SitesBLAST
Comparing WP_011938379.1 NCBI__GCF_000016745.1:WP_011938379.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
3slhD 1.70 angstrom resolution structure of 3-phosphoshikimate 1- carboxyvinyltransferase (aroa) from coxiella burnetii in complex with shikimate-3-phosphate and glyphosate
51% identity, 99% coverage: 4:425/428 of query aligns to 5:427/440 of 3slhD
- active site: K23 (= K22), S24 (= S23), D50 (= D49), N95 (= N92), R125 (= R122), D317 (= D314), E345 (= E342), H388 (= H386), R389 (= R387), T415 (= T413)
- binding glyphosate: K23 (= K22), G97 (= G94), T98 (= T95), R125 (= R122), Q171 (= Q169), D317 (= D314), E345 (= E342), R348 (= R345), H388 (= H386), R389 (= R387)
- binding shikimate-3-phosphate: S24 (= S23), R28 (= R27), S169 (= S167), Q171 (= Q169), R196 (= R194), D317 (= D314), K344 (= K341)
- binding (3r,4s,5r)-3,4,5-trihydroxycyclohex-1-ene-1-carboxylic acid: S24 (= S23), R28 (= R27), T98 (= T95), Q171 (= Q169), R196 (= R194), D317 (= D314), K344 (= K341)
Q83E11 3-phosphoshikimate 1-carboxyvinyltransferase; 5-enolpyruvylshikimate-3-phosphate synthase; EPSP synthase; EPSPS; EC 2.5.1.19 from Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
51% identity, 99% coverage: 4:425/428 of query aligns to 3:425/438 of Q83E11
- K21 (= K22) binding phosphoenolpyruvate
- S22 (= S23) binding 3-phosphoshikimate
- R26 (= R27) binding 3-phosphoshikimate
- NSGT 93:96 (= NSGT 92:95) Phosphoenolpyruvate
- G95 (= G94) binding phosphoenolpyruvate
- T96 (= T95) binding phosphoenolpyruvate
- R123 (= R122) binding phosphoenolpyruvate
- S167 (= S167) binding 3-phosphoshikimate
- A168 (= A168) binding 3-phosphoshikimate
- Q169 (= Q169) binding 3-phosphoshikimate; binding phosphoenolpyruvate
- D315 (= D314) binding 3-phosphoshikimate
- K342 (= K341) binding 3-phosphoshikimate
- R346 (= R345) binding phosphoenolpyruvate
- R387 (= R387) binding phosphoenolpyruvate
4egrA 2.50 angstrom resolution structure of 3-phosphoshikimate 1- carboxyvinyltransferase (aroa) from coxiella burnetii in complex with phosphoenolpyruvate
51% identity, 99% coverage: 4:425/428 of query aligns to 5:423/434 of 4egrA
- active site: K23 (= K22), S24 (= S23), D50 (= D49), N95 (= N92), R125 (= R122), D313 (= D314), E341 (= E342), H384 (= H386), R385 (= R387), T411 (= T413)
- binding phosphoenolpyruvate: K23 (= K22), G97 (= G94), T98 (= T95), R125 (= R122), D313 (= D314), E341 (= E342), R344 (= R345), R385 (= R387)
Q9S400 3-phosphoshikimate 1-carboxyvinyltransferase; 5-enolpyruvylshikimate-3-phosphate synthase; EPSP synthase; EPSPS; EC 2.5.1.19 from Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) (see paper)
47% identity, 97% coverage: 10:426/428 of query aligns to 8:425/427 of Q9S400
- S21 (= S23) binding 3-phosphoshikimate
- R25 (= R27) binding 3-phosphoshikimate
- S166 (= S167) binding 3-phosphoshikimate
- A167 (= A168) binding 3-phosphoshikimate
- Q168 (= Q169) binding 3-phosphoshikimate
- D312 (= D314) binding 3-phosphoshikimate
- K339 (= K341) binding 3-phosphoshikimate
1rf6A Structural studies of streptococcus pneumoniae epsp synthase in s3p- glp bound state (see paper)
46% identity, 97% coverage: 10:426/428 of query aligns to 8:425/427 of 1rf6A
- active site: K20 (= K22), S21 (= S23), D47 (= D49), N90 (= N92), D115 (≠ Q117), R120 (= R122), D312 (= D314), E340 (= E342), H384 (= H386), R385 (= R387), T412 (= T413)
- binding glyphosate: K20 (= K22), G92 (= G94), T93 (= T95), R120 (= R122), Q168 (= Q169), D312 (= D314), E340 (= E342), R343 (= R345), H384 (= H386), R385 (= R387)
- binding shikimate-3-phosphate: S21 (= S23), R25 (= R27), S166 (= S167), Q168 (= Q169), R193 (= R194), I311 (= I313), D312 (= D314), K339 (= K341)
1rf4A Structural studies of streptococcus pneumoniae epsp synthase, tetrahedral intermediate bound state (see paper)
46% identity, 97% coverage: 10:426/428 of query aligns to 8:425/427 of 1rf4A
- active site: K20 (= K22), S21 (= S23), D47 (= D49), N90 (= N92), D115 (≠ Q117), R120 (= R122), D312 (= D314), E340 (= E342), H384 (= H386), R385 (= R387), T412 (= T413)
- binding (3r,4s,5r)-5-{[(1r)-1-carboxy-2-fluoro-1-(phosphonooxy)ethyl]oxy}-4-hydroxy-3-(phosphonooxy)cyclohex-1-ene-1-carboxylic acid: K20 (= K22), S21 (= S23), R25 (= R27), G92 (= G94), T93 (= T95), R120 (= R122), S166 (= S167), A167 (= A168), Q168 (= Q169), R193 (= R194), D312 (= D314), K339 (= K341), E340 (= E342), R343 (= R345), H384 (= H386), R385 (= R387)
Q9R4E4 3-phosphoshikimate 1-carboxyvinyltransferase; 5-enolpyruvylshikimate-3-phosphate synthase; EPSP synthase; EPSPS; CP4 EPSP synthase; EC 2.5.1.19 from Agrobacterium sp. (strain CP4) (see paper)
47% identity, 98% coverage: 5:422/428 of query aligns to 11:440/455 of Q9R4E4
- S29 (= S23) binding 3-phosphoshikimate
- R33 (= R27) binding 3-phosphoshikimate
- A100 (≠ G94) mutation to G: Confers sensitivity to glyphosate allowing glyphosate to bind in its extended, inhibitory conformation.
- S173 (= S167) binding 3-phosphoshikimate
- A174 (= A168) binding 3-phosphoshikimate
- Q175 (= Q169) binding 3-phosphoshikimate
- D326 (= D314) binding 3-phosphoshikimate
- K353 (= K341) binding 3-phosphoshikimate
2pqcA Cp4 epsps liganded with (r)-phosphonate tetrahedral reaction intermediate analog (see paper)
47% identity, 98% coverage: 5:422/428 of query aligns to 6:435/445 of 2pqcA
- active site: K23 (= K22), S24 (= S23), D50 (= D49), N93 (= N92), R123 (= R122), D321 (= D314), E349 (= E342), H399 (= H386), R400 (= R387), T426 (= T413)
- binding [3r-[3a,4a,5b(r*)]]-5-(1-carboxy-1-phosphonoethoxy)-4-hydroxy-3-(phosphonooxy)-1-cyclohexene-1-carboxylic acid: K23 (= K22), S24 (= S23), R28 (= R27), T96 (= T95), R123 (= R122), S168 (= S167), Q170 (= Q169), D321 (= D314), K348 (= K341), E349 (= E342), R352 (= R345), R400 (= R387)
2pqbA Cp4 epsps liganded with (r)-difluoromethyl tetrahedral intermediate analog (see paper)
47% identity, 98% coverage: 5:422/428 of query aligns to 6:435/445 of 2pqbA
- active site: K23 (= K22), S24 (= S23), D50 (= D49), N93 (= N92), R123 (= R122), D321 (= D314), E349 (= E342), H399 (= H386), R400 (= R387), T426 (= T413)
- binding (3r,4s,5r)-5-[(1r)-1-carboxy-2,2-difluoro-1-(phosphonooxy)ethoxy]-4-hydroxy-3-(phosphonooxy)cyclohex-1-ene-1-carboxylic acid: K23 (= K22), S24 (= S23), R28 (= R27), A95 (≠ G94), T96 (= T95), R123 (= R122), S168 (= S167), Q170 (= Q169), D321 (= D314), K348 (= K341), E349 (= E342), R352 (= R345), R400 (= R387)
2ggaA Cp4 epsp synthase liganded with s3p and glyphosate (see paper)
47% identity, 98% coverage: 5:422/428 of query aligns to 6:435/445 of 2ggaA
- active site: K23 (= K22), S24 (= S23), D50 (= D49), N93 (= N92), R123 (= R122), D321 (= D314), E349 (= E342), H399 (= H386), R400 (= R387), T426 (= T413)
- binding glyphosate: K23 (= K22), A94 (≠ S93), A95 (≠ G94), T96 (= T95), R123 (= R122), D321 (= D314), E349 (= E342), R352 (= R345), R400 (= R387)
- binding shikimate-3-phosphate: S24 (= S23), R28 (= R27), S168 (= S167), A169 (= A168), Q170 (= Q169), R195 (= R194), D321 (= D314), K348 (= K341)
2gg6A Cp4 epsp synthase liganded with s3p (see paper)
47% identity, 98% coverage: 5:422/428 of query aligns to 6:435/445 of 2gg6A
- active site: K23 (= K22), S24 (= S23), D50 (= D49), N93 (= N92), R123 (= R122), D321 (= D314), E349 (= E342), H399 (= H386), R400 (= R387), T426 (= T413)
- binding shikimate-3-phosphate: S24 (= S23), R28 (= R27), T96 (= T95), S168 (= S167), Q170 (= Q169), D321 (= D314), K348 (= K341)
3nvsA 1.02 angstrom resolution crystal structure of 3-phosphoshikimate 1- carboxyvinyltransferase from vibrio cholerae in complex with shikimate-3-phosphate (partially photolyzed) and glyphosate
32% identity, 98% coverage: 1:419/428 of query aligns to 1:418/426 of 3nvsA
- active site: K22 (= K22), S23 (= S23), D49 (= D49), N94 (= N92), P119 (≠ Q117), R124 (= R122), H128 (≠ R126), Q135 (≠ R133), Y142 (≠ G140), E144 (≠ A142), A247 (= A236), A255 (≠ L244), D314 (= D314), E342 (= E342), H386 (= H386), R387 (= R387), K412 (≠ T413)
- binding glyphosate: K22 (= K22), G96 (= G94), R124 (= R122), Q172 (= Q169), D314 (= D314), E342 (= E342), R345 (= R345), H386 (= H386), R387 (= R387)
- binding magnesium ion: E123 (≠ N121), Q145 (≠ G143)
- binding shikimate-3-phosphate: K22 (= K22), S23 (= S23), R27 (= R27), T97 (= T95), S170 (= S166), S171 (= S167), Q172 (= Q169), S198 (≠ T188), Y201 (≠ H191), D314 (= D314), N337 (≠ E337), K341 (= K341)
- binding (3r,4s,5r)-3,4,5-trihydroxycyclohex-1-ene-1-carboxylic acid: S23 (= S23), R27 (= R27), Q172 (= Q169), Y201 (≠ H191), D314 (= D314), K341 (= K341)
Q9KRB0 3-phosphoshikimate 1-carboxyvinyltransferase; 5-enolpyruvylshikimate-3-phosphate synthase; EPSP synthase; EPSPS; EC 2.5.1.19 from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
32% identity, 98% coverage: 1:419/428 of query aligns to 1:418/426 of Q9KRB0
- K22 (= K22) binding 3-phosphoshikimate
- S23 (= S23) binding 3-phosphoshikimate
- R27 (= R27) binding 3-phosphoshikimate
- S170 (= S166) binding 3-phosphoshikimate
- S171 (= S167) binding 3-phosphoshikimate
- S198 (≠ T188) binding 3-phosphoshikimate
- D314 (= D314) binding 3-phosphoshikimate
- N337 (≠ E337) binding 3-phosphoshikimate
- K341 (= K341) binding 3-phosphoshikimate
7tm5B Crystal structure of shikimate-3-phosphate bound 3-phosphoshikimate 1- carboxyvinyltransferase from klebsiella pneumoniae
29% identity, 99% coverage: 1:425/428 of query aligns to 1:423/427 of 7tm5B
- binding shikimate-3-phosphate: K22 (= K22), S23 (= S23), R27 (= R27), S169 (= S167), S170 (≠ A168), Q171 (= Q169), S197 (≠ T188), Y200 (≠ H191), D313 (= D314), N336 (≠ E337), K340 (= K341)
7tm6A Crystal structure of shikimate-3-phosphate and glyphosate bound 3- phosphoshikimate 1-carboxyvinyltransferase from klebsiella pneumoniae
29% identity, 99% coverage: 2:425/428 of query aligns to 1:422/426 of 7tm6A
- binding glyphosate: K21 (= K22), G95 (= G94), R123 (= R122), Q170 (= Q169), D312 (= D314), E340 (= E342), R343 (= R345), H384 (= H386), R385 (= R387)
- binding shikimate-3-phosphate: S22 (= S23), R26 (= R27), T96 (= T95), S168 (= S167), S169 (≠ A168), Q170 (= Q169), S196 (≠ T188), Y199 (≠ H191), D312 (= D314), N335 (≠ E337), K339 (= K341)
2pq9A E. Coli epsps liganded with (r)-difluoromethyl tetrahedral reaction intermediate analog (see paper)
31% identity, 99% coverage: 1:425/428 of query aligns to 1:423/427 of 2pq9A
- active site: K22 (= K22), S23 (= S23), D49 (= D49), N94 (= N92), P119 (≠ Q117), R124 (= R122), D313 (= D314), E341 (= E342), H385 (= H386), R386 (= R387), K411 (≠ T413)
- binding (3r,4s,5r)-5-[(1r)-1-carboxy-2,2-difluoro-1-(phosphonooxy)ethoxy]-4-hydroxy-3-(phosphonooxy)cyclohex-1-ene-1-carboxylic acid: K22 (= K22), S23 (= S23), R27 (= R27), G96 (= G94), T97 (= T95), R124 (= R122), S169 (= S166), S170 (= S167), Q171 (= Q169), S197 (≠ T188), Y200 (≠ H191), D313 (= D314), N336 (≠ E337), K340 (= K341), R344 (= R345), H385 (= H386), R386 (= R387), K411 (≠ T413)
2aa9A Epsp synthase liganded with shikimate (see paper)
31% identity, 99% coverage: 1:425/428 of query aligns to 1:423/427 of 2aa9A
- active site: K22 (= K22), S23 (= S23), D49 (= D49), N94 (= N92), P119 (≠ Q117), R124 (= R122), D313 (= D314), E341 (= E342), H385 (= H386), R386 (= R387), K411 (≠ T413)
- binding (3r,4s,5r)-3,4,5-trihydroxycyclohex-1-ene-1-carboxylic acid: K22 (= K22), S23 (= S23), R27 (= R27), T97 (= T95), Q171 (= Q169), Y200 (≠ H191), D313 (= D314), K340 (= K341)
1x8tA Epsps liganded with the (r)-phosphonate analog of the tetrahedral reaction intermediate (see paper)
31% identity, 99% coverage: 1:425/428 of query aligns to 1:423/427 of 1x8tA
- active site: K22 (= K22), S23 (= S23), D49 (= D49), N94 (= N92), P119 (≠ Q117), R124 (= R122), D313 (= D314), E341 (= E342), H385 (= H386), R386 (= R387), K411 (≠ T413)
- binding [3r-[3a,4a,5b(r*)]]-5-(1-carboxy-1-phosphonoethoxy)-4-hydroxy-3-(phosphonooxy)-1-cyclohexene-1-carboxylic acid: K22 (= K22), S23 (= S23), R27 (= R27), T97 (= T95), S169 (= S166), S170 (= S167), Q171 (= Q169), S197 (≠ T188), Y200 (≠ H191), D313 (= D314), N336 (≠ E337), K340 (= K341), R344 (= R345), H385 (= H386), R386 (= R387)
1x8rA Epsps liganded with the (s)-phosphonate analog of the tetrahedral reaction intermediate (see paper)
31% identity, 99% coverage: 1:425/428 of query aligns to 1:423/427 of 1x8rA
- active site: K22 (= K22), S23 (= S23), D49 (= D49), N94 (= N92), P119 (≠ Q117), R124 (= R122), D313 (= D314), E341 (= E342), H385 (= H386), R386 (= R387), K411 (≠ T413)
- binding [3r-[3a,4a,5b(s*)]]-5-(1-carboxy-1-phosphonoethoxy)-4-hydroxy-3-(phosphonooxy)-1-cyclohexene-1-carboxylic acid: K22 (= K22), S23 (= S23), R27 (= R27), G96 (= G94), T97 (= T95), R124 (= R122), S169 (= S166), S170 (= S167), Q171 (= Q169), S197 (≠ T188), Y200 (≠ H191), D313 (= D314), N336 (≠ E337), K340 (= K341), E341 (= E342), H385 (= H386), K411 (≠ T413)
1g6tA Structure of epsp synthase liganded with shikimate-3-phosphate (see paper)
31% identity, 99% coverage: 1:425/428 of query aligns to 1:423/427 of 1g6tA
- active site: K22 (= K22), S23 (= S23), D49 (= D49), N94 (= N92), P119 (≠ Q117), R124 (= R122), D313 (= D314), E341 (= E342), H385 (= H386), R386 (= R387), K411 (≠ T413)
- binding phosphate ion: K22 (= K22), G96 (= G94), T97 (= T95), R124 (= R122), Q171 (= Q169), E341 (= E342), K411 (≠ T413)
- binding shikimate-3-phosphate: K22 (= K22), S23 (= S23), R27 (= R27), T97 (= T95), S169 (= S166), S170 (= S167), Q171 (= Q169), S197 (≠ T188), Y200 (≠ H191), D313 (= D314), N336 (≠ E337), K340 (= K341)
Query Sequence
>WP_011938379.1 NCBI__GCF_000016745.1:WP_011938379.1
MQTYTIKPAQSVRGEIAVPGDKSISHRSIMLGSIARGTTTVCGFLRGEDNMATLNAFRAM
GVDVRDDGETLRIEGKGLAGLSEPTDVLDCGNSGTSMRLMTGLLAGQRFFSVLTGDQYLR
NRPMKRVLEPLSRMGATIFGRAGGDKAPLAVVGRGLTGVTYASPVSSAQVKSAILLAGLY
ADGETEVTEPHLSRDHSERMLRYFGADIETFAGGVKVRGRELTGRDITVPGDISSAAFFI
VAALIVPGSELLIKGVGVNPTRTGIIDILTAMGGSIELLNCREISGEPVADLLVRASELK
GIEIGGDLVPRAIDEFPVICVAASCAEGRTVIRDARELRVKETDRIAAMAVNLRKAGVDV
VETENGMELIGVERLEGCTAESFGDHRIAMSMLIAGLAARGEITVNDTECIATSFPNFIA
LLEKVVVP
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SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory