SitesBLAST
Comparing WP_011651407.1 NCBI__GCF_000009265.1:WP_011651407.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
4za2D Crystal structure of pectobacterium carotovorum 2-keto-3-deoxy-d- gluconate dehydrogenase complexed with NAD+ (see paper)
39% identity, 95% coverage: 10:253/256 of query aligns to 5:244/247 of 4za2D
- binding nicotinamide-adenine-dinucleotide: G17 (= G22), D19 (≠ A24), L22 (≠ I27), I42 (≠ D46), D65 (= D69), M66 (≠ V70), N92 (≠ S96), A93 (= A97), G94 (= G98), L115 (≠ I119), I143 (= I147), S145 (= S149), Y158 (= Y162), K162 (= K166), G189 (≠ T193), M191 (≠ V195), T193 (= T197), N195 (≠ L199)
3op4A Crystal structure of putative 3-ketoacyl-(acyl-carrier-protein) reductase from vibrio cholerae o1 biovar eltor str. N16961 in complex with NADP+ (see paper)
40% identity, 96% coverage: 11:256/256 of query aligns to 4:247/247 of 3op4A
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G15 (= G22), S17 (≠ A24), R18 (≠ S25), I20 (= I27), T40 (≠ I47), N62 (≠ D69), V63 (= V70), N89 (≠ S96), A90 (= A97), I92 (≠ V99), V139 (≠ I147), S141 (= S149), Y154 (= Y162), K158 (= K166), P184 (= P192), G185 (≠ T193), I187 (≠ V195), T189 (= T197), M191 (≠ L199)
6t77A Crystal structure of klebsiella pneumoniae fabg(NADPH-dependent) NADP- complex at 1.75 a resolution (see paper)
40% identity, 96% coverage: 11:256/256 of query aligns to 1:244/244 of 6t77A
- active site: G16 (= G26), S138 (= S149), Y151 (= Y162)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G12 (= G22), S14 (≠ A24), R15 (≠ S25), T37 (≠ I47), L58 (≠ C68), N59 (≠ D69), V60 (= V70), A87 (= A97), G88 (= G98), I89 (≠ V99)
4wecA Crystal structure of a short chain dehydrogenase from mycobacterium smegmatis
43% identity, 96% coverage: 7:252/256 of query aligns to 2:249/258 of 4wecA
- active site: G21 (= G26), S143 (= S149), Q154 (≠ H159), Y157 (= Y162), K161 (= K166)
- binding nicotinamide-adenine-dinucleotide: G17 (= G22), A19 (= A24), S20 (= S25), G21 (= G26), I22 (= I27), D41 (= D46), I42 (= I47), V61 (≠ C68), D62 (= D69), V63 (= V70), N89 (≠ S96), T141 (≠ I147), Y157 (= Y162), K161 (= K166), P187 (= P192), P189 (≠ V194), V190 (= V195)
P0AEK2 3-oxoacyl-[acyl-carrier-protein] reductase FabG; 3-ketoacyl-acyl carrier protein reductase; Beta-Ketoacyl-acyl carrier protein reductase; Beta-ketoacyl-ACP reductase; EC 1.1.1.100 from Escherichia coli (strain K12) (see 2 papers)
40% identity, 97% coverage: 9:256/256 of query aligns to 1:244/244 of P0AEK2
- GASR 12:15 (≠ GGAS 22:25) binding NADP(+)
- T37 (≠ I47) binding NADP(+)
- NV 59:60 (≠ DV 69:70) binding NADP(+)
- N86 (≠ S96) binding NADP(+)
- Y151 (= Y162) mutation to F: Defect in the affinity for NADPH.
- YAAAK 151:155 (≠ YCASK 162:166) binding NADP(+)
- A154 (≠ S165) mutation to T: Decreases in the thermolability of the reductase; when associated with K-233.
- K155 (= K166) mutation to A: Defect in the affinity for NADPH.
- I184 (≠ V195) binding NADP(+)
- E233 (≠ A245) mutation to K: Decreases in the thermolability of the reductase; when associated with T-154.
1q7bA The structure of betaketoacyl-[acp] reductase from e. Coli in complex with NADP+ (see paper)
40% identity, 96% coverage: 10:256/256 of query aligns to 1:243/243 of 1q7bA
- active site: G15 (= G26), E101 (≠ A112), S137 (= S149), Q147 (≠ H159), Y150 (= Y162), K154 (= K166)
- binding calcium ion: E232 (≠ A245), T233 (≠ D246)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G11 (= G22), S13 (≠ A24), R14 (≠ S25), T36 (≠ I47), N58 (≠ D69), V59 (= V70), N85 (≠ S96), A86 (= A97), G87 (= G98), I88 (≠ V99), S137 (= S149), Y150 (= Y162), K154 (= K166), P180 (= P192), G181 (≠ T193), I183 (≠ V195)
4i08A Crystal structure of beta-ketoacyl-acyl carrier protein reductase (fabg) from vibrio cholerae in complex with NADPH (see paper)
40% identity, 96% coverage: 11:256/256 of query aligns to 4:243/243 of 4i08A
- active site: G19 (= G26), N113 (= N120), S141 (= S149), Q151 (≠ H159), Y154 (= Y162), K158 (= K166)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: G15 (= G22), S17 (≠ A24), R18 (≠ S25), I20 (= I27), T40 (≠ I47), N62 (≠ D69), V63 (= V70), N89 (≠ S96), A90 (= A97), G140 (≠ A148), S141 (= S149), Y154 (= Y162), K158 (= K166), P184 (= P192), G185 (≠ T193), T189 (= T197)
P0A2C9 3-oxoacyl-[acyl-carrier-protein] reductase FabG; 3-ketoacyl-acyl carrier protein reductase; Beta-Ketoacyl-acyl carrier protein reductase; Beta-ketoacyl-ACP reductase; EC 1.1.1.100 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see paper)
40% identity, 96% coverage: 11:256/256 of query aligns to 1:244/244 of P0A2C9
- M125 (= M135) mutation to I: Loss of the temperature-sensitive phenotype; when associated with T-223.
- A223 (= A235) mutation to T: Loss of the temperature-sensitive phenotype; when associated with I-125.
- S224 (= S236) mutation to F: Distorts the local conformation and prevent stacking around Phe-221. The S224F mutation would additionally disrupt the hydrogen bond formed between Ser-224 and Glu-226.
1vl8B Crystal structure of gluconate 5-dehydrogenase (tm0441) from thermotoga maritima at 2.07 a resolution
39% identity, 95% coverage: 11:254/256 of query aligns to 2:250/252 of 1vl8B
- active site: G17 (= G26), S143 (= S149), I154 (≠ H159), Y157 (= Y162), K161 (= K166)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G13 (= G22), R16 (≠ S25), G17 (= G26), L18 (≠ I27), S37 (≠ D46), R38 (≠ I47), C63 (= C68), D64 (= D69), V65 (= V70), A91 (≠ S96), A92 (= A97), G93 (= G98), I94 (≠ V99), V114 (≠ I119), I141 (= I147), S143 (= S149), Y157 (= Y162), K161 (= K166), P187 (= P192), G188 (≠ T193), Y190 (≠ V195), T192 (= T197), M194 (≠ L199), T195 (≠ G200)
1q7cA The structure of betaketoacyl-[acp] reductase y151f mutant in complex with NADPH fragment (see paper)
40% identity, 96% coverage: 10:256/256 of query aligns to 1:243/243 of 1q7cA
- active site: G15 (= G26), S137 (= S149), Q147 (≠ H159), F150 (≠ Y162), K154 (= K166)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: G11 (= G22), S13 (≠ A24), R14 (≠ S25), A35 (≠ D46), T36 (≠ I47), L57 (≠ C68), N58 (≠ D69), V59 (= V70), G87 (= G98), I88 (≠ V99)
5itvA Crystal structure of bacillus subtilis bacc dihydroanticapsin 7- dehydrogenase in complex with nadh (see paper)
38% identity, 95% coverage: 11:254/256 of query aligns to 3:253/255 of 5itvA
- active site: G18 (= G26), S141 (= S149), Y154 (= Y162), K158 (= K166)
- binding 1,4-dihydronicotinamide adenine dinucleotide: G14 (= G22), S17 (= S25), G18 (= G26), I19 (= I27), D38 (= D46), I39 (= I47), T61 (≠ C68), I63 (≠ V70), N89 (≠ S96), G91 (= G98), T139 (≠ I147), S141 (= S149), Y154 (= Y162), K158 (= K166), P184 (= P192), G185 (≠ T193), I186 (≠ V194), I187 (≠ V195)
3rwbA Crystal structure of complex of 4pal (4-pyridoxolactone) and pldh (tetrameric pyridoxal 4-dehydrogenase) from mesorhizobium loti
43% identity, 94% coverage: 13:252/256 of query aligns to 4:243/247 of 3rwbA
- active site: G17 (= G26), S140 (= S149), Y153 (= Y162), K157 (= K166)
- binding 7-hydroxy-6-methylfuro[3,4-c]pyridin-1(3H)-one: S140 (= S149), N141 (≠ Q150), T142 (≠ A151), M150 (≠ H159), Y153 (= Y162), L185 (≠ V194), H196 (≠ R208)
- binding nicotinamide-adenine-dinucleotide: G13 (= G22), Q16 (≠ S25), G17 (= G26), I18 (= I27), D37 (= D46), I38 (= I47), D60 (= D69), I61 (≠ V70), N87 (≠ S96), A88 (= A97), S89 (≠ G98), I138 (= I147), S140 (= S149), Y153 (= Y162), K157 (= K166), P183 (= P192), L185 (≠ V194), I186 (≠ V195), S188 (≠ T197), G190 (= G200), V191 (≠ R201)
3ndrA Crystal structure of tetrameric pyridoxal 4-dehydrogenase from mesorhizobium loti
43% identity, 94% coverage: 13:252/256 of query aligns to 4:243/247 of 3ndrA
- active site: G17 (= G26), S140 (= S149), Y153 (= Y162), K157 (= K166)
- binding nicotinamide-adenine-dinucleotide: G13 (= G22), Q16 (≠ S25), G17 (= G26), I18 (= I27), D37 (= D46), I38 (= I47), D60 (= D69), I61 (≠ V70), N87 (≠ S96), A88 (= A97), S89 (≠ G98), V110 (≠ I119), I138 (= I147), S140 (= S149), Y153 (= Y162), K157 (= K166), P183 (= P192), L185 (≠ V194), I186 (≠ V195), S188 (≠ T197), G190 (= G200), V191 (≠ R201)
3uf0A Crystal structure of a putative NAD(p) dependent gluconate 5- dehydrogenase from beutenbergia cavernae(efi target efi-502044) with bound NADP (low occupancy)
40% identity, 95% coverage: 11:253/256 of query aligns to 3:246/249 of 3uf0A
- active site: G18 (= G26), S141 (= S149), V151 (≠ H159), Y154 (= Y162), K158 (= K166)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G14 (= G22), S17 (= S25), G18 (= G26), I19 (= I27), R39 (≠ V44), D63 (= D69), L64 (≠ V70), N89 (≠ S96), G91 (= G98), I92 (≠ V99), I139 (= I147), A140 (= A148), S141 (= S149), Y154 (= Y162), K158 (= K166), P184 (= P192), G185 (≠ T193), V187 (= V195), T189 (= T197), N191 (vs. gap), T192 (≠ E198)
6pejA Structure of sorbitol dehydrogenase from sinorhizobium meliloti 1021 bound to sorbitol
39% identity, 94% coverage: 13:252/256 of query aligns to 4:253/257 of 6pejA
7emgB Carbonyl reductase variant 4 (r123c/l209p/f183y/v61k) from serratia marcescens complexed with NADP+ (see paper)
39% identity, 96% coverage: 12:256/256 of query aligns to 1:243/243 of 7emgB
6ixmC Crystal structure of the ketone reductase chkred20 from the genome of chryseobacterium sp. Ca49 complexed with NAD (see paper)
39% identity, 95% coverage: 13:256/256 of query aligns to 3:248/248 of 6ixmC
- active site: G16 (= G26), S142 (= S149), Y155 (= Y162), K159 (= K166)
- binding nicotinamide-adenine-dinucleotide: G12 (= G22), S15 (= S25), G16 (= G26), I17 (= I27), D36 (= D46), I37 (= I47), A61 (≠ C68), D62 (= D69), T63 (≠ V70), N89 (≠ S96), A90 (= A97), M140 (≠ I147), S142 (= S149), Y155 (= Y162), K159 (= K166), P185 (= P192), A186 (≠ T193), Y187 (≠ V194), I188 (≠ V195), L192 (= L199)
3tzcA Crystal structure of 3-ketoacyl-(acyl-carrier-protein) reductase (fabg)(y155f) from vibrio cholerae (see paper)
40% identity, 95% coverage: 11:252/256 of query aligns to 4:222/224 of 3tzcA
3o03A Quaternary complex structure of gluconate 5-dehydrogenase from streptococcus suis type 2 (see paper)
39% identity, 95% coverage: 10:252/256 of query aligns to 6:245/254 of 3o03A
- active site: G22 (= G26), S147 (= S149), V157 (≠ H159), Y160 (= Y162), K164 (= K166)
- binding calcium ion: S147 (= S149), M148 (≠ Q150), P190 (= P192)
- binding D-gluconic acid: I99 (≠ A100), R101 (≠ L102), S147 (= S149), M149 (≠ A151), R154 (≠ I156), Y160 (= Y162)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G18 (= G22), Y21 (≠ S25), G22 (= G26), I23 (= I27), D42 (= D46), I43 (= I47), L47 (≠ T50), D68 (= D69), V69 (= V70), N95 (≠ S96), A96 (= A97), G97 (= G98), I145 (= I147), Y160 (= Y162), K164 (= K166), P190 (= P192)
4jroC Crystal structure of 3-oxoacyl-[acyl-carrier protein]reductase (fabg) from listeria monocytogenes in complex with NADP+
39% identity, 96% coverage: 11:255/256 of query aligns to 1:247/247 of 4jroC
- active site: G16 (= G26), S142 (= S149), Q152 (≠ H159), Y155 (= Y162), K159 (= K166)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G12 (= G22), S14 (≠ A24), R15 (≠ S25), G16 (= G26), I17 (= I27), N35 (vs. gap), Y36 (vs. gap), N37 (vs. gap), G38 (= G43), S39 (≠ V44), N63 (≠ D69), V64 (= V70), N90 (≠ S96), A91 (= A97), I93 (≠ V99), I113 (= I119), S142 (= S149), Y155 (= Y162), K159 (= K166), P185 (= P192), I188 (≠ V195), T190 (= T197)
Query Sequence
>WP_011651407.1 NCBI__GCF_000009265.1:WP_011651407.1
MTDSKQIDLNFSLGGKVALVTGGASGIGDAIASAFAAKGAVVGVIDINETVAKSKADALG
NGAKSFVCDVSNPQSVEAVIAAAQAAFAHIDIVVNSAGVAMLAPAEDLTLEAWDRTIDIN
LKGTFLVSQAVGRVMLKAGKGGRIINIASQAGTVAIDQHVAYCASKFGVIGLSKTLAAEW
GKHGITVNTISPTVVLTELGRKAWDNPRGEELKKRIPTGRFAYPEEIAAAAVFLASSGAE
MINGADLLVDGGYTIV
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory