SitesBLAST

P07547 Pentafunctional AROM polypeptide; EC 4.2.3.4; EC 2.5.1.19; EC 2.7.1.71; EC 4.2.1.10; EC 1.1.1.25 from Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) (Aspergillus nidulans) (see 2 papers)
39% identity, 90% coverage: 17:333/354 of query aligns to 16:372/1583 of P07547

query
sites
P07547

I

I

G

A

D

D

G

F

V

G

L

L

D

W

Q

R

G

N

V

Y

L

V

A

A

E

K

H

D

L

L

V

I

A

S

D

D

R

C

A

S

-

S

-

T

-

Y

L

V

L

L

V

V

S

T

N
x
D

E
x
T

T
x
N

V

I

A

G

P

S

L

I

Y

Y

A

T

E

P

R

S

L

F

A

E

-

E

-

A

-

F

-

R

-

K

-

A

-

E

-

I

V

T

P

P

G

S

A

P

E

R

V

L

Q

L

S

I

V

Y

T

N

L

A

H

P

D

P

G

G

E
|
E

R
x
V

Y
x
S

K
|
K

T

S

L

R

Q

Q

T

T

C

K

E

A

Q

D

V

I

Y

E

D

D

A

W

L

M

I

L

E

S

G

Q

R

N

-

P

F

C

D

G

R

R

S

D

A

T

T

V

V

V

I

I

A

A

L

L

G

G

G
|
G

V
|
V

V

I

G

G

D
|
D

M

L

A

T

G

G

F

F

C

V

A

A

A

S

T

T

Y

Y

Q

M

R

R

G

G

V

V

G

R

Y

Y

I

V

Q

Q

V

V

P

P

T
|
T

L

L

A

A

Q

M

V

V

D

D

S

S

V

I

G

G

K

K

T

T

G

A

V

I

N

D

H

T

P

P

R

L

G

G

K
|
K

N

N

M

L

I

I

G

G

A

A

F

I

H

W

Q

Q

P

P

R

T

A

K

V

I

V

Y

A

I

D

D

T

L

G

E

V
x
F

L
|
L

A
x
E

T
|
T

L

L

P

P

E

V

R

R

E

E

Y

F

N

I

A
x
N

G

G

L

M

A

A

E
|
E

V

V

V

I

K

K

Y

T

G

A

L

A

I

I

R

S

D

S

P

E

A

E

F

E

F

F

D

T

W

A

L

L

E

E

A

E

H

N

V

A

D

E

-

T

-

I

-

L

-

K

A

A

L

V

R

R

R

E

-

V

-

R

-

P

-

G

-

E

-

H

-

R

-

F

-

E

-

G

D

I

P

E

E

E

A

I

L

L

A

K

H

A

A

R

V

I

A

L

E

A

S

S

C

A

R

R

N

H

K

K

A

A

E

Y

V

V

A

S

A

A

D

D

E

E

R

R

E

E

A

G

G

G

E

L

R

R

A

N

L

L

N

N

L

W

G

G

H
|
H

T

S

F

I

G

G

H

H

A

A

I

I

E

E

T

A

Y

I

T

L

D

T

Y

-

C

P

T

Q

W

I

L

L

H
|
H

G

G

E

E

A

C

V

V

A

A

A

I

G

G

M

M

V

V

M

K

A

E

A

A

R

E

M

L

S

A

V

R

R

H

L

L

G

G

W

I

L

L

Q

K

R

G

N

V

G

A

L

V

E

S

R

R

T

I

I

V

A

K

L

C

L

L

E

A

A

A

F

Y

G

G

L

L

P

P

T

T

R

-

P

-

A

S

I

L

P

K

E

D

A

A

R

R

F

I

R

R

E

K

L

L

-

T

-

A

-

G

-

K

-

H

-

C

-

S

-

V

-

D

-

Q

-

L

-

M

-

F

-

N

M

M

S

A

V

L

D

D

K

K

N

N

R

D

G

G

G

P

Q

K

L

K

R

K

L

I

V

V

L

L

R

S

S

A

V

I

G

G

DTN 44:46 (≠ NET 41:43) binding NAD(+)
EVSK 81:84 (≠ ERYK 68:71) binding NAD(+)
GGV 114:116 (= GGV 99:101) binding NAD(+)
D119 (= D104) binding NAD(+)
TT 139:140 (= TT 124:125) binding NAD(+)
K161 (= K146) binding NAD(+)
FLET 179:182 (≠ VLAT 164:167) binding NAD(+)
N190 (≠ A175) binding NAD(+)
E194 (= E179) binding Zn(2+)
H271 (= H242) binding Zn(2+)
H287 (= H259) binding Zn(2+)

6hqvA Pentafunctional arom complex from chaetomium thermophilum (see paper)
43% identity, 75% coverage: 67:333/354 of query aligns to 75:365/1555 of 6hqvA

query
sites
6hqvA

G

G

E
|
E

R

Y

Y

S

K
|
K

T

S

L

R

Q

E

T

T

C

K

E

A

Q

E

V

I

Y

E

D

D

A

W

L

M

I

L

E

S

G

H

R

A

F

C

D

T

R

R

S

D

A

T

T

V

V

I

I

I

A

A

L

L

G

G

G
|
G

V
|
V

V

I

G

G

D
|
D

M

M

A

I

G

G

F

Y

C

V

A

A

T

T

Y

F

Q

M

R
|
R

G

G

V

V

G

R

Y

F

I

V

Q

Q

V

V

P

P

T
|
T

L

L

L
|
L

A

A

Q

M

V

V

D
|
D

S
|
S

S

S

V

I

G

G

K
|
K

T

T

G

A

V

I

N

D

H

T

P

P

R

M

G

G

K
|
K

N

N

M

L

I

I

G

G

A

A

F

F

H

W

Q

Q

P

P

R

R

A

R

V

I

V

Y

A

I

D

D

T

L

G

A

V

F

L

L

A

E

T
|
T

L
|
L

P
|
P

E

V

R

R

E
|
E

Y

F

N

I

A

N

G

G

L

M

A

A

E
|
E

V

V

V

I

K

K

Y

T

G

A

L

A

I

I

R

W

D

N

P

E

A

T

F

E

F

F

D

T

W

A

L

L

E

E

-

E

-

N

-

A

A

A

H

I

V

L

D

E

A

A

L

V

R

R

R

S

R

K

-

A

-

S

D

S

P

P

E

A

A

A

-

R

-

L

-

A

-

P

-

I

-

R

-

H

-

I

L

L

A

K

H

R

A

I

V

V

A

L

E

G

S

S

C

A

R

R

N

V

K
|
K

A

A

E

E

V

V

A

S

A

A

D

D

E

E

R

R

E
|
E

A

G

G

G

E

L

R
|
R

A

N

L

L

N
|
N

L

F

G

G

H
|
H

T

S

F

I

G

G

H
|
H

A

A

I

Y

E

E

T

A

Y

I

T

L

D

A

Y

P

C

Q

T

V

W

-

L

L

H
|
H

G

G

E

E

A

C

V

V

A

A

A

I

G

G

M

M

V

V

M

K

A

E

A

A

R

E

M

L

S

A

V

R

R

Y

L

L

G

G

W

V

L

L

Q

R

R

P

N

S

G

A

L

V

E

A

R

R

T

L

I

T

A

K

L

L

L

I

E

A

A

S

F

Y

G

D

L

L

P

P

T

T

R

-

P

-

A

S

I

V

P

H

E

D

A

K

R

R

F

I

R

A

E

K

L

L

-

S

-

A

-

G

-

K

-

E

-

C

-

P

-

V

-

D

-

V

-

L

-

Q

-

K

M

M

S

A

V

V

D

D

K

K

N

N

R

E

G

G

G

R

Q

K

L

K

R

K

L

I

V

V

L

L

R

S

S

A

V

I

G

G

active site: R123 (= R115), K145 (= K137), E187 (= E179), K243 (= K221), E253 (= E231), R257 (= R235), N261 (= N239), H264 (= H242), H268 (= H246), H280 (= H259)
binding glutamic acid: D139 (= D131), K145 (= K137), E187 (= E179), K243 (= K221), R257 (= R235), H264 (= H242), H280 (= H259)
binding nicotinamide-adenine-dinucleotide: E76 (= E68), K79 (= K71), G107 (= G99), G108 (= G100), V109 (= V101), D112 (= D104), T132 (= T124), T133 (= T125), L135 (= L127), D139 (= D131), S140 (= S132), K145 (= K137), K154 (= K146), T175 (= T167), L176 (= L168), P177 (= P169), E180 (= E172), H280 (= H259)
binding zinc ion: E187 (= E179), H264 (= H242), H280 (= H259)

Sites not aligning to the query:

binding (4S,5R)-4,5-dihydroxy-3-oxocyclohex-1-ene-1-carboxylic acid: 1060, 1062, 1181, 1224, 1232, 1242, 1243
binding nicotinamide-adenine-dinucleotide: 42, 44, 45
binding (3r,4s,5r)-3,4,5-trihydroxycyclohex-1-ene-1-carboxylic acid: 413, 562, 563, 874, 923, 924, 979, 1277, 1279, 1323, 1327, 1348, 1368, 1526

3qbeA Crystal structure of the 3-dehydroquinate synthase (arob) from mycobacterium tuberculosis
43% identity, 79% coverage: 50:329/354 of query aligns to 52:326/352 of 3qbeA

query
sites
3qbeA

E

K

R

R

L

L

A

A

V

G

P

K

G

G

A

V

E

D

V

A

Q

H

S

R

V

I

T

E

L

I

H

P

D

D

G

A

E

E

R

A

Y

G

K

K

T

D

L

L

Q

P

T

V

C

V

E

G

Q

F

V

I

Y

W

D

E

A

V

L

L

I

G

E

R

G

I

R

G

F

I

D

G

R

R

S

K

A

D

T

A

V

L

I

V

A

S

L

L

G

G

V

A

G

T

D

D

M

V

A

A

G

G

F

F

C

A

A

A

T

T

Y

W

Q

L

R
|
R

G

G

V

V

G

S

Y

I

I

V

Q

H

V

L

P

P

T

T

L

L

A

G

Q

M

V

V

D

D

S

A

V

V

G

G

K
|
K

T

T

G

G

V

I

N

N

H

T

P

D

R

A

G

G

K

K

N

N

M

L

I

V

G

G

A

A

F

F

H

H

Q

Q

P

P

R

L

A

A

V

V

V

L

A

V

D

D

T

L

G

A

V

T

L

L

A

Q

T

T

L

L

P

P

E

R

R

D

E

E

Y

M

N

I

A

C

G

G

L

M

A

A

E
|
E

V

V

K

K

Y

A

G

G

L

F

I

I

R

A

D

D

P

P

A

V

F

I

F

L

D

D

W

L

L

I

E

E

A

A

H

D

V

P

D

Q

A

A

L

A

R

L

R

D

R

P

D

A

P

G

E

D

A

V

L

L

A

P

H

E

A

L

V

I

A

R

E

R

S

A

C

I

R

T

N

V

K
|
K

A

A

E

E

V

V

A

A

D

S

E

E

R

L

E

-

A

-

G

-

E

-

R
|
R

A

E

L

I

L

L

N
|
N

L

Y

G

G

H
|
H

T

T

F

L

G

G

H
|
H

A

A

I

I

E

E

T

R

Y

R

T

E

D

R

Y

Y

C

-

T

R

W

W

L

R

H
|
H

G

G

E

A

A

A

V

V

A

S

A

V

G

G

M

L

V

V

M

F

A

A

R

E

M

L

S

A

V

R

R

L

L

A

G

G

W

R

L

L

Q

D

R

D

N

A

G

T

L

A

E

Q

R

R

T

H

I

R

A

T

L

I

L

L

E

S

A

S

F

L

G

G

L

L

P

P

T

V

R

S

-

Y

-

D

P

P

P

D

A

A

I

L

P

P

E

Q

A

-

R

-

F

L

R

L

E

E

L

I

M

M

S

A

V

G

D

D

K

K

N

T

R

R

G

A

G

G

Q

V

L

L

R

R

L

F

V

V

L

V

L

L

active site: R117 (= R115), K139 (= K137), E181 (= E179), K223 (= K221), R233 (= R235), N237 (= N239), H240 (= H242), H244 (= H246), H256 (= H259)
binding zinc ion: E181 (= E179), H240 (= H242), H256 (= H259)

6c5cA Crystal structure of the 3-dehydroquinate synthase (dhqs) domain of aro1 from candida albicans sc5314 in complex with nadh (see paper)
38% identity, 91% coverage: 15:335/354 of query aligns to 17:367/385 of 6c5cA

query
sites
6c5cA

I

I

Y

H

I

V

G

G

D

Y

G

G

V

I

L

A

D

D

Q

H

G

I

V

V

-

R

-

E

L

V

A

I

E

A

H

N

L

L

V

A

A

S

D

S

R

T

A

Y

L

V

L

I

V

V

S

T

N
x
D

E

T

T
x
N

V
x
M

A

A

-

R

-

T

P

P

L

Q

Y

Y

A

S

E

K

R

L

L

T

-

D

-

F

-

K

-

T

-

N

-

L

-

S

-

E

A

K

V

R

P

P

G

E

A

S

E

R

V

L

Q

L

S

T

V

Y

T

C

L

V

H

S

D

P

G

G

E
|
E

R

N

Y

N

K
|
K

T

N

L

R

Q

A

T

T

C

K

E

A

Q

A

V

V

Y

E

D

D

A

F

L

L

I

L

E

Q

G

Q

R

G

F

C

D

T

R

R

S

D

A

T

T

V

V

I

I

L

A

A

L

V

G

G

G
|
G

V
|
V

V

I

G

G

D
|
D

M

M

A

I

G

G

F

F

C

V

A

A

T

T

Y

F

Q

M

R
|
R

G

G

V

V

G

R

Y

V

I

V

Q

Q

V

V

P

P

T
|
T

L

L

A

A

Q

M

V

V

D
|
D

S
|
S

S

S

V

V

G

G

K
|
K

T

T

G

A

V

I

N

D

H

T

P

P

R

L

G

G

K

K

N

N

M

F

I

I

G

G

A

A

F

F

H

H

Q

Q

P

P

R

E

A

Y

V

V

V

F

A

C

D

D

T

V

G

S

V
x
F

L

L

A

E

T
|
T

L
|
L

P

P

E

A

R

R

E
x
Q

Y

F

N

I

A

N

G

G

L

M

A

A

E
|
E

V

V

K

K

Y

T

G

A

L

A

I

I

R

W

D

N

P

E

A

E

F

E

F

F

D

T

W

R

L

L

E

E

-

N

-

F

-

S

-

K

A

K

H

F

V

L

D

S

A

V

L

V

R

T

R

S

R

K

D

K

P

P

E

D

-

L

-

Q

-

S

-

I

-

K

-

A

A

E

L

L

A

V

H

K

A

T

V

V

A

L

E

E

S

S

C

V

R

R

N

V

K
|
K

A

A

E

G

V

V

A

S

D

D

E

-

R

-

E
|
E

A

A

G

G

E

L

R
|
R

A

N

L

L

N
|
N

L

F

G

G

H
|
H

T

T

F

I

G

G

H
|
H

A

A

I

I

E

E

T

A

Y

V

T

L

D

T

Y

P

C

-

T

E

W

A

L

L

H
|
H

G

G

E

E

A

C

V

V

A

S

A

I

G

G

M

M

V

I

M

K

A

E

A

A

R

E

M

L

S

S

V

R

R

Y

L

L

G

G

W

I

L

L

Q

P

R

P

N

V

G

A

L

V

E

A

R

R

T

L

I

S

A

K

L

C

L

L

E

V

A

A

F

Y

G

G

L

L

P

P

T

V

R

S

-

I

-

D

-

K

-

E

-

F

-

L

P

K

A

V

I

G

P

P

E

K

A

R

R

H

F

Y

R

V

E

E

L

I

-

D

-

I

-

L

-

K

M

M

S

A

V

I

D

D

K

K

N

N

R

-

G

-

Q

D

L

I

R

R

L

C

V

V

L

L

R

E

S

K

V

I

G

G

D

K

A

C

active site: R130 (= R115), K152 (= K137), E194 (= E179), K246 (= K221), E254 (= E231), R258 (= R235), N262 (= N239), H265 (= H242), H269 (= H246), H281 (= H259)
binding nicotinamide-adenine-dinucleotide: D45 (≠ N41), N47 (≠ T43), M48 (≠ V44), E83 (= E68), K86 (= K71), G114 (= G99), G115 (= G100), V116 (= V101), D119 (= D104), T139 (= T124), T140 (= T125), D146 (= D131), S147 (= S132), F179 (≠ V164), T182 (= T167), L183 (= L168), Q187 (≠ E172)

1xagA Crystal structure of staphlyococcus aureus 3-dehydroquinate synthase (dhqs) in complex with zn2+, NAD+ and carbaphosphonate (see paper)
36% identity, 92% coverage: 11:337/354 of query aligns to 10:334/353 of 1xagA

query
sites
1xagA

R

N

S

N

Y

Y

P

P

I

I

Y

Y

I

V

G

E

D

H

G

G

V

A

L

I

D

K

Q

Y

-

I

G

G

V

T

L

Y

A

L

E

N

H

Q

L

F

V

-

A

-

D

D

R

Q

A

S

L

F

L

L

V

L

S

I

N
x
D

E

E

T
x
Y

V
|
V

A

N

P

Q

L
x
Y

Y

F

A

A

E

N

R

K

L

F

-

D

A

I

V

L

P

S

G

Y

A

E

E

N

V

V

Q

H

S

K

V

V

T

I

L

I

H

P

D

A

G

G

E
|
E

R

K

Y

T

K
|
K

T

T

L

F

Q

E

T

Q

C

Y

E

Q

Q

E

V

T

Y

L

D

E

A

Y

L

I

I

L

E

S

G

H

R

H

F

V

D

T

R

R

S

N

A

T

T

A

V

I

I

I

A

A

L

V

G

G

G
|
G

V
x
A

V

T

G

G

D
|
D

M

F

A

A

G

G

F

F

C

V

A

A

T

T

Y

L

Q

L

R
|
R

G

G

V

V

G

H

Y

F

I

I

Q

Q

V

V

P

P

T
|
T

L

I

L
|
L

A

A

Q

H

V

-

D
|
D

S
|
S

S

S

V

V

G

G

K
|
K

T

V

G

G

V

I

N

N

H

S

P

K

R

Q

G

G

K
|
K

N
|
N

M

L

I

I

G

G

A

A

F

F

H

Y

Q

R

P

P

R

T

A

A

V

V

V

I

A

Y

D

D

T

L

G

D

V

F

L

L

A

K

T
|
T

L
|
L

P

P

E

F

R

K

E
x
Q

Y

I

N

L

A

S

G

G

L

Y

A

A

E
|
E

V

V

V

Y

K

K

Y

H

G

A

L

L

I

L

R

N

D

G

P

E

A

S

F

A

F

T

D

Q

W

D

L

I

E

E

A

Q

H

H

V

F

-

K

D

D

A

R

L

E

R

I

R

L

R

Q

D

S

P

L

E

N

A

G

L

M

A

D

H

K

A

Y

V

I

A

A

E

K

S

G

C

I

R

E

N

T

K
|
K

A

L

E

D

V

I

V

V

A

V

A

A

D

D

E

E

R

K

E
|
E

A

Q

G

G

E

V

R
|
R

A

K

L

F

L
|
L

N
|
N

L

L

G

G

H
|
H

T

T

F

F

G

G

H
|
H

A

A

I

V

E

E

T

Y

Y

-

T

-

D

-

Y

Y

C

H

T

K

W

I

L

P

H
|
H

G

G

E

H

A

A

V

V

A

M

A

V

G

G

M

I

V

I

M

Y

A

Q

A

F

R

I

M

V

S

A

V

N

R

A

L

L

G

-

W

F

L

D

Q

S

R

K

N

H

G

D

L

I

E

S

R

H

T

Y

I

I

A

Q

L

Y

L

L

E

I

A

Q

F

L

G

G

L

Y

P

P

T

L

R

-

P

-

P

D

A

M

I

I

P

T

E

D

A

L

R

D

F

F

R

E

E

T

L

L

-

Y

-

Q

-

Y

M

M

S

L

V

S

D

D

K
|
K

K

K

N

N

R

D

G

K

G

Q

Q

G

L

V

R

Q

L

M

V

V

L

L

L

M

R

R

S

Q

V

F

G

G

D

D

A

I

V

V

active site: R115 (= R115), K136 (= K137), E178 (= E179), K221 (= K221), E231 (= E231), R235 (= R235), N239 (= N239), H242 (= H242), H246 (= H246), H256 (= H259)
binding [1r-(1alpha,3beta,4alpha,5beta)]-5-(phosphonomethyl)-1,3,4-trihydroxycyclohexane-1-carboxylic acid: K136 (= K137), N146 (= N147), E178 (= E179), K221 (= K221), R235 (= R235), L238 (= L238), N239 (= N239), H242 (= H242), H246 (= H246), K314 (= K317)
binding nicotinamide-adenine-dinucleotide: D39 (≠ N41), Y41 (≠ T43), V42 (= V44), Y45 (≠ L47), E68 (= E68), K71 (= K71), G99 (= G99), G100 (= G100), A101 (≠ V101), D104 (= D104), T124 (= T124), T125 (= T125), L127 (= L127), D130 (= D131), S131 (= S132), K136 (= K137), K145 (= K146), T166 (= T167), L167 (= L168), Q171 (≠ E172), H256 (= H259)
binding zinc ion: E178 (= E179), H242 (= H242), H256 (= H259)

Q6GGU4 3-dehydroquinate synthase; DHQS; EC 4.2.3.4 from Staphylococcus aureus (strain MRSA252) (see paper)
36% identity, 92% coverage: 11:337/354 of query aligns to 10:334/354 of Q6GGU4

query
sites
Q6GGU4

R

N

S

N

Y

Y

P

P

I

I

Y

F

I

V

G

E

D

H

G

G

V

A

L

I

D

D

Q

H

G

-

V

-

L

I

A

S

E

T

H

Y

L

I

-

D

V

Q

A

F

D

D

R

Q

A

S

L

F

L

I

V

L

S

I

N
x
D

E

E

T

H

V

V

A

N

P

Q

L
x
Y

Y

F

A

A

E

D

R

K

L

F

-

N

-

D

A

I

V

L

P

S

G

Y

A

E

E

N

V

V

Q

H

S

K

V

V

T

I

L

I

H

P

D

A

G

G

E
|
E

R
x
K

Y
x
T

K
|
K

T

T

L

F

Q

E

T

Q

C

Y

E

Q

Q

E

V

T

Y

L

D

E

A

Y

L

I

I

L

E

S

G

H

R

H

F

V

D

T

R

R

S

N

A

T

T

A

V

I

I

I

A

A

L

V

G

G

G
|
G

V
x
A

V
x
T

G
|
G

D
|
D

M

F

A

A

G

G

F

F

C

V

A

A

T

T

Y

L

Q

L

R

R

G

G

V

V

G

H

Y

F

I

I

Q

Q

V

V

P

P

T
|
T

L

I

L

L

A

A

Q

H

V

-

D

D

S

S

V

V

G

G

K
|
K

T

V

G

G

V

I

N

N

H

S

P

K

R

Q

G

G

K
|
K

N

N

M

L

I

I

G

G

A

A

F

F

H

Y

Q

R

P

P

R

T

A

A

V

V

V

I

A

Y

D

D

T

L

G

D

V
x
F

L
|
L

A
x
K

T
|
T

L

L

P

P

E

F

R

E

E

Q

Y

I

N

L

A

S

G

G

L

Y

A

A

E
|
E

V

V

V

Y

K

K

Y

H

G

A

L

L

I

L

R

N

D

G

P

E

A

S

F

A

F

T

D

Q

W

D

L

I

E

E

A

Q

H

H

V

F

-

K

D

D

A

R

L

E

R

I

R

L

R

Q

D

S

P

L

E

K

A

G

L

M

A

D

H

K

A

Y

V

I

A

A

E

K

S

G

C

I

R

E

N

T

K

K

A

L

E

D

V

I

V

V

A

V

A

A

D

D

E

E

R

K

E

E

A

Q

G

G

E

V

R

R

A

K

L

F

L

L

N

N

L

L

G

G

H
|
H

T

T

F

F

G

G

H

H

A

A

I

V

E

E

T

Y

Y

-

T

-

D

-

Y

Y

C

H

T

K

W

I

L

P

H
|
H

G

G

E

H

A

A

V

V

A

M

A

V

G

G

M

I

V

I

M

Y

A

Q

A

F

R

I

M

V

S

A

V

N

R

A

L

L

G

-

W

F

L

D

Q

S

R

K

N

H

G

D

L

I

E

N

R

H

T

Y

I

I

A

Q

L

Y

L

L

E

I

A

Q

F

L

G

G

L

Y

P

P

T

L

R

-

P

-

P

D

A

M

I

I

P

T

E

D

A

L

R

D

F

F

R

E

E

T

L

L

-

Y

-

Q

-

Y

M

M

S

L

V

S

D

D

K

K

N

N

R

D

G

K

G

Q

Q

G

L

V

R

Q

L

M

V

V

L

L

L

I

R

R

S

Q

V

F

G

G

D

D

A

I

V

V

D39 (≠ N41) binding NAD(+)
Y45 (≠ L47) binding NAD(+)
EKTK 68:71 (≠ ERYK 68:71) binding NAD(+)
GATGD 100:104 (≠ GVVGD 100:104) binding NAD(+)
TT 124:125 (= TT 124:125) binding NAD(+)
K136 (= K137) binding NAD(+)
K145 (= K146) binding NAD(+)
FLKT 163:166 (≠ VLAT 164:167) binding NAD(+)
E178 (= E179) binding Zn(2+)
H242 (= H242) binding Zn(2+)
H256 (= H259) binding Zn(2+)

Query Sequence

>WP_011815043.1 NCBI__GCF_000015585.1:WP_011815043.1
MRTQWVELGERSYPIYIGDGVLDQGVLAEHLVADRALLVSNETVAPLYAERLAVPGAEVQ
SVTLHDGERYKTLQTCEQVYDALIEGRFDRSATVIALGGGVVGDMAGFCAATYQRGVGYI
QVPTTLLAQVDSSVGGKTGVNHPRGKNMIGAFHQPRAVVADTGVLATLPEREYNAGLAEV
VKYGLIRDPAFFDWLEAHVDALRRRDPEALAHAVAESCRNKAEVVAADEREAGERALLNL
GHTFGHAIETYTDYCTWLHGEAVAAGMVMAARMSVRLGWLQRNGLERTIALLEAFGLPTR
PPAIPEARFRELMSVDKKNRGGQLRLVLLRSVGDAVVTGEFAPEALTDTLVEAV

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory