SitesBLAST
Comparing WP_011781617.1 NCBI__GCF_000015305.1:WP_011781617.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
7qh2C Cryo-em structure of ldh-etfab complex from acetobacterium woodii (see paper)
37% identity, 91% coverage: 39:449/453 of query aligns to 45:460/467 of 7qh2C
- binding flavin-adenine dinucleotide: V73 (≠ P67), G75 (= G69), S76 (≠ M70), G77 (= G71), T78 (= T72), G79 (= G73), L80 (= L74), A83 (≠ G77), C84 (≠ A78), P137 (= P130), G138 (≠ S131), E139 (≠ S132), A142 (≠ C136), T143 (≠ S137), G146 (= G140), N147 (= N141), S149 (≠ A143), T150 (= T144), A152 (= A146), G153 (= G147), E203 (= E197), G204 (= G198), I209 (≠ V203), E422 (= E411), H423 (= H412)
- binding fe (iii) ion: H377 (= H367), H384 (= H374), E422 (= E411)
P9WIT1 Uncharacterized FAD-linked oxidoreductase Rv2280; EC 1.-.-.- from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
34% identity, 97% coverage: 13:450/453 of query aligns to 14:453/459 of P9WIT1
- K354 (≠ E346) modified: Isoglutamyl lysine isopeptide (Lys-Gln) (interchain with Q-Cter in protein Pup)
8jdeA Crystal structure of mldhd in complex with d-lactate (see paper)
31% identity, 97% coverage: 16:453/453 of query aligns to 12:455/455 of 8jdeA
- binding flavin-adenine dinucleotide: P68 (= P67), G70 (= G69), T71 (≠ M70), G72 (= G71), T73 (= T72), G74 (= G73), G78 (= G77), V79 (≠ A78), L90 (≠ T89), P132 (= P130), G133 (≠ S131), A134 (≠ S132), G140 (= G140), M141 (≠ N141), A143 (= A143), T144 (= T144), A146 (= A146), S147 (≠ G147), E200 (= E197), G201 (= G198), I206 (≠ V203), W322 (≠ R320), E413 (= E411), H414 (= H412), N450 (= N448)
- binding lactic acid: R318 (≠ V316), H369 (= H367), H376 (= H374), H414 (= H412)
- binding manganese (ii) ion: H369 (= H367), H376 (= H374), E413 (= E411)
8jdvA Crystal structure of mldhd in complex with 2-ketohexanoic acid (see paper)
32% identity, 97% coverage: 16:453/453 of query aligns to 12:454/454 of 8jdvA
- binding 2-Ketohexanoic acid: V75 (≠ L74), R317 (≠ V316), W321 (≠ R320), H368 (= H367), H375 (= H374), H413 (= H412)
- binding flavin-adenine dinucleotide: P68 (= P67), G70 (= G69), T71 (≠ M70), G72 (= G71), T73 (= T72), G74 (= G73), G78 (= G77), V79 (≠ A78), L90 (≠ T89), P132 (= P130), G133 (≠ S131), A134 (≠ S132), G140 (= G140), M141 (≠ N141), A143 (= A143), T144 (= T144), A146 (= A146), S147 (≠ G147), E200 (= E197), G201 (= G198), I206 (≠ V203), W321 (≠ R320), Y322 (≠ F321), E412 (= E411), H413 (= H412), N449 (= N448)
- binding manganese (ii) ion: H368 (= H367), H375 (= H374), E412 (= E411)
8jdsA Crystal structure of mldhd in complex with pyruvate (see paper)
32% identity, 97% coverage: 16:453/453 of query aligns to 12:456/456 of 8jdsA
- binding flavin-adenine dinucleotide: E32 (≠ P34), P68 (= P67), G70 (= G69), T71 (≠ M70), G72 (= G71), T73 (= T72), G74 (= G73), G78 (= G77), V79 (≠ A78), L90 (≠ T89), P132 (= P130), G133 (≠ S131), A134 (≠ S132), G140 (= G140), M141 (≠ N141), A143 (= A143), T144 (= T144), A146 (= A146), S147 (≠ G147), E200 (= E197), G201 (= G198), I206 (≠ V203), W323 (vs. gap), E414 (= E411), H415 (= H412), N451 (= N448)
- binding manganese (ii) ion: H370 (= H367), H377 (= H374), E414 (= E411)
- binding pyruvic acid: R319 (≠ A318), H370 (= H367), H377 (= H374), H415 (= H412)
8jdxA Crystal structure of mldhd in complex with 2-ketoisovaleric acid (see paper)
31% identity, 97% coverage: 16:453/453 of query aligns to 12:455/455 of 8jdxA
- binding flavin-adenine dinucleotide: E32 (≠ P34), P68 (= P67), G70 (= G69), T71 (≠ M70), G72 (= G71), T73 (= T72), G74 (= G73), G78 (= G77), V79 (≠ A78), L90 (≠ T89), P132 (= P130), G133 (≠ S131), A134 (≠ S132), G140 (= G140), M141 (≠ N141), A143 (= A143), T144 (= T144), A146 (= A146), S147 (≠ G147), E200 (= E197), G201 (= G198), I206 (≠ V203), W322 (vs. gap), E413 (= E411), H414 (= H412), N450 (= N448)
- binding 3-methyl-2-oxobutanoic acid: R318 (≠ A318), H369 (= H367), H376 (= H374), H414 (= H412)
- binding manganese (ii) ion: H369 (= H367), H376 (= H374), E413 (= E411)
8jduA Crystal structure of mldhd in complex with 2-ketovaleric acid (see paper)
31% identity, 97% coverage: 16:453/453 of query aligns to 12:455/455 of 8jduA
- binding 2-oxopentanoic acid: R318 (≠ V316), W322 (≠ R320), H369 (= H367), H376 (= H374), H414 (= H412)
- binding flavin-adenine dinucleotide: P68 (= P67), G70 (= G69), T71 (≠ M70), G72 (= G71), T73 (= T72), G74 (= G73), G78 (= G77), V79 (≠ A78), L90 (≠ T89), P132 (= P130), G133 (≠ S131), A134 (≠ S132), G140 (= G140), M141 (≠ N141), A143 (= A143), T144 (= T144), A146 (= A146), S147 (≠ G147), E200 (= E197), G201 (= G198), I206 (≠ V203), W322 (≠ R320), E413 (= E411), N450 (= N448)
- binding manganese (ii) ion: H369 (= H367), H376 (= H374), E413 (= E411)
8jdtA Crystal structure of mldhd in complex with 2-ketobutanoic acid (see paper)
31% identity, 97% coverage: 16:453/453 of query aligns to 12:455/455 of 8jdtA
- binding 2-ketobutyric acid: R318 (≠ V316), H369 (= H367), H376 (= H374), H414 (= H412)
- binding flavin-adenine dinucleotide: P68 (= P67), G70 (= G69), T71 (≠ M70), G72 (= G71), T73 (= T72), G74 (= G73), G78 (= G77), V79 (≠ A78), L90 (≠ T89), P132 (= P130), G133 (≠ S131), A134 (≠ S132), G140 (= G140), M141 (≠ N141), A143 (= A143), T144 (= T144), A146 (= A146), S147 (≠ G147), E200 (= E197), G201 (= G198), I206 (≠ V203), W322 (≠ R320), E413 (= E411), H414 (= H412), N450 (= N448)
- binding manganese (ii) ion: H369 (= H367), H376 (= H374), E413 (= E411)
6lpxA Crystal structure of human d-2-hydroxyglutarate dehydrogenase in complex with 2-oxoglutarate (2-og) (see paper)
32% identity, 99% coverage: 2:449/453 of query aligns to 12:460/466 of 6lpxA
- binding 2-oxoglutaric acid: R333 (= R319), T337 (≠ I323), K348 (≠ L334), Y379 (≠ I365), H381 (= H367), H388 (= H374), H423 (= H412)
- binding flavin-adenine dinucleotide: W39 (≠ R30), P75 (= P67), Q76 (≠ R68), G77 (= G69), G78 (≠ M70), N79 (≠ G71), T80 (= T72), G81 (= G73), M82 (≠ L74), G85 (= G77), S86 (≠ A78), L139 (≠ P130), G140 (≠ S131), A141 (≠ S132), C145 (= C136), G149 (= G140), N150 (= N141), A152 (= A143), T153 (= T144), G157 (= G148), G207 (= G198), I212 (≠ V203), E422 (= E411), N459 (= N448)
- binding zinc ion: H381 (= H367), H388 (= H374), E422 (= E411)
6lpuA Crystal structure of human d-2-hydroxyglutarate dehydrogenase in complex with l-2-hydroxyglutarate (l-2-hg) (see paper)
32% identity, 99% coverage: 2:449/453 of query aligns to 12:460/466 of 6lpuA
- binding flavin-adenine dinucleotide: W39 (≠ R30), P75 (= P67), G77 (= G69), G78 (≠ M70), N79 (≠ G71), T80 (= T72), G81 (= G73), G85 (= G77), S86 (≠ A78), L139 (≠ P130), G140 (≠ S131), A141 (≠ S132), C145 (= C136), H146 (≠ S137), G148 (= G139), G149 (= G140), N150 (= N141), A152 (= A143), T153 (= T144), A155 (= A146), E206 (= E197), G207 (= G198), I211 (≠ V202), I212 (≠ V203), E422 (= E411), N459 (= N448)
- binding (2s)-2-hydroxypentanedioic acid: R333 (= R319), T337 (≠ I323), K348 (≠ L334), Y379 (≠ I365), H381 (= H367), H388 (= H374), H423 (= H412)
- binding zinc ion: H381 (= H367), H388 (= H374), E422 (= E411)
6lpqA Crystal structure of human d-2-hydroxyglutarate dehydrogenase in complex with d-malate (d-mal) (see paper)
32% identity, 99% coverage: 2:449/453 of query aligns to 12:460/466 of 6lpqA
- binding flavin-adenine dinucleotide: W39 (≠ R30), P75 (= P67), G77 (= G69), G78 (≠ M70), N79 (≠ G71), T80 (= T72), G81 (= G73), G85 (= G77), S86 (≠ A78), L139 (≠ P130), G140 (≠ S131), A141 (≠ S132), C145 (= C136), H146 (≠ S137), G149 (= G140), N150 (= N141), A152 (= A143), T153 (= T144), A155 (= A146), G157 (= G148), E206 (= E197), G207 (= G198), I211 (≠ V202), I212 (≠ V203), E422 (= E411), N459 (= N448)
- binding d-malate: M82 (≠ L74), R333 (= R319), T337 (≠ I323), K348 (≠ L334), Y379 (≠ I365), H381 (= H367), H388 (= H374), E422 (= E411), H423 (= H412)
- binding zinc ion: H381 (= H367), H388 (= H374), E422 (= E411)
6lppA Crystal structure of human d-2-hydroxyglutarate dehydrogenase in complex with d-2-hydroxyglutarate (d-2-hg) (see paper)
32% identity, 99% coverage: 2:449/453 of query aligns to 12:460/466 of 6lppA
- binding (2R)-2-hydroxypentanedioic acid: R333 (= R319), T337 (≠ I323), K348 (≠ L334), Y379 (≠ I365), H381 (= H367), H388 (= H374), N390 (≠ L376), H423 (= H412)
- binding flavin-adenine dinucleotide: W39 (≠ R30), P75 (= P67), G77 (= G69), G78 (≠ M70), N79 (≠ G71), T80 (= T72), G81 (= G73), M82 (≠ L74), G85 (= G77), S86 (≠ A78), L139 (≠ P130), G140 (≠ S131), A141 (≠ S132), C145 (= C136), G149 (= G140), N150 (= N141), A152 (= A143), T153 (= T144), A155 (= A146), G157 (= G148), G207 (= G198), I212 (≠ V203), E422 (= E411), H423 (= H412)
- binding zinc ion: H381 (= H367), H388 (= H374), E422 (= E411)
6lpnB Crystal structure of human d-2-hydroxyglutarate dehydrogenase in apo form (see paper)
32% identity, 99% coverage: 2:449/453 of query aligns to 13:461/467 of 6lpnB
- binding flavin-adenine dinucleotide: W40 (≠ R30), P76 (= P67), G78 (= G69), G79 (≠ M70), N80 (≠ G71), T81 (= T72), G82 (= G73), M83 (≠ L74), G86 (= G77), S87 (≠ A78), L140 (≠ P130), A142 (≠ S132), C146 (= C136), H147 (≠ S137), G150 (= G140), N151 (= N141), A153 (= A143), T154 (= T144), G208 (= G198), I212 (≠ V202), I213 (≠ V203), E423 (= E411), N460 (= N448)
Q8N465 D-2-hydroxyglutarate dehydrogenase, mitochondrial; EC 1.1.99.39 from Homo sapiens (Human) (see 7 papers)
32% identity, 99% coverage: 2:449/453 of query aligns to 65:513/521 of Q8N465
- S109 (≠ T48) to W: in D2HGA1; uncertain significance; significant loss of catalytic activity; dbSNP:rs142050154
- N127 (≠ V66) to K: in D2HGA1; uncertain significance; complete loss of catalytic activity; dbSNP:rs762857195
- G131 (≠ M70) to V: in D2HGA1; uncertain significance; complete loss of catalytic activity
- I147 (≠ V86) to S: in D2HGA1; uncertain significance; severe phenotype; almost complete loss of catalytic activity; dbSNP:rs121434361
- M153 (= M92) to T: in D2HGA1; uncertain significance; significant loss of catalytic activity; to V: in D2HGA1; uncertain significance; significant loss of catalytic activity; dbSNP:rs1432270139
- C172 (≠ L110) to Y: in D2HGA1; uncertain significance; moderate reduction in catalytic activity; dbSNP:rs773735172
- P189 (= P127) to L: in D2HGA1; uncertain significance; almost complete loss of catalytic activity; dbSNP:rs587783517
- A205 (= A143) to V: in D2HGA1; uncertain significance; almost complete loss of catalytic activity; dbSNP:rs750889931
- A231 (= A169) to V: in D2HGA1; uncertain significance; significant loss of catalytic activity
- G233 (= G171) to S: in D2HGA1; uncertain significance; no effect on catalytic activity; dbSNP:rs374535734
- D375 (= D308) to Y: in D2HGA1; uncertain significance; moderate reduction in catalytic activity; dbSNP:rs267606759
- R386 (= R319) binding (R)-2-hydroxyglutarate; binding (R)-lactate; binding (R)-malate; mutation to A: Loss of catalytic activity.
- T390 (≠ I323) binding (R)-2-hydroxyglutarate; binding (R)-malate; mutation to A: Significantly reduced catalytic activity.
- V399 (≠ L332) to M: in D2HGA1; uncertain significance; moderate reduction in catalytic activity; dbSNP:rs746519212
- K401 (≠ L334) binding (R)-2-hydroxyglutarate; binding (R)-malate; mutation to A: Loss of catalytic activity.
- R419 (≠ E352) to H: in D2HGA1; uncertain significance; moderate reduction in catalytic activity; dbSNP:rs199908032
- A426 (≠ E359) to T: in D2HGA1; uncertain significance; no effect on catalytic activity; dbSNP:rs146578303
- H434 (= H367) binding Zn(2+); mutation to A: Loss of catalytic activity.
- G436 (= G369) to V: slight reduction in catalytic activity
- N439 (= N372) to D: in D2HGA1; uncertain significance; mild phenotype; moderate reduction in catalytic activity; dbSNP:rs121434362
- H441 (= H374) binding Zn(2+); mutation to A: Loss of catalytic activity.
- N443 (≠ L376) binding (R)-2-hydroxyglutarate; mutation to A: Significantly reduced catalytic activity.
- V444 (≠ I377) to A: in D2HGA1; uncertain significance; severe phenotype; significant reduction in catalytic activity; dbSNP:rs121434360
- A446 (≠ F379) to V: in D2HGA1; uncertain significance; moderate reduction in catalytic activity; dbSNP:rs746956176
- E475 (= E411) binding Zn(2+); mutation to A: Loss of catalytic activity.
- H476 (= H412) binding (R)-2-hydroxyglutarate; binding (R)-lactate; binding (R)-malate; mutation to A: Loss of catalytic activity.
- G477 (= G413) to R: in D2HGA1; uncertain significance; almost complete loss of catalytic activity; dbSNP:rs1453924640
Sites not aligning to the query:
- 15 R → G: in dbSNP:rs4675887
- 169:521 natural variant: Missing (in D2HGA1; uncertain significance)
- 400:521 natural variant: Missing (in D2HGA1; uncertain significance; complete loss of catalytic activity)
8jdrA Crystal structure of h405a mldhd in complex with d-2-hydroxy-3-methyl- valeric acid (see paper)
31% identity, 97% coverage: 16:453/453 of query aligns to 12:456/456 of 8jdrA
- binding flavin-adenine dinucleotide: P68 (= P67), G70 (= G69), T71 (≠ M70), G72 (= G71), T73 (= T72), G74 (= G73), G78 (= G77), V79 (≠ A78), L90 (≠ T89), P132 (= P130), G133 (≠ S131), A134 (≠ S132), G140 (= G140), M141 (≠ N141), A143 (= A143), T144 (= T144), A146 (= A146), S147 (≠ G147), E200 (= E197), G201 (= G198), I206 (≠ V203), Y324 (≠ F321), H370 (= H367), E414 (= E411), N451 (= N448)
- binding (2R,3S)-3-methyl-2-oxidanyl-pentanoic acid: R319 (≠ A318), W323 (vs. gap), H415 (= H412)
8jdqA Crystal structure of h405a mldhd in complex with d-2-hydroxyisocaproic acid (see paper)
31% identity, 97% coverage: 16:453/453 of query aligns to 12:456/456 of 8jdqA
- binding (2R)-2-hydroxy-4-methylpentanoic acid: R319 (≠ A318), W323 (vs. gap), H370 (= H367), H415 (= H412)
- binding flavin-adenine dinucleotide: P68 (= P67), G70 (= G69), T71 (≠ M70), G72 (= G71), T73 (= T72), G74 (= G73), G78 (= G77), V79 (≠ A78), L90 (≠ T89), P132 (= P130), G133 (≠ S131), A134 (≠ S132), G140 (= G140), M141 (≠ N141), A143 (= A143), T144 (= T144), A146 (= A146), S147 (≠ G147), E200 (= E197), G201 (= G198), I206 (≠ V203), H370 (= H367), E414 (= E411), N451 (= N448)
8jdoA Crystal structure of h405a mldhd in complex with d-2-hydroxyhexanoic acid (see paper)
31% identity, 97% coverage: 16:453/453 of query aligns to 12:456/456 of 8jdoA
- binding (2R)-2-hydroxyhexanoic acid: R319 (≠ A318), W323 (vs. gap), H415 (= H412)
- binding flavin-adenine dinucleotide: P68 (= P67), G70 (= G69), T71 (≠ M70), G72 (= G71), T73 (= T72), G74 (= G73), G78 (= G77), V79 (≠ A78), L90 (≠ T89), P132 (= P130), G133 (≠ S131), A134 (≠ S132), G140 (= G140), M141 (≠ N141), A143 (= A143), T144 (= T144), A146 (= A146), S147 (≠ G147), E200 (= E197), G201 (= G198), I206 (≠ V203), Y324 (≠ F321), H370 (= H367), E414 (= E411), N451 (= N448)
8jdnA Crystal structure of h405a mldhd in complex with d-2-hydroxyvaleric acid (see paper)
31% identity, 97% coverage: 16:453/453 of query aligns to 12:456/456 of 8jdnA
- binding flavin-adenine dinucleotide: P68 (= P67), G70 (= G69), T71 (≠ M70), G72 (= G71), T73 (= T72), G74 (= G73), G78 (= G77), V79 (≠ A78), L90 (≠ T89), P132 (= P130), G133 (≠ S131), A134 (≠ S132), G140 (= G140), M141 (≠ N141), A143 (= A143), T144 (= T144), A146 (= A146), S147 (≠ G147), E200 (= E197), G201 (= G198), I206 (≠ V203), H370 (= H367), E414 (= E411), N451 (= N448)
- binding (2R)-2-oxidanylpentanoic acid: R319 (≠ A318), W323 (vs. gap), H415 (= H412)
8jdgA Crystal structure of h405a mldhd in complex with d-2-hydroxybutanoic acid (see paper)
31% identity, 97% coverage: 16:453/453 of query aligns to 12:456/456 of 8jdgA
- binding flavin-adenine dinucleotide: P68 (= P67), G70 (= G69), T71 (≠ M70), G72 (= G71), T73 (= T72), G74 (= G73), G78 (= G77), V79 (≠ A78), L90 (≠ T89), P132 (= P130), G133 (≠ S131), A134 (≠ S132), G140 (= G140), M141 (≠ N141), A143 (= A143), T144 (= T144), A146 (= A146), S147 (≠ G147), E200 (= E197), G201 (= G198), I206 (≠ V203), H370 (= H367), E414 (= E411), N451 (= N448)
- binding (2R)-2-oxidanylbutanoic acid: R319 (≠ A318), H415 (= H412)
8jdbA Crystal structure of h405a mldhd in complex with d-2-hydroxyoctanoic acid (see paper)
31% identity, 97% coverage: 16:453/453 of query aligns to 12:456/456 of 8jdbA
- binding flavin-adenine dinucleotide: P68 (= P67), G70 (= G69), T71 (≠ M70), G72 (= G71), T73 (= T72), G74 (= G73), G78 (= G77), V79 (≠ A78), L90 (≠ T89), P132 (= P130), G133 (≠ S131), A134 (≠ S132), G140 (= G140), M141 (≠ N141), A143 (= A143), T144 (= T144), A146 (= A146), S147 (≠ G147), E200 (= E197), G201 (= G198), I206 (≠ V203), Y324 (≠ F321), H370 (= H367), E414 (= E411), N451 (= N448)
- binding (2R)-2-oxidanyloctanoic acid: V75 (≠ L74), R319 (≠ A318), W323 (vs. gap), H415 (= H412)
Query Sequence
>WP_011781617.1 NCBI__GCF_000015305.1:WP_011781617.1
MQPLASLIAELPDGTVVTDPDIVASYRQDRAADPSAGTPIAVVRPRRTEEVQATLRWATA
HRIAVVPRGMGTGLSGGATALDGGIVLSTEKMRDITVDPVTRTAVAQPGLLNAEVKKAVA
EYGLWYPPDPSSFEICSIGGNIATNAGGLCCVKYGVTTDYVLGLQVVLADGTAVRLGGPR
LKDVAGLSLTKLFVGSEGTLGVVTEVTLKLLPAQSGACTVVATFDSVEDAANAVVTITGK
IRPSMLEFMDSAAINAVEDKLKMGLDRSAAAMMVAASDDRGPSGAQDAEFMAGVFTEHGA
REVFSTSDPDEGEAFVAARRFAIPAVEARGALLLEDVGVPLPALAELVGGVEKIAGHHEL
MISVIAHAGDGNTHPLIVFDPDDPDMERRAQQAFGEIMDLAIGLGGTITGEHGVGRLKRP
WLAGQLGPEAMELNRRIKQALDPDGILNPGAAI
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory