SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing WP_011765962.1 NCBI__GCF_000061505.1:WP_011765962.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

P74285 UTP--glucose-1-phosphate uridylyltransferase; Cyanobacterial UDP-glucose pyrophosphorylase; UDP-glucose pyrophosphorylase; UDP-Glc PPase; EC 2.7.7.9 from Synechocystis sp. (strain PCC 6803 / Kazusa) (see paper)
52% identity, 99% coverage: 3:366/367 of query aligns to 2:365/388 of P74285

query
sites
P74285

K

K

G

A

M

M

I

I

L

L

A

A

A
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A

G

G

Q

K

G

G

T

T

R

R

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P

P

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C

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A8 (= A9) mutation to G: Two-fold decrease in affinity for UTP. No effect on affinity for Glc-1P and on catalytic activity rate.

7d73E Cryo-em structure of gmppa/gmppb complex bound to gtp (state i) (see paper)
29% identity, 90% coverage: 3:333/367 of query aligns to 2:320/360 of 7d73E

query
sites
7d73E

K

K

G

A

M

L

I

I

L
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L

A
x
V

A
x
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G
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G

Q

Y

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T
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T

R
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R

V

L

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R

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P

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L

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G

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E

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W

W

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D

I

I

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G

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E

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R

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L

-

C

-

S

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G

-

P

-

G

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I

-

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-

G

-

N

-

V

E

L

V

V

R

D

P

P

G

S

V

A

W

R

V

I

G

G

L

Q

N

N

T

C

S

S

I

I

A

-

W

-

E

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S

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Q

-

I

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G

G

P

P

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N

V

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H

S

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L

G

G

S

P

G

G

V

V

R

V

I

V

E

E

P

D

G

G

A

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C

V

-

I

I

G

R

P

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G

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W

Y

R

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G

G

E

Q

G

W

Q

V

R

R

F

M

binding guanosine-5'-triphosphate: L6 (= L7), V7 (≠ A8), G8 (≠ A9), G9 (= G10), G11 (= G12), T12 (= T13), R13 (= R14), A52 (≠ N53), S54 (≠ A55), E80 (= E80), P83 (= P92), G85 (= G94), N108 (≠ C117)

7d72K Cryo-em structures of human gmppa/gmppb complex bound to gdp-mannose (see paper)
29% identity, 90% coverage: 3:333/367 of query aligns to 2:320/360 of 7d72K

query
sites
7d72K

K

K

G

A

M

L

I

I

L
|
L

A
x
V

A
x
G

G

G

Q

Y

G

G

T

T

R

R

V

L

R

R

P

P

L

L

T

T

K

L

Y

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L

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I

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E

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E

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H

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G

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E

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P

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L

L

G
|
G

S
x
T

A

A

G

G

G

P

M

L

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A

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L

I

A

Q

R

D

D

F

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G

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E

F

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T

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F

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x
N

G
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S

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D

A

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L

F

D

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A

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G

A

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A

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Y

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G

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G

A

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G

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G

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I

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G

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N

-

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E

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P

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A

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G

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N

N

T

C

S

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A

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W

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E

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S

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Q

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I

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G

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P

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N

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G

G

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G

G

A

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I

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G

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M

binding guanosine-5'-diphosphate-alpha-d-mannose: L6 (= L7), V7 (≠ A8), G8 (≠ A9), G85 (= G94), T86 (≠ S95), N108 (≠ C117), S109 (≠ G118), D110 (= D119), N172 (≠ S184), E194 (≠ G207), D218 (= D232)

7d72E Cryo-em structures of human gmppa/gmppb complex bound to gdp-mannose (see paper)
29% identity, 90% coverage: 3:333/367 of query aligns to 2:320/360 of 7d72E

query
sites
7d72E

K

K

G

A

M

L

I

I

L
|
L

A
x
V

A
x
G

G

G

Q

Y

G

G

T

T

R

R

V

L

R

R

P

P

L

L

T

T

K

L

Y

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L

T

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P

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K

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L

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N

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K

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L

E

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Y

H

L

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I

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E

E

H

A

L

L

A

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A

Y

A

G

G

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D

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A
x
S

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D

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H

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L

L

G
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G

S

T

A

A

G

G

G

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M

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R

A

K

L

I

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R

D

D

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G
x
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D

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D

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x
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E

S

P

P

E

A

V

V

I

L

D

Q

L

R

V

I

P

Q

P

L

G

-

E

Q

A

P

F

T

D

S

I

I

G
x
E

S

K

Q

E

L

V

F

F

P

P

M

I

L

M

V

A

E

K

K

E

S

G

L

Q

P

L

F

Y

F

A

A

M

Q

E

K

L

R

Q

F

G

F

F

N

-

W

W

I

M

D
|
D

I

I

G

G

R

Q

L

P

S

K

D

D

Y

F

W

L

S

T

V

G

L

M

Q

C

R

L

V

F

L

L

R

Q

G

S

E

-

V

-

A

L

Q

R

M

Q

D

K

M

Q

P

P

G

E

R

R

-

L

-

C

-

S

-

G

-

P

-

G

-

I

-

V

-

G

-

N

-

V

E

L

V

V

R

D

P

P

G

S

V

A

W

R

V

I

G

G

L

Q

N

N

T

C

S

S

I

I

A

-

W

-

E

-

S

-

V

-

Q

-

I

-

V

-

G

G

P

P

-

N

V

V

H

S

I

L

G

G

S

P

G

G

V

V

R

V

I

V

E

E

P

D

G

G

A

V

S

C

V

-

I

I

G

R

P

R

S

C

W

T

I

V

G

L

H

R

G

D

S

A

H

R

L

I

R

R

P

S

G

H

A

S

R

W

V

L

E

E

R

S

S

C

I

I

L

V

F

G

P

W

Y

R

T

C

R

R

I

V

G

G

E

Q

G

W

Q

V

R

R

F

M

binding guanosine-5'-diphosphate-alpha-d-mannose: L6 (= L7), V7 (≠ A8), G8 (≠ A9), S54 (≠ A55), G85 (= G94), S109 (≠ G118), N172 (≠ S184), E194 (≠ G207), D218 (= D232)
binding magnesium ion: D110 (= D119), D218 (= D232)

7whsA Cryo-em structure of leishmanial gdp-mannose pyrophosphorylase in complex with gtp (see paper)
28% identity, 92% coverage: 3:338/367 of query aligns to 2:314/366 of 7whsA

query
sites
7whsA

K

R

G

A

M

V

I

I

L
|
L

A
x
V

A
x
G

G
|
G

Q

F

G
|
G

T

T

R
|
R

V

L

R

R

P

P

L

L

T

T

K

L

Y

T

L

T

P

P

K

K

P

P

M

L

V

V

P

P

I

F

L

C

G

N

K

K

P

P

V

M

L

I

E

I

Y

H

L

Q

I

I

E

E

H

A

L

L

A

K

R

A

Y

V

G

G

V

V

D

T

E

E

I

V

M

I

I

L

N
x
A

V

V

A

A

Y

Y

N

R

H

P

Y

E

K

A

I

M

E

K

D

E

Y

Q

F

M

G

D

D

E

G

-

H

-

R

-

W

W

G

S

V

R

Q

K

I

L

G

G

Y

V

S

S

Y

F

E

V

G

F

V

S

R

V

E

E

H

E

G

-

E

-

V

-

P

-

R

E

P

P

L

L

G
|
G

S

T

A

A

G

G

G

P

M

L

R

A

K

L

I

A

Q

R

D

D

F

I

S

L

G

M

F

Q

F

D

D

D

Q

K

T

P

T

F

L

F

V

V

V

L

C
x
N

G

S

D
|
D

A

V

I

T

V

C

D

T

L

F

D

P

I

M

R

Q

A

E

A

L

L

L

D

D

E

F

H

H

R

K

L

A

K

H

G

G

A

G

L

E

A

G

S

T

V

I

I

M

T

V

L

S

E

Q

V

V

P

-

R

-

E

T

Q

Q

V

W

Q

E

N

K

Y

Y

G

G

V

V

-

Y

A

S

D

P

G

Q

D

N

G

Y

R

Q

V

I

L

E

S

R

F

F

Q

V

E

E

K

K

P

P

S

S

P

-

E

-

A

R

A

F

L

L

S

G

T

D

H

R

A

I

S

N

T

A

G

G

I

I

Y

Y

V

I

L

F

E

N

P

K

E

S

V

I

I

L

D

D

L

R

V

I

P

P

G

R

E

R

A

A

F

-

D

S

I

I

G

E

S

K

Q

E

L

I

F

F

P

P

-

A

M

M

L

A

V

A

E

E

K

G

S

Q

L

L

P

Y

F

A

F

F

A

N

Q

L

K

E

R

G

F

F

F

-

N

-

W

W

I

M

D
|
D

I

V

G

G

R

Q

L

P

S

K

D

D

Y

Y

W

I

S

L

V

G

L

M

Q

T

R

K

V

F

L

I

R

-

G

-

E

-

V

-

A

-

Q

-

M

-

D

-

M

-

P

-

G

-

R

-

E

-

V

-

R

-

P

P

G

S

V

L

W

V

V

H

G

G

L

N

N

R

T

E

S

T

I

E

A

A

W

V

E

E

S

H

-

Q

-

R

-

G

-

R

V

F

Q

T

I

V

V

I

G

G

P

A

V

S

H

L

I

I

G

D

S

P

G

S

V

A

R

K

I

I

E

G

P

D

G

G

A

A

S

-

V

V

I

I

G

G

P

P

-

Y

S

A

W

S

I

I

G

G

H

A

G

N

S

C

H

V

L

I

R

G

P

E

G

S

A

C

R

R

V

I

E

D

R

N

S

A

I

A

L

I

F

L

P

E

Y

N

T

S

R

K

I

V

G

G

E

K

G

G

Q

T

R

M

F

V

I

S

D

R

K

S

I

I

V

V

binding guanosine-5'-triphosphate: L6 (= L7), V7 (≠ A8), G8 (≠ A9), G9 (= G10), G11 (= G12), R13 (= R14), A52 (≠ N53), G85 (= G94), N108 (≠ C117), D110 (= D119)
binding magnesium ion: D110 (= D119), D218 (= D232)

4y7vA Structural analysis of muru (see paper)
36% identity, 64% coverage: 3:236/367 of query aligns to 2:204/216 of 4y7vA

query
sites
4y7vA

K

K

G

A

M

M

I

I

L

L

A

A

G
|
G

Q
x
K

G
|
G

T
x
E

R
|
R

V

M

R

R

P

P

L

L

T

T

K

L

Y

H

L

T

P

P

K
|
K

P

P

M

L

V

V

P

P

I

V

L

A

G

G

K

Q

P

P

V

L

L

I

E

E

Y

Y

L

H

I

L

E

R

H

A

L

L

A

A

R

A

Y

A

G

G

V

V

D

T

E

E

I

V

M

V

I

I

N

N

V

H

A

A

Y

W

N

L

H

G

Y

Q

K

Q

I

I

E

E

D

D

Y

H

F

L

G

G

D

D

G

G

H

S

R

R

W

F

G

G

V

L

Q

S

I

I

G

R

Y

Y

S

S

Y

P

E

E

G

G

V

-

R

-

E

-

H

-

G

-

E

-

V

-

P

-

R

E

P

P

L

L

G

E

S

T

A

G

G

G

M

I

R

F

K

K

I

A

Q

L

D

P

F

L

S

L

G

G

F

-

D

D

Q

A

T

P

T

F

L

L

V

L

V

V

C
x
N

G

G

D

D

A

V

I

W

V

T

D

D

L

Y

D

D

I

F

R

-

A

-

A

A

L

R

D

L

E

Q

H

A

R

P

L

L

K

Q

G

G

A

-

L

L

A

A

S

H

V

L

I

V

T

L

L

V

E

D

V

N

P

P

-

G

R

R

E

G

Q
x
D

V

F

Q

R

N

L

Y

V

G

G

V

E

V

Q

V

V

A

V

D

D

G

G

D

D

G

D

R

G

V

T

L

L

S

T

F
|
F

Q

-

E

-

K

-

P

-

S

-

P

-

E

-

A

-

L

-

S

-

T

-

H

-

A

-

S

-

T

S

G

G

I

I

Y

S

V

V

L

L

E

H

P

P

E

A

V

L

I

F

D

E

L

G

V

C

P

Q

P

A

G

G

E

-

A

A

F

F

D

-

I

-

G

-

S

-

Q

K

L

L

F

A

P

P

M

L

L

L

V

R

E

Q

K

A

S

M

L

A

P

A

F

G

F

K

A

V

Q

S

K

G

R

E

F

H

F

Y

-

R

-

G

N

H

W
|
W

I

V

D
|
D

I

V

G

G

R

T

L

L

binding imidodiphosphoric acid: G9 (= G10), K10 (≠ Q11), G11 (= G12), E12 (≠ T13), R13 (= R14), K23 (= K24)
binding 2-acetamido-3-O-[(1R)-1-carboxyethyl]-2-deoxy-1-O-phosphono-alpha-D-glucopyranose: N105 (≠ C117), D137 (≠ Q151), F155 (= F169), W198 (= W230), D200 (= D232)

7whtA Cryo-em structure of leishmanial gdp-mannose pyrophosphorylase in complex with gdp-mannose (see paper)
28% identity, 92% coverage: 3:338/367 of query aligns to 2:308/360 of 7whtA

query
sites
7whtA

K

R

G

A

M

V

I

I

L
|
L

A
x
V

A

G

G
|
G

Q

F

G
|
G

T

T

R

R

V

L

R

R

P

P

L

L

T

T

K

L

Y

T

L

T

P

P

K
|
K

P

P

M

L

V

V

P

P

I

F

L

C

G

N

K

K

P

P

V

M

L

I

E

I

Y

H

L

Q

I

I

E

E

H

A

L

L

A

K

R

A

Y

V

G

G

V

V

D

T

E

E

I

V

M

I

I

L

N

A

V

V

A

A

Y

Y

N

R

H

P

Y

E

K

A

I

M

E

K

D

E

Y

Q

F

M

G

D

D

E

G

-

H

-

R

-

W

W

G

S

V

R

Q

K

I

L

G

G

Y

V

S

S

Y

F

E

V

G

F

V

S

R

V

E

E

H

E

G

-

E

-

V

-

P

-

R

E

P
|
P

L
|
L

G

G

S

T

A

A

G

G

G

P

M

L

R

A

K

L

I

A

Q

R

D

D

F

I

S

L

G

M

F

Q

F

D

D

D

Q

K

T

P

T

F

L

F

V

V

V

L

C
x
N

G
x
S

D
|
D

A

V

I

T

V

C

D

T

L

F

D

P

I

M

R

Q

A

E

A

L

L

L

D

D

E

F

H

H

R

K

L

A

K

H

G

G

A

G

L

E

A

G

S

T

V

I

I

M

T

V

L

V

E

-

V

-

P

-

R

-

E

T

Q

Q

V

W

Q

E

N

K

Y

Y

G

G

V

V

-

Y

A

S

D

P

G

Q

D

N

G

Y

R

Q

V

I

L

E

S

R

F

F

Q

V

E
|
E

K

K

P

P

S

S

P

-

E

-

A

R

A

F

L

L

S

G

T

D

H

R

A

I

S
x
N

T

A

G

G

I

I

Y

Y

V

I

L

F

E

N

P

K

E

S

V

I

I

L

D

D

L

R

V

I

P

P

G

R

E

R

A

A

F

-

D

S

I

I

G
x
E

S

K

Q

E

L

I

F

F

P

P

-

A

M

M

L

A

V

A

E

E

K

G

S

Q

L

L

P

E

F

G

F

F

A

-

Q

-

K

-

R

-

F

-

N

-

W
|
W

I

M

D
|
D

I

V

G

G

R

Q

L

P

S

K

D

D

Y

Y

W

I

S

L

V

G

L

M

Q

T

R

K

V

F

L

I

R

P

G

S

E

L

V

V

A

H

Q

G

M

N

D

R

M

E

P

H

G

T

R

E

E

A

V

V

-

E

-

H

-

Q

R

R

P

G

G

G

V

R

W

F

V

T

G

V

L

I

N

G

T

A

S

S

I

L

A

I

W

D

E

P

S

S

V

A

Q

K

I

-

V

-

G

-

P

-

V

-

H

-

I

I

G

G

S

D

G

G

V

A

R

V

I

I

E

G

P

P

G

Y

A

A

S

S

V

I

I

G

G

A

P

N

S

C

W

V

I

I

G

G

H

E

G

-

S

-

H

-

L

-

R

-

P

-

G

S

A

C

R

R

V

I

E

D

R

N

S

A

I

A

L

I

F

L

P

E

Y

N

T

S

R

K

I

V

G

G

E

K

G

G

Q

T

R

M

F

V

I

S

D

R

K

S

I

I

V

V

binding guanosine-5'-diphosphate-alpha-d-mannose: L6 (= L7), V7 (≠ A8), G9 (= G10), G11 (= G12), K23 (= K24), P83 (= P92), L84 (= L93), N108 (≠ C117), S109 (≠ G118), D110 (= D119), E159 (= E171), N170 (≠ S184), E192 (≠ G207), W209 (= W230), D211 (= D232)
binding magnesium ion: D110 (= D119), D211 (= D232)

4y7uA Structural analysis of muru (see paper)
35% identity, 64% coverage: 3:236/367 of query aligns to 2:209/224 of 4y7uA

query
sites
4y7uA

K

K

G

A

M

M

I

I

L
|
L

A
|
A

G
|
G

Q

K

G
|
G

T
x
E

R
|
R

V

M

R

R

P

P

L

L

T

T

K

L

Y

H

L

T

P

P

K
|
K

P

P

M

L

V

V

P

P

I

V

L

A

G

G

K

Q

P

P

V

L

L

I

E

E

Y

Y

L

H

I

L

E

R

H

A

L

L

A

A

R

A

Y

A

G

G

V

V

D

T

E

E

I

V

M

V

I

I

N

N

V

H

A

A

Y

W

N

L

H

G

Y

Q

K

Q

I

I

E

E

D

D

Y

H

F

L

G

G

D

D

G

G

H

S

R

R

W

F

G

G

V

L

Q

S

I

I

G

R

Y

Y

S

S

Y

P

E

E

G

G

V

-

R

-

E

-

H

-

G

-

E

-

V

-

P

-

R

E

P

P

L

L

G
x
E

S

T

A

G

G

G

M

I

R

F

K

K

I

A

Q

L

D

P

F

L

S

L

G

G

F

-

D

D

Q

A

T

P

T

F

L

L

V

L

V

V

C
x
N

G

G

D
|
D

A

V

I

W

V

T

D

D

L

Y

D

D

I

F

R

-

A

-

A

A

L

R

D

L

E

Q

H

A

R

P

L

L

K

Q

G

G

A

-

L

L

A

A

S

H

V

L

I

V

T

L

L

V

E

D

V

N

P

P

-

G

-

H

-

G

R

R

E

G

Q
x
D

V

F

Q

R

N

L

Y

V

G

G

V

E

V

Q

V

V

A

V

D

D

G

G

D

D

G

D

R

-

V

-

L

-

S

-

F

-

Q

-

E

-

K

-

P

-

S

-

P

-

E

-

A

-

A

A

L

P

S

G

T

T

H

L

A

T

S
x
F

T

S

G

G

I

I

Y

S

V

V

L

L

E

H

P

P

E

A

V

L

I

F

D

E

L

G

V

C

P

Q

P

A

G

G

E

-

A

A

F

F

D

-

I

-

G

-

S

-

Q

K

L

L

F

A

P

P

M

L

L

L

V

R

E

Q

K

A

S

M

L

A

P

A

F

G

F

K

A

V

Q

S

K

G

R

E

F

H

F

Y

-

R

-

G

N

H

W
|
W

I

V

D
|
D

I

V

G

G

R

T

L

L

binding 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]uridine: L6 (= L7), A7 (= A8), A8 (= A9), G9 (= G10), G11 (= G12), E12 (≠ T13), R13 (= R14), K23 (= K24), E84 (≠ G94), D107 (= D119)
binding 2-acetamido-3-O-[(1R)-1-carboxyethyl]-2-deoxy-1-O-phosphono-alpha-D-glucopyranose: N105 (≠ C117), D140 (≠ Q151), F160 (≠ S184), W203 (= W230), D205 (= D232)
binding magnesium ion: D107 (= D119), D205 (= D232)

Q88QT2 N-acetylmuramate alpha-1-phosphate uridylyltransferase; MurNAc-1P uridylyltransferase; MurNAc-alpha-1P uridylyltransferase; EC 2.7.7.99 from Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440) (see paper)
35% identity, 64% coverage: 3:236/367 of query aligns to 2:209/223 of Q88QT2

query
sites
Q88QT2

K

K

G

A

M

M

I

I

L

L

A

A

G

G

Q

K

G
|
G

T
x
E

R
|
R

V

M

R

R

P

P

L

L

T

T

K

L

Y

H

L

T

P

P

K
|
K

P

P

M

L

V

V

P

P

I

V

L

A

G

G

K

Q

P

P

V

L

L

I

E

E

Y

Y

L

H

I

L

E

R

H

A

L

L

A

A

R

A

Y

A

G

G

V

V

D

T

E

E

I

V

M

V

I

I

N

N

V

H

A

A

Y

W

N

L

H

G

Y

Q

K

Q

I

I

E

E

D

D

Y

H

F

L

G

G

D

D

G

G

H

S

R

R

W

F

G

G

V

L

Q

S

I

I

G

R

Y

Y

S

S

Y

P

E

E

G

G

V

-

R

-

E

-

H

-

G

-

E

-

V

-

P

-

R

E

P

P

L

L

G

E

S

T

A

G

G

G

M

I

R

F

K

K

I

A

Q

L

D

P

F

L

S

L

G

G

F

-

D

D

Q

A

T

P

T

F

L

L

V

L

V

V

C
x
N

G

G

D
|
D

A

V

I

W

V

T

D

D

L

Y

D

D

I

F

R

-

A

-

A

A

L

R

D

L

E

Q

H

A

R

P

L

L

K

Q

G

G

A

-

L

L

A

A

S

H

V

L

I

V

T

L

L

V

E

D

V

N

P

P

-

G

-

H

-

G

R

R

E

G

Q
x
D

V

F

Q

R

N

L

Y

V

G

G

V

E

V

Q

V

V

A

V

D

D

G

G

D

D

G

D

R

-

V

-

L

-

S

-

F

-

Q

-

E

-

K

-

P

-

S

-

P

-

E

-

A

-

A

A

L

P

S

G

T

T

H

L

A

T

S

F

T

S

G

G

I

I

Y

S

V

V

L

L

E

H

P

P

E

A

V

L

I

F

D

E

L

G

V

C

P

Q

P

A

G

G

E

-

A

A

F

F

D

-

I

-

G

-

S

-

Q

K

L

L

F

A

P

P

M

L

L

L

V

R

E

Q

K

A

S

M

L

A

P

A

F

G

F

K

A

V

Q

S

K

G

R

E

F

H

F

Y

-

R

-

G

N

H

W

W

I

V

D
|
D

I

V

G

G

R

T

L

L

GER 11:13 (≠ GTR 12:14) binding UTP
K23 (= K24) binding UTP
N105 (≠ C117) binding substrate
D107 (= D119) binding Mg(2+)
D140 (≠ Q151) binding substrate
D205 (= D232) binding Mg(2+); binding substrate

O22287 Mannose-1-phosphate guanylyltransferase 1; GDP-mannose pyrophosphorylase 1; Protein CYTOKINESIS DEFECTIVE 1; Protein EMBRYO DEFECTIVE 101; Protein HYPERSENSITIVE TO AMMONIUM ION 1; Protein SENSITIVE TO OZONE 1; Protein VITAMIN C DEFECTIVE 1; EC 2.7.7.13 from Arabidopsis thaliana (Mouse-ear cress) (see 5 papers)
28% identity, 96% coverage: 3:356/367 of query aligns to 2:336/361 of O22287

query
sites
O22287

K

K

G

A

M

L

I

I

L
|
L

A
x
V

A

G

G
|
G

Q

F

G
|
G

T
|
T

R
|
R

V

L

R

R

P

P

L

L

T

T

K

L

Y

S

L

F

P
|
P

K
|
K

P

P

M

L

V

V

P
x
D

I

F

L

A

G

N

K

K

P

P

V

M

L

I

E

L

Y

H

L

Q

I

I

E

E

H

A

L

L

A

K

R

A

Y

V

G

G

V

V

D

D

E

E

I

V

M

V

I

L

N

A

V

I

A

N

Y

Y

N

Q

H

P

Y

E

K

V

I

M

E

L

D

N

Y

F

F

L

G

K

D

D

G

F

H

E

-

T

R

K

W

L

G

E

V

I

Q

K

I

I

G

T

Y

C

S

S

Y

Q

E

E

G

T

V

-

R

-

E

-

H

-

G

-

E

-

V

-

P

-

R

E

P

P

L

L

G
|
G

S

T

A

A

G

G

G
x
P

M

L

R

A

-

L

-

A

-

R

-

D

K

K

I

L

Q

L

D

D

F

G

S

S

G

G

-

E

-

P

F

F

D

-

Q

-

T

-

L

-

V

V

V

L

C
x
N

G

S

D
|
D

A

V

I

I

V

S

D

E

L

Y

D

P

I

L

R

K

A

E

A

M

L

L

D

E

E

F

H

H

R

K

L

S

K

H

G

G

A

G

L

E

A

A

S

S

V

I

I

M

T

V

L

T

E

K

V

V

P

-

R

-

E

D

Q

E

V

P

Q

S

N

K

Y

Y

G
|
G

V

V

A

M

-

E

D

E

G

S

D

T

G

G

R

R

V

V

L

E

S

K

F

F

Q

V

E

E

K

K

P

-

S

-

P

P

E

K

A

L

A

Y

L

V

S

G

T

N

H

K

A

I

S
x
N

T

A

G

G

I

I

Y

Y

V

L

L

L

E

N

P

P

E

S

V

V

I

L

D

D

L

K

V

I

P

-

G

-

E

-

A

-

F

-

D

-

I

-

G

-

S

-

Q

E

L

L

F

R

P

P

M

T

L

S

V

I

E

E

K

K

-

E

S

T

L

F

P

P

F

K

F

I

A

A

Q

A

K

A

R

Q

F

G

F

L

N

Y

-

A

-

M

-

V

-

L

-

P

-

G

-

F

W

W

I

M

D

D

I

I

G

G

R

Q

L
x
P

S
x
R

D
|
D

Y
|
Y

W
x
I

S
x
T

V
x
G

L
|
L

Q
x
R

-
x
L

-
x
Y

-
x
L

R
x
D

V
x
S

L
|
L

R
|
R

G
x
K

E
x
K

V
x
S

A
x
P

Q
x
A

M
x
K

D
x
L

M
x
T

P
x
S

G
|
G

R
x
P

E
x
H

V
x
I

R
x
V

P
x
G

G
x
N

V
|
V

W
x
L

V
|
V

G
x
D

L
x
E

N
x
T

T
x
A

S
x
T

I
|
I

A
x
G

W
x
E

E
x
G

S
x
C

V

-

Q

-

I
x
L

V
x
I

G
|
G

P
|
P

-
x
D

V
|
V

H
x
A

I
|
I

G
|
G

S
x
P

G
|
G

V
x
C

R
x
I

I
x
V

E
|
E

P
x
S

G
|
G

A
x
V

S
x
R

V

-

I
x
L

G
x
S

P
x
R

S
x
C

W
x
T

I
x
V

G
x
M

H
x
R

G
|
G

S
x
V

H
x
R

L
x
I

R
x
K

P
x
K

G
x
H

A
|
A

R
x
C

V
x
I

E
x
S

R
x
S

S
|
S

I
|
I

L
x
I

F
x
G

P
x
W

Y
x
H

T
x
S

R
x
T

I
x
V

G
|
G

E
x
Q

G
x
W

Q
x
A

R
|
R

F
x
I

I
x
E

D
x
N

K
x
M

I
x
T

V
x
I

S

-

P

-

Q

-

Y

-

C

-

V

-

D

-

R

-

S
x
L

G
|
G

E
|
E

T
x
D

L
x
V

Y
x
H

V
|
V

G
x
S

D
|
D

D
x
E

L6 (= L7) binding GDP-alpha-D-mannose
V7 (≠ A8) binding GDP-alpha-D-mannose
G9 (= G10) binding diphosphate
G11 (= G12) binding diphosphate; mutation to S: In hsn1; reduced enzyme activity, ascorbate concentrations and N-glycosylation, and increased sensitivity to ammonium.
T12 (= T13) binding diphosphate
R13 (= R14) binding diphosphate
P22 (= P23) mutation to S: In vtc1-1 and vtc1-2; reduced enzyme activity and ascorbate concentrations, and ozone-sensitive.
K23 (= K24) binding diphosphate
D27 (≠ P28) mutation to E: Abolishes interaction with CSN5B and subsequent degradation in the dark by the 26S proteasome, and increases ascorbate accumulation in seedlings.
G85 (= G94) binding GDP-alpha-D-mannose
P89 (≠ G98) mutation to L: In cyt1-1; deficient in N-glycosylation and cellulose, and embryo lethal.
N109 (≠ C117) binding GDP-alpha-D-mannose
D111 (= D119) binding GDP-alpha-D-mannose
G146 (= G156) binding GDP-alpha-D-mannose
N173 (≠ S184) binding GDP-alpha-D-mannose

Sites not aligning to the query:

223:361 mutation Missing: Reduces catalytic activity 3-fold.

7x8kB Arabidopsis gdp-d-mannose pyrophosphorylase (vtc1) structure (product- bound) (see paper)
28% identity, 96% coverage: 3:356/367 of query aligns to 2:336/367 of 7x8kB

query
sites
7x8kB

K

K

G

A

M

L

I

I

L

L

A

V

A

G

G
|
G

Q
x
F

G
|
G

T
|
T

R

R

V

L

R

R

P

P

L

L

T

T

K

L

Y

S

L

F

P

P

K
|
K

P

P

M

L

V

V

P

D

I

F

L

A

G

N

K

K

P

P

V

M

L

I

E

L

Y

H

L

Q

I

I

E

E

H

A

L

L

A

K

R

A

Y

V

G

G

V

V

D

D

E

E

I

V

M

V

I

L

N

A

V

I

A

N

Y

Y

N

Q

H

P

Y

E

K

V

I

M

E

L

D

N

Y

F

F

L

G

K

D

D

G

F

H

E

-

T

R

K

W

L

G

E

V

I

Q

K

I

I

G

T

Y

C

S

S

Y

Q

E

E

G

T

V

-

R

-

E

-

H

-

G

-

E

-

V

-

P

-

R

E

P

P

L

L

G

G

S

T

A

A

G

G

G

P

M

L

R

A

-

L

-

A

-

R

-

D

K

K

I

L

Q

L

D

D

F

G

S

S

G

G

-

E

-

P

F

F

D

-

Q

-

T

-

L

-

V

V

V

L

C

N

G

S

D

D

A

V

I

I

V

S

D

E

L

Y

D

P

I

L

R

K

A

E

A

M

L

L

D

E

E

F

H

H

R

K

L

S

K

H

G

G

A

G

L

E

A

A

S

S

V

I

I

M

T

V

L

T

E

K

V

V

P

-

R

-

E

D

Q

E

V

P

Q

S

N

K

Y

Y

G

G

V

V

A

M

-

E

D

E

G

S

D

T

G

G

R

R

V

V

L

E

S

K

F

F

Q

V

E

E

K

K

P

-

S

-

P

P

E

K

A

L

A

Y

L

V

S

G

T

N

H

K

A

I

S

N

T

A

G

G

I

I

Y

Y

V

L

L

L

E

N

P

P

E

S

V

V

I

L

D

D

L

K

V

I

P

-

G

-

E

-

A

-

F

-

D

-

I

-

G

-

S

-

Q

E

L

L

F

R

P

P

M

T

L

S

V

I

E

E

K

K

-

E

S

T

L

F

P

P

F

K

F

I

A

A

Q

A

K

A

R

Q

F

G

F

L

N

Y

-

A

-

M

-

V

-

L

-

P

-

G

-

F

W

W

I

M

D

D

I

I

G

G

R

Q

L

P

S

R

D

D

Y

Y

W

I

S

T

V

G

L

L

Q

R

-

L

-

Y

-

L

R

D

V

S

L

L

R

R

G

K

E

K

V

S

A

P

Q

A

M

K

D

L

M

T

P

S

G

G

R

P

E

H

V

I

R

V

P

G

G

N

V

V

W

L

V

V

G

D

L

E

N

T

T

A

S

T

I

I

A

G

W

E

E

G

S

C

V

-

Q

-

I

L

V

I

G

G

P

P

-

D

V

V

H

A

I

I

G

G

S

P

G

G

V

C

R

I

I

V

E

E

P

S

G

G

A

V

S

R

V

-

I

L

G

S

P

R

S

C

W

T

I

V

G

M

H

R

G

G

S

V

H

R

L

I

R

K

P

K

G

H

A

A

R

C

V

I

E

S

R

S

S

S

I

I

L

I

F

G

P

W

Y

H

T

S

R

T

I

V

G

G

E

Q

G

W

Q

A

R

R

F

I

I

E

D

N

K

M

I

T

V

I

S

-

P

-

Q

-

Y

-

C

-

V

-

D

-

R

-

S

L

G

G

E

E

T

D

L

V

Y

H

V

V

G

S

D

D

D

E

binding pyrophosphate: G9 (= G10), F10 (≠ Q11), G11 (= G12), T12 (= T13), K23 (= K24)

7x8kA Arabidopsis gdp-d-mannose pyrophosphorylase (vtc1) structure (product- bound) (see paper)
28% identity, 96% coverage: 3:356/367 of query aligns to 2:335/365 of 7x8kA

query
sites
7x8kA

K

K

G

A

M

L

I

I

L

L

A
x
V

A
x
G

G

G

Q

F

G

G

T

T

R

R

V

L

R

R

P

P

L

L

T

T

K

L

Y

S

L

F

P

P

K

K

P

P

M

L

V

V

P

D

I

F

L

A

G

N

K

K

P

P

V

M

L

I

E

L

Y

H

L

Q

I

I

E

E

H

A

L

L

A

K

R

A

Y

V

G

G

V

V

D

D

E

E

I

V

M

V

I

L

N

A

V

I

A

N

Y

Y

N

Q

H

P

Y

E

K

V

I

M

E

L

D

N

Y

F

F

L

G

K

D

D

G

F

H

E

-

T

R

K

W

L

G

E

V

I

Q

K

I

I

G

T

Y

C

S

S

Y

Q

E
|
E

G

-

V

-

R

-

E

-

H

-

G

-

E

-

V

-

P

T

R

E

P

P

L

L

G
|
G

S

T

A

A

G

G

G
x
P

M

L

R

A

-

L

-

A

-

R

-

D

K

K

I

L

Q

L

D

D

F

G

S

S

G

G

-

E

-

P

F

F

D

-

Q

-

T

-

L

-

V

V

V

L

C
x
N

G

S

D
|
D

A

V

I

I

V

S

D

E

L

Y

D

P

I

L

R

K

A

E

A

M

L

L

D

E

E

F

H

H

R

K

L

S

K

H

G

G

A

G

L

E

A

A

S

S

V

I

I

M

T

V

L

T

E

K

V

V

P

-

R

-

E

D

Q

E

V

P

Q

S

N

K

Y

Y

G
|
G

V

V

A

M

-

E

D

E

G

S

D

T

G

G

R

R

V

V

L

E

S

K

F

F

Q

V

E
|
E

K

K

P

P

S

-

P

-

E

-

A

L

A

Y

L

V

S

G

T

N

H

K

A

I

S
x
N

T

A

G
|
G

I

I

Y

Y

V

L

L

L

E

N

P

P

E

S

V

V

I

L

D

D

L

K

V

I

P

-

G

-

E

-

A

-

F

-

D

-

I

-

G

-

S

-

Q

E

L

L

F

R

P

P

M

T

L

S

V

I

E
|
E

K

K

-

E

S

T

L

F

P

P

F

K

F

I

A

A

Q

A

K

A

R

Q

F

G

F

L

N

Y

-

A

-

M

-

V

-

L

-

P

-

G

-

F

W

W

I

M

D

D

I

I

G

G

R

Q

L

P

S

R

D

D

Y

Y

W

I

S

T

V

G

L

L

Q

R

-

L

-

Y

-

L

R

D

V

S

L

L

R

R

G

K

E

K

V

S

A

P

Q

A

M

K

D

L

M

T

P

S

G

G

R

P

E

H

V

I

R

V

P

G

G

N

V

V

W

L

V

V

G

D

L

E

N

T

T

A

S

T

I

I

A

G

W

E

E

G

S

C

V

-

Q

-

I

L

V

I

G

G

P

P

-

D

V

V

H

A

I

I

G

G

S

P

G

G

V

C

R

I

I

V

E

E

P

S

G

G

A

V

S

R

V

-

I

L

G

S

P

R

S

C

W

T

I

V

G

M

H

R

G

G

S

V

H

R

L

I

R

K

P

K

G

H

A

A

R

C

V

I

E

S

R

S

S

S

I

I

L

I

F

G

P

W

Y

H

T

S

R

T

I

V

G

G

E

Q

G

W

Q

A

R

R

F

I

I

E

D

N

K

M

I

T

V

I

S

-

P

-

Q

-

Y

-

C

-

V

-

D

-

R

-

S

L

G

G

E

E

T

D

L

V

Y

H

V

V

G

S

D

D

D

E

binding guanosine-5'-diphosphate-alpha-d-mannose: V7 (≠ A8), G8 (≠ A9), E80 (= E80), G85 (= G94), P89 (≠ G98), N109 (≠ C117), D111 (= D119), G146 (= G156), E162 (= E171), N172 (≠ S184), G174 (= G186), E194 (= E216)

6n0uA Crystal structure of a glucose-1-phosphate thymidylyltransferase from burkholderia phymatum bound to 2'-deoxy-thymidine-b-l-rhamnose
30% identity, 63% coverage: 3:234/367 of query aligns to 5:228/295 of 6n0uA

query
sites
6n0uA

K

K

G

G

M

I

I

I

L
|
L

A

A

A
x
G

G
|
G

Q

S

G

G

T

T

R

R

V

L

R

Y

P

P

L

I

T

T

K

H

Y

V

L

V

P

S

K

K

P

Q

M

L

V

L

P

P

I

V

L

Y

G

D

K

K

P

P

V

M

L

I

E

Y

Y

Y

L

P

I

L

E

S

H

T

L

L

A

M

R

V

Y

A

G

G

V

I

-

R

D

D

E

V

I

L

M

I

I

I

N

S

V

T

A

P

Y

Q

N

D

H

T

Y

P

K

R

I

F

E

E

D

A

Y

M

F

L

G

G

D

D

G

G

H

S

R

Q

W

W

G

G

V

M

Q

N

I

I

G

Q

Y

Y

S

A

Y

-

E

-

G

-

V

-

R

-

E

-

H

-

G

-

E

-

V

V

V
x
Q

P

P

R

S

P
|
P

L

D

G
|
G

S
x
L

A

A

G

Q

G

A

M

F

R

I

K

I

I

G

Q

R

D

E

F

F

S

V

G

G

F

-

F

N

D

D

Q

P

T

S

T

A

L

L

V

I

V
x
L

C

G

G
x
D

D

N

A

I

I

F

V

Y

D

G

L

H

D

D

I

L

R

A

A

K

A

Q

L

L

D

E

E

R

H

A

R

N

L

A

K

R

G

T

A

D

L

G

A

A

S

T

V

V

I

F

T

A

L

Y

E

H

V

V

P

-

R

-

E

H

Q

D

V

P

Q

E

N

R

Y
|
Y

G
|
G

V

V

V

E

A

F

D

D

G

K

D

D

G

F

R

R

V

A

L

L

S

S

F

I

Q

E

E
|
E

K
|
K

P

P

S

A

P

K

E

P

A

R

A

-

L

-

S

S

T

N

H

Y

A

A

S
x
V

T

T

G
|
G

I

L

Y
|
Y

V

F

L

Y

E

D

P

N

E

Q

V

V

I

C

D

D

L

I

-

A

-

D

V

I

P

K

P

P

G

S

-

A

-
x
R

-

G

-

E

-

L

E

E

A

I

F

T

D

D

I

V

G

N

S

S

Q

R

L

-

F

-

P

-

M

Y

L

L

V

S

E

Q

K

K

S

T

L

L

P

D

F

V

F

E

A

I

Q

M

K

G

R

R

F

G

F

Y

N

A

W

W

I

L

D

D

I

T

G

G

binding 2'-deoxy-thymidine-beta-l-rhamnose: L9 (= L7), G11 (≠ A9), G12 (= G10), Q83 (≠ V89), P86 (= P92), G88 (= G94), L89 (≠ S95), L109 (≠ V116), D111 (≠ G118), Y146 (= Y155), G147 (= G156), E162 (= E171), K163 (= K172), V173 (≠ S184), G175 (= G186), Y177 (= Y188), R195 (vs. gap)

Q8Z5I4 Glucose-1-phosphate cytidylyltransferase; CDP-glucose pyrophosphorylase; EC 2.7.7.33 from Salmonella typhi (see 2 papers)
30% identity, 53% coverage: 3:198/367 of query aligns to 2:200/257 of Q8Z5I4

query
sites
Q8Z5I4

K

K

G

A

M

V

I

I

L

L

A

A

A

G

G

G

Q

L

G

G

T

T

R

R

V

L

R

S

P

E

L

E

T

T

K

I

Y

V

L

K

P

P

K
|
K

P

P

M

M

V

V

P

E

I

I

L

G

G

G

K

K

P

P

V

I

L

L

E

W

Y

H

L

I

I

M

E

K

H

M

L

Y

A

S

R

V

Y

H

G

G

V

I

D

K

E

D

I

F

M

I

I

I

N

C

V

C

A

G

Y

Y

N

K

H

G

Y

Y

K

V

I

I

E

K

D

E

Y

Y

F

F

G

A

D

N

G

Y

H

F

R

L

W

H

G

M

V

S

Q

D

I

V

G

T

Y

F

S

H

Y

M

E

A

G

E

V

N

R

R

-

M

-

E

-

V

E

H

H

H

G

K

E

R

V

V

V

E

P

P

R

W

P

N

L

V

G

T

-

L

-

V

-

D

-

T

-

G

-

D

-

S

-
x
S

-

M

S

T

A

G

G

G

G
x
R

M

L

R

K

K

R

I

V

Q

A

D

E

F

Y

S

V

G

K

F

-

F

D

D

D

Q

E

T

A

T

F

L

L

V

F

V

T

C

Y

G
|
G

D
|
D

A

G

I

V

V

A

D

D

L

L

D

D

I

I

R

K

A

A

A

T

L

I

D

D

E

F

H

H

R

K

L

A

K

H

G

G

A

K

L

K

A

A

S

T

V

L

I

T

T

A

L

T

E

F

V

P

P

P

R

-

E

-

Q

-

V

-

Q

G

N

R

Y

F

G

G

V

A

V

L

V

D

A

I

D

Q

G

A

D

-

G

G

R

Q

V

V

L

R

S

S

F

F

Q

Q

E

E

K

K

P

P

S

K

P

G

E

D

A

G

A

A

L

M

S

-

T

-

H

-

A

I

S

N

T

G

G

G

I

F

Y

F

V

V

L

L

E

N

P

P

E

S

V

V

I

I

D

D

L

L

V

I

K23 (= K24) binding substrate
S104 (vs. gap) binding substrate
R109 (≠ G98) binding substrate
G128 (= G118) binding substrate
D129 (= D119) binding Mg(2+)

Sites not aligning to the query:

234 binding Mg(2+)

5ifyA Crystal structure of glucose-1-phosphate thymidylyltransferase from burkholderia vietnamiensis in complex with 2 -deoxyuridine-5'- monophosphate and 2'-deoxy-thymidine-b-l-rhamnose
29% identity, 63% coverage: 3:234/367 of query aligns to 3:226/293 of 5ifyA

query
sites
5ifyA

K

K

G

G

M

I

I

I

L
|
L

A

A

A
x
G

G

G

Q

S

G

G

T

T

R

R

V

L

R

Y

P

P

L

I

T

T

K

H

Y

A

L

V

P

S

K

K

P

Q

M

L

V

L

P

P

I

V

L

Y

G

D

K

K

P

P

V

M

L

I

E

Y

Y

Y

L

P

I

L

E

S

H

T

L

L

A

M

R

I

Y

A

G

G

V

I

-

R

D

D

E

V

I

L

M

I

I

I

N

S

V

T

A

P

Y

Q

N

D

H

T

Y

P

K

R

I

F

E

E

D

S

Y

M

F

L

G

G

D

D

G

G

H

S

R

Q

W

W

G

G

V

M

Q

N

I

I

G

Q

Y

Y

S

A

Y

T

E
x
Q

G

-

V

-

R

-

E

-

H

-

G

-

E

-

V

-

P

P

R

S

P
|
P

L

D

G
|
G

S
x
L

A

A

G

Q

G

A

M

F

R

V

K

I

I

G

Q

R

D

D

F

F

S

V

G

G

F

-

D

N

Q

E

T

P

T

S

L

A

V

L

V

I

C

L

G

G

D
|
D

A

N

I

I

V

F

-
x
Y

D
x
G

L
x
H

D
|
D

I

L

R

A

A

K

A

Q

L

L

D

E

E

R

H

A

R

S

L

A

K

K

G

D

A

T

L

G

A

A

S

T

V

V

I

F

T

A

L

Y

E

H

V

V

P

-

R

-

E

Q

Q

D

V

P

Q

E

N

R

Y
|
Y

G
|
G

V

V

V

E

A

F

D

D

G

R

D

E

G

F

R

R

V

A

L

I

S

S

F

I

Q

E

E
|
E

K
|
K

P

P

S

A

P

K

E

P

A

R

A

-

L

-

S

S

T

S

H

Y

A

A

S
x
V

T

T

G

G

I

L

Y
|
Y

V

F

L

Y

E

D

P

R

E

Q

V

V

I

C

D

D

L

I

-

A

-

D

V

I

P

K

P

P

G

S

-

A

-
x
R

-

G

-

E

-

L

E

E

A

I

F

T

D

D

I

V

G

N

S

S

Q

R

L

-

F

-

P

-

M

Y

L

L

V

A

E

A

K

G

S

Q

L

L

P

D

F

V

F

E

A

L

Q

M

K
x
G

R
|
R

F
x
G

F

Y

N

A

W

W

I

L

D

D

I

T

G

G

binding 2'-deoxy-thymidine-beta-l-rhamnose: L7 (= L7), G9 (≠ A9), Q81 (≠ E80), P84 (= P92), G86 (= G94), L87 (≠ S95), D109 (= D119), Y144 (= Y155), G145 (= G156), E160 (= E171), K161 (= K172), V171 (≠ S184), Y175 (= Y188), R193 (vs. gap)
binding 2'-deoxyuridine 5'-monophosphate: Y113 (vs. gap), G114 (≠ D123), H115 (≠ L124), D116 (= D125), G217 (≠ K225), R218 (= R226), G219 (≠ F227)

Sites not aligning to the query:

binding 2'-deoxyuridine 5'-monophosphate: 254, 255

4b2xB Pseudomonas aeruginosa rmla in complex with allosteric inhibitor (see paper)
30% identity, 63% coverage: 3:234/367 of query aligns to 13:236/302 of 4b2xB

query
sites
4b2xB

K

K

G

G

M

I

I

I

L

L

A

A

A

G

G

G

Q

S

G

G

T

T

R

R

V

L

R

H

P

P

L

A

T

T

K

L

Y

A

L

I

P

S

K

K

P

Q

M

L

V

L

P

P

I

V

L

Y

G

D

K

K

P

P

V

M

L

I

E

Y

Y

Y

L

P

I

L

E

S

H

T

L

L

A

M

R
x
L

Y

A

G

G

V

I

D

R

E

E

I

I

M

L

-

I

I

I

N

S

V

T

A

P

Y

Q

N

D

H

T

Y

P

K

R

I

F

E

Q

D

Q

Y

L

F

L

G

G

D

D

G

G

H

S

R

N

W

W

G

G

V

L

Q

D

I

L

G

Q

Y

Y

S

A

Y

-

E

-

G

-

V

-

R

-

E

-

H

-

G

-

E

-

V

V

V

Q

P

P

R

S

P

P

L

D

G

G

S

L

A

A

G

Q

G

A

M

F

R

L

K

I

I

G

Q

E

D

S

F

F

S

I

G

G

F

-

F

N

D

D

Q

L

T

S

T

A

L

L

V

V

V

L

C

G

G

D

D

N

A

L

I
x
Y

V

Y

D

G

L

H

D

D

I

F

R

H

A

E

A

L

L

L

D

G

E

S

H

A

R

S

L

Q

K

R

G

Q

A

T

L

G

A

A

S

S

V

V

I

F

T

A

L

Y

E

H

V

V

P

L

R

-

E

-

Q

D

V

P

Q

E

N

R

Y

Y

G

G

V

V

V

E

A

F

D

D

G

Q

D

G

G

G

R

K

V

A

L

I

S

S

F

L

Q

E

E

E

K

K

P

P

-

L

S

E

P

P

E

K

A

-

L

-

S

S

T

N

H

Y

A

A

S

V

T

T

G

G

I

L

Y

Y

V

F

L

Y

E

D

P

Q

E

Q

V

V

I

V

D

D

L

I

V

A

-

R

-

D

-

L

-

K

-

P

-

S

P

P

P

R

G

G

E

E

A

-

F

L

D

E

I

I

G

T

S

D

Q

V

L

N

F

R

P

A

M

Y

L

L

V

E

E

R

K

G

S

Q

L

L

P

S

F

V

F

E

A

I

Q

M

K

G

R

R

F

G

F

Y

N

A

W

W

I

L

D

D

I

T

G

G

binding 6-amino-1-butyl-5-(cyclopentylamino)pyrimidine-2,4(1H,3H)-dione: L54 (≠ R44), Y122 (≠ I121)

Sites not aligning to the query:

binding 6-amino-1-butyl-5-(cyclopentylamino)pyrimidine-2,4(1H,3H)-dione: 264, 269

4b4mA Pseudomonas aeruginosa rmla in complex with allosteric inhibitor (see paper)
30% identity, 63% coverage: 3:234/367 of query aligns to 7:230/296 of 4b4mA

query
sites
4b4mA

K

K

G

G

M

I

I

I

L

L

A

A

A

G

G

G

Q

S

G

G

T

T

R

R

V

L

R

H

P

P

L

A

T

T

K

L

Y

A

L

I

P

S

K

K

P

Q

M

L

V

L

P

P

I

V

L

Y

G

D

K

K

P

P

V

M

L

I

E

Y

Y

Y

L

P

I

L

E
x
S

H
x
T

L

L

A

M

R
x
L

Y

A

G

G

V

I

D

R

E

E

I

I

M

L

-

I

I

I

N

S

V

T

A

P

Y

Q

N

D

H

T

Y

P

K

R

I

F

E

Q

D

Q

Y

L

F

L

G

G

D

D

G

G

H

S

R

N

W

W

G

G

V

L

Q

D

I

L

G

Q

Y

Y

S

A

Y

-

E

-

G

-

V

-

R

-

E

-

H

-

G

-

E

-

V

V

V

Q

P

P

R

S

P

P

L

D

G

G

S

L

A

A

G

Q

G

A

M

F

R

L

K

I

I

G

Q

E

D

S

F

F

S

I

G

G

F

-

F

N

D

D

Q

L

T

S

T

A

L

L

V

V

V

L

C

G

G

D

D

N

A

L

I
x
Y

V

Y

D
x
G

L

H

D

D

I

F

R

H

A

E

A

L

L

L

D

G

E

S

H

A

R

S

L

Q

K

R

G

Q

A

T

L

G

A

A

S

S

V

V

I

F

T

A

L

Y

E

H

V

V

P

L

R

-

E

-

Q

D

V

P

Q

E

N

R

Y

Y

G

G

V

V

V

E

A

F

D

D

G

Q

D

G

G

G

R

K

V

A

L

I

S

S

F

L

Q

E

E

E

K

K

P

P

-

L

S

E

P

P

E

K

A

-

L

-

S

S

T

N

H

Y

A

A

S

V

T

T

G

G

I

L

Y

Y

V

F

L

Y

E

D

P

Q

E

Q

V

V

I

V

D

D

L

I

V

A

-

R

-

D

-

L

-

K

-

P

-

S

P

P

P

R

G

G

E

E

A

-

F

L

D

E

I

I

G

T

S

D

Q

V

L

N

F

R

P

A

M

Y

L

L

V

E

E

R

K

G

S

Q

L

L

P

S

F

V

F

E

A

I

Q

M

K

G

R

R

F

G

F

Y

N

A

W

W

I

L

D

D

I

T

G

G

binding N-(6-amino-1-benzyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-4-fluoro-N-methylbenzenesulfonamide: S44 (≠ E40), T45 (≠ H41), L48 (≠ R44), Y116 (≠ I121), G118 (≠ D123)

Sites not aligning to the query:

binding N-(6-amino-1-benzyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-4-fluoro-N-methylbenzenesulfonamide: 253, 254, 258, 259, 262

6t37A Pseudomonas aeruginosa rmla in complex with allosteric inhibitor (see paper)
30% identity, 63% coverage: 3:234/367 of query aligns to 3:223/289 of 6t37A

query
sites
6t37A

K

K

G

G

M

I

I

I

L

L

A

A

A

G

G

G

Q

S

G

G

T

T

R

R

V

L

R

H

P

P

L

A

T

T

K

L

Y

A

L

I

P

S

K

K

P

Q

M

L

V

L

P

P

I

V

L

Y

G

D

K

K

P

P

V

M

L

I

E

Y

Y

Y

L

P

I

L

E
x
S

H

T

L

L

A

M

R
x
L

Y

A

G

G

V

I

D

R

E

E

I

I

M

L

-

I

I

I

N

S

V

T

A

P

Y

Q

N

D

H

T

Y

P

K

R

I

F

E

Q

D

Q

Y

L

F

L

G

G

D

D

G

G

H

S

R

N

W

W

G

G

V

L

Q

D

I

L

G

Q

Y

Y

S

A

Y

-

E

-

G

-

V

-

R

-

E

-

H

-

G

-

E

-

V

V

V

Q

P

P

R

S

P

P

L

D

G

G

S

L

A

A

G

Q

G

A

M

F

R

L

K

I

I

G

Q

E

D

S

F

F

S

I

G

G

F

-

F

N

D

D

Q

L

T

S

T

A

L

L

V

V

V

L

C

G

G

D

D

N

A

L

I
x
Y

V

Y

D
x
G

L

H

D

D

I

F

R
x
H

A

E

A

L

L

L

D

G

E

S

H

A

R

S

L

Q

K

R

G

Q

A

T

L

G

A

A

S

S

V

V

I

F

T

A

L

Y

E

H

V

V

P

L

R

D

E

P

Q

-

V

-

Q

E

N

R

Y

Y

G

G

V

V

V

E

A

F

D

D

G

Q

D

G

G

G

R

K

V

A

L

I

S

S

F

L

Q

E

E

E

K

K

P

P

-

L

S

E

P

P

E

K

A

-

L

-

S

S

T

N

H

Y

A

A

S

V

T

T

G

G

I

L

Y

Y

V

F

L

Y

E

D

P

Q

E

Q

V

V

I

V

D

D

L

I

-

A

-

R

-

D

V

L

P

K

P

P

G

S

E

E

A

-

F

L

D

E

I

I

G

T

S

D

Q

V

L

N

F

R

P

A

M

Y

L

L

V

E

E

R

K

G

S

Q

L

L

P

S

F

V

F

E

A

I

Q

M

K

G

R

R

F

G

F

Y

N

A

W

W

I

L

D

D

I

T

G

G

binding ~{N}-[6-[3-[4-(aminomethyl)-1,2,3-triazol-1-yl]propylamino]-2,4-bis(oxidanylidene)-1-(phenylmethyl)pyrimidin-5-yl]-~{N}-methyl-benzenesulfonamide: S40 (≠ E40), L44 (≠ R44), Y112 (≠ I121), G114 (≠ D123), H118 (≠ R127)

Sites not aligning to the query:

binding ~{N}-[6-[3-[4-(aminomethyl)-1,2,3-triazol-1-yl]propylamino]-2,4-bis(oxidanylidene)-1-(phenylmethyl)pyrimidin-5-yl]-~{N}-methyl-benzenesulfonamide: 246, 251, 252, 255

4arwA Pseudomonas aeruginosa rmla in complex with allosteric inhibitor (see paper)
30% identity, 63% coverage: 3:234/367 of query aligns to 5:228/294 of 4arwA

query
sites
4arwA

K

K

G

G

M

I

I

I

L

L

A

A

A

G

G

G

Q

S

G

G

T

T

R

R

V

L

R

H

P

P

L

A

T

T

K

L

Y

A

L

I

P

S

K

K

P

Q

M

L

V

L

P

P

I

V

L

Y

G

D

K

K

P

P

V

M

L

I

E

Y

Y

Y

L

P

I

L

E
x
S

H

T

L

L

A

M

R
x
L

Y

A

G

G

V

I

D

R

E

E

I

I

M

L

-

I

I

I

N

S

V

T

A

P

Y

Q

N

D

H

T

Y

P

K

R

I

F

E

Q

D

Q

Y

L

F

L

G

G

D

D

G

G

H

S

R

N

W

W

G

G

V

L

Q

D

I

L

G

Q

Y

Y

S

A

Y

-

E

-

G

-

V

-

R

-

E

-

H

-

G

-

E

-

V

V

V

Q

P

P

R

S

P

P

L

D

G

G

S

L

A

A

G

Q

G

A

M

F

R

L

K

I

I

G

Q

E

D

S

F

F

S

I

G

G

F

-

F

N

D

D

Q

L

T

S

T

A

L

L

V

V

V

L

C

G

G

D

D

N

A

L

I
x
Y

V
x
Y

D
x
G

L

H

D

D

I

F

R

H

A

E

A

L

L

L

D

G

E

S

H

A

R

S

L

Q

K

R

G

Q

A

T

L

G

A

A

S

S

V

V

I

F

T

A

L

Y

E

H

V

V

P

L

R

-

E

-

Q

D

V

P

Q

E

N

R

Y

Y

G

G

V

V

V

E

A

F

D

D

G

Q

D

G

G

G

R

K

V

A

L

I

S

S

F

L

Q

E

E

E

K

K

P

P

-

L

S

E

P

P

E

K

A

-

L

-

S

S

T

N

H

Y

A

A

S

V

T

T

G

G

I

L

Y

Y

V

F

L

Y

E

D

P

Q

E

Q

V

V

I

V

D

D

L

I

V

A

-

R

-

D

-

L

-

K

-

P

-

S

P

P

P

R

G

G

E

E

A

-

F

L

D

E

I

I

G

T

S

D

Q

V

L

N

F

R

P

A

M

Y

L

L

V

E

E

R

K

G

S

Q

L

L

P

S

F

V

F

E

A

I

Q

M

K

G

R

R

F

G

F

Y

N

A

W

W

I

L

D

D

I

T

G

G

binding n-(6-amino-1-butyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-n-methyl-benzenesulfonamide: S42 (≠ E40), L46 (≠ R44), Y114 (≠ I121), Y115 (≠ V122), G116 (≠ D123)

Sites not aligning to the query:

binding n-(6-amino-1-butyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-n-methyl-benzenesulfonamide: 251, 252, 256

5fyeA Pseudomonas aeruginosa rmla in complex with allosteric inhibitor
30% identity, 63% coverage: 3:234/367 of query aligns to 7:230/296 of 5fyeA

query
sites
5fyeA

K

K

G

G

M

I

I

I

L

L

A

A

A

G

G

G

Q

S

G

G

T

T

R

R

V

L

R

H

P

P

L

A

T

T

K

L

Y

A

L

I

P

S

K

K

P

Q

M

L

V

L

P

P

I

V

L

Y

G

D

K

K

P

P

V

M

L

I

E

Y

Y

Y

L

P

I

L

E
x
S

H

T

L

L

A

M

R
x
L

Y

A

G

G

V

I

D

R

E

E

I

I

M

L

-

I

I

I

N

S

V

T

A

P

Y

Q

N

D

H

T

Y

P

K

R

I

F

E

Q

D

Q

Y

L

F

L

G

G

D

D

G

G

H

S

R

N

W

W

G

G

V

L

Q

D

I

L

G

Q

Y

Y

S

A

Y

-

E

-

G

-

V

-

R

-

E

-

H

-

G

-

E

-

V

V

V

Q

P

P

R

S

P

P

L

D

G

G

S

L

A

A

G

Q

G

A

M

F

R

L

K

I

I

G

Q

E

D

S

F

F

S

I

G

G

F

-

F

N

D

D

Q

L

T

S

T

A

L

L

V

V

V

L

C

G

G

D

D

N

A

L

I
x
Y

V

Y

D
x
G

L

H

D

D

I

F

R

H

A

E

A

L

L

L

D

G

E

S

H

A

R

S

L

Q

K

R

G

Q

A

T

L

G

A

A

S

S

V

V

I

F

T

A

L

Y

E

H

V

V

P

L

R

-

E

-

Q

D

V

P

Q

E

N

R

Y

Y

G

G

V

V

V

E

A

F

D

D

G

Q

D

G

G

G

R

K

V

A

L

I

S

S

F

L

Q

E

E

E

K

K

P

P

-

L

S

E

P

P

E

K

A

-

L

-

S

S

T

N

H

Y

A

A

S

V

T

T

G

G

I

L

Y

Y

V

F

L

Y

E

D

P

Q

E

Q

V

V

I

V

D

D

L

I

V

A

-

R

-

D

-

L

-

K

-

P

-

S

P

P

P

R

G

G

E

E

A

-

F

L

D

E

I

I

G

T

S

D

Q

V

L

N

F

R

P

A

M

Y

L

L

V

E

E

R

K

G

S

Q

L

L

P

S

F

V

F

E

A

I

Q

M

K

G

R

R

F

G

F

Y

N

A

W

W

I

L

D

D

I

T

G

G

binding N-(6-Amino-1-(3-fluorobenzyl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-N-methylbenzenesulfonamide: S44 (≠ E40), L48 (≠ R44), Y116 (≠ I121), G118 (≠ D123)

Sites not aligning to the query:

binding N-(6-Amino-1-(3-fluorobenzyl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)-N-methylbenzenesulfonamide: 253, 254, 258, 262

Query Sequence

>WP_011765962.1 NCBI__GCF_000061505.1:WP_011765962.1
MAKGMILAAGQGTRVRPLTKYLPKPMVPILGKPVLEYLIEHLARYGVDEIMINVAYNHYK
IEDYFGDGHRWGVQIGYSYEGVREHGEVVPRPLGSAGGMRKIQDFSGFFDQTTLVVCGDA
IVDLDIRAALDEHRLKGALASVITLEVPREQVQNYGVVVADGDGRVLSFQEKPSPEAALS
THASTGIYVLEPEVIDLVPPGEAFDIGSQLFPMLVEKSLPFFAQKRFFNWIDIGRLSDYW
SVLQRVLRGEVAQMDMPGREVRPGVWVGLNTSIAWESVQIVGPVHIGSGVRIEPGASVIG
PSWIGHGSHLRPGARVERSILFPYTRIGEGQRFIDKIVSPQYCVDRSGETLYVGDDTAAL
RWGDARG

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory