SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing WP_011736417.1 NCBI__GCF_000015045.1:WP_011736417.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

3ea4A Arabidopsis thaliana acetohydroxyacid synthase in complex with monosulfuron-ester (see paper)
46% identity, 99% coverage: 4:563/566 of query aligns to 12:575/582 of 3ea4A

query
sites
3ea4A

N

K

G

G

A

A

R

D

I

I

L

L

L

V

E

E

C

A

L

L

M

E

K

R

E

Q

G

G

V

V

D

E

T

T

V

V

F

F

G

A

Y
|
Y

P

P

G
|
G

G
|
G

T
x
A

V
x
S

L

M

N

E

V

I

Y

H

D

Q

E

A

L

L

F

T

G

R

C

S

K

S

E

S

I

I

R

R

H

N

I

V

M

L

P

P

R

R

H

H

E
|
E

Q

Q

A

G

G

G

T

V

H

F

A

A

A

A

D

E

G

G

Y

Y

A

A

R

R

A

S

T

S

G

G

K

K

V

P

G

G

V

I

A

C

I

I

A

A

T
|
T

S

S

G

G

P

P

G

G

A

A

T

T

N

N

T

L

V

V

T

S

G

G

I

L

A

A

T

D

A

A

Y

L

M

L

D

D

S

S

I

V

P

P

M

L

V

V

I

A

I

I

T

T

G

G

Q

Q

V

V

P

P

T

R

A

R

L

M

I

I

G

G

N

T

D

D

A

A

F
|
F

Q
|
Q

E
|
E

V

T

D

P

I

I

V

V

G

E

I

V

T

T

R

R

S

S

C

I

T

T

K

K

H

H

N

N

F

Y

L

L

V

V

K

M

D

D

V

V

N

E

D

D

I

I

A

P

P

R

I

I

I

I

K

E

K

E

A

A

F

F

Y

F

I

L

A

A

R

T

T

S

G

G

R
|
R

P

P

G

G

P

P

V

V

L

L

V

V

D

D

L

V

P

P

K
|
K

D

D

V

I

Q

Q

I

Q

A

Q

K

L

T

A

E

I

F

P

C

N

Y

W

P

E

E

Q

S

A

V

M

E

R

L

L

R

P

S

G

Y

Y

-

M

-

S

-

R

-

M

-

P

K

K

P

P

T

P

T

E

G

D

G

S

H

H

P

L

R

E

Q

Q

V

I

S

V

K

R

A

L

V

I

S

S

M

-

L

-

L

-

A

E

S

S

H

K

R

K

P

P

V

V

M

L

Y

Y

V

V

G
|
G

G
|
G

G
|
G

V

C

I

L

L

-

S

-

N

N

A

S

A

S

P

D

E

E

L

L

T

G

A

R

L

F

S

V

R

E

L

L

L

T

S

G

I

I

P

P

V

V

T

A

T

T

T
|
T

L
|
L

M
|
M

G

G

L

L

G

G

A

S

F

Y

P

P

G

C

D

D

D

D

V

E

N

L

S

S

L

L

G

H

M

M

L
|
L

G
|
G

M
|
M

H
|
H

G

G

A

T

Y

V

C

Y

A

A

N

N

M

Y

A

A

M

V

T

E

H

H

S

S

D

D

L

L

I

L

V

L

A

A

V

F

G
|
G

A

V

R
|
R

F

F

D
|
D

D
|
D

R
|
R

V
|
V

T

T

G

G

K

K

V

L

D

E

T

A

F

F

A

A

P

S

H

R

A

A

K

K

I

I

I

V

H

H

I

I

D
|
D

V
x
I

D

D

P

S

T

A

S

E

I

I

R

G

K

K

N

N

V

K

R

T

V

P

D

H

L

V

P

S

I

V

V

C

G
|
G

D
|
D

V
|
V

R

K

D

L

V

A

L

L

T

Q

K

G

M

M

I

N

K

K

K

V

V

L

E

E

K

N

S

R

E

A

G

E

D

E

Q

-

A

-

A

-

Y

L

R

K

E

L

S

D

L

F

A

G

P

V

W

W

H

R

E

N

Q

E

I

L

A

N

G

V

W

Q

K

K

E

Q

K

K

H

F

P

P

V

L

S

S

F

F

T

K

R

T

S

F

S

G

A

E

V

A

I

I

K

P

P

P

Q

Q

F

Y

V

A

I

I

Q

K

K

V

L

L

R

D

E

E

L

L

S

T

D

D

R

G

D

K

A

A

I

I

V

I

S

S

T

T

D

G

V
|
V

G
|
G

Q
|
Q

H
|
H

Q

Q

M
|
M

W

W

T

A

A

A

Q

Q

F

F

F

Y

S

N

F

Y

T

K

G

K

P

P

R

R

T

Q

L

W

L

L

T

S

S

S

G
|
G

G

G

L

L

G
|
G

T

A

M
|
M

G

G

F

F

G

G

L

L

P

P

A

A

A

A

M

I

G

G

A

A

Q

S

A

V

A

A

F

N

P

P

G

D

R

A

Q

I

V

V

I

V

A

D

I

I

C

D

G
|
G

D
|
D

G
|
G

G
x
S

I

F

Q

I

M

M

N

N

I

V

Q

Q

E

E

M

L

A

A

T

T

L

I

V

R

Q

V

N

E

R

N

L

L

P

P

V

V

K

K

I

V

V

L

I

L

I

L

N

N

N
|
N

N

Q

F
x
H

L
|
L

G
|
G

M
|
M

V
|
V

R

M

Q

Q

W
|
W

Q

E

E

D

M

R

F

F

F

Y

D

K

K

A

R

N

Y

R

S

A

Q

H

S

T

C

F

L

L

-

G

-

D

-

P

-

A

-

Q

-

E

-

D

E

E

L

I

P

F

I

P

D

N

Y

M

I

L

K

L

L

F

A

A

D

A

A

A

Y

C

G

G

A

I

K

P

G

A

F

A

V

R

A

V

S

T

K

K

P

K

S

A

E

D

V

L

E

R

T

E

V

A

I

I

R

Q

Q

T

G

M

F

L

A

D

E

T

P

P

G

G

P

P

V

Y

I

L

M

L

E

D

F

V

R

I

V

C

A

P

R
x
H

E

Q

E

E

K

H

V

V

L

L

P

P

M

M

V

I

P

P

S
|
S

G

G

A

G

S

T

L

F

N

N

E

D

M

V

L

I

active site: Y32 (= Y24), G34 (= G26), G35 (= G27), A36 (≠ T28), S37 (≠ V29), E58 (= E50), T81 (= T73), F120 (= F112), Q121 (= Q113), E122 (= E114), K170 (= K162), M265 (= M257), V292 (= V284), V399 (= V394), G425 (= G420), M427 (= M422), D452 (= D447), N479 (= N474), H481 (≠ F476), L482 (= L477), M484 (= M479), V485 (= V480), W488 (= W483), H557 (≠ R545)
binding methyl 2-{[(4-methylpyrimidin-2-yl)carbamoyl]sulfamoyl}benzoate: D290 (= D282), R291 (= R283), W488 (= W483), S567 (= S555)
binding flavin-adenine dinucleotide-n5-isobutyl ketone: R160 (= R152), G221 (= G211), G222 (= G212), G223 (= G213), T245 (= T237), L246 (= L238), M247 (= M239), L263 (= L255), G264 (= G256), M265 (= M257), H266 (= H258), G285 (= G277), R287 (= R279), D289 (= D281), R291 (= R283), D309 (= D301), I310 (≠ V302), G327 (= G319), D328 (= D320), V329 (= V321), M404 (= M399), G422 (= G417)
binding magnesium ion: D452 (= D447), N479 (= N474), H481 (≠ F476)
binding 2-[(2e)-3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-(1-hydroxyethylidene)-4-methyl-2,3-dihydro-1,3-thiazol-5-yl]ethyltrihydrogen diphosphate: V399 (= V394), G400 (= G395), Q401 (= Q396), H402 (= H397), M427 (= M422), G451 (= G446), D452 (= D447), G453 (= G448), S454 (≠ G449), N479 (= N474), H481 (≠ F476), L482 (= L477), G483 (= G478), M484 (= M479), V485 (= V480)

3e9yA Arabidopsis thaliana acetohydroxyacid synthase in complex with monosulfuron (see paper)
46% identity, 99% coverage: 4:563/566 of query aligns to 12:575/582 of 3e9yA

query
sites
3e9yA

N

K

G

G

A

A

R

D

I

I

L

L

L

V

E

E

C

A

L

L

M

E

K

R

E

Q

G

G

V

V

D

E

T

T

V

V

F

F

G

A

Y
|
Y

P

P

G
|
G

G
|
G

T
x
A

V
x
S

L

M

N

E

V

I

Y

H

D

Q

E

A

L

L

F

T

G

R

C

S

K

S

E

S

I

I

R

R

H

N

I

V

M

L

P

P

R

R

H

H

E
|
E

Q

Q

A

G

G

G

T

V

H

F

A

A

A

A

D

E

G

G

Y

Y

A

A

R

R

A

S

T

S

G

G

K

K

V

P

G

G

V

I

A

C

I

I

A

A

T
|
T

S

S

G

G

P

P

G

G

A

A

T

T

N

N

T

L

V

V

T

S

G

G

I

L

A

A

T

D

A

A

Y

L

M

L

D

D

S

S

I

V

P

P

M

L

V

V

I

A

I

I

T

T

G

G

Q

Q

V

V

P

P

T

R

A

R

L

M

I

I

G

G

N

T

D

D

A

A

F
|
F

Q
|
Q

E
|
E

V

T

D

P

I

I

V

V

G

E

I

V

T

T

R

R

S

S

C

I

T

T

K

K

H

H

N

N

F

Y

L

L

V

V

K

M

D

D

V

V

N

E

D

D

I

I

A

P

P

R

I

I

I

I

K

E

K

E

A

A

F

F

Y

F

I

L

A

A

R

T

T

S

G

G

R
|
R

P

P

G

G

P

P

V

V

L

L

V

V

D

D

L

V

P

P

K
|
K

D

D

V

I

Q

Q

I

Q

A

Q

K

L

T

A

E

I

F

P

C

N

Y

W

P

E

E

Q

S

A

V

M

E

R

L

L

R

P

S

G

Y

Y

-

M

-

S

-

R

-

M

-

P

K

K

P

P

T

P

T

E

G

D

G

S

H

H

P

L

R

E

Q

Q

V

I

S

V

K

R

A

L

V

I

S

S

M

-

L

-

L

-

A

E

S

S

H

K

R

K

P

P

V

V

M

L

Y

Y

V

V

G
|
G

G
|
G

G
|
G

V

C

I

L

L

-

S

-

N

N

A

S

A

S

P

D

E

E

L

L

T

G

A

R

L

F

S

V

R

E

L

L

L

T

S

G

I

I

P

P

V

V

T

A

T

T

T
|
T

L
|
L

M
|
M

G

G

L

L

G

G

A

S

F

Y

P

P

G

C

D

D

D

D

V

E

N

L

S

S

L

L

G

H

M

M

L
|
L

G

G

M
|
M

H

H

G

G

A

T

Y

V

C

Y

A

A

N

N

M

Y

A

A

M

V

T

E

H

H

S

S

D

D

L

L

I

L

V

L

A

A

V

F

G
|
G

A

V

R
|
R

F

F

D
|
D

D
|
D

R
|
R

V
|
V

T

T

G

G

K

K

V

L

D

E

T

A

F

F

A

A

P

S

H

R

A

A

K

K

I

I

I

V

H

H

I

I

D
|
D

V
x
I

D

D

P

S

T

A

S

E

I

I

R

G

K

K

N

N

V

K

R

T

V

P

D

H

L

V

P

S

I

V

V

C

G
|
G

D
|
D

V
|
V

R

K

D

L

V

A

L

L

T

Q

K

G

M

M

I

N

K

K

K

V

V

L

E

E

K

N

S

R

E

A

G

E

D

E

Q

-

A

-

A

-

Y

L

R

K

E

L

S

D

L

F

A

G

P

V

W

W

H

R

E

N

Q

E

I

L

A

N

G

V

W

Q

K

K

E

Q

K

K

H

F

P

P

V

L

S

S

F

F

T

K

R

T

S

F

S

G

A

E

V

A

I

I

K

P

P

P

Q

Q

F

Y

V

A

I

I

Q

K

K

V

L

L

R

D

E

E

L

L

S

T

D

D

R

G

D

K

A

A

I

I

V

I

S

S

T

T

D

G

V
|
V

G
|
G

Q
|
Q

H
|
H

Q

Q

M
|
M

W

W

T

A

A

A

Q

Q

F

F

F

Y

S

N

F

Y

T

K

G

K

P

P

R

R

T

Q

L

W

L

L

T

S

S

S

G
|
G

G

G

L

L

G
|
G

T

A

M
|
M

G

G

F

F

G

G

L

L

P

P

A

A

A

A

M

I

G

G

A

A

Q

S

A

V

A

A

F

N

P

P

G

D

R

A

Q

I

V

V

I

V

A

D

I

I

C

D

G
|
G

D
|
D

G
|
G

G
x
S

I

F

Q

I

M

M

N

N

I

V

Q

Q

E

E

M

L

A

A

T

T

L

I

V

R

Q

V

N

E

R

N

L

L

P

P

V

V

K

K

I

V

V

L

I

L

I

L

N

N

N
|
N

N

Q

F
x
H

L
|
L

G
|
G

M
|
M

V
|
V

R

M

Q

Q

W
|
W

Q

E

E

D

M

R

F

F

F

Y

D

K

K

A

R

N

Y

R

S

A

Q

H

S

T

C

F

L

L

-

G

-

D

-

P

-

A

-

Q

-

E

-

D

E

E

L

I

P

F

I

P

D

N

Y

M

I

L

K

L

L

F

A

A

D

A

A

A

Y

C

G

G

A

I

K

P

G

A

F

A

V

R

A

V

S

T

K

K

P

K

S

A

E

D

V

L

E

R

T

E

V

A

I

I

R

Q

Q

T

G

M

F

L

A

D

E

T

P

P

G

G

P

P

V

Y

I

L

M

L

E

D

F

V

R

I

V

C

A

P

R
x
H

E

Q

E

E

K

H

V

V

L

L

P

P

M

M

V

I

P

P

S
|
S

G

G

A

G

S

T

L

F

N

N

E

D

M

V

L

I

active site: Y32 (= Y24), G34 (= G26), G35 (= G27), A36 (≠ T28), S37 (≠ V29), E58 (= E50), T81 (= T73), F120 (= F112), Q121 (= Q113), E122 (= E114), K170 (= K162), M265 (= M257), V292 (= V284), V399 (= V394), G425 (= G420), M427 (= M422), D452 (= D447), N479 (= N474), H481 (≠ F476), L482 (= L477), M484 (= M479), V485 (= V480), W488 (= W483), H557 (≠ R545)
binding N-[(4-methylpyrimidin-2-yl)carbamoyl]-2-nitrobenzenesulfonamide: D290 (= D282), R291 (= R283), W488 (= W483), S567 (= S555)
binding flavin-adenine dinucleotide-n5-isobutyl ketone: R160 (= R152), G221 (= G211), G222 (= G212), G223 (= G213), T245 (= T237), L246 (= L238), M247 (= M239), L263 (= L255), G285 (= G277), R287 (= R279), D289 (= D281), R291 (= R283), D309 (= D301), I310 (≠ V302), G327 (= G319), D328 (= D320), V329 (= V321), M404 (= M399), G422 (= G417)
binding magnesium ion: D452 (= D447), N479 (= N474), H481 (≠ F476)
binding 2-[(2e)-3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-(1-hydroxyethylidene)-4-methyl-2,3-dihydro-1,3-thiazol-5-yl]ethyltrihydrogen diphosphate: V399 (= V394), G400 (= G395), Q401 (= Q396), H402 (= H397), M427 (= M422), G451 (= G446), G453 (= G448), S454 (≠ G449), N479 (= N474), H481 (≠ F476), L482 (= L477), G483 (= G478), M484 (= M479), V485 (= V480)

8et4A Crystal structure of wild-type arabidopsis thaliana acetohydroxyacid synthase in complex with amidosulfuron (see paper)
46% identity, 99% coverage: 4:563/566 of query aligns to 13:576/582 of 8et4A

query
sites
8et4A

N

K

G

G

A

A

R

D

I

I

L

L

L

V

E

E

C

A

L

L

M

E

K

R

E

Q

G

G

V

V

D

E

T

T

V

V

F

F

G

A

Y

Y

P

P

G

G

G

G

T

A

V

S

L

M

N

E

V

I

Y

H

D

Q

E

A

L

L

F

T

G

R

C

S

K

S

E

S

I

I

R

R

H

N

I

V

M

L

P

P

R

R

H

H

E

E

Q

Q

A

G

G

G

T

V

H

F

A

A

A

A

D

E

G

G

Y

Y

A

A

R

R

A

S

T

S

G

G

K

K

V

P

G

G

V

I

A

C

I

I

A

A

T

T

S

S

G

G

P

P

G

G

A

A

T

T

N

N

T

L

V

V

T

S

G

G

I

L

A

A

T

D

A

A

Y

L

M

L

D

D

S

S

I

V

P

P

M

L

V

V

I

A

I

I

T

T

G

G

Q

Q

V

V

P

P

T

R

A

R

L

M

I

I

G

G

N

T

D

D

A

A

F

F

Q

Q

E

E

V

T

D

P

I

I

V

V

G

E

I

V

T

T

R

R

S

S

C

I

T

T

K

K

H

H

N

N

F

Y

L

L

V

V

K

M

D

D

V

V

N

E

D

D

I

I

A

P

P

R

I

I

I

I

K

E

K

E

A

A

F

F

Y

F

I

L

A

A

R

T

T

S

G

G

R
|
R

P

P

G

G

P

P

V

V

L

L

V

V

D

D

L

V

P

P

K

K

D

D

V

I

Q

Q

I

Q

A

Q

K

L

T

A

E

I

F

P

C

N

Y

W

P

E

E

Q

S

A

V

M

E

R

L

L

R

P

S

G

Y

Y

-

M

-

S

-

R

-

M

-

P

K

K

P

P

T

P

T

E

G

D

G

S

H

H

P

L

R

E

Q

Q

V

I

S

V

K

R

A

L

V

I

S

S

M

-

L

-

L

-

A

E

S

S

H

K

R

K

P

P

V

V

M

L

Y

Y

V

V

G
|
G

G
|
G

G
|
G

V

C

I

L

L

-

S

-

N

N

A

S

A

S

P

D

E

E

L

L

T

G

A

R

L

F

S

V

R

E

L

L

L

T

S

G

I

I

P

P

V

V

T

A

T

S

T
|
T

L
|
L

M
|
M

G

G

L

L

G

G

A

S

F

Y

P

P

G

C

D

D

D

D

V

E

N

L

S

S

L

L

G

H

M

M

L
|
L

G

G

M
|
M

H
|
H

G

G

A

T

Y

V

C

Y

A

A

N

N

M

Y

A

A

M

V

T

E

H

H

S

S

D

D

L

L

I

L

V

L

A

A

V

F

G
|
G

A
x
V

R
|
R

F

F

D
|
D

D

D

R
|
R

V
|
V

T

T

G

G

K

K

V

L

D

E

T

A

F

F

A

A

P

S

H

R

A

A

K

K

I

I

I

V

H

H

I

I

D
|
D

V
x
I

D

D

P

S

T

A

S

E

I

I

R

G

K

K

N

N

V

K

R

T

V

P

D

H

L

V

P

S

I

V

V

C

G

G

D
|
D

V
|
V

R

K

D

L

V

A

L

L

T

Q

K

G

M

M

I

N

K

K

K

V

V

L

E

E

K

N

S

R

E

A

G

E

D

E

Q

-

A

-

A

-

Y

L

R

K

E

L

S

D

L

F

A

G

P

V

W

W

H

R

E

N

Q

E

I

L

A

N

G

V

W

Q

K

K

E

Q

K

K

H

F

P

P

V

L

S

S

F
|
F

T

K

R

T

S

F

S

G

A

E

V

A

I

I

K

P

P

P

Q

Q

F

Y

V

A

I

I

Q

K

K

V

L

L

R

D

E

E

L

L

S

T

D

D

R

G

D

K

A

A

I

I

V

I

S

S

T

T

D

G

V
|
V

G
|
G

Q
|
Q

H
|
H

Q

Q

M
|
M

W

W

T

A

A

A

Q

Q

F

F

F

Y

S

N

F

Y

T

K

G

K

P

P

R

R

T

Q

L

W

L

L

T

S

S

S

G
|
G

G

G

L

L

G
|
G

T

A

M
|
M

G

G

F

F

G

G

L

L

P

P

A

A

A

A

M

I

G

G

A

A

Q

S

A

V

A

A

F

N

P

P

G

D

R

A

Q

I

V

V

I

V

A

D

I

I

C

D

G
|
G

D
|
D

G
|
G

G
x
S

I

F

Q

I

M
|
M

N

N

I

V

Q
|
Q

E

E

M

L

A

A

T

T

L

I

V

R

Q

V

N

E

R

N

L

L

P

P

V

V

K

K

I

V

V

L

I

L

I

L

N

N

N
|
N

N

Q

F
x
H

L
|
L

G
|
G

M
|
M

V
|
V

R

M

Q

Q

W
|
W

Q

E

E

D

M

R

F

F

F

Y

D

K

K

A

R

N

Y

R

S

A

Q

H

S

T

C

F

L

L

-

G

-

D

-

P

-

A

-

Q

-

E

-

D

E

E

L

I

P

F

I

P

D

N

Y

M

I

L

K

L

L

F

A

A

D

A

A

A

Y

C

G

G

A

I

K

P

G

A

F

A

V

R

A

V

S

T

K

K

P
x
K

S

A

E

D

V

L

E

R

T

E

V

A

I

I

R

Q

Q

T

G

M

F

L

A

D

E

T

P

P

G

G

P

P

V

Y

I

L

M

L

E

D

F

V

R

I

V

C

A

P

R

H

E

Q

E

E

K

H

V

V

L

L

P

P

M

M

V

I

P

P

S
|
S

G

G

A

G

S

T

L

F

N

N

E

D

M

V

L

I

binding 2-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-2-[(1~{S})-1-(dioxidanyl)-1-oxidanyl-ethyl]-4-methyl-1,3-thiazol-5-yl]ethyl phosphono hydrogen phosphate: V400 (= V394), G401 (= G395), Q402 (= Q396), H403 (= H397), G426 (= G420), M428 (= M422), G452 (= G446), D453 (= D447), G454 (= G448), S455 (≠ G449), M458 (= M452), N480 (= N474), H482 (≠ F476), L483 (= L477), G484 (= G478), M485 (= M479), V486 (= V480)
binding flavin-adenine dinucleotide: R161 (= R152), G222 (= G211), G223 (= G212), G224 (= G213), T246 (= T237), L247 (= L238), M248 (= M239), L264 (= L255), M266 (= M257), H267 (= H258), G286 (= G277), V287 (≠ A278), R288 (= R279), D290 (= D281), R292 (= R283), V293 (= V284), D310 (= D301), I311 (≠ V302), D329 (= D320), V330 (= V321), M405 (= M399), G423 (= G417)
binding magnesium ion: F370 (= F364), D453 (= D447), M458 (= M452), Q461 (= Q455), N480 (= N474), H482 (≠ F476), K533 (≠ P520)
binding N-{[(4,6-dimethoxypyrimidin-2-yl)carbamoyl]sulfamoyl}-N-methylmethanesulfonamide: M266 (= M257), R292 (= R283), M485 (= M479), W489 (= W483), S568 (= S555)

5wj1A Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a triazolopyrimidine herbicide, penoxsulam (see paper)
46% identity, 99% coverage: 4:563/566 of query aligns to 13:576/582 of 5wj1A

query
sites
5wj1A

N

K

G

G

A

A

R

D

I

I

L

L

L

V

E

E

C

A

L

L

M

E

K

R

E

Q

G

G

V

V

D

E

T

T

V

V

F

F

G

A

Y
|
Y

P

P

G
|
G

G
|
G

T
x
A

V
x
S

L

M

N

E

V

I

Y

H

D

Q

E

A

L

L

F

T

G

R

C

S

K

S

E

S

I

I

R

R

H

N

I

V

M

L

P

P

R

R

H

H

E
|
E

Q

Q

A

G

G

G

T

V

H

F

A

A

A

A

D

E

G

G

Y

Y

A

A

R

R

A

S

T

S

G

G

K

K

V

P

G

G

V

I

A

C

I

I

A

A

T
|
T

S

S

G

G

P

P

G

G

A

A

T

T

N

N

T

L

V

V

T

S

G

G

I

L

A

A

T

D

A

A

Y

L

M

L

D

D

S

S

I

V

P

P

M

L

V

V

I

A

I

I

T

T

G

G

Q

Q

V

V

P

P

T

R

A

R

L

M

I

I

G

G

N

T

D

D

A

A

F
|
F

Q
|
Q

E
|
E

V

T

D

P

I

I

V

V

G

E

I

V

T

T

R

R

S

S

C

I

T

T

K

K

H

H

N

N

F

Y

L

L

V

V

K

M

D

D

V

V

N

E

D

D

I

I

A

P

P

R

I

I

I

I

K

E

K

E

A

A

F

F

Y

F

I

L

A

A

R

T

T

S

G

G

R
|
R

P

P

G

G

P

P

V

V

L

L

V

V

D

D

L

V

P

P

K
|
K

D

D

V

I

Q

Q

I

Q

A

Q

K

L

T

A

E

I

F

P

C

N

Y

W

P

E

E

Q

S

A

V

M

E

R

L

L

R

P

S

G

Y

Y

-

M

-

S

-

R

-

M

-

P

K

K

P

P

T

P

T

E

G

D

G

S

H

H

P

L

R

E

Q

Q

V

I

S

V

K

R

A

L

V

I

S

S

M

-

L

-

L

-

A

E

S

S

H

K

R

K

P

P

V

V

M

L

Y

Y

V

V

G
|
G

G
|
G

G
|
G

V

C

I

L

L

-

S

-

N

N

A

S

A

S

P

D

E

E

L

L

T

G

A

R

L

F

S

V

R

E

L

L

L

T

S

G

I

I

P

P

V

V

T

A

T

S

T
|
T

L
|
L

M
|
M

G

G

L

L

G

G

A

S

F

Y

P

P

G

C

D

D

D

D

V

E

N

L

S

S

L

L

G

H

M
|
M

L
|
L

G

G

M
|
M

H

H

G

G

A

T

Y

V

C

Y

A

A

N

N

M

Y

A

A

M

V

T

E

H

H

S

S

D

D

L

L

I

L

V

L

A

A

V

F

G
|
G

A

V

R
|
R

F

F

D

D

D
|
D

R
|
R

V
|
V

T

T

G

G

K

K

V

L

D

E

T

A

F

F

A

A

P

S

H

R

A

A

K

K

I

I

I

V

H

H

I

I

D
|
D

V
x
I

D

D

P

S

T

A

S

E

I

I

R

G

K

K

N

N

V

K

R

T

V

P

D

H

L

V

P

S

I

V

V

C

G

G

D
|
D

V
|
V

R

K

D

L

V

A

L

L

T

Q

K

G

M

M

I

N

K

K

K

V

V

L

E

E

K

N

S

R

E

A

G

E

D

E

Q

-

A

-

A

-

Y

L

R

K

E

L

S

D

L

F

A

G

P

V

W

W

H

R

E

N

Q

E

I

L

A

N

G

V

W

Q

K

K

E

Q

K

K

H

F

P

P

V

L

S

S

F

F

T

K

R

T

S

F

S

G

A

E

V

A

I

I

K

P

P

P

Q

Q

F

Y

V

A

I

I

Q

K

K

V

L

L

R

D

E

E

L

L

S

T

D

D

R

G

D

K

A

A

I

I

V

I

S

S

T

T

D

G

V
|
V

G
|
G

Q
|
Q

H
|
H

Q

Q

M
|
M

W

W

T

A

A

A

Q

Q

F

F

F

Y

S

N

F

Y

T

K

G

K

P

P

R

R

T

Q

L

W

L

L

T

S

S

S

G
|
G

G
|
G

L

L

G
|
G

T

A

M
|
M

G

G

F

F

G

G

L

L

P

P

A

A

A

A

M

I

G

G

A

A

Q

S

A

V

A

A

F

N

P

P

G

D

R

A

Q

I

V

V

I

V

A

D

I

I

C

D

G

G

D
|
D

G
|
G

G
x
S

I

F

Q

I

M
|
M

N

N

I

V

Q

Q

E

E

M

L

A

A

T

T

L

I

V

R

Q

V

N

E

R

N

L

L

P

P

V

V

K

K

I

V

V

L

I

L

I

L

N

N

N
|
N

N

Q

F
x
H

L
|
L

G
|
G

M
|
M

V
|
V

R

M

Q

Q

W
|
W

Q

E

E

D

M

R

F

F

F

Y

D

K

K

A

R

N

Y

R

S

A

Q

H

S

T

C

F

L

L

-

G

-

D

-

P

-

A

-

Q

-

E

-

D

E

E

L

I

P

F

I

P

D

N

Y

M

I

L

K

L

L

F

A

A

D

A

A

A

Y

C

G

G

A

I

K

P

G

A

F

A

V

R

A

V

S

T

K

K

P

K

S

A

E

D

V

L

E

R

T

E

V

A

I

I

R

Q

Q

T

G

M

F

L

A

D

E

T

P

P

G

G

P

P

V

Y

I

L

M

L

E

D

F

V

R

I

V

C

A

P

R
x
H

E

Q

E

E

K

H

V

V

L

L

P

P

M

M

V

I

P

P

S
|
S

G

G

A

G

S

T

L

F

N

N

E

D

M

V

L

I

active site: Y33 (= Y24), G35 (= G26), G36 (= G27), A37 (≠ T28), S38 (≠ V29), E59 (= E50), T82 (= T73), F121 (= F112), Q122 (= Q113), E123 (= E114), K171 (= K162), M266 (= M257), V293 (= V284), V400 (= V394), G426 (= G420), M428 (= M422), D453 (= D447), N480 (= N474), H482 (≠ F476), L483 (= L477), M485 (= M479), V486 (= V480), W489 (= W483), H558 (≠ R545)
binding flavin-adenine dinucleotide: R161 (= R152), G222 (= G211), G223 (= G212), G224 (= G213), T246 (= T237), L247 (= L238), M248 (= M239), M263 (= M254), L264 (= L255), G286 (= G277), R288 (= R279), V293 (= V284), D310 (= D301), I311 (≠ V302), D329 (= D320), V330 (= V321), M405 (= M399), G423 (= G417), G424 (= G418)
binding magnesium ion: D453 (= D447), N480 (= N474), H482 (≠ F476)
binding 2-(2,2-difluoroethoxy)-N-(5,8-dimethoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-yl)-6-(trifluoromethyl)benzenesulfonamide: M266 (= M257), D291 (= D282), R292 (= R283), M485 (= M479), W489 (= W483), S568 (= S555)
binding (3z)-4-{[(4-amino-2-methylpyrimidin-5-yl)methyl]amino}-3-mercaptopent-3-en-1-yl trihydrogen diphosphate: V400 (= V394), G401 (= G395), Q402 (= Q396), H403 (= H397), M428 (= M422), D453 (= D447), G454 (= G448), S455 (≠ G449), M458 (= M452), N480 (= N474), H482 (≠ F476), L483 (= L477), G484 (= G478), M485 (= M479), V486 (= V480)

5k6tA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylamino-carbonyl-triazolinone herbicide, propoxycarbazone-sodium (see paper)
46% identity, 99% coverage: 4:563/566 of query aligns to 13:576/582 of 5k6tA

query
sites
5k6tA

N

K

G

G

A

A

R

D

I

I

L

L

L

V

E

E

C

A

L

L

M

E

K

R

E

Q

G

G

V

V

D

E

T

T

V

V

F

F

G

A

Y
|
Y

P

P

G
|
G

G
|
G

T
x
A

V
x
S

L

M

N

E

V

I

Y

H

D

Q

E

A

L

L

F

T

G

R

C

S

K

S

E

S

I

I

R

R

H

N

I

V

M

L

P

P

R

R

H

H

E
|
E

Q

Q

A

G

G

G

T

V

H

F

A

A

A

A

D

E

G

G

Y

Y

A

A

R

R

A

S

T

S

G

G

K

K

V

P

G

G

V

I

A

C

I

I

A

A

T
|
T

S

S

G

G

P

P

G

G

A

A

T

T

N

N

T

L

V

V

T

S

G

G

I

L

A

A

T

D

A

A

Y

L

M

L

D

D

S

S

I

V

P

P

M

L

V

V

I

A

I

I

T

T

G

G

Q

Q

V

V

P

P

T

R

A

R

L

M

I

I

G

G

N

T

D

D

A

A

F
|
F

Q
|
Q

E
|
E

V

T

D

P

I

I

V

V

G

E

I

V

T

T

R

R

S

S

C

I

T

T

K

K

H

H

N

N

F

Y

L

L

V

V

K

M

D

D

V

V

N

E

D

D

I

I

A

P

P

R

I

I

I

I

K

E

K

E

A

A

F

F

Y

F

I

L

A

A

R

T

T

S

G

G

R
|
R

P

P

G

G

P

P

V

V

L

L

V

V

D

D

L

V

P

P

K
|
K

D

D

V

I

Q

Q

I

Q

A

Q

K

L

T

A

E

I

F

P

C

N

Y

W

P

E

E

Q

S

A

V

M

E

R

L

L

R

P

S

G

Y

Y

-

M

-

S

-

R

-

M

-

P

K

K

P

P

T

P

T

E

G

D

G

S

H

H

P

L

R

E

Q

Q

V

I

S

V

K

R

A

L

V

I

S

S

M

-

L

-

L

-

A

E

S

S

H

K

R

K

P

P

V

V

M

L

Y

Y

V

V

G
|
G

G
|
G

G
|
G

V

C

I

L

L

-

S

-

N

N

A

S

A

S

P

D

E

E

L

L

T

G

A

R

L

F

S

V

R

E

L

L

L

T

S

G

I

I

P

P

V

V

T

A

T

S

T
|
T

L
|
L

M
|
M

G

G

L

L

G

G

A

S

F

Y

P

P

G

C

D

D

D

D

V

E

N

L

S

S

L

L

G

H

M

M

L
|
L

G

G

M
|
M

H
|
H

G

G

A

T

Y

V

C

Y

A

A

N

N

M

Y

A

A

M

V

T

E

H

H

S

S

D

D

L

L

I

L

V

L

A

A

V

F

G
|
G

A

V

R
|
R

F

F

D
|
D

D

D

R
|
R

V
|
V

T

T

G

G

K

K

V

L

D

E

T

A

F

F

A

A

P

S

H

R

A

A

K

K

I

I

I

V

H

H

I

I

D
|
D

V
x
I

D

D

P

S

T

A

S

E

I

I

R

G

K

K

N

N

V

K

R

T

V

P

D

H

L

V

P

S

I

V

V

C

G

G

D
|
D

V
|
V

R

K

D

L

V

A

L

L

T

Q

K

G

M

M

I

N

K

K

K

V

V

L

E

E

K

N

S

R

E

A

G

E

D

E

Q

-

A

-

A

-

Y

L

R

K

E

L

S

D

L

F

A

G

P

V

W

W

H

R

E

N

Q

E

I

L

A

N

G

V

W

Q

K

K

E

Q

K

K

H

F

P

P

V

L

S

S

F

F

T

K

R

T

S

F

S

G

A

E

V

A

I

I

K

P

P

P

Q

Q

F

Y

V

A

I

I

Q

K

K

V

L

L

R

D

E

E

L

L

S

T

D

D

R

G

D

K

A

A

I

I

V

I

S

S

T

T

D

G

V
|
V

G
|
G

Q
|
Q

H
|
H

Q
|
Q

M
|
M

W

W

T

A

A

A

Q

Q

F

F

F

Y

S

N

F

Y

T

K

G

K

P

P

R

R

T

Q

L

W

L

L

T

S

S

S

G
|
G

G

G

L

L

G
|
G

T

A

M
|
M

G

G

F

F

G

G

L

L

P

P

A

A

A

A

M

I

G

G

A

A

Q

S

A

V

A

A

F

N

P

P

G

D

R

A

Q

I

V

V

I

V

A

D

I

I

C

D

G
|
G

D
|
D

G
|
G

G
x
S

I

F

Q

I

M

M

N

N

I

V

Q

Q

E

E

M

L

A

A

T

T

L

I

V

R

Q

V

N

E

R

N

L

L

P

P

V

V

K

K

I

V

V

L

I

L

I

L

N

N

N
|
N

N

Q

F
x
H

L
|
L

G
|
G

M
|
M

V
|
V

R

M

Q

Q

W
|
W

Q

E

E

D

M

R

F

F

F

Y

D

K

K

A

R

N

Y

R

S

A

Q

H

S

T

C

F

L

L

-

G

-

D

-

P

-

A

-

Q

-

E

-

D

E

E

L

I

P

F

I

P

D

N

Y

M

I

L

K

L

L

F

A

A

D

A

A

A

Y

C

G

G

A

I

K

P

G

A

F

A

V

R

A

V

S

T

K

K

P

K

S

A

E

D

V

L

E

R

T

E

V

A

I

I

R

Q

Q

T

G

M

F

L

A

D

E

T

P

P

G

G

P

P

V

Y

I

L

M

L

E

D

F

V

R

I

V

C

A

P

R
x
H

E

Q

E

E

K

H

V

V

L

L

P

P

M

M

V

I

P

P

S
|
S

G

G

A

G

S

T

L

F

N

N

E

D

M

V

L

I

active site: Y33 (= Y24), G35 (= G26), G36 (= G27), A37 (≠ T28), S38 (≠ V29), E59 (= E50), T82 (= T73), F121 (= F112), Q122 (= Q113), E123 (= E114), K171 (= K162), M266 (= M257), V293 (= V284), V400 (= V394), G426 (= G420), M428 (= M422), D453 (= D447), N480 (= N474), H482 (≠ F476), L483 (= L477), M485 (= M479), V486 (= V480), W489 (= W483), H558 (≠ R545)
binding methyl 2-[(4-methyl-5-oxidanylidene-3-propoxy-1,2,4-triazol-1-yl)carbonylsulfamoyl]benzoate: H267 (= H258), R292 (= R283), M485 (= M479), W489 (= W483), S568 (= S555)
binding flavin-adenine dinucleotide: R161 (= R152), G222 (= G211), G223 (= G212), G224 (= G213), T246 (= T237), L247 (= L238), M248 (= M239), L264 (= L255), G286 (= G277), R288 (= R279), D290 (= D281), R292 (= R283), V293 (= V284), D310 (= D301), I311 (≠ V302), D329 (= D320), V330 (= V321), Q404 (= Q398), M405 (= M399), G423 (= G417)
binding magnesium ion: D453 (= D447), N480 (= N474), H482 (≠ F476)
binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V400 (= V394), G401 (= G395), Q402 (= Q396), H403 (= H397), G426 (= G420), M428 (= M422), G452 (= G446), G454 (= G448), S455 (≠ G449), N480 (= N474), H482 (≠ F476), L483 (= L477), G484 (= G478)

5k6rA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with a sulfonylamino-carbonyl-triazolinone herbicide, thiencarbazone-methyl (see paper)
46% identity, 99% coverage: 4:563/566 of query aligns to 13:576/582 of 5k6rA

query
sites
5k6rA

N

K

G

G

A

A

R

D

I

I

L

L

L

V

E

E

C

A

L

L

M

E

K

R

E

Q

G

G

V

V

D

E

T

T

V

V

F

F

G

A

Y
|
Y

P

P

G
|
G

G
|
G

T
x
A

V
x
S

L

M

N

E

V

I

Y

H

D

Q

E

A

L

L

F

T

G

R

C

S

K

S

E

S

I

I

R

R

H

N

I

V

M

L

P

P

R

R

H

H

E
|
E

Q

Q

A

G

G

G

T

V

H

F

A

A

A

A

D

E

G

G

Y

Y

A

A

R

R

A

S

T

S

G

G

K

K

V

P

G

G

V

I

A

C

I

I

A

A

T
|
T

S

S

G

G

P

P

G

G

A

A

T

T

N

N

T

L

V

V

T

S

G

G

I

L

A

A

T

D

A

A

Y

L

M

L

D

D

S

S

I

V

P

P

M

L

V

V

I

A

I

I

T

T

G

G

Q

Q

V

V

P

P

T

R

A

R

L

M

I

I

G

G

N

T

D

D

A

A

F
|
F

Q
|
Q

E
|
E

V

T

D

P

I

I

V

V

G

E

I

V

T

T

R

R

S

S

C

I

T

T

K

K

H

H

N

N

F

Y

L

L

V

V

K

M

D

D

V

V

N

E

D

D

I

I

A

P

P

R

I

I

I

I

K

E

K

E

A

A

F

F

Y

F

I

L

A

A

R

T

T

S

G

G

R
|
R

P

P

G

G

P

P

V

V

L

L

V

V

D

D

L

V

P

P

K
|
K

D

D

V

I

Q

Q

I

Q

A

Q

K

L

T

A

E

I

F

P

C

N

Y

W

P

E

E

Q

S

A

V

M

E

R

L

L

R

P

S

G

Y

Y

-

M

-

S

-

R

-

M

-

P

K

K

P

P

T

P

T

E

G

D

G

S

H

H

P

L

R

E

Q

Q

V

I

S

V

K

R

A

L

V

I

S

S

M

-

L

-

L

-

A

E

S

S

H

K

R

K

P

P

V

V

M

L

Y

Y

V

V

G
|
G

G
|
G

G
|
G

V

C

I

L

L

-

S

-

N

N

A

S

A

S

P

D

E

E

L

L

T

G

A

R

L

F

S

V

R

E

L

L

L

T

S

G

I

I

P

P

V

V

T

A

T

S

T
|
T

L
|
L

M
|
M

G

G

L

L

G

G

A

S

F

Y

P

P

G

C

D

D

D

D

V

E

N

L

S

S

L

L

G

H

M

M

L
|
L

G

G

M
|
M

H

H

G

G

A

T

Y

V

C

Y

A

A

N

N

M

Y

A

A

M

V

T

E

H

H

S

S

D

D

L

L

I

L

V

L

A

A

V

F

G
|
G

A

V

R
|
R

F

F

D

D

D

D

R
|
R

V
|
V

T

T

G

G

K

K

V

L

D

E

T

A

F

F

A

A

P

S

H

R

A

A

K

K

I

I

I

V

H

H

I

I

D
|
D

V
x
I

D

D

P

S

T

A

S

E

I

I

R

G

K

K

N

N

V

K

R

T

V

P

D

H

L

V

P

S

I

V

V

C

G
|
G

D
|
D

V
|
V

R

K

D

L

V

A

L

L

T

Q

K

G

M

M

I

N

K

K

K

V

V

L

E

E

K

N

S

R

E

A

G

E

D

E

Q

-

A

-

A

-

Y

L

R

K

E

L

S

D

L

F

A

G

P

V

W

W

H

R

E

N

Q

E

I

L

A

N

G

V

W

Q

K

K

E

Q

K

K

H

F

P

P

V

L

S

S

F

F

T

K

R

T

S

F

S

G

A

E

V

A

I

I

K

P

P

P

Q

Q

F

Y

V

A

I

I

Q

K

K

V

L

L

R

D

E

E

L

L

S

T

D

D

R

G

D

K

A

A

I

I

V

I

S

S

T

T

D

G

V
|
V

G
|
G

Q
|
Q

H
|
H

Q

Q

M
|
M

W

W

T

A

A

A

Q

Q

F

F

F

Y

S

N

F

Y

T

K

G

K

P

P

R

R

T

Q

L

W

L

L

T

S

S

S

G
|
G

G

G

L

L

G
|
G

T

A

M
|
M

G

G

F

F

G

G

L

L

P

P

A

A

A

A

M

I

G

G

A

A

Q

S

A

V

A

A

F

N

P

P

G

D

R

A

Q

I

V

V

I

V

A

D

I

I

C

D

G

G

D
|
D

G
|
G

G
x
S

I

F

Q

I

M
|
M

N

N

I

V

Q

Q

E

E

M

L

A

A

T

T

L

I

V

R

Q

V

N

E

R

N

L

L

P

P

V

V

K

K

I

V

V

L

I

L

I

L

N

N

N
|
N

N

Q

F
x
H

L
|
L

G
|
G

M
|
M

V
|
V

R

M

Q

Q

W
|
W

Q

E

E

D

M

R

F

F

F

Y

D

K

K

A

R

N

Y

R

S

A

Q

H

S

T

C

F

L

L

-

G

-

D

-

P

-

A

-

Q

-

E

-

D

E

E

L

I

P

F

I

P

D

N

Y

M

I

L

K

L

L

F

A

A

D

A

A

A

Y

C

G

G

A

I

K

P

G

A

F

A

V

R

A

V

S

T

K

K

P

K

S

A

E

D

V

L

E

R

T

E

V

A

I

I

R

Q

Q

T

G

M

F

L

A

D

E

T

P

P

G

G

P

P

V

Y

I

L

M

L

E

D

F

V

R

I

V

C

A

P

R
x
H

E

Q

E

E

K

H

V

V

L

L

P

P

M

M

V

I

P

P

S
|
S

G

G

A

G

S

T

L

F

N

N

E

D

M

V

L

I

active site: Y33 (= Y24), G35 (= G26), G36 (= G27), A37 (≠ T28), S38 (≠ V29), E59 (= E50), T82 (= T73), F121 (= F112), Q122 (= Q113), E123 (= E114), K171 (= K162), M266 (= M257), V293 (= V284), V400 (= V394), G426 (= G420), M428 (= M422), D453 (= D447), N480 (= N474), H482 (≠ F476), L483 (= L477), M485 (= M479), V486 (= V480), W489 (= W483), H558 (≠ R545)
binding methyl 4-[(3-methoxy-4-methyl-5-oxidanylidene-1,2,4-triazol-1-yl)carbonylsulfamoyl]-5-methyl-thiophene-3-carboxylate: R292 (= R283), W489 (= W483), S568 (= S555)
binding flavin-adenine dinucleotide: R161 (= R152), G222 (= G211), G223 (= G212), G224 (= G213), T246 (= T237), L247 (= L238), M248 (= M239), L264 (= L255), M266 (= M257), G286 (= G277), R288 (= R279), R292 (= R283), V293 (= V284), D310 (= D301), I311 (≠ V302), G328 (= G319), D329 (= D320), V330 (= V321), M405 (= M399), G423 (= G417)
binding magnesium ion: D453 (= D447), N480 (= N474), H482 (≠ F476)
binding 2-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl}ethyl trihydrogendiphosphate: V400 (= V394), G401 (= G395), Q402 (= Q396), H403 (= H397), G426 (= G420), M428 (= M422), D453 (= D447), G454 (= G448), S455 (≠ G449), M458 (= M452), N480 (= N474), H482 (≠ F476), L483 (= L477), G484 (= G478), M485 (= M479), V486 (= V480)

1z8nA Crystal structure of arabidopsis thaliana acetohydroxyacid synthase in complex with an imidazolinone herbicide, imazaquin (see paper)
46% identity, 99% coverage: 4:563/566 of query aligns to 13:576/582 of 1z8nA

query
sites
1z8nA

N

K

G

G

A

A

R

D

I

I

L

L

L

V

E

E

C

A

L

L

M

E

K

R

E

Q

G

G

V

V

D

E

T

T

V

V

F

F

G

A

Y
|
Y

P

P

G
|
G

G
|
G

T
x
A

V
x
S

L

M

N

E

V

I

Y

H

D

Q

E

A

L

L

F

T

G

R

C

S

K

S

E

S

I

I

R

R

H

N

I

V

M

L

P

P

R

R

H

H

E
|
E

Q

Q

A

G

G

G

T

V

H

F

A

A

A

A

D

E

G

G

Y

Y

A

A

R

R

A

S

T

S

G

G

K

K

V

P

G

G

V

I

A

C

I

I

A

A

T
|
T

S

S

G

G

P

P

G

G

A

A

T

T

N

N

T

L

V

V

T

S

G

G

I

L

A

A

T

D

A

A

Y

L

M

L

D

D

S

S

I

V

P

P

M

L

V

V

I

A

I

I

T

T

G

G

Q

Q

V

V

P

P

T

R

A

R

L

M

I

I

G

G

N

T

D

D

A

A

F
|
F

Q
|
Q

E
|
E

V

T

D

P

I

I

V

V

G

E

I

V

T

T

R

R

S

S

C

I

T

T

K
|
K

H

H

N

N

F

Y

L

L

V

V

K

M

D

D

V

V

N

E

D

D

I

I

A

P

P

R

I

I

I

I

K

E

K

E

A

A

F

F

Y

F

I

L

A

A

R

T

T

S

G

G

R
|
R

P

P

G

G

P

P

V

V

L

L

V

V

D

D

L

V

P

P

K
|
K

D

D

V

I

Q

Q

I

Q

A

Q

K

L

T

A

E

I

F

P

C

N

Y

W

P

E

E

Q

S

A

V

M

E

R

L

L

R

P

S

G

Y
|
Y

-

M

-

S

-
x
R

-

M

-

P

K

K

P

P

T

P

T

E

G

D

G

S

H

H

P

L

R

E

Q

Q

V

I

S

V

K

R

A

L

V

I

S

S

M

-

L

-

L

-

A

E

S

S

H

K

R

K

P

P

V

V

M

L

Y

Y

V

V

G
|
G

G

G

G
|
G

V

C

I

L

L

-

S

-

N

N

A

S

A

S

P

D

E

E

L

L

T

G

A

R

L

F

S

V

R

E

L

L

L

T

S

G

I

I

P

P

V

V

T

A

T

S

T
|
T

L
|
L

M
|
M

G

G

L

L

G

G

A

S

F

Y

P

P

G

C

D

D

D

D

V

E

N

L

S

S

L

L

G

H

M

M

L
|
L

G
|
G

M
|
M

H
|
H

G

G

A

T

Y

V

C

Y

A

A

N

N

M

Y

A

A

M

V

T

E

H

H

S

S

D

D

L

L

I

L

V

L

A

A

V

F

G
|
G

A
x
V

R
|
R

F

F

D
|
D

D
|
D

R
|
R

V
|
V

T

T

G

G

K

K

V

L

D

E

T

A

F

F

A

A

P

S

H

R

A

A

K

K

I

I

I

V

H

H

I

I

D
|
D

V
x
I

D
|
D

P

S

T

A

S

E

I

I

R

G

K

K

N

N

V

K

R

T

V

P

D

H

L

V

P

S

I

V

V

C

G

G

D
|
D

V
|
V

R

K

D

L

V

A

L

L

T

Q

K

G

M

M

I

N

K

K

K

V

V

L

E

E

K

N

S

R

E

A

G

E

D

E

Q

-

A

-

A

-

Y

L

R

K

E

L

S

D

L

F

A

G

P

V

W

W

H

R

E

N

Q

E

I

L

A

N

G

V

W

Q

K

K

E

Q

K

K

H

F

P

P

V

L

S

S

F

F

T

K

R

T

S

F

S

G

A

E

V

A

I

I

K

P

P

P

Q

Q

F

Y

V

A

I

I

Q

K

K

V

L

L

R

D

E

E

L

L

S

T

D

D

R

G

D

K

A

A

I

I

V

I

S

S

T

T

D

G

V
|
V

G
|
G

Q
|
Q

H
|
H

Q

Q

M
|
M

W

W

T

A

A

A

Q

Q

F

F

F

Y

S

N

F

Y

T

K

G

K

P

P

R

R

T

Q

L

W

L

L

T

S

S

S

G
|
G

G
|
G

L

L

G
|
G

T

A

M
|
M

G

G

F

F

G

G

L

L

P

P

A

A

A

A

M

I

G

G

A

A

Q

S

A

V

A

A

F

N

P

P

G

D

R

A

Q

I

V

V

I

V

A

D

I

I

C

D

G
|
G