SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing WP_011969977.1 NCBI__GCF_000017145.1:WP_011969977.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

1d7vA Crystal structure of the complex of 2,2-dialkylglycine decarboxylase with nma (see paper)
70% identity, 95% coverage: 4:433/451 of query aligns to 2:431/431 of 1d7vA

query
sites
1d7vA

N

N

Q

D

D

D

P

A

A

T

F

F

W

W

A

R

A

N

A

A

G

R

R

Q

H

H

L

L

I

V

R

R

Y

Y

G
|
G

G

G

S

T

F

F

D

E

P

P

A

M

I

I

E

E

R

R

A

A

R

K

G

G

S

S

F

F

V

V

F

Y

D

D

A

A

D

D

D

G

R

R

P

A

I

I

L

L

D

D

F

F

T

T

S

S

G

G

Q

Q

M

M

S

S

A

A

L

V

V

L

G

G

H

H

S

C

H

H

P

P

R

E

I

I

V

V

A

S

T

V

V

I

Q

G

R

E

Q

Y

M

A

E

G

K

K

V

L

A

D

H
|
H

L
|
L

F
|
F

S
|
S

G

G

M

M

L

L

S

S

R

R

P

P

V

V

D

D

L

L

A

A

E

T

R

R

L

L

A

A

A

N

L

I

A

T

P

P

-

P

G

G

L

L

D

D

R

R

V

A

M

L

L

L

S

S

T

T

G

G

A
|
A

E

E

S

S

N

N

E

E

A

A

I

I

R

R

M

M

A

A

K

K

L

L

V

V

T

T

G

G

R

K

H

Y

E

E

I

I

V

V

A

G

F

F

S

A

K

Q

S

S

W
|
W

H
|
H

G

G

M

M

T

T

G

G

A

A

S

A

S

S

A

A

T

T

Y

Y

S

S

A

A

G

G

R

R

K

K

G

G

Y

V

G

G

P

P

A

A

M

A

V

V

G

G

S

S

L

F

T

A

I

I

P

P

A

A

P

P

N

F

T

T

F

Y

R

R

P

P

R

R

F

F

R

E

H

R

G

-

D

N

G

G

S

A

L

Y

D

D

W

Y

R

L

T

A

E

E

L

L

D

D

D

Y

A

A

F

F

A

D

L

L

I

I

D

D

S

R

Q

Q

S

S

T

S

G

G

S

N

L

L

A

A

F

F

I

I

A

A

E
|
E

P

P

I

I

L

L

S

S

S
|
S

G

G

L

I

E

E

L

L

P

P

Q

D

G

G

Y

Y

L

M

A

A

L

L

M

K

E

R

K

K

C

C

R

E

E

A

R

R

G

G

M

M

L

L

I

I

L

L

D
|
D

E

E

A
|
A

Q
|
Q

T

T

G

G

I

V

G

G

R

R

T

T

G

G

T

T

M

M

F

F

A

A

F

C

Q

Q

R

R

D

D

G

G

V

V

T

T

P

P

D

D

I

I

L

L

T

T

L

L

S

S

K
|
K

T

T

I

L

G

G

A

A

G

G

L

L

P

P

L

L

S

A

A

A

V

I

M

V

T

T

T

S

T

A

E

A

I

I

E

E

A

R

A

A

H

H

E

E

K

L

G

G

F

Y

L

L

F

F

Y

Y

T

T

T
|
T

H
|
H

V
|
V

S
|
S

D
|
D

P

P

L

L

P

P

A

A

V

V

G

G

L

L

A

R

V

V

L

L

D

D

V

V

A

Q

E

R

E

D

G

G

L

L

V

V

E

A

R

R

A

A

R

N

H

V

I

M

G

G

G

D

E

R

L

L

F

R

D

R

G

G

L

L

S

L

Q

D

L

L

K

M

Q

E

R

R

F

F

D

D

C

C

V

I

G

G

D

D

V

V

R

R

G

G

R

R

G

G

L

L

M

L

L

L

G

G

V

V

E

E

I

I

V

V

K

K

P

D

G

R

E

R

S

T

R

K

S

E

A

P

D

A

H

D

E

G

L

L

G

G

S

A

R

K

I

I

A

T

A

R

E

E

A

C

F

M

R

N

R

L

G

G

L

L

S

S

M

M

N

N

I

I

V

V

K

Q

L

L

P

P

G

G

M

M

G

G

V

V

F

F

R
|
R

I

I

A

A

P

P

L

L

T

T

I

V

S

S

E

E

E

D

E

E

I

I

E

D

L

L

G

G

L

L

R

S

I

L

T

G

Q

Q

S

A

I

I

E

E

A

R

S

A

L

L

active site: G19 (= G21), W136 (= W137), E208 (= E210), D241 (= D243), Q244 (= Q246), K270 (= K272), T301 (= T303), R404 (= R406)
binding potassium ion: H75 (= H77), L76 (= L78), F77 (= F79), S78 (= S80), T301 (= T303), H302 (= H304), V303 (= V305), S304 (= S306), D305 (= D307)
binding n-[3-hydroxy-2-methyl-5-phosphonooxymethyl-pyridin-4-ylmethyl]-2-methylalanine: A110 (= A111), W136 (= W137), H137 (= H138), E208 (= E210), S213 (= S215), D241 (= D243), A243 (= A245), Q244 (= Q246), K270 (= K272), R404 (= R406)

1d7uA Crystal structure of the complex of 2,2-dialkylglycine decarboxylase with lcs (see paper)
70% identity, 95% coverage: 4:433/451 of query aligns to 2:431/431 of 1d7uA

query
sites
1d7uA

N

N

Q

D

D

D

P

A

A

T

F

F

W

W

A

R

A

N

A

A

G

R

R

Q

H

H

L

L

I

V

R

R

Y

Y

G
|
G

G

G

S

T

F

F

D

E

P

P

A

M

I

I

E

E

R

R

A

A

R

K

G

G

S

S

F

F

V

V

F

Y

D

D

A

A

D

D

D

G

R

R

P

A

I

I

L

L

D

D

F

F

T

T

S

S

G

G

Q

Q

M

M

S

S

A

A

L

V

V

L

G

G

H

H

S

C

H

H

P

P

R

E

I

I

V

V

A

S

T

V

V

I

Q

G

R

E

Q

Y

M

A

E

G

K

K

V

L

A

D

H
|
H

L
|
L

F
|
F

S
|
S

G

G

M

M

L

L

S

S

R

R

P

P

V

V

D

D

L

L

A

A

E

T

R

R

L

L

A

A

A

N

L

I

A

T

P

P

-

P

G

G

L

L

D

D

R

R

V

A

M

L

L

L

S

S

T

T

G
|
G

A
|
A

E

E

S

S

N

N

E

E

A

A

I

I

R

R

M

M

A

A

K

K

L

L

V

V

T

T

G

G

R

K

H

Y

E

E

I

I

V

V

A

G

F

F

S

A

K

Q

S

S

W
|
W

H
|
H

G

G

M

M

T

T

G

G

A

A

S

A

S

S

A

A

T

T

Y

Y

S

S

A

A

G

G

R

R

K

K

G

G

Y

V

G

G

P

P

A

A

M

A

V

V

G

G

S

S

L

F

T

A

I

I

P

P

A

A

P

P

N

F

T

T

F

Y

R

R

P

P

R

R

F

F

R

E

H

R

G

-

D

N

G

G

S

A

L

Y

D

D

W

Y

R

L

T

A

E

E

L

L

D

D

D

Y

A

A

F

F

A

D

L

L

I

I

D

D

S

R

Q

Q

S

S

T

S

G

G

S

N

L

L

A

A

F

F

I

I

A

A

E
|
E

P

P

I

I

L

L

S

S

G

G

L

I

E

E

L

L

P

P

Q

D

G

G

Y

Y

L

M

A

A

L

L

M

K

E

R

K

K

C

C

R

E

E

A

R

R

G

G

M

M

L

L

I

I

L

L

D
|
D

E

E

A
|
A

Q
|
Q

T

T

G

G

I

V

G

G

R

R

T

T

G

G

T

T

M

M

F

F

A

A

F

C

Q

Q

R

R

D

D

G

G

V

V

T

T

P

P

D

D

I

I

L

L

T

T

L

L

S

S

K
|
K

T

T

I

L

G

G

A

A

G

G

L

L

P

P

L

L

S

A

A

A

V

I

M

V

T

T

T

S

T

A

E

A

I

I

E

E

A

R

A

A

H

H

E

E

K

L

G

G

F

Y

L

L

F

F

Y

Y

T

T

T
|
T

H
|
H

V
|
V

S
|
S

D
|
D

P

P

L

L

P

P

A

A

V

V

G

G

L

L

A

R

V

V

L

L

D

D

V

V

A

Q

E

R

E

D

G

G

L

L

V

V

E

A

R

R

A

A

R

N

H

V

I

M

G

G

G

D

E

R

L

L

F

R

D

R

G

G

L

L

S

L

Q

D

L

L

K

M

Q

E

R

R

F

F

D

D

C

C

V

I

G

G

D

D

V

V

R

R

G

G

R

R

G

G

L

L

M

L

L

L

G

G

V

V

E

E

I

I

V

V

K

K

P

D

G

R

E

R

S

T

R

K

S

E

A

P

D

A

H

D

E

G

L

L

G

G

S

A

R

K

I

I

A

T

A

R

E

E

A

C

F

M

R

N

R

L

G

G

L

L

S

S

M

M

N

N

I

I

V

V

K

Q

L

L

P

P

G

G

M

M

G

G

V

V

F

F

R
|
R

I

I

A

A

P

P

L

L

T

T

I

V

S

S

E

E

E

D

E

E

I

I

E

D

L

L

G

G

L

L

R

S

I

L

T

G

Q

Q

S

A

I

I

E

E

A

R

S

A

L

L

active site: G19 (= G21), W136 (= W137), E208 (= E210), D241 (= D243), Q244 (= Q246), K270 (= K272), T301 (= T303), R404 (= R406)
binding potassium ion: H75 (= H77), L76 (= L78), F77 (= F79), S78 (= S80), T301 (= T303), H302 (= H304), V303 (= V305), S304 (= S306), D305 (= D307)
binding [5-hydroxy-6-methyl-4-({[(4E)-3-oxo-1,2-oxazolidin-4-ylidene]amino}methyl)pyridin-3-yl]methyl dihydrogen phosphate: G109 (= G110), A110 (= A111), W136 (= W137), H137 (= H138), E208 (= E210), D241 (= D243), A243 (= A245), Q244 (= Q246), K270 (= K272), R404 (= R406)

1d7sA Crystal structure of the complex of 2,2-dialkylglycine decarboxylase with dcs (see paper)
70% identity, 95% coverage: 4:433/451 of query aligns to 2:431/431 of 1d7sA

query
sites
1d7sA

N

N

Q

D

D

D

P

A

A

T

F

F

W

W

A

R

A

N

A

A

G

R

R

Q

H

H

L

L

I

V

R

R

Y

Y

G
|
G

G

G

S

T

F

F

D

E

P

P

A

M

I

I

E

E

R

R

A

A

R

K

G

G

S

S

F

F

V

V

F

Y

D

D

A

A

D

D

D

G

R

R

P

A

I

I

L

L

D

D

F

F

T

T

S

S

G

G

Q
|
Q

M

M

S

S

A

A

L

V

V

L

G

G

H

H

S

C

H

H

P

P

R

E

I

I

V

V

A

S

T

V

V

I

Q

G

R

E

Q

Y

M

A

E

G

K

K

V

L

A

D

H
|
H

L
|
L

F
|
F

S
|
S

G

G

M

M

L

L

S

S

R

R

P

P

V

V

D

D

L

L

A

A

E

T

R

R

L

L

A

A

A

N

L

I

A

T

P

P

-

P

G

G

L

L

D

D

R

R

V

A

M

L

L

L

S

S

T

T

G
|
G

A
|
A

E

E

S

S

N

N

E

E

A

A

I

I

R

R

M

M

A

A

K

K

L

L

V

V

T

T

G

G

R

K

H

Y

E

E

I

I

V

V

A

G

F

F

S

A

K

Q

S

S

W
|
W

H
|
H

G

G

M

M

T

T

G

G

A

A

S

A

S

S

A

A

T

T

Y

Y

S

S

A

A

G

G

R

R

K

K

G

G

Y

V

G

G

P

P

A

A

M

A

V

V

G

G

S

S

L

F

T

A

I

I

P

P

A

A

P

P

N

F

T

T

F

Y

R

R

P

P

R

R

F

F

R

E

H

R

G

-

D

N

G

G

S

A

L

Y

D

D

W

Y

R

L

T

A

E

E

L

L

D

D

D

Y

A

A

F

F

A

D

L

L

I

I

D

D

S

R

Q

Q

S

S

T

S

G

G

S

N

L

L

A

A

F

F

I

I

A

A

E
|
E

P

P

I

I

L

L

S

S

G

G

L

I

E

E

L

L

P

P

Q

D

G

G

Y

Y

L

M

A

A

L

L

M

K

E

R

K

K

C

C

R

E

E

A

R

R

G

G

M

M

L

L

I

I

L

L

D
|
D

E

E

A
|
A

Q
|
Q

T

T

G

G

I

V

G

G

R

R

T

T

G

G

T

T

M

M

F

F

A

A

F

C

Q

Q

R

R

D

D

G

G

V

V

T

T

P

P

D

D

I

I

L

L

T

T

L

L

S

S

K
|
K

T

T

I

L

G

G

A

A

G

G

L

L

P

P

L

L

S

A

A

A

V

I

M

V

T

T

T

S

T

A

E

A

I

I

E

E

A

R

A

A

H

H

E

E

K

L

G

G

F

Y

L

L

F

F

Y

Y

T

T

T
|
T

H
|
H

V
|
V

S
|
S

D
|
D

P

P

L

L

P

P

A

A

V

V

G

G

L

L

A

R

V

V

L

L

D

D

V

V

A

Q

E

R

E

D

G

G

L

L

V

V

E

A

R

R

A

A

R

N

H

V

I

M

G

G

G

D

E

R

L

L

F

R

D

R

G

G

L

L

S

L

Q

D

L

L

K

M

Q

E

R

R

F

F

D

D

C

C

V

I

G

G

D

D

V

V

R

R

G

G

R

R

G

G

L

L

M

L

L

L

G

G

V

V

E

E

I

I

V

V

K

K

P

D

G

R

E

R

S

T

R

K

S

E

A

P

D

A

H

D

E

G

L

L

G

G

S

A

R

K

I

I

A

T

A

R

E

E

A

C

F

M

R

N

R

L

G

G

L

L

S

S

M

M

N

N

I

I

V

V

K

Q

L

L

P

P

G

G

M

M

G

G

V

V

F

F

R
|
R

I

I

A

A

P

P

L

L

T

T

I

V

S

S

E

E

E

D

E

E

I

I

E

D

L

L

G

G

L

L

R

S

I

L

T

G

Q

Q

S

A

I

I

E

E

A

R

S

A

L

L

active site: G19 (= G21), W136 (= W137), E208 (= E210), D241 (= D243), Q244 (= Q246), K270 (= K272), T301 (= T303), R404 (= R406)
binding d-[3-hydroxy-2-methyl-5-phosphonooxymethyl-pyridin-4-ylmethyl]-n,o-cycloserylamide: Q50 (= Q52), G109 (= G110), A110 (= A111), W136 (= W137), H137 (= H138), E208 (= E210), D241 (= D243), A243 (= A245), Q244 (= Q246), K270 (= K272), R404 (= R406)
binding potassium ion: H75 (= H77), L76 (= L78), F77 (= F79), S78 (= S80), T301 (= T303), H302 (= H304), V303 (= V305), S304 (= S306), D305 (= D307)

1d7rA Crystal structure of the complex of 2,2-dialkylglycine decarboxylase with 5pa (see paper)
70% identity, 95% coverage: 4:433/451 of query aligns to 2:431/431 of 1d7rA

query
sites
1d7rA

N

N

Q

D

D

D

P

A

A

T

F

F

W

W

A

R

A

N

A

A

G

R

R

Q

H

H

L

L

I

V

R

R

Y

Y

G
|
G

G

G

S

T

F

F

D

E

P

P

A

M

I

I

E

E

R

R

A

A

R

K

G

G

S

S

F

F

V

V

F

Y

D

D

A

A

D

D

D

G

R

R

P

A

I

I

L

L

D

D

F

F

T

T

S

S

G

G

Q

Q

M

M

S

S

A

A

L

V

V

L

G

G

H

H

S

C

H

H

P

P

R

E

I

I

V

V

A

S

T

V

V

I

Q

G

R

E

Q

Y

M

A

E

G

K

K

V

L

A

D

H
|
H

L
|
L

F
|
F

S
|
S

G

G

M

M

L

L

S

S

R

R

P

P

V

V

D

D

L

L

A

A

E

T

R

R

L

L

A

A

A

N

L

I

A

T

P

P

-

P

G

G

L

L

D

D

R

R

V

A

M

L

L

L

S

S

T

T

G
|
G

A
|
A

E

E

S

S

N

N

E

E

A

A

I

I

R

R

M

M

A

A

K

K

L

L

V

V

T

T

G

G

R

K

H

Y

E

E

I

I

V

V

A

G

F

F

S

A

K

Q

S

S

W
|
W

H
|
H

G

G

M

M

T

T

G

G

A

A

S

A

S

S

A

A

T

T

Y

Y

S

S

A

A

G

G

R

R

K

K

G

G

Y

V

G

G

P

P

A

A

M

A

V

V

G

G

S

S

L

F

T

A

I

I

P

P

A

A

P

P

N

F

T

T

F

Y

R

R

P

P

R

R

F

F

R

E

H

R

G

-

D

N

G

G

S

A

L

Y

D

D

W

Y

R

L

T

A

E

E

L

L

D

D

D

Y

A

A

F

F

A

D

L

L

I

I

D

D

S

R

Q

Q

S

S

T

S

G

G

S

N

L

L

A

A

F

F

I

I

A

A

E
|
E

P

P

I

I

L

L

S

S

S
|
S

G

G

L

I

E

E

L

L

P

P

Q

D

G

G

Y

Y

L

M

A

A

L

L

M

K

E

R

K

K

C

C

R

E

E

A

R

R

G

G

M

M

L

L

I

I

L

L

D
|
D

E

E

A
|
A

Q
|
Q

T

T

G

G

I

V

G

G

R

R

T

T

G

G

T

T

M

M

F

F

A

A

F

C

Q

Q

R

R

D

D

G

G

V

V

T

T

P

P

D

D

I

I

L

L

T

T

L

L

S

S

K
|
K

T

T

I

L

G

G

A

A

G

G

L

L

P

P

L

L

S

A

A

A

V

I

M

V

T

T

T

S

T

A

E

A

I

I

E

E

A

R

A

A

H

H

E

E

K

L

G

G

F

Y

L

L

F

F

Y

Y

T

T

T
|
T

H
|
H

V
|
V

S
|
S

D
|
D

P

P

L

L

P

P

A

A

V

V

G

G

L

L

A

R

V

V

L

L

D

D

V

V

A

Q

E

R

E

D

G

G

L

L

V

V

E

A

R

R

A

A

R

N

H

V

I

M

G

G

G

D

E

R

L

L

F

R

D

R

G

G

L

L

S

L

Q

D

L

L

K

M

Q

E

R

R

F

F

D

D

C

C

V

I

G

G

D

D

V

V

R

R

G

G

R

R

G

G

L

L

M

L

L

L

G

G

V

V

E

E

I

I

V

V

K

K

P

D

G

R

E

R

S

T

R

K

S

E

A

P

D

A

H

D

E

G

L

L

G

G

S

A

R

K

I

I

A

T

A

R

E

E

A

C

F

M

R

N

R

L

G

G

L

L

S

S

M

M

N

N

I

I

V

V

K

Q

L

L

P

P

G

G

M

M

G

G

V

V

F

F

R
|
R

I

I

A

A

P

P

L

L

T

T

I

V

S

S

E

E

E

D

E

E

I

I

E

D

L

L

G

G

L

L

R

S

I

L

T

G

Q

Q

S

A

I

I

E

E

A

R

S

A

L

L

active site: G19 (= G21), W136 (= W137), E208 (= E210), D241 (= D243), Q244 (= Q246), K270 (= K272), T301 (= T303), R404 (= R406)
binding n-[3-hydroxy-2-methyl-5-phosphonooxymethyl-pyridin-4-y-lmethyl]-1-amino-cyclopropanecarboxylic acid: G109 (= G110), A110 (= A111), W136 (= W137), H137 (= H138), E208 (= E210), S213 (= S215), D241 (= D243), A243 (= A245), Q244 (= Q246), K270 (= K272), R404 (= R406)
binding potassium ion: H75 (= H77), L76 (= L78), F77 (= F79), S78 (= S80), T301 (= T303), H302 (= H304), V303 (= V305), S304 (= S306), D305 (= D307)

1dgdA An alkali metal ion size-dependent switch in the active site structure of dialkylglycine decarboxylase (see paper)
70% identity, 95% coverage: 4:433/451 of query aligns to 2:431/431 of 1dgdA

query
sites
1dgdA

N

N

Q

D

D

D

P

A

A

T

F

F

W

W

A

R

A

N

A

A

G

R

R

H

H

H

L

L

I

V

R

R

Y

Y

G
|
G

G

G

S

T

F

F

D

E

P

P

A

M

I

I

E

E

R

R

A

A

R

K

G

G

S

S

F

F

V

V

F

Y

D

D

A

A

D

D

D

G

R

R

P

A

I

I

L

L

D

D

F

F

T

T

S

S

G

G

Q

Q

M

M

S

S

A

A

L

V

V

L

G

G

H

H

S

C

H

H

P

P

R

E

I

I

V

V

A

S

T

V

V

I

Q

G

R

E

Q

Y

M

A

E

G

K

K

V

L

A

D

H

H

L

L

F

F

S

S

G

G

M

M

L

L

S

S

R

R

P

P

V

V

D

D

L

L

A

A

E

T

R

R

L

L

A

A

A

N

L

I

A

T

P

P

-

P

G

G

L

L

D

D

R

R

V

A

M

L

L

L

S

S

T
|
T

G
|
G

A
|
A

E

E

S

S

N

N

E

E

A

A

I

I

R

R

M

M

A

A

K

K

L

L

V

V

T

T

G

G

R

K

H

Y

E

E

I

I

V

V

A

G

F

F

S

A

K

Q

S

S

W
|
W

H
|
H

G

G

M

M

T

T

G

G

A

A

S

A

S

S

A

A

T

T

Y

Y

S

S

A

A

G

G

R

R

K

K

G

G

Y

V

G

G

P

P

A

A

M

A

V

V

G

G

S

S

L

F

T

A

I

I

P

P

A

A

P

P

N

F

T

T

F

Y

R

R

P

P

R

R

F

F

R

E

H

R

G

-

D

N

G

G

S

A

L

Y

D

D

W

Y

R

L

T

A

E

E

L

L

D

D

D

Y

A

A

F

F

A

D

L

L

I

I

D

D

S

R

Q

Q

S

S

T

S

G

G

S

N

L

L

A

A

F

F

I

I

A

A

E
|
E

P

P

I

I

L

L

S

S

G

G

L

I

E

E

L

L

P

P

Q

D

G

G

Y

Y

L

M

A

A

L

L

M

K

E

R

K

K

C

C

R

E

E

A

R

R

G

G

M

M

L

L

I

I

L

L

D
|
D

E

E

A
|
A

Q
|
Q

T

T

G

G

I

V

G

G

R

R

T

T

G

G

T

T

M

M

F

F

A

A

F

C

Q

Q

R

R

D

D

G

G

V

V

T

T

P

P

D

D

I

I

L

L

T

T

L

L

S

S

K
|
K

T

T

I

L

G

G

A

A

G

G

L

L

P

P

L

L

S

A

A

A

V

I

M

V

T

T

T

S

T

A

E

A

I

I

E

E

A

R

A

A

H

H

E

E

K

L

G

G

F

Y

L

L

F

F

Y

Y

T

T

T
|
T

H

H

V

V

S

S

D

D

P

P

L

L

P

P

A

A

V

V

G

G

L

L

A

R

V

V

L

L

D

D

V

V

A

Q

E

R

E

D

G

G

L

L

V

V

E

A

R

R

A

A

R

N

H

V

I

M

G

G

G

D

E

R

L

L

F

R

D

R

G

G

L

L

S

L

Q

D

L

L

K

M

Q

E

R

R

F

F

D

D

C

C

V

I

G

G

D

D

V

V

R

R

G

G

R

R

G

G

L

L

M

L

L

L

G

G

V

V

E

E

I

I

V

V

K

K

P

D

G

R

E

R

S

T

R

K

S

E

A

P

D

A

H

D

E

G

L

L

G

G

S

A

R

K

I

I

A

T

A

R

E

E

A

C

F

M

R

N

R

L

G

G

L

L

S

S

M

M

N

N

I

I

V

V

K

Q

L

L

P

P

G

G

M

M

G

G

V

V

F

F

R
|
R

I

I

A

A

P

P

L

L

T

T

I

V

S

S

E

E

E

D

E

E

I

I

E

D

L

L

G

G

L

L

R

S

I

L

T

G

Q

Q

S

A

I

I

E

E

A

R

S

A

L

L

active site: G19 (= G21), W136 (= W137), E208 (= E210), D241 (= D243), Q244 (= Q246), K270 (= K272), T301 (= T303), R404 (= R406)
binding pyridoxal-5'-phosphate: T108 (= T109), G109 (= G110), A110 (= A111), W136 (= W137), H137 (= H138), E208 (= E210), D241 (= D243), A243 (= A245), Q244 (= Q246), K270 (= K272)

1zobA Crystal structure of dialkylglycine decarboxylases bound with calcium ion
70% identity, 95% coverage: 4:433/451 of query aligns to 2:431/431 of 1zobA

query
sites
1zobA

N

N

Q

D

D

D

P

A

A

T

F

F

W

W

A

R

A

N

A

A

G

R

R

H

H

H

L

L

I

V

R

R

Y

Y

G
|
G

G

G

S

T

F

F

D

E

P

P

A

M

I

I

E

E

R

R

A

A

R

K

G

G

S

S

F

F

V

V

F

Y

D

D

A

A

D

D

D

G

R

R

P

A

I

I

L

L

D

D

F

F

T

T

S

S

G

G

Q

Q

M

M

S

S

A

A

L

V

V

L

G

G

H

H

S

C

H

H

P

P

R

E

I

I

V

V

A

S

T

V

V

I

Q

G

R

E

Q

Y

M

A

E

G

K

K

V

L

A

D

H

H

L
|
L

F

F

S
|
S

G

E

M

M

L

L

S

S

R

R

P

P

V

V

D

D

L

L

A

A

E

T

R

R

L

L

A

A

A

N

L

I

A

T

P

P

-

P

G

G

L

L

D

D

R

R

V

A

M

L

L

L

S

S

T
|
T

G

G

A
|
A

E

E

S

S

N
|
N

E

E

A

A

I

I

R

R

M

M

A

A

K

K

L

L

V

V

T

T

G

G

R

K

H

Y

E

E

I

I

V

V

A

G

F

F

S

A

K

Q

S

S

W
|
W

H
|
H

G

G

M

M

T

T

G

G

A

A

S

A

S

S

A

A

T

T

Y

Y

S

S

A

A

G

G

R

R

K

K

G

G

Y

V

G

G

P

P

A

A

M

A

V

V

G

G

S

S

L

F

T

A

I

I

P

P

A

A

P

P

N

F

T

T

F

Y

R

R

P

P

R

R

F

F

R

E

H

R

G

-

D

N

G

G

S

A

L

Y

D

D

W

Y

R

L

T

A

E

E

L

L

D

D

D

Y

A

A

F

F

A

D

L

L

I

I

D

D

S

R

Q

Q

S

S

T

S

G

G

S

N

L

L

A

A

F

F

I

I

A

A

E
|
E

P

P

I

I

L

L

S

S

G

G

L

I

E

E

L

L

P

P

Q

D

G

G

Y

Y

L

M

A

A

L

L

M

K

E

R

K

K

C

C

R

E

E

A

R

R

G

G

M

M

L

L

I

I

L

L

D
|
D

E

E

A
|
A

Q
|
Q

T

T

G

G

I

V

G

G

R

R

T

T

G

G

T

T

M

M

F

F

A

A

F

C

Q

Q

R

R

D

D

G

G

V

V

T

T

P

P

D

D

I

I

L

L

T

T

L

L

S

S

K
|
K

T

T

I

L

G

G

A

A

G

G

L

L

P

P

L

L

S

A

A

A

V

I

M

V

T

T

T

S

T

A

E

A

I

I

E

E

A

R

A

A

H

H

E

E

K

L

G

G

F

Y

L

L

F

F

Y

Y

T

T

T
|
T

H

H

V
|
V

S
|
S

D
|
D

P

P

L

L

P

P

A

A

V

V

G

G

L

L

A

R

V

V

L

L

D

D

V

V

A

Q

E

R

E

D

G

G

L

L

V

V

E

A

R

R

A

A

R

N

H

V

I

M

G

G

G

D

E

R

L

L

F

R

D

R

G

G

L

L

S

L

Q

D

L

L

K

M

Q

E

R

R

F

F

D

D

C

C

V

I

G

G

D

D

V

V

R

R

G

G

R

R

G

G

L

L

M

L

L

L

G

G

V

V

E

E

I

I

V

V

K

K

P

D

G

R

E

R

S

T

R

K

S

E

A

P

D

A

H

D

E

G

L

L

G

G

S

A

R

K

I

I

A

T

A

R

E

E

A

C

F

M

R

N

R

L

G

G

L

L

S

S

M

M

N

N

I

I

V

V

K

Q

L

L

P

P

G

G

M

M

G

G

V

V

F

F

R
|
R

I

I

A

A

P

P

L

L

T

T

I

V

S

S

E

E

E

D

E

E

I

I

E

D

L

L

G

G

L

L

R

S

I

L

T

G

Q

Q

S

A

I

I

E

E

A

R

S

A

L

L

active site: G19 (= G21), W136 (= W137), E208 (= E210), D241 (= D243), Q244 (= Q246), K270 (= K272), T301 (= T303), R404 (= R406)
binding calcium ion: L76 (= L78), S78 (= S80), V303 (= V305), S304 (= S306), D305 (= D307)
binding pyridoxal-5'-phosphate: T108 (= T109), A110 (= A111), N113 (= N114), W136 (= W137), H137 (= H138), E208 (= E210), D241 (= D243), A243 (= A245), Q244 (= Q246), K270 (= K272)

1zc9A The crystal structure of dialkylglycine decarboxylase complex with pyridoxamine 5-phosphate (see paper)
70% identity, 95% coverage: 4:433/451 of query aligns to 2:431/431 of 1zc9A

query
sites
1zc9A

N

N

Q

D

D

D

P

A

A

T

F

F

W

W

A

R

A

N

A

A

G

R

R

H

H

H

L

L

I

V

R

R

Y

Y

G
|
G

G

G

S

T

F

F

D

E

P

P

A

M

I

I

E

E

R

R

A

A

R

K

G

G

S

S

F

F

V

V

F

Y

D

D

A

A

D

D

D

G

R

R

P

A

I

I

L

L

D

D

F

F

T

T

S

S

G

G

Q

Q

M

M

S

S

A

A

L

V

V

L

G

G

H

H

S

C

H

H

P

P

R

E

I

I

V

V

A

S

T

V

V

I

Q

G

R

E

Q

Y

M

A

E

G

K

K

V

L

A

D

H

H

L

L

F

F

S

S

G

E

M

M

L

L

S

S

R

R

P

P

V

V

D

D

L

L

A

A

E

T

R

R

L

L

A

A

A

N

L

I

A

T

P

P

-

P

G

G

L

L

D

D

R

R

V

A

M

L

L

L

S

S

T

T

G
|
G

A
|
A

E

E

S

S

N

N

E

E

A

A

I

I

R

R

M

M

A

A

K

K

L

L

V

V

T

T

G

G

R

K

H

Y

E

E

I

I

V

V

A

G

F

F

S

A

K

Q

S

S

W
|
W

H
|
H

G

G

M

M

T

T

G

G

A

A

S

A

S

S

A

A

T

T

Y

Y

S

S

A

A

G

G

R

R

K

K

G

G

Y

V

G

G

P

P

A

A

M

A

V

V

G

G

S

S

L

F

T

A

I

I

P

P

A

A

P

P

N

F

T

T

F

Y

R

R

P

P

R

R

F

F

R

E

H

R

G

-

D

N

G

G

S

A

L

Y

D

D

W

Y

R

L

T

A

E

E

L

L

D

D

D

Y

A

A

F

F

A

D

L

L

I

I

D

D

S

R

Q

Q

S

S

T

S

G

G

S

N

L

L

A

A

F

F

I

I

A

A

E
|
E

P

P

I

I

L

L

S

S

G

G

L

I

E

E

L

L

P

P

Q

D

G

G

Y

Y

L

M

A

A

L

L

M

K

E

R

K

K

C

C

R

E

E

A

R

R

G

G

M

M

L

L

I

I

L

L

D
|
D

E

E

A
|
A

Q
|
Q

T

T

G

G

I

V

G

G

R

R

T

T

G

G

T

T

M

M

F

F

A

A

F

C

Q

Q

R

R

D

D

G

G

V

V

T

T

P

P

D

D

I

I

L

L

T

T

L

L

S

S

K
|
K

T

T

I

L

G

G

A

A

G

G

L

L

P

P

L

L

S

A

A

A

V

I

M

V

T

T

T

S

T

A

E

A

I

I

E

E

A

R

A

A

H

H

E

E

K

L

G

G

F

Y

L

L

F

F

Y

Y

T

T

T
|
T

H

H

V

V

S

S

D

D

P

P

L

L

P

P

A

A

V

V

G

G

L

L

A

R

V

V

L

L

D

D

V

V

A

Q

E

R

E

D

G

G

L

L

V

V

E

A

R

R

A

A

R

N

H

V

I

M

G

G

G

D

E

R

L

L

F

R

D

R

G

G

L

L

S

L

Q

D

L

L

K

M

Q

E

R

R

F

F

D

D

C

C

V

I

G

G

D

D

V

V

R

R

G

G

R

R

G

G

L

L

M

L

L

L

G

G

V

V

E

E

I

I

V

V

K

K

P

D

G

R

E

R

S

T

R

K

S

E

A

P

D

A

H

D

E

G

L

L

G

G

S

A

R

K

I

I

A

T

A

R

E

E

A

C

F

M

R

N

R

L

G

G

L

L

S

S

M

M

N

N

I

I

V

V

K

Q

L

L

P

P

G

G

M

M

G

G

V

V

F

F

R
|
R

I

I

A

A

P

P

L

L

T

T

I

V

S

S

E

E

E

D

E

E

I

I

E

D

L

L

G

G

L

L

R

S

I

L

T

G

Q

Q

S

A

I

I

E

E

A

R

S

A

L

L

active site: G19 (= G21), W136 (= W137), E208 (= E210), D241 (= D243), Q244 (= Q246), K270 (= K272), T301 (= T303), R404 (= R406)
binding 4'-deoxy-4'-aminopyridoxal-5'-phosphate: G109 (= G110), A110 (= A111), W136 (= W137), H137 (= H138), E208 (= E210), D241 (= D243), A243 (= A245), Q244 (= Q246), K270 (= K272)

1m0qA Structure of dialkylglycine decarboxylase complexed with s-1- aminoethanephosphonate (see paper)
70% identity, 95% coverage: 4:433/451 of query aligns to 2:431/431 of 1m0qA

query
sites
1m0qA

N

N

Q

D

D

D

P

A

A

T

F

F

W

W

A

R

A

N

A

A

G

R

R

H

H

H

L

L

I

V

R

R

Y

Y

G
|
G

G

G

S

T

F

F

D

E

P

P

A

M

I

I

E

E

R

R

A

A

R

K

G

G

S

S

F

F

V

V

F

Y

D

D

A

A

D

D

D

G

R

R

P

A

I

I

L

L

D

D

F

F

T

T

S

S

G

G

Q
|
Q

M

M

S

S

A

A

L

V

V

L

G

G

H

H

S

C

H

H

P

P

R

E

I

I

V

V

A

S

T

V

V

I

Q

G

R

E

Q

Y

M

A

E

G

K

K

V

L

A

D

H

H

L

L

F

F

S

S

G

E

M

M

L

L

S

S

R

R

P

P

V

V

D

D

L

L

A

A

E

T

R

R

L

L

A

A

A

N

L

I

A

T

P

P

-

P

G

G

L

L

D

D

R

R

V

A

M

L

L

L

S

S

T
|
T

G

G

A
|
A

E

E

S

S

N

N

E

E

A

A

I

I

R

R

M

M

A

A

K

K

L

L

V

V

T

T

G

G

R

K

H

Y

E

E

I

I

V

V

A

G

F

F

S

A

K

Q

S

S

W
|
W

H
|
H

G

G

M

M

T

T

G

G

A

A

S

A

S

S

A

A

T

T

Y

Y

S

S

A

A

G

G

R

R

K

K

G

G

Y

V

G

G

P

P

A

A

M

A

V

V

G

G

S

S

L

F

T

A

I

I

P

P

A

A

P

P

N

F

T

T

F

Y

R

R

P

P

R

R

F

F

R

E

H

R

G

-

D

N

G

G

S

A

L

Y

D

D

W

Y

R

L

T

A

E

E

L

L

D

D

D

Y

A

A

F

F

A

D

L

L

I

I

D

D

S

R

Q

Q

S

S

T

S

G

G

S

N

L

L

A

A

F

F

I

I

A

A

E
|
E

P

P

I

I

L

L

S

S

S
|
S

G

G

L

I

E

E

L

L

P

P

Q

D

G

G

Y

Y

L

M

A

A

L

L

M

K

E

R

K

K

C

C

R

E

E

A

R

R

G

G

M

M

L

L

I

I

L

L

D
|
D

E

E

A
|
A

Q
|
Q

T

T

G

G

I

V

G

G

R

R

T

T

G

G

T

T

M

M

F

F

A

A

F

C

Q

Q

R

R

D

D

G

G

V

V

T

T

P

P

D

D

I

I

L

L

T

T

L

L

S

S

K
|
K

T

T

I

L

G

G

A

A

G

G

L

L

P

P

L

L

S

A

A

A

V

I

M

V

T

T

T

S

T

A

E

A

I

I

E

E

A

R

A

A

H

H

E

E

K

L

G

G

F

Y

L

L

F

F

Y

Y

T

T

T
|
T

H

H

V

V

S

S

D

D

P

P

L

L

P

P

A

A

V

V

G

G

L

L

A

R

V

V

L

L

D

D

V

V

A

Q

E

R

E

D

G

G

L

L

V

V

E

A

R

R

A

A

R

N

H

V

I

M

G

G

G

D

E

R

L

L

F

R

D

R

G

G

L

L

S

L

Q

D

L

L

K

M

Q

E

R

R

F

F

D

D

C

C

V

I

G

G

D

D

V

V

R

R

G

G

R

R

G

G

L

L

M

L

L

L

G

G

V

V

E

E

I

I

V

V

K

K

P

D

G

R

E

R

S

T

R

K

S

E

A

P

D

A

H

D

E

G

L

L

G

G

S

A

R

K

I

I

A

T

A

R

E

E

A

C

F

M

R

N

R

L

G

G

L

L

S

S

M

M

N

N

I

I

V

V

K

Q

L

L

P

P

G

G

M

M

G

G

V

V

F

F

R
|
R

I

I

A

A

P

P

L

L

T

T

I

V

S

S

E

E

E

D

E

E

I

I

E

D

L

L

G

G

L

L

R

S

I

L

T

G

Q

Q

S

A

I

I

E

E

A

R

S

A

L

L

active site: G19 (= G21), W136 (= W137), E208 (= E210), D241 (= D243), Q244 (= Q246), K270 (= K272), T301 (= T303), R404 (= R406)
binding (1s)-1-[((1e)-{3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylene)amino]ethylphosphonic acid: Q50 (= Q52), T108 (= T109), A110 (= A111), W136 (= W137), H137 (= H138), E208 (= E210), S213 (= S215), D241 (= D243), A243 (= A245), Q244 (= Q246), K270 (= K272), R404 (= R406)

1m0pA Structure of dialkylglycine decarboxylase complexed with 1-amino-1- phenylethanephosphonate (see paper)
70% identity, 95% coverage: 4:433/451 of query aligns to 2:431/431 of 1m0pA

query
sites
1m0pA

N

N

Q

D

D

D

P

A

A

T

F

F

W

W

A

R

A

N

A

A

G

R

R

H

H

H

L

L

I

V

R

R

Y

Y

G
|
G

G

G

S

T

F

F

D

E

P

P

A

M

I

I

E

E

R

R

A

A

R

K

G

G

S

S

F

F

V

V

F

Y

D

D

A

A

D

D

D

G

R

R

P

A

I

I

L

L

D

D

F

F

T

T

S

S

G

G

Q
|
Q

M

M

S

S

A

A

L

V

V

L

G

G

H

H

S

C

H

H

P

P

R

E

I

I

V

V

A

S

T

V

V

I

Q

G

R

E

Q

Y

M

A

E

G

K

K

V

L

A

D

H

H

L

L

F

F

S

S

G

E

M

M

L

L

S

S

R

R

P

P

V

V

D

D

L

L

A

A

E

T

R

R

L

L

A

A

A

N

L

I

A

T

P

P

-

P

G

G

L

L

D

D

R

R

V

A

M

L

L

L

S

S

T
|
T

G

G

A
|
A

E

E

S

S

N

N

E

E

A

A

I

I

R

R

M

M

A

A

K

K

L

L

V

V

T

T

G

G

R

K

H

Y

E

E

I

I

V

V

A

G

F

F

S

A

K

Q

S

S

W
|
W

H
|
H

G

G

M

M

T

T

G

G

A

A

S

A

S

S

A

A

T

T

Y

Y

S

S

A

A

G

G

R

R

K

K

G

G

Y

V

G

G

P

P

A

A

M

A

V

V

G

G

S

S

L

F

T

A

I

I

P

P

A

A

P

P

N

F

T

T

F

Y

R

R

P

P

R

R

F

F

R

E

H

R

G

-

D

N

G

G

S

A

L

Y

D

D

W

Y

R

L

T

A

E

E

L

L

D

D

D

Y

A

A

F

F

A

D

L

L

I

I

D

D

S

R

Q

Q

S

S

T

S

G

G

S

N

L

L

A

A

F

F

I

I

A

A

E
|
E

P

P

I

I

L

L

S

S

S
|
S

G

G

L

I

E

E

L

L

P

P

Q

D

G

G

Y

Y

L

M

A

A

L

L

M

K

E

R

K

K

C

C

R

E

E

A

R

R

G

G

M

M

L

L

I

I

L

L

D
|
D

E

E

A
|
A

Q
|
Q

T

T

G

G

I

V

G

G

R

R

T

T

G

G

T

T

M

M

F

F

A

A

F

C

Q

Q

R

R

D

D

G

G

V

V

T

T

P

P

D

D

I

I

L

L

T

T

L

L

S

S

K
|
K

T

T

I

L

G

G

A

A

G

G

L

L

P

P

L

L

S

A

A

A

V

I

M

V

T

T

T

S

T

A

E

A

I

I

E

E

A

R

A

A

H

H

E

E

K

L

G

G

F

Y

L

L

F

F

Y

Y

T

T

T
|
T

H

H

V

V

S

S

D

D

P

P

L

L

P

P

A

A

V

V

G

G

L

L

A

R

V

V

L

L

D

D

V

V

A

Q

E

R

E

D

G

G

L

L

V

V

E

A

R

R

A

A

R

N

H

V

I

M

G

G

G

D

E

R

L

L

F

R

D

R

G

G

L

L

S

L

Q

D

L

L

K

M

Q

E

R

R

F

F

D

D

C

C

V

I

G

G

D

D

V

V

R

R

G

G

R

R

G

G

L

L

M

L

L

L

G

G

V

V

E

E

I

I

V

V

K

K

P

D

G

R

E

R

S

T

R

K

S

E

A

P

D

A

H

D

E

G

L

L

G

G

S

A

R

K

I

I

A

T

A

R

E

E

A

C

F

M

R

N

R

L

G

G

L

L

S

S

M

M

N

N

I

I

V

V

K

Q

L

L

P

P

G

G

M

M

G

G

V

V

F

F

R
|
R

I

I

A

A

P

P

L

L

T

T

I

V

S

S

E

E

E

D

E

E

I

I

E

D

L

L

G

G

L

L

R

S

I

L

T

G

Q

Q

S

A

I

I

E

E

A

R

S

A

L

L

active site: G19 (= G21), W136 (= W137), E208 (= E210), D241 (= D243), Q244 (= Q246), K270 (= K272), T301 (= T303), R404 (= R406)
binding (1r)-1-[((1e)-{3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylene)amino]-1-phenylethylphosphonic acid: Q50 (= Q52), T108 (= T109), A110 (= A111), W136 (= W137), H137 (= H138), E208 (= E210), S213 (= S215), D241 (= D243), A243 (= A245), Q244 (= Q246), K270 (= K272), R404 (= R406)

1m0oA Structure of dialkylglycine decarboxylase complexed with 1-amino-1- methylpropanephosphonate (see paper)
70% identity, 95% coverage: 4:433/451 of query aligns to 2:431/431 of 1m0oA

query
sites
1m0oA

N

N

Q

D

D

D

P

A

A

T

F

F

W

W

A

R

A

N

A

A

G

R

R

H

H

H

L

L

I

V

R

R

Y

Y

G
|
G

G

G

S

T

F

F

D

E

P

P

A

M

I

I

E

E

R

R

A

A

R

K

G

G

S

S

F

F

V

V

F

Y

D

D

A

A

D

D

D

G

R

R

P

A

I

I

L

L

D

D

F

F

T

T

S

S

G

G

Q
|
Q

M

M

S

S

A

A

L

V

V

L

G

G

H

H

S

C

H

H

P

P

R

E

I

I

V

V

A

S

T

V

V

I

Q

G

R

E

Q

Y

M

A

E

G

K

K

V

L

A

D

H

H

L

L

F

F

S

S

G

E

M

M

L

L

S

S

R

R

P

P

V

V

D

D

L

L

A

A

E

T

R

R

L

L

A

A

A

N

L

I

A

T

P

P

-

P

G

G

L

L

D

D

R

R

V

A

M

L

L

L

S

S

T

T

G
|
G

A
|
A

E

E

S

S

N

N

E

E

A

A

I

I

R

R

M

M

A

A

K

K

L

L

V

V

T

T

G

G

R

K

H

Y

E

E

I

I

V

V

A

G

F

F

S

A

K

Q

S

S

W
|
W

H
|
H

G

G

M

M

T

T

G

G

A

A

S

A

S

S

A

A

T

T

Y

Y

S

S

A

A

G

G

R

R

K

K

G

G

Y

V

G

G

P

P

A

A

M

A

V

V

G

G

S

S

L

F

T

A

I

I

P

P

A

A

P

P

N

F

T

T

F

Y

R

R

P

P

R

R

F

F

R

E

H

R

G

-

D

N

G

G

S

A

L

Y

D

D

W

Y

R

L

T

A

E

E

L

L

D

D

D

Y

A

A

F

F

A

D

L

L

I

I

D

D

S

R

Q

Q

S

S

T

S

G

G

S

N

L

L

A

A

F

F

I

I

A

A

E
|
E

P

P

I

I

L

L

S

S

G

G

L

I

E

E

L

L

P

P

Q

D

G

G

Y

Y

L

M

A

A

L

L

M

K

E

R

K

K

C

C

R

E

E

A

R

R

G

G

M

M

L

L

I

I

L

L

D
|
D

E

E

A

A

Q
|
Q

T

T

G

G

I

V

G

G

R

R

T

T

G

G

T

T

M

M

F

F

A

A

F

C

Q

Q

R

R

D

D

G

G

V

V

T

T

P

P

D

D

I

I

L

L

T

T

L

L

S

S

K
|
K

T

T

I

L

G

G

A

A

G

G

L

L

P

P

L

L

S

A

A

A

V

I

M

V

T

T

T

S

T

A

E

A

I

I

E

E

A

R

A

A

H

H

E

E

K

L

G

G

F

Y

L

L

F

F

Y

Y

T

T

T
|
T

H

H

V

V

S

S

D

D

P

P

L

L

P

P

A

A

V

V

G

G

L

L

A

R

V

V

L

L

D

D

V

V

A

Q

E

R

E

D

G

G

L

L

V

V

E

A

R

R

A

A

R

N

H

V

I

M

G

G

G

D

E

R

L

L

F

R

D

R

G

G

L

L

S

L

Q

D

L

L

K

M

Q

E

R

R

F

F

D

D

C

C

V

I

G

G

D

D

V

V

R

R

G

G

R

R

G

G

L

L

M

L

L

L

G

G

V

V

E

E

I

I

V

V

K

K

P

D

G

R

E

R

S

T

R

K

S

E

A

P

D

A

H

D

E

G

L

L

G

G

S

A

R

K

I

I

A

T

A

R

E

E

A

C

F

M

R

N

R

L

G

G

L

L

S

S

M

M

N

N

I

I

V

V

K

Q

L

L

P

P

G

G

M

M

G

G

V

V

F

F

R
|
R

I

I

A

A

P

P

L

L

T

T

I

V

S

S

E

E

E

D

E

E

I

I

E

D

L

L

G

G

L

L

R

S

I

L

T

G

Q

Q

S

A

I

I

E

E

A

R

S

A

L

L

active site: G19 (= G21), W136 (= W137), E208 (= E210), D241 (= D243), Q244 (= Q246), K270 (= K272), T301 (= T303), R404 (= R406)
binding (1r)-1-[((1e)-{3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylene)amino]-1-methylpropylphosphonic acid: Q50 (= Q52), G109 (= G110), A110 (= A111), W136 (= W137), H137 (= H138), E208 (= E210), D241 (= D243), Q244 (= Q246), K270 (= K272), R404 (= R406)

1m0nA Structure of dialkylglycine decarboxylase complexed with 1- amin