SitesBLAST
Comparing WP_011880619.1 NCBI__GCF_000016205.1:WP_011880619.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 16 hits to proteins with known functional sites (download)
P25297 Inorganic phosphate transporter PHO84 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 6 papers)
28% identity, 34% coverage: 89:256/489 of query aligns to 117:302/587 of P25297
- C145 (≠ G117) mutation to S: No significant effect on transport activity; when associated with S-237, S-241, S-245, S-263, S-335, S-399, S-434, S-455, S-474, S-510 and S-519.
- F160 (≠ I132) mutation to C: Reduces phosphate binding, transport and signaling activities.
- R168 (= R142) mutation to A: Reduces transport activity. No significant effects on affinity for inorganic phosphate. No significant effects on growth rates.; mutation to C: Abolishes transport and signaling activities.; mutation to E: Reduces transport activity. Moderately reduces affinity for inorganic phosphate. No significant effects on growth rates.; mutation to Q: Reduces transport activity. Moderately reduces affinity for inorganic phosphate. Moderately reduces growth rates under low phosphate conditions. No significant effects on growth rates under high phosphate conditions.
- G172 (= G146) mutation to C: Abolishes transport and signaling activities.
- G174 (≠ S148) mutation to C: Abolishes transport and signaling activities.
- G176 (= G150) mutation to C: Abolishes transport and signaling activities.
- D178 (≠ E152) mutation D->E,N: Reduces transport activity. No significant effects on affinity for inorganic phosphate. No significant effects on signaling activities. No significant effects on growth rates.
- Y179 (= Y153) mutation to A: Significantly reduces transport activity. Causes pronounced increase in secreted phosphatase activity under high phosphate conditions. Reduces growth rates under low phosphate conditions. Slightly reduces signaling activity.; mutation to G: Abolishes transport activity. Causes pronounced increase in secreted phosphatase activity under high phosphate conditions. Reduces growth rates under low phosphate conditions. Abolishes signaling activity.; mutation Y->S,F: No significant effects on transport activity. No significant effects on growth rates under low phosphate conditions. Does not affect patterns of secreted phosphatase activities under low and high phosphate conditions. No significant effects on signaling activity.
- C237 (vs. gap) mutation to S: No significant effect on transport activity; when associated with S-145, S-241, S-245, S-263, S-335, S-399, S-434, S-455, S-474, S-510 and S-519.
- C241 (≠ L204) mutation to S: No significant effect on transport activity; when associated with S-145, S-237, S-245, S-263, S-335, S-399, S-434, S-455, S-474, S-510 and S-519.
- C245 (vs. gap) mutation to S: No significant effect on transport activity; when associated with S-145, S-237, S-241, S-263, S-335, S-399, S-434, S-455, S-474, S-510 and S-519.
- C263 (≠ G222) mutation to S: No significant effect on transport activity; when associated with S-145, S-237, S-241, S-245, S-335, S-399, S-434, S-455, S-474, S-510 and S-519.
- K298 (≠ Q252) modified: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); mutation to A: No significant effect on membrane localization under low phosphate conditions and internalization after phosphate addition. Strongly affects vacuolar sorting of the protein after internalization.
Sites not aligning to the query:
- 6 modified: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
- 304:327 mutation Missing: Increases transport activity. Has no significant effect on membrane localization under low phosphate conditions. Results in severely delayed internalization after phosphate addition.
- 335 C→S: No significant effect on transport activity; when associated with S-145, S-237, S-241, S-245, S-263, S-399, S-434, S-455, S-474, S-510 and S-519.
- 358 D→E: Abolishes transport activity. Causes pronounced increase in secreted phosphatase activity under high phosphate conditions. Moderately decreases signaling activities. Significantly reduces growth rates under low phosphate conditions. No significant effects on growth rates under high phosphate conditions.; D→N: Significantly reduces transport activity. No significant effects on affinity for inorganic phosphate. Causes pronounced increase in secreted phosphatase activity under high phosphate conditions. No significant effects on signaling activities. Significantly reduces growth rates under low phosphate conditions. No significant effects on growth rates under high phosphate conditions.
- 392 V→C: Reduces transport and signaling activities.
- 399 C→S: No significant effect on transport activity; when associated with S-145, S-237, S-241, S-245, S-263, S-335, S-434, S-455, S-474, S-510 and S-519.
- 408 V→C: Reduces signaling activity and enhances transport activity.
- 434 C→S: No significant effect on transport activity; when associated with S-145, S-237, S-241, S-245, S-263, S-335, S-399, S-455, S-474, S-510 and S-519.
- 455 C→S: No significant effect on transport activity; when associated with S-145, S-237, S-241, S-245, S-263, S-335, S-399, S-434, S-474, S-510 and S-519.
- 473 E→K: No significant effects on transport activity. No significant effects on affinity for inorganic phosphate. No significant effects on growth rates.; E→Q: No significant effects on transport activity. Reduces affinity for inorganic phosphate. No significant effects on growth rates.
- 474 C→S: No significant effect on transport activity; when associated with S-145, S-237, S-241, S-245, S-263, S-335, S-399, S-434, S-455, S-510 and S-519.
- 492 mutation K->A,Q: No significant effects on transport activity. Reduces affinity for inorganic phosphate. No significant effects on growth rates.; K→E: Reduces transport activity. Reduces affinity for inorganic phosphate. Significantly reduces growth rates under low phosphate conditions. No significant effects on growth rates under high phosphate conditions.
- 510 C→S: No significant effect on transport activity; when associated with S-145, S-237, S-241, S-245, S-263, S-335, S-399, S-434, S-455, S-474 and S-519.
- 519 C→S: No significant effect on transport activity; when associated with S-145, S-237, S-241, S-245, S-263, S-335, S-399, S-434, S-455, S-474 and S-510.
A0A0H2VG78 Glucose transporter GlcP; Glucose/H(+) symporter from Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200) (see paper)
24% identity, 62% coverage: 95:395/489 of query aligns to 63:375/446 of A0A0H2VG78
- R102 (= R142) mutation to A: Loss of transport activity.
- I105 (≠ Q145) mutation to S: Affects symport activity. May function as an uniporter.
- E122 (= E162) mutation to A: Loss of transport activity.
- Q137 (≠ E177) mutation to A: Loss of transport activity.
- Q250 (vs. gap) mutation to A: Loss of transport activity.
- Q251 (≠ N276) mutation to A: Loss of transport activity.
- N256 (≠ M281) mutation to A: Loss of transport activity.
- W357 (≠ P377) mutation to A: Loss of transport activity.
Sites not aligning to the query:
- 22 D→N: Affects symport activity. May function as an uniporter.
Q9Y7Q9 Probable metabolite transporter C2H8.02 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
26% identity, 34% coverage: 81:246/489 of query aligns to 90:262/583 of Q9Y7Q9
Sites not aligning to the query:
- 267 modified: Phosphoserine
- 269 modified: Phosphoserine
- 289 modified: Phosphoserine
- 290 modified: Phosphoserine
- 292 modified: Phosphoserine
- 330 modified: Phosphoserine
Q8NLB7 Gentisate transporter from Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / JCM 1318 / BCRC 11384 / CCUG 27702 / LMG 3730 / NBRC 12168 / NCIMB 10025 / NRRL B-2784 / 534) (see paper)
25% identity, 57% coverage: 47:327/489 of query aligns to 56:315/444 of Q8NLB7
- D57 (= D48) mutation to A: Loss of transport activity.; mutation to E: Retains 50% of its transport activity.
- R103 (= R100) mutation to A: Loss of transport activity.
- W309 (≠ H321) mutation to V: Loss of transport activity.
- D312 (= D324) mutation to A: Loss of transport activity.
- R313 (= R325) mutation to A: Loss of transport activity.
Sites not aligning to the query:
- 54 D→A: Loss of transport activity.; D→E: Retains 50% of its transport activity.
- 317 mutation I->H,Y: Loss of transport activity.
- 386 R→A: Loss of transport activity.
6m2lA Crystal structure of plasmodium falciparum hexose transporter pfht1 bound with c3361 (see paper)
22% identity, 52% coverage: 138:392/489 of query aligns to 99:381/447 of 6m2lA
Sites not aligning to the query:
Q7KWJ5 Hexose transporter 1; PfHT1 from Plasmodium falciparum (isolate 3D7) (see 5 papers)
23% identity, 53% coverage: 138:396/489 of query aligns to 130:431/504 of Q7KWJ5
- H168 (vs. gap) mutation to N: Reduces D-glucose and D-fructose transport activity.
- Q169 (vs. gap) binding alpha-D-glucose; binding beta-D-glucose; mutation to A: Abolishes D-glucose and D-fructose transport activity.; mutation to N: In one study, shown to abolish D-glucose and D-fructose transport activity. In another study, shown to abolish D-fructose transport with no significant effects on D-glucose uptake and affinity. Reduces susceptibility to inhibition by compound 3361.
- S302 (= S291) mutation to A: No significant effects on affinity for D-glucose and D-fructose.
- SGL 302:304 (≠ SAT 291:293) mutation to AGT: No significant effects on affinity for D-glucose and D-fructose.
- L304 (≠ T293) mutation to T: No significant effects on affinity for D-glucose and D-fructose.
- Q305 (≠ L294) binding alpha-D-glucose; binding beta-D-glucose; mutation to A: Reduces D-glucose and D-fructose transport activity.
- Q306 (≠ H295) binding alpha-D-glucose; mutation to A: Reduces D-glucose and D-fructose transport activity.
- I310 (vs. gap) mutation to A: Reduces D-glucose and D-fructose transport activity.
- N311 (vs. gap) binding alpha-D-glucose; binding beta-D-glucose; mutation to A: Reduces D-glucose and D-fructose transport activity.
- V314 (vs. gap) mutation to F: Reduces D-glucose and D-fructose transport activity.
- S315 (vs. gap) mutation to A: No significant effects on D-glucose and D-fructose transport activities. Reduces turnover number for D-glucose.; mutation to Y: Reduces D-glucose and D-fructose transport activity.
- N316 (vs. gap) mutation N->A,Y: Reduces D-glucose and D-fructose transport activity.
- S317 (vs. gap) mutation to A: Reduces D-glucose and D-fructose transport activity.
- N318 (= N297) mutation to A: Reduces D-glucose and D-fructose transport activity.
- E319 (= E298) mutation to A: No significant effects on D-glucose and D-fructose transport activities. Reduces turnover number for D-glucose.
- N341 (vs. gap) binding beta-D-glucose; mutation to A: Abolishes D-glucose and D-fructose transport activity.
- F403 (vs. gap) mutation to A: Reduces D-glucose and D-fructose transport activity.
- A404 (vs. gap) mutation to E: Modestly reduces D-glucose and D-fructose transport activities and affinities for these substrates.
- W412 (≠ P377) binding alpha-D-glucose; mutation to A: Reduces D-fructose transport with no significant effect on D-glucose uptake.
Sites not aligning to the query:
- 48 N→A: Reduces D-glucose and D-fructose transport activity.
- 51 K→A: Reduces D-glucose and D-fructose transport activity. Reduces susceptibility to inhibition by compound HTI-1. Reduces susceptibility to inhibition by compound HTI-1; when associated with A-447.; K→Q: Reduces D-glucose and D-fructose transport activity.
- 61 modified: Disulfide link with 70
- 70 modified: Disulfide link with 61
- 435 N→A: Reduces D-fructose transport with no significant effect on D-glucose uptake.
- 436 W→A: Reduces D-glucose and D-fructose transport activity.
- 439 A→N: Reduces D-glucose and D-fructose transport activity.
- 447 D→A: Reduces susceptibility to inhibition by compound HTI-1; when associated with A-51.
6rw3A The molecular basis for sugar import in malaria parasites. (see paper)
22% identity, 52% coverage: 138:392/489 of query aligns to 99:381/437 of 6rw3A
O42885 Putative inorganic phosphate transporter C8E4.01c from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
26% identity, 36% coverage: 81:256/489 of query aligns to 100:281/572 of O42885
Sites not aligning to the query:
- 12 modified: Phosphoserine
- 14 modified: Phosphoserine
- 292 modified: Phosphoserine
- 296 modified: Phosphoserine
8fvzA Pipt y150a
25% identity, 33% coverage: 44:206/489 of query aligns to 15:182/433 of 8fvzA
Sites not aligning to the query:
6m20B Crystal structure of plasmodium falciparum hexose transporter pfht1 bound with glucose (see paper)
23% identity, 53% coverage: 138:396/489 of query aligns to 109:410/478 of 6m20B
8bvtA Cryo-em structure of rat slc22a6 bound to probenecid (see paper)
32% identity, 26% coverage: 89:215/489 of query aligns to 138:252/508 of 8bvtA
Sites not aligning to the query:
8bw7A Cryo-em structure of rat slc22a6 bound to alpha-ketoglutaric acid (see paper)
32% identity, 26% coverage: 89:215/489 of query aligns to 129:243/497 of 8bw7A
Sites not aligning to the query:
8bvsA Cryo-em structure of rat slc22a6 bound to tenofovir (see paper)
32% identity, 26% coverage: 89:215/489 of query aligns to 129:243/502 of 8bvsA
Sites not aligning to the query:
8ttgA Nora single mutant - e222q at ph 7.5 (see paper)
24% identity, 33% coverage: 75:233/489 of query aligns to 38:180/374 of 8ttgA
Sites not aligning to the query:
Q09852 Putative inorganic phosphate transporter C23D3.12 from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
26% identity, 37% coverage: 81:261/489 of query aligns to 95:289/559 of Q09852
Sites not aligning to the query:
- 297 modified: Phosphoserine
- 299 modified: Phosphoserine
Q8VC69 Solute carrier family 22 member 6; Kidney-specific transport protein; Novel kidney transcript; mNKT; Organic anion transporter 1; mOAT1; Renal organic anion transporter 1; mROAT1 from Mus musculus (Mouse) (see 2 papers)
30% identity, 26% coverage: 89:215/489 of query aligns to 141:255/545 of Q8VC69
- C183 (≠ G131) mutation to A: Decreased cell surface expression level and PAH transport activity. Complete loss of PAH transport activity; when associated with A-49; A-78; A-99; A-122; A-172; A-200; A-362; A-335; A-379; A-402; A-427 and A-434.
Sites not aligning to the query:
- 39 N→Q: Complete loss of PAH transport activity.
- 49 C→A: Decreased cell surface expression level and PAH transport activity. Complete loss of PAH transport activity; when associated with A-78; A-99; A-122; A-172; A-183; A-200; A-362; A-335; A-379; A-402; A-427 and A-434.
- 56 modified: carbohydrate, N-linked (GlcNAc...) asparagine
- 86 modified: carbohydrate, N-linked (GlcNAc...) asparagine
- 91 modified: carbohydrate, N-linked (GlcNAc...) asparagine
- 107 modified: carbohydrate, N-linked (GlcNAc...) asparagine
- 122 C→A: Decreased cell surface expression level and PAH transport activity. Complete loss of PAH transport activity; when associated with A-49; A-78; A-99; A-172; A-183; A-200; A-362; A-335; A-379; A-402; A-427 and A-434.
- 434 C→A: Decreased cell surface expression level and PAH transport activity. 80% decrease of PAH transport activity; when associated with A-49; A-122 and A-183. Complete loss of PAH transport activity; when associated with A-49; A-78; A-99; A-122; A-172; A-183; A-200; A-362; A-335; A-379; A-402 and A-427.
Query Sequence
>WP_011880619.1 NCBI__GCF_000016205.1:WP_011880619.1
MSSPHAHSAKTRSSRQALKLDDITIVDRAILKRAVGAMAFGNAMEWFDFGVYSYIAVTLG
KVFFPSSSPSAQLLATFGTFAAAFVVRPLGGMVFGPLGDRIGRQRVLAATMIMMAVGTFA
IGLIPSYASIGIMAPVLLLVARLVQGFSTGGEYGGAATFIAEFSTDKRRGFMGSFLEFGT
LIGYTLGAATVTLLTATLSHDALLSWGWRVPFFIAGPLGLVGLYIRIKLEETPAFKKEAL
AREADERARPKQSFGTLLVEQWRPLLQCVGLVLIFNVTDYMALSYLPNYLSATLHFNETH
GLFMVLIVMLLMMPMTLYAGHLSDRIGRKPVMMFGCVGLLVLSVPALMLIRTGGMLPVFG
GMLIYGTLLSTFTGVMPSALPALFPTRIRYGALAIGFNVSVSLFGGTTPLVTAWLVDRTG
DLMMPAYYLMGASFIGIVSVLALRESARRPLPGSTPCVGSRAEAQELIRRGAGEVRGRER
KLTPIGERA
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory