Comparing WP_011988726.1 NCBI__GCF_000016505.1:WP_011988726.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
3ng0A Crystal structure of glutamine synthetase from synechocystis sp. Pcc 6803
33% identity, 44% coverage: 205:479/632 of query aligns to 186:436/465 of 3ng0A
Sites not aligning to the query:
A0R079 Glutamine synthetase; GS; Glutamate--ammonia ligase; Glutamine synthetase I beta; GSI beta; EC 6.3.1.2 from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis) (see paper)
27% identity, 71% coverage: 29:474/632 of query aligns to 18:443/478 of A0R079
Sites not aligning to the query:
2wgsA Crystal structure of mycobacterium tuberculosis glutamine synthetase in complex with a purine analogue inhibitor. (see paper)
31% identity, 39% coverage: 230:474/632 of query aligns to 207:428/463 of 2wgsA
Sites not aligning to the query:
2whiA Crystal structure of mycobacterium tuberculosis glutamine synthetase in complex with a purine analogue inhibitor and l-methionine-s- sulfoximine phosphate. (see paper)
32% identity, 39% coverage: 230:474/632 of query aligns to 212:441/476 of 2whiA
Sites not aligning to the query:
1htoA Crystallographic structure of a relaxed glutamine synthetase from mycobacterium tuberculosis (see paper)
32% identity, 39% coverage: 230:474/632 of query aligns to 213:442/477 of 1htoA
Sites not aligning to the query:
4acfA Crystal structure of mycobacterium tuberculosis glutamine synthetase in complex with imidazopyridine inhibitor ((4-(6-bromo-3- (butylamino)imidazo(1,2-a)pyridin-2-yl)phenoxy) acetic acid) and l- methionine-s-sulfoximine phosphate.
32% identity, 39% coverage: 230:474/632 of query aligns to 211:440/475 of 4acfA
Sites not aligning to the query:
3zxvA Crystal structure of mycobacterium tuberculosis glutamine synthetase in complex with tri-substituted imidazole inhibitor (4-(2-tert-butyl- 4-(6-methoxynaphthalen-2-yl)-1h-imidazol-5-yl)pyridin-2-amine) and l- methionine-s-sulfoximine phosphate (see paper)
32% identity, 39% coverage: 230:474/632 of query aligns to 211:440/475 of 3zxvA
Sites not aligning to the query:
3zxrA Crystal structure of mycobacterium tuberculosis glutamine synthetase in complex with tri-substituted imidazole inhibitor (3-(2-tert-butyl- 5-(pyridin-4-yl)-1h-imidazol-4-yl)quinoline) and l-methionine-s- sulfoximine phosphate. (see paper)
32% identity, 39% coverage: 230:474/632 of query aligns to 211:440/475 of 3zxrA
Sites not aligning to the query:
2bvcA Crystal structure of mycobacterium tuberculosis glutamine synthetase in complex with a transition state mimic (see paper)
32% identity, 39% coverage: 230:474/632 of query aligns to 211:440/475 of 2bvcA
Sites not aligning to the query:
4xycA Nanomolar inhibitors of mycobacterium tuberculosis glutamine synthetase 1: synthesis, biological evaluation and x-ray crystallographic studies (see paper)
32% identity, 39% coverage: 230:474/632 of query aligns to 202:431/466 of 4xycA
Sites not aligning to the query:
P9WN39 Glutamine synthetase; GS; Glutamate--ammonia ligase; Glutamine synthetase I beta; GSI beta; EC 6.3.1.2 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 5 papers)
32% identity, 39% coverage: 230:474/632 of query aligns to 214:443/478 of P9WN39
Sites not aligning to the query:
P0A1P6 Glutamine synthetase; GS; Glutamate--ammonia ligase; Glutamine synthetase I beta; GSI beta; EC 6.3.1.2 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 4 papers)
32% identity, 40% coverage: 222:476/632 of query aligns to 200:437/469 of P0A1P6
Sites not aligning to the query:
1fpyA Crystal structure of glutamine synthetase from salmonella typhimurium with inhibitor phosphinothricin (see paper)
32% identity, 40% coverage: 222:476/632 of query aligns to 199:436/468 of 1fpyA
Sites not aligning to the query:
1f1hA Crystal structure of glutamine synthetase from salmonella typhimurium with thallium ions (see paper)
32% identity, 40% coverage: 222:476/632 of query aligns to 199:436/468 of 1f1hA
Sites not aligning to the query:
P77961 Glutamine synthetase; GS; Glutamate--ammonia ligase; Glutamine synthetase I beta; GSI beta; EC 6.3.1.2 from Synechocystis sp. (strain PCC 6803 / Kazusa)
34% identity, 36% coverage: 255:479/632 of query aligns to 221:444/473 of P77961
Sites not aligning to the query:
P0A9C5 Glutamine synthetase; GS; Glutamate--ammonia ligase; Glutamine synthetase I beta; GSI beta; EC 6.3.1.2 from Escherichia coli (strain K12) (see 3 papers)
31% identity, 40% coverage: 222:476/632 of query aligns to 200:437/469 of P0A9C5
Sites not aligning to the query:
8oozA Glutamine synthetase (see paper)
31% identity, 44% coverage: 221:497/632 of query aligns to 161:382/430 of 8oozA
Sites not aligning to the query:
8ooxB Glutamine synthetase (see paper)
31% identity, 44% coverage: 221:497/632 of query aligns to 169:390/438 of 8ooxB
Sites not aligning to the query:
8ooqB Glutamine synthetase from Methanothermococcus thermolithotrophicus (see paper)
34% identity, 28% coverage: 255:433/632 of query aligns to 197:361/446 of 8ooqB
Sites not aligning to the query:
8oooA Glutamine synthetase from methanothermococcus thermolithotrophicus in complex with 2-oxoglutarate and mgatp at 2.15 a resolution (see paper)
34% identity, 28% coverage: 255:433/632 of query aligns to 198:362/447 of 8oooA
Sites not aligning to the query:
>WP_011988726.1 NCBI__GCF_000016505.1:WP_011988726.1
MLKDLIYVIPKTMQSEDSLKELLTSHPEIKFVSLVGIDLSGNDTDEKIPIKIFLKDISGF
LKGSIQTDGSSVVLPGIATLNNAKVDMVCDCDVNWYIDYNTNNIDPETDKPVGTLRIPCF
FYHEHKAVDSRYVLKNCIQHFKTNLLNLFKEYPNSLSSFGLKYEDIDDVVATCATELEFW
VNTPNNPAEIEELSTSQTLQEQYWTRTKGAVRTALEQTLSTMELYGLEPEMGHKEVGGIK
SNIDDKGRFNHIMEQLEIDWKYSTAVQSVDNELLVKSIVKETFRNNGLEVTFLAKPIDGV
AGSGEHTHIGMALKLKSGKMINLFSSTKNHFLSIFGYASVMGILKNYEVINPFVSSTTDS
LRRLKPGFEAPVCIVTSIGHTVEIPSRNRTVLIGVVRDLENPLGTRFELRAPNPRTNTYL
AVTGLYMAMLDGITYAITGSKTEDDLLAELSKKPGEDASYLEKDRAYRSEEDVFEDFTDE
ERAKFFGTAPATVYENLTAIDKYPEKKAVLTKDDVLNDKLINSFKLGAIKRWLVELNHRI
LNEYIDEIRGYKLLHSVDKALDLDVATWMKIDALKCYLMKDSYSNKSLFSKIRIASEEKN
YEEVSNLQIEVEEKMSELRELYSIYKKNLLDI
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory