SitesBLAST – Find functional sites

 

SitesBLAST

Comparing WP_011973623.1 NCBI__GCF_000017185.1:WP_011973623.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 3 hits to proteins with known functional sites (download)

2gtvX Nmr structure of monomeric chorismate mutase from methanococcus jannaschii (see paper)
39% identity, 91% coverage: 6:94/98 of query aligns to 3:99/104 of 2gtvX

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2gtvX
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P0A9J8 Bifunctional chorismate mutase/prephenate dehydratase; Chorismate mutase-prephenate dehydratase; P-protein; EC 5.4.99.5; EC 4.2.1.51 from Escherichia coli (strain K12)
29% identity, 82% coverage: 11:90/98 of query aligns to 10:89/386 of P0A9J8

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1ecmB Atomic structure of the buried catalytic pocket of escherichia coli chorismate mutase
29% identity, 77% coverage: 11:85/98 of query aligns to 5:79/95 of 1ecmB

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Sites not aligning to the query:

Query Sequence

>WP_011973623.1 NCBI__GCF_000017185.1:WP_011973623.1
MTNPKDRLNIIRNRINEIDEQLIKLMAERTQFAGEIANLKSELNMPINDEEREHHIKETI
KSLCNKYDFDSNLSLEILTLLMEHSKELQKKACEKKNI

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory