Comparing WP_011605963.1 NCBI__GCF_000058485.1:WP_011605963.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
P37111 Aminoacylase-1; ACY-1; N-acyl-L-amino-acid amidohydrolase; EC 3.5.1.14 from Sus scrofa (Pig) (see paper)
30% identity, 85% coverage: 67:445/448 of query aligns to 56:394/407 of P37111
Sites not aligning to the query:
Q8C165 N-fatty-acyl-amino acid synthase/hydrolase PM20D1; Peptidase M20 domain-containing protein 1; PM20D1; EC 3.5.1.114; EC 3.5.1.14 from Mus musculus (Mouse) (see paper)
26% identity, 99% coverage: 4:447/448 of query aligns to 41:489/503 of Q8C165
Q03154 Aminoacylase-1; ACY-1; N-acyl-L-amino-acid amidohydrolase; EC 3.5.1.14 from Homo sapiens (Human) (see 6 papers)
29% identity, 85% coverage: 66:445/448 of query aligns to 55:395/408 of Q03154
1q7lA Zn-binding domain of the t347g mutant of human aminoacylase-i (see paper)
36% identity, 34% coverage: 66:219/448 of query aligns to 49:192/192 of 1q7lA
3pfoA Crystal structure of a putative acetylornithine deacetylase (rpa2325) from rhodopseudomonas palustris cga009 at 1.90 a resolution
35% identity, 31% coverage: 22:161/448 of query aligns to 19:175/426 of 3pfoA
Sites not aligning to the query:
P44514 Succinyl-diaminopimelate desuccinylase; SDAP desuccinylase; N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase; EC 3.5.1.18 from Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) (see 3 papers)
28% identity, 53% coverage: 15:252/448 of query aligns to 3:220/377 of P44514
Sites not aligning to the query:
5vo3A Crystal structure of dape in complex with the products (succinic acid and diaminopimelic acid) (see paper)
28% identity, 53% coverage: 15:252/448 of query aligns to 7:224/380 of 5vo3A
Sites not aligning to the query:
4h2kA Crystal structure of the catalytic domain of succinyl-diaminopimelate desuccinylase from haemophilus influenzae (see paper)
29% identity, 35% coverage: 15:170/448 of query aligns to 5:149/258 of 4h2kA
Sites not aligning to the query:
7t1qA Crystal structure of the succinyl-diaminopimelate desuccinylase (dape) from acinetobacter baumannii in complex with succinic acid
29% identity, 48% coverage: 35:247/448 of query aligns to 16:215/377 of 7t1qA
Sites not aligning to the query:
7lgpB Dape enzyme from shigella flexneri
26% identity, 81% coverage: 86:446/448 of query aligns to 63:373/377 of 7lgpB
Q96KP4 Cytosolic non-specific dipeptidase; CNDP dipeptidase 2; Glutamate carboxypeptidase-like protein 1; Peptidase A; Threonyl dipeptidase; EC 3.4.13.18 from Homo sapiens (Human)
32% identity, 32% coverage: 35:176/448 of query aligns to 35:184/475 of Q96KP4
Sites not aligning to the query:
8uw6B Acetylornithine deacetylase from escherichia coli, di-zinc form. (see paper)
30% identity, 41% coverage: 48:229/448 of query aligns to 37:195/381 of 8uw6B
Sites not aligning to the query:
7uoiA Crystallographic structure of dape from enterococcus faecium (see paper)
32% identity, 29% coverage: 12:142/448 of query aligns to 5:127/383 of 7uoiA
Sites not aligning to the query:
2zogA Crystal structure of mouse carnosinase cn2 complexed with zn and bestatin (see paper)
35% identity, 22% coverage: 78:176/448 of query aligns to 90:188/478 of 2zogA
Sites not aligning to the query:
2zofA Crystal structure of mouse carnosinase cn2 complexed with mn and bestatin (see paper)
35% identity, 22% coverage: 78:176/448 of query aligns to 90:188/478 of 2zofA
Sites not aligning to the query:
Q9D1A2 Cytosolic non-specific dipeptidase; CNDP dipeptidase 2; Glutamate carboxypeptidase-like protein 1; Threonyl dipeptidase; EC 3.4.13.18 from Mus musculus (Mouse) (see 2 papers)
35% identity, 22% coverage: 78:176/448 of query aligns to 86:184/475 of Q9D1A2
Sites not aligning to the query:
4pqaA Crystal structure of succinyl-diaminopimelate desuccinylase from neisseria meningitidis mc58 in complex with the inhibitor captopril (see paper)
25% identity, 52% coverage: 16:247/448 of query aligns to 4:215/375 of 4pqaA
Sites not aligning to the query:
4o23A Crystal structure of mono-zinc form of succinyl diaminopimelate desuccinylase from neisseria meningitidis mc58 (see paper)
25% identity, 52% coverage: 16:247/448 of query aligns to 4:215/376 of 4o23A
2pokA Crystal structure of a m20 family metallo peptidase from streptococcus pneumoniae
29% identity, 33% coverage: 42:187/448 of query aligns to 44:187/458 of 2pokA
Sites not aligning to the query:
3dljA Crystal structure of human carnosine dipeptidase 1
28% identity, 45% coverage: 48:247/448 of query aligns to 59:250/471 of 3dljA
Sites not aligning to the query:
>WP_011605963.1 NCBI__GCF_000058485.1:WP_011605963.1
MSAADLSAGRRVAAREAVAMASDLIAFDTSNHGDPHVRGTERPAAEYVAGRLADVGYDVT
YLESGAPGRGNVVARLPGADPSRGALLLHGHLDVVPADAADWSVHPFSGEVRDGYVWGRG
AVDMKGAVAIMLAVARRLRREGAIPPRDLIFAFVADEEAGGWHGARWLVDNRPDLFEGAT
EAIGEVGGFSVTLGSATGGEDVRAYLVQTAEKGSMWLRLAARGRGGHGSMLHDDNAIATL
AAAVARLDVHRFPLVLTEPIRALLTGIADITGIPFDEADPQSAVDRLGPLARLIGAALRD
TANVTLFDAGYRSNVVPVTAHATVDGRFLPGREEAFGRELVEVLGPGVRAAWDTLPPVRT
DVDGALMAAIAAAIEAEDPGARVLPYLLAAGTDAKSFQRLGIRHLGFTPLRLPPELDFSA
LFHGVDERVPVAALEFGTRVLDRLLRTC
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory