SitesBLAST
Comparing WP_011815134.1 NCBI__GCF_000015585.1:WP_011815134.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
4whxA X-ray crystal structure of an amino acid aminotransferase from burkholderia pseudomallei bound to the co-factor pyridoxal phosphate
65% identity, 100% coverage: 2:306/306 of query aligns to 1:306/306 of 4whxA
2ej0B Crystal structure of t.Th.Hb8 branched-chain amino acid aminotransferase with pyridoxamine 5'-phosphate
52% identity, 98% coverage: 6:306/306 of query aligns to 3:304/305 of 2ej0B
- active site: F35 (= F38), G37 (= G40), K158 (= K160), E192 (= E194), L215 (= L217)
- binding 4'-deoxy-4'-aminopyridoxal-5'-phosphate: R58 (= R61), Y163 (= Y165), E192 (= E194), G195 (= G197), E196 (= E198), L215 (= L217), G217 (= G219), I218 (= I220), T219 (= T221), G254 (= G256), T255 (= T257)
2ej2A Crystal structure of t.Th.Hb8 branched-chain amino acid aminotransferase complexed with n-(5'-phosphopyridoxyl)-l-glutamate
50% identity, 98% coverage: 6:306/306 of query aligns to 3:293/294 of 2ej2A
- active site: F35 (= F38), G37 (= G40), K147 (= K160), E181 (= E194), L204 (= L217)
- binding 4-[(1,3-dicarboxy-propylamino)-methyl]-3-hydroxy-2-methyl-5-phosphonooxymethyl-pyridinium: R58 (= R61), Y94 (= Y97), Y152 (= Y165), E181 (= E194), G184 (= G197), E185 (= E198), L204 (= L217), G206 (= G219), I207 (= I220), T208 (= T221), T244 (= T257), A245 (= A258)
2ej3A Crystal structure of t.Th.Hb8 branched-chain amino acid aminotransferase complexed with gabapentin
50% identity, 98% coverage: 6:306/306 of query aligns to 3:296/297 of 2ej3A
- active site: F35 (= F38), G37 (= G40), K150 (= K160), E184 (= E194), L207 (= L217)
- binding [1-(aminomethyl)cyclohexyl]acetic acid: G187 (= G197), G246 (= G256), T247 (= T257), A248 (= A258)
- binding pyridoxal-5'-phosphate: R58 (= R61), K150 (= K160), Y155 (= Y165), E184 (= E194), G187 (= G197), L207 (= L217), G209 (= G219), I210 (= I220), T211 (= T221), G246 (= G256), T247 (= T257)
2eiyA Crystal structure of t.Th.Hb8 branched-chain amino acid aminotransferase complexed with 4-methylvaleric acid
50% identity, 98% coverage: 6:306/306 of query aligns to 3:296/297 of 2eiyA
- active site: F35 (= F38), G37 (= G40), K150 (= K160), E184 (= E194), L207 (= L217)
- binding 4-methyl valeric acid: F35 (= F38), Y94 (= Y97), T247 (= T257), A248 (= A258)
- binding pyridoxal-5'-phosphate: R58 (= R61), K150 (= K160), Y155 (= Y165), E184 (= E194), G187 (= G197), E188 (= E198), L207 (= L217), G209 (= G219), I210 (= I220), T211 (= T221), G246 (= G256), T247 (= T257)
1wrvA Crystal structure of t.Th.Hb8 branched-chain amino acid aminotransferase
50% identity, 98% coverage: 6:306/306 of query aligns to 3:296/297 of 1wrvA
- active site: F35 (= F38), G37 (= G40), K150 (= K160), E184 (= E194), L207 (= L217)
- binding pyridoxal-5'-phosphate: R58 (= R61), K150 (= K160), Y155 (= Y165), E184 (= E194), G187 (= G197), L207 (= L217), G209 (= G219), I210 (= I220), T211 (= T221), T247 (= T257)
1iyeA Crystal structure of eschelichia coli branched-chain amino acid aminotransferase (see paper)
49% identity, 97% coverage: 9:306/306 of query aligns to 4:303/304 of 1iyeA
- active site: F33 (= F38), G35 (= G40), K156 (= K160), A157 (= A161), E190 (= E194), L214 (= L217)
- binding N-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)-L-glutamic acid: R56 (= R61), Y92 (= Y97), Y126 (= Y130), K156 (= K160), Y161 (= Y165), E190 (= E194), G193 (= G197), E194 (= E198), N195 (= N199), L214 (= L217), G216 (= G219), I217 (= I220), T218 (= T221), G253 (= G256), T254 (= T257), A255 (= A258)
1iydA Crystal structure of eschelichia coli branched-chain amino acid aminotransferase (see paper)
49% identity, 97% coverage: 9:306/306 of query aligns to 4:303/304 of 1iydA
- active site: F33 (= F38), G35 (= G40), K156 (= K160), A157 (= A161), E190 (= E194), L214 (= L217)
- binding glutaric acid: Y92 (= Y97), Y126 (= Y130), A255 (= A258)
- binding pyridoxal-5'-phosphate: R56 (= R61), K156 (= K160), Y161 (= Y165), E190 (= E194), G193 (= G197), E194 (= E198), L214 (= L217), G216 (= G219), I217 (= I220), T218 (= T221), T254 (= T257)
1i1mA Crystal structure of escherichia coli branched-chain amino acid aminotransferase. (see paper)
49% identity, 97% coverage: 9:306/306 of query aligns to 4:303/304 of 1i1mA
- active site: K156 (= K160)
- binding 4-methyl valeric acid: Y92 (= Y97), K156 (= K160), T254 (= T257), A255 (= A258)
- binding pyridoxal-5'-phosphate: R56 (= R61), K156 (= K160), Y161 (= Y165), E190 (= E194), G193 (= G197), E194 (= E198), L214 (= L217), G216 (= G219), I217 (= I220), T218 (= T221), G253 (= G256), T254 (= T257)
1i1lA Crystal structure of eschelichia coli branched-chain amino acid aminotransferase. (see paper)
49% identity, 97% coverage: 9:306/306 of query aligns to 4:303/304 of 1i1lA
- active site: K156 (= K160)
- binding 2-methylleucine: Y92 (= Y97), K156 (= K160), T254 (= T257), A255 (= A258)
- binding pyridoxal-5'-phosphate: R56 (= R61), K156 (= K160), Y161 (= Y165), E190 (= E194), G193 (= G197), G216 (= G219), I217 (= I220), T218 (= T221), T254 (= T257)
6thqB Crystal structure of branched-chain aminotransferase from thermophilic archaea thermoproteus uzoniensis with norvaline
44% identity, 97% coverage: 10:306/306 of query aligns to 9:300/301 of 6thqB
- active site: F37 (= F38), K156 (= K160), E190 (= E194), L214 (= L217)
- binding pyridoxal-5'-phosphate: R60 (= R61), K156 (= K160), Y161 (= Y165), E190 (= E194), N195 (= N199), L214 (= L217), G216 (= G219), I217 (= I220), T218 (= T221), T254 (= T257)
- binding 2-[o-phosphonopyridoxyl]-amino-pentanoic acid: R60 (= R61), Y97 (= Y97), K156 (= K160), Y161 (= Y165), E190 (= E194), G193 (= G197), E194 (= E198), N195 (= N199), G216 (= G219), I217 (= I220), T218 (= T221), G253 (= G256), T254 (= T257), A255 (= A258)
5mr0D Thermophilic archaeal branched-chain amino acid transaminases from geoglobus acetivorans and archaeoglobus fulgidus: biochemical and structural characterisation (see paper)
39% identity, 93% coverage: 9:293/306 of query aligns to 3:282/290 of 5mr0D
- active site: F32 (= F38), G34 (= G40), K150 (≠ A161), E183 (= E194), L206 (= L217)
- binding 3-[o-phosphonopyridoxyl]--amino-benzoic acid: R51 (= R61), G100 (= G110), L101 (= L111), K150 (≠ A161), Y154 (= Y165), E183 (= E194), G186 (= G197), D187 (≠ E198), L206 (= L217), I209 (= I220), T210 (= T221), G245 (= G256), T246 (= T257)
5e25A Crystal structure of branched-chain aminotransferase from thermophilic archaea geoglobus acetivorans complexed with alpha-ketoglutarate (see paper)
38% identity, 91% coverage: 10:288/306 of query aligns to 5:278/290 of 5e25A
- active site: F33 (= F38), G35 (= G40), K151 (= K160), E184 (= E194), L207 (= L217)
- binding 2-oxoglutaric acid: Y88 (= Y97), K151 (= K160), T247 (= T257), A248 (= A258)
- binding pyridoxal-5'-phosphate: R52 (= R61), K151 (= K160), Y155 (= Y165), E184 (= E194), G187 (= G197), D188 (≠ E198), L207 (= L217), G209 (= G219), I210 (= I220), T211 (= T221), G246 (= G256), T247 (= T257)
6q8eA Crystal structure of branched-chain amino acid aminotransferase from thermobaculum terrenum in pmp-form (see paper)
41% identity, 97% coverage: 9:306/306 of query aligns to 5:304/307 of 6q8eA
- active site: F34 (= F38), K156 (= K160), E190 (= E194), L214 (= L217)
- binding 4'-deoxy-4'-aminopyridoxal-5'-phosphate: R59 (= R61), K156 (= K160), Y161 (= Y165), E190 (= E194), G193 (= G197), S194 (≠ E198), C195 (≠ N199), L214 (= L217), S216 (≠ G219), I217 (= I220), T218 (= T221), G254 (= G256), T255 (= T257)
7neaA Crystal structure of branched-chain amino acid aminotransferase from thermobaculum terrenum (m3 mutant). (see paper)
40% identity, 97% coverage: 9:306/306 of query aligns to 5:304/309 of 7neaA
- active site: F34 (= F38), K156 (= K160), E190 (= E194), L214 (= L217)
- binding pyridoxal-5'-phosphate: R59 (= R61), K156 (= K160), Y161 (= Y165), E190 (= E194), G193 (= G197), S194 (≠ E198), L214 (= L217), S216 (≠ G219), I217 (= I220), T218 (= T221), T255 (= T257)
6h65C Crystal structure of the branched-chain-amino-acid aminotransferase from haliangium ochraceum
34% identity, 97% coverage: 9:306/306 of query aligns to 6:306/308 of 6h65C
- active site: F35 (= F38), K158 (= K160), E192 (= E194), L216 (= L217)
- binding pyridoxal-5'-phosphate: R60 (= R61), K158 (= K160), Y163 (= Y165), E192 (= E194), A196 (≠ E198), L216 (= L217), S218 (≠ G219), V219 (≠ I220), T220 (= T221), G256 (= G256), T257 (= T257)
7p3tB Transaminase of gamma-proteobacterium (see paper)
36% identity, 93% coverage: 10:293/306 of query aligns to 6:284/299 of 7p3tB
- binding pyridoxal-5'-phosphate: R53 (= R61), K153 (= K160), R157 (≠ Y165), E186 (= E194), S187 (≠ G195), A188 (≠ S196), A189 (≠ G197), S190 (≠ E198), G210 (= G219), I211 (= I220), T212 (= T221), T248 (= T257)
7z79B Crystal structure of aminotransferase-like protein from variovorax paradoxus
33% identity, 95% coverage: 10:299/306 of query aligns to 18:302/306 of 7z79B
- binding pyridoxal-5'-phosphate: W46 (≠ F38), R65 (= R61), N166 (≠ K160), S202 (≠ G197), T203 (≠ E198), F222 (≠ L217), G224 (= G219), I225 (= I220), T226 (= T221), G261 (= G256), T262 (= T257)
6xwbA Crystal structure of an r-selective transaminase from thermomyces stellatus. (see paper)
28% identity, 96% coverage: 7:300/306 of query aligns to 27:314/319 of 6xwbA
- binding pyridoxal-5'-phosphate: R77 (= R61), K178 (≠ A161), F185 (≠ S168), E211 (= E194), G214 (= G197), F215 (≠ E198), N216 (= N199), L233 (= L217), G235 (= G219), V236 (≠ I220), T237 (= T221), T273 (= T257)
3lqsA Complex structure of d-amino acid aminotransferase and 4-amino-4,5- dihydro-thiophenecarboxylic acid (adta) (see paper)
30% identity, 92% coverage: 8:288/306 of query aligns to 1:272/280 of 3lqsA
- active site: Y31 (≠ F38), V33 (≠ G40), K145 (= K160), E177 (= E194), L201 (= L217)
- binding 4-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)amino]thiophene-2-carboxylic acid: V33 (≠ G40), R50 (= R61), E177 (= E194), S180 (≠ G197), S181 (≠ E198), N182 (= N199), L201 (= L217), G203 (= G219), I204 (= I220), T205 (= T221), S240 (≠ G256), T241 (= T257), T242 (≠ A258)
Query Sequence
>WP_011815134.1 NCBI__GCF_000015585.1:WP_011815134.1
MSFADRDGYIWLDGEMLPWREARVHCLTHTLHYGMGVFEGLRAYTTEHGPAIFRLEEHTR
RLFNSAKILGMEIAHSPEAINQACIDAVRRNGLSSAYIRPMSFYGSEGMGLHADGLRTHT
MVAAWHWGAYLGDESRERGIRVQTSSFTRHHVNIAMCRAKANGNYMNSMLAVQEATRAGC
DEALLLDVDGFVCEGSGENFFMVRDGVLHTPALTSALEGITRDTVMRLAAEEGIEVRERR
ITRDEVYIADEAFFTGTAAEVTPIRELDGRTIGPGHRGPITERLQSRYFNLVEGRDPSHT
DWLTFV
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory