SitesBLAST – Find functional sites

 

SitesBLAST

Comparing WP_011814512.1 NCBI__GCF_000015585.1:WP_011814512.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 4 hits to proteins with known functional sites (download)

6j2lA Crystal structure of bi-functional enzyme (see paper)
40% identity, 89% coverage: 14:140/142 of query aligns to 9:133/200 of 6j2lA

query
sites
6j2lA
L
 
L
D
 
D
W
 
W
S
 
E
A
 
-
V
 
-
L
 
-
D
 
-
T
 
-
L
 
-
P
 
-
F
 
-
N
 
K
S
 
T
D
 
D
G
 
G
L
 
L
L
 
M
P
 
P
A
 
V
I
 
I
A
 
V
Q
 
Q
Q
 
H
H
 
A
D
 
V
S
 
S
N
 
G
E
 
E
V
 
V
L
 
L
M
 
M
L
 
L
A
 
G
W
 
Y
M
 
M
N
 
N
R
 
P
Q
 
E
A
 
A
L
 
L
E
 
D
E
 
K
T
 
T
L
 
I
Q
 
E
T
 
S
G
 
G
R
 
K
V
 
V
C
 
T
Y
 
F
Y
 
F
S
 
S
R
 
R
S
 
T
R
 
K
G
 
Q
T
 
R
L
 
L
W
 
W
R
 
I
K
 
K
G
 
G
E
 
E
S
 
T
S
 
S
G
 
G
Q
 
N
V
 
F
Q
 
L
H
 
N
L
 
V
H
 
V
E
 
S
L
 
I
R
 
A
L
 
P
D
|
D
C
 
C
D
|
D
G
 
N
D
|
D
T
 
T
L
 
L
L
 
L
L
 
V
R
 
L
V
 
A
D
 
N
Q
 
P
Q
 
I
G
 
G
P
 
P
A
 
T
C
|
C
H
 
H
T
 
K
G
 
G
R
 
T
R
 
S
S
 
S
C
|
C
F
 
F
Y
 
G
N
 
N
V
 
T
-
 
A
-
 
H
-
 
Q
-
 
W
-
 
L
-
 
F
L
 
L
Q
 
Y
G
 
Q
N
 
L
R
 
E
V
 
Q
V
 
L
V
 
L
S
 
A
E
 
E
P
 
R
P
 
K
Q
 
Y
V
 
A
D
 
D
P
 
P
Q
 
E
T
 
T
L
 
S
Y
 
Y

Sites not aligning to the query:

7bgnA Crystal structure of mthisn2-amp complex, a bifunctional enzyme from the histidine biosynthetic pathway (see paper)
37% identity, 79% coverage: 18:129/142 of query aligns to 4:116/204 of 7bgnA

query
sites
7bgnA
A
 
S
V
 
L
L
 
L
D
 
D
T
 
S
L
 
V
P
 
K
F
 
W
N
 
D
S
 
N
D
 
K
G
 
G
L
 
L
L
 
A
P
 
V
A
 
A
I
 
I
A
 
A
Q
 
Q
Q
 
N
H
 
V
D
 
D
S
 
T
N
 
G
E
 
A
V
 
I
L
 
L
M
 
M
L
 
Q
A
 
G
W
 
F
M
 
A
N
 
N
R
 
R
Q
 
E
A
 
A
L
 
V
E
 
A
E
 
T
T
 
T
L
 
I
Q
 
S
T
 
S
G
 
R
R
 
K
V
 
A
C
 
T
Y
 
F
Y
 
Y
S
 
S
R
 
R
S
 
S
R
 
R
G
 
S
T
 
S
L
 
L
W
|
W
R
 
T
K
|
K
G
|
G
E
 
E
S
x
T
S
|
S
G
 
N
Q
 
N
V
 
F
Q
 
I
H
 
N
L
 
V
H
 
H
E
 
D
L
 
V
R
 
F
L
 
L
D
|
D
C
 
C
D
|
D
G
 
R
D
|
D
T
 
S
L
 
I
L
 
I
L
 
Y
R
 
L
V
 
G
D
 
K
Q
 
P
Q
 
D
G
 
G
P
 
P
A
x
T
C
|
C
H
|
H
T
 
T
G
 
G
R
 
A
R
 
E
S
 
T
C
|
C
F
 
Y
Y
 
Y
N
 
T
-
 
P
V
 
V
L
 
F
Q
 
D
G
 
L
N
 
N
R
 
K
V
 
L
V
 
A
V
 
L
S
 
T

Sites not aligning to the query:

7bgmA Crystal structure of mthisn2, a bifunctional enzyme from the histidine biosynthetic pathway (see paper)
40% identity, 71% coverage: 18:118/142 of query aligns to 6:106/213 of 7bgmA

query
sites
7bgmA
A
 
S
V
 
L
L
 
L
D
 
D
T
 
S
L
 
V
P
 
K
F
 
W
N
 
D
S
 
N
D
 
K
G
 
G
L
 
L
L
 
A
P
 
V
A
 
A
I
 
I
A
 
A
Q
 
Q
Q
 
N
H
 
V
D
 
D
S
 
T
N
 
G
E
 
A
V
 
I
L
 
L
M
 
M
L
 
Q
A
 
G
W
 
F
M
 
A
N
 
N
R
 
R
Q
 
E
A
 
A
L
 
V
E
 
A
E
 
T
T
 
T
L
 
I
Q
 
S
T
 
S
G
 
R
R
 
K
V
 
A
C
 
T
Y
 
F
Y
 
Y
S
 
S
R
 
R
S
 
S
R
 
R
G
 
S
T
 
S
L
 
L
W
 
W
R
 
T
K
 
K
G
 
G
E
 
E
S
 
T
S
 
S
G
 
N
Q
 
N
V
 
F
Q
 
I
H
 
N
L
 
V
H
 
H
E
 
D
L
 
V
R
 
F
L
 
L
D
|
D
C
 
C
D
|
D
G
 
R
D
|
D
T
 
S
L
 
I
L
 
I
L
 
Y
R
 
L
V
 
G
D
 
K
Q
 
P
Q
 
D
G
 
G
P
 
P
A
 
T
C
|
C
H
 
H
T
 
T
G
 
G
R
 
A
R
 
E
S
 
T
C
|
C
F
 
Y
Y
 
Y

Sites not aligning to the query:

6j2lB Crystal structure of bi-functional enzyme (see paper)
42% identity, 75% coverage: 14:119/142 of query aligns to 8:99/185 of 6j2lB

query
sites
6j2lB
L
 
L
D
 
D
W
 
W
S
 
E
A
 
-
V
 
-
L
 
-
D
 
-
T
 
-
L
 
-
P
 
-
F
 
-
N
 
K
S
 
T
D
 
D
G
 
G
L
 
L
L
 
M
P
 
P
A
 
V
I
 
I
A
 
V
Q
 
Q
Q
 
H
H
 
A
D
 
V
S
 
S
N
 
G
E
 
E
V
 
V
L
 
L
M
 
M
L
 
L
A
 
G
W
 
Y
M
 
M
N
 
N
R
 
P
Q
 
E
A
 
A
L
 
L
E
 
D
E
 
K
T
 
T
L
 
I
Q
 
E
T
 
S
G
 
G
R
 
K
V
 
V
C
 
T
Y
 
F
Y
 
F
S
 
S
R
 
R
S
 
T
R
 
K
G
 
Q
T
 
R
L
 
L
W
 
W
R
 
I
K
 
K
G
 
G
E
 
E
S
 
T
S
 
S
G
 
G
Q
 
N
V
 
F
Q
 
L
H
 
N
L
 
V
H
 
V
E
 
S
L
 
I
R
 
A
L
 
P
D
|
D
C
 
C
D
|
D
G
 
N
D
|
D
T
 
T
L
 
L
L
 
L
L
 
V
R
 
L
V
 
A
D
 
N
Q
 
P
Q
 
I
G
 
G
P
 
P
A
 
S
C
 
-
H
 
-
T
 
-
G
 
-
R
 
-
R
 
-
S
 
S
C
 
C
F
 
F
Y
 
G
N
 
N

Sites not aligning to the query:

Query Sequence

>WP_011814512.1 NCBI__GCF_000015585.1:WP_011814512.1
MIEQNETARPGDGLDWSAVLDTLPFNSDGLLPAIAQQHDSNEVLMLAWMNRQALEETLQT
GRVCYYSRSRGTLWRKGESSGQVQHLHELRLDCDGDTLLLRVDQQGPACHTGRRSCFYNV
LQGNRVVVSEPPQVDPQTLYGP

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory