SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing WP_011736873.1 NCBI__GCF_000015045.1:WP_011736873.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

O23346 Imidazoleglycerol-phosphate dehydratase 2, chloroplastic; IGPD 2; Protein HISTIDINE BIOSYNTHESIS 5B; EC 4.2.1.19 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
49% identity, 99% coverage: 3:195/195 of query aligns to 76:269/272 of O23346

query
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O23346

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E86 (= E13) binding substrate
H112 (= H39) binding Mn(2+)
112:120 (vs. 39:47, 56% identical) binding substrate
H138 (= H65) binding Mn(2+)
HHTNE 138:142 (≠ HHTVE 65:69) binding substrate
H139 (= H66) binding Mn(2+)
E142 (= E69) binding Mn(2+)
R164 (= R91) binding substrate
R186 (= R113) binding substrate
H210 (≠ E137) binding Mn(2+)
H234 (= H161) binding Mn(2+)
234:242 (vs. 161:169, 89% identical) binding substrate
H235 (= H162) binding Mn(2+)
E238 (= E165) binding Mn(2+)
SSK 264:266 (≠ STK 190:192) binding substrate

Sites not aligning to the query:

73 E→Q: Loss of activity.

5el9A A. Thaliana igpd2 in complex with the triazole-phosphonate inhibitor, (s)-c348, to 1.1a resolution (see paper)
49% identity, 99% coverage: 3:195/195 of query aligns to 3:196/199 of 5el9A

query
sites
5el9A

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binding [(2S)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]phosphonic acid: R91 (= R91), R113 (= R113), S191 (= S190), K193 (= K192)

P34047 Imidazoleglycerol-phosphate dehydratase 1, chloroplastic; IGPD 1; Protein HISTIDINE BIOSYNTHESIS 5A; EC 4.2.1.19 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
49% identity, 99% coverage: 3:195/195 of query aligns to 74:267/270 of P34047

query
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P34047

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H110 (= H39) binding Mn(2+)
H136 (= H65) binding Mn(2+)
H137 (= H66) binding Mn(2+)
E140 (= E69) binding Mn(2+)
H208 (≠ E137) binding Mn(2+)
H232 (= H161) binding Mn(2+)
H233 (= H162) binding Mn(2+)
E236 (= E165) binding Mn(2+)

5ekwA A. Thaliana igpd2 in complex with the racemate of the triazole- phosphonate inhibitor, c348 (see paper)
48% identity, 98% coverage: 3:193/195 of query aligns to 3:194/194 of 5ekwA

query
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5ekwA

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binding [(2S)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]phosphonic acid: R91 (= R91), R113 (= R113), S191 (= S190), K193 (= K192)
binding [(2R)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]phosphonic acid: R91 (= R91), R113 (= R113), S191 (= S190), K193 (= K192)

4qnkA The structure of wt a. Thaliana igpd2 in complex with mn2+ and phosphate (see paper)
49% identity, 93% coverage: 3:184/195 of query aligns to 3:184/185 of 4qnkA

query
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4qnkA

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binding manganese (ii) ion: H39 (= H39), H65 (= H65), E69 (= E69), H137 (≠ E137), H161 (= H161), E165 (= E165)
binding phosphate ion: Q43 (≠ L43), H47 (= H47), K169 (= K169)

4mu1A The structure of wt a. Thaliana igpd2 in complex with mn2+, imidazole, and sulfate at 1.5 a resolution (see paper)
49% identity, 93% coverage: 3:184/195 of query aligns to 3:184/185 of 4mu1A

query
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4mu1A

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binding imidazole: H65 (= H65), E69 (= E69)
binding manganese (ii) ion: H65 (= H65), E69 (= E69), H137 (≠ E137)

4mu0A The structure of wt a. Thaliana igpd2 in complex with mn2+ and 1,2,4- triazole at 1.3 a resolution (see paper)
49% identity, 93% coverage: 3:184/195 of query aligns to 3:184/185 of 4mu0A

query
sites
4mu0A

R

R

T

I

A

G

T

E

I

V

E

K

R

R

N

E

T

T

S

K

E

E

T

T

R

N

I

V

R

S

L

V

T

K

L

I

N

N

I

L

D

D

G

G

R

H

G

G

E

V

T

S

S

D

I

S

G

S

S

T

G

G

V

I

P

P

F

F

L

L

D

D

H

H

M

M

L

L

N

D

L

Q

F

L

A

A

R

S

H

H

G

G

L

L

F

F

D

D

L

V

S

H

L

V

E

R

A

A

C

T

G

G

D

D

T

T

Q

H

I

I

D

D

F

D

H
|
H

T

T

V

N

E
|
E

D

D

I

V

G

A

I

L

V

A

L

I

G

G

E

T

A

A

F

L

K

L

Q

K

A

A

L

L

A

G

D

E

K

R

Q

K

G

G

I

I

N

N

R

R

Y

F

G

G

Q

D

V

F

T

T

V

A

P

P

M

L

D

D

E

E

T

A

L

L

A

I

S

H

A

V

V

S

V

L

D

D

I

L

S

S

G

G

R

R

P

P

Y

Y

L

L

V

G

Y

Y

N

N

V

L

D

E

L

I

P

P

K

T

A

Q

K

R

V

V

G

G

D

T

F

Y

D

D

V

T

E

Q

L

L

A

V

Q

E

E
x
H

F

F

Q

Q

A

S

F

L

A

V

N

N

H

T

C

S

G

G

I

M

N

T

L

L

H

H

I

I

N

R

L

Q

L

L

Y

A

G

G

D

K

N

N

L

S

H

H

I

I

E

E

A

A

C

T

F

F

K

K

A

A

V

F

G

A

R

R

A

A

M

L

D

R

M

Q

A

A

T

T

R

E

L

S

D

D

P

P

R

R

binding manganese (ii) ion: H65 (= H65), E69 (= E69), H137 (≠ E137)
binding 1,2,4-triazole: H65 (= H65), H66 (= H66)

4mu3A The form a structure of an e21q catalytic mutant of a. Thaliana igpd2 in complex with mn2+ and a mixture of its substrate, 2r3s-igp, and an inhibitor, 2s3s-igp, to 1.12 a resolution (see paper)
48% identity, 93% coverage: 3:184/195 of query aligns to 3:184/186 of 4mu3A

query
sites
4mu3A

R

R

T

I

A

G

T

E

I

V

E

K

R

R

N

E

T

T

S

K

E
x
Q

T

T

R

N

I

V

R

S

L

V

T

K

L

I

N

N

I

L

D

D

G

G

R

H

G

G

E

V

T

S

S

D

I

S

G

S

S

T

G

G

V

I

P

P

F

F

L

L

D

D

H

H

M

M

L

L

N

D

L

Q

F

L

A

A

R

S

H

H

G

G

L

L

F

F

D

D

L

V

S

H

L

V

E

R

A

A

C

T

G

G

D

D

T

T

Q

H

I

I

D

D

F

D

H
|
H

T

T

V

N

E
|
E

D

D

I

V

G

A

I

L

V

A

L

I

G

G

E

T

A

A

F

L

K

L

Q

K

A

A

L

L

A

G

D

E

K

R

Q

K

G

G

I

I

N

N

R

R

Y

F

G

G

Q

D

V

F

T

T

V

A

P

P

M

L

D

D

E

E

T

A

L

L

A

I

S

H

A

V

V

S

V

L

D

D

I

L

S

S

G

G

R

R

P

P

Y

Y

L

L

V

G

Y

Y

N

N

V

L

D

E

L

I

P

P

K

T

A

Q

K

R

V

V

G

G

D

T

F

Y

D

D

V

T

E

Q

L

L

A

V

Q

E

E
x
H

F

F

Q

Q

A

S

F

L

A

V

N

N

H

T

C

S

G

G

I

M

N

T

L

L

H

H

I

I

N

R

L

Q

L

L

Y

A

G

G

D

K

N

N

L

S

H

H

I

I

E

E

A

A

C

T

F

F

K

K

A

A

V

F

G

A

R

R

A

A

M

L

D

R

M

Q

A

A

T

T

R

E

L

S

D

D

P

P

R

R

binding (2S,3S)-2,3-dihydroxy-3-(1H-imidazol-5-yl)propyl dihydrogen phosphate: H65 (= H65), H66 (= H66)
binding (2R,3S)-2,3-dihydroxy-3-(1H-imidazol-5-yl)propyl dihydrogen phosphate: Q13 (≠ E13), H65 (= H65), H66 (= H66)
binding manganese (ii) ion: H65 (= H65), E69 (= E69), H137 (≠ E137)

2f1dA X-ray structure of imidazoleglycerol-phosphate dehydratase (see paper)
49% identity, 93% coverage: 3:184/195 of query aligns to 2:183/183 of 2f1dA

query
sites
2f1dA

R

R

T

I

A

G

T

E

I

V

E

K

R

R

N

V

T

T

S

K

E

E

T

T

R

N

I

V

R

S

L

V

T

K

L

I

N

N

I

L

D

D

G

G

R

T

G

G

E

V

T

A

S

D

I

S

G

S

S

S

G

G

V

I

P

P

F

F

L

L

D

D

H
|
H

M

M

L

L

N

D

L

Q

F

L

A

A

R

S

H

H

G

G

L

L

F

F

D

D

L

V

S

H

L

V

E

R

A

A

C

T

G

G

D

D

T

V

Q

H

I

I

D

D

F

D

H
|
H

H

H

T

T

V

N

E
|
E

D

D

I

I

G

A

I

L

V

A

L

I

G

G

E

T

A

A

F

L

K

L

Q

K

A

A

L

L

A

G

D

E

K

R

Q

K

G

G

I

I

N

N

R

R

Y

F

G

G

Q

D

V

F

T

T

V

A

P

P

M

L

D

D

E

E

T

A

L

L

A

I

S

H

A

V

V

S

V

L

D

D

I

L

S

S

G

G

R

R

P

P

Y

Y

L

L

V

G

Y

Y

N

N

V

L

D

E

L

I

P

P

K

T

A

Q

K

R

V

V

G

G

D

T

F

Y

D

D

V

T

E

Q

L

L

A

V

Q

E

E
x
H

F

F

Q

Q

A

S

F

L

A

V

N

N

H

T

C

S

G

G

I

M

N

T

L

L

H

H

I

I

N

R

L

Q

L

L

Y

A

G

G

D

E

N

N

L

S

H
|
H

H

H

I

I

E
|
E

A

A

C

T

F

F

K

K

A

A

V

F

G

A

R

R

A

A

M

L

D

R

M

Q

A

A

T

T

R

E

L

T

D

D

P

P

R

R

binding manganese (ii) ion: H38 (= H39), H64 (= H65), E68 (= E69), H136 (≠ E137), H160 (= H161), E164 (= E165)

8qawA Medicago truncatula hisn5 (igpd) in complex with mn, imd, edo, fmt, gol and trs (see paper)
48% identity, 93% coverage: 3:184/195 of query aligns to 3:184/185 of 8qawA

query
sites
8qawA

R

R

T

I

A

G

T

E

I

M

E

K

R

R

N

V

T

T

S

K

E
|
E

T

T

R

N

I

V

R

S

L

V

T

K

L

I

N

N

I

L

D

D

G

G

R

T

G

G

E

V

T

A

S

D

I

N

G

S

S

S

G

G

V

I

P

P

F

F

L

L

D

D

H
|
H

M

M

L

L

N

D

L
x
Q

F

L

A

A

R

S

H
|
H

G

G

L

L

F

F

D

D

L

V

S

H

L

V

E

K

A

A

C

T

G

G

D

D

T

T

Q

H

I

I

D

D

F

D

H
|
H

T

T

V

N

E
|
E

D

D

I

V

G

A

I

L

V

A

L

I

G

G

E

T

A

A

F

L

K

L

Q

Q

A

A

L

L

A

G

D

D

K

R

Q

K

G

G

I

I

N

N

R

R

Y

F

G

G

Q

N

V

F

T

S

V

A

P

P

M

L

D

D

E

E

T

A

L

L

A

V

S

H

A

V

V

S

V

L

D

D

I

L

S

S

G

G

R

R

P

P

Y

H

L

L

V

G

Y

Y

N

D

V

L

D

N

L

I

P

P

K

T

A

Q

K

R

V

V

G

G

D

K

F

Y

D

D

V

T

E

Q

L

L

A

V

Q

E

E
x
H

F

F

Q

Q

A

S

F

L

A

V

N

N

H

T

C

S

G

G

I

M

N

T

L

L

H

H

I

I

N

R

L

Q

L

F

Y

S

G

G

D

T

N

N

L

S

H
|
H

H

H

I

I

E
|
E

A

A

C

T

F

F

K
|
K

A

A

V

F

G

A

R

R

A

A

M

L

D

R

M

Q

A

A

T

T

R

E

L

Y

D

D

P

T

R

R

binding glycerol: Q43 (≠ L43), H47 (= H47), K169 (= K169)
binding imidazole: E13 (= E13), H66 (= H66), E69 (= E69)
binding manganese (ii) ion: H39 (= H39), H65 (= H65), E69 (= E69), H137 (≠ E137), H161 (= H161), E165 (= E165)

8qavA Medicago truncatula hisn5 (igpd) in complex with mn and ig2 (see paper)
48% identity, 93% coverage: 3:184/195 of query aligns to 2:183/184 of 8qavA

query
sites
8qavA

R

R

T

I

A

G

T

E

I

M

E

K

R

R

N

V

T

T

S

K

E

E

T

T

R

N

I

V

R

S

L

V

T

K

L

I

N

N

I

L

D

D

G

G

R

T

G

G

E

V

T

A

S

D

I

N

G

S

S

S

G

G

V

I

P

P

F

F

L

L

D

D

H
|
H

M

M

L

L

N

D

L

Q

F

L

A

A

R

S

H

H

G

G

L

L

F

F

D

D

L

V

S

H

L

V

E

K

A

A

C

T

G

G

D

D

T

T

Q

H

I

I

D

D

F

D

H
|
H

T

T

V

N

E
|
E

D

D

I

V

G

A

I

L

V

A

L

I

G

G

E

T

A

A

F

L

K

L

Q

Q

A

A

L

L

A

G

D

D

K

R

Q

K

G

G

I

I

N

N

R

R

Y

F

G

G

Q

N

V

F

T

S

V

A

P

P

M

L

D

D

E

E

T

A

L

L

A

V

S

H

A

V

V

S

V

L

D

D

I

L

S

S

G

G

R

R

P

P

Y

H

L

L

V

G

Y

Y

N

D

V

L

D

N

L

I

P

P

K

T

A

Q

K

R

V

V

G

G

D

K

F

Y

D

D

V

T

E

Q

L

L

A

V

Q

E

E
x
H

F

F

Q

Q

A

S

F

L

A

V

N

N

H

T

C

S

G

G

I

M

N

T

L

L

H

H

I

I

N

R

L

Q

L

F

Y

S

G

G

D

T

N

N

L

S

H
|
H

H

H

I

I

E
|
E

A

A

C

T

F

F

K

K

A

A

V

F

G

A

R

R

A

A

M

L

D

R

M

Q

A

A

T

T

R

E

L

Y

D

D

P

T

R

R

binding (2S,3S)-2,3-dihydroxy-3-(1H-imidazol-5-yl)propyl dihydrogen phosphate: H64 (= H65), H65 (= H66)
binding manganese (ii) ion: H38 (= H39), H64 (= H65), E68 (= E69), H136 (≠ E137), H160 (= H161), E164 (= E165)

6fwhA Acanthamoeba igpd in complex with r-c348 to 1.7a resolution (see paper)
46% identity, 99% coverage: 3:195/195 of query aligns to 3:195/196 of 6fwhA

query
sites
6fwhA

R

R

T

E

A

A

T

Q

I

V

E

A

R

R

N

E

T

T

S

G

E
|
E

T

T

R

K

I

I

R

E

L

V

T

R

L

L

N

S

I

L

D

D

G

G

R

T

G

G

E

V

T

S

S

D

I

V

G

K

S

T

G

G

V

I

P

G

F

F

L

L

D

D

H
|
H

M

M

L

L

N

S

L

A

F

L

A

A

R

K

H

H

G

G

L

R

F

F

D

D

L

L

S

Y

L

L

E

R

A

C

C

A

G

G

D

D

T

L

Q

H

I

V

D

D

F

D

H
|
H

T

T

V

S

E
|
E

D

D

I

C

G

A

I

I

V

V

L

L

G

G

E

Q

A

A

F

F

K

R

Q

Q

A

A

L

I

A

G

D

E

K

R

Q

K

G

G

I

I

N

K

R
|
R

Y

Y

G

G

Q

S

V

A

T

Y

V

A

P

P

M

L

D

D

E

E

T

S

L

L

A

A

S

R

A

A

V

V

D

D

I

I

S

S

G

S

R
|
R

P

P

Y

F

L

A

V

V

Y

I

N

D

V

L

D

K

L

L

P

K

K

R

A

E

K

K

V

I

G

G

D

E

F

L

D

S

V

C

E

E

L

M

A

I

Q

P

E
x
H

F

V

F

L

Q

H

A

S

F

F

A

A

N

T

H

S

C

A

G

N

I

L

N

T

L

L

H

H

I

V

N

E

L

V

L

L

Y

Y

G

G

D

A

N

N

L

D

H
|
H

I

K

I

A

E
|
E

A

S

C

A

F

F

K

K

A

A

V

T

G

A

R

L

A

A

M

L

D

R

M

E

A

A

T

V

R

T

L

K

D

D

P

G

R

P

V

A

E

D

G

A

V

V

M

P

S
|
S

T

T

K
|
K

G

G

V

V

L

L

binding [(2R)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]phosphonic acid: E13 (= E13), H39 (= H39), H65 (= H65), H66 (= H66), E69 (= E69), R91 (= R91), R113 (= R113), H161 (= H161), H162 (= H162), E165 (= E165), S190 (= S190), K192 (= K192)
binding manganese (ii) ion: H39 (= H39), H65 (= H65), E69 (= E69), H137 (≠ E137), H161 (= H161), E165 (= E165)

6fwhL Acanthamoeba igpd in complex with r-c348 to 1.7a resolution (see paper)
46% identity, 99% coverage: 3:195/195 of query aligns to 2:194/195 of 6fwhL

query
sites
6fwhL

R

R

T

E

A

A

T
x
Q

I

V

E

A

R

R

N

E

T

T

S

G

E
|
E

T

T

R

K

I

I

R

E

L

V

T

R

L

L

N

S

I

L

D

D

G

G

R

T

G

G

E

V

T

S

S

D

I

V

G

K

S

T

G

G

V

I

P

G

F

F

L

L

D

D

H
|
H

M

M

L

L

N

S

L

A

F

L

A

A

R

K

H

H

G

G

L

R

F

F

D

D

L

L

S

Y

L

L

E

R

A

C

C

A

G

G

D

D

T

L

Q

H

I

V

D

D

F

D

H
|
H

T

T

V

S

E
|
E

D

D

I

C

G

A

I

I

V

V

L

L

G

G

E

Q

A

A

F

F

K

R

Q
|
Q

A

A

L

I

A

G

D

E

K

R

Q

K

G

G

I

I

N

K

R
|
R

Y

Y

G

G

Q

S

V

A

T

Y

V

A

P

P

M

L

D

D

E

E

T

S

L

L

A

A

S

R

A

A

V

V

D

D

I

I

S

S

G

S

R
|
R

P

P

Y

F

L

A

V

V

Y

I

N

D

V

L

D

K

L

L

P

K

K

R

A

E

K

K

V

I

G

G

D

E

F

L

D

S

V

C

E

E

L

M

A

I

Q

P

E
x
H

F

V

F

L

Q

H

A

S

F

F

A

A

N

T

H

S

C

A

G

N

I

L

N

T

L

L

H

H

I

V

N

E

L

V

L

L

Y

Y

G

G

D

A

N

N

L

D

H
|
H

I

K

I

A

E
|
E

A

S

C

A

F

F

K

K

A

A

V

T

G

A

R

L

A

A

M

L

D

R

M

E

A

A

T

V

R

T

L

K

D

D

P

G

R

P

V

A

E

D

G

A

V

V

M

P

S
|
S

T

T

K
|
K

G

G

V

V

L

L

binding [(2R)-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl]phosphonic acid: E12 (= E13), H38 (= H39), H64 (= H65), H65 (= H66), E68 (= E69), R90 (= R91), R112 (= R113), H160 (= H161), H161 (= H162), E164 (= E165), S189 (= S190), K191 (= K192)
binding magnesium ion: Q5 (≠ T6), Q80 (= Q81)
binding manganese (ii) ion: H38 (= H39), H64 (= H65), E68 (= E69), H136 (≠ E137), H160 (= H161), E164 (= E165)

P9WML9 Imidazoleglycerol-phosphate dehydratase; IGPD; EC 4.2.1.19 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
46% identity, 94% coverage: 13:195/195 of query aligns to 21:210/210 of P9WML9

query
sites
P9WML9

E

E

T

S

R

D

I

I

R

V

L

I

T

E

L

L

N

D

I

L

D

D

G

G

R

T

G

G

E

Q

T

V

S

A

I

V

G

D

S

T

G

G

V

V

P

P

F

F

L

Y

D

D

H
|
H

M
|
M

L
|
L

N
x
T

L
x
A

F
x
L

A
x
G

R
x
S

H
|
H

G

A

L

S

F

F

D

D

L

L

S

T

L

V

E

R

A

A

C

T

G

G

D

D

T

V

Q

E

I

I

D

E

F

A

H
|
H

T
|
T

V
x
I

E
|
E

D

D

I

T

G

A

I

I

V

A

L

L

G

G

E

T

A

A

F

L

K

G

Q

Q

A

A

L

L

A

G

D

D

K

K

Q

R

G

G

I

I

N

R

R

R

Y

F

G

G

Q

D

V

A

T

F

V

I

P

P

M

M

D

D

E

E

T

T

L

L

A

A

S

H

A

A

V

A

V

V

D

D

I

L

S

S

G

G

R

R

P

P

Y

Y

L

C

V

V

Y

H

N

T

V

G

D

E

-

P

-

D

-

H

L

L

P

Q

K

H

A

T

K

T

V

I

G

A

D

G

F

S

D

S

V

V

E

P

-

Y

-

H

-

T

-

V

L

I

A

N

Q

R

E
x
H

F

V

F

F

Q

E

A

S

F

L

A

A

N

A

H

N

C

A

G

R

I

I

N

A

L

L

H

H

I

V

N

R

L

V

L

L

Y

Y

G

G

D

R

N

D

L

P

H
|
H

I
|
I

I
x
T

E
|
E

A
|
A

C
x
Q

F
x
Y

K
|
K

A

A

V

V

G

A

R

R

A

A

M

L

D

R

M

Q

A

A

T

V

R

E

L

P

D

D

P

P

R

R

V

V

E

S

G

G

V

V

M

P

S

S

T

T

K

K

G

G

V

A

L

L

H47 (= H39) binding Mn(2+)
47:55 (vs. 39:47, 44% identical) binding substrate
H73 (= H65) binding Mn(2+)
HHTIE 73:77 (≠ HHTVE 65:69) binding substrate
H74 (= H66) binding Mn(2+)
E77 (= E69) binding Mn(2+)
H152 (≠ E137) binding Mn(2+)
H176 (= H161) binding Mn(2+)
176:184 (vs. 161:169, 67% identical) binding substrate
H177 (= H162) binding Mn(2+)
E180 (= E165) binding Mn(2+)

Q9S5G5 Histidine biosynthesis bifunctional protein HisB; EC 3.1.3.15; EC 4.2.1.19 from Escherichia coli O157:H7 (see paper)
46% identity, 99% coverage: 3:195/195 of query aligns to 167:355/355 of Q9S5G5

query
sites
Q9S5G5

R

R

T

Y

A

A

T

H

I

V

E

V

R

R

N

N

T

T

S

K

E

E

T

T

R

Q

I

I

R

D

L

V

T

Q

L

V

N

W

I

L

D

D

G

R

R

E

G

G

E

G

T

S

S

K

I

I

G

N

S

T

G

G

V

V

P

G

F

F

L

F

D

D

H

H

M

M

L

L

N

D

L

Q

F

I

A

A

R

T

H

H

G

G

L

G

F

F

D

R

L

M

S

E

L

I

E

N

A

V

C

K

G

G

D

D

T

L

Q

Y

I

I

D

D

F

D

H

H

T

T

V

V

E

E

D

D

I

T

G

G

I

L

V

A

L

L

G

G

E

E

A

A

F

L

K

K

Q

I

A

A

L

L

A

G

D

D

K

K

Q

R

G

G

I

I

N

C

R

R

Y

F

G

G

Q

F

V

V

T

-

V

L

P

P

M

M

D

D

E

E

T

C

L

L

A

A

S

R

A

C

V

A

V

L

D

D

I

I

S

S

G

G

R

R

P

P

Y

H

L

L

V

E

Y

Y

N

K

V

A

D

E

L

F

P

T

K

Y

A

Q

K

R

V

V

G

G

D

D

F

L

D

S

V

T

E

E

L

M

A

I

Q

E

E

H

F

F

Q

R

A

S

F

L

A

S

N

Y

H

T

C

M

G

G

I

V

N

T

L

L

H

H

I

L

N

K

L

-

L

T

Y

K

G

G

D

K

N

N

L

D

H

H

I

R

I

V

E

E

A

S

C

L

F

F

K

K

A

A

V

F

G

G

R

R

A

T

M

L

D

R

M

Q

A

A

T

I

R

-

L

-

D

-

P

-

R

R

V

V

E

E

G

G

-

D

-

T

V

L

M

P

S

S

T

S

K

K

G

G

V

V

L

L

Sites not aligning to the query:

1:166 Histidinol-phosphatase
9 binding Mg(2+)
11 binding Mg(2+)
17 E→A: Severe decrease in histidinol-phosphate phosphatase activity in presence of low magnesium concentration. At higher magnesium concentration (5mM), no effect on activity.
93 binding Zn(2+)
95 binding Zn(2+)
101 binding Zn(2+)
103 binding Zn(2+)
130 binding Mg(2+)

5xdsA Crystal structure of mycobacterium tuberculosis hisb bound with an inhibitor (see paper)
45% identity, 89% coverage: 13:185/195 of query aligns to 12:191/191 of 5xdsA

query
sites
5xdsA

E

E

T

S

R

D

I

I

R

V

L

I

T

E

L

L

N

D

I

L

D

D

G

G

R

T

G

G

E

Q

T

V

S

A

I

V

G

D

S

T

G

G

V

V

P

P

F

F

L

Y

D

D

H
|
H

M

M

L

L

N

T

L

A

F

L

A

G

R

S

H

H

G

A

L

S

F

F

D

D

L

L

S

T

L

V

E

R

A

A

C

T

G

G

D

D

T

V

Q

E

I

I

D

E

F

A

H
|
H

T

T

V

I

E
|
E

D

D

I

T

G

A

I

I

V

A

L

L

G

G

E

T

A

A

F

L

K

G

Q

Q

A

A

L

L

A

G

D

D

K

K

Q

R

G

G

I

I

N

R

R

R

Y

F

G

G

Q

D

V

A

T

F

V

I

P

P

M

M

D

D

E

E

T

T

L

L

A

A

S

H

A

A

V

A

V

V

D

D

I

L

S

S

G

G

R

R

P

P

Y

Y

L

C

V

V

Y

H

N

T

V

G

D

E

-

P

-

D

-

H

L

L

P

Q

K

H

A

T

K

T

V

I

G

A

D

G

F

S

D

S

V

V

E

P

-

Y

-

H

-

T

-

V

L

I

A

N

Q

R

E
x
H

F

V

F

F

Q

E

A

S

F

L

A

A

N

A

H

N

C

A

G

R

I

I

N

A

L

L

H

H

I

V

N

R

L

V

L

L

Y

Y

G

G

D

R

N

D

L

P

H
|
H

H

H

I

I

I

T

E
|
E

A

A

C

Q

F

Y

K

K

A

A

V

V

G

A

R

R

A

A

M

L

D

R

M

Q

A

A

T

V

R

E

L

P

D

D

P

P

R

R

V

V

binding (2S)-2-azanyl-3-(4H-1,2,4-triazol-3-yl)propanoic acid: H64 (= H65), H65 (= H66), E68 (= E69)
binding manganese (ii) ion: H38 (= H39), H64 (= H65), E68 (= E69), H143 (≠ E137), H167 (= H161), E171 (= E165)

4lomA Crystal structure of mycobacterium tuberculosis hisb in complex with its substrate
45% identity, 89% coverage: 13:185/195 of query aligns to 12:191/191 of 4lomA

query
sites
4lomA

E

E

T

S

R

D

I

I

R

V

L

I

T

E

L

L

N

D

I

L

D

D

G

G

R

T

G

G

E

Q

T

V

S

A

I

V

G

D

S

T

G

G

V

V

P

P

F

F

L

Y

D

D

H
|
H

M

M

L

L

N

T

L

A

F

L

A

G

R

S

H

H

G

A

L

S

F

F

D

D

L

L

S

T

L

V

E

R

A

A

C

T

G

G

D

D

T

V

Q

E

I

I

D

E

F

A

H
|
H

H

H

T

T

V

I

E
|
E

D

D

I

T

G

A

I

I

V

A

L

L

G

G

E

T

A

A

F

L

K

G

Q

Q

A

A

L

L

A

G

D

D

K

K

Q

R

G

G

I

I

N

R

R

R

Y

F

G

G

Q

D

V

A

T

F

V

I

P

P

M
|
M

D

D

E

E

T

T

L

L

A

A

S

H

A

A

V

A

V

V

D

D

I

L

S

S

G

G

R

R

P

P

Y

Y

L

C

V

V

Y

H

N

T

V

G

D

E

-

P

-

D

-

H

L

L

P

Q

K

H

A

T

K

T

V

I

G

A

D

G

F

S

D

S

V

V

E

P

-

Y

-

H

-

T

-

V

L

I

A

N

Q

R

E
x
H

F

V

F

F

Q

E

A

S

F

L

A

A

N

A

H

N

C

A

G

R

I

I

N

A

L

L

H

H

I

V

N

R

L

V

L

L

Y

Y

G

G

D

R

N

D

L

P

H
|
H

I

I

I

T

E
|
E

A

A

C

Q

F

Y

K
|
K

A

A

V

V

G

A

R

R

A

A

M

L

D

R

M

Q

A

A

T

V

R

E

L

P

D

D

P

P

R

R

V

V

binding (2R,3S)-2,3-dihydroxy-3-(1H-imidazol-5-yl)propyl dihydrogen phosphate: H38 (= H39), M98 (= M99), H167 (= H161), H168 (= H162), E171 (= E165), K175 (= K169)
binding manganese (ii) ion: H38 (= H39), H64 (= H65), E68 (= E69), H143 (≠ E137), H167 (= H161), E171 (= E165)

4gquA Crystal structure of hisb from mycobacterium tuberculosis
45% identity, 89% coverage: 13:185/195 of query aligns to 12:191/191 of 4gquA

query
sites
4gquA

E

E

T

S

R

D

I

I

R

V

L

I

T

E

L

L

N

D

I

L

D

D

G

G

R

T

G

G

E

Q

T

V

S

A

I

V

G

D

S

T

G

G

V

V

P

P

F

F

L

Y

D

D

H
|
H

M

M

L

L

N

T

L

A

F

L

A

G

R

S

H

H

G

A

L

S

F

F

D

D

L

L

S

T

L

V

E

R

A

A

C

T

G

G

D

D

T

V

Q

E

I

I

D

E

F

A

H
|
H

H

H

T

T

V

I

E
|
E

D

D

I

T

G

A

I

I

V

A

L

L

G

G

E

T

A

A

F

L

K

G

Q

Q

A

A

L

L

A

G

D

D

K

K

Q

R

G

G

I

I

N

R

R

R

Y

F

G

G

Q

D

V

A

T

F

V

I

P

P

M

M

D

D

E

E

T

T

L

L

A

A

S

H

A

A

V

A

V

V

D

D

I

L

S

S

G

G

R

R

P

P

Y

Y

L

C

V

V

Y

H

N

T

V

G

D

E

-

P

-

D

-

H

L

L

P

Q

K

H

A

T

K

T

V

I

G

A

D

G

F

S

D

S

V

V

E

P

-

Y

-

H

-

T

-

V

L

I

A

N

Q

R

E
x
H

F

V

F

F

Q

E

A

S

F

L

A

A

N

A

H

N

C

A

G

R

I

I

N

A

L

L

H

H

I

V

N

R

L

V

L

L

Y

Y

G

G

D

R

N

D

L

P

H
|
H

H

H

I

I

I

T

E
|
E

A

A

C

Q

F

Y

K

K

A

A

V

V

G

A

R

R

A

A

M

L

D

R

M

Q

A

A

T

V

R

E

L

P

D

D

P

P

R

R

V

V

binding manganese (ii) ion: H38 (= H39), H64 (= H65), E68 (= E69), H143 (≠ E137), H167 (= H161), E171 (= E165)

7fcyA Crystal structure of m.Tuberculosis imidazole glycerol phosphate dehydratase in complex with an inhibitor
45% identity, 88% coverage: 13:184/195 of query aligns to 12:190/190 of 7fcyA

query
sites
7fcyA

E

E

T

S

R

D

I

I

R

V

L

I

T

E

L

L

N

D

I

L

D

D

G

G

R

T

G

G

E

Q

T

V

S

A

I

V

G

D

S

T

G

G

V

V

P

P

F

F

L

Y

D

D

H
|
H

M

M

L

L

N

T

L

A

F

L

A

G

R

S

H

H

G

A

L

S

F

F

D

D

L

L

S

T

L

V

E

R

A

A

C

T

G

G

D

D

T

V

Q

E

I

I

D

E

F

A

H
|
H

H

H

T

T

V

I

E
|
E

D

D

I

T

G

A

I

I

V

A

L

L

G

G

E

T

A

A

F

L

K

G

Q

Q

A

A

L

L

A

G

D

D

K

K

Q

R

G

G

I

I

N

R

R

R

Y

F

G

G

Q

D

V

A

T

F

V

I

P

P

M
|
M

D

D

E

E

T

T

L

L

A

A

S

H

A

A

V

A

V

V

D

D

I

L

S

S

G

G

R

R

P

P

Y

Y

L

C

V

V

Y

H

N

T

V

G

D

E

-

P

-

D

-

H

L

L

P

Q

K

H

A

T

K

T

V

I

G

A

D

G

F

S

D

S

V

V

E

P

-

Y

-

H

-

T

-

V

L

I

A

N

Q

R

E
x
H

F

V

F

F

Q

E

A

S

F

L

A

A

N

A

H

N

C

A

G

R

I

I

N

A

L

L

H

H

I

V

N

R

L

V

L

L

Y

Y

G

G

D

R

N

D

L

P

H
|
H

I

I

I

T

E
|
E

A

A

C

Q

F

Y

K

K

A

A

V

V

G

A

R

R

A

A

M

L

D

R

M

Q

A

A

T

V

R

E

L

P

D

D

P

P

R

R

binding (1S)-2-methyl-1-(2-methyl-1,2,4-triazol-3-yl)propan-1-amine: H38 (= H39), M98 (= M99), H167 (= H161), H168 (= H162), E171 (= E165)
binding manganese (ii) ion: H38 (= H39), H64 (= H65), E68 (= E69), H143 (≠ E137), H167 (= H161), E171 (= E165)

7dnqA Crystal structure of m.Tuberculosis imidazole glycerol phosphate dehydratase in complex with an inhibitor
45% identity, 88% coverage: 13:184/195 of query aligns to 12:190/190 of 7dnqA

query
sites
7dnqA

E

E

T

S

R

D

I

I

R

V

L

I

T

E

L

L

N

D

I

L

D

D

G

G

R

T

G

G

E

Q

T

V

S

A

I

V

G

D

S

T

G

G

V

V

P

P

F

F

L

Y

D

D

H
|
H

M

M

L

L

N

T

L

A

F

L

A

G

R

S

H

H

G

A

L

S

F

F

D

D

L

L

S

T

L

V

E

R

A

A

C

T

G

G

D

D

T

V

Q

E

I

I

D

E

F

A

H
|
H

T

T

V

I

E
|
E

D

D

I

T

G

A

I

I

V

A

L

L

G

G

E

T

A

A

F

L

K

G

Q

Q

A

A

L

L

A

G

D

D

K

K

Q

R

G

G

I

I

N

R

R

R

Y

F

G

G

Q

D

V

A

T

F

V

I

P

P

M

M

D

D

E

E

T

T

L

L

A

A

S

H

A

A

V

A

V

V

D

D

I

L

S

S

G

G

R

R

P

P

Y

Y

L

C

V

V

Y

H

N

T

V

G

D

E

-

P

-

D

-

H

L

L

P

Q

K

H

A

T

K

T

V

I

G

A

D

G

F

S

D

S

V

V

E

P

-

Y

-

H

-

T

-

V

L

I

A

N

Q

R

E
x
H

F

V

F

F

Q

E

A

S

F

L

A

A

N

A

H

N

C

A

G

R

I

I

N

A

L

L

H

H

I

V

N

R

L

V

L

L

Y

Y

G

G

D

R

N

D

L

P

H
|
H

H

H

I

I

I

T

E
|
E

A

A

C

Q

F

Y

K

K

A

A

V

V

G

A

R

R

A

A

M

L

D

R

M

Q

A

A

T

V

R

E

L

P

D

D

P

P

R

R

binding 2-(1H-1,2,4-triazol-5-ylsulfanyl)ethanamine: H64 (= H65), H65 (= H66), E68 (= E69)
binding manganese (ii) ion: H38 (= H39), H64 (= H65), E68 (= E69), H143 (≠ E137), H167 (= H161), E171 (= E165)

Query Sequence

>WP_011736873.1 NCBI__GCF_000015045.1:WP_011736873.1
MTRTATIERNTSETRIRLTLNIDGRGETSIGSGVPFLDHMLNLFARHGLFDLSLEACGDT
QIDFHHTVEDIGIVLGEAFKQALADKQGINRYGQVTVPMDETLASAVVDISGRPYLVYNV
DLPKAKVGDFDVELAQEFFQAFANHCGINLHINLLYGDNLHHIIEACFKAVGRAMDMATR
LDPRVEGVMSTKGVL

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory