Comparing WP_011906806.1 NCBI__GCF_000013325.1:WP_011906806.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
3dv0D Snapshots of catalysis in the e1 subunit of the pyruvate dehydrogenase multi-enzyme complex (see paper)
41% identity, 99% coverage: 2:336/337 of query aligns to 1:324/324 of 3dv0D
3dv0B Snapshots of catalysis in the e1 subunit of the pyruvate dehydrogenase multi-enzyme complex (see paper)
41% identity, 99% coverage: 2:336/337 of query aligns to 1:324/324 of 3dv0B
3dufD Snapshots of catalysis in the e1 subunit of the pyruvate dehydrogenase multi-enzyme complex (see paper)
41% identity, 99% coverage: 2:336/337 of query aligns to 1:324/324 of 3dufD
1w85B The crystal structure of pyruvate dehydrogenase e1 bound to the peripheral subunit binding domain of e2 (see paper)
41% identity, 99% coverage: 2:336/337 of query aligns to 1:324/324 of 1w85B
Q5SLR3 2-oxoisovalerate dehydrogenase subunit beta; Branched-chain alpha-keto acid dehydrogenase E1 component beta chain; BCKDH E1-beta; EC 1.2.4.4 from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) (see paper)
43% identity, 100% coverage: 1:336/337 of query aligns to 1:324/324 of Q5SLR3
1umdD Branched-chain 2-oxo acid dehydrogenase (e1) from thermus thermophilus hb8 with 4-methyl-2-oxopentanoate as an intermediate (see paper)
43% identity, 99% coverage: 2:336/337 of query aligns to 1:323/323 of 1umdD
1umcD Branched-chain 2-oxo acid dehydrogenase (e1) from thermus thermophilus hb8 with 4-methylpentanoate (see paper)
43% identity, 99% coverage: 2:336/337 of query aligns to 1:323/323 of 1umcD
1umbD Branched-chain 2-oxo acid dehydrogenase (e1) from thermus thermophilus hb8 in holo-form (see paper)
43% identity, 99% coverage: 2:336/337 of query aligns to 1:323/323 of 1umbD
P11177 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial; PDHE1-B; EC 1.2.4.1 from Homo sapiens (Human) (see 6 papers)
40% identity, 99% coverage: 3:334/337 of query aligns to 32:357/359 of P11177
Sites not aligning to the query:
6cerD Human pyruvate dehydrogenase complex e1 component v138m mutation (see paper)
40% identity, 99% coverage: 3:334/337 of query aligns to 4:329/331 of 6cerD
6cfoB Human pyruvate dehydrogenase e1 component complex with covalent tdp adduct acetyl phosphinate (see paper)
40% identity, 99% coverage: 3:334/337 of query aligns to 3:328/330 of 6cfoB
1qs0B Crystal structure of pseudomonas putida 2-oxoisovalerate dehydrogenase (branched-chain alpha-keto acid dehydrogenase, e1b) (see paper)
37% identity, 94% coverage: 18:334/337 of query aligns to 19:336/338 of 1qs0B
1dtwB Human branched-chain alpha-keto acid dehydrogenase (see paper)
39% identity, 99% coverage: 3:336/337 of query aligns to 4:326/326 of 1dtwB
2j9fD Human branched-chain alpha-ketoacid dehydrogenase-decarboxylase e1b (see paper)
39% identity, 99% coverage: 3:336/337 of query aligns to 7:329/329 of 2j9fD
P21953 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial; Branched-chain alpha-keto acid dehydrogenase E1 component beta chain; BCKDE1B; BCKDH E1-beta; EC 1.2.4.4 from Homo sapiens (Human) (see 2 papers)
39% identity, 99% coverage: 3:336/337 of query aligns to 70:392/392 of P21953
6yakDDD C-terminal component of the split chain transketolase (see paper)
27% identity, 72% coverage: 49:290/337 of query aligns to 33:265/311 of 6yakDDD
Sites not aligning to the query:
8v9iA 1-deoxy-D-xylulose-5-phosphate synthase (see paper)
28% identity, 63% coverage: 55:266/337 of query aligns to 324:518/595 of 8v9iA
Sites not aligning to the query:
6ouvA 1-deoxy-d-xylulose 5-phosphate synthase (dxps) from deinococcus radiodurans with methylacetylphosphonate (map) bound (see paper)
28% identity, 63% coverage: 55:266/337 of query aligns to 324:518/595 of 6ouvA
Sites not aligning to the query:
Q9RUB5 1-deoxy-D-xylulose-5-phosphate synthase; 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS; EC 2.2.1.7 from Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / CCUG 27074 / LMG 4051 / NBRC 15346 / NCIMB 9279 / VKM B-1422 / R1) (see paper)
28% identity, 63% coverage: 55:266/337 of query aligns to 358:552/629 of Q9RUB5
Sites not aligning to the query:
2o1xA 1-deoxy-d-xylulose 5-phosphate synthase (dxs) from deinococcus radiodurans (see paper)
28% identity, 63% coverage: 55:266/337 of query aligns to 309:503/578 of 2o1xA
Sites not aligning to the query:
>WP_011906806.1 NCBI__GCF_000013325.1:WP_011906806.1
MAKMMYRDAVVSTIAEEMERDENVVMLGEDIVGGMGTPGGPEAIGGIWSTSTGLFGKFGA
DRVIDTPISESAIMGAAAGLALSGKRPIAELMFADFIGVSLDQIWNQLAKFRYMFGGKTK
CPAVIRMAYGAGYNAAAQHSQAVHQILTGMPGLKVVMPTTPADVKGLLRTAIRDDDPVIF
LEHKALYGVSGEVPDDPDFMIPFGHARLSRAGQDVTIVSTGLLLGFCEAVADKLAAEGIG
CDVIDLRTTSPIDEETILDSVEVTGRLVVVDEAPPRCSLASDICATVAEKGFAALKAPPQ
AVNPPHTPIPFARELESAYLPSVDKIEAAVRKVLAYR
Or try a new SitesBLAST search
SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory