SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing WP_011812426.1 NCBI__GCF_000015565.1:WP_011812426.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 1 hits to proteins with known functional sites (download)

P68183 Maltose/maltodextrin transport system permease protein MalG from Escherichia coli (strain K12) (see 2 papers)
31% identity, 52% coverage: 69:206/264 of query aligns to 87:229/296 of P68183

query
sites
P68183

N

N

S

S

M

V

L

K

V

V

A

A

C

G

V

I

A

S

T

A

V

I

V

G

S

I

T

V

V

A

F

L

A

S

G

T

M

T

A

C

A

A

L

Y

A

A

M

F

A

A

R

R

R

M

N

R

F

F

K

P

G

G

Q

K

-

A

N

T

V

L

I

L

S

K

G

G

M

M

L

L

G

I

L

F

P

Q

L

M

L

F

V

-

P

P

E

A

I

V

V

L

T

S

A

L

V

V

A

A

S

L

L

Y

L

A

F

L

F

F

L

D

S

R

L

L

G

G

M

E

D

Y

L

I

-

P

-

F

-

I

G

G

L

L

R

N

T

T

V

H

T

G

I

-

A

-

H

-

I

-

V

-

F

-

C

G

I

V

P

I

F

F

A

A

Y

Y

L

L

-

G

-

G

-

I

-

A

-

L

-

H

-

V

-

W

P

T

I

I

R

K

A

G

R

Y

L

F

A

E

N

T

M

I

D

D

P

S

R

S

L

L

V

E

E
|
E

A

A

A
|
A

A

A

D

L

L

D

Y
x
G

A

A

S

T

P

P

G

W

Q

Q

A

A

F

F

R

R

R

L

I

V

T

L

L

L

P
|
P

L

L

L

S

M

V

P

P

G

I

I

L

I

A

S

V

G

V

A

F

M

I

L

L

A

S

F

F

I

I

V

A

S

A

L

I

D

T

D

E

E190 (= E167) mutation E->A,C,K,L: Reduction of transport rate.
A192 (= A169) mutation A->D,S,L: Loss of transport and MalK dissociation from the membrane.
G196 (≠ Y173) mutation to A: No effect.; mutation to P: Loss of transport and MalK dissociation from the membrane.
P209 (= P186) mutation to A: No effect.

Query Sequence

>WP_011812426.1 NCBI__GCF_000015565.1:WP_011812426.1
MTHRNTALWRFPGLGLNFGIALVFLYLPIVLLVLLSFNENNVATLWTGLSLRWYGIVFDN
PNILRAAGNSMLVACVATVVSTVFAGMAALAMARRNFKGQNVISGMLGLPLLVPEIVTAV
ASLLFFLSLGMDLGLRTVTIAHIVFCIPFAYLPIRARLANMDPRLVEAAADLYASPGQAF
RRITLPLLMPGIISGAMLAFIVSLDDFVITFFVAGPGATTLPVYIFGMVRMGITPEVNAL
AALLLIASMVFVGLSWWIGQRDRR

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory