SitesBLAST
Comparing WP_011765465.1 NCBI__GCF_000061505.1:WP_011765465.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
3ijrF 2.05 angstrom resolution crystal structure of a short chain dehydrogenase from bacillus anthracis str. 'Ames ancestor' in complex with NAD+
58% identity, 97% coverage: 10:288/288 of query aligns to 12:290/290 of 3ijrF
- active site: G57 (= G55), S182 (= S180), L192 (= L190), Y195 (= Y193), K199 (= K197), K240 (≠ E238)
- binding magnesium ion: D55 (= D53), S56 (= S54), E80 (= E78)
- binding nicotinamide-adenine-dinucleotide: P21 (= P19), D55 (= D53), S56 (= S54), G57 (= G55), I58 (= I56), Y77 (= Y75), L78 (= L76), E80 (= E78), G103 (= G101), D104 (= D102), L105 (≠ I103), N131 (= N129), V132 (≠ A130), A133 (= A131), Q134 (≠ E132), I155 (≠ T153), T180 (= T178), S182 (= S180), Y195 (= Y193), K199 (= K197), P225 (= P223), G226 (= G224), P227 (= P225), I228 (= I226), T230 (= T228), L232 (= L230)
3i3oA 2.06 angstrom resolution crystal structure of a short chain dehydrogenase from bacillus anthracis str. 'Ames ancestor' in complex with NAD-acetone
58% identity, 97% coverage: 10:288/288 of query aligns to 4:282/282 of 3i3oA
- active site: G49 (= G55), S174 (= S180), L184 (= L190), Y187 (= Y193), K191 (= K197), K232 (≠ E238)
- binding magnesium ion: D47 (= D53), S48 (= S54), E72 (= E78)
- binding nicotinamide adenine dinucleotide acetone adduct: G45 (= G51), D47 (= D53), S48 (= S54), G49 (= G55), I50 (= I56), Y69 (= Y75), L70 (= L76), E72 (= E78), G95 (= G101), D96 (= D102), L97 (≠ I103), N123 (= N129), V124 (≠ A130), A125 (= A131), Q126 (≠ E132), Q127 (= Q133), I147 (≠ T153), T172 (= T178), S174 (= S180), Y187 (= Y193), K191 (= K197), P217 (= P223), G218 (= G224), I220 (= I226), T222 (= T228), L224 (= L230)
5jydB Crystal structure of a putative short chain dehydrogenase from burkholderia cenocepacia
48% identity, 94% coverage: 12:283/288 of query aligns to 15:288/292 of 5jydB
- active site: G58 (= G55), S184 (= S180), L194 (= L190), Y197 (= Y193), K201 (= K197), P242 (≠ A237)
- binding magnesium ion: D56 (= D53), S57 (= S54), E82 (= E78)
- binding nicotinamide-adenine-dinucleotide: G54 (= G51), D56 (= D53), S57 (= S54), G58 (= G55), I59 (= I56), L79 (= L76), E82 (= E78), D106 (= D102), I107 (= I103), N133 (= N129), A134 (= A130), A135 (= A131), T182 (= T178), S184 (= S180), Y197 (= Y193), K201 (= K197), P227 (= P223), G228 (= G224), P229 (= P225), Y230 (≠ I226), T232 (= T228), L234 (= L230), Q235 (≠ I231)
3r3sA Structure of the ygha oxidoreductase from salmonella enterica
46% identity, 95% coverage: 12:284/288 of query aligns to 15:289/292 of 3r3sA
- active site: G58 (= G55), S184 (= S180), L194 (= L190), Y197 (= Y193), K201 (= K197), Q242 (≠ A237)
- binding magnesium ion: D56 (= D53), S57 (= S54), E82 (= E78)
- binding nicotinamide-adenine-dinucleotide: D56 (= D53), S57 (= S54), G58 (= G55), I59 (= I56), L79 (= L76), E82 (= E78), D106 (= D102), L107 (≠ I103), V133 (≠ N129), A134 (= A130), G135 (≠ A131), S184 (= S180), Y197 (= Y193), K201 (= K197), P227 (= P223), G228 (= G224), I230 (= I226), T232 (= T228), L234 (= L230), Q235 (vs. gap)
P0AG84 Uncharacterized oxidoreductase YghA; EC 1.-.-.- from Escherichia coli (strain K12) (see paper)
46% identity, 95% coverage: 12:284/288 of query aligns to 17:291/294 of P0AG84
- K39 (≠ H34) modified: N6-acetyllysine
8bcjB Crystal structure of short-chain dehydrogenase pa3128 from pseudomonas aeruginosa pao1 in complex with NADP+
39% identity, 83% coverage: 45:283/288 of query aligns to 5:249/250 of 8bcjB
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G11 (= G51), S13 (≠ D53), R14 (≠ S54), G15 (= G55), I16 (= I56), L36 (= L76), R37 (≠ E77), N38 (≠ E78), A61 (≠ G101), D62 (= D102), V63 (≠ I103), N89 (= N129), A90 (= A130), G91 (≠ A131), T113 (= T153), V143 (≠ T178), S145 (= S180), Y159 (= Y193), K163 (= K197), P189 (= P223), G190 (= G224), I192 (= I226), T194 (= T228), I196 (≠ L230), H197 (≠ I231)
7v0hG Crystal structure of putative glucose 1-dehydrogenase from burkholderia cenocepacia in complex with NADP and a potential reaction product
38% identity, 87% coverage: 34:283/288 of query aligns to 1:251/253 of 7v0hG
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G18 (= G51), S20 (≠ D53), K21 (≠ S54), G22 (= G55), I23 (= I56), A43 (≠ L76), S44 (≠ E77), S45 (≠ E78), G68 (= G101), D69 (= D102), V70 (≠ I103), N96 (= N129), S97 (≠ A130), G98 (≠ A131), Y100 (vs. gap), I144 (≠ T178), S146 (= S180), Y159 (= Y193), K163 (= K197), P189 (= P223), G190 (= G224), M191 (≠ P225), I192 (= I226), T194 (= T228), G196 (vs. gap), T197 (vs. gap)
- binding (2R)-2-(hydroxymethyl)pentanedioic acid: S146 (= S180), Y159 (= Y193), M191 (≠ P225), I202 (≠ L230)
3ay6B Crystal structure of bacillus megaterium glucose dehydrogenase 4 a258f mutant in complex with nadh and d-glucose (see paper)
36% identity, 84% coverage: 42:283/288 of query aligns to 11:255/267 of 3ay6B
- active site: G24 (= G55), S151 (= S180), Y164 (= Y193), K168 (= K197)
- binding beta-D-glucopyranose: E102 (≠ Q133), S151 (= S180), H153 (≠ T182), W158 (≠ S187), Y164 (= Y193), N202 (≠ I231), K205 (≠ T234)
- binding 1,4-dihydronicotinamide adenine dinucleotide: G20 (= G51), T23 (≠ S54), G24 (= G55), L25 (≠ I56), Y45 (≠ L76), D71 (= D102), V72 (≠ I103), N98 (= N129), A99 (= A130), G100 (≠ A131), V101 (≠ E132), M149 (≠ T178), S151 (= S180), Y164 (= Y193), K168 (= K197), P194 (= P223), G195 (= G224), M197 (≠ I226), T199 (= T228), P200 (= P229), I201 (≠ L230), N202 (≠ I231)
3osuA Crystal structure of the 3-oxoacyl-acyl carrier protein reductase, fabg, from staphylococcus aureus
36% identity, 83% coverage: 45:283/288 of query aligns to 5:243/246 of 3osuA
4nbuB Crystal structure of fabg from bacillus sp (see paper)
36% identity, 84% coverage: 41:283/288 of query aligns to 4:241/244 of 4nbuB
- active site: G18 (= G55), N111 (= N154), S139 (= S180), Q149 (≠ L190), Y152 (= Y193), K156 (= K197)
- binding acetoacetyl-coenzyme a: D93 (≠ P135), K98 (≠ D141), S139 (= S180), N146 (≠ S187), V147 (≠ A188), Q149 (≠ L190), Y152 (= Y193), F184 (≠ P225), M189 (≠ L230), K200 (= K242)
- binding 1,4-dihydronicotinamide adenine dinucleotide: G14 (= G51), N17 (≠ S54), G18 (= G55), I19 (= I56), D38 (≠ Y75), F39 (≠ L76), V59 (≠ C96), D60 (= D102), V61 (≠ I103), N87 (= N129), A88 (= A130), G89 (≠ A131), I90 (≠ E132), T137 (= T178), S139 (= S180), Y152 (= Y193), K156 (= K197), P182 (= P223), F184 (≠ P225), T185 (≠ I226), T187 (= T228), M189 (≠ L230)
4nbtA Crystal structure of fabg from acholeplasma laidlawii (see paper)
36% identity, 84% coverage: 41:283/288 of query aligns to 2:236/239 of 4nbtA
- active site: G16 (= G55), S132 (= S180), Y145 (= Y193), K149 (= K197)
- binding nicotinamide-adenine-dinucleotide: G12 (= G51), K15 (≠ S54), G16 (= G55), L17 (≠ I56), D36 (≠ Y75), L37 (= L76), L52 (≠ G101), N53 (≠ D102), V54 (≠ I103), N80 (= N129), A81 (= A130), G82 (≠ A131), I130 (≠ T178), S132 (= S180), Y145 (= Y193), K149 (= K197), P177 (= P223), G178 (= G224), I180 (= I226), T182 (= T228)
3sj7A Structure of beta-ketoacetyl-coa reductase (fabg) from staphylococcus aureus complex with NADPH (see paper)
35% identity, 83% coverage: 45:283/288 of query aligns to 2:236/239 of 3sj7A
- active site: G12 (= G55), S138 (= S180), Q148 (≠ L190), Y151 (= Y193), K155 (= K197)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: G8 (= G51), S10 (≠ D53), R11 (≠ S54), I13 (= I56), N31 (≠ A74), Y32 (= Y75), A33 (≠ L76), G34 (≠ E77), S35 (≠ E78), A58 (≠ G101), N59 (≠ D102), V60 (≠ I103), N86 (= N129), A87 (= A130), T109 (= T153), S138 (= S180), Y151 (= Y193), K155 (= K197), P181 (= P223), G182 (= G224)
P40288 Glucose 1-dehydrogenase; EC 1.1.1.47 from Priestia megaterium (Bacillus megaterium) (see 2 papers)
35% identity, 84% coverage: 42:283/288 of query aligns to 5:249/261 of P40288
- 11:35 (vs. 48:72, 48% identical) binding NADP(+)
- E96 (≠ Q133) mutation E->A,G,K: Heat stable.
- D108 (≠ Q146) mutation to N: Heat stable.
- V112 (≠ T150) mutation to A: Heat stable.
- E133 (≠ Q171) mutation to K: Heat stable.
- V183 (= V218) mutation to I: Heat stable.
- P194 (= P229) mutation to Q: Heat stable.
- E210 (≠ G244) mutation to K: Heat stable.
- Y217 (≠ R251) mutation to H: Heat stable.
Sites not aligning to the query:
- 252 Q→L: Heat stable.
- 253 Y→C: Heat stable.
- 258 A→G: Heat stable.
1g6kA Crystal structure of glucose dehydrogenase mutant e96a complexed with NAD+
35% identity, 84% coverage: 42:283/288 of query aligns to 5:249/261 of 1g6kA
- active site: G18 (= G55), S145 (= S180), Y158 (= Y193), K162 (= K197)
- binding nicotinamide-adenine-dinucleotide: T17 (≠ S54), G18 (= G55), L19 (≠ I56), R39 (≠ L76), D65 (= D102), V66 (≠ I103), N92 (= N129), A93 (= A130), G94 (≠ A131), M143 (≠ T178), S145 (= S180), Y158 (= Y193), P188 (= P223), G189 (= G224), I191 (= I226), T193 (= T228)
4wecA Crystal structure of a short chain dehydrogenase from mycobacterium smegmatis
37% identity, 85% coverage: 39:283/288 of query aligns to 5:249/258 of 4wecA
- active site: G21 (= G55), S143 (= S180), Q154 (≠ L190), Y157 (= Y193), K161 (= K197)
- binding nicotinamide-adenine-dinucleotide: G17 (= G51), A19 (≠ D53), S20 (= S54), G21 (= G55), I22 (= I56), D41 (≠ Y75), I42 (≠ L76), V61 (≠ G101), D62 (= D102), V63 (≠ I103), N89 (= N129), T141 (= T178), Y157 (= Y193), K161 (= K197), P187 (= P223), P189 (= P225), V190 (≠ I226)
1vl8B Crystal structure of gluconate 5-dehydrogenase (tm0441) from thermotoga maritima at 2.07 a resolution
35% identity, 85% coverage: 42:287/288 of query aligns to 4:252/252 of 1vl8B
- active site: G17 (= G55), S143 (= S180), I154 (≠ L190), Y157 (= Y193), K161 (= K197)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G13 (= G51), R16 (≠ S54), G17 (= G55), L18 (≠ I56), S37 (≠ Y75), R38 (≠ L76), C63 (≠ G101), D64 (= D102), V65 (≠ I103), A91 (≠ N129), A92 (= A130), G93 (≠ A131), I94 (vs. gap), V114 (≠ T153), I141 (≠ T178), S143 (= S180), Y157 (= Y193), K161 (= K197), P187 (= P223), G188 (= G224), Y190 (≠ I226), T192 (= T228), M194 (≠ L230), T195 (≠ I231)
4iqgD Crystal structure of bpro0239 oxidoreductase from polaromonas sp. Js666 in NADP bound form
35% identity, 83% coverage: 45:283/288 of query aligns to 3:247/248 of 4iqgD
- active site: G13 (= G55), N112 (= N154), S143 (= S180), Y154 (≠ L190), Y157 (= Y193), K161 (= K197)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G9 (= G51), S11 (≠ D53), R12 (≠ S54), G13 (= G55), I14 (= I56), N32 (≠ A74), A34 (≠ L76), S35 (≠ E77), N36 (≠ E78), A59 (≠ G101), D60 (= D102), V61 (≠ I103), N87 (= N129), A88 (= A130), G89 (≠ A131), V141 (≠ T178), S143 (= S180), Y157 (= Y193), K161 (= K197), P187 (= P223), G188 (= G224), I190 (= I226), T192 (= T228), I194 (≠ L230), H195 (≠ I231)
6b9uA Crystal structure of 3-ketoacyl-(acyl-carrier-protein) reductase from brucella melitensis complexed with nadh
38% identity, 84% coverage: 42:283/288 of query aligns to 2:241/244 of 6b9uA
- active site: G15 (= G55), S142 (= S180), L152 (= L190), Y155 (= Y193), K159 (= K197)
- binding 1,4-dihydronicotinamide adenine dinucleotide: G11 (= G51), S14 (= S54), G15 (= G55), F16 (≠ I56), D35 (≠ Y75), R36 (≠ E77), A57 (≠ G101), D58 (= D102), I59 (= I103), N85 (= N129), A86 (= A130), V140 (≠ T178), S142 (= S180), Y155 (= Y193), K159 (= K197), A187 (≠ P225), G188 (≠ I226), T190 (= T228), P191 (= P229), L192 (= L230), F196 (≠ T234)
1ahiA 7 alpha-hydroxysteroid dehydrogenase complexed with nadh and 7-oxo glycochenodeoxycholic acid (see paper)
34% identity, 85% coverage: 41:285/288 of query aligns to 8:251/255 of 1ahiA
- active site: G22 (= G55), S146 (= S180), M156 (≠ L190), Y159 (= Y193), K163 (= K197)
- binding glycochenodeoxycholic acid: S146 (= S180), A148 (≠ T182), N151 (≠ R185), Y159 (= Y193), A196 (≠ L230), V200 (≠ T234)
- binding 1,4-dihydronicotinamide adenine dinucleotide: G18 (= G51), A21 (≠ S54), G22 (= G55), I23 (= I56), D42 (≠ Y75), I43 (≠ L76), D68 (= D102), I69 (= I103), N95 (= N129), Y159 (= Y193), K163 (= K197), P189 (= P223), G190 (= G224), I192 (= I226), T194 (= T228), A196 (≠ L230)
Sites not aligning to the query:
8hsaA Brucella melitensis 7-alpha-hydroxysteroid dehydrogenase mutant: 1-53 truncation/m196i/i258m/k262t-NAD+
35% identity, 83% coverage: 46:285/288 of query aligns to 9:247/248 of 8hsaA
- binding nicotinamide-adenine-dinucleotide: G14 (= G51), I19 (= I56), D38 (≠ Y75), L39 (= L76), C63 (≠ G101), N64 (≠ D102), V65 (≠ I103), N91 (= N129), A92 (= A130), G93 (≠ A131), I140 (≠ T178), S141 (≠ T179), Y155 (= Y193), K159 (= K197), P185 (= P223), G186 (= G224)
Query Sequence
>WP_011765465.1 NCBI__GCF_000061505.1:WP_011765465.1
MSDKDSGHRLPPQHQDEQPGRENEMRPQPEDRMHGYRGSDKLAGKVAIITGGDSGIGRAV
AIAFAKEGADVAVAYLEEHEDAEQTRREVELQGRRCLLMAGDIGNESFTAKLVEQTLSAF
GRLDIVVNNAAEQHPQENFEDISREQLERTFRTNLFSMFDLCRHALPHLQQGACIINTTS
VTAYRGSAHLIDYSATKGAIVSFTRSLAQALAAKRIRVNAVAPGPIWTPLIPATFKAEEV
EKFGAKEPLGRPGQPDEVAPSFVFLASQDASYVTGQVLHPNGGEIVNG
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory