T

E

G

G

R

K

binding phosphothiophosphoric acid-adenylate ester: F13 (≠ Y12), V18 (≠ A17), S38 (≠ N37), G39 (= G38), S40 (≠ A39), G41 (= G40), K42 (= K41), S43 (≠ T42), T44 (= T43)

Query Sequence

>WP_011601970.1 NCBI__GCF_000058485.1:WP_011601970.1
MLLTLSDVEVAYGAVTALRGVSLEVAEGEIVTLLGANGAGKTTTLRTISGLLRPKAGEVR
LDGRPLSSIPAHGLVGAGVSHVPEGRRVFPSMSVRENLLMGAYHDRRHARADLERVVALF
PRLAERIGQAGGTLSGGEQQMLAIGRALMSRPRLILLDEPSMGLAPMIVQTIFEVIAEIN
REGVAVLLVEQNAASALRIAGRGYVLETGRVVLADTAAALLADDRVRQAYLGEDVAGGPE
VPQGPAPTRGGAAASPAHGAAIRADSA

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory