SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing WP_011649173.1 NCBI__GCF_000009265.1:WP_011649173.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

1g6hA Crystal structure of the adp conformation of mj1267, an atp-binding cassette of an abc transporter (see paper)
32% identity, 98% coverage: 5:256/257 of query aligns to 2:253/254 of 1g6hA

query
sites
1g6hA

L

M

P

E

L

I

L

L

E

R

I

T

K

E

N

N

L

I

S

V

K

K

S

Y

Y
x
F

G

G

A

E

V
x
F

K

K

A

A

V

L

N

D

D

G

V

V

S

S

I

I

H

S

I

V

D

N

R

K

G

G

E

D

I

V

A

T

G

L

L

I

I

I

G

G

P

P

N
|
N

G
|
G

S

S

G
|
G

K
|
K

S
|
S

T
|
T

F

L

F

I

D

N

C

V

S

I

T

T

G

G

L

F

A

L

K

K

P

A

D

D

T

E

G

G

T

R

V

V

V

Y

L

F

D

E

G

N

Q

K

D

D

I

I

T

T

G

N

W

K

S

E

L

P

N

A

R

E

I

L

A

Y

R

H

E

Y

G

G

R

-

M

I

L

V

R

R

S

T

F

F

Q

Q

K

T

T

P

V

Q

T

P

F

L

R

K

S

E

L

M

D

T

V

V

E

L

E

E

N

N

L

L

V

L

I

I

A

G

G

E

Q

I

M

C

F

P

T

G

F

E

P

S

S

P

I

L

T

N

S

S

T

L

F

F

G

Y

L

K

G

K

K

W

M

I

S

P

R

K

Q

E

R

E

V

-

G

-

G

E

L

M

R

V

E

E

R

K

A

A

R

F

D

K

L

I

I

L

K

E

M

F

A

L

G

K

L

L

W

S

D

H

V

L

R

Y

H

D

Q

R

P

K

A

A

G

G

N

E

L

L

S

S

G

G

G

G

Q

Q

Q

M

K

K

L

L

I

V

Q

E

F

I

A

G

S

R

M

A

L

L

M

M

P

T

E

N

P

P

K

K

L

M

I

I

L

V

L

M

D

D

E

E

P

P

M

I

A

A

G

G

I

V

N

A

P

P

K

G

I

L

I

A

E

H

R

D

V

I

V

F

D

N

T

H

I

V

R

L

Y

E

A

L

N

-

K

K

S

A

L

K

G

G

V

I

S

T

F

F

L

L

V

I

I

I

E

E

H

H

N

R

I

L

D

D

V

I

V

V

T

L

S

N

I

Y

C

I

Q

D

R

H

V

L

I

Y

V

V

L

M

D

F

Q

N

G

G

A

Q

K

I

L

I

V

A

E

E

G

G

L

R

P

G

-

E

-

E

-

E

-

I

G

K

D

N

I

V

I

L

Q

S

D

D

Q

P

R

K

V

V

R

V

E

E

A

I

Y

Y

L

I

G

G

binding adenosine-5'-diphosphate: F14 (≠ Y17), F17 (≠ V20), N39 (= N42), G40 (= G43), G42 (= G45), K43 (= K46), S44 (= S47), T45 (= T48)

6mjpA Lptb(e163q)fgc from vibrio cholerae (see paper)
32% identity, 97% coverage: 7:256/257 of query aligns to 2:235/240 of 6mjpA

query
sites
6mjpA

L

I

L

L

E

K

I

A

K

Q

N

H

L

L

S

A

K

K

S

S

Y

Y

G

K

A

K

V

R

K

K

A

V

V

V

N

S

D

D

V

V

S

S

I

L

H

Q

I

V

D

E

R

S

G

G

E

Q

I

I

A

V

G

G

L

L

I

L

G

G

P

P

N

N

G

G

S

A

G

G

K

K

S

T

T

T

F

S

F

F

D

Y

C

M

S

I

T

V

G

G

L

L

A

V

K

A

P

R

D

D

T

E

G

G

T

T

V

I

V

T

L

I

D

D

G

D

Q

N

D

D

I

I

T

S

G

I

W

L

S

P

L

M

N

H

R

S

I

R

A

S

R

R

E

M

G

G

R

-

M

I

L

G

R

Y

S

L

F

P

Q

Q

K

E

T

A

V

S

T

I

F

F

R

R

S

K

L

L

D

S

V

V

E

E

E

D

N

N

L

I

V

M

I

A

A

V

G

L

Q

Q

M

-

F

-

T

T

F

R

P

E

S

E

I

L

T

T

S

H

T
x
E

F

-

G

-

L

-

G

-

K

-

M

-

S

E

R

R

Q

Q

R

-

V

-

G

-

G

-

L

-

R

-

E
x
D

R

K

A

L

R

E

D

D

L

L

I

L

K

E

M

E

A

F

G

H

L

I

W

Q

D

H

V

I

R

R

H

K

Q

S

P

A

A

G

G

M

N

A

L

L

S

S

G

G

G

G

Q

E

Q

R

K

R

L

R

I

V

Q

E

F

I

A

A

S

R

M

A

L

L

M

A

P

A

E

N

P

P

K

Q

L

F

I

I

L

L

L

L

D

D

E

Q

P

P

M

F

A

A

G

G

I

V

N

D

P

P

K

I

I

S

-

V

-

I

-

D

I

I

E

K

R

K

V

I

V

I

D

E

T

H

I

L

R

R

Y

-

A

-

N

D

K

R

S

G

L

L

G

G

V

V

S

-

F

-

L

L

V

I

I

T

E

D

H

H

N

N

I

V

D

R

V

E

V

T

T

L

S

D

I

V

C

C

Q

E

R

K

V

A

I

Y

V

I

L

V

D

S

Q

Q

G

G

A

R

K

L

L

I

V

A

E

E

G

G

L

T

P

P

G

Q

D

D

I

V

I

L

Q

N

D

N

Q

E

R

Q

V

V

R

K

E

Q

A

V

Y

Y

L

L

G

G

binding calcium ion: E111 (≠ T119), D115 (≠ E135)

1g9xB Characterization of the twinning structure of mj1267, an atp-binding cassette of an abc transporter (see paper)
32% identity, 98% coverage: 5:256/257 of query aligns to 2:253/253 of 1g9xB

query
sites
1g9xB

L

M

P

E

L

I

L

L

E

R

I

T

K

E

N

N

L

I

S

V

K

K

S

Y

Y
x
F

G

G

A

E

V
x
F

K

K

A

A

V

L

N

D

D

G

V

V

S

S

I

I

H

S

I

V

D

C

R

K

G

G

E

D

I

V

A

T

G

L

L

I

I

I

G

G

P

P

N

N

G
|
G

S
|
S

G
|
G

K
|
K

S
|
S

T
|
T

F

L

F

I

D

N

C

V

S

I

T

T

G

G

L

F

A

L

K

K

P

A

D

D

T

E

G

G

T

R

V

V

V

Y

L

F

D

E

G

N

Q

K

D

D

I

I

T

T

G

N

W

K

S

E

L

P

N

A

R

E

I

L

A

Y

R

H

E

Y

G

G

R

-

M

I

L

V

R

R

S

T

F

F

Q

Q

K

T

T

P

V

Q

T

P

F

L

R

K

S

E

L

M

D

T

V

V

E

L

E

E

N

N

L

L

V

L

I

I

A

G

G

E

Q

I

M

N

F

P

T

G

F

E

P

S

S

P

I

L

T

N

S

S

T

L

F

F

G

Y

L

K

G

K

K

W

M

I

S

P

R

K

Q

E

R

E

V

-

G

-

G

E

L

M

R

V

E

E

R

K

A

A

R

F

D

K

L

I

I

L

K

E

M

F

A

L

G

K

L

L

W

S

D

H

V

L

R

Y

H

D

Q

R

P

K

A

A

G

G

N

E

L

L

S

S

G

G

G

G

Q

Q

Q

M

K

K

L

L

I

V

Q

E

F

I

A

G

S

R

M

A

L

L

M

M

P

T

E

N

P

P

K

K

L

M

I

I

L

V

L

M

D

D

E
|
E

P

P

M

I

A

A

G

G

I

V

N

A

P

P

K

G

I

L

I

A

E

H

R

D

V

I

V

F

D

N

T

H

I

V

R

L

Y

E

A

L

N

-

K

K

S

A

L

K

G

G

V

I

S

T

F

F

L

L

V

I

I

I

E

E

H

H

N

R

I

L

D

D

V

I

V

V

T

L

S

N

I

Y

C

I

Q

D

R

H

V

L

I

Y

V

V

L

M

D

F

Q

N

G

G

A

Q

K

I

L

I

V

A

E

E

G

G

L

R

P

G

-

E

-

E

-

E

-

I

G

K

D

N

I

V

I

L

Q

S

D

D

Q

P

R

K

V

V

R

V

E

E

A

I

Y

Y

L

I

G

G

binding adenosine-5'-diphosphate: F14 (≠ Y17), F17 (≠ V20), G40 (= G43), S41 (= S44), G42 (= G45), K43 (= K46), S44 (= S47), T45 (= T48)
binding magnesium ion: S44 (= S47), E176 (= E182)

6s8nB Cryo-em structure of lptb2fgc in complex with lipopolysaccharide (see paper)
35% identity, 97% coverage: 8:256/257 of query aligns to 3:235/238 of 6s8nB

query
sites
6s8nB

L

L

E

T

I

A

K

K

N

N

L

L

S

A

K

K

S

A

Y

Y

G

K

A

G

V

R

K

R

A

V

V

V

N

E

D

D

V

V

S

S

I

L

H

T

I

V

D

N

R

S

G

G

E

E

I

I

A

V

G

G

L

L

I

L

G

G

P

P

N

N

G

G

S

A

G

G

K

K

S

T

T

T

F

T

F

F

D

Y

C

M

S

V

T

V

G

G

L

I

A

V

K

P

P

R

D

D

T

A

G

G

T

N

V

I

V

I

L

I

D

D

G

D

Q

D

D

D

I

I

T

S

G

L

W

L

S

P

L

L

N

H

R

A

I

R

A

A

R

R

E

R

G

G

R

-

M

I

L

G

R

Y

S

L

F

P

Q

Q

K

E

T

A

V

S

T

I

F

F

R
|
R

S

R

L

L

D

S

V

V

E

Y

E

D

N

N

L

L

V

M

I

A

A

V

G

L

Q

Q

M

I

F

R

T

D

F

D

P

L

S

S

I

-

T

-

S

-

T

-

F

-

G

-

L

-

G

-

K

-

M

-

S

A

R

E

Q

Q

R

R

V

-

G

-

G

-

L

-

R

E

E

D

R

R

A

A

R

N

D

E

L

L

I

M

K

E

M

E

A

F

G

H

L

I

W

E

D

H

V

L

R

R

H

D

Q

S

P
x
M

A
x
G

G
x
Q

N

S

L

L

S

S

G

G

G

G

Q

E

Q

R

K

R

L

R

I

V

Q

E

F

I

A

A

S

R

M

A

L

L

M

A

P

A

E

N

P

P

K

K

L

F

I

I

L

L

L

L

D

D

E

E

P

P

M

F

A

A

G

G

I

V

N

D

P

P

K

I

I

S

-

V

-

I

-

D

I

I

E

K

R

R

V

I

V

I

D

E

T

H

I

L

R

R

Y

-

A

-

N

D

K

S

S

G

L

L

G

G

V

V

S

-

F

-

L

L

V

I

I

T

E

D

H

H

N

N

I

V

D

R

V

E

V

T

T

L

S

A

I

V

C

C

Q

E

R

R

V

A

I

Y

V

I

L

V

D

S

Q

Q

G

G

A

H

K

L

L

I

V

A

E

H

G

G

L

T

P

P

G

T

D

E

I

I

I

L

Q

Q

D

D

Q

E

R

H

V

V

R

K

E

R

A

V

Y

Y

L

L

G

G

binding 2-decyl-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione: R90 (= R96), M133 (≠ P153), G134 (≠ A154), Q135 (≠ G155)

6s8gA Cryo-em structure of lptb2fgc in complex with amp-pnp (see paper)
35% identity, 97% coverage: 8:256/257 of query aligns to 3:235/238 of 6s8gA

query
sites
6s8gA

L

L

E

T

I

A

K

K

N

N

L

L

S

A

K

K

S

A

Y
|
Y

G

K

A

G

V
x
R

K

R

A

V

V

V

N

E

D

D

V

V

S

S

I

L

H

T

I

V

D

N

R

S

G

G

E

E

I

I

A

V

G

G

L

L

I

L

G

G

P

P

N
|
N

G

G

S

A

G
|
G

K
|
K

S
x
T

T
|
T

F

T

F

F

D

Y

C

M

S

V

T

V

G

G

L

I

A

V

K

P

P

R

D

D

T

A

G

G

T

N

V

I

V

I

L

I

D

D

G

D

Q

D

D

D

I

I

T

S

G

L

W

L

S

P

L

L

N

H

R

A

I

R

A

A

R

R

E

R

G

G

R

-

M

I

L

G

R

Y

S

L

F

P

Q
|
Q

K

E

T

A

V

S

T

I

F

F

R

R

S

R

L

L

D

S

V

V

E

Y

E

D

N

N

L

L

V

M

I

A

A

V

G

L

Q

Q

M

I

F

R

T

D

F

D

P

L

S

S

I

-

T

-

S

-

T

-

F

-

G

-

L

-

G

-

K

-

M

-

S

A

R

E

Q

Q

R

R

V

-

G

-

G

-

L

-

R

E

E

D

R

R

A

A

R

N

D

E

L

L

I

M

K

E

M

E

A

F

G

H

L

I

W

E

D

H

V

L

R

R

H

D

Q

S

P

M

A

G

G

Q

N
x
S

L

L

S
|
S

G

G

G

G

Q
x
E

Q

R

K

R

L

R

I

V

Q

E

F

I

A

A

S

R

M

A

L

L

M

A

P

A

E

N

P

P

K

K

L

F

I

I

L

L

L

L

D

D

E

E

P

P

M

F

A

A

G

G

I

V

N

D

P

P

K

I

I

S

-

V

-

I

-

D

I

I

E

K

R

R

V

I

V

I

D

E

T

H

I

L

R

R

Y

-

A

-

N

D

K

S

S

G

L

L

G

G

V

V

S

-

F

-

L

L

V

I

I

T

E

D

H

H

N

N

I

V

D

R

V

E

V

T

T

L

S

A

I

V

C

C

Q

E

R

R

V

A

I

Y

V

I

L

V

D

S

Q

Q

G

G

A

H

K

L

L

I

V

A

E

H

G

G

L

T

P

P

G

T

D

E

I

I

I

L

Q

Q

D

D

Q

E

R

H

V

V

R

K

E

R

A

V

Y

Y

L

L

G

G

binding phosphoaminophosphonic acid-adenylate ester: Y12 (= Y17), R15 (≠ V20), N37 (= N42), G40 (= G45), K41 (= K46), T42 (≠ S47), T43 (= T48), Q84 (= Q90), S136 (≠ N156), S138 (= S158), E141 (≠ Q161)

6mhzA Vanadate trapped cryo-em structure of e.Coli lptb2fg transporter (see paper)
35% identity, 97% coverage: 8:256/257 of query aligns to 3:235/235 of 6mhzA

query
sites
6mhzA

L

L

E

T

I

A

K

K

N

N

L

L

S

A

K

K

S

A

Y
|
Y

G

K

A

G

V

R

K

R

A

V

V

V

N

E

D

D

V

V

S

S

I

L

H

T

I

V

D

N

R

S

G

G

E

E

I

I

A

V

G

G

L

L

I

L

G

G

P

P

N
|
N

G
|
G

S

A

G
|
G

K
|
K

S
x
T

T
|
T

F

T

F

F

D

Y

C

M

S

V

T

V

G

G

L

I

A

V

K

P

P

R

D

D

T

A

G

G

T

N

V

I

V

I

L

I

D

D

G

D

Q

D

D

D

I

I

T

S

G

L

W

L

S

P

L

L

N

H

R

A

I

R

A

A

R

R

E

R

G

G

R

-

M

I

L

G

R

Y

S

L

F

P

Q
|
Q

K

E

T

A

V

S

T

I

F

F

R

R

S

R

L

L

D

S

V

V

E

Y

E

D

N

N

L

L

V

M

I

A

A

V

G

L

Q

Q

M

I

F

R

T

D

F

D

P

L

S

S

I

-

T

-

S

-

T

-

F

-

G

-

L

-

G

-

K

-

M

-

S

A

R

E

Q

Q

R

R

V

-

G

-

G

-

L

-

R

E

E

D

R

R

A

A

R

N

D

E

L

L

I

M

K

E

M

E

A

F

G

H

L

I

W

E

D

H

V

L

R

R

H

D

Q

S

P

M

A

G

G

Q

N
x
S

L

L

S
|
S

G
|
G

G
|
G

Q

E

Q

R

K

R

L

R

I

V

Q

E

F

I

A

A

S

R

M

A

L

L

M

A

P

A

E

N

P

P

K

K

L

F

I

I

L

L

L

L

D

D

E
|
E

P

P

M

F

A

A

G
|
G

I

V

N

D

P

P

K

I

I

S

-

V

-

I

-

D

I

I

E

K

R

R

V

I

V

I

D

E

T

H

I

L

R

R

Y

-

A

-

N

D

K

S

S

G

L

L

G

G

V

V

S

-

F

-

L

L

V

I

I

T

E

D

H
|
H

N

N

I

V

D

R

V

E

V

T

T

L

S

A

I

V

C

C

Q

E

R

R

V

A

I

Y

V

I

L

V

D

S

Q

Q

G

G

A

H

K

L

L

I

V

A

E

H

G

G

L

T

P

P

G

T

D

E

I

I

I

L

Q

Q

D

D

Q

E

R

H

V

V

R

K

E

R

A

V

Y

Y

L

L

G

G

binding adp orthovanadate: Y12 (= Y17), N37 (= N42), G38 (= G43), G40 (= G45), K41 (= K46), T42 (≠ S47), T43 (= T48), Q84 (= Q90), S136 (≠ N156), S138 (= S158), G139 (= G159), G140 (= G160), E162 (= E182), G166 (= G186), H194 (= H215)

6mbnA Lptb e163q in complex with atp (see paper)
34% identity, 97% coverage: 8:256/257 of query aligns to 4:236/241 of 6mbnA

query
sites
6mbnA

L

L

E

T

I

A

K

K

N

N

L

L

S

A

K

K

S

A

Y
|
Y

G

K

A

G

V
x
R

K

R

A
x
V

V

V

N

E

D

D

V

V

S

S

I

L

H

T

I

V

D

N

R

S

G

G

E

E

I

I

A

V

G

G

L

L

I

L

G

G

P

P

N
|
N

G
|
G

S

A

G
|
G

K
|
K

S
x
T

T
|
T

F

T

F

F

D

Y

C

M

S

V

T

V

G

G

L

I

A

V

K

P

P

R

D

D

T

A

G

G

T

N

V

I

V

I

L

I

D

D

G

D

Q

D

D

D

I

I

T

S

G

L

W

L

S

P

L

L

N

H

R

A

I

R

A

A

R

R

E

R

G

G

R

-

M

I

L

G

R

Y

S

L

F

P

Q

Q

K

E

T

A

V

S

T

I

F

F

R

R

S

R

L

L

D

S

V

V

E

Y

E

D

N

N

L

L

V

M

I

A

A

V

G

L

Q

Q

M

I

F

R

T

D

F

D

P

L

S

S

I

-

T

-

S

-

T

-

F

-

G

-

L

-

G

-

K

-

M

-

S

A

R

E

Q

Q

R

R

V

-

G

-

G

-

L

-

R

E

E

D

R

R

A

A

R

N

D

E

L

L

I

M

K

E

M

E

A

F

G

H

L

I

W

E

D

H

V

L

R

R

H

D

Q

S

P

M

A

G

G

Q

N

S

L

L

S

S

G

G

G

G

Q

E

Q

R

K

R

L

R

I

V

Q

E

F

I

A

A

S

R

M

A

L

L

M

A

P

A

E

N

P

P

K

K

L

F

I

I

L

L

L

L

D

D

E

Q

P

P

M

F

A

A

G

G

I

V

N

D

P

P

K

I

I

S

-

V

-

I

-

D

I

I

E

K

R

R

V

I

V

I

D

E

T

H

I

L

R

R

Y

-

A

-

N

D

K

S

S

G

L

L

G

G

V

V

S

-

F

-

L

L

V

I

I

T

E

D

H
|
H

N

N

I

V

D

R

V

E

V

T

T

L

S

A

I

V

C

C

Q

E

R

R

V

A

I

Y

V

I

L

V

D

S

Q

Q

G

G

A

H

K

L

L

I

V

A

E

H

G

G

L

T

P

P

G

T

D

E

I

I

I

L

Q

Q

D

D

Q

E

R

H

V

V

R

K

E

R

A

V

Y

Y

L

L

G

G

binding adenosine-5'-triphosphate: Y13 (= Y17), R16 (≠ V20), V18 (≠ A22), N38 (= N42), G39 (= G43), G41 (= G45), K42 (= K46), T43 (≠ S47), T44 (= T48), H195 (= H215)

6b89A E. Coli lptb in complex with adp and novobiocin (see paper)
34% identity, 96% coverage: 8:255/257 of query aligns to 3:234/234 of 6b89A

query
sites
6b89A

L

L

E

T

I

A

K

K

N

N

L

L

S

A

K

K

S

A

Y
|
Y

G

K

A

G

V
x
R

K

R

A
x
V

V

V

N

E

D

D

V

V

S

S

I

L

H

T

I

V

D

N

R

S

G

G

E

E

I

I

A

V

G

G

L

L

I

L

G

G

P

P

N
|
N

G
|
G

S

A

G
|
G

K
|
K

S
x
T

T
|
T

F

T

F

F

D

Y

C

M

S

V

T

V

G

G

L

I

A

V

K

P

P

R

D

D

T

A

G

G

T

N

V

I

V

I

L

I

D

D

G

D

Q

D

D

D

I

I

T

S

G

L

W

L

S

P

L
|
L

N
x
H

R

A

I

R

A

A

R

R

E

R

G

G

R

-

M

I

L

G

R

Y

S

L

F
x
P

Q
|
Q

K

E

T
x
A

V
x
S

T

I

F
|
F

R
|
R

S
x
R

L
|
L

D

S

V

V

E

Y

E

D

N

N

L

L

V

M

I

A

A
x
V

G

L

Q

Q

M

I

F

R

T

D

F

D

P

L

S

S

I

-

T

-

S

-

T

-

F

-

G

-

L

-

G

-

K

-

M

-

S

A

R

E

Q

Q

R

R

V

-

G

-

G

-

L

-

R

E

E

D

R

R

A

A

R

N

D

E

L

L

I

M

K

E

M

E

A

F

G

H

L

I

W

E

D

H

V

L

R

R

H

D

Q

S

P

M

A

G

G
x
Q

N

S

L

L

S

S

G

G

G

G

Q

E

Q

R

K

R

L

R

I

V

Q

E

F

I

A

A

S
x
R

M

A

L

L

M

A

P

A

E

N

P

P

K

K

L

F

I

I

L

L

L

L

D

D

E

E

P

P

M

F

A

A

G

G

I

V

N

D

P

P

K

I

I

S

-

V

-

I

-

D

I

I

E

K

R

R

V

I

V

I

D

E

T

H

I

L

R

R

Y

-

A

-

N

D

K

S

S

G

L

L

G

G

V

V

S

-

F

-

L

L

V

I

I

T

E

D

H

H

N

N

I

V

D

R

V

E

V

T

T

L

S

A

I

V

C

C

Q

E

R

R

V

A

I

Y

V

I

L

V

D

S

Q

Q

G

G

A

H

K

L

L

I

V

A

E

H

G

G

L

T

P

P

G

T

D

E

I

I

I

L

Q

Q

D

D

Q

E

R

H

V

V

R

K

E

R

A

V

Y

Y

L

L

binding adenosine-5'-diphosphate: Y12 (= Y17), R15 (≠ V20), V17 (≠ A22), N37 (= N42), G38 (= G43), G40 (= G45), K41 (= K46), T42 (≠ S47), T43 (= T48)
binding magnesium ion: T42 (≠ S47), Q84 (= Q90)
binding novobiocin: L71 (= L76), H72 (≠ N77), P83 (≠ F89), A86 (≠ T92), S87 (≠ V93), F89 (= F95), R90 (= R96), R91 (≠ S97), L92 (= L98), V101 (≠ A107), Q135 (≠ G155), R149 (≠ S169)

4p31A Crystal structure of a selenomethionine derivative of e. Coli lptb in complex with adp-magensium (see paper)
34% identity, 96% coverage: 8:255/257 of query aligns to 3:234/234 of 4p31A

query
sites
4p31A

L

L

E

T

I

A

K

K

N

N

L

L

S

A

K

K

S

A

Y
|
Y

G

K

A

G

V
x
R

K

R

A
x
V

V

V

N

E

D

D

V

V

S

S

I

L

H

T

I

V

D

N

R

S

G

G

E

E

I

I

A

V

G

G

L

L

I

L

G

G

P

P

N

N

G
|
G

S

A

G
|
G

K
|
K

S
x
T

T
|
T

F

T

F

F

D

Y

C

M

S

V

T

V

G

G

L

I

A

V

K

P

P

R

D

D

T

A

G

G

T

N

V

I

V

I

L

I

D

D

G

D

Q

D

D

D

I

I

T

S

G

L

W

L

S

P

L

L

N

H

R

A

I

R

A

A

R

R

E

R

G

G

R

-

M

I

L

G

R

Y

S

L

F

P

Q
|
Q

K

E

T

A

V

S

T

I

F

F

R

R

S

R

L

L

D

S

V

V

E

Y

E

D

N

N

L

L

V

M

I

A

A

V

G

L

Q

Q

M

I

F

R

T

D

F

D

P

L

S

S

I

-

T

-

S

-

T

-

F

-

G

-

L

-

G

-

K

-

M

-

S

A

R

E

Q

Q

R

R

V

-

G

-

G

-

L

-

R

E

E

D

R

R

A

A

R

N

D

E

L

L

I

M

K

E

M

E

A

F

G

H

L

I

W

E

D

H

V

L

R

R

H

D

Q

S

P

M

A

G

G

Q

N

S

L

L

S

S

G

G

G

G

Q

E

Q

R

K

R

L

R

I

V

Q

E

F

I

A

A

S

R

M

A

L

L

M

A

P

A

E

N

P

P

K

K

L

F

I

I

L

L

L

L

D

D

E

E

P

P

M

F

A

A

G

G

I

V

N

D

P

P

K

I

I

S

-

V

-

I

-

D

I

I

E

K

R

R

V

I

V

I

D

E

T

H

I

L

R

R

Y

-

A

-

N

D

K

S

S

G

L

L

G

G

V

V

S

-

F

-

L

L

V

I

I

T

E

D

H

H

N

N

I

V

D

R

V

E

V

T

T

L

S

A

I

V

C

C

Q

E

R

R

V

A

I

Y

V

I

L

V

D

S

Q

Q

G

G

A

H

K

L

L

I

V

A

E

H

G

G

L

T

P

P

G

T

D

E

I

I

I

L

Q

Q

D

D

Q

E

R

H

V

V

R

K

E

R

A

V

Y

Y

L

L

binding adenosine-5'-diphosphate: Y12 (= Y17), R15 (≠ V20), V17 (≠ A22), G38 (= G43), G40 (= G45), K41 (= K46), T42 (≠ S47), T43 (= T48)
binding magnesium ion: T42 (≠ S47), Q84 (= Q90)

6b8bA E. Coli lptb in complex with adp and a novobiocin derivative (see paper)
34% identity, 96% coverage: 8:254/257 of query aligns to 3:233/233 of 6b8bA

query
sites
6b8bA

L

L

E

T

I

A

K

K

N

N

L

L

S

A

K

K

S

A

Y
|
Y

G

K

A

G

V
x
R

K

R

A
x
V

V

V

N

E

D

D

V

V

S

S

I

L

H

T

I

V

D

N

R

S

G

G

E

E

I

I

A

V

G

G

L

L

I

L

G

G

P

P

N

N

G
|
G

S

A

G
|
G

K
|
K

S
x
T

T
|
T

F

T

F

F

D

Y

C

M

S

V

T

V

G

G

L

I

A

V

K

P

P

R

D

D

T

A

G

G

T

N

V

I

V

I

L

I

D

D

G

D

Q

D

D

D

I

I

T

S

G

L

W

L

S

P

L

L

N

H

R

A

I

R

A

A

R

R

E

R

G

G

R

-

M

I

L

G

R

Y

S

L

F

P

Q

Q

K

E

T

A

V

S

T

I

F
|
F

R
|
R

S
x
R

L

L

D

S

V

V

E

Y

E

D

N

N

L

L

V

M

I

A

A

V

G

L

Q

Q

M

I

F

R

T

D

F

D

P

L

S

S

I

-

T

-

S

-

T

-

F

-

G

-

L

-

G

-

K

-

M

-

S

A

R

E

Q

Q

R

R

V

-

G

-

G

-

L

-

R

E

E

D

R

R

A

A

R

N

D

E

L

L

I

M

K

E

M

E

A

F

G

H

L

I

W

E

D

H

V

L

R

R

H

D

Q

S

P

M

A

G

G

Q

N

S

L

L

S

S

G

G

G

G

Q

E

Q

R

K

R

L

R

I

V

Q

E

F

I

A

A

S

R

M

A

L

L

M

A

P

A

E

N

P

P

K

K

L

F

I

I

L

L

L

L

D

D

E

E

P

P

M

F

A

A

G

G

I

V

N

D

P

P

K

I

I

S

-

V

-

I

-

D

I

I

E

K

R

R

V

I

V

I

D

E

T

H

I

L

R

R

Y

-

A

-

N

D

K

S

S

G

L

L

G

G

V

V

S

-

F

-

L

L

V

I

I

T

E

D

H

H

N

N

I

V

D

R

V

E

V

T

T

L

S

A

I

V

C

C

Q

E

R

R

V

A

I

Y

V

I

L

V

D

S

Q

Q

G

G

A

H

K

L

L

I

V

A

E

H

G

G

L

T

P

P

G

T

D

E

I

I

I

L

Q

Q

D

D

Q

E

R

H

V

V

R

K

E

R

A

V

Y

Y

binding adenosine-5'-diphosphate: Y12 (= Y17), R15 (≠ V20), V17 (≠ A22), G38 (= G43), G40 (= G45), K41 (= K46), T42 (≠ S47), T43 (= T48)
binding (3s,5s,7s)-N-{7-[(3-O-carbamoyl-6-deoxy-5-methyl-4-O-methyl-beta-D-gulopyranosyl)oxy]-4-hydroxy-8-methyl-2-oxo-2H-1-benzopyran-3-yl}tricyclo[3.3.1.1~3,7~]decane-1-carboxamide: F89 (= F95), R90 (= R96), R91 (≠ S97)

1ji0A Crystal structure analysis of the abc transporter from thermotoga maritima
31% identity, 97% coverage: 7:256/257 of query aligns to 6:238/240 of 1ji0A

query
sites
1ji0A

L

V

L

L

E

E

I

V

K

Q

N

S

L

L

S

H

K

V

S

Y

Y
|
Y

G

G

A

A

V

I

K

H

A

A

V

I

N

K

D

G

V

I

S

D

I

L

H

K

I

V

D

P

R

R

G

G

E

Q

I

I

A

V

G

T

L

L

I

I

G

G

P

A

N

N

G
|
G

S

A

G
|
G

K
|
K

S
x
T

T
|
T

F

T

F

L

D

S

C

A

S

I

T

A

G

G

L

L

A

V

K

R

P

A

D

Q

T

K

G

G

T

K

V

I

V

I

L

F

D

N

G

G

Q

Q

D

D

I

I

T

T

G

N

W

K

S

P

L

A

N

H

R

V

I

I

A

N

R

R

E

M

G

G

R

I

M

A

L

L

R

V

S

P

F
x
E

Q

G

K

R

T

R

V

I

T

-

F

F

R

P

S

E

L

L

D

T

V

V

E

Y

E

E

N

N

L

L

V

M

I

-

A

-

G

-

Q

-

M

-

F

-

T

-

F

-

P

-

S

-

I

-

T

-

S

-

T

-

F

-

G

-

L

M

G

G

K

A

M

Y

S

N

R

R

Q

K

R

D

V

K

G

E

G

G

L

I

R

K

E

-

R

-

A

-

R

R

D

D

L

L

I

E

K

W

M

I

A

F

G

S

L

L

W

F

-

P

-

R

-

L

-

K

D

E

V

R

R

L

H

K

Q

Q

P

L

A

G

G

G

N

T

L

L

S

S

G

G

G

G

Q

E

Q

Q

K

Q

L

M

I

L

Q

A

F

I

A

G

S

R

M

A

L

L

M

M

P

S

E

R

P

P

K

K

L

L

I

L

L

M

L

M

D

D

E
|
E

P

P

M

S

A

L

G

G

I

L

N

A

P

P

K

I

I

L

I

V

E

S

R

E

V

V

V

F

D

E

T

V

I

I

R

Q

Y

K

A

I

N

N

K

Q

S

E

L

-

G

G

V

T

S

T

F

I

L

L

V

L

I

V

E

E

H

Q

N

N

I

A

D

L

V

G

V

A

T

L

S

K

I

V

C

A

Q

H

R

Y

V

G

I

Y

V

V

L

L

D

E

Q

T

G

G

A

Q

K

I

L

V

V

L

E

E

G

G

L

K

P

A

G

S

D

E

I

L

I

L

Q

D

D

N

Q

E

R

M

V

V

R

R

E

K

A

A

Y

Y

L

L

G

G

binding adenosine-5'-triphosphate: Y16 (= Y17), G42 (= G43), G44 (= G45), K45 (= K46), T46 (≠ S47), T47 (= T48), E88 (≠ F89), E165 (= E182)

3c4jA Abc protein artp in complex with atp-gamma-s
30% identity, 98% coverage: 5:255/257 of query aligns to 1:238/242 of 3c4jA

query
sites
3c4jA

L

L

P

Q

L

M

L

I

E

D

I

V

K

H

N

Q

L

L

S

K

K

K

S

S

Y
x
F

G

G

A

S

V

L

K

E

A
x
V

V

L

N

K

D

G

V

I

S

N

I

V

H

H

I

I

D

R

R

E

G

G

E

E

I

V

A

V

G

V

L

V

I

I

G

G

P

P

N
x
S

G
|
G

S
|
S

G
|
G

K
|
K

S
|
S

T
|
T

F

F

F

L

D

R

C

C

S

L

T

N

G

L

L

L

A

E

K

D

P

F

D

D

T

E

G

G

T

E

V

I

V

I

L

I

D

D

G

G

Q

I

D

N

I

L

T

K

G

A

-

K

-

D

W

T

S

N

L

L

N

N

R

K

I

V

A

R

R

E

E

E

G

V

R

G

M

M

L

V

R

-

S

-

F

F

Q

Q

K

R

T

F

V

N

T

L

F

F

R

P

S

H

L

M

D

T

V

V

E

L

E

N

N

N

L

I

V

T

I

L

A

A

G

-

Q

-

M

-

F

-

T

-

F

-

P

-

S

-

I

-

T

-

S

-

T

P

F

M

G

K

L

V

G

R

K

K

M

W

S

P

R

R

Q

E

R

K

V

A

G

E

G

A

L

-

R

-

E

-

R

K

A

A

R

M

D

E

L

L

I

L

K

D

M

K

A

V

G

G

L

L

W

K

D

D

V

K

R

A

H

H

Q

A

P

Y

A

P

G

D

N

S

L

L

S

S

G

G

G

G

Q

Q

Q

A

K

Q

L

R

I

V

Q

A

F

I

A

A

S

R

M

A

L

L

M

A

P

M

E

E

P

P

K

K

L

I

I

M

L

L

L

F

D

D

E

E

P

P

M

T

A

S

G

A

I

L

N

D

P

P

K

E

I

M

I

V

E

G

R

E

V

V

V

L

D

S

T

V

I

M

R

K

-

Q

Y

L

A

A

N

N

K

E

S

-

L

-

G

G

V

M

S

T

F

M

L

V

V

V

I

V

E

T

H

H

N

E

I

M

D

G

V

F

V

A

T

R

S

E

I

V

C

G

Q

D

R

R

V

V

I

L

V

F

L

M

D

D

Q

G

G

G

A

Y

K

I

L

I

V

E

E

E

G

G

L

K

P

P

G

E

D

D

I

L

I

F

-

D

-

R

-

P

Q

Q

D

H

Q

E

R

R

V

T

R

K

E

-

A

A

Y

F

L

L

binding phosphothiophosphoric acid-adenylate ester: F13 (≠ Y17), V18 (≠ A22), S38 (≠ N42), G39 (= G43), S40 (= S44), G41 (= G45), K42 (= K46), S43 (= S47), T44 (= T48)

3c41J Abc protein artp in complex with amp-pnp/mg2+
30% identity, 98% coverage: 5:255/257 of query aligns to 1:238/242 of 3c41J

query
sites
3c41J

L

L

P

Q

L

M

L

I

E

D

I

V

K

H

N

Q

L

L

S

K

K

K

S

S

Y
x
F

G

G

A

S

V

L

K

E

A
x
V

V

L

N

K

D

G

V

I

S

N

I

V

H

H

I

I

D

R

R

E

G

G

E

E

I

V

A

V

G

V

L

V

I

I

G

G

P

P

N
x
S

G
|
G

S

S

G
|
G

K
|
K

S
|
S

T
|
T

F

F

F

L

D

R

C

C

S

L

T

N

G

L

L

L

A

E

K

D

P

F

D

D

T

E

G

G

T

E

V

I

V

I

L

I

D

D

G

G

Q

I

D

N

I

L

T

K

G

A

-

K

-

D

W

T

S

N

L

L

N

N

R

K

I

V

A

R

R

E

E

E

G

V

R

G

M

M

L

V

R

-

S

-

F

F

Q

Q

K

R

T

F

V

N

T

L

F

F

R

P

S

H

L

M

D

T

V

V

E

L

E

N

N

N

L

I

V

T

I

L

A

A

G

-

Q

-

M

-

F

-

T

-

F

-

P

-

S

-

I

-

T

-

S

-

T

P

F

M

G

K

L

V

G

R

K

K

M

W

S

P

R

R

Q

E

R

K

V

A

G

E

G

A

L

-

R

-

E

-

R

K

A

A

R

M

D

E

L

L

I

L

K

D

M

K

A

V

G

G

L

L

W

K

D

D

V

K

R

A

H

H

Q

A

P

Y

A

P

G

D

N

S

L

L

S

S

G

G

G

G

Q

Q

Q

A

K

Q

L

R

I

V

Q

A

F

I

A

A

S

R

M

A

L

L

M

A

P

M

E

E

P

P

K

K

L

I

I

M

L

L

L

F

D
|
D

E

E

P

P

M

T

A

S

G

A

I

L

N

D

P

P

K

E

I

M

I

V

E

G

R

E

V

V

V

L

D

S

T

V

I

M

R

K

-

Q

Y

L

A

A

N

N

K

E

S

-

L

-

G

G

V

M

S

T

F

M

L

V

V

V

I

V

E

T

H

H

N

E

I

M

D

G

V

F

V

A

T

R

S

E

I

V

C

G

Q

D

R

R

V

V

I

L

V

F

L

M

D

D

Q

G

G

G

A

Y

K

I

L

I

V

E

E

E

G

G

L

K

P

P

G

E

D

D

I

L

I

F

-

D

-

R

-

P

Q

Q

D

H

Q

E

R

R

V

T

R

K

E

-

A

A

Y

F

L

L

binding phosphoaminophosphonic acid-adenylate ester: F13 (≠ Y17), V18 (≠ A22), S38 (≠ N42), G39 (= G43), G41 (= G45), K42 (= K46), S43 (= S47), T44 (= T48)
binding magnesium ion: S43 (= S47), D163 (= D181)

2olkA Abc protein artp in complex with adp-beta-s
30% identity, 98% coverage: 5:255/257 of query aligns to 1:238/242 of 2olkA

query
sites
2olkA

L

L

P

Q

L

M

L

I

E

D

I

V

K

H

N

Q

L

L

S

K

K

K

S

S

Y
x
F

G

G

A

S

V

L

K

E

A
x
V

V

L

N

K

D

G

V

I

S

N

I

V

H

H

I

I

D

R

R

E

G

G

E

E

I

V

A

V

G

V

L

V

I

I

G

G

P

P

N
x
S

G
|
G

S
|
S

G
|
G

K
|
K

S
|
S

T
|
T

F

F

F

L

D

R

C

C

S

L

T

N

G

L

L

L

A

E

K

D

P

F

D

D

T

E

G

G

T

E

V

I

V

I

L

I

D

D

G

G

Q

I

D

N

I

L

T

K

G

A

-

K

-

D

W

T

S

N

L

L

N

N

R

K

I

V

A

R

R

E

E

E

G

V

R

G

M

M

L

V

R

-

S

-

F

F

Q

Q

K

R

T

F

V

N

T

L

F

F

R

P

S

H

L

M

D

T

V

V

E

L

E

N

N

N

L

I

V

T

I

L

A

A

G

-

Q

-

M

-

F

-

T

-

F

-

P

-

S

-

I

-

T

-

S

-

T

P

F

M

G

K

L

V

G

R

K

K

M

W

S

P

R

R

Q

E

R

K

V

A

G

E

G

A

L

-

R

-

E

-

R

K

A

A

R

M

D

E

L

L

I

L

K

D

M

K

A

V

G

G

L

L

W

K

D

D

V

K

R

A

H

H

Q

A

P

Y

A

P

G

D

N

S

L

L

S

S

G

G

G

G

Q

Q

Q

A

K

Q

L

R

I

V

Q

A

F

I

A

A

S

R

M

A

L

L

M

A

P

M

E

E

P

P

K

K

L

I

I

M

L

L

L

F

D

D

E

E

P

P

M

T

A

S

G

A

I

L

N

D

P

P

K

E

I

M

I

V

E

G

R

E

V

V

V

L

D

S

T

V

I

M

R

K

-

Q

Y

L

A

A

N

N

K

E

S

-

L

-

G

G

V

M

S

T

F

M

L

V

V

V

I

V

E

T

H

H

N

E

I

M

D

G

V

F

V

A

T

R

S

E

I

V

C

G

Q

D

R

R

V

V

I

L

V

F

L

M

D

D

Q

G

G

G

A

Y

K

I

L

I

V

E

E

E

G

G

L

K

P

P

G

E

D

D

I

L

I

F

-

D

-

R

-

P

Q

Q

D

H

Q

E

R

R

V

T

R

K

E

-

A

A

Y

F

L

L

binding 5'-o-[(r)-hydroxy(thiophosphonooxy)phosphoryl]adenosine: F13 (≠ Y17), V18 (≠ A22), S38 (≠ N42), G39 (= G43), S40 (= S44), G41 (= G45), K42 (= K46), S43 (= S47), T44 (= T48)

2oljA Abc protein artp in complex with adp/mg2+
30% identity, 98% coverage: 5:255/257 of query aligns to 1:238/242 of 2oljA

query
sites
2oljA

L

L

P

Q

L

M

L

I

E

D

I

V

K

H

N

Q

L

L

S

K

K

K

S

S

Y
x
F

G

G

A

S

V

L

K

E

A
x
V

V

L

N

K

D

G

V

I

S

N

I

V

H

H

I

I

D

R

R

E

G

G

E

E

I

V

A

V

G

V

L

V

I

I

G

G

P

P

N
x
S

G
|
G

S
|
S

G
|
G

K
|
K

S
|
S

T
|
T

F

F

F

L

D

R

C

C

S

L

T

N

G

L

L

L

A

E

K

D

P

F

D

D

T

E

G

G

T

E

V

I

V

I

L

I

D

D

G

G

Q

I

D

N

I

L

T

K

G

A

-

K

-

D

W

T

S

N

L

L

N

N

R

K

I

V

A

R

R

E

E

E

G

V

R

G

M

M

L

V

R

-

S

-

F

F

Q

Q

K

R

T

F

V

N

T

L

F

F

R

P

S

H

L

M

D

T

V

V

E

L

E

N

N

N

L

I

V

T

I

L

A

A

G

-

Q

-

M

-

F

-

T

-

F

-

P

-

S

-

I

-

T

-

S

-

T

P

F

M

G

K

L

V

G

R

K

K

M

W

S

P

R

R

Q

E

R

K

V

A

G

E

G

A

L

-

R

-

E

-

R

K

A

A

R

M

D

E

L

L

I

L

K

D

M

K

A

V

G

G

L

L

W

K

D

D

V

K

R

A

H

H

Q

A

P

Y

A

P

G

D

N

S

L

L

S

S

G

G

G

G

Q

Q

Q

A

K

Q

L

R

I

V

Q

A

F

I

A

A

S

R

M

A

L

L

M

A

P

M

E

E

P

P

K

K

L

I

I

M

L

L

L

F

D

D

E

E

P

P

M

T

A

S

G

A

I

L

N

D

P

P

K

E

I

M

I

V

E

G

R

E

V

V

V

L

D

S

T

V

I

M

R

K

-

Q

Y

L

A

A

N

N

K

E

S

-

L

-

G

G

V

M

S

T

F

M

L

V

V

V

I

V

E

T

H

H

N

E

I

M

D

G

V

F

V

A

T

R

S

E

I

V

C

G

Q

D

R

R

V

V

I

L

V

F

L

M

D

D

Q

G

G

G

A

Y

K

I

L

I

V

E

E

E

G

G

L

K

P

P

G

E

D

D

I

L

I

F

-

D

-

R

-

P

Q

Q

D

H

Q

E

R

R

V

T

R

K

E

-

A

A

Y

F

L

L

binding adenosine-5'-diphosphate: F13 (≠ Y17), V18 (≠ A22), S38 (≠ N42), G39 (= G43), S40 (= S44), G41 (= G45), K42 (= K46), S43 (= S47), T44 (= T48)

P30750 Methionine import ATP-binding protein MetN; EC 7.4.2.11 from Escherichia coli (strain K12) (see 3 papers)
29% identity, 90% coverage: 7:238/257 of query aligns to 1:221/343 of P30750

query
sites
P30750

L

M

L

I

E

K

I

L

K

S

N

N

L

I

S

T

K

K

S

V

Y

F

G

H

-

Q

-

G

-

T

-

R

A

T

V

I

K

Q

A

A

V

L

N

N

D

N

V

V

S

S

I

L

H

H

I

V

D

P

R

A

G

G

E

Q

I

I

A

Y

G

G

L

V

I

I

G

G

P

A

N
x
S

G
|
G

S
x
A

G
|
G

K
|
K

S
|
S

T
|
T

F

L

F

I

D

R

C

C

S

V

T

N

G

L

L

L

A

E

K

R

P

P

D

T

T

E

G

G

T

S

V

V

V

L

L

V

D

D

G

G

Q

Q

D

E

I

L

T

T

G

T

W

L

S

S

L

E

N

S

R

E

I

L

A

T

R

K

E

A

G

R

R

R

M

Q

L

I

-

G

R

M

S

I

F

F

Q

Q

K

H

T

F

V

N

T

L

F

L

R

S

S

S

L

R

D

T

V

V

E

F

E

G

N

N

L

V

V

A

I

L

A

P

G

L

Q

E

M

L

F

D

T

N

F

T

P

P

S

K

I

-

T

-

S

-

T

-

F

-

G

-

L

-

G

-

K

-

M

-

S

-

R

-

Q

-

R

-

V

-

G

D

G

E

L

V

R

K

E

R

R

R

A

V

R

T

D

E

L

L

I

L

K

S

M

L

A

V

G

G

L

L

W

G

D

D

V

K

R

H

H

D

Q

S

P

Y

A

P

G

S

N

N

L

L

S

S

G

G

G

G

Q

Q

Q

K

K

Q

L

R

I

V

Q

A

F

I

A

A

S

R

M

A

L

L

M

A

P

S

E

N

P

P

K

K

L

V

I

L

L

L

L

C

D

D

E
|
E

P

A

M

T

A

S

G

A

I

L

N

D

P

P

K

A

I

T

I

T

E

R

R

S

V

I

V

L

D

E

T

L

I

L

R

K

Y

D

A

I

N

N

K

R

S

R

L

L

G

G

V

L

S

T

F

I

L

L

V

L

I

I

E

T

H

H

N

E

I

M

D

D

V

V

V

V

T

K

S

R

I

I

C

C

Q

D

R

C

V

V

I

A

V

V

L

I

D

S

Q

N

G

G

A

-

K

E

L

L

V

I

E

E

40:46 (vs. 42:48, 71% identical) binding ATP
E166 (= E182) mutation to Q: Exhibits little ATPase activity.

Sites not aligning to the query:

278:283 binding L-methionine
295 N→A: Reduces the binding of L-methionine to undetectable levels.
295:296 binding L-methionine

3tuzC Inward facing conformations of the metni methionine abc transporter: cy5 semet soak crystal form (see paper)
29% identity, 90% coverage: 7:238/257 of query aligns to 2:222/344 of 3tuzC

query
sites
3tuzC

L

M

L

I

E

K

I

L

K

S

N

N

L

I

S

T

K

K

S

V

Y
x
F

G

H

-
x
Q

-

G

-

T

-

R

A

T

V

I

K

Q

A

A

V

L

N

N

D

N

V

V

S

S

I

L

H

H

I

V

D

P

R

A

G

G

E

Q

I

I

A

Y

G

G

L

V

I

I

G

G

P

A

N

S

G
|
G

S

A

G
|
G

K
|
K

S
|
S

T
|
T

F

L

F

I

D

R

C

C

S

V

T

N

G

L

L

L

A

E

K

R

P

P

D

T

T

E

G

G

T

S

V

V

V

L

L

V

D

D

G

G

Q

Q

D

E

I

L

T

T

G

T

W

L

S

S

L

E

N

S

R

E

I

L

A

T

R

K

E

A

G

R

R

R

M

Q

L

I

-

G

R

M

S

I

F

F

Q

Q

K

H

T

F

V

N

T

L

F

L

R

S

S

S

L

R

D

T

V

V

E

F

E

G

N

N

L

V

V

A

I

L

A

P

G

L

Q

E

M

L

F

D

T

N

F

T

P

P

S

K

I

-

T

-

S

-

T

-

F

-

G

-

L

-

G

-

K

-

M

-

S

-

R

-

Q

-

R

-

V

-

G

D

G

E

L

V

R

K

E

R

R

R

A

V

R

T

D

E

L

L

I

L

K

S

M

L

A

V

G

G

L

L

W

G

D

D

V

K

R

H

H

D

Q

S

P

Y

A

P

G

S

N

N

L

L

S

S

G

G

G

G

Q

Q

Q

K

K

Q

L

R

I

V

Q

A

F

I

A

A

S

R

M

A

L

L

M

A

P

S

E

N

P

P

K

K

L

V

I

L

L

L

L

C

D

D

E

Q

P

A

M

T

A

S

G

A

I

L

N

D

P

P

K

A

I

T

I

T

E

R

R

S

V

I

V

L

D

E

T

L

I

L

R

K

Y

D

A

I

N

N

K

R

S

R

L

L

G

G

V

L

S

T

F

I

L

L

V

L

I

I

E

T

H

H

N

E

I

M

D

D

V

V

V

V

T

K

S

R

I

I

C

C

Q

D

R

C

V

V

I

A

V

V

L

I

D

S

Q

N

G

G

A

-

K

E

L

L

V

I

E

E

binding adenosine-5'-diphosphate: F12 (≠ Y17), Q14 (vs. gap), G42 (= G43), G44 (= G45), K45 (= K46), S46 (= S47), T47 (= T48)

Sites not aligning to the query:

binding selenomethionine: 274, 279, 281, 282, 283, 284, 311, 313

3tuiC Inward facing conformations of the metni methionine abc transporter: cy5 native crystal form (see paper)
29% identity, 90% coverage: 7:238/257 of query aligns to 2:222/344 of 3tuiC

query
sites
3tuiC

L

M

L

I

E

K

I

L

K

S

N

N

L

I

S

T

K

K

S

V

Y
x
F

G

H

-

Q

-

G

-

T

-

R

A

T

V

I

K

Q

A

A

V

L

N

N

D

N

V

V

S

S

I

L

H

H

I

V

D

P

R

A

G

G

E

Q

I

I

A

Y

G

G

L

V

I

I

G

G

P

A

N

S

G
|
G

S
x
A

G
|
G

K
|
K

S
|
S

T
|
T

F

L

F

I

D

R

C

C

S

V

T

N

G

L

L

L

A

E

K

R

P

P

D

T

T

E

G

G

T

S

V

V

V

L

L

V

D

D

G

G

Q

Q

D

E

I

L

T

T

G

T

W

L

S

S

L

E

N

S

R

E

I

L

A

T

R

K

E

A

G

R

R

R

M

Q

L

I

-

G

R

M

S

I

F

F

Q

Q

K

H

T

F

V

N

T

L

F

L

R

S

S

S

L

R

D

T

V

V

E

F

E

G

N

N

L

V

V

A

I

L

A

P

G

L

Q

E

M

L

F

D

T

N

F

T

P

P

S

K

I

-

T

-

S

-

T

-

F

-

G

-

L

-

G

-

K

-

M

-

S

-

R

-

Q

-

R

-

V

-

G

D

G

E

L

V

R

K

E

R

R

R

A

V

R

T

D

E

L

L

I

L

K

S

M

L

A

V

G

G

L

L

W

G

D

D

V

K

R

H

H

D

Q

S

P

Y

A

P

G

S

N

N

L

L

S

S

G

G

G

G

Q

Q

Q

K

K

Q

L

R

I

V

Q

A

F

I

A

A

S

R

M

A

L

L

M

A

P

S

E

N

P

P

K

K

L

V

I

L

L

L

L

C

D

D

E

Q

P

A

M

T

A

S

G

A

I

L

N

D

P

P

K

A

I

T

I

T

E

R

R

S

V

I

V

L

D

E

T

L

I

L

R

K

Y

D

A

I

N

N

K

R

S

R

L

L

G

G

V

L

S

T

F

I

L

L

V

L

I

I

E

T

H

H

N

E

I

M

D

D

V

V

V

V

T

K

S

R

I

I

C

C

Q

D

R

C

V

V

I

A

V

V

L

I

D

S

Q

N

G

G

A

-

K

E

L

L

V

I

E

E

binding adenosine-5'-diphosphate: F12 (≠ Y17), G42 (= G43), A43 (≠ S44), G44 (= G45), K45 (= K46), S46 (= S47), T47 (= T48)

6cvlD Crystal structure of the escherichia coli atpgs-bound metni methionine abc transporter in complex with its metq binding protein (see paper)
29% identity, 90% coverage: 7:238/257 of query aligns to 2:222/344 of 6cvlD

query
sites
6cvlD

L

M

L

I

E

K

I

L

K

S

N

N

L

I

S

T

K

K

S

V

Y
x
F

G

H

-
x
Q

-

G

-

T

-

R

A

T

V
x
I

K

Q

A

A

V

L

N

N

D

N

V

V

S

S

I

L

H

H

I

V

D

P

R

A

G

G

E

Q

I

I

A

Y

G

G

L

V

I

I

G

G

P

A

N
x
S

G
|
G

S
x
A

G
|
G

K
|
K

S
|
S

T
|
T

F

L

F

I

D

R

C

C

S

V

T

N

G

L

L

L

A

E

K

R

P

P

D

T

T

E

G

G

T

S

V

V

V

L

L

V

D

D

G

G

Q

Q

D

E

I

L

T

T

G

T

W

L

S

S

L

E

N

S

R

E

I

L

A

T

R

K

E

A

G

R

R

R

M

Q

L

I

-

G

R

M

S

I

F

F

Q

Q

K

H

T

F

V

N

T

L

F

L

R

S

S

S

L

R

D

T

V

V

E

F

E

G

N

N

L

V

V

A

I

L

A

P

G

L

Q

E

M

L

F

D

T

N

F

T

P

P

S

K

I

-

T

-

S

-

T

-

F

-

G

-

L

-

G

-

K

-

M

-

S

-

R

-

Q

-

R

-

V

-

G

D

G

E

L

V

R

K

E

R

R

R

A

V

R

T

D

E

L

L

I

L

K

S

M

L

A

V

G

G

L

L

W

G

D

D

V

K

R

H

H

D

Q

S

P

Y

A

P

G

S

N
|
N

L

L

S
|
S

G

G

G

G

Q
|
Q

Q

K

K

Q

L

R

I

V

Q

A

F

I

A

A

S

R

M

A

L

L

M

A

P

S

E

N

P

P

K

K

L

V

I

L

L

L

L

C

D

D

E

Q

P

A

M

T

A

S

G

A

I

L

N

D

P

P

K

A

I

T

I

T

E

R

R

S

V

I

V

L

D

E

T

L

I

L

R

K

Y

D

A

I

N

N

K

R

S

R

L

L

G

G

V

L

S

T

F

I

L

L

V

L

I

I

E

T

H
|
H

N

E

I

M

D

D

V

V

V

V

T

K

S

R

I

I

C

C

Q

D

R

C

V

V

I

A

V

V

L

I

D

S

Q

N

G

G

A

-

K

E

L

L

V

I

E

E

binding phosphothiophosphoric acid-adenylate ester: F12 (≠ Y17), Q14 (vs. gap), I19 (≠ V20), S41 (≠ N42), G42 (= G43), A43 (≠ S44), G44 (= G45), K45 (= K46), S46 (= S47), T47 (= T48), N141 (= N156), S143 (= S158), Q146 (= Q161), H200 (= H215)

4ymuJ Crystal structure of an amino acid abc transporter complex with arginines and atps (see paper)
29% identity, 95% coverage: 10:252/257 of query aligns to 4:234/240 of 4ymuJ

query
sites
4ymuJ

I

V

K

N

N

D

L

V

S

Y

K

K

S

N

Y
x
F

G

G

A

S

V

L

K

E

A
x
V

V

L

N

K

D

G

V

V

S

T

I

L

H

K

I

V

D

N

R

K

G

G

E

E

I

V

A

V

G

V

L

I

I

I

G

G

P

P

N
x
S

G
|
G

S
|
S

G
|
G

K
|
K

S
|
S

T
|
T

F

L

F

L

D

R

C

C

S

I

T

N

G

L

L

L

A

E

K

E

P

P

D

T

T

K

G

G

T

E

V

V

V

F

L

I

D

D

G

G

Q

V

D

K

I

I

T

N

G

N

W

G

S

K

L

V

N

N

R

I

I

N

A

K

R

V

E

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N

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|
E

P

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G

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C

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E

binding adenosine-5'-triphosphate: F11 (≠ Y17), V16 (≠ A22), S36 (≠ N42), G37 (= G43), S38 (= S44), G39 (= G45), K40 (= K46), S41 (= S47), T42 (= T48), E162 (= E182), H194 (= H215)
binding magnesium ion: S41 (= S47), E162 (= E182)

Query Sequence

>WP_011649173.1 NCBI__GCF_000009265.1:WP_011649173.1
MTSHLPLLEIKNLSKSYGAVKAVNDVSIHIDRGEIAGLIGPNGSGKSTFFDCSTGLAKPD
TGTVVLDGQDITGWSLNRIAREGRMLRSFQKTVTFRSLDVEENLVIAGQMFTFPSITSTF
GLGKMSRQRVGGLRERARDLIKMAGLWDVRHQPAGNLSGGQQKLIQFASMLMPEPKLILL
DEPMAGINPKIIERVVDTIRYANKSLGVSFLVIEHNIDVVTSICQRVIVLDQGAKLVEGL
PGDIIQDQRVREAYLGG

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory