SitesBLAST
Comparing WP_011842743.1 NCBI__GCF_000015985.1:WP_011842743.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
4n5fA Crystal structure of a putative acyl-coa dehydrogenase with bound fadh2 from burkholderia cenocepacia j2315
52% identity, 99% coverage: 3:374/377 of query aligns to 5:376/378 of 4n5fA
- active site: L126 (= L124), T127 (= T125), G243 (= G241), E364 (= E362), R376 (= R374)
- binding dihydroflavine-adenine dinucleotide: L126 (= L124), T127 (= T125), G132 (= G130), S133 (= S131), F157 (= F155), T159 (= T157), T210 (= T208), Y363 (= Y361), T366 (= T364), E368 (≠ D366), M372 (= M370)
4m9aB Crystal structure of acyl-coa dehydrogenase from burkholderia thailandensis e264
50% identity, 99% coverage: 2:376/377 of query aligns to 2:376/376 of 4m9aB
- active site: L124 (= L124), T125 (= T125), G241 (= G241), E362 (= E362), R374 (= R374)
- binding dihydroflavine-adenine dinucleotide: F122 (= F122), T125 (= T125), G130 (= G130), S131 (= S131), F155 (= F155), T157 (= T157), T208 (= T208), Y361 (= Y361), T364 (= T364), E366 (≠ D366), M370 (= M370)
5lnxD Crystal structure of mmgc, an acyl-coa dehydrogenase from bacillus subtilis.
45% identity, 97% coverage: 7:372/377 of query aligns to 5:368/374 of 5lnxD
- active site: L122 (= L124), T123 (= T125), G239 (= G241), E358 (= E362)
- binding flavin-adenine dinucleotide: L122 (= L124), T123 (= T125), G128 (= G130), S129 (= S131), F153 (= F155), T155 (= T157), R265 (= R267), Q267 (≠ S269), F268 (= F270), I272 (≠ L274), N275 (≠ H277), I278 (≠ V280), Q331 (= Q335), I332 (≠ T336), G335 (= G339), Y357 (= Y361), T360 (= T364), E362 (≠ D366)
Sites not aligning to the query:
4l1fA Electron transferring flavoprotein of acidaminococcus fermentans: towards a mechanism of flavin-based electron bifurcation (see paper)
42% identity, 99% coverage: 4:376/377 of query aligns to 5:377/380 of 4l1fA
- active site: L125 (= L124), T126 (= T125), G242 (= G241), E363 (= E362), R375 (= R374)
- binding coenzyme a persulfide: T132 (≠ S131), H179 (≠ E178), F232 (≠ Y231), M236 (≠ L235), E237 (≠ S236), L239 (= L238), D240 (≠ E239), R243 (= R242), Y362 (= Y361), E363 (= E362), G364 (= G363), R375 (= R374)
- binding flavin-adenine dinucleotide: F123 (= F122), L125 (= L124), T126 (= T125), G131 (= G130), T132 (≠ S131), F156 (= F155), I157 (= I156), T158 (= T157), R268 (= R267), Q270 (≠ S269), F271 (= F270), I275 (≠ L274), F278 (≠ H277), L281 (≠ V280), Q336 (= Q335), I337 (≠ T336), G340 (= G339), I358 (≠ V357), Y362 (= Y361), T365 (= T364), Q367 (≠ D366)
- binding 1,3-propandiol: L5 (= L4), Q10 (≠ R9)
P15651 Short-chain specific acyl-CoA dehydrogenase, mitochondrial; SCAD; Butyryl-CoA dehydrogenase; EC 1.3.8.1 from Rattus norvegicus (Rat) (see 2 papers)
43% identity, 98% coverage: 4:372/377 of query aligns to 34:402/412 of P15651
- 152:161 (vs. 122:131, 60% identical) binding FAD
- S161 (= S131) binding substrate
- WIT 185:187 (≠ FIT 155:157) binding FAD
- DMGR 269:272 (≠ ETGR 239:242) binding substrate
- R297 (= R267) binding FAD
- QILGG 365:369 (≠ QTFGG 335:339) binding FAD
- E392 (= E362) active site, Proton acceptor
- TSE 394:396 (≠ TSD 364:366) binding FAD
Sites not aligning to the query:
- 1:24 modified: transit peptide, Mitochondrion
1jqiA Crystal structure of rat short chain acyl-coa dehydrogenase complexed with acetoacetyl-coa (see paper)
43% identity, 98% coverage: 4:372/377 of query aligns to 7:375/384 of 1jqiA
- binding acetoacetyl-coenzyme a: L95 (≠ P92), F125 (= F122), S134 (= S131), F234 (≠ Y231), M238 (≠ L235), Q239 (≠ S236), L241 (= L238), D242 (≠ E239), R245 (= R242), Y364 (= Y361), E365 (= E362), G366 (= G363)
- binding flavin-adenine dinucleotide: F125 (= F122), L127 (= L124), S128 (≠ T125), G133 (= G130), S134 (= S131), W158 (≠ F155), T160 (= T157), R270 (= R267), F273 (= F270), L280 (≠ H277), Q338 (= Q335), I339 (≠ T336), G342 (= G339), I360 (≠ V357), T367 (= T364), E369 (≠ D366), I370 (= I367)
Sites not aligning to the query:
8sgsA Human liver mitochondrial short-chain specific acyl-coa dehydrogenase (see paper)
43% identity, 98% coverage: 4:372/377 of query aligns to 4:372/381 of 8sgsA
- binding coenzyme a: S131 (= S131), A133 (= A133), N177 (≠ K177), F231 (≠ Y231), M235 (≠ L235), L238 (= L238), I312 (≠ L312), E362 (= E362), G363 (= G363)
- binding flavin-adenine dinucleotide: F122 (= F122), L124 (= L124), S125 (≠ T125), G130 (= G130), S131 (= S131), W155 (≠ F155), T157 (= T157), R267 (= R267), F270 (= F270), L274 (= L274), L277 (≠ H277), Q335 (= Q335), I336 (≠ T336), G338 (= G338), G339 (= G339), I357 (≠ V357), I360 (= I360), Y361 (= Y361), T364 (= T364), E366 (≠ D366)
7y0bA Crystal structure of human short-chain acyl-coa dehydrogenase
43% identity, 98% coverage: 4:372/377 of query aligns to 7:375/385 of 7y0bA
- binding (2S,3R,4R,5S,6R)-2-[4-chloranyl-3-[[4-[(3S)-oxolan-3-yl]oxyphenyl]methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triol: M343 (≠ Y340), T347 (≠ R344), E348 (≠ D345)
- binding flavin-adenine dinucleotide: F125 (= F122), L127 (= L124), S128 (≠ T125), G133 (= G130), S134 (= S131), W158 (≠ F155), T160 (= T157), R270 (= R267), F273 (= F270), L280 (≠ H277), V282 (≠ A279), Q338 (= Q335), I339 (≠ T336), G342 (= G339), I360 (≠ V357), Y364 (= Y361), T367 (= T364), E369 (≠ D366), I370 (= I367), L373 (≠ M370)
7y0aC Crystal structure of human short-chain acyl-coa dehydrogenase
43% identity, 98% coverage: 4:372/377 of query aligns to 10:378/387 of 7y0aC
- binding flavin-adenine dinucleotide: F128 (= F122), L130 (= L124), S131 (≠ T125), G136 (= G130), S137 (= S131), W161 (≠ F155), T163 (= T157), T214 (= T208), R273 (= R267), F276 (= F270), L280 (= L274), L283 (≠ H277), V285 (≠ A279), Q341 (= Q335), I342 (≠ T336), G345 (= G339), I363 (≠ V357), Y367 (= Y361), T370 (= T364), E372 (≠ D366), L376 (≠ M370)
P16219 Short-chain specific acyl-CoA dehydrogenase, mitochondrial; SCAD; Butyryl-CoA dehydrogenase; EC 1.3.8.1 from Homo sapiens (Human) (see 3 papers)
43% identity, 98% coverage: 4:372/377 of query aligns to 34:402/412 of P16219
- G90 (= G60) to S: in ACADSD; loss of acyl-CoA dehydrogenase activity; dbSNP:rs121908005
- E104 (= E74) natural variant: Missing (in ACADSD; loss of acyl-CoA dehydrogenase activity; dbSNP:rs387906308)
- 152:161 (vs. 122:131, 60% identical) binding in other chain
- R171 (= R141) to W: 69% of wild-type acyl-CoA dehydrogenase activity; confers susceptibility to ethylmalonicaciduria; dbSNP:rs1800556
- WIT 185:187 (≠ FIT 155:157) binding in other chain
- A192 (= A162) to V: in ACADSD; loss of acyl-CoA dehydrogenase activity; dbSNP:rs28940874
- G209 (= G179) to S: 86% of wild-type acyl-CoA dehydrogenase activity; confers susceptibility to ethylmalonicaciduria; dbSNP:rs1799958
- R297 (= R267) binding FAD
- Q308 (= Q278) binding in other chain
- R325 (= R295) to W: in ACADSD; loss of acyl-CoA dehydrogenase activity; dbSNP:rs121908006
- S353 (= S323) to L: in ACADSD; loss of acyl-CoA dehydrogenase activity; dbSNP:rs28941773
- QILGG 365:369 (≠ QTFGG 335:339) binding FAD
- R380 (= R350) to W: in ACADSD; loss of acyl-CoA dehydrogenase activity; dbSNP:rs28940875
- TSE 394:396 (≠ TSD 364:366) binding in other chain
Sites not aligning to the query:
- 1:24 modified: transit peptide, Mitochondrion
5ol2F The electron transferring flavoprotein/butyryl-coa dehydrogenase complex from clostridium difficile (see paper)
39% identity, 99% coverage: 1:372/377 of query aligns to 1:372/378 of 5ol2F
- active site: L124 (= L124), T125 (= T125), G241 (= G241)
- binding calcium ion: E29 (≠ A29), E33 (≠ A33), R35 (≠ A35)
- binding coenzyme a persulfide: L238 (= L238), R242 (= R242), E362 (= E362), G363 (= G363)
- binding flavin-adenine dinucleotide: F122 (= F122), L124 (= L124), T125 (= T125), P127 (≠ A127), T131 (≠ S131), F155 (= F155), I156 (= I156), T157 (= T157), E198 (= E198), R267 (= R267), F270 (= F270), L274 (= L274), F277 (≠ H277), Q335 (= Q335), L336 (≠ T336), G338 (= G338), G339 (= G339), Y361 (= Y361), T364 (= T364), E366 (≠ D366)
Sites not aligning to the query:
2dvlA Crystal structure of project tt0160 from thermus thermophilus hb8
47% identity, 99% coverage: 4:376/377 of query aligns to 1:368/370 of 2dvlA
- active site: L121 (= L124), T122 (= T125), G233 (= G241), E354 (= E362), R366 (= R374)
- binding flavin-adenine dinucleotide: L121 (= L124), T122 (= T125), G127 (= G130), S128 (= S131), W152 (≠ F155), I153 (= I156), T154 (= T157), T356 (= T364), E358 (≠ D366)
2vigB Crystal structure of human short-chain acyl coa dehydrogenase
43% identity, 98% coverage: 4:372/377 of query aligns to 1:362/371 of 2vigB
- active site: L121 (= L124), S122 (≠ T125), G231 (= G241), E352 (= E362)
- binding coenzyme a persulfide: S128 (= S131), F221 (≠ Y231), M225 (≠ L235), Q226 (≠ S236), L228 (= L238), D229 (≠ E239), R232 (= R242), E352 (= E362), G353 (= G363), I357 (= I367)
- binding flavin-adenine dinucleotide: L121 (= L124), S122 (≠ T125), G127 (= G130), S128 (= S131), W152 (≠ F155), T154 (= T157), R257 (= R267), F260 (= F270), L264 (= L274), L267 (≠ H277), Q325 (= Q335), I326 (≠ T336), G329 (= G339), I347 (≠ V357), Y351 (= Y361), T354 (= T364), E356 (≠ D366)
Sites not aligning to the query:
2jifA Structure of human short-branched chain acyl-coa dehydrogenase (acadsb)
39% identity, 98% coverage: 1:368/377 of query aligns to 3:369/381 of 2jifA
- active site: L125 (= L124), S126 (≠ T125), G242 (= G241), E363 (= E362)
- binding coenzyme a persulfide: S132 (= S131), S134 (≠ A133), Y178 (≠ K177), Y232 (= Y231), I236 (≠ L235), L239 (= L238), N240 (≠ E239), R243 (= R242), Y362 (= Y361), E363 (= E362), G364 (= G363), I368 (= I367)
- binding flavin-adenine dinucleotide: F123 (= F122), L125 (= L124), S126 (≠ T125), G131 (= G130), S132 (= S131), W156 (≠ F155), I157 (= I156), S158 (≠ T157), K201 (= K200), T209 (= T208), R268 (= R267), F271 (= F270), L275 (= L274), F278 (≠ H277), L281 (≠ V280), E336 (≠ Q335), W337 (≠ T336), G340 (= G339), N367 (≠ D366), I368 (= I367)
Sites not aligning to the query:
P45954 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial; SBCAD; 2-methyl branched chain acyl-CoA dehydrogenase; 2-MEBCAD; 2-methylbutyryl-coenzyme A dehydrogenase; 2-methylbutyryl-CoA dehydrogenase; EC 1.3.8.5 from Homo sapiens (Human) (see 6 papers)
39% identity, 98% coverage: 1:368/377 of query aligns to 54:420/432 of P45954
- V137 (≠ T84) mutation to L: Decreased acyl-CoA dehydrogenase activity.
- F138 (≠ V85) mutation to L: Increased acyl-CoA dehydrogenase activity. No effect on substrate specificity.
- 174:183 (vs. 122:131, 70% identical) binding in other chain
- S183 (= S131) binding substrate
- WIS 207:209 (≠ FIT 155:157) binding in other chain
- S210 (= S158) mutation to N: Increased acyl-CoA dehydrogenase activity. Changed substrate specificity.
- Y229 (≠ K177) binding substrate
- L255 (≠ Q203) to F: in SBCADD; loss of protein expression; loss of 2-methylbutyryl-CoA dehydrogenase activity; dbSNP:rs137852649
- Y283 (= Y231) binding substrate
- NEGR 291:294 (≠ ETGR 239:242) binding substrate
- I316 (≠ A264) to V: in dbSNP:rs1131430
- R319 (= R267) binding FAD
- Q330 (= Q278) binding FAD
- EWMGG 387:391 (≠ QTFGG 335:339) binding FAD
- A416 (≠ T364) mutation to T: Increased acyl-CoA dehydrogenase activity. No effect on substrate specificity.
- ASN 416:418 (≠ TSD 364:366) binding in other chain
Sites not aligning to the query:
- 1:33 modified: transit peptide, Mitochondrion
- 13 R → K: in dbSNP:rs12263012
1ukwB Crystal structure of medium-chain acyl-coa dehydrogenase from thermus thermophilus hb8
39% identity, 99% coverage: 4:376/377 of query aligns to 5:376/379 of 1ukwB
- active site: L124 (= L124), S125 (≠ T125), T241 (≠ G241), E362 (= E362), R374 (= R374)
- binding cobalt (ii) ion: D145 (≠ G145), H146 (≠ D146)
- binding flavin-adenine dinucleotide: F122 (= F122), L124 (= L124), S125 (≠ T125), G130 (= G130), S131 (= S131), W155 (≠ F155), S157 (≠ T157), K200 (= K200), L357 (≠ V357), Y361 (= Y361), E362 (= E362), T364 (= T364), E366 (≠ D366), L370 (≠ M370)
1ukwA Crystal structure of medium-chain acyl-coa dehydrogenase from thermus thermophilus hb8
39% identity, 99% coverage: 4:376/377 of query aligns to 5:376/379 of 1ukwA
- active site: L124 (= L124), S125 (≠ T125), T241 (≠ G241), E362 (= E362), R374 (= R374)
- binding flavin-adenine dinucleotide: F122 (= F122), L124 (= L124), S125 (≠ T125), G130 (= G130), S131 (= S131), W155 (≠ F155), S157 (≠ T157), L357 (≠ V357), Y361 (= Y361), E362 (= E362), T364 (= T364), E366 (≠ D366), L370 (≠ M370)
1bucA Three-dimensional structure of butyryl-coa dehydrogenase from megasphaera elsdenii (see paper)
40% identity, 98% coverage: 4:371/377 of query aligns to 5:376/383 of 1bucA
- active site: L128 (= L124), T129 (= T125), G246 (= G241), E367 (= E362)
- binding acetoacetyl-coenzyme a: L96 (≠ P92), F126 (= F122), G134 (= G130), T135 (≠ S131), T162 (= T157), N182 (≠ K177), H183 (≠ E178), F236 (≠ Y231), M240 (≠ L235), M241 (≠ S236), L243 (= L238), D244 (≠ E239), T317 (≠ L312), Y366 (= Y361), E367 (= E362), G368 (= G363)
- binding flavin-adenine dinucleotide: F126 (= F122), L128 (= L124), T129 (= T125), G134 (= G130), T135 (≠ S131), F160 (= F155), T162 (= T157), Y366 (= Y361), T369 (= T364), E371 (≠ D366), M375 (= M370)
Sites not aligning to the query:
Q06319 Acyl-CoA dehydrogenase, short-chain specific; Butyryl-CoA dehydrogenase; BCAD; SCAD; EC 1.3.8.1 from Megasphaera elsdenii (see paper)
40% identity, 98% coverage: 4:371/377 of query aligns to 5:376/383 of Q06319
- E367 (= E362) active site, Proton acceptor; mutation to Q: Loss of activity.
6fahD Molecular basis of the flavin-based electron-bifurcating caffeyl-coa reductase reaction (see paper)
37% identity, 98% coverage: 4:372/377 of query aligns to 3:372/379 of 6fahD
- active site: L124 (= L124), T125 (= T125), G241 (= G241)
- binding flavin-adenine dinucleotide: F122 (= F122), L124 (= L124), T125 (= T125), R152 (≠ E152), F155 (= F155), T157 (= T157), E198 (= E198), R267 (= R267), Q269 (≠ S269), F270 (= F270), I274 (≠ L274), F277 (≠ H277), Q335 (= Q335), I336 (≠ T336), G339 (= G339), Y361 (= Y361), T364 (= T364), Q366 (≠ D366)
Sites not aligning to the query:
Query Sequence
>WP_011842743.1 NCBI__GCF_000015985.1:WP_011842743.1
MSVLTDEQRLVQEMARTFAREVLAPGAAARAKAKAIEPAVLAQMGELGFFGMTVPEEMGG
VGADYMSYALALIEIAAGDGAVSTVMSVHNAPFNAILQRFASPAQRERVLRPAAQGAFIG
AFALTEAHAGSDASALRSRARRAGGDYVIDGEKVFITSGRLAGWAVLFARMEGSTGKEGI
TCFLTPTDTPGYEVVKVEDKLGQEASDTCALRFDSLRVPEALRIGAEGEGYRIALSSLET
GRIGIAAQSVGMAQAALEAAVAYARERTSFGRPLIEHQAVGFRLAEAKTRLEAARQMVLH
AARMKDTGQPCLTEAAMAKLFASEAAERIVSDAIQTFGGYGYSRDFPVERIYRDVRVCQI
YEGTSDIQKMLILRGMA
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory