SitesBLAST

101 Important for activation via AroG; G→A: The catalytic efficiency and the affinity are 5 and 3-fold lower than the wild-type. The activation by AroG is 10-fold lower than the wild-type.
102 Important for activation via AroG; R→A: The catalytic efficiency and the affinity are slightly modified. The activation by AroG is 2-fold lower than the wild-type.
103 Important for activation via AroG; L→A: The catalytic efficiency and the affinity are identical to the wild-type. The activation by AroG is 10-fold lower than the wild type.

5ckxD Non-covalent complex of dahp synthase and chorismate mutase from mycobacterium tuberculosis with bound transition state analog and feedback effectors tyrosine and phenylalanine (see paper)
78% identity, 71% coverage: 16:82/94 of query aligns to 1:67/79 of 5ckxD

query
sites
5ckxD

N

P

D

E

I

I

D

D

E

T

L

L

R

R

E

E

I

I

D

D

R

R

L

L

D

D

A

A

A

E

I

I

L

L

E

A

A

L

V

V

Q

K

R

R

R
|
R

T

A

E

E

V

V

S
|
S

Q

K

L

A

I
|
I

G

G

K

K

A

A

R
|
R

M

M

A

A

S

S

G

G

T

T

R

R

L

L

V

V

H

H

S

S

R
|
R

E
|
E

M

M

K

K

V

V

I

I

E

E

R

R

Y

Y

S

S

V

E

L

L

G

G

D

P

E

D

G

G

K

K

N

D

L

L

A

A

M

I

binding 8-hydroxy-2-oxa-bicyclo[3.3.1]non-6-ene-3,5-dicarboxylic acid: R24 (= R39), S28 (= S43), I31 (= I46), R35 (= R50), R47 (= R62), E48 (= E63)

Sites not aligning to the query:

binding 8-hydroxy-2-oxa-bicyclo[3.3.1]non-6-ene-3,5-dicarboxylic acid: 70

5hudE Non-covalent complex of and dahp synthase and chorismate mutase from corynebacterium glutamicum with bound transition state analog (see paper)
59% identity, 82% coverage: 17:93/94 of query aligns to 7:84/84 of 5hudE

query
sites
5hudE

D

E

I

I

D

Q

E

K

L

Y

R

R

E

E

I

I

D

N

R

R

L

L

D

D

A

R

A

E

I

I

L

L

E

D

A

A

V

V

Q

K

R

R

R
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R

T

T

E

K

V

I

S
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S

Q

Q

L

T

I
|
I

G

G

K

K

A

T

R
|
R

M

M

A

S

S

S

G

G

T

T

R

R

L
|
L

V
|
V

H

H

S

T

R
|
R

E
|
E

M

V

K

A

V

I

I

I

E

N

R

Q

Y

F

-

R

S

E

V

E

L

I

G

G

D

E

E

E

G

G

K

P

N

A

L

L

A

A

M

G

L

I

L

L

L
|
L

R

R

L

M

G

G

R

R

G

G

R

K

L

L

G

G

binding 8-hydroxy-2-oxa-bicyclo[3.3.1]non-6-ene-3,5-dicarboxylic acid: R29 (= R39), S33 (= S43), I36 (= I46), R40 (= R50), L48 (= L58), V49 (= V59), R52 (= R62), E53 (= E63), L76 (= L85)

Query Sequence

>WP_011782020.1 NCBI__GCF_000015305.1:WP_011782020.1
MTTMETTGSSGSSEANDIDELREEIDRLDAAILEAVQRRTEVSQLIGKARMASGGTRLVH
SREMKVIERYSVLGDEGKNLAMLLLRLGRGRLGK

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory