SitesBLAST
Comparing WP_011842150.1 NCBI__GCF_000015985.1:WP_011842150.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
5iuwA Crystal structure of indole-3-acetaldehyde dehydrogenase in complexed with NAD+ and iaa (see paper)
58% identity, 99% coverage: 2:493/495 of query aligns to 2:493/495 of 5iuwA
- active site: N166 (= N166), K189 (= K189), E265 (= E265), C300 (= C300), E399 (= E399), D476 (= D476)
- binding 1h-indol-3-ylacetic acid: F167 (≠ Y167), M170 (≠ S170), C300 (= C300), D457 (= D457), F465 (= F465)
- binding nicotinamide-adenine-dinucleotide: I162 (≠ V162), V163 (= V163), P164 (= P164), W165 (= W165), N166 (= N166), K189 (= K189), G222 (= G222), G226 (= G226), K227 (= K227), F240 (= F240), T241 (= T241), G242 (= G242), S243 (= S243), I246 (≠ V246), Y253 (= Y253), E265 (= E265), A266 (≠ L266), C300 (= C300), E399 (= E399), F401 (= F401)
5iuvA Crystal structure of indole-3-acetaldehyde dehydrogenase in complexed with NAD+ (see paper)
58% identity, 99% coverage: 2:493/495 of query aligns to 2:493/495 of 5iuvA
- active site: N166 (= N166), K189 (= K189), E265 (= E265), C300 (= C300), E399 (= E399), D476 (= D476)
- binding nicotinamide-adenine-dinucleotide: I162 (≠ V162), V163 (= V163), P164 (= P164), W165 (= W165), N166 (= N166), K189 (= K189), S191 (≠ A191), G222 (= G222), G226 (= G226), K227 (= K227), F240 (= F240), T241 (= T241), G242 (= G242), S243 (= S243), I246 (≠ V246), Y253 (= Y253), E265 (= E265), A266 (≠ L266), C300 (= C300), E399 (= E399), F401 (= F401)
7jsoA P. Syringae alda indole-3-acetaldehyde dehydrogenase c302a mutant in complex with NAD+ and iaa (see paper)
58% identity, 99% coverage: 2:493/495 of query aligns to 2:493/495 of 7jsoA
- active site: N166 (= N166), E265 (= E265), A300 (≠ C300), D476 (= D476)
- binding 1h-indol-3-ylacetic acid: F167 (≠ Y167), W174 (= W174), V299 (= V299), A300 (≠ C300), T301 (≠ N301), D457 (= D457), F465 (= F465)
- binding 1,4-dihydronicotinamide adenine dinucleotide: I162 (≠ V162), V163 (= V163), P164 (= P164), W165 (= W165), K189 (= K189), E192 (= E192), G222 (= G222), G226 (= G226), K227 (= K227), F240 (= F240), G242 (= G242), S243 (= S243), I246 (≠ V246), A266 (≠ L266), G267 (= G267), A300 (≠ C300), E399 (= E399), F401 (= F401)
7uyyA The crystal structure of the pseudomonas aeruginosa aldehyde dehydrogenase encoded by the pa4189 gene in complex with nadh (see paper)
47% identity, 100% coverage: 1:493/495 of query aligns to 4:493/496 of 7uyyA
- binding 1,4-dihydronicotinamide adenine dinucleotide: V165 (= V162), L166 (≠ V163), P167 (= P164), W168 (= W165), K192 (= K189), G225 (= G222), G229 (= G226), F243 (= F240), G245 (= G242), S246 (= S243), T249 (≠ V246), L252 (≠ Y249), F253 (= F250), Y256 (= Y253), C269 (≠ L266), G270 (= G267), C303 (= C300), H350 (≠ Q347), K353 (≠ R350), F400 (= F401)
4pxlA Structure of zm aldh2-3 (rf2c) in complex with NAD (see paper)
46% identity, 95% coverage: 21:491/495 of query aligns to 9:476/486 of 4pxlA
- active site: N154 (= N166), K177 (= K189), E253 (= E265), C287 (= C300), E384 (= E399), D461 (= D476)
- binding nicotinamide-adenine-dinucleotide: I150 (≠ V162), V151 (= V163), P152 (= P164), W153 (= W165), K177 (= K189), E180 (= E192), G210 (= G222), G214 (= G226), A215 (≠ K227), F228 (= F240), G230 (= G242), S231 (= S243), V234 (= V246), E253 (= E265), G255 (= G267), C287 (= C300), Q334 (= Q347), K337 (≠ R350), E384 (= E399), F386 (= F401)
4pz2B Structure of zm aldh2-6 (rf2f) in complex with NAD (see paper)
46% identity, 95% coverage: 21:491/495 of query aligns to 14:484/494 of 4pz2B
- active site: N159 (= N166), K182 (= K189), E258 (= E265), C292 (= C300), E392 (= E399), D469 (= D476)
- binding nicotinamide-adenine-dinucleotide: I155 (≠ V162), I156 (≠ V163), P157 (= P164), W158 (= W165), N159 (= N166), M164 (= M171), K182 (= K189), A184 (= A191), E185 (= E192), G215 (= G222), G219 (= G226), F233 (= F240), T234 (= T241), G235 (= G242), S236 (= S243), V239 (= V246), E258 (= E265), L259 (= L266), C292 (= C300), E392 (= E399), F394 (= F401)
5l13A Structure of aldh2 in complex with 2p3 (see paper)
44% identity, 96% coverage: 18:491/495 of query aligns to 14:485/494 of 5l13A
- active site: N163 (= N166), K186 (= K189), E262 (= E265), C296 (= C300), E393 (= E399), E470 (≠ D476)
- binding 2,3,5-trimethyl-6-propyl-7H-furo[3,2-g][1]benzopyran-7-one: F164 (≠ Y167), M168 (= M171), W171 (= W174), F290 (≠ A294), C295 (≠ V299), C296 (= C300), C297 (≠ N301), D451 (= D457), F453 (≠ G459)
4kwgA Crystal structure analysis of aldh2+aldib13 (see paper)
44% identity, 96% coverage: 18:491/495 of query aligns to 14:485/494 of 4kwgA
- active site: N163 (= N166), K186 (= K189), E262 (= E265), C296 (= C300), E393 (= E399), E470 (≠ D476)
- binding 7-bromo-5-methyl-1H-indole-2,3-dione: F164 (≠ Y167), M168 (= M171), C295 (≠ V299), C296 (= C300), C297 (≠ N301), D451 (= D457), F453 (≠ G459)
4kwfA Crystal structure analysis of aldh2+aldib33 (see paper)
44% identity, 96% coverage: 18:491/495 of query aligns to 14:485/494 of 4kwfA
- active site: N163 (= N166), K186 (= K189), E262 (= E265), C296 (= C300), E393 (= E399), E470 (≠ D476)
- binding 1-benzyl-1H-indole-2,3-dione: F164 (≠ Y167), M168 (= M171), W171 (= W174), E262 (= E265), C295 (≠ V299), C296 (= C300), C297 (≠ N301), D451 (= D457), F453 (≠ G459), F459 (= F465)
3sz9A Crystal structure of human aldh2 modified with the beta-elimination product of aldi-3; 1-(4-ethylbenzene)prop-2-en-1-one (see paper)
44% identity, 96% coverage: 18:491/495 of query aligns to 14:485/494 of 3sz9A
- active site: N163 (= N166), K186 (= K189), E262 (= E265), C296 (= C300), E393 (= E399), E470 (≠ D476)
- binding 1-(4-ethylphenyl)propan-1-one: F164 (≠ Y167), C295 (≠ V299), C296 (= C300), D451 (= D457), F453 (≠ G459), F459 (= F465)
3injA Human mitochondrial aldehyde dehydrogenase complexed with agonist alda-1 (see paper)
44% identity, 96% coverage: 18:491/495 of query aligns to 14:485/494 of 3injA
- active site: N163 (= N166), K186 (= K189), E262 (= E265), C296 (= C300), E393 (= E399), E470 (≠ D476)
- binding N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide: M118 (≠ S121), F164 (≠ Y167), L167 (≠ S170), F286 (≠ A290), F290 (≠ A294), D451 (= D457), F453 (≠ G459)
2vleA The structure of daidzin, a naturally occurring anti alcohol- addiction agent, in complex with human mitochondrial aldehyde dehydrogenase (see paper)
44% identity, 96% coverage: 18:491/495 of query aligns to 14:485/494 of 2vleA
- active site: N163 (= N166), K186 (= K189), E262 (= E265), C296 (= C300), E393 (= E399), E470 (≠ D476)
- binding daidzin: M118 (≠ S121), F164 (≠ Y167), M168 (= M171), W171 (= W174), F286 (≠ A290), F290 (≠ A294), C295 (≠ V299), C296 (= C300), D451 (= D457), V452 (≠ R458), F453 (≠ G459)
1o01B Human mitochondrial aldehyde dehydrogenase complexed with crotonaldehyde, NAD(h) and mg2+ (see paper)
44% identity, 96% coverage: 18:491/495 of query aligns to 14:485/494 of 1o01B
- active site: N163 (= N166), K186 (= K189), E262 (= E265), C296 (= C300), E393 (= E399), E470 (≠ D476)
- binding (2e)-but-2-enal: C296 (= C300), C297 (≠ N301), F453 (≠ G459)
- binding nicotinamide-adenine-dinucleotide: I159 (≠ V162), I160 (≠ V163), P161 (= P164), W162 (= W165), K186 (= K189), E189 (= E192), G219 (= G222), G223 (= G226), A224 (≠ K227), F237 (= F240), G239 (= G242), S240 (= S243), I243 (≠ V246), L263 (= L266), G264 (= G267), C296 (= C300), Q343 (= Q347), E393 (= E399), F395 (= F401)
1cw3A Human mitochondrial aldehyde dehydrogenase complexed with NAD+ and mn2+ (see paper)
44% identity, 96% coverage: 18:491/495 of query aligns to 14:485/494 of 1cw3A
- active site: N163 (= N166), K186 (= K189), E262 (= E265), C296 (= C300), E393 (= E399), E470 (≠ D476)
- binding magnesium ion: V34 (≠ I38), D103 (≠ N106), Q190 (= Q193)
- binding nicotinamide-adenine-dinucleotide: I159 (≠ V162), I160 (≠ V163), P161 (= P164), W162 (= W165), K186 (= K189), G219 (= G222), G223 (= G226), A224 (≠ K227), F237 (= F240), G239 (= G242), S240 (= S243), I243 (≠ V246), L263 (= L266), G264 (= G267), C296 (= C300), Q343 (= Q347), K346 (≠ R350), E393 (= E399), F395 (= F401)
4fr8A Crystal structure of human aldehyde dehydrogenase-2 in complex with nitroglycerin (see paper)
44% identity, 96% coverage: 18:491/495 of query aligns to 13:484/493 of 4fr8A
- active site: N162 (= N166), K185 (= K189), Q261 (≠ E265), C295 (= C300), E392 (= E399), E469 (≠ D476)
- binding nicotinamide-adenine-dinucleotide: I158 (≠ V162), I159 (≠ V163), W161 (= W165), K185 (= K189), G218 (= G222), G222 (= G226), A223 (≠ K227), F236 (= F240), G238 (= G242), S239 (= S243), I242 (≠ V246), Q342 (= Q347), K345 (≠ R350), E392 (= E399), F394 (= F401)
- binding propane-1,2,3-triyl trinitrate: F163 (≠ Y167), L166 (≠ S170), W170 (= W174), F289 (≠ A294), S294 (≠ V299), C295 (= C300), D450 (= D457), F452 (≠ G459)
4fr8C Crystal structure of human aldehyde dehydrogenase-2 in complex with nitroglycerin (see paper)
44% identity, 96% coverage: 18:491/495 of query aligns to 16:487/496 of 4fr8C
- active site: N165 (= N166), K188 (= K189), Q264 (≠ E265), C298 (= C300), E395 (= E399), E472 (≠ D476)
- binding nicotinamide-adenine-dinucleotide: I161 (≠ V162), I162 (≠ V163), W164 (= W165), K188 (= K189), G221 (= G222), G225 (= G226), A226 (≠ K227), F239 (= F240), G241 (= G242), S242 (= S243), I245 (≠ V246), Q345 (= Q347), E395 (= E399), F397 (= F401)
P20000 Aldehyde dehydrogenase, mitochondrial; ALDH class 2; ALDH-E2; ALDHI; EC 1.2.1.3 from Bos taurus (Bovine) (see 2 papers)
44% identity, 96% coverage: 16:491/495 of query aligns to 38:511/520 of P20000
Sites not aligning to the query:
- 1:21 modified: transit peptide, Mitochondrion
1nzwA Cys302ser mutant of human mitochondrial aldehyde dehydrogenase complexed with nadh and mg2+ (see paper)
44% identity, 96% coverage: 18:491/495 of query aligns to 14:485/494 of 1nzwA
- active site: N163 (= N166), K186 (= K189), E262 (= E265), S296 (≠ C300), E393 (= E399), E470 (≠ D476)
- binding 1,4-dihydronicotinamide adenine dinucleotide: I159 (≠ V162), I160 (≠ V163), P161 (= P164), K186 (= K189), E189 (= E192), G219 (= G222), P220 (≠ H223), G223 (= G226), A224 (≠ K227), F237 (= F240), G239 (= G242), S240 (= S243), I243 (≠ V246), E262 (= E265), G264 (= G267), S296 (≠ C300), Q343 (= Q347), E393 (= E399), F395 (= F401)
2onmA Human mitochondrial aldehyde dehydrogenase asian variant, aldh2 2, Complexed with NAD+ (see paper)
44% identity, 95% coverage: 18:485/495 of query aligns to 14:479/494 of 2onmA
- active site: N163 (= N166), K186 (= K189), E262 (= E265), C296 (= C300), E393 (= E399), E470 (≠ D476)
- binding adenosine-5'-diphosphate: E189 (= E192), G219 (= G222), G223 (= G226), A224 (≠ K227), F237 (= F240), G239 (= G242), S240 (= S243), I243 (≠ V246)
5gtlA NADPH complex structure of aldehyde dehydrogenase from bacillus cereus
42% identity, 96% coverage: 19:492/495 of query aligns to 18:487/491 of 5gtlA
- active site: N165 (= N166), K188 (= K189), E263 (= E265), C297 (= C300), E394 (= E399), E471 (≠ D476)
- binding nadph dihydro-nicotinamide-adenine-dinucleotide phosphate: I161 (≠ V162), P163 (= P164), K188 (= K189), A190 (= A191), E191 (= E192), Q192 (= Q193), G221 (= G222), G225 (= G226), G241 (= G242), S242 (= S243), T245 (≠ V246), L264 (= L266), C297 (= C300), E394 (= E399), F396 (= F401)
Query Sequence
>WP_011842150.1 NCBI__GCF_000015985.1:WP_011842150.1
MLQEIDWHARAKAVALPNRPFIDGQYVDSLSGETFACIYPGDGRPLTDVASCNAADVDVA
VRSARRAFEAGVWSRMAPADRRRILLRFSELILANREELALLETLNVGKPIANAYNGDVV
SAAACIAWYAEAIDKVYGEVAATAHDMTTLVMREPLGIVAAVVPWNYPMSMAAWKLGPAL
ATGNSVILKPAEQSPFTALKFGELAIEAGMPPGVLNVVPGLGHIAGKALGLHMDVDCVGF
TGSTEVGKYFMQYSGQSNIKRIGLELGGKSPQVVLADCDDLDAAAAGIAAGIFANTGQVC
NAGSRLIVDEKIHDQLLEKIAAQAKVFAPGDPLDTATRMGSMVSEEQMDRVLGYIDAGRA
DGARPVIGGGRVKTETGGFYIEPTIFEGVRNDMKIAQEEIFGPVLSAIPVKGFDEAMAVA
NDTVYGLAGAVWTGSVKNAHRAAKSLRAGVVWVNCFDRGSLAVPFGGFKQSGFGRDKSLH
AMDKYTDLKAVWFAH
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory