SitesBLAST
Comparing WP_011842152.1 NCBI__GCF_000015985.1:WP_011842152.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
6iunB Crystal structure of enoyl-coa hydratase (ech) from ralstonia eutropha h16 in complex with NAD
41% identity, 97% coverage: 12:644/655 of query aligns to 8:650/692 of 6iunB
- active site: A60 (= A64), F65 (= F69), E73 (≠ A75), H77 (≠ P79), G101 (= G103), E104 (= E106), E124 (= E126), G132 (= G134), K248 (≠ R248), S407 (= S406), H428 (= H427), E440 (= E439), N478 (= N477)
- binding nicotinamide-adenine-dinucleotide: G300 (= G299), T301 (= T300), M302 (= M301), E321 (= E320), T322 (= T321), Y365 (≠ L364), A377 (= A376), V378 (= V377), E380 (= E379), V384 (= V383), V388 (= V387), N405 (= N404), S407 (= S406)
Q08426 Peroxisomal bifunctional enzyme; PBE; PBFE; L-bifunctional protein; LBP; Multifunctional enzyme 1; MFE1; EC 4.2.1.17; EC 5.3.3.8; EC 1.1.1.35 from Homo sapiens (Human) (see 5 papers)
38% identity, 97% coverage: 12:645/655 of query aligns to 9:668/723 of Q08426
- V40 (≠ E43) to G: in dbSNP:rs1062551
- I41 (≠ A44) to R: in dbSNP:rs1062552
- T75 (≠ H77) to I: in dbSNP:rs1062553
- K165 (≠ E167) modified: N6-acetyllysine; alternate; mutation to Q: Greatly reduced acetylation and insensitive to treatment with TSA and NAM; when associated with Q-171; Q-346 and Q-584.
- K171 (≠ R173) modified: N6-acetyllysine; mutation to Q: Greatly reduced acetylation and insensitive to treatment with TSA and NAM; when associated with Q-165; Q-346 and Q-584.
- A274 (= A272) to T: in dbSNP:rs2302819
- A325 (≠ L318) to G: in dbSNP:rs1062555
- K346 (≠ A339) modified: N6-acetyllysine; mutation to Q: Greatly reduced acetylation and insensitive to treatment with TSA and NAM; when associated with Q-165; Q-171 and Q-584.
- K584 (≠ A565) modified: N6-acetyllysine; alternate; mutation to Q: Greatly reduced acetylation and insensitive to treatment with TSA and NAM; when associated with Q-165; Q-171 and Q-346.
- K598 (≠ A579) to T: in dbSNP:rs1042437
- T606 (= T586) to P: in dbSNP:rs1042438
Sites not aligning to the query:
- 3 E → K: in FRTS3; the mutant is mistargeted to mitochondria; results in impaired mitochondrial oxidative phosphorylation and defects in the transport of fluids across the epithelium of renal proximal tubular cells; dbSNP:rs398124646
3zw9A Crystal structure of rat peroxisomal multifunctional enzyme type 1 (rpmfe1) complexed with (2s,3s)-3-hydroxy-2-methylbutanoyl-coa (see paper)
37% identity, 96% coverage: 14:645/655 of query aligns to 14:670/723 of 3zw9A
- active site: A64 (= A64), F69 (= F69), G79 (≠ P79), G103 (= G103), E106 (= E106), P125 (= P125), E126 (= E126), P133 (= P133), G134 (= G134), K252 (≠ R248), S413 (= S406), H434 (= H427), E446 (= E439), N484 (= N477)
- binding nicotinamide-adenine-dinucleotide: L305 (≠ I296), G306 (= G297), G308 (= G299), T309 (= T300), M310 (= M301), E329 (= E320), Q334 (≠ A325), A383 (= A376), V384 (= V377), F385 (= F378), E386 (= E379), N411 (= N404), S413 (= S406), H434 (= H427)
- binding (2s,3s)-3-hydroxy-2-methylbutanoyl-coa: V24 (= V24), A62 (≠ G62), G63 (= G63), A64 (= A64), I66 (= I66), G102 (= G102), G103 (= G103), E106 (= E106), E126 (= E126), P133 (= P133), Y159 (≠ T159)
3zwaA Crystal structure of rat peroxisomal multifunctional enzyme type 1 (rpmfe1) complexed with 3s-hydroxy-hexanoyl-coa (see paper)
37% identity, 96% coverage: 14:645/655 of query aligns to 17:673/727 of 3zwaA
- active site: A67 (= A64), F72 (= F69), G82 (≠ P79), G106 (= G103), E109 (= E106), P128 (= P125), E129 (= E126), P136 (= P133), G137 (= G134), K255 (≠ R248), S416 (= S406), H437 (= H427), E449 (= E439), N487 (= N477)
- binding (S)-3-Hydroxyhexanoyl-CoA: V27 (= V24), A65 (≠ G62), G66 (= G63), A67 (= A64), D68 (= D65), I69 (= I66), L104 (= L101), E109 (= E106), R124 (= R121), E129 (= E126), L132 (= L129), G137 (= G134), Y162 (≠ T159)
5omoA Crystal structure of rat peroxisomal multifunctional enzyme type-1 (rpmfe1) complexed with with 3s-hydroxy-decanoyl-coa and 3-keto- decanoyl-coa
37% identity, 96% coverage: 14:645/655 of query aligns to 16:672/725 of 5omoA
- active site: A66 (= A64), F71 (= F69), G81 (≠ P79), G105 (= G103), E108 (= E106), P127 (= P125), E128 (= E126), P135 (= P133), G136 (= G134), K254 (≠ R248), S415 (= S406), H436 (= H427), E448 (= E439), N486 (= N477)
- binding (s)-3-hydroxydecanoyl-coa: P25 (= P23), V26 (= V24), A28 (= A26), P31 (≠ L29), A64 (≠ G62), A66 (= A64), D67 (= D65), I68 (= I66), L103 (= L101), G105 (= G103), E108 (= E106), P127 (= P125), E128 (= E126), Y161 (≠ T159), F260 (= F254), K280 (≠ R274)
- binding 3-keto-decanoyl-coa: S415 (= S406), N486 (= N477), K519 (≠ G510), M520 (= M511), V525 (≠ M516), Y658 (= Y631)
5mgbA Crystal structure of rat peroxisomal multifunctional enzyme type-1 (rpmfe1) complexed with acetoacetyl-coa and NAD (see paper)
37% identity, 96% coverage: 14:645/655 of query aligns to 16:672/725 of 5mgbA
- active site: A66 (= A64), F71 (= F69), G81 (≠ P79), G105 (= G103), E108 (= E106), P127 (= P125), E128 (= E126), P135 (= P133), G136 (= G134), K254 (≠ R248), S415 (= S406), H436 (= H427), E448 (= E439), N486 (= N477)
- binding acetoacetyl-coenzyme a: P25 (= P23), V26 (= V24), A64 (≠ G62), G65 (= G63), A66 (= A64), D67 (= D65), I68 (= I66), G105 (= G103), E128 (= E126), Y161 (≠ T159)
- binding nicotinamide-adenine-dinucleotide: L307 (≠ I296), G308 (= G297), G310 (= G299), T311 (= T300), M312 (= M301), E331 (= E320), S332 (≠ T321), Q336 (≠ A325), V386 (= V377), F387 (= F378), E388 (= E379), N413 (= N404), S415 (= S406), H436 (= H427)
3zwcA Crystal structure of rat peroxisomal multifunctional enzyme type 1 (rpmfe1) complexed with 3s-hydroxy-decanoyl-coa (see paper)
37% identity, 96% coverage: 14:645/655 of query aligns to 16:672/725 of 3zwcA
- active site: A66 (= A64), F71 (= F69), G81 (≠ P79), G105 (= G103), E108 (= E106), P127 (= P125), E128 (= E126), P135 (= P133), G136 (= G134), K254 (≠ R248), S415 (= S406), H436 (= H427), E448 (= E439), N486 (= N477)
- binding (s)-3-hydroxydecanoyl-coa: V26 (= V24), A64 (≠ G62), G65 (= G63), A66 (= A64), D67 (= D65), I68 (= I66), G77 (≠ A75), L78 (≠ P76), L80 (= L78), V101 (≠ A99), G104 (= G102), G105 (= G103), E108 (= E106), E128 (= E126), F260 (= F254)
- binding nicotinamide-adenine-dinucleotide: G308 (= G297), G310 (= G299), T311 (= T300), M312 (= M301), E331 (= E320), Q336 (≠ A325), A385 (= A376), V386 (= V377), F387 (= F378), E388 (= E379), K393 (= K384), N413 (= N404), S415 (= S406), H436 (= H427)
2x58A The crystal structure of mfe1 liganded with coa (see paper)
37% identity, 96% coverage: 14:645/655 of query aligns to 16:672/725 of 2x58A
- active site: A66 (= A64), F71 (= F69), G81 (≠ P79), G105 (= G103), E108 (= E106), P127 (= P125), E128 (= E126), P135 (= P133), G136 (= G134), K254 (≠ R248), S415 (= S406), H436 (= H427), E448 (= E439), N486 (= N477)
- binding adenosine-5'-diphosphate: G310 (= G299), T311 (= T300), M312 (= M301), E331 (= E320), S332 (≠ T321), Q336 (≠ A325), V386 (= V377), L392 (≠ V383)
- binding coenzyme a: V26 (= V24), A28 (= A26), A64 (≠ G62), A66 (= A64), D67 (= D65), I68 (= I66), E128 (= E126)
6zicAAA structure of rat peroxisomal multifunctional enzyme type-1 (rpmfe1) complexed with 3s-hydroxybutanoyl-coa and nadh'
38% identity, 96% coverage: 14:645/655 of query aligns to 16:670/723 of 6zicAAA
- active site: A66 (= A64), F71 (= F69), G81 (≠ P79), G105 (= G103), E108 (= E106), P127 (= P125), E128 (= E126), G136 (= G134), K254 (≠ R248), S413 (= S406), H434 (= H427), E446 (= E439), N484 (= N477)
- binding 3-hydroxybutanoyl-coenzyme a: P25 (= P23), V26 (= V24), A28 (= A26), A66 (= A64), D67 (= D65), I68 (= I66), G104 (= G102), G105 (= G103), E108 (= E106), E128 (= E126), Y161 (≠ T159)
- binding 1,4-dihydronicotinamide adenine dinucleotide: G308 (= G297), G310 (= G299), T311 (= T300), M312 (= M301), E331 (= E320), S332 (≠ T321), Q336 (≠ A325), A383 (= A376), V384 (= V377), F385 (= F378), E386 (= E379), L390 (≠ V383), K391 (= K384), N411 (= N404), S413 (= S406), H434 (= H427)
6zibAAA structure of rat peroxisomal multifunctional enzyme type-1 (rpmfe1) complexed with acetoacetyl-coa and nadh'
38% identity, 96% coverage: 14:645/655 of query aligns to 16:670/723 of 6zibAAA
- active site: A66 (= A64), F71 (= F69), G81 (≠ P79), G105 (= G103), E108 (= E106), P127 (= P125), E128 (= E126), G136 (= G134), K254 (≠ R248), S413 (= S406), H434 (= H427), E446 (= E439), N484 (= N477)
- binding acetoacetyl-coenzyme a: P25 (= P23), V26 (= V24), A64 (≠ G62), G65 (= G63), A66 (= A64), D67 (= D65), I68 (= I66), G104 (= G102), G105 (= G103), E128 (= E126), Y161 (≠ T159)
- binding 1,4-dihydronicotinamide adenine dinucleotide: G310 (= G299), T311 (= T300), M312 (= M301), E331 (= E320), S332 (≠ T321), Q336 (≠ A325), A383 (= A376), V384 (= V377), F385 (= F378), E386 (= E379), N411 (= N404), H434 (= H427)
3zwbA Crystal structure of rat peroxisomal multifunctional enzyme type 1 (rpmfe1) complexed with 2trans-hexenoyl-coa (see paper)
37% identity, 96% coverage: 14:645/655 of query aligns to 16:672/725 of 3zwbA
- active site: A66 (= A64), G81 (≠ P79), G105 (= G103), E108 (= E106), P127 (= P125), A128 (≠ E126), P135 (= P133), G136 (= G134), S415 (= S406), H436 (= H427), E448 (= E439), N486 (= N477)
- binding (2E)-Hexenoyl-CoA: P25 (= P23), V26 (= V24), A28 (= A26), A64 (≠ G62), G65 (= G63), A66 (= A64), D67 (= D65), I68 (= I66), V101 (≠ A99), L103 (= L101), G105 (= G103), E108 (= E106), G136 (= G134), Y161 (≠ T159), K280 (≠ R274)
6z5oAAA Peroxisomal bifunctional enzyme (see paper)
38% identity, 96% coverage: 14:645/655 of query aligns to 17:666/716 of 6z5oAAA
- active site: A67 (= A64), F72 (= F69), G82 (≠ P79), G106 (= G103), E109 (= E106), P128 (= P125), E129 (= E126), G137 (= G134), K255 (≠ R248), S409 (= S406), H430 (= H427), E442 (= E439), N480 (= N477)
- binding coenzyme a: P26 (= P23), V27 (= V24), A65 (≠ G62), D68 (= D65), I69 (= I66), P128 (= P125), Y162 (≠ T159), F277 (= F270), K281 (≠ R274)
- binding nicotinamide-adenine-dinucleotide: G309 (= G297), G311 (= G299), T312 (= T300), M313 (= M301), E332 (= E320), S333 (≠ T321), Q337 (≠ A325), A379 (= A376), V380 (= V377), F381 (= F378), E382 (= E379), K387 (= K384), N407 (= N404), S409 (= S406), H430 (= H427)
- binding nicotinamide: A67 (= A64), E109 (= E106), E129 (= E126), P136 (= P133), F261 (= F254)
6yswA E. Coli anaerobic trifunctional enzyme subunit-alpha in complex with coenzyme a
35% identity, 96% coverage: 11:641/655 of query aligns to 10:660/707 of 6yswA
- active site: A66 (= A64), I71 (vs. gap), A84 (vs. gap), Q88 (≠ P79), G112 (= G103), E115 (= E106), P136 (= P125), E137 (= E126), G145 (= G134), D264 (≠ R248), S422 (= S406), H443 (= H427), E455 (= E439), N493 (= N477)
- binding coenzyme a: E23 (vs. gap), M25 (≠ V24), A66 (= A64), D67 (= D65), I68 (= I66), P136 (= P125), E137 (= E126), L140 (= L129), T290 (≠ R274), K293 (≠ L277)
P40939 Trifunctional enzyme subunit alpha, mitochondrial; 78 kDa gastrin-binding protein; Monolysocardiolipin acyltransferase; TP-alpha; EC 2.3.1.-; EC 4.2.1.17; EC 1.1.1.211 from Homo sapiens (Human) (see 5 papers)
30% identity, 96% coverage: 21:651/655 of query aligns to 58:732/763 of P40939
- V282 (≠ F210) to D: in MTPD1; mild phenotype with slowly progressive myopathy and sensorimotor polyneuropathy; dbSNP:rs137852773
- I305 (≠ L232) to N: in MTPD1; mild phenotype with slowly progressive myopathy and sensorimotor polyneuropathy; dbSNP:rs137852774
- L342 (= L269) to P: in LCHAD deficiency; dbSNP:rs137852772
- E510 (= E439) active site, For hydroxyacyl-coenzyme A dehydrogenase activity; to Q: in AFLP and LCHAD deficiency; loss of long-chain-3-hydroxyacyl-CoA dehydrogenase activity; dbSNP:rs137852769
7o4uA Structure of the alpha subunit of mycobacterium tuberculosis beta- oxidation trifunctional enzyme in complex with oxidized nicotinamide adenine dinucleotide (see paper)
32% identity, 97% coverage: 3:639/655 of query aligns to 2:669/711 of 7o4uA
4b3iA Crystal structure of mycobacterium tuberculosis fatty acid beta- oxidation complex with coenzymea bound at the hydratase active sites (see paper)
32% identity, 97% coverage: 3:639/655 of query aligns to 15:689/731 of 4b3iA
- active site: G79 (≠ A64), E100 (≠ A83), R104 (vs. gap), G127 (= G103), E130 (= E106), P151 (= P125), E152 (= E126), G160 (= G134), S452 (= S406), H473 (= H427), E485 (= E439), S523 (≠ N477)
- binding adenosine-5'-diphosphate: Q640 (≠ R590), P641 (= P591), P642 (≠ S592), L643 (≠ G593), Q644 (≠ T594)
- binding coenzyme a: T38 (≠ V24), V40 (≠ A26), A77 (≠ G62), G79 (≠ A64), D80 (= D65), V81 (≠ I66), E152 (= E126), F315 (= F271), Q319 (≠ A275)
8oqoA Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with fragment-m-49
32% identity, 97% coverage: 3:639/655 of query aligns to 12:686/727 of 8oqoA
8oqlA Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with fragment-m-1
32% identity, 97% coverage: 3:639/655 of query aligns to 12:686/728 of 8oqlA
- binding Hexafluorophosphate anion: V37 (≠ A26), N39 (≠ G28), G75 (= G63), D77 (= D65), M81 (≠ F69), V92 (≠ L78), T95 (≠ V81), P148 (= P125), E149 (= E126), L152 (= L129), Q180 (≠ A156), Q260 (≠ R217), K362 (≠ T319), D363 (≠ E320), V364 (≠ T321), V430 (= V387), D476 (≠ Q433), K477 (≠ V434), M478 (= M435), P479 (≠ K436), K506 (= K463)
- binding formamide: V78 (≠ I66), K79 (≠ A67)
8oqsB Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with fragment-m-83
32% identity, 97% coverage: 3:639/655 of query aligns to 19:693/735 of 8oqsB
- binding 4-phenylbenzenesulfonic acid: M45 (≠ L27), I50 (≠ R32), G82 (= G63), G83 (≠ A64), D84 (= D65), T87 (≠ E68), T87 (≠ E68), M88 (≠ F69), M88 (≠ F69), A91 (≠ D70), D95 (≠ E74), D98 (≠ H77), V99 (≠ L78), T102 (≠ V81), T102 (≠ V81), E134 (= E106), E156 (= E126), L159 (= L129), F302 (= F254), F302 (= F254), F319 (= F271), S456 (= S406), T457 (≠ Y407), M485 (= M435), P486 (≠ K436), G523 (= G473), S527 (≠ N477), N535 (≠ A485), P560 (≠ G510), M575 (≠ A525), I578 (≠ A528), I578 (≠ A528), I682 (≠ V628), M683 (≠ H629), G686 (= G632)
Sites not aligning to the query:
8oqrA Structure of mycobacterium tuberculosis beta-oxidation trifunctional enzyme in complex with fragment-m-80
32% identity, 97% coverage: 3:639/655 of query aligns to 13:687/728 of 8oqrA
- binding 4-cyanobenzenesulfonic acid: G76 (= G63), G77 (≠ A64), T81 (≠ E68), M82 (≠ F69), M82 (≠ F69), A85 (≠ D70), D89 (≠ E74), T96 (≠ V81), L123 (= L101), G124 (= G102), P149 (= P125), E150 (= E126), S366 (≠ G322), L367 (≠ P323), E368 (= E324), A420 (= A376), V421 (= V377), F422 (= F378)
Query Sequence
>WP_011842152.1 NCBI__GCF_000015985.1:WP_011842152.1
MTNDLIRRSDFDGIALLTLANPPVNALGLAVRQRLTALTAELEADESVRAVVLTAEGRVF
VGGADIAEFDRPPEAPHLPDVIAAIEASRKPWIAALNGAALGGGAELALGCHYRIFADTA
RLGLPETSLGLIPGAGGTQRLPRRIGLAPAIEVITAGRTLSAAEAREAGLADRIAAGELI
PEALAFARTLDGALPRPASAAPLADPGHAFWDEARARIARAARGNPAPTAALEAIRAGVA
EGFAAGLRAERETFLRLRASDEAAALRHLFFAERAALRPAALRGIEPVPLTRAGVIGGGT
MGSGIAAALAAAGLEVRLTETGPEALAAGLERVEAIFEAQVKRGLTDRAGATERMARVTG
TVGLGALADCDLVIEAVFEDLAVKRRVFEELVRLCGPEAILATNTSYLDPERIVEGLPHP
HRFIALHFFSPAQVMKLLEIVPLAATAPRILATGVALAARLGKIPVQAGNGEGFIGNRIL
KRYRAEAEALLLAGATPTEIDEAMRAFGLGMGPFEMQDMAGLDIAFRAREAARALGQDLP
EGPGDRLVRAGRLGRKSGGGWYDYAPGSRLPQPSPEAAALIAPLVTPGARPSGTEIADRL
IAAMAEEGQRICDEGLAQSPSDIDLVEVHGYGFPRHKGGPMFHAARKTRSRTSGA
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory