SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing WP_011652239.1 NCBI__GCF_000009265.1:WP_011652239.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 8 hits to proteins with known functional sites (download)

P14407 Fumarate hydratase class I, anaerobic; D-tartrate dehydratase; Fumarase B; EC 4.2.1.2; EC 4.2.1.81 from Escherichia coli (strain K12) (see paper)
65% identity, 99% coverage: 6:532/535 of query aligns to 12:538/548 of P14407

query
sites
P14407

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K192 (= K186) modified: N6-acetyllysine

6msoA Crystal structure of mitochondrial fumarate hydratase from leishmania major in a complex with inhibitor thiomalate (see paper)
62% identity, 97% coverage: 13:532/535 of query aligns to 17:540/540 of 6msoA

query
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6msoA

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binding (2S)-2-sulfanylbutanedioic acid: Q106 (= Q100), D107 (= D101), R145 (= R139), G188 (= G182), R395 (= R387), T442 (= T434), K465 (= K457)
binding iron/sulfur cluster: C105 (= C99), A223 (= A217), C224 (= C218), C319 (= C312), A321 (= A314), K465 (= K457)

Q4QAU9 Fumarate hydratase 1, mitochondrial; Fumarase 1; LmFH-1; EC 4.2.1.2 from Leishmania major (see paper)
62% identity, 97% coverage: 13:532/535 of query aligns to 26:549/549 of Q4QAU9

query
sites
Q4QAU9

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T

L

M

K

K

T

V

V

L

K

K

L

Y

A

A

S

S

T

C

R

H

Y

Y

L

Y

D

D

E

D

L

L

P

I

T

T

E

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G

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S

D

-

M

E

K

S

T

G

G

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Y

A

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F

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D

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L

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L

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K

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I

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P

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|
C

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A

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D

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K

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M

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V

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M

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L

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N

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C

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K

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G

G

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F

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Y

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L

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P

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L

L

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Q

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A

I

I

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K

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V

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G

M

M

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A

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W

W

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I

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V

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F

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P

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A

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I

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I

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D

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D

K

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E

Q

L

L

C114 (= C99) binding [4Fe-4S] cluster
C233 (= C218) binding [4Fe-4S] cluster
C328 (= C312) binding [4Fe-4S] cluster

E9AE57 Fumarate hydratase 2; Fumarase 2; LmFH-2; EC 4.2.1.2 from Leishmania major (see paper)
61% identity, 97% coverage: 13:531/535 of query aligns to 45:565/568 of E9AE57

query
sites
E9AE57

T

T

P

E

Y

F

R

A

K

K

I

V

S

E

G

G

D

S

H

E

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-

V

-

F

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G

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L

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N

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P

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I

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L

I

L

L

A

A

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H

T

R

A

A

F

F

A

S

D

D

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N

H

H

H

L

F

L

F

R

R

P

K

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D

H

H

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G

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A

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S

R

I

A

L

I

D

E

D

D

P

P

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E

A

A

T

S

D

D

N

N

D

D

R

R

F

Y

V

V

A

A

Y

T

D

T

L

L

L

L

K

K

N

N

A

A

N

C

I

I

A

A

A

A

G

G

G

R

V

V

L

L

P

P

M

S

C
|
C

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|
Q

D
|
D

T

T

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G

T

T

A

A

I

I

I

V

M

L

G

G

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K

K

R

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E

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A

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A

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A

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G

G

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I

M

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D

N

A

A

Y

Y

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K

Y

K

H

N

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L

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R
|
R

Y

Y

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S

Q

Q

L

T

A

A

P

A

V

L

K

D

M

M

F

F

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K

E

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K

C

N

N

T

T

R

G

N

D

N

N

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L

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P

A

A

Q

Q

I

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D

D

I

L

Y

L

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A

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G

P

T

G

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S

A

D

Y

Y

E

E

F

F

L

L

F

F

V

I

A

A

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K

G

G

G

G

G
|
G

S

S

A

A

N
|
N

K
|
K

T
x
A

F
x
Y

L
|
L

Y
|
Y

Q
|
Q

G

E

T

T

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A

L

L

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A

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F

L

I

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E

E

E

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K

I

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L

K

T

T

L

L

G

G

T

T

A

A

A

A

C
|
C

P

P

P

P

Y

Y

H

H

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I

A

A

I

L

V

V

I

I

G

G

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A

A

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M

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M

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K

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I

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L

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|
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A

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K

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G

Y

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A

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F

G

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T
|
T

T
|
T

A
|
A

G
|
G

R
|
R

M

M

D

D

S

S

Y

Y

V

V

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D

Q

L

F

F

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F

H

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G

G

G

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S

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V

I

M

T

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A

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|
K

G

G

N

N

R

R

S

S

R

K

P

Q

V

V

R

T

E

D

A

A

C

C

K

K

K

K

H

H

G

G

G

G

F

F

Y

Y

L

L

G

G

S

S

I

I

G

G

G

G

P

P

A

A

A

A

R

I

L

L

A

A

Q

K

D

D

C

S

I

I

R

K

K

Q

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V

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T

V

C

F

L

E

A

Y

F

P

P

E

E

L

L

G

G

M

M

E

E

A

A

V

V

W

W

K

K

I

I

E

E

V

V

E

E

D

D

F

F

P

P

A

A

F

F

I

I

V

V

I

V

D

D

D

D

K

K

G

G

N

N

D

D

F

M

F

Y

Q

S

E

K

C133 (= C99) binding [4Fe-4S] cluster
QD 134:135 (= QD 100:101) binding (S)-malate
R173 (= R139) binding (S)-malate
G216 (= G182) binding (S)-malate
219:225 (vs. 185:191, 71% identical) binding (S)-malate
C252 (= C218) binding [4Fe-4S] cluster
C346 (= C312) binding [4Fe-4S] cluster
R421 (= R387) binding (S)-malate
TTAGR 467:471 (= TTAGR 433:437) binding (S)-malate
K491 (= K457) binding (S)-malate

6uoiA Crystal structure of cytosolic fumarate hydratase from leishmania major in a complex with malonate (see paper)
60% identity, 97% coverage: 13:531/535 of query aligns to 20:532/535 of 6uoiA

query
sites
6uoiA

T

T

P

E

Y

F

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A

K

K

I

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E

G

G

D

S

H

E

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E

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E

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E

-

V

-

F

G

G

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Q

I

A

L

L

T

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V

E

N

P

P

E

E

G

A

I

L

R

T

L

I

L

L

A

A

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H

T

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A

A

F

F

A

S

D

D

I

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N

H

H

H

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L

F

R

R

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K

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D

H

H

L

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S

R

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A

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D

D

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P

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D

N

N

D

D

R

R

F

Y

V

V

A

A

Y

T

D

T

L

L

L

L

K

K

N

N

A

A

N

C

I

I

A

A

A

A

G

G

G

R

V

V

L

L

P

P

M

S

C
|
C

Q

Q

D

D

T

T

G

G

T

T

A

A

I

I

I

V

M

L

G

G

K

K

K

R

G

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W

W

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T

D

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G

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A

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A

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L

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G

G

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M

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H

N

N

L

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Y

Y

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Q

L

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A

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A

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L

K

D

M

M

F

F

E

K

E

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C

N

N

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T

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G

N

D

N

N

L

L

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P

A

A

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Q

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D

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Y

L

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F

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L

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F

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I

A

A

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K

G

G

G

G

G

G

S

S

A

A

N
|
N

K

K

T

A

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Y

L

L

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L

L

G

G

T

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A

A

A
|
A

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|
C

P

P

P

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Y

Y

H

H

L

I

A

A

I

L

V

V

I

I

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G

G

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M

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|
C

S

S

A
|
A

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D

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G

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F

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G

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P

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T

T
|
T

A

A

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G

R
|
R

M

M

D

D

S

S

Y

Y

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V

D

D

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G

G

G

G

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S

M

Y

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I

M

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L

L

A

A

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|
K

G

G

N

N

R

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S

S

R

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V

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A

C

C

K

K

K

K

H

H

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G

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F

Y

Y

L

L

G

G

S

S

I

I

G

G

G

G

P

P

A

A

A

A

R

I

L

L

A

A

Q

K

D

D

C

S

I

I

R

K

K

Q

V

V

E

T

V

C

F

L

E

A

Y

F

P

P

E

E

L

L

G

G

M

M

E

E

A

A

V

V

W

W

K

K

I

I

E

E

V

V

E

E

D

D

F

F

P

P

A

A

F

F

I

I

V

V

I

V

D

D

D

D

K

K

G

G

N

N

D

D

F

M

F

Y

Q

S

E

K

binding fe3-s4 cluster: C108 (= C99), A226 (= A217), C227 (= C218), C321 (= C312), A323 (= A314), K458 (= K457)
binding fe (iii) ion: N194 (= N185), T435 (= T434), R438 (= R437)

6unzA Crystal structure of cytosolic fumarate hydratase from leishmania major (see paper)
60% identity, 97% coverage: 13:531/535 of query aligns to 25:536/539 of 6unzA

query
sites
6unzA

T

T

P

E

Y

F

R

A

K

K

I

V

S

E

G

G

D

S

H

E

V

K

S

Y

V

V

D

E

T

E

F

V

K

E

-

V

-

F

G

G

Q

R

E

Q

I

A

L

L

T

K

V

V

E

N

P

P

E

E

G

A

I

L

R

T

L

I

L

L

A

A

E

H

T

R

A

A

F

F

A

S

D

D

I

V

N

H

H

H

L

F

L

F

R

R

P

K

G

D

H

H

L

L

K

E

Q

G

L

W

A

R

S

R

I

A

L

I

D

E

D

D

P

P

E

E

A

A

T

S

D

D

N

N

D

D

R

R

F

Y

V

V

A

A

Y

T

D

T

L

L

L

L

K

K

N

N

A

A

N

C

I

I

A

A

A

A

G

G

G

R

V

V

L

L

P

P

M

S

C
|
C

Q
|
Q

D
|
D

T

T

G

G

T

T

A

A

I

I

I

V

M

L

G

G

K

K

K

R

G

G

R

E

R

L

V

C

W

W

T

T

D

G

G

G

E

E

D

D

T

E

A

K

A

Y

L

L

A

S

R

K

G

G

V

I

M

W

D

N

A

A

Y

Y

E

R

K

Y

K

H

N

N

L

L

R

R

Y

Y

S

S

Q

Q

L

T

A

A

P

A

V

L

K

D

M

M

F

F

E

K

E

E

K

C

N

N

T

T

R

G

N

D

N

N

L

L

P

P

A

A

Q

Q

I

L

D

D

I

L

Y

L

E

A

E

V

G

P

T

G

D

S

A

D

Y

Y

E

E

F

F

L

L

F

F

V

I

A

A

K

K

G

G

G

G

G

G

S

S

A

A

N

N

K

K

T

A

F

Y

L

L

Y

Y

Q

Q

G

E

T

T

P

K

S

A

L

L

L

L

T

N

H

P

D

K

R

S

M

L

I

R

D

A

F

F

L

I

K

E

E

E

K

K

I

L

L

K

T

T

L

L

G

G

T

T

A

A

A
|
A

C
|
C

P

P

P

P

Y

Y

H

H

L

I

A

A

I

L

V

V

I

I

G

G

G

G

T

T

S

S

A

A

E

E

M

M

N

T

L

M

K

K

T

T

V

V

K

K

L

L

A

A

S

S

T

C

R

R

Y

Y

L

Y

D

D

E

S

L

L

P

P

T

T

E

T

G

G

S

D

E

K

S

Y

G

G

H

R

A

A

F

F

R

R

D

D

V

P

E

E

M

W

E

E

K

K

E

I

I

V

H

M

K

E

L

V

T

A

Q

Q

Q

K

M

S

G

G

V

I

G

G

A

A

Q

Q

F

F

G

G

G

G

K

K

Y

Y

F

F

C

A

H

H

D

Q

V

A

R

R

V

V

I

I

R

R

L

L

P

P

R

R

H

H

G

G

A

A

S

S

L

C

P

P

I

V

G

G

L

L

G

A

V

V

S

S

C
|
C

S

S

A
|
A

D

D

R

R

Q

Q

A

I

K

L

G

A

R

H

I

I

T

N

R

K

D

S

G

G

I

I

F

Y

V

I

E

E

Q

Q

L

L

E

E

T

Q

D

N

P

P

S

A

K

Q

Y

Y

M

L

P

P

E

-

I

-

D

-

E

-

A

-

K

-

L

-

S

-

E

-

S

T

T

S

V

V

R

K

I

V

D

D

L

L

N

K

R

R

P

P

M

I

A

D

E

K

V

V

L

R

A

Q

E

Q

L

L

S

S

R

Q

H

Y

P

P

V

V

K

G

T

T

R

R

L

V

S

M

L

L

T

N

G

G

T

T

I

L

I

I

V

V

A

A

R

R

D

D

L

I

A

A

H

H

A

A

K

K

I

I

R

K

E

E

R

M

L

M

E

D

K

N

G

G

E

E

G

P

M

L

P

P

D

E

Y

Y

L

M

K

K

N

T

H

S

P

P

V

I

Y

Y

Y

Y

A

A

G

G

P

P

A

A

K

K

T

T

P

P

V

E

G

G

Y

Y

A

A

S

S

G

G

S

S

F

F

G

G

P

P

T

T

T

T

A

A

G

G

R

R

M

M

D

D

S

S

Y

Y

V

V

D

D

Q

L

F

F

Q

Q

S

S

F

H

G

G

G

G

S

S

M

Y

V

I

M

T

L

L

A

A

K
|
K

G

G

N

N

R

R

S

S

R

K

P

Q

V

V

R

T

E

D

A

A

C

C

K

K

K

K

H

H

G

G

G

G

F

F

Y

Y

L

L

G

G

S

S

I

I

G

G

G

G

P

P

A

A

A

A

R

I

L

L

A

A

Q

K

D

D

C

S

I

I

R

K

K

Q

V

V

E

T

V

C

F

L

E

A

Y

F

P

P

E

E

L

L

G

G

M

M

E

E

A

A

V

V

W

W

K

K

I

I

E

E

V

V

E

E

D

D

F

F

P

P

A

A

F

F

I

I

V

V

I

V

D

D

D

D

K

K

G

G

N

N

D

D

F

M

F

Y

Q

S

E

K

binding iron/sulfur cluster: C113 (= C99), Q114 (= Q100), D115 (= D101), A231 (= A217), C232 (= C218), C326 (= C312), A328 (= A314), K462 (= K457)

6msnA Crystal structure of cytosolic fumarate hydratase from leishmania major in a complex with inhibitor thiomalate (see paper)
60% identity, 97% coverage: 13:531/535 of query aligns to 18:529/532 of 6msnA

query
sites
6msnA

T

T

P

E

Y

F

R

A

K

K

I

V

S

E

G

G

D

S

H

E

V

K

S

Y

V

V

D

E

T

E

F

V

K

E

-

V

-

F

G

G

Q

R

E

Q

I

A

L

L

T

K

V

V

E

N

P

P

E

E

G

A

I

L

R

T

L

I

L

L

A

A

E

H

T

R

A

A

F

F

A

S

D

D

I

V

N

H

H

H

L

F

L

F

R

R

P

K

G

D

H

H

L

L

K

E

Q

G

L

W

A

R

S

R

I

A

L

I

D

E

D

D

P

P

E

E

A

A

T

S

D

D

N

N

D

D

R

R

F

Y

V

V

A

A

Y

T

D

T

L

L

L

L

K

K

N

N

A

A

N

C

I

I

A

A

A

A

G

G

G

R

V

V

L

L

P

P

M

S

C
|
C

Q
|
Q

D
|
D

T

T

G

G

T

T

A

A

I

I

I

V

M

L

G

G

K

K

K

R

G

G

R

E

R

L

V

C

W

W

T

T

D

G

G

G

E

E

D

D

T

E

A

K

A

Y

L

L

A

S

R

K

G

G

V

I

M

W

D

N

A

A

Y

Y

E

R

K

Y

K

H

N

N

L

L

R
|
R

Y

Y

S

S

Q

Q

L

T

A

A

P

A

V

L

K

D

M

M

F

F

E

K

E

E

K

C

N

N

T

T

R

G

N

D

N

N

L

L

P

P

A

A

Q

Q

I

L

D

D

I

L

Y

L

E

A

E

V

G

P

T

G

D

S

A

D

Y

Y

E

E

F

F

L

L

F

F

V

I

A

A

K

K

G

G

G

G

G
|
G

S

S

A

A

N

N

K

K

T

A

F

Y

L

L

Y

Y

Q

Q

G

E

T

T

P

K

S

A

L

L

L

L

T

N

H

P

D

K

R

S

M

L

I

R

D

A

F

F

L

I

K

E

E

E

K

K

I

L

L

K

T

T

L

L

G

G

T

T

A

A

A
|
A

C
|
C

P

P

P

P

Y

Y

H

H

L

I

A

A

I

L

V

V

I

I

G

G

G

G

T

T

S

S

A

A

E

E

M

M

N

T

L

M

K

K

T

T

V

V

K

K

L

L

A

A

S

S

T

C

R

R

Y

Y

L

Y

D

D

E

S

L

L

P

P

T

T

E

T

G

G

S

D

E

K

S

Y

G

G

H

R

A

A

F

F

R

R

D

D

V

P

E

E

M

W

E

E

K

K

E

I

I

V

H

M

K

E

L

V

T

A

Q

Q

Q

K

M

S

G

G

V

I

G

G

A

A

Q

Q

F

F

G

G

G

G

K

K

Y

Y

F

F

C

A

H

H

D

Q

V

A

R

R

V

V

I

I

R

R

L

L

P

P

R

R

H

H

G

G

A

A

S

S

L

C

P

P

I

V

G

G

L

L

G

A

V

V

S

S

C
|
C

S

S

A
|
A

D

D

R

R

Q

Q

A

I

K

L

G

A

R

H

I

I

T

N

R

K

D

S

G

G

I

I

F

Y

V

I

E

E

Q

Q

L

L

E

E

T

Q

D

N

P

P

S

A

K

Q

Y

Y

M

L

P

P

E

-

I

-

D

-

E

-

A

-

K

-

L

-

S

-

E

-

S

T

T

S

V

V

R

K

I

V

D

D

L

L

N

K

R

R

P

P

M

I

A

D

E

K

V

V

L

R

A

Q

E

Q

L

L

S

S

R

Q

H

Y

P

P

V

V

K

G

T

T

R

R

L

V

S

M

L

L

T

N

G

G

T

T

I

L

I

I

V

V

A

A

R
|
R

D

D

L

I

A

A

H

H

A

A

K

K

I

I

R

K

E

E

R

M

L

M

E

D

K

N

G

G

E

E

G

P

M

L

P

P

D

E

Y

Y

L

M

K

K

N

T

H

S

P

P

V

I

Y

Y

Y

Y

A

A

G

G

P

P

A

A

K

K

T

T

P

P

V

E

G

G

Y

Y

A

A

S

S

G

G

S

S

F

F

G

G

P

P

T
|
T

T
|
T

A

A

G

G

R
|
R

M

M

D

D

S

S

Y

Y

V

V

D

D

Q

L

F

F

Q

Q

S

S

F

H

G

G

G

G

S

S

M

Y

V

I

M

T

L

L

A

A

K
|
K

G

G

N

N

R

R

S

S

R

K

P

Q

V

V

R

T

E

D

A

A

C

C

K

K

K

K

H

H

G

G

G

G

F

F

Y

Y

L

L

G

G

S

S

I

I

G

G

G

G

P

P

A

A

A

A

R

I

L

L

A

A

Q

K

D

D

C

S

I

I

R

K

K

Q

V

V

E

T

V

C

F

L

E

A

Y

F

P

P

E

E

L

L

G

G

M

M

E

E

A

A

V

V

W

W

K

K

I

I

E

E

V

V

E

E

D

D

F

F

P

P

A

A

F

F

I

I

V

V

I

V

D

D

D

D

K

K

G

G

N

N

D

D

F

M

F

Y

Q

S

E

K

binding (2S)-2-sulfanylbutanedioic acid: Q107 (= Q100), D108 (= D101), R146 (= R139), G189 (= G182), R385 (= R387), T431 (= T433), T432 (= T434), R435 (= R437)
binding iron/sulfur cluster: C106 (= C99), D108 (= D101), A224 (= A217), C225 (= C218), C319 (= C312), A321 (= A314), K455 (= K457)

6uqnB Crystal structure of r173a variant of cytosolic fumarate hydratase from leishmania major in a complex with fumarate and s-malate (see paper)
60% identity, 97% coverage: 13:531/535 of query aligns to 18:529/532 of 6uqnB

query
sites
6uqnB

T

T

P

E

Y

F

R

A

K

K

I

V

S

E

G

G

D

S

H

E

V

K

S

Y

V

V

D

E

T

E

F

V

K

E

-

V

-

F

G

G

Q

R

E

Q

I

A

L

L

T

K

V

V

E

N

P

P

E

E

G

A

I

L

R

T

L

I

L

L

A

A

E

H

T

R

A

A

F

F

A

S

D

D

I

V

N

H

H

H

L

F

L

F

R

R

P

K

G

D

H

H

L

L

K

E

Q

G

L

W

A

R

S

R

I

A

L

I

D

E

D

D

P

P

E

E

A

A

T

S

D

D

N

N

D

D

R

R

F

Y

V

V

A

A

Y

T

D

T

L

L

L

L

K

K

N

N

A

A

N

C

I

I

A

A

A

A

G

G

G

R

V

V

L

L

P

P

M

S

C
|
C

Q
|
Q

D
|
D

T

T

G

G

T

T

A

A

I

I

I

V

M

L

G

G

K

K

K

R

G

G

R

E

R

L

V

C

W

W

T

T

D

G

G

G

E

E

D

D

T

E

A

K

A

Y

L

L

A

S

R

K

G

G

V

I

M

W

D

N

A

A

Y

Y

E

R

K

Y

K

H

N

N

L

L

R

A

Y

Y

S

S

Q

Q

L

T

A

A

P

A

V

L

K

D

M

M

F

F

E

K

E

E

K

C

N

N

T

T

R

G

N

D

N

N

L

L

P

P

A

A

Q

Q

I

L

D

D

I

L

Y

L

E

A

E

V

G

P

T

G

D

S

A

D

Y

Y

E

E

F

F

L

L

F

F

V

I

A

A

K

K

G

G

G

G

G
|
G

S

S

A

A

N

N

K

K

T

A

F

Y

L

L

Y

Y

Q

Q

G

E

T

T

P

K

S

A

L

L

L

L

T

N

H

P

D

K

R

S

M

L

I

R

D

A

F

F

L

I

K

E

E

E

K

K

I

L

L

K

T

T

L

L

G

G

T

T

A

A

A
|
A

C
|
C

P

P

P

P

Y

Y

H

H

L

I

A

A

I

L

V

V

I

I

G

G

G

G

T

T

S

S

A

A

E

E

M

M

N

T

L

M

K

K

T

T

V

V

K

K

L

L

A

A

S

S

T

C

R

R

Y

Y

L

Y

D

D

E

S

L

L

P

P

T

T

E

T

G

G

S

D

E

K

S

Y

G

G

H

R

A

A

F

F

R

R

D

D

V

P

E

E

M

W

E

E

K

K

E

I

I

V

H

M

K

E

L

V

T

A

Q

Q

Q

K

M

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G

G

V

I

G

G

A

A

Q

Q

F

F

G

G

G

G

K

K

Y

Y

F

F

C

A

H

H

D

Q

V

A

R

R

V

V

I

I

R

R

L

L

P

P

R

R

H

H

G

G

A

A

S

S

L

C

P

P

I

V

G

G

L

L

G

A

V

V

S

S

C
|
C

S

S

A
|
A

D

D

R

R

Q

Q

A

I

K

L

G

A

R

H

I

I

T

N

R

K

D

S

G

G

I

I

F

Y

V

I

E

E

Q

Q

L

L

E

E

T

Q

D

N

P

P

S

A

K

Q

Y

Y

M

L

P

P

E

-

I

-

D

-

E

-

A

-

K

-

L

-

S

-

E

-

S

T

T

S

V

V

R

K

I

V

D

D

L

L

N

K

R

R

P

P

M

I

A

D

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V

V

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A

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E

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L

L

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R

Q

H

Y

P

P

V

V

K

G

T

T

R

R

L

V

S

M

L

L

T

N

G

G

T

T

I

L

I

I

V

V

A

A

R
|
R

D

D

L

I

A

A

H

H

A

A

K

K

I

I

R

K

E

E

R

M

L

M

E

D

K

N

G

G

E

E

G

P

M

L

P

P

D

E

Y

Y

L

M

K

K

N

T

H

S

P

P

V

I

Y

Y

Y

Y

A

A

G

G

P

P

A

A

K

K

T

T

P

P

V

E

G

G

Y

Y

A

A

S

S

G

G

S

S

F

F

G

G

P

P

T
|
T

T
|
T

A

A

G

G

R
|
R

M

M

D

D

S

S

Y

Y

V

V

D

D

Q

L

F

F

Q

Q

S

S

F

H

G

G

G

G

S

S

M

Y

V

I

M

T

L

L

A

A

K

K

G

G

N

N

R

R

S

S

R

K

P

Q

V

V

R

T

E

D

A

A

C

C

K

K

K

K

H

H

G

G

G

G

F

F

Y

Y

L

L

G

G

S

S

I

I

G

G

G

G

P

P

A

A

A

A

R

I

L

L

A

A

Q

K

D

D

C

S

I

I

R

K

K

Q

V

V

E

T

V

C

F

L

E

A

Y

F

P

P

E

E

L

L

G

G

M

M

E

E

A

A

V

V

W

W

K

K

I

I

E

E

V

V

E

E

D

D

F

F

P

P

A

A

F

F

I

I

V

V

I

V

D

D

D

D

K

K

G

G

N

N

D

D

F

M

F

Y

Q

S

E

K

binding fumaric acid: Q107 (= Q100), D108 (= D101), G189 (= G182), R385 (= R387), T431 (= T433), T432 (= T434), R435 (= R437)
binding iron/sulfur cluster: C106 (= C99), D108 (= D101), G189 (= G182), A224 (= A217), C225 (= C218), C319 (= C312), A321 (= A314)

Query Sequence

>WP_011652239.1 NCBI__GCF_000009265.1:WP_011652239.1
MADDLFPLGKDATPYRKISGDHVSVDTFKGQEILTVEPEGIRLLAETAFADINHLLRPGH
LKQLASILDDPEATDNDRFVAYDLLKNANIAAGGVLPMCQDTGTAIIMGKKGRRVWTDGE
DTAALARGVMDAYEKKNLRYSQLAPVKMFEEKNTRNNLPAQIDIYEEGTDAYEFLFVAKG
GGSANKTFLYQGTPSLLTHDRMIDFLKEKILTLGTAACPPYHLAIVIGGTSAEMNLKTVK
LASTRYLDELPTEGSESGHAFRDVEMEKEIHKLTQQMGVGAQFGGKYFCHDVRVIRLPRH
GASLPIGLGVSCSADRQAKGRITRDGIFVEQLETDPSKYMPEIDEAKLSESTVRIDLNRP
MAEVLAELSRHPVKTRLSLTGTIIVARDLAHAKIRERLEKGEGMPDYLKNHPVYYAGPAK
TPVGYASGSFGPTTAGRMDSYVDQFQSFGGSMVMLAKGNRSRPVREACKKHGGFYLGSIG
GPAARLAQDCIRKVEVFEYPELGMEAVWKIEVEDFPAFIVIDDKGNDFFQELNLG

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory