SitesBLAST
Comparing WP_011883238.1 NCBI__GCF_000016205.1:WP_011883238.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
5wjsA Crystal structure of oxidoreductase (short chain dehydrogenase/reductase family) from burkholderia thailandensis complexed with nadh
86% identity, 98% coverage: 6:265/265 of query aligns to 2:258/258 of 5wjsA
- active site: G27 (= G31), S152 (= S159), Y162 (= Y169), Y165 (= Y172), K169 (= K176)
- binding 1,4-dihydronicotinamide adenine dinucleotide: G23 (= G27), T26 (= T30), I28 (= I32), D47 (= D51), L48 (= L52), D73 (= D80), L74 (= L81), N100 (= N107), A102 (= A109), L150 (= L157), G151 (= G158), S152 (= S159), K169 (= K176), P195 (= P202), G196 (= G203), W197 (= W204), V198 (= V205), K202 (= K209)
7wwxA Crystal structure of herbaspirillum huttiense l-arabinose 1- dehydrogenase (NAD bound form) (see paper)
56% identity, 96% coverage: 11:264/265 of query aligns to 2:253/254 of 7wwxA
- binding nicotinamide-adenine-dinucleotide: G18 (= G27), T21 (= T30), I23 (= I32), D42 (= D51), I43 (≠ L52), C68 (= C79), D69 (= D80), L70 (= L81), N96 (= N107), A98 (= A109), F146 (≠ L157), S147 (≠ G158), S148 (= S159), Y161 (= Y172), K165 (= K176), P191 (= P202), G192 (= G203), W193 (= W204), V194 (= V205), R198 (≠ K209)
4jroC Crystal structure of 3-oxoacyl-[acyl-carrier protein]reductase (fabg) from listeria monocytogenes in complex with NADP+
35% identity, 94% coverage: 17:264/265 of query aligns to 2:245/247 of 4jroC
- active site: G16 (= G31), S142 (= S159), Q152 (≠ Y169), Y155 (= Y172), K159 (= K176)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G12 (= G27), S14 (≠ A29), R15 (≠ T30), G16 (= G31), I17 (= I32), N35 (≠ V50), Y36 (≠ D51), N37 (≠ L52), G38 (≠ D53), S39 (≠ A54), N63 (≠ F76), V64 (= V77), N90 (= N107), A91 (= A108), I93 (≠ N110), I113 (≠ V130), S142 (= S159), Y155 (= Y172), K159 (= K176), P185 (= P202), I188 (≠ V205), T190 (= T207)
F1SWA0 Zerumbone synthase; EC 1.1.1.326 from Zingiber zerumbet (Shampoo ginger) (Amomum zerumbet) (see paper)
33% identity, 94% coverage: 18:265/265 of query aligns to 3:257/267 of F1SWA0
- S142 (= S159) mutation to A: Strong reduction in oxidoreductase activity toward 8-hydroxy-alpha-humulene and borneol.
- S144 (= S161) mutation to A: Increased oxidoreductase activity toward 8-hydroxy-alpha-humulene and borneol.
- Y155 (= Y172) mutation to A: Strong reduction in oxidoreductase activity toward 8-hydroxy-alpha-humulene and borneol.
- K159 (= K176) mutation to A: Abolishes all oxidoreductase activity.
Q5P5I4 (S)-1-Phenylethanol dehydrogenase; EC 1.1.1.311 from Aromatoleum aromaticum (strain EbN1) (Azoarcus sp. (strain EbN1)) (see 2 papers)
36% identity, 93% coverage: 18:263/265 of query aligns to 5:245/249 of Q5P5I4
- NGI 17:19 (≠ TGI 30:32) binding NAD(+)
- D38 (= D51) binding NAD(+)
- CDV 61:63 (≠ CDL 79:81) binding NAD(+)
- N89 (= N107) binding NAD(+)
- Y93 (≠ D111) binding NAD(+)
- K158 (= K176) binding NAD(+)
- PSLV 184:187 (≠ PGWV 202:205) binding NAD(+)
- T191 (≠ K209) binding NAD(+)
Sites not aligning to the query:
- 1 modified: Initiator methionine, Removed
2ewmB Crystal structure of the (s)-specific 1-phenylethanol dehydrogenase of the denitrifying bacterium strain ebn1 (see paper)
36% identity, 93% coverage: 18:263/265 of query aligns to 3:243/247 of 2ewmB
- active site: G16 (= G31), S139 (= S159), Y149 (= Y169), Y152 (= Y172), K156 (= K176)
- binding nicotinamide-adenine-dinucleotide: G12 (= G27), N15 (≠ T30), G16 (= G31), I17 (= I32), D36 (= D51), L37 (= L52), C59 (= C79), D60 (= D80), V61 (≠ L81), N87 (= N107), S139 (= S159), Y152 (= Y172), K156 (= K176), P182 (= P202), S183 (≠ G203), L184 (≠ W204), V185 (= V205), T189 (≠ K209)
7pcsB Structure of the heterotetrameric sdr family member bbscd (see paper)
35% identity, 93% coverage: 18:263/265 of query aligns to 2:241/247 of 7pcsB
- binding nicotinamide-adenine-dinucleotide: G11 (= G27), M16 (≠ I32), D35 (= D51), I36 (≠ L52), I62 (≠ L81), N88 (= N107), G90 (≠ A109), I138 (≠ L157), S140 (= S159), Y152 (= Y172), K156 (= K176), I185 (≠ V205)
Q9KJF1 (2S)-[(R)-hydroxy(phenyl)methyl]succinyl-CoA dehydrogenase subunit BbsD; (S,R)-2-(alpha-hydroxybenzyl)succinyl-CoA dehydrogenase subunit BbsD; EC 1.1.1.429 from Thauera aromatica (see 2 papers)
35% identity, 93% coverage: 18:263/265 of query aligns to 3:242/248 of Q9KJF1
- S15 (≠ T30) binding NAD(+)
- D36 (= D51) binding NAD(+)
- D62 (= D80) binding NAD(+)
- I63 (≠ L81) binding NAD(+)
- N89 (= N107) binding NAD(+)
- Y153 (= Y172) binding NAD(+)
- K157 (= K176) binding NAD(+)
Sites not aligning to the query:
- 1 modified: Initiator methionine, Removed
7krmC Putative fabg bound to nadh from acinetobacter baumannii
36% identity, 93% coverage: 18:264/265 of query aligns to 3:241/244 of 7krmC
- active site: G18 (= G31), S140 (= S159), Y155 (= Y172)
- binding nicotinamide-adenine-dinucleotide: G12 (= G27), S15 (≠ T30), G18 (= G31), I19 (= I32), D38 (= D51), L39 (= L52), A60 (≠ C79), N61 (≠ D80), V62 (≠ L81), N88 (= N107), V111 (= V130), S140 (= S159), Y155 (= Y172), K159 (= K176), I188 (≠ V205), T190 (= T207)
4nbuB Crystal structure of fabg from bacillus sp (see paper)
32% identity, 93% coverage: 18:263/265 of query aligns to 5:241/244 of 4nbuB
- active site: G18 (= G31), N111 (= N131), S139 (= S159), Q149 (≠ Y169), Y152 (= Y172), K156 (= K176)
- binding acetoacetyl-coenzyme a: D93 (≠ R113), K98 (≠ D118), S139 (= S159), N146 (= N166), V147 (≠ G167), Q149 (≠ Y169), Y152 (= Y172), F184 (≠ W204), M189 (≠ K209), K200 (≠ A218)
- binding 1,4-dihydronicotinamide adenine dinucleotide: G14 (= G27), N17 (≠ T30), G18 (= G31), I19 (= I32), D38 (= D51), F39 (≠ L52), V59 (≠ C79), D60 (= D80), V61 (≠ L81), N87 (= N107), A88 (= A108), G89 (≠ A109), I90 (≠ N110), T137 (≠ L157), S139 (= S159), Y152 (= Y172), K156 (= K176), P182 (= P202), F184 (≠ W204), T185 (≠ V205), T187 (= T207), M189 (≠ K209)
7tzpG Crystal structure of putataive short-chain dehydrogenase/reductase (fabg) from klebsiella pneumoniae subsp. Pneumoniae ntuh-k2044 in complex with nadh (see paper)
33% identity, 93% coverage: 17:263/265 of query aligns to 5:244/247 of 7tzpG
- binding 1,4-dihydronicotinamide adenine dinucleotide: G15 (= G27), R18 (≠ T30), G19 (= G31), I20 (= I32), D39 (= D51), R40 (≠ L52), C63 (= C79), I65 (≠ L81), N91 (= N107), G93 (≠ A109), I94 (≠ N110), V114 (= V130), Y155 (= Y172), K159 (= K176), I188 (≠ V205), T190 (= T207), T193 (≠ Q210)
6zzsD Crystal structure of (r)-3-hydroxybutyrate dehydrogenase from acinetobacter baumannii complexed with NAD+ and 3-oxovalerate (see paper)
33% identity, 92% coverage: 21:264/265 of query aligns to 8:258/261 of 6zzsD
- active site: G18 (= G31), S143 (= S159), Y156 (= Y172)
- binding nicotinamide-adenine-dinucleotide: G14 (= G27), S17 (≠ T30), I19 (= I32), D38 (= D51), M39 (≠ L52), D64 (= D80), V65 (≠ L81), N91 (= N107), A92 (= A108), G93 (≠ A109), M141 (≠ L157), A142 (≠ G158), S143 (= S159), Y156 (= Y172), K160 (= K176), P186 (= P202), G187 (= G203), V189 (= V205), T191 (= T207), L193 (vs. gap)
- binding 3-oxidanylidenepentanoic acid: Q95 (≠ D111), S143 (= S159), N145 (≠ S161), K153 (≠ Y169), Y156 (= Y172), Q197 (vs. gap)
6zzqA Crystal structure of (r)-3-hydroxybutyrate dehydrogenase from acinetobacter baumannii complexed with NAD+ and acetoacetate (see paper)
33% identity, 92% coverage: 21:264/265 of query aligns to 7:257/260 of 6zzqA
- active site: G17 (= G31), S142 (= S159), Y155 (= Y172)
- binding acetoacetic acid: Q94 (≠ D111), S142 (= S159), K152 (≠ Y169), Y155 (= Y172), Q196 (vs. gap)
- binding nicotinamide-adenine-dinucleotide: G13 (= G27), S16 (≠ T30), G17 (= G31), I18 (= I32), D37 (= D51), M38 (≠ L52), D63 (= D80), V64 (≠ L81), N90 (= N107), A91 (= A108), G92 (≠ A109), M140 (≠ L157), A141 (≠ G158), S142 (= S159), Y155 (= Y172), K159 (= K176), Y187 (≠ W204), V188 (= V205), T190 (= T207)
7do7A Crystal structure of azotobacter vinelandii l-rhamnose 1- dehydrogenase(NAD and l-rhamnose bound-form) (see paper)
34% identity, 93% coverage: 18:264/265 of query aligns to 3:251/256 of 7do7A
- active site: G16 (= G31), S146 (= S159), Y159 (= Y172)
- binding nicotinamide-adenine-dinucleotide: G12 (= G27), R15 (≠ T30), G16 (= G31), I17 (= I32), S37 (≠ L52), D66 (= D80), A67 (≠ L81), N93 (= N107), A94 (= A108), G95 (≠ A109), I96 (≠ N110), V144 (≠ L157), S145 (≠ G158), S146 (= S159), Y159 (= Y172), K163 (= K176), P189 (= P202), G190 (= G203), I192 (≠ V205), T194 (= T207), I196 (≠ K209)
- binding beta-L-rhamnopyranose: F99 (≠ R113), S146 (= S159), S148 (= S161), Q156 (≠ Y169), Y159 (= Y172), N197 (≠ Q210), D235 (= D248), M236 (≠ D249), R238 (= R251)
7b81A Crystal structure of azotobacter vinelandii l-rhamnose 1-dehydrogenase (NAD bound-form) (see paper)
34% identity, 93% coverage: 18:264/265 of query aligns to 3:251/256 of 7b81A
- active site: G16 (= G31), S146 (= S159), Y159 (= Y172)
- binding nicotinamide-adenine-dinucleotide: G12 (= G27), S14 (≠ A29), R15 (≠ T30), I17 (= I32), D66 (= D80), A67 (≠ L81), N93 (= N107), A94 (= A108), G95 (≠ A109), I96 (≠ N110), T116 (≠ V130), V144 (≠ L157), S146 (= S159), Y159 (= Y172), K163 (= K176), P189 (= P202), G190 (= G203), I192 (≠ V205), T194 (= T207), I196 (≠ K209)
3o4rA Crystal structure of human dehydrogenase/reductase (sdr family) member 4 (dhrs4)
32% identity, 95% coverage: 13:263/265 of query aligns to 1:249/254 of 3o4rA
- active site: G19 (= G31), S145 (= S159), F155 (≠ Y169), Y158 (= Y172), K162 (= K176), K203 (≠ D217)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: A15 (≠ G27), T17 (≠ A29), D18 (≠ T30), G19 (= G31), I20 (= I32), S39 (≠ D51), R40 (≠ L52), K41 (≠ D53), N44 (≠ A56), H65 (≠ V77), V66 (≠ A78), N92 (= N107), A94 (= A109), S145 (= S159), Y158 (= Y172), K162 (= K176), P188 (= P202), G189 (= G203), L190 (≠ W204), I191 (≠ V205), T193 (= T207), F195 (≠ K209), S196 (≠ Q210)
1vl8B Crystal structure of gluconate 5-dehydrogenase (tm0441) from thermotoga maritima at 2.07 a resolution
27% identity, 93% coverage: 18:264/265 of query aligns to 4:249/252 of 1vl8B
- active site: G17 (= G31), S143 (= S159), I154 (vs. gap), Y157 (= Y172), K161 (= K176)
- binding nadp nicotinamide-adenine-dinucleotide phosphate: G13 (= G27), R16 (≠ T30), G17 (= G31), L18 (≠ I32), S37 (≠ D51), R38 (≠ L52), C63 (= C79), D64 (= D80), V65 (≠ L81), A91 (≠ N107), A92 (= A108), G93 (≠ A109), I94 (≠ N110), V114 (= V130), I141 (≠ L157), S143 (= S159), Y157 (= Y172), K161 (= K176), P187 (= P202), G188 (= G203), Y190 (≠ V205), T192 (= T207), M194 (≠ K209), T195 (≠ Q210)
Q9BTZ2 Dehydrogenase/reductase SDR family member 4; NADPH-dependent carbonyl reductase; CR; NADPH-dependent retinol dehydrogenase/reductase; NRDR; humNRDR; Peroxisomal short-chain alcohol dehydrogenase; PSCD; SCAD-SRL; Short chain dehydrogenase/reductase family 25C member 2; Protein SDR25C2; Short-chain dehydrogenase/reductase family member 4; EC 1.1.1.184 from Homo sapiens (Human) (see 2 papers)
32% identity, 94% coverage: 14:263/265 of query aligns to 26:273/278 of Q9BTZ2
- S176 (≠ N166) Responsible for the stereoselective reduction of 3-ketosteroids into 3beta-hydroxysteroids and benzil into R-benzoin; mutation to F: Decreased reduction activity for benzil, isatin and retinal and increased activity for 5beta-Pregnane-3,20-dione and 5beta-Dihydrotestosterone. No change of stereoselectivity in 3-ketosteroids reduction and no change in 3beta-hydroxysteroid oxidation. Decreased reduction activity for isatin and increased activity for 5beta-Pregnane-3,20-dione, 5beta-Dihydrotestosterone, benzil and retinal; when associated with L-179. Change in stereoselective activity by the reduction of 5beta-Pregnane-3,20-dione predominantly to the 3alpha-hydroxysteroid; when associated with L-179. Switch from 3beta-hydroxysteroid to 3alpha-hydroxysteroid oxidation; when associated with L-179. Loss of cold catalytic inactivation; when associated with L-179 and N-195. Increased reduction activity for renital and oxidation activity for retinol; when associated with L-179 and N-195.
- F179 (≠ Y169) Responsible for the stereoselective reduction of 3-ketosteroids into 3beta-hydroxysteroids and benzil into R-benzoin; mutation to L: Decreased reduction activity for isatin and increased activity for 5beta-Pregnane-3,20-dione, 5beta-Dihydrotestosterone, benzil and retinal; when associated with F-176. Change in stereoselective activity by the reduction of 5beta-Pregnane-3,20-dione predominantly to the 3alpha-hydroxysteroid; when associated with F-176. Switch from 3beta-hydroxysteroid to 3alpha-hydroxysteroid oxidation; when associated with F-176. Loss of cold catalytic inactivation; when associated with F-176 and N-195. Increased reduction activity for renital and oxidation activity for retinol; when associated with F-176 and N-195.
- T195 (≠ G185) mutation to N: Loss of cold catalytic inactivation. Loss of cold catalytic inactivation; when associated with F-176 and L-179. Switch in stereoselective activity from 3beta-hydroxysteroid to 3alpha-hydroxysteroid oxidation; when associated with F-176 and L-179. Increased reduction activity for renital and oxidation activity for retinol; when associated with F-176 and L-179.
Q9C826 Xanthoxin dehydrogenase; Protein ABSCISIC ACID DEFICIENT 2; Protein GLUCOSE INSENSITIVE 1; Protein IMPAIRED SUCROSE INDUCTION 4; Protein SALOBRENO 3; Protein SALT RESISTANT 1; Protein SUGAR INSENSITIVE 4; Short-chain alcohol dehydrogenase ABA2; Short-chain dehydrogenase reductase 1; AtSDR1; Xanthoxin oxidase; EC 1.1.1.288 from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
31% identity, 100% coverage: 1:265/265 of query aligns to 1:275/285 of Q9C826
- G28 (= G28) mutation to R: In aba2-12/sre1-2; reduced absicic acid synthesis.
- A45 (= A45) mutation to V: In aba2-4/sis4-2; reduced absicic acid synthesis.
- R145 (≠ D144) mutation to C: In gin1-2; reduced absicic acid synthesis.
- G162 (≠ S161) mutation to R: In aba2-3/sis4-1; reduced absicic acid synthesis.
- S176 (≠ A175) mutation to F: In aba2-13/san3-1; reduced absicic acid synthesis.
- A236 (= A225) mutation to V: In isi4; reduced absicic acid synthesis.
- S264 (≠ T254) mutation to N: In aba2-1; reduced absicic acid synthesis.
8cxaA Crystal structure of 3-oxoacyl-[acyl-carrier-protein] reductase from mycobacterium smegmatis with bound NAD
30% identity, 93% coverage: 18:263/265 of query aligns to 3:247/251 of 8cxaA
- binding nicotinamide-adenine-dinucleotide: G12 (= G27), Q15 (≠ T30), G16 (= G31), I17 (= I32), D36 (= D51), V63 (≠ L81), N89 (= N107), A91 (= A109), S94 (vs. gap), I142 (≠ L157), S143 (≠ G158), S144 (= S159), Y157 (= Y172), K161 (= K176), P187 (= P202), H188 (≠ G203), I190 (≠ V205), I194 (≠ K209)
Query Sequence
>WP_011883238.1 NCBI__GCF_000016205.1:WP_011883238.1
MTLDTSAQHARYARYPSLADRAVLITGGATGIGASFVEHFARQGARVAFVDLDAQAGAAL
AERLVGEPEVRHAPLFVACDLTDIDALRGTIDAIRARLGAIDVLVNNAANDARHAIADVT
PASFDAGIAVNLRHQFFAAQAVIDDMKRQGGGAIINLGSISWMLKNGGYPVYVMAKAAVQ
GLTRGLARDLGPFGIRVNSLVPGWVMTDKQRRLWLDDAGRAAIKAGQCIDAELLPDDLAR
MALFLAADDSRMITAQDVVVDGGWA
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory