SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing WP_011941019.1 NCBI__GCF_000016745.1:WP_011941019.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

3bs8A Crystal structure of glutamate 1-semialdehyde aminotransferase complexed with pyridoxamine-5'-phosphate from bacillus subtilis (see paper)
61% identity, 100% coverage: 2:427/427 of query aligns to 3:427/430 of 3bs8A

query
sites
3bs8A

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active site: V22 (= V21), Y145 (= Y144), E207 (= E206), D240 (= D239), M243 (= M242), K268 (= K267), G401 (≠ T401)
binding 4'-deoxy-4'-aminopyridoxal-5'-phosphate: G118 (= G117), T119 (= T118), Y145 (= Y144), H146 (= H145), E207 (= E206), N212 (= N211), D240 (= D239), V242 (= V241), K268 (= K267)

P23893 Glutamate-1-semialdehyde 2,1-aminomutase; GSA; Glutamate-1-semialdehyde aminotransferase; GSA-AT; EC 5.4.3.8 from Escherichia coli (strain K12) (see paper)
60% identity, 99% coverage: 4:427/427 of query aligns to 2:426/426 of P23893

query
sites
P23893

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K265 (= K267) mutation to R: 2% of wild-type activity.

5i92F Crystal structure of glutamate-1-semialdehyde 2,1- aminomutase (gsa) from pseudomonas aeruginosa
61% identity, 99% coverage: 4:426/427 of query aligns to 2:420/420 of 5i92F

query
sites
5i92F

S

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A

E

K

K

A
|
A

F
|
F

K

A

S
x
A

active site: V19 (= V21), Y142 (= Y144), E201 (= E206), D234 (= D239), M237 (= M242), K262 (= K267), A395 (≠ T401)
binding leucine: A417 (= A423), F418 (= F424), A420 (≠ S426)

Q42522 Glutamate-1-semialdehyde 2,1-aminomutase 2, chloroplastic; GSA 2; Glutamate-1-semialdehyde aminotransferase 2; GSA-AT 2; EC 5.4.3.8 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
58% identity, 99% coverage: 5:427/427 of query aligns to 50:472/472 of Q42522

query
sites
Q42522

R

K

S

S

E

E

L

E

L

A

F

F

Q

N

E

A

A

A

Q

K

K

N

A

L

I

M

P

P

G

G

G

G

V

V

N

N

S

S

P

P

V

V

R

R

A

A

F

F

K

K

S

S

V

V

G

G

T

G

D

Q

P

P

L

V

F

V

I

M

E

D

K

S

A

A

S

K

G

G

S

S

R

R

I

I

Y
x
R

D

D

V

I

D

D

G

G

N

N

E

E

F

Y

I

I

D

D

Y

Y

V

V

G

G

S

S

W

W

G

G

P

P

M

A

I

I

L

I

G

G

H

H

C

A

H

D

P

D

Q

E

V

V

V

L

A

A

A

A

V

L

K

A

S

E

A

T

V

M

D

K

N

K

G

G

C

T

S

S

F

F

G

G

A

A

P

P

T

C

E

L

L

L

E

E

I

N

T

V

L

L

A

A

E

E

M

M

V

V

I

I

E

S

A

A

V

V

P

P

S

S

I

I

E

E

M

M

V

V

R

R

M

F

V

V

S

N

S

S

G
|
G

T

T

E

E

A

A

T

C

M

M

S

G

A

V

I

L

R

R

L

L

A

A

R

R

G

A

Y

F

T

T

G

G

R

K

D

Q

K

K

I

F

L

I

K

K

F

F

S

E

G

G

C

C

Y

Y

H

H

G

G

H

H

S

A

D

N

S

S

L

F

L

L

V

V

K

K

A

A

G

G

S

S

G

G

A

V

A

A

T

T

F

L

G

G

V

L

P

P

D

D

S

S

P

P

G

G

V

V

P

P

Q

K

D

A

F

A

A

T

K

S

H

D

T

T

L

L

T

T

A

A

T

P

Y

Y

N

N

D

D

L

I

E

A

S

A

V

V

N

E

K

K

L

L

V

F

A

E

E

A

N

N

K

K

N

G

Q

E

I

I

S

A

C

A

I

I

I

I

V

L

E

E

P

P

V

V

A

V

G

G

N

N

M

S

G

G

T

F

V

I

P

T

P

P

R

K

E

P

G

E

F

F

L

I

E

E

G

G

L

I

R

R

S

R

L

I

C

T

T

K

E

D

E

N

G

G

I

A

V

L

L

L

I

I

F

F

D

D

E

E

V

V

M

M

S

T

G

G

F

F

R

R

V

L

A

A

Y

Y

G

G

G

G

A

A

Q

Q

E

E

L

Y

Y

F

N

G

V

I

T

T

P

P

D

D

M

L

T

T

T

T

L

L

G

G

K

K

I

I

I

I

G

G

G

G

G

G

L

L

P

P

V

V

G

G

A

A

F

Y

G

G

G

G

K

R

K

R

E

D

I

I

M

M

S

E

L

M

L

V

S

A

P

P

S

A

G

G

G

P

V

M

Y

Y

Q

Q

A

A

G

G

T

T

L

L

S

S

G

G

N

N

P

P

L

L

A

A

M

M

T

T

A

A

G

G

I

I

E

H

T

T

L

L

K

K

L

R

L

L

Q

S

T

Q

E

P

G

G

F

T

Y

Y

Q

E

D

Y

L

L

D

D

R

K

K

I

S

T

D

K

Y

E

V

L

A

T

S

N

G

G

I

I

A

L

K

E

A

A

A

G

K

K

D

K

A

T

G

G

F

H

P

A

I

M

Y

C

S

G

T

G

R

Y

V

I

G

S

S

G

M

M

F

F

C

G

A

F

F

F

F

F

S

T

K

E

K

G

P

P

V

V

Y

Y

D

D

W

F

T

S

S

D

A

A

A

K

A

K

C

S

D

D

T

T

K

E

A

K

F

F

A

G

K

K

Y

F

F

F

R

R

L

G

M

M

L

L

D

E

E

E

G

G

I

V

Y

Y

L

L

A

A

P

P

S

S

Q

Q

F

F

E

E

T

A

A

G

F

F

V

T

S

S

I

L

A

A

H

H

S

T

T

S

D

E

D

D

L

I

D

Q

K

F

T

T

I

I

A

A

A

A

A

A

A

E

K

K

A

V

F

L

K

S

S

R

L

L

R92 (≠ Y47) mutation to K: In gsa2-1; suppression of enf1 mutant pleiotropic developmental phenotypes; when associated with S-162.
G162 (= G117) mutation to S: In gsa2-1; suppression of enf1 mutant pleiotropic developmental phenotypes; when associated with K-92.

5hdmB Crystal structure of arabidopsis thaliana glutamate-1-semialdehyde-2, 1-aminomutase (see paper)
57% identity, 99% coverage: 4:427/427 of query aligns to 5:428/428 of 5hdmB

query
sites
5hdmB

S

Q

R

K

S

S

E

E

L

E

L

A

F

F

Q

N

E

A

A

A

Q

K

K

N

A

L

I

M

P

P

G

G

G

G

V
|
V

N

N

S

S

P

P

V

V

R

R

A

A

F

F

K

K

S

S

V

V

G

G

T

G

D

Q

P

P

L

V

F

L

I

I

E

D

K

S

A

V

S

K

G

G

S

S

R

K

I

M

Y

W

D

D

V

I

D

D

G

G

N

N

E

E

F

Y

I

I

D

D

Y

Y

V

V

G

G

S

S

W

W

G

G

P

P

M

A

I

I

L

I

G

G

H

H

C

A

H

D

P

D

Q

E

V

V

V

L

A

A

A

A

V

L

K

A

S

E

A

T

V

M

D

K

N

K

G

G

C

T

S

S

F

F

G

G

A

A

P

P

T

C

E

L

L

L

E

E

I

N

T

V

L

L

A

A

E

E

M

M

V

V

I

I

E

S

A

A

V

V

P

P

S

S

I

I

E

E

M

M

V

V

R

R

M

F

V

V

S

N

S

S

G
|
G

T
|
T

E

E

A

A

T

C

M

M

S

G

A

V

I

L

R

R

L

L

A

A

R

R

G

A

Y

F

T

T

G

N

R

K

D

E

K

K

I

F

L

I

K

K

F

F

S

E

G

G

C

C

Y
|
Y

H

H

G

G

H

H

S

A

D

N

S

A

L

F

L

L

V

V

K

K

A

A

G

G

S

S

G

G

A

V

A

A

T

T

F

L

G

G

V

L

P

P

D

D

S

S

P

P

G

G

V

V

P

P

Q

K

D

A

F

A

A

T

K

S

H

D

T

T

L

L

T

T

A

A

T

P

Y

Y

N

N

D

D

L

L

E

E

S

A

V

V

N

E

K

K

L

L

V

F

A

A

E

A

N

H

K

K

N

G

Q

E

I

I

S

S

C

A

I

V

I

I

V

L

E
|
E

P

P

V

V

A

V

G

G

N
|
N

M

S

G

G

T

F

V

I

P

P

P

P

R

T

E

P

G

E

F

F

L

I

E

N

G

G

L

L

R

R

S

Q

L

L

C

T

T

K

E

D

E

N

G

G

I

V

V

L

L

L

I

I

F

F

D
|
D

E

E

V
|
V

M
|
M

S

T

G

G

F

F

R

R

V

L

A

A

Y

Y

G

G

G

G

A

A

Q

Q

E

E

L

Y

Y

F

N

G

V

I

T

T

P

P

D

D

M

L

T

T

T

T

L

L

G

G

K
|
K

I

I

I

I

G

G

G

G

G

G

L

L

P

P

V

V

G

G

A

A

F

Y

G

G

G

G

K

R

K

R

E

D

I

I

M

M

S

E

L

M

L

V

S

A

P

P

S

A

G

G

G

P

V

M

Y

Y

Q

Q

A

A

G

G

T

T

L

L

S

S

G

G

N

N

P

P

L

L

A

A

M

M

T

T

A

A

G

G

I

I

E

H

T

T

L

L

K

K

L

R

L

L

Q

K

T

Q

E

A

G

G

F

T

Y

Y

Q

E

D

Y

L

L

D

D

R

K

K

I

S

T

D

K

Y

E

V

L

A

T

S

N

G

G

I

I

A

L

K

E

A

A

A

G

K

K

D

K

A

T

G

G

F

H

P

P

I

M

Y

C

S

G

T

G

R

Y

V

I

G

S

S

G

M

M

F

F

C

G

A

F

F

F

F

F

S

A

K

E

K

G

P

P

V

V

Y

Y

D

N

W

F

T

A

S

D

A

S

A

K

A

K

C

S

D

D

T

T

K

E

A

K

F

F

A

G

K

R

Y

F

F

F

R

R

L

G

M

M

L

L

D

E

E

E

G

G

I

V

Y

Y

L

F

A

A

P

P

S

S

Q

Q

F

F

E

E

T
x
A

A

G

F

F

V

T

S

S

I

L

A

A

H

H

S

T

T

P

D

E

D

D

L

I

D

Q

K

L

T

T

I

I

A

A

A

A

A

A

A

E

K

R

A

V

F

L

K

S

S

R

L

I

active site: V22 (= V21), Y145 (= Y144), E207 (= E206), D240 (= D239), M243 (= M242), K268 (= K267), A402 (≠ T401)
binding pyridoxal-5'-phosphate: G118 (= G117), T119 (= T118), Y145 (= Y144), E207 (= E206), N212 (= N211), D240 (= D239), V242 (= V241), M243 (= M242), K268 (= K267)
binding 4'-deoxy-4'-aminopyridoxal-5'-phosphate: G118 (= G117), T119 (= T118), Y145 (= Y144), E207 (= E206), N212 (= N211), D240 (= D239), V242 (= V241), M243 (= M242), K268 (= K267)

5hdmA Crystal structure of arabidopsis thaliana glutamate-1-semialdehyde-2, 1-aminomutase (see paper)
57% identity, 99% coverage: 4:427/427 of query aligns to 5:428/428 of 5hdmA

query
sites
5hdmA

S

Q

R

K

S

S

E

E

L

E

L

A

F

F

Q

N

E

A

A

A

Q

K

K

N

A

L

I

M

P

P

G

G

G

G

V
|
V

N

N

S

S

P

P

V

V

R

R

A

A

F

F

K

K

S

S

V

V

G

G

T

G

D

Q

P

P

L

V

F

L

I

I

E

D

K

S

A

V

S

K

G

G

S

S

R

K

I

M

Y

W

D

D

V

I

D

D

G

G

N

N

E

E

F

Y

I

I

D

D

Y

Y

V

V

G

G

S

S

W

W

G

G

P

P

M

A

I

I

L

I

G

G

H

H

C

A

H

D

P

D

Q

E

V

V

V

L

A

A

A

A

V

L

K

A

S

E

A

T

V

M

D

K

N

K

G

G

C

T

S

S

F

F

G

G

A

A

P

P

T

C

E

L

L

L

E

E

I

N

T

V

L

L

A

A

E

E

M

M

V

V

I

I

E

S

A

A

V

V

P

P

S

S

I

I

E

E

M

M

V

V

R

R

M

F

V

V

S

N

S

S

G
|
G

T
|
T

E

E

A

A

T

C

M

M

S

G

A

V

I

L

R

R

L

L

A

A

R

R

G

A

Y

F

T

T

G

N

R

K

D

E

K

K

I

F

L

I

K

K

F

F

S

E

G

G

C

C

Y
|
Y

H

H

G
|
G

H

H

S

A

D

N

S

A

L

F

L

L

V

V

K

K

A

A

G

G

S

S

G

G

A

V

A

A

T

T

F

L

G

G

V

L

P

P

D

D

S

S

P

P

G

G

V

V

P

P

Q

K

D

A

F

A

A

T

K

S

H

D

T

T

L

L

T

T

A

A

T

P

Y

Y

N

N

D

D

L

L

E

E

S

A

V

V

N

E

K

K

L

L

V

F

A

A

E

A

N

H

K

K

N

G

Q

E

I

I

S

S

C

A

I

V

I

I

V

L

E
|
E

P

P

V

V

A

V

G

G

N
|
N

M

S

G

G

T

F

V

I

P

P

P

P

R

T

E

P

G

E

F

F

L

I

E

N

G

G

L

L

R

R

S

Q

L

L

C

T

T

K

E

D

E

N

G

G

I

V

V

L

L

L

I

I

F

F

D
|
D

E

E

V
|
V

M
|
M

S

T

G

G

F

F

R

R

V

L

A

A

Y

Y

G

G

G

G

A

A

Q

Q

E

E

L

Y

Y

F

N

G

V

I

T

T

P

P

D

D

M

L

T

T

T

T

L

L

G

G

K
|
K

I

I

I

I

G

G

G

G

G

G

L

L

P

P

V

V

G

G

A

A

F

Y

G

G

G

G

K

R

K

R

E

D

I

I

M

M

S

E

L

M

L

V

S

A

P

P

S

A

G

G

G

P

V

M

Y

Y

Q

Q

A

A

G

G

T

T

L

L

S

S

G

G

N

N

P

P

L

L

A

A

M

M

T

T

A

A

G

G

I

I

E

H

T

T

L

L

K

K

L

R

L

L

Q

K

T

Q

E

A

G

G

F

T

Y

Y

Q

E

D

Y

L

L

D

D

R

K

K

I

S

T

D

K

Y

E

V

L

A

T

S

N

G

G

I

I

A

L

K

E

A

A

A

G

K

K

D

K

A

T

G

G

F

H

P

P

I

M

Y

C

S

G

T

G

R

Y

V

I

G

S

S

G

M

M

F

F

C

G

A

F

F

F

F

F

S

A

K

E

K

G

P

P

V

V

Y

Y

D

N

W

F

T

A

S

D

A

S

A

K

A

K

C

S

D

D

T

T

K

E

A

K

F

F

A

G

K

R

Y

F

F

F

R

R

L

G

M

M

L

L

D

E

E

E

G

G

I

V

Y

Y

L

F

A

A

P

P

S

S

Q

Q

F

F

E

E

T
x
A

A

G

F

F

V

T

S

S

I

L

A

A

H

H

S

T

T

P

D

E

D

D

L

I

D

Q

K

L

T

T

I

I

A

A

A

A

A

A

A

E

K

R

A

V

F

L

K

S

S

R

L

I

active site: V22 (= V21), Y145 (= Y144), E207 (= E206), D240 (= D239), M243 (= M242), K268 (= K267), A402 (≠ T401)
binding 4'-deoxy-4'-aminopyridoxal-5'-phosphate: G118 (= G117), T119 (= T118), Y145 (= Y144), G147 (= G146), E207 (= E206), N212 (= N211), D240 (= D239), V242 (= V241), K268 (= K267)

P42799 Glutamate-1-semialdehyde 2,1-aminomutase 1, chloroplastic; AtGSA1; GSA 1; Glutamate-1-semialdehyde aminotransferase 1; GSA-AT 1; EC 5.4.3.8 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
57% identity, 99% coverage: 5:427/427 of query aligns to 52:474/474 of P42799

query
sites
P42799

R

K

S

S

E

E

L

E

L

A

F

F

Q

N

E

A

A

A

Q

K

K

N

A

L

I

M

P

P

G

G

G

G

V

V

N

N

S

S

P

P

V

V

R

R

A

A

F

F

K

K

S

S

V

V

G

G

T

G

D

Q

P

P

L

V

F

L

I

I

E

D

K

S

A

V

S

K

G

G

S

S

R

K

I

M

Y

W

D

D

V

I

D

D

G

G

N

N

E

E

F

Y

I

I

D

D

Y

Y

V

V

G

G

S

S

W

W

G

G

P

P

M

A

I

I

L

I

G

G

H

H

C

A

H

D

P

D

Q

E

V

V

V

L

A

A

A

A

V

L

K

A

S

E

A

T

V

M

D

K

N

K

G

G

C

T

S

S

F

F

G

G

A

A

P

P

T

C

E

L

L

L

E

E

I

N

T

V

L

L

A

A

E

E

M

M

V

V

I

I

E

S

A

A

V

V

P

P

S

S

I

I

E

E

M

M

V

V

R

R

M

F

V

V

S

N

S

S

G

G

T

T

E

E

A

A

T

C

M

M

S

G

A

V

I

L

R

R

L

L

A

A

R

R

G

A

Y

F

T

T

G

N

R

K

D

E

K

K

I

F

L

I

K

K

F

F

S

E

G

G

C

C

Y

Y

H

H

G

G

H

H

S

A

D

N

S

A

L

F

L

L

V

V

K

K

A

A

G

G

S

S

G

G

A

V

A

A

T

T

F

L

G

G

V

L

P

P

D

D

S

S

P

P

G

G

V

V

P

P

Q

K

D

A

F

A

A

T

K

S

H

D

T

T

L

L

T

T

A

A

T

P

Y

Y

N

N

D

D

L

L

E

E

S

A

V

V

N

E

K

K

L

L

V

F

A

A

E

A

N

H

K

K

N

G

Q

E

I

I

S

S

C

A

I

V

I

I

V

L

E

E

P

P

V

V

A

V

G

G

N

N

M

S

G

G

T

F

V

I

P

P

P

P

R

T

E

P

G

E

F

F

L

I

E

N

G

G

L

L

R

R

S

Q

L

L

C

T

T

K

E

D

E

N

G

G

I

V

V

L

L

L

I

I

F

F

D

D

E

E

V

V

M

M

S

T

G

G

F

F

R

R

V

L

A

A

Y

Y

G

G

G

G

A

A

Q

Q

E

E

L

Y

Y

F

N

G

V

I

T

T

P

P

D

D

M

L

T

T

T

T

L

L

G

G

K
|
K

I

I

I

I

G

G

G

G

G

G

L

L

P

P

V

V

G

G

A

A

F

Y

G

G

G

G

K

R

K

R

E

D

I

I

M

M

S

E

L

M

L

V

S

A

P

P

S

A

G

G

G

P

V

M

Y

Y

Q

Q

A

A

G

G

T

T

L

L

S

S

G

G

N

N

P

P

L

L

A

A

M

M

T

T

A

A

G

G

I

I

E

H

T

T

L

L

K

K

L

R

L

L

Q

K

T

Q

E

A

G

G

F

T

Y

Y

Q

E

D

Y

L

L

D

D

R

K

K

I

S

T

D

K

Y

E

V

L

A

T

S

N

G

G

I

I

A

L

K

E

A

A

A

G

K

K

D

K

A

T

G

G

F

H

P

P

I

M

Y

C

S

G

T

G

R

Y

V

I

G

S

S

G

M

M

F

F

C

G

A

F

F

F

F

F

S

A

K

E

K

G

P

P

V

V

Y

Y

D

N

W

F

T

A

S

D

A

S

A

K

A

K

C

S

D

D

T

T

K

E

A

K

F

F

A

G

K

R

Y

F

F

F

R

R

L

G

M

M

L

L

D

E

E

E

G

G

I

V

Y

Y

L

F

A

A

P

P

S

S

Q

Q

F

F

E

E

T

A

A

G

F

F

V

T

S

S

I

L

A

A

H

H

S

T

T

P

D

E

D

D

L

I

D

Q

K

L

T

T

I

I

A

A

A

A

A

A

A

E

K

R

A

V

F

L

K

S

S

R

L

I

K314 (= K267) modified: N6-(pyridoxal phosphate)lysine

3k28A Crystal structure of a glutamate-1-semialdehyde aminotransferase from bacillus anthracis with bound pyridoxal 5'phosphate
60% identity, 96% coverage: 3:412/427 of query aligns to 4:407/423 of 3k28A

query
sites
3k28A

Y

F

S

D

R

K

S

S

E

I

L

A

L

A

F

F

Q

E

E

E

A

A

Q

Q

K

D

A

L

I

M

P

P

G

G

G

G

V
|
V

N

N

S

S

P

P

V

V

R

R

A

A

F

F

K

K

S

S

V

V

G

G

T

M

D

N

P

P

L

L

F

F

I

M

E

E

K

R

A

G

S

K

G

G

S

S

R

K

I

V

Y

Y

D

D

V

I

D

D

G

G

N

N

E

E

F

Y

I

I

D

D

Y

Y

V

V

G

L

S

S

W

W

G

G

P

P

M

L

I

I

L

H

G

G

H

H

C

A

H

N

P

D

Q

R

V

V

V

V

A

E

A

A

V

L

K

K

S

A

A

V

V

A

D

E

N

R

G

G

C

T

S

S

F

F

G

G

A

A

P

P

T

T

E

E

L

I

E

E

I

N

T

K

L

L

A

A

E

K

M

L

V

V

I
|
I

E

E

A

R

V
|
V

P
|
P

S

S

I
|
I

E

E

M

I

V

V

R

R

M

M

V

V

S

N

S

S

G
|
G

T
|
T

E

E

A

A

T

T

M

M

S

S

A

A

I

L

R

R

L

L

A

A

R

R

G

G

Y

Y

T

T

G

G

R

R

D

N

K

K

I

I

L

L

K

K

F

F

S

I

G

G

C

C

Y
|
Y

H
|
H

G
|
G

H

H

S

G

D

D

S

S

L

L

L

L

V

I

K

K

A

A

G

G

S

S

G

-

A

-

A

-

T

-

F

-

G

G

V

V

P

P

D

D

S

S

P

P

G

G

V

V

P

P

Q

E

D

G

F

V

A

A

K

K

H

N

T

T

L

I

T

T

A

V

T

A

Y

Y

N

N

D

D

L

L

E

E

S

S

V

V

N

K

K

Y

L

A

V

F

A

E

E

Q

N

F

K

G

N

D

Q

D

I

I

S

A

C

C

I

V

I

I

V

V

E
|
E

P

P

V

V

A

A

G

G

N

N

M

M

G

G

T

V

V

V

P

P

P

P

R

Q

E

P

G

G

F

F

L

L

E

E

G

G

L

L

R

R

S

E

L

V

C

T

T

E

E

Q

E

N

G

G

I

A

V

L

L

L

I

I

F

F

D
|
D

E

E

V
|
V

M
|
M

S

T

G

G

F

F

R

R

V

V

A

A

Y

Y

G

N

G

C

A

G

Q

Q

E

G

L

Y

Y

Y

N

G

V

V

T

T

P

P

D

D

M

L

T

T

T

C

L

L

G

G

K
|
K

I

V

I

I

G

G

G

G

G

G

L

L

P

P

V

V

G

G

A

A

F

Y

G

G

G

G

K

K

K

A

E

E

I

I

M

M

S

R

L

Q

L

V

S

A

P

P

S

S

G

G

G

P

V

I

Y

Y

Q

Q

A

A

G

G

T

T

L

L

S

S

G

G

N

N

P

P

L

L

A

A

M

M

T

A

A

A

G

G

I

Y

E

E

T

T

L

L

K

V

L

Q

L

L

Q

T

T

P

E

E

G

S

F

-

Y

Y

Q

V

D

E

L

F

D

E

R

R

K

K

S

A

D

E

Y

M

V

L

A

E

S

A

G

G

I

L

A

R

K

K

A

A

A

A

K

E

D

K

A

H

G

G

F

I

P

P

I

H

Y

H

S

I

T

N

R

R

V

A

G

G

S

S

M

M

F

I

C

G

A

I

F

F

F

F

S

T

K

D

K

E

P

P

V

V

Y

I

D

N

W

Y

T

D

S

A

A

A

A

K

A

S

C

S

D

N

T

L

K

Q

A

F

F

F

A

A

K

A

Y

Y

F

Y

R

R

L

E

M

M

L

V

D

E

E

Q

G

G

I

V

Y

F

L

L

A

P

P

P

S

S

Q

Q

F

F

E

E

T
x
G

A

L

F

F

V

L

S

S

I

T

A

V

H

H

S

S

T

D

D

A

D

D

active site: V22 (= V21), Y145 (= Y144), E202 (= E206), D235 (= D239), M238 (= M242), K263 (= K267), G396 (≠ T401)
binding calcium ion: I103 (= I102), V106 (= V105), P107 (= P106), I109 (= I108)
binding pyridoxal-5'-phosphate: G118 (= G117), T119 (= T118), Y145 (= Y144), H146 (= H145), G147 (= G146), E202 (= E206), D235 (= D239), V237 (= V241), M238 (= M242), K263 (= K267)

2gsaB Crystal structure of glutamate-1-semialdehyde aminomutase (aminotransferase, wild-type form) (see paper)
57% identity, 99% coverage: 5:427/427 of query aligns to 5:427/427 of 2gsaB

query
sites
2gsaB

R

K

S

S

E

D

L

E

L

I

F

F

Q

A

E

A

A

A

Q

Q

K

K

A

L

I

M

P

P

G

G

G

G

V
|
V

N

S

S

S

P

P

V

V

R

R

A

A

F

F

K

K

S

S

V

V

G

G

T

G

D

Q

P

P

L

I

F

V

I

F

E

D

K

R

A

V

S

K

G

D

S

A

R

Y

I

A

Y

W

D

D

V

V

D

D

G

G

N

N

E

R

F

Y

I

I

D

D

Y

Y

V

V

G

G

S

T

W

W

G

G

P

P

M

A

I

I

L

C

G

G

H

H

C

A

H

H

P

P

Q

E

V

V

V

I

A

E

A

A

V

L

K

K

S

V

A

A

V

M

D

E

N

K

G

G

C

T

S

S

F

F

G

G

A

A

P

P

T

C

E

A

L

L

E

E

I

N

T

V

L

L

A

A

E

E

M

M

V

V

I

N

E

D

A

A

V

V

P

P

S

S

I

I

E

E

M

M

V

V

R

R

M

F

V

V

S

N

S

S

G
|
G

T
|
T

E

E

A

A

T

C

M

M

S

A

A

V

I

L

R

R

L

L

A

M

R

R

G

A

Y

Y

T

T

G

G

R

R

D

D

K

K

I

I

L

I

K

K

F

F

S

E

G

G

C

C

Y
|
Y

H

H

G

G

H

H

S

A

D

D

S

M

L

F

L

L

V

V

K

K

A

A

G

G

S

S

G

G

A

V

A

A

T

T

F

L

G

G

V

L

P

P

D

S

S

S

P

P

G

G

V

V

P

P

Q

K

D

K

F

T

A

T

K

A

H

N

T

T

L

L

T

T

A

T

T

P

Y

Y

N

N

D

D

L

L

E

E

S

A

V

V

N

K

K

A

L

L

V

F

A

A

E

E

N

N

K

P

N

G

Q

E

I

I

S

A

C

G

I

V

I

I

V

L

E
|
E

P

P

V

I

A

V

G

G

N
|
N

M

S

G

G

T

F

V

I

P

V

P

P

R

D

E

A

G

G

F

F

L

L

E

E

G

G

L

L

R

R

S

E

L

I

C

T

T

L

E

E

E

H

G

D

I

A

V

L

L

L

I

V

F

F

D
|
D

E

E

V
|
V

M
|
M

S

T

G

G

F

F

R

R

V

I

A

A

Y

Y

G

G

G

G

A

V

Q

Q

E

E

L

K

Y

F

N

G

V

V

T

T

P

P

D

D

M

L

T

T

T

T

L

L

G

G

K
|
K

I

I

I

I

G

G

G

G

G

G

L

L

P

P

V

V

G

G

A

A

F

Y

G

G

G

G

K

K

K

R

E

E

I

I

M

M

S

Q

L

L

L

V

S

A

P

P

S

A

G

G

G

P

V

M

Y

Y

Q

Q

A

A

G

G

T

T

L

L

S

S

G

G

N

N

P

P

L

L

A

A

M

M

T

T

A

A

G

G

I

I

E

K

T

T

L

L

K

E

L

L

L

L

Q

R

T

Q

E

P

G

G

F

T

Y

Y

Q

E

D

Y

L

L

D

D

R

Q

K

I

S

T

D

K

Y

R

V

L

A

S

S

D

G

G

I

L

A

L

K

A

A

I

A

A

K

Q

D

E

A

T

G

G

F

H

P

A

I

A

Y

C

S

G

T

G

R

Q

V

V

G

S

S

G

M

M

F

F

C

G

A

F

F

F

F

F

S

T

K

E

K

G

P

P

V

V

Y

H

D

N

W

Y

T

E

S

D

A

A

A

K

A

K

C

S

D

D

T

L

K

Q

A

K

F

F

A

S

K

R

Y

F

F

H

R

R

L

G

M

M

L

L

D

E

E

Q

G

G

I

I

Y

Y

L

L

A

A

P

P

S

S

Q

Q

F

F

E

E

T
x
A

A

G

F

F

V

T

S

S

I

L

A

A

H

H

S

T

T

E

D

E

D

D

L

I

D

D

K

A

T

T

I

L

A

A

A

A

A

A

A

R

K

T

A

V

F

M

K

S

S

A

L

L

active site: V21 (= V21), Y144 (= Y144), E206 (= E206), D239 (= D239), M242 (= M242), K267 (= K267), A401 (≠ T401)
binding pyridoxal-5'-phosphate: G117 (= G117), T118 (= T118), Y144 (= Y144), E206 (= E206), N211 (= N211), D239 (= D239), V241 (= V241), M242 (= M242), K267 (= K267)

2gsaA Crystal structure of glutamate-1-semialdehyde aminomutase (aminotransferase, wild-type form) (see paper)
57% identity, 99% coverage: 5:427/427 of query aligns to 5:427/427 of 2gsaA

query
sites
2gsaA

R

K

S

S

E

D

L

E

L

I

F

F

Q

A

E

A

A

A

Q

Q

K

K

A

L

I

M

P

P

G

G

G

G

V
|
V

N

S

S

S

P

P

V

V

R

R

A

A

F

F

K

K

S

S

V

V

G

G

T

G

D

Q

P

P

L

I

F

V

I

F

E

D

K

R

A

V

S

K

G

D

S

A

R

Y

I

A

Y

W

D

D

V

V

D

D

G

G

N

N

E

R

F

Y

I

I

D

D

Y

Y

V

V

G

G

S

T

W

W

G

G

P

P

M

A

I

I

L

C

G

G

H

H

C

A

H

H

P

P

Q

E

V

V

V

I

A

E

A

A

V

L

K

K

S

V

A

A

V

M

D

E

N

K

G

G

C

T

S

S

F

F

G

G

A

A

P

P

T

C

E

A

L

L

E

E

I

N

T

V

L

L

A

A

E

E

M

M

V

V

I

N

E

D

A

A

V

V

P

P

S

S

I

I

E

E

M

M

V

V

R

R

M

F

V

V

S

N

S

S

G
|
G

T
|
T

E

E

A

A

T

C

M

M

S

A

A

V

I

L

R

R

L

L

A

M

R

R

G

A

Y

Y

T

T

G

G

R

R

D

D

K

K

I

I

L

I

K

K

F

F

S

E

G

G

C

C

Y
|
Y

H
|
H

G
|
G

H

H

S

A

D

D

S

M

L

F

L

L

V

V

K

K

A

A

G

G

S

S

G

G

A

V

A

A

T

T

F

L

G

G

V

L

P

P

D

S

S

S

P

P

G

G

V

V

P

P

Q

K

D

K

F

T

A

T

K

A

H

N

T

T

L

L

T

T

A

T

T

P

Y

Y

N

N

D

D

L

L

E

E

S

A

V

V

N

K

K

A

L

L

V

F

A

A

E

E

N

N

K

P

N

G

Q

E

I

I

S

A

C

G

I

V

I

I

V

L

E
|
E

P

P

V

I

A

V

G

G

N
|
N

M

S

G

G

T

F

V

I

P

V

P

P

R

D

E

A

G

G

F

F

L

L

E

E

G

G

L

L

R

R

S

E

L

I

C

T

T

L

E

E

E

H

G

D

I

A

V

L

L

L

I

V

F

F

D
|
D

E

E

V
|
V

M
|
M

S

T

G

G

F

F

R

R

V

I

A

A

Y

Y

G

G

G

G

A

V

Q

Q

E

E

L

K

Y

F

N

G

V

V

T

T

P

P

D

D

M

L

T

T

T

T

L

L

G

G

K
|
K

I

I

I

I

G

G

G

G

G

G

L

L

P

P

V

V

G

G

A

A

F

Y

G

G

G

G

K

K

K

R

E

E

I

I

M

M

S

Q

L

L

L

V

S

A

P

P

S

A

G

G

G

P

V

M

Y

Y

Q

Q

A

A

G

G

T

T

L

L

S

S

G

G

N

N

P

P

L

L

A

A

M

M

T

T

A

A

G

G

I

I

E

K

T

T

L

L

K

E

L

L

L

L

Q

R

T

Q

E

P

G

G

F

T

Y

Y

Q

E

D

Y

L

L

D

D

R

Q

K

I

S

T

D

K

Y

R

V

L

A

S

S

D

G

G

I

L

A

L

K

A

A

I

A

A

K

Q

D

E

A

T

G

G

F

H

P

A

I

A

Y

C

S

G

T

G

R

Q

V

V

G

S

S

G

M

M

F

F

C

G

A

F

F

F

F

F

S

T

K

E

K

G

P

P

V

V

Y

H

D

N

W

Y

T

E

S

D

A

A

A

K

A

K

C

S

D

D

T

L

K

Q

A

K

F

F

A

S

K

R

Y

F

F

H

R

R

L

G

M

M

L

L

D

E

E

Q

G

G

I

I

Y

Y

L

L

A

A

P

P

S

S

Q

Q

F

F

E

E

T
x
A

A

G

F

F

V

T

S

S

I

L

A

A

H

H

S

T

T

E

D

E

D

D

L

I

D

D

K

A

T

T

I

L

A

A

A

A

A

A

A

R

K

T

A

V

F

M

K

S

S

A

L

L

active site: V21 (= V21), Y144 (= Y144), E206 (= E206), D239 (= D239), M242 (= M242), K267 (= K267), A401 (≠ T401)
binding 4'-deoxy-4'-aminopyridoxal-5'-phosphate: G117 (= G117), T118 (= T118), Y144 (= Y144), H145 (= H145), G146 (= G146), N211 (= N211), D239 (= D239), V241 (= V241), K267 (= K267)

3usfA Crystal structure of dava-4
57% identity, 99% coverage: 5:427/427 of query aligns to 5:427/427 of 3usfA

query
sites
3usfA

R

K

S

S

E

D

L

E

L

I

F

F

Q

A

E

A

A

A

Q

Q

K

K

A

L

I

M

P

P

G

G

G

G

V
|
V

N

S

S
|
S

P

P

V
|
V

R

R

A

A

F

F

K

K

S

S

V

V

G

G

T

G

D

Q

P

P

L

I

F

V

I

F

E

D

K

R

A

V

S

K

G

D

S

A

R

Y

I

A

Y

W

D

D

V

V

D

D

G

G

N

N

E

R

F

Y

I

I

D

D

Y

Y

V

V

G

G

S

T

W

W

G

G

P

P

M

A

I

I

L

C

G

G

H

H

C

A

H

H

P

P

Q

E

V

V

V

I

A

E

A

A

V

L

K

K

S

V

A

A

V

M

D

E

N

K

G

G

C

T

S

S

F

F

G

G

A

A

P

P

T

C

E

A

L

L

E

E

I

N

T

V

L

L

A

A

E

E

M

M

V

V

I

N

E

D

A

A

V

V

P

P

S

S

I

I

E

E

M

M

V

V

R

R

M

F

V

V

S

N

S

S

G
|
G

T
|
T

E

E

A

A

T

C

M

M

S

A

A

V

I

L

R

R

L

I

A

M

R

R

G

A

Y

Y

T

T

G

G

R

R

D

D

K

K

I

I

L

I

K

K

F

F

S

E

G

G

C

C

Y
|
Y

H

H

G

G

H

H

S

A

D

D

S

M

L

F

L

L

V

V

K

K

A

A

G

G

S
|
S

G

G

A

V

A

A

T

T

F

L

G

G

V

L

P

P

D

S

S

S

P

P

G

G

V

V

P

P

Q

K

D

K

F

T

A

T

K

A

H

N

T

T

L

L

T

T

A

T

T

P

Y

Y

N

N

D

D

L

L

E

E

S

A

V

V

N

K

K

A

L

L

V

F

A

A

E

E

N

N

K

P

N

G

Q

E

I

I

S

A

C

G

I

V

I

I

V

L

E

E

P

P

V

I

A

V

G

G

N
|
N

M

S

G

G

T

F

V

I

P

V

P

P

R

D

E

A

G

G

F

F

L

L

E

E

G

G

L

L

R

R

S

E

L

I

C

T

T

L

E

E

E

H

G

D

I

A

V

L

L

L

I

V

F

F

D
|
D

E

E

V
|
V

M
|
M

S

T

G

G

F

F

R

R

V

I

A

A

Y

Y

G

G

G

G

A

V

Q

Q

E

E

L

K

Y

F

N

G

V

V

T

T

P

P

D

D

M

L

T

T

T

T

L

L

G

G

K
|
K

I

I

I

I

G

G

G

G

G

G

L

L

P

P

V

V

G

G

A

A

F

Y

G

G

G

G

K

K

K

R

E

E

I

I

M

M

S

Q

L

L

L

V

S

A

P

P

S

A

G

G

G

P

V

M

Y

Y

Q

Q

A

A

G

G

T

T

L

L

S

S

G