SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing WP_011813840.1 NCBI__GCF_000015585.1:WP_011813840.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

P0A799 Phosphoglycerate kinase; EC 2.7.2.3 from Escherichia coli (strain K12) (see 3 papers)
62% identity, 99% coverage: 1:390/394 of query aligns to 1:385/387 of P0A799

query
sites
P0A799

M
|
M

K

S

A

V

K

I

R

K

M

M

T

T

D

D

L

L

D

D

L

L

T

A

G

G

K

K

R

R

V

V

L

F

I

I

R

R

E

A

D

D

L

L

N

N

V

V

P

P

I

V

K

K

D

D

G

G

Q

K

V

V

A

T

D

S

D

D

T

A

R

R

V

I

R

R

A

A

A

S

A

L

E

P

S

T

I

I

R

E

Q

L

A

A

M

L

Q

K

A

Q

G

G

G

A

R

K

V

V

L

M

V

V

M

T

S

S

H

H

L

L

G

G

R

R

P

P

K

T

E

E

G

G

E

E

Y

Y

D

N

A

E

E

E

A

F

S

S

M

L

A

L

P

P

V

V

A

V

R

N

R

Y

L

L

G

K

E

D

I
x
K

L

L

G

S

C

N

E

P

V

V

P

R

V

L

V

V

R

K

D

D

W

Y

L

L

E

D

G

G

V

V

D

D

V

V

P

A

E

E

G

G

G

E

V

L

A

V

L

V

A

L

E

E

N

N

V

V

R

R

F

F

Q

N

P

K

G

G

E

E

T

K

K

K

D

D

D

D

E

E

A

T

L

L

S

S

R

K

R

K

M

Y

A

A

A

A

L

L

C

C

D

D

V

V

F

F

V

V

M

M

D

D

A

A

F

F

G

G

T

T

A

A

H

H

R

R

A

A

Q

Q

A

A

S

S

T

T

H

H

G

G

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I

A

G

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K

F

F

A

A

P

D

E

V

A

A

C

C

A

A

G

G

P

P

L

L

L

L

S

A

A

A

E

E

L

L

E

D

A

A

L

L

G

G

K

K

A

A

L

L

D

K

N

E

P

P

A

A

R

R

P

P

M

M

I

V

A

A

I

I

V

V

G

G

G

G

S

S

K

K

V

V

S

S

G

T

K

K

V

L

Q

T

V

V

L

L

E

D

A

S

L

L

T

S

H

K

K

I

V

A

D

D

Q

Q

L

L

I

I

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V

G

G

G

G

G

G

I

I

A

A

N

N

T

T

F

F

I

I

A

A

A

A

A

Q

G

G

Y

H

S

D

V

V

G

G

K

K

S

S

L

L

Y

Y

E

E

A

A

D

D

F

L

V

V

D

D

T

E

A

A

K

K

R

R

L

L

M

L

E

T

E

T

A

C

R

N

A

-

K

-

G

-

G

-

E

-

I

I

P

P

I

V

P

P

E

S

D

D

V

V

V

R

T

V

A

A

R

T

D

E

F

F

S

S

A

E

D

T

A

A

E

P

A

A

H

T

V

L

H

K

P

S

V

V

D

N

A

D

V

V

P

K

D

A

D

D

E

E

M

Q

I

I

L

L

D

D

V

I

G

G

P

D

Q

A

T

S

R

A

A

Q

R

E

Y

L

D

A

G

E

M

I

L

L

R

K

N

N

A

A

G

K

T

T

V

I

V

L

W

W

N

N

G

G

P

P

V

V

G

G

V

V

F

F

E

E

M

F

A

P

P

N

F

F

A

R

G

K

G

G

T

T

R

E

A

I

L

V

A

A

E

N

A

A

I

I

A

A

A

D

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S

D

E

G

A

F

F

S

S

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I

A

A

G

G

G

G

G

G

D

D

T

T

L

L

A

A

A

A

V

I

E

D

Q

L

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F

G

G

I

I

T

A

D

D

Q

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V

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Y

Y

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I

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S

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T

G

G

G

G

G

G

A

A

F

F

L

L

E

E

F

F

L

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E

E

G

G

R

K

V

V

L

L

P

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A

A

M1 (= M1) modified: Initiator methionine, Removed
K84 (≠ I84) modified: N6-acetyllysine

1zmrA Crystal structure of the e. Coli phosphoglycerate kinase (see paper)
62% identity, 98% coverage: 5:390/394 of query aligns to 4:384/386 of 1zmrA

query
sites
1zmrA

R

K

M

M

T

T

D

D

L

L

D

D

L

L

T

A

G

G

K

K

R

R

V

V

L

F

I

I

R

R

E

A

D

D

L

L

N

N

V

V

P

P

I

V

K

K

D

D

G

G

Q

K

V

V

A

T

D

S

D

D

T

A

R
|
R

V

I

R

R

A

A

A

S

A

L

E

P

S

T

I

I

R

E

Q

L

A

A

M

L

Q

K

A

Q

G

G

G

A

R

K

V

V

L

M

V

V

M

T

S

S

H

H

L

L

G

G

R

R

P

P

K

T

E

E

G

G

E

E

Y

Y

D

N

A

E

E

E

A

F

S

S

M

L

A

L

P

P

V

V

A

V

R

N

R

Y

L

L

G
x
K

E

D

I

K

L
|
L

G

S

C

N

E

P

V

V

P

R

V

L

V

V

R

K

D

D

W

Y

L

L

E

D

G

G

V

V

D

D

V

V

P

A

E

E

G

G

G

E

V

L

A

V

L

V

A

L

E

E

N

N

V

V

R

R

F

F

Q

N

P

K

G

G

E

E

T

K

K

K

D

D

D

D

E

E

A

T

L

L

S

S

R

K

R

K

M

Y

A

A

A

A

L

L

C

C

D

D

V

V

F

F

V

V

M

M

D

D

A

A

F

F

G

G

T

T

A

A

H

H

R

R

A

A

Q

Q

A

A

S

S

T

T

H

H

G

G

V

I

A

G

R

K

F

F

A

A

P

D

E

V

A

A

C

C

A

A

G

G

P

P

L

L

L

L

S

A

A

A

E

E

L

L

E

D

A

A

L

L

G

G

K

K

A

A

L

L

D

K

N

E

P

P

A

A

R

R

P

P

M

M

I

V

A

A

I

I

V

V

G

G

G

G

S

S

K
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K

V

V

S

S

G

T

K

K

V

L

Q

T

V

V

L

L

E

D

A

S

L

L

T

S

H

K

K

I

V

A

D

D

Q

Q

L

L

I

I

V

V

G

G

G

G

G

G

I

I

A

A

N

N

T

T

F

F

I

I

A

A

A

A

A

Q

G

G

Y

H

S

D

V

V

G

G

K

K

S

S

L

L

Y

Y

E

E

A

A

D
|
D

F

L

V

V

D
|
D

T

E

A

A

K

K

R

R

L

L

M

L

E

T

E

T

A

C

R

N

A

-

K

-

G

-

G

-

E

-

I

I

P

P

I

V

P

P

E

S

D

D

V

V

V

R

T

V

A

A

R

T

D

E

F

F

S

S

A

E

D

T

A

A

E

P

A

A

H

T

V

L

H

K

P

S

V

V

D

N

A

D

V

V

P

K

D

A

D

D

E

E

M

Q

I

I

L

L

D

D

V

I

G

G

P

D

Q

A

T

S

R

A

A

Q

R

E

Y

L

D

A

G

E

M

I

L

L

R

K

N

N

A

A

G

K

T

T

V

I

V

L

W

W

N

N

G

G

P

P

V

V

G

G

V

V

F

F

E

E

M

F

A

P

P

N

F

F

A

R

G

K

G

G

T

T

R

E

A

I

L

V

A

A

E

N

A

A

I

I

A

A

A

D

S

S

D

E

G

A

F

F

S

S

I

I

A

A

G

G

G

G

G
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G

D

D

T

T

L

L

A

A

A

A

V

I

E

D

Q

L

F

F

G

G

I

I

T

A

D

D

Q

K

V

I

S

S

Y

Y

I

I

S

S

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T

G

G

G

G

G
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G

A

A

F

F

L

L

E

E

F

F

L

V

E

E

G

G

R

K

V

V

L

L

P

P

G

A

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A

A

A

M

L

L

E

E

Q

E

H

R

A

A

active site: R35 (= R36), K192 (= K193), G340 (= G346), G363 (= G369)
binding calcium ion: K81 (≠ G82), L84 (= L85), D236 (= D237), D239 (= D240)

4ng4B Structure of phosphoglycerate kinase (cbu_1782) from coxiella burnetii (see paper)
56% identity, 98% coverage: 6:390/394 of query aligns to 5:388/389 of 4ng4B

query
sites
4ng4B

M

M

T

S

D

N

L

L

D

N

L

L

T

H

G

N

K

K

R

R

V

V

L

M

I

I

R

R

E

E

D

D

L

L

N

N

V

V

P

P

I

M

K

K

D

N

G

G

Q

K

V

I

A

T

D

N

D

D

T

E

R
|
R

V

I

R

V

A

R

A

A

A

L

E

P

S

T

I

I

R

Q

Q

K

A

A

M

I

Q

E

A

Q

G

K

G

A

R

R

V

V

L

M

V

I

M

L

S

S

H

H

L

L

G

G

R

R

P

P

K

E

E

E

G

G

E

K

Y

F

D

E

A

K

E

E

A

F

S

S

M

L

A

A

P

P

V

V

A

A

R

R

R

L

L

L

G

S

E

K

I

K

L

L

G

N

C

-

E

K

V

V

P

P

V

L

V

I

R

N

D

D

W

W

L

L

E

K

G

G

V

V

D

A

V

V

P

E

E

P

G

G

G

Q

V

A

A

I

L

L

A

C

E

E

N

N

V

V

R

R

F

F

Q

N

P

K

G

G

E

E

T

N

K

E

D

N

D

N

E

T

A

E

L

L

S

A

R

K

R

R

M

M

A

A

A

E

L

L

C

C

D

D

V

I

F

F

V

V

M

M

D

D

A

A

F

F

G

A

T

T

A

A

H

H

R

R

A

A

Q

Q

A

A

S

S

T

T

H

A

G

G

V

V

A

A

R

A

F

Y

A

A

P

K

E

L

A

A

C

C

A

A

G

G

P

P

L

L

L

L

S

I

A

S

E

E

L

V

E

E

A

A

L

L

G

S

K

R

A

A

L

L

D

E

N

N

P

P

A

Q

R

K

P

P

M

L

I

V

A

A

I

V

V

V

G

G

G
|
G

S

S

K
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K

V

V

S

S

G

T

K
|
K

V

I

Q

H

V

L

L

L

E

E

A

N

L

L

T

L

H

D

K

K

V

V

D

D

Q

Q

L

L

I

I

V

V

G

G

G
|
G

G

G

I

I

A

A

N

N

T

T

F

F

I

L

A

K

A

A

A

Q

G

G

Y

Y

S

S

V

I

G

G

K

K

S

S

L

L

Y

C

E

E

A

N

D

E

F

W

V

L

D

D

T

A

A

A

K

Q

R

Q

L

F

M

W

E

E

E

K

A

A

R

A

A

E

K

K

G

N

G

V

E

S

I

L

P

P

I

L

P

P

E

V

D

D

V

V

V

I

T

V

A

A

R

D

D

E

F

L

S

S

A

E

D

D

A

A

E

K

A

A

H

T

V

V

H

K

P

N

V

I

D

D

A

A

V

V

P

T

D

S

D

N

E

E

M

S

I
|
I

L

F

D
|
D

V

V

G

G

P

P

Q

N

T

T

R

S

A

A

R

T

Y

Y

D

A

G

K

M

L

L

M

R

A

N

Q

A

A

G

G

T

T

V

I

V

V

W

W

N
|
N

G
|
G

P
|
P

V

I

G
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G

V
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V

F

F

E
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E

M

I

A

E

P

A

F
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F

A
x
S

G

Q

G

G

T
|
T

R

R

A

A

L

L

A

A

E

Q

A

A

I

V

A

A

A

K

S

S

D

T

G

A

F

Y

S

S

I

I

A

V

G

G

G
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G

G
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G

D
|
D

T
|
T

L

L

A

A

A

A

V

L

E

D

Q

K

F

F

G

N

I

L

T

T

D

D

Q

Q

V

M

S

S

Y

Y

I

V

S

S

T

T

G

A

G

G

G
|
G

A

A

F

F

L

L

E

E

F

F

L

L

E

E

G

G

R

K

V

I

L

L

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A

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A

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A

A

active site: R35 (= R36), K191 (= K193), G344 (= G346), G367 (= G369)
binding adenosine-5'-diphosphate: G189 (= G191), K195 (= K197), G213 (= G215), I286 (= I288), N310 (= N312), G311 (= G313), P312 (= P314), V315 (= V317), E317 (= E319), G343 (= G345), D345 (= D347), T346 (= T348)
binding magnesium ion: D288 (= D290), G314 (= G316), F321 (= F323), S322 (≠ A324), T325 (= T327)

4feyA An x-ray structure of a putative phosphogylcerate kinase with bound adp from francisella tularensis subsp. Tularensis schu s4
56% identity, 99% coverage: 1:390/394 of query aligns to 1:390/392 of 4feyA

query
sites
4feyA

M

M

K

S

A

F

K

L

R

T

M

L

T

K

D

D

L

V

D

D

L

L

T

K

G

D

K

K

R

K

V

V

L

L

I

V

R

R

E

V

D

D

L

F

N

N

V

V

P

P

I

V

K

K

D

D

G

G

Q

K

V

V

A

T

D

S

D

K

T

V

R
|
R

V

I

R

E

A

A

A

A

A

I

E

P

S

T

I

I

R

Q

Q

Y

A

I

M

L

Q

D

A

Q

G

G

G

G

R

A

V

V

L

I

V

L

M

M

S

S

H

H

L

L

G

G

R

R

P

P

K

T

E

E

G

G

E

E

Y

Y

D

D

A

S

E

Q

A

F

S

S

M

L

A

E

P

P

V

V

A

A

R

K

R

A

L

L

G

S

E

E

I

I

L

I

G

N

C

K

E

P

V

V

P

K

V

F

V

A

R

K

D

D

W

W

L

L

E

D

G

G

V

V

D

D

V

V

P

K

E

A

G

G

G

E

V

I

A

V

L

M

A

C

E

E

N

N

V

V

R

R

F

F

Q

N

P

S

G

G

E

E

T

K

K

K

D

S

D

T

E

D

A

D

L

L

S

S

R

K

R

K

M

I

A

A

A

S

L

L

C

G

D

D

V

V

F

F

V

V

M

M

D

D

A

A

F

F

G

A

T

T

A

A

H

H

R

R

A

A

Q

Q

A

A

S

S

T

T

H

Y

G

G

V

V

A

A

R

K

F

Y

A

I

P

P

E

V

A

A

C

C

A

A

G

G

P

I

L

L

L

L

S

T

A

N

E

E

L

I

E

Q

A

A

L

L

G

E

K

K

A

A

L

L

D

K

N

S

P

P

A

K

R

K

P

P

M

M

I

A

A

A

I

I

V

V

G

G

G
|
G

S
|
S

K
|
K

V

V

S

S

G

T

K
|
K

V

L

Q

S

V

V

L

L

E

N

A

N

L

L

T

L

H

D

K

K

V

V

D

E

Q

I

L

L

I

I

V

V

G

G

G
|
G

G

G

I

I

A

A

N

N

T

T

F

F

I

I

A

K

A

A

A

E

G

G

Y

F

S

D

V

V

G

G

K

N

S

S

L

L

Y

Y

E

E

A

Q

D

D

F

L

V

V

D

A

T

E

A

A

K

T

R

E

L

I

M

L

E

A

E

K

A

A

R

K

A

A

K

L

G

G

G

V

E

N

I

I

P

P

I

V

P

P

E

V

D

D

V

V

V

R

T

V

A

A

R

K

D

E

F

F

S

S

A

E

D

N

A

A

E

Q

A

A

H

I

V

I

H

K

P

K

V

V

D

S

A

D

V

V

P

V

D

A

D

D

E

E

M

M

I

I

L

L

D

D

V

I

G

G

P

P

Q

E

T

S

R

Q

A

K

R

I

Y

I

D

A

G

E

M

L

L

L

R

K

N

S

A

A

G

N

T

T

V

I

V

L

W

W

N

N

G

G

P

P

V

V

G
|
G

V
|
V

F

F

E
|
E

M

F

A

D

P

N

F

F

A

A

G

E

G

G

T

T

R

K

A

A

L

L

A

S

E

L

A

A

I

I

A

A

A

Q

S

S

D

H

G

A

F

F

S

S

I

V

A

A

G

G

G

G

G
|
G

D
|
D

T

T

L

I

A

A

A

A

V

I

E

E

Q

K

F

F

G

G

I

I

T

K

D

D

Q

Q

V

V

S

S

Y

Y

I

I

S

S

T

T

G

A

G

G

G
|
G

A

A

F

F

L

L

E

E

F

F

L

L

E

E

G

G

R

K

V

K

L

L

P

P

G

A

V

I

A

E

A

I

L

L

E

K

Q

E

H

K

A

A

active site: R36 (= R36), K193 (= K193), G346 (= G346), G369 (= G369)
binding adenosine-5'-diphosphate: G191 (= G191), S192 (= S192), K197 (= K197), G215 (= G215), G316 (= G316), V317 (= V317), E319 (= E319), D347 (= D347)

P40924 Phosphoglycerate kinase; EC 2.7.2.3 from Bacillus subtilis (strain 168) (see paper)
52% identity, 98% coverage: 1:386/394 of query aligns to 1:391/394 of P40924

query
sites
P40924

M

M

K

N

A

K

K

K

R

T

M

L

T

K

D

D

L

I

D

D

L

V

T

K

G

G

K

K

R

V

V

V

L

F

I

C

R

R

E

V

D

D

L

F

N

N

V

V

P

P

I

M

K

K

D

D

G

G

Q

E

V

V

A

T

D

D

D

D

T

T

R

R

V

I

R

R

A

A

A

A

A

L

E

P

S

T

I

I

R

K

Q

H

A

L

M

A

Q

D

A

Q

G

G

G

A

R

K

V

V

L

L

V

L

M

A

S

S

H

H

L

L

G

G

R

R

P

P

K

K

E

-

G

G

E

E

Y

V

D

V

A

E

E

E

A

L

S

R

M

L

A

T

P

P

V

V

A

A

R

A

R

R

L

L

G

G

E

E

I

L

L

L

G

G

C

K

E

E

V

V

P

K

V

K

V

A

R

D

D

E

-

A

W

Y

L

G

E

D

G

A

V

V

-

K

-

A

-

Q

-

I

-

S

D

E

V

M

P

K

E

D

G

G

G

D

V

V

A

L

L

V

A

L

E

E

N

N

V

V

R

R

F

F

Q

Y

P

P

G

G

E

E

T

E

K

K

D

N

D

D

E

P

A

E

L

L

S

A

R

K

R

A

M

F

A

A

A

E

L

L

C

A

D

D

V

V

F

Y

V

V

M

N

D

D

A

A

F

F

G

G

T

A

A

A

H

H

R

R

A

A

Q

H

A

A

S

S

T

T

H

A

G

G

V

I

A

A

R

E

F

H

A

L

P

P

E

-

A

A

C

V

A

A

G

G

P

F

L

L

L

M

S

E

A

K

E

E

L

L

E

D

A

V

L

L

G

G

K

K

A

A

L

V

D
x
S

N

N

P

P

A

D

R

R

P

P

M

F

I

T

A

A

I

I

V

I

G

G

G

G

S

A

K

K

V

V

S

K

G

D

K

K

V

I

Q

G

V

V

L

I

E

E

A

S

L

L

T

L

H

D

K

K

V

V

D

D

Q

N

L

L

I

I

V

I

G

G

G

G

G

G

I

L

A

A

N

Y

T

T

F

F

I

V

A

K

A

A

A

L

G

G

Y

Y

S

E

V

V

G

G

K

K

S

S

L

L

Y

L

E

E

A

E

D

D

F

K

V

I

D

E

T

L

A

A

K

K

R

S

L

F

M

M

E

D

E

R

A

A

R

K

A

E

K

K

G

G

G

V

E

N

I

F

P

Y

I

M

P

P

E

E

D

D

V

V

V

L

T

V

A

A

R

D

D

D

F

F

S

S

A

N

D

D

A

A

E

N

A

V

H

K

V

I

H

V

P

P

V

I

D

S

A

E

V

I

P

P

D

S

D

D

E

L

M

E

I

A

L

I

D

D

V

I

G

G

P

T

Q

K

T
|
T

R

R

A

E

R

T

Y

Y

D

A

G

D

M

V

L

I

R

K

N

N

A

S

G

K

T

L

V

V

V

V

W

W

N

N

G

G

P

P

V

M

G

G

V

V

F

F

E

E

M

I

A

D

P

L

F

F

A

A

G

Q

G

G

T

T

R

K

A

A

L

V

A

A

E

E

A

A

I

L

A

A

-

E

A

A

S

K

D

D

G

T

F

Y

S

S

I

V

A

I

G

G

G

G

G

G

D

D

T

S

L

A

A

A

A

A

V

V

E

E

Q

K

F

F

G

G

I

L

T

A

D

D

Q

K

V

M

S

S

Y

H

I

I

S

S

T

T

G

G

G

G

G

G

A

A

F

S

L

L

E

E

F

F

L

M

E

E

G

G

R

K

V

E

L

L

P

P

G

G

V

V

A

A

A

A

L

L

S183 (≠ D179) modified: Phosphoserine
T299 (= T295) modified: Phosphothreonine

1phpA Structure of the adp complex of the 3-phosphoglycerate kinase from bacillus stearothermophilus at 1.65 angstroms (see paper)
50% identity, 98% coverage: 1:387/394 of query aligns to 1:392/394 of 1phpA

query
sites
1phpA

M

M

K

N

A

K

K

K

R

T

M

I

T

R

D

D

L

V

D

D

L

V

T

R

G

G

K

K

R

R

V

V

L

F

I

C

R

R

E

V

D

D

L

F

N

N

V

V

P

P

I

M

K

E

D

Q

G

G

Q

A

V

I

A

T

D

D

D

D

T

T

R
|
R

V

I

R

R

A

A

A

A

A

L

E

P

S

T

I

I

R

R

Q

Y

A

L

M

I

Q

E

A

H

G

G

G

A

R

K

V

V

L

I

V

L

M

A

S

S

H

H

L

L

G

G

R

R

P

P

K

K

E

-

G

G

E

K

Y

V

D

V

A

E

E

E

A

L

S

R

M

L

A

D

P

A

V

V

A

A

R

K

R

R

L

L

G

G

E

E

I

L

L

L

-

E

-

R

-

P

-

V

-

A

-

K

-

T

-

N

-

E

-

A

-

V

G

G

C

D

E

E

V

V

P

K

V

A

V

A

R

V

D

D

W

R

L

L

E

N

G

-

V

-

D

-

V

-

P

-

E

E

G

G

G

D

V

V

A

L

L

L

A

L

E

E

N

N

V

V

R

R

F

F

Q

Y

P

P

G

G

E

E

T

E

K

K

D

N

D

D

E

P

A

E

L

L

S

A

R

K

R

A

M

F

A

A

A

E

L

L

C

A

D

D

V

L

F

Y

V

V

M

N

D

D

A

A

F

F

G

G

T

A

A

A

H

H

R

R

A

A

Q

H

A

A

S

S

T

T

H

E

G

G

V

I

A

A

R

H

F

Y

A

L

P

P

E

-

A

A

C

V

A

A

G

G

P

F

L

L

L

M

S

E

A

K

E

E

L

L

E

E

A

V

L

L

G

G

K

K

A

A

L

L

D

S

N

N

P

P

A

D

R

R

P

P

M

F

I

T

A

A

I

I

V

I

G

G

G
|
G

S

A

K
|
K

V

V

S

K

G

D

K
|
K

V

I

Q

G

V

V

L

I

E

D

A

N

L

L

T

L

H

E

K

K

V

V

D

D

Q

N

L

L

I

I

V

I

G

G

G
|
G

G
|
G

I

L

A

A

N

Y

T

T

F

F

I

V

A

K

A

A

A

L

G

G

Y

H

S

D

V

V

G

G

K

K

S

S

L
|
L

Y

L

E

E

A

E

D

D

F

K

V

I

D

E

T

L

A

A

K

K

R

S

L

F

M

M

E

E

E

K

A

A

R

K

A

E

K

K

G

G

G

V

E

R

I

F

P

Y

I

M

P

P

E

V

D

D

V

V

V

V

T

V

A

A

R

D

D

R

F

F

S

A

A

N

D

D

A

A

E

N

A

T

H

K

V

V

H

V

P

P

V

I

D

D

A

A

V

I

P

P

D

A

D

D

E

W

M

S

I

A

L

L

D

D

V

I

G

G

P

P

Q

K

T

T

R

R

A

E

R

L

Y

Y

D

R

G

D

M

V

L

I

R

R

N

E

A

S

G

K

T

L

V

V

V

V

W

W

N
|
N

G

G

P
|
P

V

M

G
|
G

V
|
V

F

F

E
|
E

M

M

A

D

P

A

F

F

A

A

G

H

G

G

T

T

R

K

-

A

A

I

L

A

A

E

E

A

A

L

I

A

A

E

A

A

S

L

D

D

G

T

F

Y

S

S

I

V

A

I

G

G

G
|
G

G
|
G

D
|
D

T
x
S

L

A

A

A

A

A

V

V

E

E

Q

K

F

F

G

G

I

L

T

A

D

D

Q

K

V

M

S

D

Y

H

I

I

S

S

T

T

G

G

G

G

G
|
G

A

A

F

S

L

L

E

E

F

F

L

M

E

E

G

G

R

K

V

Q

L

L

P

P

G

G

V

V

A

V

A

A

L

L

E

E

active site: R36 (= R36), K197 (= K193), G351 (= G346), G374 (= G369)
binding adenosine-5'-diphosphate: G195 (= G191), K201 (= K197), G219 (= G215), G220 (= G216), L237 (= L233), N316 (= N312), P318 (= P314), G320 (= G316), V321 (= V317), E323 (= E319), G350 (= G345), D352 (= D347), S353 (≠ T348)

P18912 Phosphoglycerate kinase; EC 2.7.2.3 from Geobacillus stearothermophilus (Bacillus stearothermophilus) (see paper)
50% identity, 98% coverage: 1:387/394 of query aligns to 1:392/394 of P18912

query
sites
P18912

M

M

K

N

A

K

K

K

R

T

M

I

T

R

D

D

L

V

D

D

L

V

T

R

G

G

K

K

R

R

V

V

L

F

I

C

R

R

E

V

D

D

L

F

N

N

V

V

P

P

I

M

K

E

D

Q

G

G

Q

A

V

I

A

T

D

D

D

D

T

T

R

R

V

I

R

R

A

A

A

A

A

L

E

P

S

T

I

I

R

R

Q

Y

A

L

M

I

Q

E

A

H

G

G

G

A

R

K

V

V

L

I

V

L

M

A

S

S

H

H

L

L

G

G

R

R

P

P

K

K

E

-

G

G

E

K

Y

V

D

V

A

E

E

E

A

L

S

R

M

L

A

D

P

A

V

V

A

A

R

K

R

R

L

L

G

G

E

E

I

L

L

L

-

E

-

R

-

P

-

V

-

A

-

K

-

T

-

N

-

E

-

A

-

V

G

G

C

D

E

E

V

V

P

K

V

A

V

A

R

V

D

D

W

R

L

L

E

N

G

-

V

-

D

-

V

-

P

-

E

E

G

G

G

D

V

V

A

L

L

L

A

L

E

E

N

N

V

V

R

R

F

F

Q

Y

P

P

G

G

E

E

T

E

K

K

D

N

D

D

E

P

A

E

L

L

S

A

R

K

R

A

M

F

A

A

A

E

L

L

C

A

D

D

V

L

F

Y

V

V

M

N

D

D

A

A

F

F

G

G

T

A

A

A

H

H

R

R

A

A

Q

H

A

A

S

S

T

T

H

E

G

G

V

I

A

A

R

H

F

Y

A

L

P

P

E

-

A

A

C

V

A

A

G

G

P

F

L

L

L

M

S

E

A

K

E

E

L

L

E

E

A

V

L

L

G

G

K

K

A

A

L

L

D

S

N

N

P

P

A

D

R

R

P

P

M

F

I

T

A

A

I

I

V

I

G

G

G

G

S

A

K

K

V

V

S

K

G

D

K
|
K

V

I

Q

G

V

V

L

I

E

D

A

N

L

L

T

L

H

E

K

K

V

V

D

D

Q

N

L

L

I

I

V

I

G

G

G

G

G

G

I

L

A

A

N

Y

T

T

F

F

I

V

A

K

A

A

A

L

G

G

Y

H

S

D

V

V

G

G

K

K

S

S

L

L

Y

L

E

E

A

E

D

D

F

K

V

I

D

E

T

L

A

A

K

K

R

S

L

F

M

M

E

E

E

K

A

A

R

K

A

E

K

K

G

G

G

V

E

R

I

F

P

Y

I

M

P

P

E

V

D

D

V

V

V

V

T

V

A

A

R

D

D

R

F

F

S

A

A

N

D

D

A

A

E

N

A

T

H

K

V

V

H

V

P

P

V

I

D

D

A

A

V

I

P

P

D

A

D

D

E

W

M

S

I

A

L

L

D

D

V

I

G

G

P

P

Q

K

T

T

R

R

A

E

R

L

Y

Y

D

R

G

D

M

V

L

I

R

R

N

E

A

S

G

K

T

L

V

V

V

V

W

W

N
|
N

G

G

P

P

V

M

G

G

V

V

F

F

E
|
E

M

M

A

D

P

A

F

F

A

A

G

H

G

G

T

T

R

K

-

A

A

I

L

A

A

E

E

A

A

L

I

A

A

E

A

A

S

L

D

D

G

T

F

Y

S

S

I

V

A

I

G

G

G
|
G

G
|
G

D
|
D

T
x
S

L

A

A

A

A

A

V

V

E

E

Q

K

F

F

G

G

I

L

T

A

D

D

Q

K

V

M

S

D

Y

H

I

I

S

S

T

T

G

G

G

G

G

G

A

A

F

S

L

L

E

E

F

F

L

M

E

E

G

G

R

K

V

Q

L

L

P

P

G

G

V

V

A

V

A

A

L

L

E

E

K201 (= K197) binding ATP
N316 (= N312) binding ATP
E323 (= E319) binding ATP
GGDS 350:353 (≠ GGDT 345:348) binding ATP

P36204 Bifunctional PGK/TIM; EC 2.7.2.3; EC 5.3.1.1 from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see paper)
48% identity, 98% coverage: 1:386/394 of query aligns to 1:394/654 of P36204

query
sites
P36204

M

M

K

E

A

K

K

M

R

T

M

I

T

R

D

D

L

V

D

D

L

L

T

K

G

G

K

K

R

R

V

V

L

I

I

M

R

R

E

V

D

D

L

F

N

N

V

V

P

P

I

V

K

K

D

D

G

G

Q

V

V

V

A

Q

D

D

D

D

T

T

R
|
R

V

I

R

R

A

A

A

A

A

L

E

P

S

T

I

I

R

K

Q

Y

A

A

M

L

Q

E

A

Q

G

G

G

A

R

K

V

V

L

I

V

L

M

L

S

S

H

H

L

L

G

G

R

R

P

P

K

K

E

-

G

G

E

E

Y

P

D

S

A

P

E

E

A

F

S

S

M

L

A

A

P

P

V

V

A

A

R

K

R

R

L

L

G

S

E

E

I

L

L

L

G

G

C

K

E

E

V

V

P

K

-

F

-

V

-

P

-

A

V

V

V

V

R

G

D

D

W

E

L

V

E

K

G

K

V

A

-

V

-

E

D

E

V

L

P

K

E

E

G

G

G

E

V

V

A

L

L

L

A

L

E

E

N

N

V

T

R
|
R

F

F

Q

H

P

P

G

G

E

E

T

T

K

K

D

N

D

D

E

P

A

E

L

L

S

A

R

K

R

F

M

W

A

A

A

S

L

L

C

A

D

D

V

I

F

H

V

V

M

N

D

D

A

A

F

F

G

G

T

T

A

A

H

H

R
|
R

A

A

Q

H

A

A

S

S

T

N

H

V

G

G

V

I

A

A

R

Q

F

F

A

I

P

P

E

-

A

S

C

V

A

A

G

G

P

F

L

L

L

M

S

E

A

K

E

E

L

I

E

K

A

F

L

L

G

S

K

K

A

V

L

T

D

Y

N

N

P

P

A

E

R

K

P

P

M

Y

I

V

A

V

I

V

V

L

G

G

G

G

S

A

K

K

V

V

S

S

G

D

K

K

V

I

Q

G

V

V

L

I

E

T

A

N

L

L

T

M

H

E

K

K

V

A

D

D

Q

R

L

I

I

L

V

I

G

G

G

G

G

A

I

M

A

M

N

F

T

T

F

F

I

L

A

K

A

A

A

L

G

G

Y

K

S

E

V

V

G

G

K

S

S

S

L

R

Y

V

E

E

A

E

D

D

F

K

V

I

D

D

T

L

A

A

K

K

R

E

L

L

M

L

E

E

E

K

A

A

R

K

A

E

K

K

G

G

G

V

E

E

I

I

P

V

I

L

P

P

E

V

D

D

V

A

V

V

T

I

A

A

R

Q

D

K

F

I

S

E

A

P

D

G

A

V

E

E

A

K

H

K

V

V

H

V

P

R

V

I

-

D

D

D

A

G

V

I

P

P

D

E

D

G

E

W

M

M

I

G

L

L

D

D

V

I

G

G

P

P

Q

E

T

T

R

I

A

E

R

L

Y

F

D

K

G

Q

M

K

L

L

R

S

N

D

A

A

G

K

T

T

V

V

V

V

W

W

N

N

G

G

P

P

V

M

G

G

V

V

F

F

E

E

M

I

A

D

P

D

F

F

A

A

G

E

G

G

T

T

R

K

A

Q

L

V

A

A

E

L

A

A

I

I

A

A

A

A

-

L

-

T

-

E

S

K

D

G

G

A

F

I

S

T

I

V

A

V

G

G

G

G

G

G

D

D

T

S

L

A

A

A

A

A

V

V

E

N

Q

K

F

F

G

G

I

L

T

E

D

D

Q

K

V

F

S

S

Y

H

I

V

S

S

T

T

G

G

G

G

G

G

A

A

F

S

L

L

E

E

F

F

L

L

E

E

G

G

R

K

V

E

L

L

P

P

G

G

V

I

A

A

A

S

L

I

R36 (= R36) binding substrate
R118 (= R113) binding substrate
R151 (= R146) binding substrate

1vpeA Crystallographic analysis of phosphoglycerate kinase from the hyperthermophilic bacterium thermotoga maritima (see paper)
48% identity, 97% coverage: 4:386/394 of query aligns to 1:393/398 of 1vpeA

query
sites
1vpeA

K

E

R

K

M

M

T

T

-

I

-

R

D

D

L

V

D

D

L

L

T

K

G

G

K

K

R

R

V

V

L

I

I

M

R

R

E

V

D

D

L

F

N

N

V

V

P

P

I

V

K

K

D

D

G

G

Q

V

V

V

A

Q

D

D

D

D

T

T

R
|
R

V

I

R

R

A

A

A

A

A

L

E

P

S

T

I

I

R

K

Q

Y

A

A

M

L

Q

E

A

Q

G

G

G

A

R

K

V

V

L

I

V

L

M

L

S

S

H

H

L

L

G

G

R

R

P

P

K

K

E

-

G

G

E

E

Y

P

D

S

A

P

E

E

A

F

S

S

M

L

A

A

P

P

V

V

A

A

R

K

R

R

L

L

G

S

E

E

I

L

L

L

G

G

C

K

E

E

V

V

P

K

-

F

-

V

-

P

-

A

V

V

V

V

R

G

D

D

W

E

L

V

E

K

G

K

V

A

-

V

-

E

D

E

V

L

P

K

E

E

G

G

G

E

V

V

A

L

L

L

A

L

E

E

N

N

V

T

R

R

F

F

Q

H

P

P

G

G

E

E

T

T

K

K

D

N

D

D

E

P

A

E

L

L

S

A

R

K

R

F

M

W

A

A

A

S

L

L

C

A

D

D

V

I

F

H

V

V

M

N

D

D

A

A

F

F

G

G

T

T

A

A

H

H

R

R

A

A

Q

H

A

A

S

S

T

N

H

V

G

G

V

I

A

A

R

Q

F

F

A

I

P

P

E

-

A

S

C

V

A

A

G

G

P

F

L

L

L

M

S

E

A

K

E

E

L

I

E

K

A

F

L

L

G

S

K

K

A

V

L

T

D

Y

N

N

P

P

A

E

R

K

P

P

M

Y

I

V

A

V

I

V

V

L

G

G

G
|
G

S
x
A

K
|
K

V

V

S

S

G

D

K
|
K

V

I

Q

G

V

V

L

I

E

T

A

N

L

L

T

M

H

E

K

K

V

A

D

D

Q

R

L

I

I

L

V

I

G

G

G
|
G

G
x
A

I

M

A

M

N

F

T

T

F

F

I

L

A

K

A

A

A

L

G

G

Y

K

S

E

V

V

G

G

K

S

S

S

L

R

Y

V

E

E

A

E

D

D

F

K

V

I

D

D

T

L

A

A

K

K

R

E

L

L

M

V

E

E

E

K

A

A

R

K

A

E

K

K

G

G

G

V

E

E

I

I

P

V

I

L

P

P

E

V

D

D

V

A

V

V

T

I

A

A

R

Q

D

K

F

I

S

E

A

P

D

G

A

V

E

E

A

K

H

K

V

V

H

V

P

R

V

I

-

D

D

D

A

G

V

I

P

P

D

E

D

G

E

W

M

M

I

G

L

L

D

D

V

I

G

G

P

P

Q

E

T

T

R

I

A

E

R

L

Y

F

D

K

G

Q

M

K

L

L

R

S

N

D

A

A

G

K

T

T

V

V

V

V

W

W

N
|
N

G

G

P
|
P

V

M

G
|
G

V
|
V

F

F

E
|
E

M

I

A

D

P

D

F

F

A

A

G

E

G

G

T

T

R

K

A

Q

L

V

A

A

E

L

A

A

I

I

A

A

A

A

-

L

-

T

-

E

S

K

D

G

G

A

F

I

S

T

I

V

A

V

G

G

G
|
G

G
|
G

D
|
D

T
x
S

L

A

A

A

A

A

V

V

E

N

Q

K

F

F

G

G

I

L

T

E

D

D

Q

K

V

F

S

S

Y

H

I

V

S

S

T

T

G

G

G

G

G
|
G

A

A

F

S

L

L

E

E

F

F

L

L

E

E

G

G

R

K

V

E

L

L

P

P

G

G

V

I

A

A

A

S

L

M

active site: R35 (= R36), K196 (= K193), G353 (= G346), G376 (= G369)
binding phosphoaminophosphonic acid-adenylate ester: G194 (= G191), A195 (≠ S192), K196 (= K193), K200 (= K197), G218 (= G215), A219 (≠ G216), N316 (= N312), P318 (= P314), G320 (= G316), V321 (= V317), E323 (= E319), G352 (= G345), G353 (= G346), D354 (= D347), S355 (≠ T348)

16pkA Phosphoglycerate kinase from trypanosoma brucei bisubstrate analog (see paper)
39% identity, 97% coverage: 4:387/394 of query aligns to 3:413/415 of 16pkA

query
sites
16pkA

K

K

R

S

M

I

T

N

D

E

L

C

D

D

L

L

T

K

G

G

K

K

R

K

V

V

L

L

I

I

R

R

E

V

D

D

L

F

N

N

V

V

P

P

I

V

K

K

D

N

G

G

Q

K

V

I

A

T

D

N

D

D

T

Y

R
|
R

V

I

R

R

A

S

A

A

A

L

E

P

S

T

I

L

R

K

Q

K

A

V

M

L

Q

T

A

E

G

G

G

G

R

S

V

C

L

V

V

L

M

M

S

S

H

H

L

L

G

G

R

R

P

P

K

K

-

G

-

I

-

P

-

M

-

A

-

Q

E

A

G

G

E

K

-

I

-

R

-

S

-

T

-

G

-

G

-

V

-

P

-

G

Y

F

D

Q

A

Q

E

K

A

A

S

T

M

L

A

K

P

P

V

V

A

A

R

K

R

R

L

L

G

S

E

E

I

L

L

L

G

L

C

R

E

P

V

V

P

T

V

F

V

A

R

P

D

D

W

C

L

L

E

N

G

A

V

A

D

D

V

V

-

V

-

S

-

K

-

M

P

S

E

P

G

G

G

D

V

V

A

V

L

L

A

L

E

E

N

N

V

V

R

R

F

F

Q

Y

P

K

G

E

E

E

-

G

-

S

-

K

-

K

T

A

K

K

D

D

D

R

E

E

A

A

L

M

S

A

R

K

R

I

M

L

A

A

A

S

L

Y

C

G

D

D

V

V

F

Y

V

I

M

S

D

D

A

A

F

F

G

G

T

T

A

A

H

H

R

R

A

D

Q

S

A

A

S

T

T

M

H

T

G

G

V

I

A

P

R

K

F

I

A

L

P

G

E

N

A

G

C

A

A

A

G

G

P

Y

L

L

L

M

S

E

A

K

E

E

L

I

E

S

A

Y

L

F

G

A

K

K

A

V

L

L

D

G

N

N

P

P

A

P

R

R

P

P

M

L

I

V

A

A

I

I

V

V

G

G

G
|
G

S
x
A

K
|
K

V

V

S

S

G

D

K
|
K

V

I

Q

Q

V

L

L

L

E

D

A

N

L

M

T

L

H

Q

K

R

V

I

D

D

Q

Y

L

L

I

L

V

I

G

G

G

G

G
x
A

I

M

A

A

N
x
Y

T

T

F

F

I

L

A

K

A

A

A

Q

G

G

Y

Y

S

S

V

I

G

G

K

K

S

S

L

K

Y

C

E

E

A

E

D

S

F

K

V

L

D

E

T

F

A

A

K

R

R

S

L

L

M

L

E

K

E

K

A

A

R

E

A

D

K

R

G

K

G

V

E

Q

I

V

P

I

I

L

P

P

E

I

D

D

V

H

V

V

T

C

A

H

R

T

D

E

F

F

S

K

A

A

D

V

A

D

E

S

A

P

H

L

V

I

H

T

P

E

V

D

D

Q

A

N

V

I

P

P

D

E

D

G

E

H

M

M

I

A

L
|
L

D

D

V

I

G

G

P

P

Q

K

T

T

R

I

A

E

R

K

Y

Y

D

V

G

Q

M

T

L

I

R

G

N

K

A

C

G

K

T

S

V

A

V

I

W

W

N

N

G

G

P
|
P

V

M

G
|
G

V
|
V

F

F

E
|
E

M

M

A

V

P

P

F

Y

A

S

G

K

G

G

T

T

R

F

A

A

L

I

A

A

E

K

A

A

I

M

A

G

A

R

S

G

D

T

G

H

-

E

-

H

-

G

-

L

F

M

S

S

I

I

A

I

G

G

G

G

G
|
G

D

D

T

S

L

A

A

S

A

A

V

A

E

E

Q

L

F

S

G

G

I

E

T

A

D

K

Q

R

V

M

S

S

Y

H

I

V

S

S

T

T

G
|
G

G
|
G

G
|
G

A

A

F

S

L

L

E

E

F

L

L

L

E

E

G

G

R

K

V

T

L

L

P

P

G

G

V

V

A

T

A

V

L

L

E

D

active site: R35 (= R36), K215 (= K193), G372 (= G346), G395 (= G369)
binding 1,1,5,5-tetrafluorophosphopentylphosphonic acid adenylate ester: G213 (= G191), A214 (≠ S192), K219 (= K197), A238 (≠ G216), Y241 (≠ N219), L311 (= L289), P336 (= P314), G338 (= G316), V339 (= V317), E341 (= E319), G393 (= G367), G394 (= G368), G395 (= G369)

13pkA Ternary complex of phosphoglycerate kinase from trypanosoma brucei (see paper)
39% identity, 97% coverage: 4:387/394 of query aligns to 3:413/415 of 13pkA

query
sites
13pkA

K

K

R

S

M

I

T

N

D

E

L

C

D

D

L

L

T

K

G

G

K

K

R

K

V

V

L

L

I

I

R

R

E

V

D

D

L

F

N

N

V

V

P

P

I

V

K

K

D

N

G

G

Q

K

V

I

A

T

D

N

D

D

T

Y

R
|
R

V

I

R

R

A

S

A

A

A

L

E

P

S

T

I

L

R

K

Q

K

A

V

M

L

Q

T

A

E

G

G

G

G

R

S

V

C

L

V

V

L

M

M

S

S

H

H

L

L

G

G

R

R

P

P

K

K

-

G

-

I

-

P

-

M

-

A

-

Q

E

A

G

G

E

K

-

I

-

R

-

S

-

T

-

G

-

G

-

V

-

P

-

G

Y

F

D

Q

A

Q

E

K

A

A

S

T

M

L

A

K

P

P

V

V

A

A

R

K

R

R

L

L

G

S

E

E

I

L

L

L

G

L

C

R

E

P

V

V

P

T

V

F

V

A

R

P

D

D

W

C

L

L

E

N

G

A

V

A

D

D

V

V

-

V

-

S

-

K

-

M

P

S

E

P

G

G

G

D

V

V

A

V

L

L

A

L

E

E

N

N

V

V

R

R

F

F

Q

Y

P

K

G

E

E

E

-

G

-

S

-

K

-

K

T

A

K

K

D

D

D

R

E

E

A

A

L

M

S

A

R

K

R

I

M

L

A

A

A

S

L

Y

C

G

D

D

V

V

F

Y

V

I

M

S

D

D

A

A

F

F

G

G

T

T

A

A

H

H

R

R

A

D

Q

S

A

A

S

T

T

M

H

T

G

G

V

I

A

P

R

K

F

I

A

L

P

G

E

N

A

G

C

A

A

A

G

G

P

Y

L

L

L

M

S

E

A

K

E

E

L

I

E

S

A

Y

L

F

G

A

K

K

A

V

L

L

D

G

N

N

P

P

A

P

R

R

P

P

M

L

I

V

A

A

I

I

V

V

G

G

G
|
G

S
x
A

K
|
K

V

V

S

S

G

D

K
|
K

V

I

Q

Q

V

L

L

L

E

D

A

N

L

M

T

L

H

Q

K

R

V

I

D

D

Q

Y

L

L

I

L

V

I

G

G

G

G

G

A

I

M

A

A

N

Y

T

T

F

F

I

L

A

K

A

A

A

Q

G

G

Y

Y

S

S

V

I

G

G

K

K

S

S

L

K

Y

C

E

E

A

E

D

S

F

K

V

L

D

E

T

F

A

A

K

R

R

S

L

L

M

L

E

K

E

K

A

A

R

E

A

D

K

R

G

K

G

V

E

Q

I

V

P

I

I

L

P

P

E

I

D

D

V

H

V

V

T

C

A

H

R

T

D

E

F

F

S

K

A

A

D

V

A

D

E

S

A

P

H

L

V

I

H

T

P

E

V

D

D

Q

A

N

V

I

P

P

D

E

D

G

E

H

M

M

I

A

L
|
L

D

D

V

I

G

G

P

P

Q

K

T

T

R

I

A

E

R

K

Y

Y

D

V

G

Q

M

T

L

I

R

G

N

K

A

C

G

K

T

S

V

A

V

I

W

W

N

N

G

G

P
|
P

V

M

G
|
G

V
|
V

F

F

E
|
E

M

M

A

V

P

P

F

Y

A

S

G

K

G

G

T

T

R

F

A

A

L

I

A

A

E

K

A

A

I

M

A

G

A

R

S

G

D

T

G

H

-

E

-

H

-

G

-

L

F

M

S

S

I

I

A

I

G

G

G
|
G

G
|
G

D
|
D

T
x
S

L

A

A

S

A

A

V

A

E

E

Q

L

F

S

G

G

I

E

T

A

D

K

Q

R

V

M

S

S

Y

H

I

V

S

S

T

T

G

G

G

G

G
|
G

A

A

F

S

L

L

E

E

F

L

L

L

E

E

G

G

R

K

V

T

L

L

P

P

G

G

V

V

A

T

A

V

L

L

E

D

active site: R35 (= R36), K215 (= K193), G372 (= G346), G395 (= G369)
binding adenosine-5'-diphosphate: G213 (= G191), A214 (≠ S192), K219 (= K197), L311 (= L289), P336 (= P314), G338 (= G316), V339 (= V317), E341 (= E319), G371 (= G345), D373 (= D347), S374 (≠ T348)

P07378 Phosphoglycerate kinase, glycosomal; Phosphoglycerate kinase C; EC 2.7.2.3 from Trypanosoma brucei brucei (see 2 papers)
39% identity, 99% coverage: 4:394/394 of query aligns to 7:424/440 of P07378

query
sites
P07378

K

K

R

S

M

I

T

N

D

E

L

C

D

D

L

L

T

K

G

G

K

K

R

K

V

V

L

L

I

I

R

R

E

V

D
|
D

L
x
F

N
|
N

V

V

P

P

I

V

K

K

D

N

G

G

Q

K

V

I

A

T

D

N

D

D

T

Y

R
|
R

V

I

R

R

A

S

A

A

A

L

E

P

S

T

I

L

R

K

Q

K

A

V

M

L

Q

T

A

E

G

G

G

G

R

S

V

C

L

V

V

L

M

M

S

S

H
|
H

L
|
L

G
|
G

R
|
R

P

P

K

K

-

G

-

I

-

P

-

M

-

A

-

Q

E

A

G

G

E

K

-

I

-

R

-

S

-

T

-

G

-

G

-

V

-

P

-

G

Y

F

D

Q

A

Q

E

K

A

A

S

T

M

L

A

K

P

P

V

V

A

A

R

K

R

A

L

L

G

S

E

E

I

L

L

L

G

L

C

R

E

P

V

V

P

T

V

F

V

A

R

P

D

D

W

C

L

L

E

N

G

A

V

A

D

D

V

V

-

V

-

S

-

K

-

M

P

S

E

P

G

G

G

D

V

V

A

V

L

L

A

L

E

E

N

N

V

V

R
|
R

F

F

Q

Y

P

K

G

E

E

E

-

G

-

S

-

K

-

K

T

A

K

K

D

D

D

R

E

E

A

A

L

M

S

A

R

K

R

I

M

L

A

A

A

S

L

Y

C

G

D

D

V

V

F

Y

V

I

M

S

D

D

A

A

F

F

G

G

T

T

A

A

H

H

R
|
R

A

D

Q

S

A

A

S

T

T

M

H

T

G

G

V

I

A

P

R

K

F

I

A

L

P

G

E

N

A

G

C

A

A

A

G

G

P

Y

L

L

L

M

S

E

A

K

E

E

L

I

E

S

A

Y

L

F

G

A

K

K

A

V

L

L

D

G

N

N

P

P

A

P

R

R

P