SitesBLAST

P12425 Glutamine synthetase; GS; Glutamate--ammonia ligase; Glutamine synthetase I alpha; GSI alpha; EC 6.3.1.2 from Bacillus subtilis (strain 168) (see 5 papers)
31% identity, 99% coverage: 3:433/435 of query aligns to 7:441/444 of P12425

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G59 (≠ L55) mutation to R: Unable to form stable complex with TnrA. In the presence of glutamine, this mutant derepresses amtB-lacZ fusion and glnRA-lacZ fusion.
R62 (≠ T58) Important for inhibition by glutamine; mutation to A: Highly resistant to inhibition by glutamine and AMP. Regulation by TnrA and GlnR is abolished. Only small differences (less than 2-fold) in its steady-state kinetic constants compared with the wild-type. Similar sensitivity to Met-Sox that compared to the wild-ytpe.
E132 (= E123) binding Mg(2+)
E134 (= E125) binding Mg(2+)
E189 (= E180) binding Mg(2+)
V190 (≠ D181) mutation to A: Unable to form stable complex with TnrA. In the presence of glutamine, this mutant partially relieves expression of the glnRA-lacZ fusion, but has no effect on the TnrA-dependent regulation of amtB-lacZ fusion. Resistant to inhibition by MetSox.
E196 (= E187) binding Mg(2+)
G241 (= G232) binding L-glutamate
H245 (= H236) binding Mg(2+)
G302 (= G300) mutation to E: Unable to form stable complex with TnrA. In the presence of glutamine, amtB-lacZ fusion is only 4-fold regulated by TnrA, whereas glnRA-lacZ fusion is derepressed. This mutant retains enzymatic specific activity with a 2-fold decrease of the affinity for glutamate and glutamine compared to the wild-type. Slightly less sensitive to inhibition by glutamine.
E304 (≠ T302) mutation to A: Highly resistant to Met-Sox inhibition. 8- and 2-fold increase of the affinity for glutamate and ATP, respectively. Strong decrease of the affinity for ammonium.
P306 (= P305) mutation to H: Unable to form stable complex with TnrA. In the presence of glutamine, this mutant completely derepresses glnRA-lacZ fusion, whereas amtB-lacZ fusion expression is only partially derepresses.
E333 (= E328) binding Mg(2+)
E424 (= E416) mutation to K: Unable to form stable complex with TnrA. In the presence of glutamine, this mutant derepresses amtB-lacZ fusion and glnRA-lacZ fusion. Although it is defective in regulation, this mutant retains enzymatic specific activity and similar affinity for ATP, glutamate and glutamine compared to the wild-type. Slightly less sensitive to inhibition by glutamine.

Sites not aligning to the query:

1 modified: Initiator methionine, Removed

4lnkA B. Subtilis glutamine synthetase structures reveal large active site conformational changes and basis for isoenzyme specific regulation: structure of gs-glutamate-amppcp complex (see paper)
31% identity, 99% coverage: 3:433/435 of query aligns to 6:440/443 of 4lnkA

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active site: D52 (≠ A49), E131 (= E123), E133 (= E125), E188 (= E180), E195 (= E187), H244 (= H236), R315 (= R315), E332 (= E328), R334 (= R330)
binding adenosine-5'-diphosphate: K43 (≠ N40), M50 (≠ G47), F198 (≠ W190), Y200 (= Y192), N246 (≠ H238), S248 (= S240), S324 (vs. gap), S328 (≠ P324), R330 (= R326)
binding glutamic acid: E133 (= E125), E188 (= E180), V189 (≠ D181), N239 (≠ T231), G240 (= G232), G242 (= G234), E303 (≠ T302)
binding magnesium ion: E131 (= E123), E188 (= E180), E195 (= E187), H244 (= H236), E332 (= E328)

4lniA B. Subtilis glutamine synthetase structures reveal large active site conformational changes and basis for isoenzyme specific regulation: structure of the transition state complex (see paper)
31% identity, 99% coverage: 3:433/435 of query aligns to 6:440/443 of 4lniA

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L

G

Q

L

L

S

S

A

E

K

T

G

A

K

K

T

H

F

F

L

I

G

A

G

G

I

I

M

V

K

K

H

H

A

A

S

T

A

S

L

F

A

T

A

A

I

V

T

T

N

N

P

P

T

T

V

V

N

N

S

S

Y

Y

K

K

R
|
R

I

L

N

-

A

-

P

-

R

-

T

-

I

V

S

P

G

G

A

Y

T
x
E

W

-

A

A

P

P

N

C

T

Y

V

V

T

A

W

W

T

S

G

A

N

Q

N

N

R
|
R

T

S

H

P

M

L

V

I

R
|
R

V

I

P

P

G

A

-

S

-

R

-

G

-

I

P

S

G

T

R
|
R

F

V

E
|
E

L

V

R
|
R

L

S

P

V

D

D

G

P

A

A

V

A

N

N

P

P

Y

Y

L

L

L

A

Q

L

A

S

I

V

I

L

A

A

G

G

L

L

S

D

G

G

L

I

K

K

S

N

D

K

A

L

D

E

P

A

G

P

P

A

H

P

Y

I

D

D

I

R

D

N

M

I

Y

Y

-

V

-

M

-

S

R

K

D

E

G

E

H

R

L

M

V

E

N

N

D

G

A

I

P

V

K

D

L

L

P

P

L

A

N

T

L

L

L

A

D

E

A

A

L

L

R

E

A

E

Y

F

E

K

E

S

D

N

E

E

G

V

L

M

Q

V

A

K

A

A

L

L

G

G

M

E

E

H

F

L

S

F

A

E

A

H

Y

F

L

I

K

E

L

A

K

K

H

E

A

I

E

E

W

W

N

D

T

M

H

F

C

R

S

T

Q

Q

F

V

S

H

A

P

W

W

E

E

H

R

Q

E

T

Q

T

Y

L

M

active site: D52 (≠ A49), E131 (= E123), E133 (= E125), E188 (= E180), E195 (= E187), H244 (= H236), R315 (= R315), E332 (= E328), R334 (= R330)
binding adenosine-5'-diphosphate: E131 (= E123), E183 (≠ Y175), D197 (≠ N189), Y200 (= Y192), N246 (≠ H238), S248 (= S240), R320 (= R320), R330 (= R326)
binding magnesium ion: E131 (= E123), E131 (= E123), E133 (= E125), E188 (= E180), E195 (= E187), E195 (= E187), H244 (= H236), E332 (= E328)
binding l-methionine-s-sulfoximine phosphate: E133 (= E125), E188 (= E180), H244 (= H236), R297 (= R291), E303 (≠ T302), R315 (= R315), R334 (= R330)

8tfkA Glutamine synthetase (see paper)
33% identity, 98% coverage: 3:428/435 of query aligns to 4:432/440 of 8tfkA

query
sites
8tfkA

Q

E

D

D

L

V

A

L

T

E

I

A

A

V

A

K

E

E

R

R

G

D

I

V

K

K

Y

F

F

I

M

R

I

T

S

Q

Y

F

T

T

D

D

L

T

F

L

G

G

A

I

Q

I

R

K

A

S

K

W

L

A

V

I

P

P

T

A

E

E

A

Q

I

L

A

E

N

E

M

A

Q

F

K

E

D

N

G

G

A

V

G

M

F

F

A

D

G

G

F

S

A

S

T

I

W

Q

L

G

D

F

L

T

T

R

P

I

A

E

H

E

P

S

D

D

L

M

F

K

A

L

V

A

P

L

D

D

A

P

S

S

S

T

V

F

I

R

Q

I

L

L

P

P

W

W

K

R

K

P

D

A

-

T

-

G

-

A

V

V

A

A

W

R

V

I

A

L

A

G

D

D

C

V

V

Y

M

L

E

P

D

D

-

G

K

N

P

P

V

F

G

K

Q

G

A

D

P

P

R

R

V

Y

V

V

L

L

K

K

K

T

L

A

V

I

A

K

E

E

A

A

A

E

E

K

H

M

G

G

L

F

R

S

V

M

K

N

T

V

G

G

V

P

E
|
E

P

L

E
|
E

F

F

L

L

I

F

S

K

A

L

D

D

G

A

E

N

K

G

I

N

S

P

D

T

E

T

F

E

D

L

T

T

A

D

E

Q

K

G

P

G

C

Y

Y

F

D

D

Q

F

Q

A

A

P

L

L

M

D

R

R

R

A

Y

Q

D

D

V

V

I

R

A

R

E

D

I

I

C

-

D

D

Y

Y

M

A

L

L

E

E

-

H

L

M

G

G

W

F

K

Q

P

I

Y

E

Q

A

N

S

D

H

H

H

E
|
E

D

V

A

A

N

P

G

S

Q

Q

F

H

E
|
E

M

I

N
x
D

W
x
F

E

R

Y
x
F

D

G

D

D

A

V

L

L

K

C

T

T

A

A

D

D

K

N

H

V

S

V

F

T

F

F

K

K

F

Y

M

V

V

V

K

K

S

S

V

I

A

A

E

Y

K

H

H

K

G

G

L

Y

R

Y

A

A

T

S

F

F

M

M

P

P

K

K

P

P

F

L

K

F

G

G

L

V

T

N

G
|
G

N

S

G

G

C

M

H
|
H

A

S

H
x
N

I

Q

S

S

V

L

W

F

D

-

T

K

D

D

G

G

K

K

I

-

N

N

A

V

F

F

A

Y

D

D

K

P

A

D

M

T

P

P

F

T

G

K

L

L

S

S

A

Q

K

D

G

A

K

M

T

Y

F

Y

L

I

G

G

I

L

M

L

K

K

H

H

A

I

S

R

A

E

L

F

A

T

A

A

I

V

T

T

N

N

P

P

T

V

V

V

N

N

S

S

Y

Y

K

K

R
|
R

I

L

N

-

A

-

P

-

R

-

T

-

I

V

S

P

G

G

A

Y

T
x
E

W

-

A

A

P

P

N

V

T

Y

V

I

T

S

W

W

T

S

G

A

N

Q

N

N

R
|
R

T

S

H

S

M

L

V

I

R
|
R

V

I

P

P

-

A

-

T

-

R

G

G

P

N

G
|
G

-

T

R
|
R

F

I

E
|
E

L

L

R
|
R

L

C

P

P

D

D

G

P

A

A

V

C

N

N

P

P

Y

Y

L

L

L

A

Q

F

A

A

I

L

I

M

I

L

A

R

A

A

G

G

L

L

S

E

G

G

L

I

K

K

S

N

D

K

A

I

D

D

P

P

G

G

P

E

H

P

Y

T

D

N

I

V

D

N

M

I

Y

F

R

-

D

-

G

-

H

H

L

L

V

S

N

D

D

K

A

E

P

R

K

E

-

E

-

R

-

G

-

I

-

R

-

S

L

L

P

P

L

A

N

D

L

L

L

K

D

E

A

A

L

I

R

D

A

E

Y

M

E

K

E

G

D

S

E

K

G

F

L

V

Q

K

A

E

A

A

L

L

G

G

M

E

E

H

F

V

S

F

A

S

A

H

Y

Y

L

L

K

C

L

A

K

K

H

E

A

M

E

E

W

W

N

D

T

E

H

Y

C

K

S

A

Q

V

F

V

S

H

A

P

W

W

E

E

binding adenosine-5'-diphosphate: E128 (= E123), D194 (≠ N189), F195 (≠ W190), F197 (≠ Y192), N243 (≠ H238), R312 (= R315), R317 (= R320), G325 (= G325), R327 (= R326)
binding magnesium ion: E128 (= E123), E128 (= E123), E130 (= E125), E185 (= E180), E192 (= E187), E192 (= E187), H241 (= H236), E329 (= E328)
binding l-methionine-s-sulfoximine phosphate: E128 (= E123), E130 (= E125), E185 (= E180), E192 (= E187), G237 (= G232), H241 (= H236), R294 (= R291), E300 (≠ T302), R312 (= R315), R331 (= R330)

7tf6A Glutamine synthetase (see paper)
33% identity, 98% coverage: 3:429/435 of query aligns to 5:431/438 of 7tf6A

query
sites
7tf6A

Q

E

D

D

L

I

A

R

T

K

I

F

A

A

A

E

E

E

R

E

G

N

I

V

K

R

Y

Y

F

L

M

R

I

L

S

Q

Y

F

T

T

D

D

L

I

F

L

G

G

A

T

Q

I

R

K

A

N

K

V

L

E

V

V

P

P

T

V

E

S

A

Q

I

L

A

E

N

K

-

V

-

L

-

D

-

N

-

E

M

M

Q

M

K

F

D

D

G

G

A

S

G

S

F

I

A

E

G

G

F
|
F

A

V

T
x
R

W

I

L

-

D

-

L

-

T

-

P

-

A

E

H

E

P

S

D

D

L

M

F

Y

A

L

V

H

P

P

D

D

A

L

S

D

S

T

V

W

I

V

Q

I

L

F

P

P

W

W

K

G

K

K

D

-

V

V

A

A

W

R

V

L

A

I

A

C

D

D

C

V

V

Y

M

K

E

T

D

D

-

G

K

T

P

P

V

F

G

E

Q

G

A

D

P

P

R

R

V

A

V

N

L

L

K

K

K

R

L

V

V

L

A

K

E

E

A

M

A

E

E

D

H

L

G

G

L

F

R

T

-

D

V

F

K

N

T

L

G

G

V

P

E
|
E

P

P

E
|
E

F

F

L

L

I

F

S

K

A

L

D

D

-

E

-

K

G

G

E

E

-

P

-

T

-

L

K

E

I

L

S

N

D

D

E

D

-

G

-

Y

F

F

D

D

T

L

A

A

E

P

K

T

P

-

C

-

Y

-

D

D

Q

L

Q

G

A

E

L

N

M

C

R

R

Y

-

D

D

V

I

I

V

A

L

E

E

I

L

C

E

D

D

Y

-

M

-

L

-

E

-

L

M

G

G

W

F

K

D

P

I

Y

E

Q

A

N

S

D

H

H

H

E
|
E

D

V

A

A

N

P

G

G

Q

Q

F

H

E
|
E

M

I

N

D

W

F

E

K

Y

Y

D

A

D

D

A

A

L

V

K

T

T

A

A

C

D

D

K

N

H

I

S

Q

F

T

F

F

K

K

F

L

M

V

V

V

K

K

S

T

V

I

A

A

E

R

K

K

H

H

G

N

L

L

R

H

A

A

T

T

F

F

M

M

P

P

K

K

P

P

F

L

K

F

G
|
G

L

V

T
x
N

G
|
G

N

S

G

G

C

M

H
|
H

A

F

H

N

I

V

S

S

V

L

W

F

D

-

T

-

D

K

G

G

K

K

I

E

N

N

A

A

F

F

A

F

D

D

K

P

A

N

M

T

P

E

F

M

G

G

L

L

S

T

A

E

K

T

G

A

K

Y

T

Q

F

F

L

T

G

A

G

G

I

V

M

L

K

K

H

N

A

A

S

R

A

G

L

F

A

T

A

A

I

V

T

C

N

N

P

P

T

L

V

V

N

N

S

S

Y

Y

K

K

R
|
R

I

L

N

-

A

-

P

-

R

-

T

-

I

V

S

P

G
|
G

A
x
Y

T
x
E

W

-

A

A

P

P

N

C

T

Y

V

I

T

A

W

W

T

S

G

G

N

K

N

N

R
|
R

T

S

H

P

M

L

V

I

R

R

V

V

P

P

G

S

-

S

-

R

-

G

-

L

P

S

G

T

R

R

F

I

E
|
E

L

V

R

R

L

S

P

V

D

D

G

P

A

A

V

A

N

N

P

P

Y

Y

L

M

L

A

Q

L

A

A

I

A

I

I

I

L

A

E

A

A

G

G

L

L

S

D

G

G

L

I

K

K

S

N

D

K

-

L

-

K

-

V

A

P

D

E

P

P

G

V

P

N

H

Q

Y

N

D

I

I
x
Y

D

E

M

M

Y

N

R

R

D

E

G

E

H

R

L

E

V

A

N

V

D

G

A

I

P

Q

K

D

L

L

P

P

L

S

N

T

L

L

L

Y

D

T

A

A

L

L

R

K

A

A

Y

M

E

R

E

E

D

N

E

E

G

V

L

I

Q

K

A

K

A

A

L

L

G

G

M

N

E

H

F

I

S

Y

A

N

A

Q

Y

F

L

I

K

N

L

S

K

K

H

S

A

I

E

E

W

W

N

D

T
x
Y

H

Y

C

R

S

T

Q

Q

F

V

S

S

A

E

W

W

E

E

H

R

binding glutamine: E128 (= E125), E183 (= E180), G235 (= G232), H239 (= H236), R292 (= R291), E298 (≠ T302)
binding magnesium ion: E126 (= E123), E128 (= E125), E183 (= E180), E190 (= E187), H239 (= H236), E327 (= E328)
binding : F58 (= F51), R60 (≠ T53), G232 (= G229), N234 (≠ T231), G296 (= G300), Y297 (≠ A301), R310 (= R315), Y367 (≠ I365), Y421 (≠ T419)

Sites not aligning to the query:

binding : 433, 437

7tenA Glutamine synthetase (see paper)
32% identity, 100% coverage: 3:435/435 of query aligns to 5:441/442 of 7tenA

query
sites
7tenA

Q

E

D

D

L

I

A

F

T

R

I

F

A

A

A

D

E

E

R

Q

G

N

I

V

K

K

Y

F

F

I

M

R

I

L

S

Q

Y

F

T

T

D

D

L

I

F

L

G

G

A

I

Q

I

R

K

A

N

K

V

L

E

V

I

P

P

T

V

E

S

A

Q

I

L

A

K

N

K

M

A

Q

L

K

D

D

N

G

K

A

I

G

M

F

F

A

D

G

G

F

S

A

S

T

I

W

E

L

G

D

F

L

V

T

R

P

I

A

E

H

E

P

S

D

D

L

M

F

Y

A

L

V

F

P

P

D

D

A

L

S

D

S

T

V

W

I

V

Q

V

L

F

P

P

W

W

-

T

-

A

-

E

K

K

K

G

D

K

V

V

A

A

W

R

V

M

A

I

A

C

D

D

C

I

V

Y

M

N

E

P

D

D

-

M

K

T

P

P

V

F

G

A

Q

G

A

D

P

P

R

R

V

A

V

N

L

L

K

K

K

R

L

V

V

L

A

K

E

E

A

M

A

E

E

E

H

L

G

G

L

F

-

T

R

E

V

F

K

N

T

L

G
|
G

V

P

E
|
E

P

P

E
|
E

F

F

L

L

I

F

S

K

A

L

D

D

G

E

E

N

K

R

-

R

-

P

-

T

-

L

-

E

I

L

S

N

D

D

E

S

-

G

-

Y

F

F

D

D

T

L

A

A

E

P

K

T

P

D

C

L

Y

G

D

E

Q

N

Q

C

A

-

L

-

M

-

R

-

R

R

Y

R

D

D

V

I

I

V

A

L

E

E

I

-

C

-

D

-

Y

-

M

L

L

E

E

E

L

M

G

G

W

F

K

E

P

I

Y
x
E

Q

A

N

S

D

H

H

H

E
|
E

D

V

A

A

N

P

G

G

Q

Q

F

H

E
|
E

M

I

N
x
D

W
x
F

E
x
K

Y
|
Y

D

E

D

D

A

A

L

I

K

T

T

A

A

C

D

D

K

S

H

I

S

Q

F

T

F

F

K

K

F

L

M

V

V

V

K

K

S

T

V

I

A

A

E

R

K

K

H

H

G

G

L

L

R

H

A

A

T

T

F

F

M

M

P

P

K

K

P

P

F

L

K

F

G

G

L

V

T
x
N

G
|
G

N

S

G

G

C

M

H
|
H

A

F

H
x
N

I

M

S
|
S

V

L

W

F

D

N

T

E

D

K

G

G

K

-

I

-

N

N

A

A

F

F

A

F

D

D

K

E

A

S

M

G

P

E

F

L

G

E

L

L

S

S

A

Q

K

T

G

A

K

Y

T

H

F

F

L

L

G

A

G

G

I

M

M

L

K

K

H

H

A

A

S

R

A

G

L

Y

A

T

A

A

I

V

T

T

N

N

P

P

T

T

V

I

N

N

S

S

Y

F

K

K

R
|
R

I

L

N

-

A

-

P

-

R

-

T

-

I

V

S

P

G

G

A

Y

T
x
E

W

-

A

A

P

P

N

C

T

Y

V

I

T

A

W

W

T

S

G

G

N

K

N

N

R
|
R

T

S

H

P

M

L

V

V

R
|
R

V

V

P

P

G

S

-

S

-

R

-

G

-

L

P
x
S

G

T

R
|
R

F

L

E

E

L

L

R
|
R

L

S

P

V

D

D

G

P

A

S

V

A

N

N

P

P

Y

Y

L

L

L

A

Q

M

A

A

I

V

I

L

A

K

A

A

G

G

L

L

S

S

G

G

L

I

K

K

S

D

D

E

A

L

D

T

P

P

G

P

P

A

H

P

Y

V

D

D

I

R

D

N

M

I

Y

Y

-

G

-

M

-

N

-

E

R

R

D

E

G

A

H

T

L

G

V

I

N

Y

D

D

A

-

P

-

K

-

L

L

P

P

L

E

N

S

L

L

L

G

D

H

A

A

L

L

R

I

A

E

Y

L

E

E

E

K

D

N

E

E

G

I

L

I

Q

K

A

D

A

G

L

L

G

G

M

E

E

H

F

I

S

F

A

E

A

H

Y

F

L

I

K

E

L

A

K

K

H

T

A

I

E

E

W

C

N

D

T

M

H

F

C

R

S

T

Q

A

F

V

S

H

A

P

W

W

E

E

H

R

Q

E

T

Q

T

Y

L

L

D

E

V

I

binding adenosine-5'-diphosphate: G128 (= G121), E130 (= E123), E182 (≠ Y175), D196 (≠ N189), F197 (≠ W190), K198 (≠ E191), Y199 (= Y192), N245 (≠ H238), S247 (= S240), R319 (= R320), S327 (≠ P324), R329 (= R326)
binding l-methionine-s-sulfoximine phosphate: E130 (= E123), E132 (= E125), E187 (= E180), E194 (= E187), N238 (≠ T231), G239 (= G232), H243 (= H236), R296 (= R291), E302 (≠ T302), R314 (= R315), R333 (= R330)

7tf9S L. Monocytogenes gs(14)-q-glnr peptide (see paper)
32% identity, 100% coverage: 3:435/435 of query aligns to 6:442/443 of 7tf9S

query
sites
7tf9S

Q

E

D

D

L

I

A

F

T

R

I

F

A

A

A

D

E

E

R

Q

G

N

I

V

K

K

Y

F

F

I

M

R

I

L

S

Q

Y

F

T

T

D

D

L

I

F

L

G

G

A

I

Q

I

R

K

A

N

K

V

L

E

V

I

P

P

T

V

E

S

A

Q

I

L

A

K

N

K

M

A

Q

L

K

D

D

N

G

K

A

I

G

M

F

F

A

D

G

G

F

S

A

S

T

I

W

E

L

G

D
x
F

L
x
V

T

R

P

I

A

E

H

E

P

S

D

D

L

M

F

Y

A

L

V

F

P

P

D

D

A

L

S

D

S

T

V

W

I

V

Q

V

L

F

P

P

W

W

-

T

-

A

-

E

K

K

K

G

D

K

V

V

A

A

W

R

V

M

A

I

A

C

D

D

C

I

V

Y

M

N

E

P

D

D

-

M

K

T

P

P

V

F

G

A

Q

G

A

D

P

P

R

R

V

A

V

N

L

L

K

K

K

R

L

V

V

L

A

K

E

E

A

M

A

E

E

E

H

L

G

G

L

F

-

T

R

E

V

F

K

N

T

L

G

G

V

P

E
|
E

P

P

E
|
E

F

F

L

L

I

F

S

K

A

L

D

D

G

E

E

N

K

R

-

R

-

P

-

T

-

L

-

E

I

L

S

N

D

D

E

S

-

G

-
x
Y

F

F

D

D

T

L

A

A

E

P

K

T

P

D

C

L

Y

G

D

E

Q

N

Q

C

A

-

L

-

M

-

R

-

R

R

Y

R

D

D

V

I

I

V

A

L

E

E

I

-

C

-

D

-

Y

-

M

L

L

E

E

E

L

M

G

G

W

F

K

E

P

I

Y

E

Q

A

N

S

D

H

H

H

E
|
E

D

V

A

A

N

P

G

G

Q

Q

F

H

E
|
E

M

I

N

D

W

F

E

K

Y

Y

D

E

D

D

A

A

L

I

K

T

T

A

A

C

D

D

K

S

H

I

S

Q

F

T

F

F

K

K

F

L

M

V

V

V

K

K

S

T

V

I

A

A

E

R

K

K

H

H

G

G

L

L

R

H

A

A

T

T

F

F

M

M

P

P

K

K

P

P

F

L

K

F

G

G

L

V

T

N

G
|
G

N

S

G
|
G

C

M

H
|
H

A

F

H

N

I

M

S

S

V

L

W

F

D

N

T

E

D

K

G

G

K

-

I

-

N

N

A

A

F

F

A

F

D

D

K

E

A

S

M

G

P

E

F

L

G

E

L

L

S

S

A

Q

K

T

G

A

K

Y

T

H

F

F

L

L

G

A

G

G

I

M

M

L

K

K

H

H

A

A

S

R

A

G

L

Y

A

T

A

A

I

V

T

T

N

N

P

P

T

T

V

I

N

N

S

S

Y

F

K

K

R
|
R

I

L

N

-

A

-

P

-

R

-

T

-

I

V

S

P

G

G

A

Y

T
x
E

W

-

A

A

P

P

N

C

T

Y

V

I

T

A

W

W

T

S

G

G

N

K

N

N

R

R

T

S

H

P

M

L

V

V

R

R

V

V

P

P

G

S

-

S

-

R

-

G

-

L

P

S

G

T

R

R

F

L

E
|
E

L

L

R

R

L

S

P

V

D

D

G

P

A

S

V

A

N

N

P

P

Y

Y

L

L

L

A

Q

M

A

A

I

V

I

L

A

K

A

A

G

G

L

L

S

S

G

G

L

I

K

K

S

D

D

E

A

L

D

T

P

P

G

P

P

A

H

P

Y

V

D

D

I

R

D

N

M

I

Y

Y

-

G

-

M

-

N

-

E

R

R

D

E

G

A

H

T

L

G

V

I

N

Y

D

D

A

-

P

-

K

-

L

L

P

P

L

E

N

S

L

L

L

G

D

H

A

A

L

L

R

I

A

E

Y

L

E

E

E

K

D

N

E

E

G

I

L

I

Q

K

A

D

A

G

L

L

G

G

M

E

E

H

F

I

S

F

A

E

A

H

Y

F

L

I

K
x
E

L

A

K

K

H

T

A
x
I

E

E

W

C

N

D

T
x
M

H

F

C

R

S

T

Q

A

F

V

S

H

A

P

W

W

E

E

H

R

Q

E

T

Q

T

Y

L

L

D

E

V

I

binding glutamine: E133 (= E125), Y155 (vs. gap), E188 (= E180), G240 (= G232), G242 (= G234), R297 (= R291), E303 (≠ T302)
binding magnesium ion: E131 (= E123), E133 (= E125), E188 (= E180), E195 (= E187), H244 (= H236), E332 (= E328)
binding : F59 (≠ D56), V60 (≠ L57), E418 (≠ K411), I422 (≠ A415), M426 (≠ T419)

8ufjB Glutamine synthetase (see paper)
33% identity, 98% coverage: 3:428/435 of query aligns to 8:436/444 of 8ufjB

query
sites
8ufjB

Q

E

D

D

L

V

A

L

T

E

I

A

A

V

A

K

E

E

R

R

G

D

I

V

K

K

Y

F

F

I

M

R

I

T

S

Q

Y

F

T

T

D

D

L

T

F

L

G

G

A

I

Q

I

R

K

A

S

K

W

L

A

V

I

P

P

T

A

E

E

A

Q

I

L

A

E

N

E

M

A

Q

F

K

E

D

N

G

G

A

V

G

M

F

F

A

D

G

G

F

S

A

S

T

I

W

Q

L

G

D

F

L

T

T

R

P

I

A

E

H

E

P

S

D

D

L

M

F

K

A

L

V

A

P

L

D

D

A

P

S

S

S

T

V

F

I

R

Q

I

L

L

P

P

W

W

K

R

K

P

D

A

-

T

-

G

-

A

V

V

A

A

W

R

V

I

A

L

A

G

D

D

C

V

V

Y

M

L

E

P

D

D

-

G

K

N

P

P

V

F

G

K

Q

G

A

D

P

P

R

R

V

Y

V

V

L

L

K

K

K

T

L

A

V

I

A

K

E

E

A

A

A

E

E

K

H

M

G

G

L

F

R

S

V

M

K

N

T

V

G

G

V

P

E
|
E

P

L

E
|
E

F

F

L

L

I

F

S

K

A

L

D

D

G

A

E

N

K

G

I

N

S

P

D

T

E

T

F

E

D

L

T

T

A

D

E

Q

K

G

P

G

C

Y

Y

F

D

D

Q

F

Q

A

A

P

L

L

M

D

R

L

R

G

Y

Q

D

D

V

V

I

R

A

R

E

D

I

I

C

-

D

D

Y

Y

M

A

L

L

E

E

-

H

L

M

G

G

W

F

K

Q

P

I

Y

E

Q

A

N

S

D

H

H

H

E
|
E

D

V

A

A

N

P

G

S

Q

Q

F

H

E
|
E

M

I

N

D

W

F

E

R

Y

F

D

G

D

D

A

V

L

L

K

C

T

T

A

A

D

D

K

N

H

V

S

V

F

T

F

F

K

K

F

Y

M

V

V

V

K

K

S

S

V

I

A

A

E

Y

K

H

H

K

G

G

L

Y

R

Y

A

A

T

S

F

F

M

M

P

P

K

K

P

P

F

L

K

F

G

G

L

V

T

N

G

G

N

S

G

G

C

M

H
|
H

A

S

H

N

I

Q

S

S

V

L

W

F

D

-

T

K

D

D

G

G

K

K

I

-

N

N

A

V

F

F

A

Y

D

D

K

P

A

D

M

T

P

P

F

T

G

K

L

L

S

S

A

Q

K

D

G

A

K

M

T

Y

F

Y

L

I

G

G

I

L

M

L

K

K

H

H

A

I

S

R

A

E

L

F

A

T

A

A

I

V

T

T

N

N

P

P

T

V

V

V

N

N

S

S

Y

Y

K

K

R

R

I

L

N

-

A

-

P

-

R

-

T

-

I

V

S

P

G

G

A

Y

T

E

W

-

A

A

P

P

N

V

T

Y

V

I

T

S

W

W

T

S

G

A

N

Q

N

N

R

R

T

S

H

S

M

L

V

I

R

R

V

I

P

P

-

A

-

T

-

R

G

G

P

N

G

G

-

T

R

R

F

I

E
|
E

L

L

R

R

L

C

P

P

D

D

G

P

A

A

V

C

N

N

P

P

Y

Y

L

L

L

A

Q

F

A

A

I

L

I

M

I

L

A

R

A

A

G

G

L

L

S

E

G

G

L

I

K

K

S

N

D

K

A

I

D

D

P

P

G

G

P

E

H

P

Y

T

D

N

I

V

D

N

M

I

Y

F

R

-

D

-

G

-

H

H

L

L

V

S

N

D

D

K

A

E

P

R

K

E

-

E

-

R

-

G

-

I

-

R

-

S

L

L

P

P

L

A

N

D

L

L

L

K

D

E

A

A

L

I

R

D

A

E

Y

M

E

K

E

G

D

S

E

K

G

F

L

V

Q

K

A

E

A

A

L

L

G

G

M

E

E

H

F

V

S

F

A

S

A

H

Y

Y

L

L

K

C

L

A

K

K

H

E

A

M

E

E

W

W

N

D

T

E

H

Y

C

K

S

A

Q

V

F

V

S

H

A

P

W

W

E

E

binding magnesium ion: E132 (= E123), E134 (= E125), E189 (= E180), E196 (= E187), H245 (= H236), E333 (= E328)

7tdvC Glutamine synthetase (see paper)
32% identity, 98% coverage: 3:429/435 of query aligns to 6:436/443 of 7tdvC

query
sites
7tdvC

Q

E

D

D

L

I

A

R

T

K

I

F

A

V

A

E

E

E

R

E

G

N

I

V

K

R

Y

Y

F

L

M

R

I

L

S

Q

Y

F

T

T

D

D

L

I

F

L

G

G

A

T

Q

I

R

K

A

N

K

V

L

E

V

V

P

P

T

V

E

S

A

Q

I

L

A

E

N

K

-

V

-

L

-

D

-

N

-

E

M

M

Q

M

K

F

D

D

G

G

A

S

G

S

F

I

A

E

G

G

F

F

A

V

T

R

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T

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A

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Y

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D

N

E

E

G

V

L

I

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K

A

K

A

A

L

L

G

G

M

N

E

H

F

I

S

Y

A

N

A

Q

Y

F

L

I

K

N

L

S

K

K

H

S

A

I

E

E

W

W

N

D

T

Y

H

Y

C

R

S

T

Q

Q

F

V

S

S

A

E

W

W

E

E

H

R

binding adenosine-5'-diphosphate: G129 (= G121), E131 (= E123), E183 (≠ Y175), D197 (≠ N189), F198 (≠ W190), K199 (≠ E191), Y200 (= Y192), N246 (≠ H238), V247 (≠ I239), S248 (= S240), R320 (= R320), S328 (≠ P324), R330 (= R326)
binding magnesium ion: E131 (= E123), E131 (= E123), E133 (= E125), E188 (= E180), E195 (= E187), E195 (= E187), H244 (= H236), E332 (= E328)
binding l-methionine-s-sulfoximine phosphate: E131 (= E123), E133 (= E125), E188 (= E180), E195 (= E187), G240 (= G232), H244 (= H236), R297 (= R291), E303 (≠ T302), R315 (= R315)

Query Sequence

>WP_011970786.1 NCBI__GCF_000017145.1:WP_011970786.1
MTQDLATIAAERGIKYFMISYTDLFGAQRAKLVPTEAIANMQKDGAGFAGFATWLDLTPA
HPDLFAVPDASSVIQLPWKKDVAWVAADCVMEDKPVGQAPRVVLKKLVAEAAEHGLRVKT
GVEPEFFLISADGEKISDEFDTAEKPCYDQQALMRRYDVIAEICDYMLELGWKPYQNDHE
DANGQFEMNWEYDDALKTADKHSFFKFMVKSVAEKHGLRATFMPKPFKGLTGNGCHAHIS
VWDTDGKINAFADKAMPFGLSAKGKTFLGGIMKHASALAAITNPTVNSYKRINAPRTISG
ATWAPNTVTWTGNNRTHMVRVPGPGRFELRLPDGAVNPYLLQAIIIAAGLSGLKSDADPG
PHYDIDMYRDGHLVNDAPKLPLNLLDALRAYEEDEGLQAALGMEFSAAYLKLKHAEWNTH
CSQFSAWEHQTTLDV

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory