SitesBLAST
Comparing WP_011779164.1 NCBI__GCF_000015305.1:WP_011779164.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 4 hits to proteins with known functional sites (download)
H1ZZB0 Aurachin B dehydrogenase; EC 1.1.1.394 from Stigmatella aurantiaca (see paper)
30% identity, 71% coverage: 1:211/297 of query aligns to 1:221/334 of H1ZZB0
- S111 (= S109) mutation to A: Does not produce aurachin B.
- Y139 (≠ E135) mutation to F: Does not produce aurachin B.
3aw9A Structure of udp-galactose 4-epimerase mutant
27% identity, 94% coverage: 1:278/297 of query aligns to 1:286/304 of 3aw9A
- active site: A105 (= A108), S107 (≠ G110), S108 (≠ M111), T109 (≠ A112), Y131 (vs. gap), K135 (≠ R132), L166 (≠ G161), G169 (= G164)
- binding galactose-uridine-5'-diphosphate: P69 (≠ H75), V71 (≠ F77), S107 (≠ G110), Y131 (vs. gap), N160 (≠ P155), H168 (= H163), V170 (≠ F165), D173 (≠ T168), L188 (≠ P182), Q193 (≠ N187), K195 (≠ W189), Y197 (≠ A191), V234 (= V224), W263 (≠ F253), D266 (≠ A256)
- binding nicotinamide-adenine-dinucleotide: G7 (= G7), G10 (= G10), F11 (= F11), I12 (= I12), D31 (≠ A35), I32 (≠ A36), R46 (≠ G50), D47 (= D51), L48 (= L52), F65 (≠ L71), A66 (= A72), A67 (≠ F73), E82 (≠ R88), A105 (= A108), S106 (= S109), Y131 (vs. gap), K135 (≠ R132), Y158 (≠ L153), N160 (≠ P155), V161 (≠ T156), H168 (= H163)
6kvcA Moee5 in complex with udp-glucose and NAD (see paper)
31% identity, 62% coverage: 3:187/297 of query aligns to 3:196/299 of 6kvcA
- active site: S109 (= S109), S110 (≠ G110), S111 (≠ M111), Y132 (≠ R132), K136 (vs. gap)
- binding nicotinamide-adenine-dinucleotide: G7 (= G7), G10 (= G10), F11 (= F11), I12 (= I12), D31 (≠ A31), R32 (= R32), R33 (= R39), D46 (= D51), L47 (= L52), L65 (= L71), A66 (= A72), A67 (vs. gap), P69 (vs. gap), A107 (≠ V107), S109 (= S109), K136 (vs. gap), F161 (≠ L153), T163 (= T156), V164 (= V157), R170 (≠ H163), M173 (≠ G164)
- binding uridine-5'-diphosphate-glucose: P69 (vs. gap), R72 (≠ Q74), S109 (= S109), S110 (≠ G110), Y132 (≠ R132), T163 (= T156), M173 (≠ G164), F174 (= F165), R177 (≠ T168), E189 (≠ S179), I190 (≠ T180), Y191 (= Y181), Q196 (≠ N187)
Sites not aligning to the query:
6kv9A Moee5 in complex with udp-glucuronic acid and NAD (see paper)
31% identity, 62% coverage: 3:187/297 of query aligns to 3:197/299 of 6kv9A
- active site: S110 (= S109), S111 (≠ G110), S112 (≠ M111), Y133 (≠ R132), K137 (vs. gap)
- binding nicotinamide-adenine-dinucleotide: G7 (= G7), G10 (= G10), F11 (= F11), I12 (= I12), D31 (≠ A31), R32 (= R32), R33 (≠ Q38), D47 (= D51), L48 (= L52), L66 (= L71), A67 (= A72), A68 (vs. gap), P70 (vs. gap), C85 (≠ V86), A108 (≠ V107), S109 (≠ A108), K137 (vs. gap), F162 (≠ L153), T164 (= T156), V165 (= V157), R171 (≠ H163), M174 (≠ G164)
- binding uridine-5'-diphosphate-glucuronic acid: P70 (vs. gap), R73 (≠ Q74), S110 (= S109), S111 (≠ G110), Y133 (≠ R132), T164 (= T156), R171 (≠ H163), M174 (≠ G164), F175 (= F165), R178 (≠ T168), E190 (≠ S179), I191 (≠ T180), Y192 (= Y181), Q197 (≠ N187)
Sites not aligning to the query:
Query Sequence
>WP_011779164.1 NCBI__GCF_000015305.1:WP_011779164.1
MKVFVTGASGFIGSAVTAELLGHGHHVLGLARSDAAAQRITATGAEAVRGDLDDLDALEA
GASAADAVIHLAFQHDFTAYDTAARVDRQAIETLGEALAGSDRALVVASGMAGLGRGRIL
TEDQAAPPDAPRESEPAVFAFTDRGVRAAAVRLAPTVHGEGDHGFVPTLISIARATGVST
YPGDGSNRWPAVHRLDAAALFRIAAEDAPAGTLLHAVADEGIPVRQIAEAIGHGLDVSVE
ATTAQASIDRAGFIGAVFAMDLPASSALTRTQFGWQPTHPGLLADLSQAHYFATPEA
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory