Comparing WP_011734567.1 NCBI__GCF_000015045.1:WP_011734567.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 6 hits to proteins with known functional sites (download)
O14289 3-isopropylmalate dehydratase; Alpha-IPM isomerase; IPMI; Isopropylmalate isomerase; EC 4.2.1.33 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
34% identity, 91% coverage: 6:165/175 of query aligns to 545:706/758 of O14289
Sites not aligning to the query:
Q58667 Methanogen homoaconitase small subunit; HACN; Homoaconitate hydratase; EC 4.2.1.114 from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) (see paper)
35% identity, 89% coverage: 15:170/175 of query aligns to 13:155/170 of Q58667
2pkpA Crystal structure of 3-isopropylmalate dehydratase (leud)from methhanocaldococcus jannaschii dsm2661 (mj1271) (see paper)
35% identity, 89% coverage: 15:170/175 of query aligns to 13:155/167 of 2pkpA
P9WK95 3-isopropylmalate dehydratase small subunit; Alpha-IPM isomerase; IPMI; Isopropylmalate isomerase; EC 4.2.1.33 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
38% identity, 69% coverage: 2:122/175 of query aligns to 5:126/198 of P9WK95
Sites not aligning to the query:
P09339 Aconitate hydratase A; ACN; Aconitase; Aconitate/2-methylaconitate hydratase; Iron-responsive protein-like; IRP-like; RNA-binding protein; EC 4.2.1.3; EC 4.2.1.- from Bacillus subtilis (strain 168) (see 2 papers)
33% identity, 45% coverage: 56:133/175 of query aligns to 777:854/909 of P09339
Sites not aligning to the query:
D9X0I3 Aconitate hydratase A; ACN; Aconitase; EC 4.2.1.3 from Streptomyces viridochromogenes (strain DSM 40736 / JCM 4977 / BCRC 1201 / Tue 494) (see paper)
31% identity, 38% coverage: 60:126/175 of query aligns to 805:871/931 of D9X0I3
Sites not aligning to the query:
>WP_011734567.1 NCBI__GCF_000015045.1:WP_011734567.1
MKTFGGPALFLDRSDINTDEIIPAKYLTEITKEALKPYILEDLKLAGFDPKGETLKQARV
IVSRANFGCGSSREHAPWVFEVNGINTVIAQSFARIFRQNMFNCGMLAIELPQADLERLF
SLAGNDDARICIDIEAQSLALDAGGKTEEFVFQLSPFDKALVMAGGWVDYADRNY
Or try a new SitesBLAST search
SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory