Comparing WP_011814631.1 NCBI__GCF_000015585.1:WP_011814631.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 14 hits to proteins with known functional sites (download)
P0A7B5 Glutamate 5-kinase; Gamma-glutamyl kinase; GK; EC 2.7.2.11 from Escherichia coli (strain K12) (see paper)
39% identity, 98% coverage: 7:373/376 of query aligns to 1:365/367 of P0A7B5
2j5tD Glutamate 5-kinase from escherichia coli complexed with glutamate (see paper)
40% identity, 97% coverage: 10:373/376 of query aligns to 2:363/365 of 2j5tD
2j5vB Glutamate 5-kinase from escherichia coli complexed with glutamyl-5- phosphate and pyroglutamic acid (see paper)
36% identity, 97% coverage: 10:373/376 of query aligns to 2:323/325 of 2j5vB
2j5vA Glutamate 5-kinase from escherichia coli complexed with glutamyl-5- phosphate and pyroglutamic acid (see paper)
36% identity, 97% coverage: 10:373/376 of query aligns to 2:321/323 of 2j5vA
2akoA Crystal structure of glutamate 5-kinase from campylobacter jejuni
32% identity, 67% coverage: 11:262/376 of query aligns to 1:240/241 of 2akoA
7wx3B Gk domain of drosophila p5cs filament with glutamate, atp, and NADPH (see paper)
32% identity, 70% coverage: 1:262/376 of query aligns to 3:256/258 of 7wx3B
7f5xA Gk domain of drosophila p5cs filament with glutamate (see paper)
38% identity, 49% coverage: 4:187/376 of query aligns to 6:184/236 of 7f5xA
8j0gB Gk monomer complexes with glutamate and atp
33% identity, 70% coverage: 4:265/376 of query aligns to 1:270/274 of 8j0gB
8j0eB Gk monomer complexes with catalytic intermediate
34% identity, 70% coverage: 2:265/376 of query aligns to 2:265/269 of 8j0eB
8j0fA Gk tetramer with adjacent hooks at reaction state (see paper)
33% identity, 70% coverage: 2:265/376 of query aligns to 3:264/270 of 8j0fA
3wwmA Crystal structure of lysz from thermus thermophilus with adp (see paper)
32% identity, 50% coverage: 75:261/376 of query aligns to 89:267/269 of 3wwmA
Sites not aligning to the query:
O50147 [LysW]-aminoadipate kinase; EC 2.7.2.17 from Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27) (see paper)
32% identity, 50% coverage: 75:261/376 of query aligns to 89:267/269 of O50147
Sites not aligning to the query:
3ll5A Crystal structure of t. Acidophilum isopentenyl phosphate kinase product complex (see paper)
38% identity, 17% coverage: 134:197/376 of query aligns to 122:186/233 of 3ll5A
Sites not aligning to the query:
3lkkB Crystal structure of the isopentenyl phosphate kinase substrate complex (see paper)
38% identity, 17% coverage: 134:197/376 of query aligns to 123:187/238 of 3lkkB
Sites not aligning to the query:
>WP_011814631.1 NCBI__GCF_000015585.1:WP_011814631.1
MRRREALRQAQRWVIKVGSALITDDGRGLAHEQMSAWADQVAALRKAGRQVTLVSSGAVA
EGMQRLGWRSRPRALYQLQAAAGVGQSGLVHAWSDGLARHRLQTAQVLLTHDDLSDRRRY
LNARSALREMLRLGVVPVVNENDTVVTDEIRFGDNDTLAALVANLVEAEALVVLTDQPGL
MDRDPREHPDAVLLDEVRAGDPELERLCGSPAGVLGRGGMLTKVRGAERAARSGTYTVVA
SGREGRVIQRLADAEPGLGTLFVPDQEPLAARKQWLASHLQTRGALSLDEGAARALRESG
KSLLPVGVVAVEGGFSRGEMVVCRDPAGIEVARGLVNYAAEEARLICGRASRDIETTLGY
VDEPELIHRDNMVVTV
Or try a new SitesBLAST search
SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory