SitesBLAST
Comparing WP_011782575.1 NCBI__GCF_000015305.1:WP_011782575.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
1h2bB Crystal structure of the alcohol dehydrogenase from the hyperthermophilic archaeon aeropyrum pernix at 1.65a resolution (see paper)
37% identity, 99% coverage: 3:354/356 of query aligns to 1:343/344 of 1h2bB
- active site: C39 (= C40), H40 (≠ R41), T41 (= T42), H44 (≠ Q45), H64 (= H65), E65 (= E66), D94 (= D98), C97 (= C101), C100 (= C104), C108 (= C112), E112 (≠ V116), D153 (= D156), T157 (= T160), R339 (= R350)
- binding nicotinamide-adenine-dinucleotide (acidic form): C39 (= C40), H40 (≠ R41), T41 (= T42), H44 (≠ Q45), T157 (= T160), V180 (≠ I185), G181 (= G186), G182 (= G187), L183 (= L188), D203 (≠ A209), V204 (≠ R210), K208 (= K214), F246 (≠ C256), V247 (≠ A257), T252 (≠ S262), Y255 (≠ L265), V269 (= V279), G270 (= G280), Y271 (≠ L281), L293 (≠ F304), V294 (≠ W305), R339 (= R350)
- binding octanoic acid (caprylic acid): T41 (= T42), W50 (≠ F51), H64 (= H65), D153 (= D156), V294 (≠ W305)
- binding zinc ion: C39 (= C40), H64 (= H65), D94 (= D98), C97 (= C101), C100 (= C104), C108 (= C112), D153 (= D156)
Q97YM2 D-arabinose 1-dehydrogenase (NADP(+)); AraDH; D-Ara dehydrogenase; EC 1.1.1.427 from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus) (see paper)
35% identity, 99% coverage: 1:353/356 of query aligns to 7:347/349 of Q97YM2
- C46 (= C40) binding Zn(2+)
- H70 (= H65) binding Zn(2+)
- D99 (= D98) binding Zn(2+)
- C102 (= C101) binding Zn(2+)
- C105 (= C104) binding Zn(2+)
- C113 (= C112) binding Zn(2+)
- D155 (= D156) binding Zn(2+)
2eerB Structural study of project id st2577 from sulfolobus tokodaii strain7
35% identity, 99% coverage: 3:354/356 of query aligns to 1:346/347 of 2eerB
- active site: C38 (= C40), H39 (≠ R41), S40 (≠ T42), H43 (≠ Q45), H68 (= H65), E69 (= E66), E98 (≠ D98), C101 (= C101), C104 (= C104), C112 (= C112), R116 (≠ V116), C154 (≠ D156), T158 (= T160), R342 (= R350)
- binding nicotinamide-adenine-dinucleotide: C38 (= C40), H39 (≠ R41), S40 (≠ T42), H43 (≠ Q45), C154 (≠ D156), T158 (= T160), G178 (= G184), G181 (= G187), G182 (vs. gap), L183 (= L188), D203 (≠ A209), V204 (≠ R210), R205 (≠ S211), L247 (≠ C256), N248 (≠ A257), V270 (= V279), G271 (= G280), L272 (= L281), F273 (≠ I282), L295 (≠ F304), V296 (≠ W305), R342 (= R350)
- binding zinc ion: E98 (≠ D98), C101 (= C101), C104 (= C104), C112 (= C112)
1lluA The ternary complex of pseudomonas aeruginosa alcohol dehydrogenase with its coenzyme and weak substrate (see paper)
35% identity, 99% coverage: 3:353/356 of query aligns to 6:339/341 of 1lluA
- active site: C43 (= C40), H44 (≠ R41), T45 (= T42), H48 (≠ Q45), H66 (= H65), E67 (= E66), C97 (≠ D98), C100 (= C101), C103 (= C104), C111 (= C112), Q115 (≠ V116), C153 (≠ D156), T157 (= T160), R336 (= R350)
- binding 1,2-ethanediol: H44 (≠ R41), T45 (= T42), L47 (≠ F44), D53 (= D52), W92 (= W96), C153 (≠ D156)
- binding nicotinamide-adenine-dinucleotide: C43 (= C40), H44 (≠ R41), T45 (= T42), H48 (≠ Q45), C153 (≠ D156), T157 (= T160), G179 (= G186), G180 (= G187), L181 (= L188), D200 (≠ A209), I201 (≠ R210), K205 (= K214), A243 (= A257), V244 (≠ G258), S245 (= S259), A248 (≠ S262), V265 (= V279), L267 (= L281), I290 (≠ F304), V291 (≠ W305), R336 (= R350)
- binding zinc ion: C43 (= C40), H66 (= H65), C100 (= C101), C103 (= C104), C111 (= C112), C153 (≠ D156)
1rjwA Crystal structure of NAD(+)-dependent alcohol dehydrogenase from bacillus stearothermophilus strain lld-r (see paper)
35% identity, 99% coverage: 3:356/356 of query aligns to 1:337/339 of 1rjwA
- active site: C38 (= C40), H39 (≠ R41), T40 (= T42), H43 (≠ Q45), H61 (= H65), E62 (= E66), C92 (≠ D98), C95 (= C101), C98 (= C104), C106 (= C112), K110 (≠ V116), C148 (≠ D156), T152 (= T160), R331 (= R350)
- binding trifluoroethanol: T40 (= T42), C148 (≠ D156), I285 (≠ F304)
- binding zinc ion: C38 (= C40), H61 (= H65), C92 (≠ D98), C95 (= C101), C98 (= C104), C106 (= C112)
6n7lC Crystal structure of an alcohol dehydrogenase from elizabethkingia anophelis nuhp1
35% identity, 99% coverage: 3:353/356 of query aligns to 8:340/344 of 6n7lC
- active site: C45 (= C40), T47 (= T42), H50 (≠ Q45), H68 (= H65), C154 (≠ D156)
- binding nicotinamide-adenine-dinucleotide: C45 (= C40), H46 (≠ R41), T47 (= T42), H50 (≠ Q45), C154 (≠ D156), T158 (= T160), G178 (= G184), G180 (= G186), G181 (= G187), L182 (= L188), D201 (≠ A209), V202 (≠ R210), K206 (= K214), T243 (≠ C256), A244 (= A257), V245 (≠ G258), S246 (= S259), A249 (≠ S262), N266 (≠ V279), G267 (= G280), L268 (= L281), I291 (≠ F304), V292 (≠ W305)
- binding zinc ion: C45 (= C40), H68 (= H65), C98 (≠ D98), C101 (= C101), C104 (= C104), C112 (= C112), C154 (≠ D156)
3piiA Crystal structure of mutant of ht- alcohol dehydrogenase with substrate analogue butyramide
35% identity, 99% coverage: 3:356/356 of query aligns to 1:337/337 of 3piiA
- active site: C38 (= C40), H39 (≠ R41), T40 (= T42), H43 (≠ Q45), H61 (= H65), E62 (= E66), C92 (≠ D98), C95 (= C101), C98 (= C104), C106 (= C112), K110 (≠ V116), C148 (≠ D156), T152 (= T160), R331 (= R350)
- binding butyramide: T40 (= T42), H61 (= H65), W87 (= W96), C148 (≠ D156)
- binding zinc ion: C38 (= C40), H61 (= H65), E62 (= E66), C92 (≠ D98), C95 (= C101), C98 (= C104), C106 (= C112), C148 (≠ D156)
2h6eA Crystal structure of the d-arabinose dehydrogenase from sulfolobus solfataricus (see paper)
35% identity, 88% coverage: 18:330/356 of query aligns to 14:314/323 of 2h6eA
- active site: C36 (= C40), R37 (= R41), T38 (= T42), R41 (≠ Q45), H60 (= H65), E61 (= E66), D89 (= D98), C92 (= C101), C95 (= C104), C103 (= C112), I107 (≠ V116), D145 (= D156), T149 (= T160)
- binding zinc ion: C36 (= C40), H60 (= H65), D89 (= D98), C92 (= C101), C95 (= C104), C103 (= C112), D145 (= D156)
Sites not aligning to the query:
3s2fE Crystal structure of furx nadh:furfural
35% identity, 99% coverage: 3:353/356 of query aligns to 3:336/340 of 3s2fE
- active site: C40 (= C40), H41 (≠ R41), T42 (= T42), H45 (≠ Q45), H63 (= H65), E64 (= E66), C94 (≠ D98), C97 (= C101), C100 (= C104), C108 (= C112), Q112 (≠ V116), C150 (≠ D156), T154 (= T160), R333 (= R350)
- binding furfural: T42 (= T42), W51 (≠ N53), H63 (= H65), W89 (= W96), C150 (≠ D156), I287 (≠ F304)
- binding nicotinamide-adenine-dinucleotide: C40 (= C40), H41 (≠ R41), T42 (= T42), C150 (≠ D156), T154 (= T160), G174 (= G184), G176 (= G186), G177 (= G187), L178 (= L188), D197 (≠ A209), I198 (≠ R210), K202 (= K214), T239 (≠ C256), A240 (= A257), V241 (≠ G258), N262 (≠ V279), G263 (= G280), L264 (= L281), I287 (≠ F304), V288 (≠ W305), R333 (= R350)
- binding zinc ion: C40 (= C40), H63 (= H65), C94 (≠ D98), C97 (= C101), C100 (= C104), C108 (= C112), C150 (≠ D156)
3s2fA Crystal structure of furx nadh:furfural
35% identity, 99% coverage: 3:353/356 of query aligns to 3:336/340 of 3s2fA
- active site: C40 (= C40), H41 (≠ R41), T42 (= T42), H45 (≠ Q45), H63 (= H65), E64 (= E66), C94 (≠ D98), C97 (= C101), C100 (= C104), C108 (= C112), Q112 (≠ V116), C150 (≠ D156), T154 (= T160), R333 (= R350)
- binding phosphorylisopropane: T42 (= T42), H63 (= H65), W89 (= W96), I287 (≠ F304)
- binding zinc ion: C40 (= C40), H63 (= H65), E64 (= E66), C94 (≠ D98), C97 (= C101), C100 (= C104), C108 (= C112), C150 (≠ D156)
3s2eE Crystal structure of furx nadh complex 1
35% identity, 99% coverage: 3:353/356 of query aligns to 3:336/340 of 3s2eE
- active site: C40 (= C40), H41 (≠ R41), T42 (= T42), H45 (≠ Q45), H63 (= H65), E64 (= E66), C94 (≠ D98), C97 (= C101), C100 (= C104), C108 (= C112), Q112 (≠ V116), C150 (≠ D156), T154 (= T160), R333 (= R350)
- binding nicotinamide-adenine-dinucleotide: C40 (= C40), H41 (≠ R41), T42 (= T42), C150 (≠ D156), T154 (= T160), G176 (= G186), G177 (= G187), L178 (= L188), D197 (≠ A209), I198 (≠ R210), K202 (= K214), T239 (≠ C256), A240 (= A257), V241 (≠ G258), S242 (= S259), A245 (≠ S262), N262 (≠ V279), G263 (= G280), L264 (= L281), I287 (≠ F304), V288 (≠ W305)
- binding zinc ion: C40 (= C40), H63 (= H65), C94 (≠ D98), C97 (= C101), C100 (= C104), C108 (= C112), C150 (≠ D156)
3s2eA Crystal structure of furx nadh complex 1
35% identity, 99% coverage: 3:353/356 of query aligns to 3:336/340 of 3s2eA
- active site: C40 (= C40), H41 (≠ R41), T42 (= T42), H45 (≠ Q45), H63 (= H65), E64 (= E66), C94 (≠ D98), C97 (= C101), C100 (= C104), C108 (= C112), Q112 (≠ V116), C150 (≠ D156), T154 (= T160), R333 (= R350)
- binding zinc ion: C40 (= C40), H63 (= H65), E64 (= E66), C94 (≠ D98), C97 (= C101), C100 (= C104), C108 (= C112), C150 (≠ D156)
1r37A Alcohol dehydrogenase from sulfolobus solfataricus complexed with NAD(h) and 2-ethoxyethanol (see paper)
33% identity, 99% coverage: 3:354/356 of query aligns to 1:346/347 of 1r37A
- active site: C38 (= C40), H39 (≠ R41), S40 (≠ T42), H43 (≠ Q45), H68 (= H65), E69 (= E66), E98 (≠ D98), C101 (= C101), C104 (= C104), C112 (= C112), R116 (≠ V116), C154 (≠ D156), T158 (= T160), R342 (= R350)
- binding 2-ethoxyethanol: S40 (≠ T42), F49 (= F51)
- binding nicotinamide-adenine-dinucleotide: C38 (= C40), H39 (≠ R41), S40 (≠ T42), H43 (≠ Q45), C154 (≠ D156), T158 (= T160), G181 (= G187), G182 (≠ L188), L183 (≠ G189), D203 (≠ A209), V204 (≠ R210), R205 (≠ S211), L247 (≠ C256), N248 (≠ A257), V270 (= V279), G271 (= G280), L272 (= L281), F273 (≠ I282), L295 (≠ F304), V296 (≠ W305), L334 (≠ I342), F337 (≠ G345), R342 (= R350)
- binding zinc ion: C38 (= C40), H68 (= H65), E98 (≠ D98), C101 (= C101), C104 (= C104), C112 (= C112), C154 (≠ D156)
1jvbA Alcohol dehydrogenase from the archaeon sulfolobus solfataricus (see paper)
33% identity, 99% coverage: 3:354/356 of query aligns to 1:346/347 of 1jvbA
- active site: C38 (= C40), H39 (≠ R41), S40 (≠ T42), H43 (≠ Q45), H68 (= H65), E69 (= E66), E98 (≠ D98), C101 (= C101), C104 (= C104), C112 (= C112), R116 (≠ V116), C154 (≠ D156), T158 (= T160), R342 (= R350)
- binding zinc ion: C38 (= C40), H68 (= H65), E69 (= E66), E98 (≠ D98), C101 (= C101), C104 (= C104), C112 (= C112), C154 (≠ D156)
P39462 NAD-dependent alcohol dehydrogenase; EC 1.1.1.1 from Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) (Sulfolobus solfataricus) (see paper)
33% identity, 99% coverage: 3:354/356 of query aligns to 1:346/347 of P39462
- K11 (≠ Q13) modified: N6-methyllysine; partial
- K213 (= K219) modified: N6-methyllysine; partial
P12311 Alcohol dehydrogenase; ADH-T; EC 1.1.1.1 from Geobacillus stearothermophilus (Bacillus stearothermophilus) (see paper)
35% identity, 99% coverage: 3:356/356 of query aligns to 1:337/337 of P12311
- C38 (= C40) mutation to S: No activity.
- T40 (= T42) mutation to A: No activity.; mutation to S: Little decrease in activity.
- H43 (≠ Q45) mutation to A: No activity.; mutation to R: Higher level of activity at pH 9.
6iqdA Crystal structure of alcohol dehydrogenase from geobacillus stearothermophilus (see paper)
34% identity, 99% coverage: 3:353/356 of query aligns to 1:334/336 of 6iqdA
- active site: C38 (= C40), T40 (= T42), H43 (≠ Q45), H61 (= H65), C148 (≠ D156)
- binding zinc ion: C38 (= C40), H61 (= H65), E62 (= E66), C92 (≠ D98), C95 (= C101), C98 (= C104), C106 (= C112), C148 (≠ D156)
4z6kA Alcohol dehydrogenase from the antarctic psychrophile moraxella sp. Tae 123
34% identity, 99% coverage: 3:355/356 of query aligns to 1:336/345 of 4z6kA
- active site: C38 (= C40), H39 (≠ R41), T40 (= T42), H43 (≠ Q45), H61 (= H65), E62 (= E66), C92 (≠ D98), C95 (= C101), C98 (= C104), C106 (= C112), Q110 (≠ V116), C148 (≠ D156), T152 (= T160), R331 (= R350)
- binding zinc ion: C38 (= C40), H61 (= H65), C92 (≠ D98), C95 (= C101), C98 (= C104), C106 (= C112), C148 (≠ D156)
Q8GIX7 Alcohol dehydrogenase; ADH; EC 1.1.1.1 from Moraxella sp. (strain TAE123) (see paper)
34% identity, 99% coverage: 3:355/356 of query aligns to 1:336/338 of Q8GIX7
- C38 (= C40) binding Zn(2+)
- H61 (= H65) binding Zn(2+)
- E62 (= E66) binding Zn(2+)
- C92 (≠ D98) binding Zn(2+)
- C95 (= C101) binding Zn(2+)
- C98 (= C104) binding Zn(2+)
- C106 (= C112) binding Zn(2+)
- C148 (≠ D156) binding Zn(2+)
2xaaA Alcohol dehydrogenase adh-'a' from rhodococcus ruber dsm 44541 at ph 8.5 in complex with NAD and butane-1,4-diol (see paper)
34% identity, 95% coverage: 18:354/356 of query aligns to 12:332/333 of 2xaaA
- active site: C34 (= C40), H35 (≠ R41), S36 (≠ T42), F39 (≠ Q45), H57 (= H65), E58 (= E66), C80 (≠ D98), C83 (= C101), C86 (= C104), C94 (= C112), A98 (vs. gap), D141 (= D156), T145 (= T160), R328 (= R350)
- binding nicotinamide-adenine-dinucleotide: H35 (≠ R41), D141 (= D156), G169 (= G186), G170 (= G187), L171 (= L188), D191 (≠ A209), L192 (≠ R210), R196 (≠ K214), S211 (≠ V229), F234 (≠ C256), V235 (≠ A257), V257 (= V279), Y282 (= Y301), R328 (= R350)
- binding zinc ion: C34 (= C40), H57 (= H65), C80 (≠ D98), C83 (= C101), C86 (= C104), C94 (= C112), D141 (= D156)
Query Sequence
>WP_011782575.1 NCBI__GCF_000015305.1:WP_011782575.1
MKMRAARMYGYKQPLRLEEVDVPSPGPEEVLVRVGGAGMCRTDFQLIDGYFDNGLSMDFP
ITPGHEVAGWVDGVGSAVPKSAGLAEGDQVVVFGSWGDGACRQCHEGNEQLCAHGVWAGF
GRHGGYQEYLPVNYRYLIKIPGGGELSPDNLAPLTDAGLTPYRGLKKLRNAGHLGPGRTV
AVSGIGGLGSYATQYAKLLGGGAEVVAFARSDEKLKIAKDNGADHVVNVRDKDTEDVRAE
LESATGRTELDAVIECAGSEDSIRLAFSLLAAEGAVASVGLIGNRVDIPLFPLVAREYTF
YGSFWGNYNDLTEVLALARTGQLKHSVTRVRFDDVNETLEAIARGDVLGRAVIVYD
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory