SitesBLAST
Comparing WP_011840341.1 NCBI__GCF_000015985.1:WP_011840341.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
P19938 D-alanine aminotransferase; D-amino acid aminotransferase; D-amino acid transaminase; DAAT; D-aspartate aminotransferase; EC 2.6.1.21 from Bacillus sp. (strain YM-1) (see 5 papers)
36% identity, 97% coverage: 1:277/286 of query aligns to 1:273/283 of P19938
- M1 (= M1) modified: Initiator methionine, Removed
- Y32 (= Y33) binding substrate
- R51 (= R52) binding pyridoxal 5'-phosphate
- R99 (= R101) binding substrate
- H101 (≠ F103) binding substrate
- K146 (= K150) active site, Proton acceptor; modified: N6-(pyridoxal phosphate)lysine
- E178 (= E182) binding pyridoxal 5'-phosphate; mutation to K: Loss of transaminase activity and small gain in racemase activity.
- L202 (= L206) mutation to A: Inactivates enzyme.
3daaA Crystallographic structure of d-amino acid aminotransferase inactivated by pyridoxyl-d-alanine (see paper)
36% identity, 94% coverage: 8:277/286 of query aligns to 6:272/277 of 3daaA
- active site: Y31 (= Y33), V33 (= V35), K145 (= K150), E177 (= E182), L201 (= L206)
- binding n-(5'-phosphopyridoxyl)-d-alanine: Y31 (= Y33), R50 (= R52), K145 (= K150), E177 (= E182), S180 (= S185), S181 (≠ N186), L201 (= L206), G203 (= G208), I204 (= I209), T205 (= T210), S240 (= S245), T241 (≠ A246)
2daaA Crystallographic structure of d-amino acid aminotransferase inactivated by d-cycloserine
36% identity, 94% coverage: 8:277/286 of query aligns to 6:272/277 of 2daaA
- active site: Y31 (= Y33), V33 (= V35), K145 (= K150), E177 (= E182), L201 (= L206)
- binding d-[3-hydroxy-2-methyl-5-phosphonooxymethyl-pyridin-4-ylmethyl]-n,o-cycloserylamide: Y31 (= Y33), V33 (= V35), R50 (= R52), R98 (= R101), H100 (≠ F103), K145 (= K150), E177 (= E182), S180 (= S185), S181 (≠ N186), N182 (= N187), L201 (= L206), G203 (= G208), I204 (= I209), T205 (= T210), T241 (≠ A246)
1daaA Crystallographic structure of d-amino acid aminotransferase complexed with pyridoxal-5'-phosphate (see paper)
36% identity, 94% coverage: 8:277/286 of query aligns to 6:272/277 of 1daaA
- active site: Y31 (= Y33), V33 (= V35), K145 (= K150), E177 (= E182), L201 (= L206)
- binding pyridoxal-5'-phosphate: R50 (= R52), K145 (= K150), E177 (= E182), S180 (= S185), S181 (≠ N186), L201 (= L206), G203 (= G208), I204 (= I209), T205 (= T210), S240 (= S245), T241 (≠ A246)
3lqsA Complex structure of d-amino acid aminotransferase and 4-amino-4,5- dihydro-thiophenecarboxylic acid (adta) (see paper)
36% identity, 94% coverage: 8:277/286 of query aligns to 6:272/280 of 3lqsA
- active site: Y31 (= Y33), V33 (= V35), K145 (= K150), E177 (= E182), L201 (= L206)
- binding 4-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)amino]thiophene-2-carboxylic acid: V33 (= V35), R50 (= R52), E177 (= E182), S180 (= S185), S181 (≠ N186), N182 (= N187), L201 (= L206), G203 (= G208), I204 (= I209), T205 (= T210), S240 (= S245), T241 (≠ A246), T242 (≠ S247)
1a0gB L201a mutant of d-amino acid aminotransferase complexed with pyridoxamine-5'-phosphate (see paper)
36% identity, 94% coverage: 8:277/286 of query aligns to 6:272/282 of 1a0gB
- active site: Y31 (= Y33), V33 (= V35), K145 (= K150), E177 (= E182), A201 (≠ L206)
- binding 4'-deoxy-4'-aminopyridoxal-5'-phosphate: R50 (= R52), K145 (= K150), E177 (= E182), S180 (= S185), S181 (≠ N186), G203 (= G208), I204 (= I209), T205 (= T210), S240 (= S245), T241 (≠ A246)
5e25A Crystal structure of branched-chain aminotransferase from thermophilic archaea geoglobus acetivorans complexed with alpha-ketoglutarate (see paper)
34% identity, 95% coverage: 5:277/286 of query aligns to 5:278/290 of 5e25A
- active site: F33 (≠ Y33), G35 (≠ V35), K151 (= K150), E184 (= E182), L207 (= L206)
- binding 2-oxoglutaric acid: Y88 (≠ L88), K151 (= K150), T247 (≠ A246), A248 (≠ S247)
- binding pyridoxal-5'-phosphate: R52 (= R52), K151 (= K150), Y155 (≠ L154), E184 (= E182), G187 (≠ S185), D188 (≠ N186), L207 (= L206), G209 (= G208), I210 (= I209), T211 (= T210), G246 (≠ S245), T247 (≠ A246)
5mr0D Thermophilic archaeal branched-chain amino acid transaminases from geoglobus acetivorans and archaeoglobus fulgidus: biochemical and structural characterisation (see paper)
32% identity, 95% coverage: 5:275/286 of query aligns to 4:275/290 of 5mr0D
- active site: F32 (≠ Y33), G34 (≠ V35), K150 (= K150), E183 (= E182), L206 (= L206)
- binding 3-[o-phosphonopyridoxyl]--amino-benzoic acid: R51 (= R52), G100 (≠ D102), L101 (≠ F103), K150 (= K150), Y154 (≠ L154), E183 (= E182), G186 (≠ S185), D187 (≠ N186), L206 (= L206), I209 (= I209), T210 (= T210), G245 (≠ S245), T246 (≠ A246)
7p3tB Transaminase of gamma-proteobacterium (see paper)
32% identity, 95% coverage: 5:277/286 of query aligns to 6:279/299 of 7p3tB
- binding pyridoxal-5'-phosphate: R53 (= R52), K153 (= K150), R157 (≠ L154), E186 (= E182), S187 (≠ G183), A188 (≠ T184), A189 (≠ S185), S190 (≠ N186), G210 (= G208), I211 (= I209), T212 (= T210), T248 (≠ A246)
7z79B Crystal structure of aminotransferase-like protein from variovorax paradoxus
33% identity, 95% coverage: 5:277/286 of query aligns to 18:291/306 of 7z79B
- binding pyridoxal-5'-phosphate: W46 (≠ Y33), R65 (= R52), N166 (≠ L155), S202 (= S185), T203 (≠ N186), F222 (≠ L206), G224 (= G208), I225 (= I209), T226 (= T210), G261 (≠ S245), T262 (≠ A246)
2ej3A Crystal structure of t.Th.Hb8 branched-chain amino acid aminotransferase complexed with gabapentin
31% identity, 96% coverage: 5:279/286 of query aligns to 7:280/297 of 2ej3A
- active site: F35 (≠ Y33), G37 (vs. gap), K150 (vs. gap), E184 (= E182), L207 (= L206)
- binding [1-(aminomethyl)cyclohexyl]acetic acid: G187 (≠ S185), G246 (≠ S245), T247 (≠ A246), A248 (≠ S247)
- binding pyridoxal-5'-phosphate: R58 (= R52), K150 (vs. gap), Y155 (≠ L154), E184 (= E182), G187 (≠ S185), L207 (= L206), G209 (= G208), I210 (= I209), T211 (= T210), G246 (≠ S245), T247 (≠ A246)
2eiyA Crystal structure of t.Th.Hb8 branched-chain amino acid aminotransferase complexed with 4-methylvaleric acid
31% identity, 96% coverage: 5:279/286 of query aligns to 7:280/297 of 2eiyA
- active site: F35 (≠ Y33), G37 (vs. gap), K150 (vs. gap), E184 (= E182), L207 (= L206)
- binding 4-methyl valeric acid: F35 (≠ Y33), Y94 (≠ L88), T247 (≠ A246), A248 (≠ S247)
- binding pyridoxal-5'-phosphate: R58 (= R52), K150 (vs. gap), Y155 (≠ L154), E184 (= E182), G187 (≠ S185), E188 (≠ N186), L207 (= L206), G209 (= G208), I210 (= I209), T211 (= T210), G246 (≠ S245), T247 (≠ A246)
1wrvA Crystal structure of t.Th.Hb8 branched-chain amino acid aminotransferase
31% identity, 96% coverage: 5:279/286 of query aligns to 7:280/297 of 1wrvA
- active site: F35 (≠ Y33), G37 (vs. gap), K150 (vs. gap), E184 (= E182), L207 (= L206)
- binding pyridoxal-5'-phosphate: R58 (= R52), K150 (vs. gap), Y155 (≠ L154), E184 (= E182), G187 (≠ S185), L207 (= L206), G209 (= G208), I210 (= I209), T211 (= T210), T247 (≠ A246)
2ej0B Crystal structure of t.Th.Hb8 branched-chain amino acid aminotransferase with pyridoxamine 5'-phosphate
30% identity, 96% coverage: 5:279/286 of query aligns to 7:288/305 of 2ej0B
- active site: F35 (≠ Y33), G37 (vs. gap), K158 (vs. gap), E192 (= E182), L215 (= L206)
- binding 4'-deoxy-4'-aminopyridoxal-5'-phosphate: R58 (= R52), Y163 (≠ L154), E192 (= E182), G195 (≠ S185), E196 (≠ N186), L215 (= L206), G217 (= G208), I218 (= I209), T219 (= T210), G254 (≠ S245), T255 (≠ A246)
2ej2A Crystal structure of t.Th.Hb8 branched-chain amino acid aminotransferase complexed with n-(5'-phosphopyridoxyl)-l-glutamate
31% identity, 96% coverage: 5:279/286 of query aligns to 7:277/294 of 2ej2A
- active site: F35 (≠ Y33), G37 (vs. gap), K147 (≠ D148), E181 (= E182), L204 (= L206)
- binding 4-[(1,3-dicarboxy-propylamino)-methyl]-3-hydroxy-2-methyl-5-phosphonooxymethyl-pyridinium: R58 (= R52), Y94 (≠ L88), Y152 (≠ L154), E181 (= E182), G184 (≠ S185), E185 (≠ N186), L204 (= L206), G206 (= G208), I207 (= I209), T208 (= T210), T244 (≠ A246), A245 (≠ S247)
4ce5B First crystal structure of an (r)-selective omega-transaminase from aspergillus terreus (see paper)
28% identity, 98% coverage: 6:285/286 of query aligns to 33:314/325 of 4ce5B
- active site: Y60 (= Y33), K180 (≠ V152), E213 (= E182), L235 (= L206)
- binding calcium ion: D67 (≠ G40), R69 (≠ K42)
- binding n-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)-d-glutamic acid: V62 (= V35), R79 (= R52), K180 (≠ V152), W184 (≠ Y156), E213 (= E182), G216 (≠ S185), F217 (≠ N186), N218 (= N187), L235 (= L206), G237 (= G208), V238 (≠ I209), T239 (= T210), T274 (≠ S245), T275 (≠ A246), A276 (≠ S247)
- binding pyridoxal-5'-phosphate: R79 (= R52), K180 (≠ V152), E213 (= E182), G216 (≠ S185), F217 (≠ N186), L235 (= L206), G237 (= G208), V238 (≠ I209), T239 (= T210), T275 (≠ A246)
4ce5A First crystal structure of an (r)-selective omega-transaminase from aspergillus terreus (see paper)
28% identity, 98% coverage: 6:285/286 of query aligns to 33:314/325 of 4ce5A
- active site: Y60 (= Y33), K180 (≠ V152), E213 (= E182), L235 (= L206)
- binding n-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)-d-glutamic acid: Y60 (= Y33), V62 (= V35), R79 (= R52), K180 (≠ V152), W184 (≠ Y156), E213 (= E182), G216 (≠ S185), F217 (≠ N186), N218 (= N187), L235 (= L206), G237 (= G208), V238 (≠ I209), T239 (= T210), T274 (≠ S245), T275 (≠ A246)
- binding pyridoxal-5'-phosphate: R79 (= R52), K180 (≠ V152), E213 (= E182), F217 (≠ N186), L235 (= L206), G237 (= G208), V238 (≠ I209), T239 (= T210), T275 (≠ A246)
8ivpB Crystal structure of mv in complex with llp and fru from mycobacterium vanbaalenii
31% identity, 94% coverage: 6:275/286 of query aligns to 32:304/322 of 8ivpB
6snlD (R)-selective amine transaminase from exophiala sideris (see paper)
27% identity, 95% coverage: 6:277/286 of query aligns to 30:304/320 of 6snlD
- active site: Y57 (= Y33), K178 (≠ V152), E211 (= E182), L233 (= L206)
- binding pyridoxal-5'-phosphate: R76 (= R52), K178 (≠ V152), E211 (= E182), G214 (≠ S185), F215 (≠ N186), L233 (= L206), G235 (= G208), V236 (≠ I209), T237 (= T210), T273 (≠ A246)
7neaA Crystal structure of branched-chain amino acid aminotransferase from thermobaculum terrenum (m3 mutant). (see paper)
29% identity, 96% coverage: 3:277/286 of query aligns to 4:286/309 of 7neaA
- active site: F34 (≠ Y33), K156 (≠ R143), E190 (= E182), L214 (= L206)
- binding pyridoxal-5'-phosphate: R59 (= R52), K156 (≠ R143), Y161 (≠ I149), E190 (= E182), G193 (≠ S185), S194 (≠ N186), L214 (= L206), S216 (≠ G208), I217 (= I209), T218 (= T210), T255 (≠ A246)
Query Sequence
>WP_011840341.1 NCBI__GCF_000015985.1:WP_011840341.1
MSRTVYVNGEYLPEEEATVSIFDRGFLMADGVYEVTSVLGGKLIDFPGHAARLDRSLTEL
EMTAPMNAEDLLEVHRELVRRNGIDEGLIYLQITRGNPGDRDFAFPPADTKPTVVLFTQA
KPGLAANPTARVGIKVISIPDIRWGRRDIKTVQLLYPSMAKMAAKKAHVDDAWFVEDGLV
TEGTSNNAYIVKGGKIITRNLSNDILHGITRAAVVRFAREAQMEVEERPFTIEEAQGADE
AFFTSASAFVMPVVEIDGKAVGTGAPGPVAARLREIYLDESLKAAV
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory