SitesBLAST
Comparing WP_011778591.1 NCBI__GCF_000015305.1:WP_011778591.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
1f3pA Ferredoxin reductase (bpha4)-nadh complex (see paper)
40% identity, 97% coverage: 7:404/412 of query aligns to 7:401/401 of 1f3pA
- active site: L13 (≠ Q13), R44 (= R44), P45 (= P45), Q291 (≠ S300)
- binding flavin-adenine dinucleotide: A14 (≠ T14), V34 (≠ I34), D36 (= D36), E37 (= E37), R44 (= R44), P45 (= P45), A78 (≠ V82), T105 (= T109), G106 (= G110), R126 (= R130), G268 (= G277), D269 (= D278), E285 (= E294), T286 (≠ H295), W287 (≠ F296), A290 (= A299), W316 (= W324)
- binding nicotinamide-adenine-dinucleotide: V147 (≠ I151), G148 (= G152), G150 (= G154), V151 (≠ F155), I152 (= I156), E155 (= E159), E171 (= E175), T172 (≠ A176), R179 (= R183), G230 (= G239), I231 (= I240), G232 (= G241), V233 (≠ I242), E285 (= E294), W316 (= W324), S317 (= S325)
2gr2A Crystal structure of ferredoxin reductase, bpha4 (oxidized form)
40% identity, 97% coverage: 7:404/412 of query aligns to 6:400/401 of 2gr2A
- active site: L12 (≠ Q13), R43 (= R44), P44 (= P45), Q290 (≠ S300)
- binding adenosine-5-diphosphoribose: R109 (= R114), V146 (≠ I151), G147 (= G152), G149 (= G154), V150 (≠ F155), I151 (= I156), E170 (= E175), T171 (≠ A176), R178 (= R183), G229 (= G239), I230 (= I240), G231 (= G241), E284 (= E294)
- binding flavin-adenine dinucleotide: G11 (= G12), A13 (≠ T14), D35 (= D36), E36 (= E37), R43 (= R44), P44 (= P45), K48 (= K49), A77 (≠ V82), T104 (= T109), G105 (= G110), R125 (= R130), G267 (= G277), D268 (= D278), T285 (≠ H295), W286 (≠ F296), A289 (= A299), W315 (= W324)
2gr0A Crystal structure of ferredoxin reductase, bpha4 (oxidized form, NAD+ complex) (see paper)
40% identity, 97% coverage: 7:404/412 of query aligns to 6:400/401 of 2gr0A
- active site: L12 (≠ Q13), R43 (= R44), P44 (= P45), Q290 (≠ S300)
- binding adenosine-5'-diphosphate: V146 (≠ I151), G147 (= G152), G149 (= G154), I151 (= I156), E170 (= E175), T171 (≠ A176), R178 (= R183), G229 (= G239), I230 (= I240), G231 (= G241)
- binding flavin-adenine dinucleotide: G11 (= G12), A13 (≠ T14), D35 (= D36), E36 (= E37), R43 (= R44), P44 (= P45), K48 (= K49), T76 (= T81), A77 (≠ V82), T104 (= T109), G105 (= G110), R125 (= R130), I151 (= I156), G267 (= G277), D268 (= D278), E284 (= E294), T285 (≠ H295), W286 (≠ F296), A289 (= A299), W315 (= W324)
8pxkA Structure of nadh-dependent ferredoxin reductase, bpha4, solved at wavelength 5.76 a (see paper)
40% identity, 97% coverage: 7:404/412 of query aligns to 8:402/403 of 8pxkA
- binding flavin-adenine dinucleotide: G13 (= G12), A15 (≠ T14), D37 (= D36), E38 (= E37), R45 (= R44), P46 (= P45), K50 (= K49), A79 (≠ V82), T106 (= T109), G107 (= G110), R127 (= R130), I153 (= I156), G269 (= G277), D270 (= D278), E286 (= E294), T287 (≠ H295), W288 (≠ F296), A291 (= A299), W317 (= W324)
2yvjA Crystal structure of the ferredoxin-ferredoxin reductase (bpha3- bpha4)complex (see paper)
40% identity, 97% coverage: 7:404/412 of query aligns to 7:401/402 of 2yvjA
- active site: L13 (≠ Q13), R44 (= R44), P45 (= P45), Q291 (≠ S300)
- binding flavin-adenine dinucleotide: G10 (= G10), G12 (= G12), G35 (= G35), D36 (= D36), E37 (= E37), R44 (= R44), P45 (= P45), A78 (≠ V82), T105 (= T109), G106 (= G110), R126 (= R130), G268 (= G277), D269 (= D278), T286 (≠ H295), W287 (≠ F296), A290 (= A299), W316 (= W324)
- binding 1,4-dihydronicotinamide adenine dinucleotide: V147 (≠ I151), G148 (= G152), G149 (≠ A153), G150 (= G154), I152 (= I156), V170 (≠ L174), E171 (= E175), T172 (≠ A176), R179 (= R183), G230 (= G239), I231 (= I240), G232 (= G241), V233 (≠ I242), E285 (= E294)
4h4uA Crystal structure of ferredoxin reductase, bpha4 t176r mutant (reduced form)
40% identity, 97% coverage: 7:404/412 of query aligns to 7:401/401 of 4h4uA
- active site: L13 (≠ Q13), R44 (= R44), P45 (= P45), Q291 (≠ S300)
- binding flavin-adenine dinucleotide: G12 (= G12), A14 (≠ T14), D36 (= D36), R44 (= R44), P45 (= P45), A78 (≠ V82), T105 (= T109), G106 (= G110), L125 (= L129), R126 (= R130), I152 (= I156), E155 (= E159), G268 (= G277), D269 (= D278), E285 (= E294), T286 (≠ H295), W287 (≠ F296), A290 (= A299), W316 (= W324)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: V151 (≠ F155), I152 (= I156), E171 (= E175), R172 (≠ A176), Q173 (≠ V177), G230 (= G239), I231 (= I240), G232 (= G241), I284 (≠ L293), E285 (= E294), Y315 (≠ F323)
4h4wA Crystal structure of ferredoxin reductase, bpha4 e175c/t176r/q177g mutant (reduced form)
40% identity, 96% coverage: 7:401/412 of query aligns to 6:397/399 of 4h4wA
- active site: L12 (≠ Q13), R43 (= R44), P44 (= P45), Q290 (≠ S300)
- binding flavin-adenine dinucleotide: G11 (= G12), A13 (≠ T14), D35 (= D36), R43 (= R44), P44 (= P45), A77 (≠ V82), T104 (= T109), G105 (= G110), R125 (= R130), I151 (= I156), E154 (= E159), G267 (= G277), D268 (= D278), T285 (≠ H295), W286 (≠ F296), A289 (= A299), W315 (= W324)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G148 (≠ A153), I151 (= I156), R171 (≠ A176), S177 (≠ A182), R178 (= R183), G229 (= G239), I230 (= I240), G231 (= G241)
P16640 Putidaredoxin reductase CamA; Pdr; Putidaredoxin--NAD(+) reductase; EC 1.18.1.5 from Pseudomonas putida (Arthrobacter siderocapsulatus) (see 2 papers)
35% identity, 98% coverage: 7:408/412 of query aligns to 8:418/422 of P16640
- A15 (≠ T14) binding FAD
- D37 (= D36) binding FAD
- K50 (= K49) binding FAD
- V83 (= V82) binding FAD
- R134 (= R130) binding FAD
- D284 (= D278) binding FAD
- V302 (≠ F296) binding FAD
1q1wA Crystal structure of putidaredoxin reductase from pseudomonas putida (see paper)
35% identity, 98% coverage: 7:408/412 of query aligns to 7:417/422 of 1q1wA
- active site: L13 (≠ Q13), L44 (≠ R44), P45 (= P45), L305 (≠ S300)
- binding flavin-adenine dinucleotide: G10 (= G10), G12 (= G12), L13 (≠ Q13), A14 (≠ T14), G35 (= G35), D36 (= D36), L44 (≠ R44), P45 (= P45), K49 (= K49), V82 (= V82), A108 (= A108), T109 (= T109), G110 (= G110), R133 (= R130), I159 (= I156), D283 (= D278), S300 (≠ H295), V301 (≠ F296), W329 (= W324)
3fg2P Crystal structure of ferredoxin reductase for the cyp199a2 system from rhodopseudomonas palustris (see paper)
38% identity, 92% coverage: 5:382/412 of query aligns to 3:381/404 of 3fg2P
- binding flavin-adenine dinucleotide: G8 (= G10), G10 (= G12), H11 (≠ Q13), A12 (≠ T14), D34 (= D36), E35 (= E37), R42 (= R44), P43 (= P45), S46 (= S48), K47 (= K49), R78 (≠ T80), M79 (≠ V82), T106 (= T109), R127 (= R130), I153 (= I156), D275 (= D278), S292 (≠ H295), V293 (≠ F296), W321 (= W324)
3lxdA Crystal structure of ferredoxin reductase arr from novosphingobium aromaticivorans (see paper)
38% identity, 88% coverage: 22:382/412 of query aligns to 22:386/409 of 3lxdA
- active site: R44 (= R44), P45 (= P45), N302 (≠ S300)
- binding flavin-adenine dinucleotide: R36 (≠ D36), E37 (= E37), R44 (= R44), P45 (= P45), S48 (= S48), K49 (= K49), E81 (≠ T81), V82 (= V82), T109 (= T109), I157 (= I156), G278 (= G277), D279 (= D278), S297 (≠ H295), V298 (≠ F296), F325 (= F323), W326 (= W324)
Sites not aligning to the query:
6tukB Crystal structure of fdr9 (see paper)
38% identity, 83% coverage: 6:347/412 of query aligns to 4:337/393 of 6tukB
- binding flavin-adenine dinucleotide: V7 (= V9), G8 (= G10), G9 (≠ A11), G10 (= G12), A12 (≠ T14), A34 (≠ D36), E35 (= E37), R42 (= R44), P43 (= P45), K47 (= K49), A75 (≠ D79), A76 (≠ T80), T102 (= T109), G103 (= G110), V118 (≠ L129), R119 (= R130), G259 (= G277), D260 (= D278), H277 (= H295), W278 (≠ F296), F311 (= F323), W312 (= W324)
4emjA Complex between the reductase and ferredoxin components of toluene dioxygenase (see paper)
33% identity, 97% coverage: 9:406/412 of query aligns to 8:406/406 of 4emjA
- binding flavin-adenine dinucleotide: G11 (= G12), V12 (≠ Q13), G13 (≠ T14), D35 (= D36), E36 (= E37), R43 (= R44), P44 (= P45), S47 (= S48), K48 (= K49), V80 (= V82), T107 (= T109), G108 (= G110), R128 (= R130), G274 (= G277), D275 (= D278), T291 (≠ H295), Y292 (≠ F296), S319 (≠ F323), W320 (= W324)
4emiA Toluene dioxygenase reductase in reduced state in complex with NAD+ (see paper)
33% identity, 96% coverage: 9:402/412 of query aligns to 7:401/402 of 4emiA
- binding flavin-adenine dinucleotide: G10 (= G12), V11 (≠ Q13), G12 (≠ T14), D34 (= D36), E35 (= E37), R42 (= R44), P43 (= P45), K47 (= K49), E78 (≠ T81), V79 (= V82), T106 (= T109), G107 (= G110), G273 (= G277), D274 (= D278), T290 (≠ H295), Y291 (≠ F296), W319 (= W324)
- binding nicotinamide-adenine-dinucleotide: R111 (= R114), G149 (= G152), L152 (≠ F155), I153 (= I156), E156 (= E159), E172 (= E175), A173 (= A176), R180 (= R183), V236 (≠ I240), G237 (= G241), A238 (≠ I242), E289 (= E294), W319 (= W324), T320 (≠ S325)
Q9LK94 Monodehydroascorbate reductase 4, peroxisomal; AtMDAR4; EC 1.6.5.4 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
29% identity, 84% coverage: 23:367/412 of query aligns to 25:388/488 of Q9LK94
- G386 (= G365) mutation to Q: In sdp2-3; loss of ascorbate recycling.
Sites not aligning to the query:
- 11 G→Q: In sdp2-2; loss of ascorbate recycling.
- 14 V→A: In sdp2-1; loss of ascorbate recycling.
- 483:488 mutation Missing: Loss of peroxisomal targeting.
- 488 mutation Missing: No effect on peroxisomal targeting.
8c0zE Cryoem structure of a tungsten-containing aldehyde oxidoreductase from aromatoleum aromaticum (see paper)
31% identity, 91% coverage: 7:382/412 of query aligns to 4:388/424 of 8c0zE
5jclA Structure and catalytic mechanism of monodehydroascorbate reductase, mdhar, from oryza sativa l. Japonica (see paper)
28% identity, 84% coverage: 20:367/412 of query aligns to 20:393/429 of 5jclA
- active site: R45 (= R44), P46 (= P45), L61 (vs. gap), H65 (vs. gap), S70 (≠ T55), R317 (≠ S300)
- binding flavin-adenine dinucleotide: S36 (≠ G35), K37 (≠ D36), E38 (= E37), R45 (= R44), P46 (= P45), K50 (= K49), I93 (≠ V82), A119 (= A108), T120 (= T109), G121 (= G110), R144 (= R130), E145 (≠ T131), D295 (= D278), E311 (= E294), H312 (= H295), V313 (≠ F296), A316 (= A299), Y346 (≠ W324)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: G170 (= G154), Y171 (≠ F155), I172 (= I156), E175 (= E159), P192 (≠ A176), R199 (= R183), G256 (= G239), V257 (≠ I240), G258 (= G241), E311 (= E294), H312 (= H295), Y346 (≠ W324)
Sites not aligning to the query:
Q652L6 Monodehydroascorbate reductase 3, cytosolic; OsMDAR3; OsMDHAR3; EC 1.6.5.4 from Oryza sativa subsp. japonica (Rice) (see paper)
28% identity, 84% coverage: 20:367/412 of query aligns to 23:396/435 of Q652L6
- E41 (= E37) binding FAD
- R48 (= R44) binding FAD
- K53 (= K49) binding FAD
- C70 (vs. gap) mutation to A: No effect on catalytic activity.; mutation to S: Slight reduction of catalytic activity.
- G72 (= G54) mutation to N: Slight reduction of catalytic activity.
- I96 (≠ V82) binding FAD
- RE 147:148 (≠ RT 130:131) binding FAD
- 172:178 (vs. 153:159, 71% identical) binding NAD(+)
- YIGLE 174:178 (≠ FIGLE 155:159) binding NADP(+)
- E196 (≠ V177) binding NAD(+); mutation to A: Reduces catalytic activity 2-fold.
- R202 (= R183) binding NAD(+); binding NADP(+)
- G261 (= G241) binding NAD(+); binding NADP(+)
- D298 (= D278) binding FAD
- EH 314:315 (= EH 294:295) binding NAD(+); binding NADP(+)
- V316 (≠ F296) binding FAD
- R320 (≠ S300) binding L-ascorbate; mutation to A: Reduces catalytic activity 5-fold.
- Y349 (≠ W324) binding FAD; binding NAD(+); binding NADP(+); mutation Y->A,F,W: Abolishes catalytic activity.
- R351 (≠ D326) binding L-ascorbate; mutation to A: No effect on catalytic activity.
Sites not aligning to the query:
5jciA Structure and catalytic mechanism of monodehydroascorbate reductase, mdhar, from oryza sativa l. Japonica (see paper)
28% identity, 84% coverage: 20:367/412 of query aligns to 20:393/432 of 5jciA
- active site: R45 (= R44), P46 (= P45), L61 (vs. gap), H65 (vs. gap), S70 (≠ T55), R317 (≠ S300)
- binding flavin-adenine dinucleotide: S36 (≠ G35), K37 (≠ D36), E38 (= E37), R45 (= R44), P46 (= P45), K50 (= K49), I93 (≠ V82), A119 (= A108), T120 (= T109), G121 (= G110), R144 (= R130), E145 (≠ T131), Y171 (≠ F155), I172 (= I156), L262 (≠ N245), D295 (= D278), H312 (= H295), V313 (≠ F296), A316 (= A299), F345 (= F323), Y346 (≠ W324)
Sites not aligning to the query:
5jcnA Structure and catalytic mechanism of monodehydroascorbate reductase, mdhar, from oryza sativa l. Japonica (see paper)
28% identity, 84% coverage: 20:367/412 of query aligns to 20:393/429 of 5jcnA
- active site: R45 (= R44), P46 (= P45), L61 (vs. gap), H65 (vs. gap), S70 (≠ T55), R317 (≠ S300)
- binding ascorbic acid: P46 (= P45), G69 (= G54), R317 (≠ S300), F346 (≠ W324)
- binding flavin-adenine dinucleotide: K37 (≠ D36), E38 (= E37), R45 (= R44), P46 (= P45), K50 (= K49), I93 (≠ V82), A119 (= A108), T120 (= T109), R144 (= R130), E145 (≠ T131), L262 (≠ N245), D295 (= D278), E311 (= E294), H312 (= H295), V313 (≠ F296), F346 (≠ W324)
- binding nicotinamide-adenine-dinucleotide: G170 (= G154), Y171 (≠ F155), I172 (= I156), P192 (≠ A176), G256 (= G239), V257 (≠ I240), G258 (= G241), E311 (= E294), H312 (= H295), F346 (≠ W324)
Sites not aligning to the query:
Query Sequence
>WP_011778591.1 NCBI__GCF_000015305.1:WP_011778591.1
MSRRTFVTVGAGQTAAVAARNLRRHGFDGRIVLIGDEPHPPYQRPPLSKEFLAGTENEEG
LWILPPKWLQDNDVEIITDTTVVRVDAAARAVEFSGGAGLQADSVLFATGGAPRRLPVDG
PRPDLVHYLRTLDDAARLAPVLTPGRRLAIIGAGFIGLEIAATAAAAGVEVTVLEAVPVP
LARVVGPAMGEAVCRLHRDNGVDIRAGVQLAGVRTAADGVVIDIAGAAAPLEADAVVVGI
GIIPNTAVAAASGLWVDDGIVVDALGRTAVPGVFAAGDAARRYSPRAGRHLRLEHFDNAS
RQGVAVANAMLGREAPSDDPLWFWSDQYGRNIQFVGTASGTPVIRGNRDEFDFTGFYLEN
DTVCGAFAIDRGEDVTAARELLGRGVDAAALLDEDTDLWDLVYADEDEQVRA
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory