SitesBLAST
Comparing WP_011778734.1 NCBI__GCF_000015305.1:WP_011778734.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
3nf4A Crystal structure of acyl-coa dehydrogenase from mycobacterium thermoresistibile bound to flavin adenine dinucleotide (see paper)
80% identity, 99% coverage: 1:377/380 of query aligns to 1:368/369 of 3nf4A
- active site: L127 (= L127), S128 (= S128), G240 (= G242), E354 (= E363), R366 (= R375)
- binding flavin-adenine dinucleotide: Y125 (= Y125), L127 (= L127), S128 (= S128), G133 (= G133), S134 (= S134), W158 (= W158), T160 (= T160), I349 (= I358), T356 (= T365), Q358 (= Q367), I359 (= I368)
4l1fA Electron transferring flavoprotein of acidaminococcus fermentans: towards a mechanism of flavin-based electron bifurcation (see paper)
45% identity, 98% coverage: 9:380/380 of query aligns to 6:380/380 of 4l1fA
- active site: L125 (= L127), T126 (≠ S128), G242 (= G242), E363 (= E363), R375 (= R375)
- binding coenzyme a persulfide: T132 (≠ S134), H179 (≠ Q179), F232 (≠ L232), M236 (≠ F236), E237 (≠ S237), L239 (= L239), D240 (= D240), R243 (= R243), Y362 (≠ F362), E363 (= E363), G364 (= G364), R375 (= R375)
- binding flavin-adenine dinucleotide: F123 (≠ Y125), L125 (= L127), T126 (≠ S128), G131 (= G133), T132 (≠ S134), F156 (≠ W158), I157 (= I159), T158 (= T160), R268 (= R268), Q270 (≠ T270), F271 (= F271), I275 (= I275), F278 (≠ H278), L281 (= L281), Q336 (= Q336), I337 (≠ V337), G340 (= G340), I358 (= I358), Y362 (≠ F362), T365 (= T365), Q367 (= Q367)
- binding 1,3-propandiol: Q10 (≠ R13)
Sites not aligning to the query:
4n5fA Crystal structure of a putative acyl-coa dehydrogenase with bound fadh2 from burkholderia cenocepacia j2315
47% identity, 98% coverage: 7:377/380 of query aligns to 5:378/378 of 4n5fA
- active site: L126 (= L127), T127 (≠ S128), G243 (= G242), E364 (= E363), R376 (= R375)
- binding dihydroflavine-adenine dinucleotide: L126 (= L127), T127 (≠ S128), G132 (= G133), S133 (= S134), F157 (≠ W158), T159 (= T160), T210 (= T209), Y363 (≠ F362), T366 (= T365), E368 (≠ Q367), M372 (≠ L371)
2dvlA Crystal structure of project tt0160 from thermus thermophilus hb8
49% identity, 98% coverage: 9:379/380 of query aligns to 2:370/370 of 2dvlA
- active site: L121 (= L127), T122 (≠ S128), G233 (= G242), E354 (= E363), R366 (= R375)
- binding flavin-adenine dinucleotide: L121 (= L127), T122 (≠ S128), G127 (= G133), S128 (= S134), W152 (= W158), I153 (= I159), T154 (= T160), T356 (= T365), E358 (≠ Q367)
5lnxD Crystal structure of mmgc, an acyl-coa dehydrogenase from bacillus subtilis.
44% identity, 95% coverage: 18:377/380 of query aligns to 12:372/374 of 5lnxD
- active site: L122 (= L127), T123 (≠ S128), G239 (= G242), E358 (= E363), K370 (≠ R375)
- binding flavin-adenine dinucleotide: L122 (= L127), T123 (≠ S128), G128 (= G133), S129 (= S134), F153 (≠ W158), T155 (= T160), R265 (= R268), Q267 (≠ T270), F268 (= F271), I272 (= I275), N275 (≠ H278), I278 (≠ L281), Q331 (= Q336), I332 (≠ V337), G335 (= G340), Y357 (≠ F362), T360 (= T365), E362 (≠ Q367)
4m9aB Crystal structure of acyl-coa dehydrogenase from burkholderia thailandensis e264
45% identity, 98% coverage: 7:377/380 of query aligns to 3:376/376 of 4m9aB
- active site: L124 (= L127), T125 (≠ S128), G241 (= G242), E362 (= E363), R374 (= R375)
- binding dihydroflavine-adenine dinucleotide: F122 (≠ Y125), T125 (≠ S128), G130 (= G133), S131 (= S134), F155 (≠ W158), T157 (= T160), T208 (= T209), Y361 (≠ F362), T364 (= T365), E366 (≠ Q367), M370 (≠ L371)
5ol2F The electron transferring flavoprotein/butyryl-coa dehydrogenase complex from clostridium difficile (see paper)
41% identity, 98% coverage: 7:379/380 of query aligns to 3:378/378 of 5ol2F
- active site: L124 (= L127), T125 (≠ S128), G241 (= G242), G374 (≠ R375)
- binding calcium ion: E29 (≠ Q33), E33 (≠ D37), R35 (≠ T39)
- binding coenzyme a persulfide: L238 (= L239), R242 (= R243), E362 (= E363), G363 (= G364)
- binding flavin-adenine dinucleotide: F122 (≠ Y125), L124 (= L127), T125 (≠ S128), P127 (= P130), T131 (≠ S134), F155 (≠ W158), I156 (= I159), T157 (= T160), E198 (= E199), R267 (= R268), F270 (= F271), L274 (≠ I275), F277 (≠ H278), Q335 (= Q336), L336 (≠ V337), G338 (= G339), G339 (= G340), Y361 (≠ F362), T364 (= T365), E366 (≠ Q367)
3pfdC Crystal structure of an acyl-coa dehydrogenase from mycobacterium thermoresistibile bound to reduced flavin adenine dinucleotide solved by combined iodide ion sad mr (see paper)
44% identity, 95% coverage: 20:379/380 of query aligns to 9:369/369 of 3pfdC
- active site: L116 (= L127), S117 (= S128), T233 (≠ G242), E353 (= E363), R365 (= R375)
- binding dihydroflavine-adenine dinucleotide: Y114 (= Y125), L116 (= L127), S117 (= S128), G122 (= G133), S123 (= S134), W147 (= W158), I148 (= I159), T149 (= T160), R259 (= R268), F262 (= F271), V266 (≠ I275), N269 (≠ H278), Q326 (= Q336), L327 (≠ V337), G330 (= G340), I348 (= I358), Y352 (≠ F362), T355 (= T365), Q357 (= Q367)
1jqiA Crystal structure of rat short chain acyl-coa dehydrogenase complexed with acetoacetyl-coa (see paper)
41% identity, 96% coverage: 15:380/380 of query aligns to 14:382/384 of 1jqiA
- active site: G377 (≠ R375)
- binding acetoacetyl-coenzyme a: L95 (= L95), F125 (≠ Y125), S134 (= S134), F234 (≠ L232), M238 (≠ F236), Q239 (≠ S237), L241 (= L239), D242 (= D240), R245 (= R243), Y364 (≠ F362), E365 (= E363), G366 (= G364)
- binding flavin-adenine dinucleotide: F125 (≠ Y125), L127 (= L127), S128 (= S128), G133 (= G133), S134 (= S134), W158 (= W158), T160 (= T160), R270 (= R268), F273 (= F271), L280 (≠ H278), Q338 (= Q336), I339 (≠ V337), G342 (= G340), I360 (= I358), T367 (= T365), E369 (≠ Q367), I370 (= I368)
P15651 Short-chain specific acyl-CoA dehydrogenase, mitochondrial; SCAD; Butyryl-CoA dehydrogenase; EC 1.3.8.1 from Rattus norvegicus (Rat) (see 2 papers)
41% identity, 96% coverage: 15:380/380 of query aligns to 41:409/412 of P15651
- 152:161 (vs. 125:134, 60% identical) binding FAD
- S161 (= S134) binding substrate
- WIT 185:187 (= WIT 158:160) binding FAD
- DMGR 269:272 (≠ DSGR 240:243) binding substrate
- R297 (= R268) binding FAD
- QILGG 365:369 (≠ QVFGG 336:340) binding FAD
- E392 (= E363) active site, Proton acceptor
- TSE 394:396 (≠ TNQ 365:367) binding FAD
Sites not aligning to the query:
- 1:24 modified: transit peptide, Mitochondrion
8i4rA Crystal structure of acyl-coa dehydrogenase complexed with acetyl-coa from thermobifida fusca
42% identity, 99% coverage: 4:379/380 of query aligns to 2:381/381 of 8i4rA
- binding acetyl coenzyme *a: S132 (= S134), T134 (≠ A136), R180 (≠ Q179), R234 (≠ Q233), L237 (≠ F236), R238 (≠ S237), L240 (= L239), D241 (= D240), R244 (= R243), E365 (= E363), G366 (= G364), R377 (= R375)
- binding flavin-adenine dinucleotide: Y123 (= Y125), L125 (= L127), S126 (= S128), G131 (= G133), S132 (= S134), W156 (= W158), I157 (= I159), T158 (= T160), I360 (= I358), T367 (= T365), Q369 (= Q367)
8i4pA Crystal structure of acyl-coa dehydrogenase from thermobifida fusca
42% identity, 99% coverage: 4:379/380 of query aligns to 2:381/381 of 8i4pA
- binding flavin-adenine dinucleotide: Y123 (= Y125), L125 (= L127), S126 (= S128), G131 (= G133), S132 (= S134), W156 (= W158), I157 (= I159), T158 (= T160), I360 (= I358), Y364 (≠ F362), T367 (= T365), Q369 (= Q367)
7w0jE Acyl-coa dehydrogenase, tfu_1647
42% identity, 99% coverage: 4:379/380 of query aligns to 3:382/382 of 7w0jE
- binding [[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2R,3S,4S)-5-azanyl-2,3,4-tris(oxidanyl)pentyl] hydrogen phosphate: S127 (= S128), W157 (= W158), R270 (= R268), Q272 (≠ T270), F273 (= F271), I277 (= I275), F280 (≠ H278), I283 (≠ L281), Q339 (= Q336), L340 (≠ V337), G343 (= G340), Y365 (≠ F362), E366 (= E363), T368 (= T365), Q370 (= Q367), I371 (= I368)
7y0bA Crystal structure of human short-chain acyl-coa dehydrogenase
41% identity, 96% coverage: 15:380/380 of query aligns to 14:382/385 of 7y0bA
- binding (2S,3R,4R,5S,6R)-2-[4-chloranyl-3-[[4-[(3S)-oxolan-3-yl]oxyphenyl]methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triol: M343 (≠ A341), T347 (≠ R345), E348 (≠ D346)
- binding flavin-adenine dinucleotide: F125 (≠ Y125), L127 (= L127), S128 (= S128), G133 (= G133), S134 (= S134), W158 (= W158), T160 (= T160), R270 (= R268), F273 (= F271), L280 (≠ H278), V282 (≠ G280), Q338 (= Q336), I339 (≠ V337), G342 (= G340), I360 (= I358), Y364 (≠ F362), T367 (= T365), E369 (≠ Q367), I370 (= I368), L373 (= L371)
8sgsA Human liver mitochondrial short-chain specific acyl-coa dehydrogenase (see paper)
41% identity, 96% coverage: 15:380/380 of query aligns to 11:379/381 of 8sgsA
- binding coenzyme a: S131 (= S134), A133 (= A136), N177 (vs. gap), F231 (≠ L232), M235 (≠ F236), L238 (= L239), I312 (≠ S313), E362 (= E363), G363 (= G364)
- binding flavin-adenine dinucleotide: F122 (≠ Y125), L124 (= L127), S125 (= S128), G130 (= G133), S131 (= S134), W155 (= W158), T157 (= T160), R267 (= R268), F270 (= F271), L274 (≠ I275), L277 (≠ H278), Q335 (= Q336), I336 (≠ V337), G338 (= G339), G339 (= G340), I357 (= I358), I360 (= I361), Y361 (≠ F362), T364 (= T365), E366 (≠ Q367)
7y0aC Crystal structure of human short-chain acyl-coa dehydrogenase
41% identity, 96% coverage: 15:380/380 of query aligns to 17:385/387 of 7y0aC
- binding flavin-adenine dinucleotide: F128 (≠ Y125), L130 (= L127), S131 (= S128), G136 (= G133), S137 (= S134), W161 (= W158), T163 (= T160), T214 (= T209), R273 (= R268), F276 (= F271), L280 (≠ I275), L283 (≠ H278), V285 (≠ G280), Q341 (= Q336), I342 (≠ V337), G345 (= G340), I363 (= I358), Y367 (≠ F362), T370 (= T365), E372 (≠ Q367), L376 (= L371)
P16219 Short-chain specific acyl-CoA dehydrogenase, mitochondrial; SCAD; Butyryl-CoA dehydrogenase; EC 1.3.8.1 from Homo sapiens (Human) (see 3 papers)
41% identity, 96% coverage: 15:380/380 of query aligns to 41:409/412 of P16219
- G90 (= G64) to S: in ACADSD; loss of acyl-CoA dehydrogenase activity; dbSNP:rs121908005
- E104 (= E78) natural variant: Missing (in ACADSD; loss of acyl-CoA dehydrogenase activity; dbSNP:rs387906308)
- 152:161 (vs. 125:134, 60% identical) binding in other chain
- R171 (≠ V144) to W: 69% of wild-type acyl-CoA dehydrogenase activity; confers susceptibility to ethylmalonicaciduria; dbSNP:rs1800556
- WIT 185:187 (= WIT 158:160) binding in other chain
- A192 (= A165) to V: in ACADSD; loss of acyl-CoA dehydrogenase activity; dbSNP:rs28940874
- G209 (= G180) to S: 86% of wild-type acyl-CoA dehydrogenase activity; confers susceptibility to ethylmalonicaciduria; dbSNP:rs1799958
- R297 (= R268) binding FAD
- Q308 (= Q279) binding in other chain
- R325 (= R296) to W: in ACADSD; loss of acyl-CoA dehydrogenase activity; dbSNP:rs121908006
- S353 (≠ T324) to L: in ACADSD; loss of acyl-CoA dehydrogenase activity; dbSNP:rs28941773
- QILGG 365:369 (≠ QVFGG 336:340) binding FAD
- R380 (= R351) to W: in ACADSD; loss of acyl-CoA dehydrogenase activity; dbSNP:rs28940875
- TSE 394:396 (≠ TNQ 365:367) binding in other chain
Sites not aligning to the query:
- 1:24 modified: transit peptide, Mitochondrion
1bucA Three-dimensional structure of butyryl-coa dehydrogenase from megasphaera elsdenii (see paper)
40% identity, 98% coverage: 9:379/380 of query aligns to 6:383/383 of 1bucA
- active site: L128 (= L127), T129 (≠ S128), G246 (= G242), E367 (= E363), G379 (≠ R375)
- binding acetoacetyl-coenzyme a: L96 (= L95), F126 (≠ Y125), G134 (= G133), T135 (≠ S134), T162 (= T160), N182 (≠ S178), H183 (≠ Q179), F236 (≠ L232), M240 (≠ F236), M241 (≠ S237), L243 (= L239), D244 (= D240), T317 (≠ S313), Y366 (≠ F362), E367 (= E363), G368 (= G364)
- binding flavin-adenine dinucleotide: F126 (≠ Y125), L128 (= L127), T129 (≠ S128), G134 (= G133), T135 (≠ S134), F160 (≠ W158), T162 (= T160), Y366 (≠ F362), T369 (= T365), E371 (≠ Q367), M375 (≠ L371)
Q06319 Acyl-CoA dehydrogenase, short-chain specific; Butyryl-CoA dehydrogenase; BCAD; SCAD; EC 1.3.8.1 from Megasphaera elsdenii (see paper)
40% identity, 98% coverage: 9:379/380 of query aligns to 6:383/383 of Q06319
- E367 (= E363) active site, Proton acceptor; mutation to Q: Loss of activity.
2vigB Crystal structure of human short-chain acyl coa dehydrogenase
41% identity, 96% coverage: 15:380/380 of query aligns to 8:369/371 of 2vigB
- active site: L121 (= L127), S122 (= S128), G231 (= G242), E352 (= E363), G364 (≠ R375)
- binding coenzyme a persulfide: S128 (= S134), F221 (≠ L232), M225 (≠ F236), Q226 (≠ S237), L228 (= L239), D229 (= D240), R232 (= R243), E352 (= E363), G353 (= G364), I357 (= I368)
- binding flavin-adenine dinucleotide: L121 (= L127), S122 (= S128), G127 (= G133), S128 (= S134), W152 (= W158), T154 (= T160), R257 (= R268), F260 (= F271), L264 (≠ I275), L267 (≠ H278), Q325 (= Q336), I326 (≠ V337), G329 (= G340), I347 (= I358), Y351 (≠ F362), T354 (= T365), E356 (≠ Q367)
Query Sequence
>WP_011778734.1 NCBI__GCF_000015305.1:WP_011778734.1
MAVDRLLPTDEARELVDLARQIADKALDPIVDQHEKDETYPDGVFATLGEAGLLSLPYPE
EWGGGGQPYEVYLQVLEELAARWAAVAVAVSVHSLSCHPLMSFGTDEQRQRWLPEMLGGS
TIGAYSLSEPQAGSDAAALTCKAVAADGGYRINGAKAWITHGGIADFYNLFARTGEGSQG
ISCFLVPRDTEGLTFGKPEEKMGLHAVPTTAAHYENAFVEADRRIGAEGQGLQIAFSALD
SGRLGIAAVAVGLAQAALDAAVDYSQERTTFGRKIIDHQGLAFLLADMAAAVDAARATYL
DAARRRDAGLPYSRHASVAKLTATDAAMKVTTDAVQVFGGAGYTRDYRVERYMREAKITQ
IFEGTNQIQRLVISRHLARD
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory