Comparing WP_011995754.1 NCBI__GCF_000017645.1:WP_011995754.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
2q3dA 2.2 a resolution crystal structure of o-acetylserine sulfhydrylase (oass) from mycobacterium tuberculosis in complex with the reaction intermediate alpha-aminoacrylate (see paper)
64% identity, 93% coverage: 21:325/328 of query aligns to 3:305/306 of 2q3dA
P9WP55 O-acetylserine sulfhydrylase; OAS sulfhydrylase; OASS; Cysteine synthase A; CSase A; O-acetylserine (thiol)-lyase A; OAS-TL A; O-acetylserine-specific cysteine synthase; Sulfide-dependent cysteine synthase; EC 2.5.1.47 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
64% identity, 93% coverage: 21:325/328 of query aligns to 3:305/310 of P9WP55
3zeiA Structure of the mycobacterium tuberculosis o-acetylserine sulfhydrylase (oass) cysk1 in complex with a small molecule inhibitor (see paper)
64% identity, 91% coverage: 21:320/328 of query aligns to 3:300/300 of 3zeiA
2q3cA 2.1 a resolution crystal structure of o-acetylserine sulfhydrylase (oass) holoenzyme from mycobacterium tuberculosis in complex with the inhibitory peptide dfsi (see paper)
64% identity, 91% coverage: 21:320/328 of query aligns to 3:300/300 of 2q3cA
4lmaA Crystal structure analysis of o-acetylserine sulfhydrylase cysk1 from microcystis aeruginosa 7806 (see paper)
59% identity, 94% coverage: 20:328/328 of query aligns to 2:311/318 of 4lmaA
4lmbA Crystal structure analysis of o-acetylserine sulfhydrylase cysk2 complexed with cystine from microcystis aeruginosa 7806 (see paper)
61% identity, 92% coverage: 25:326/328 of query aligns to 7:309/310 of 4lmbA
5xoqA Crystal structure of o-acetylserine sulfhydrylase with bound transcription factor peptide inhibitor from planctomyces limnophilus
59% identity, 94% coverage: 21:328/328 of query aligns to 4:309/310 of 5xoqA
P47998 Cysteine synthase 1; At.OAS.5-8; Beta-substituted Ala synthase 1;1; ARAth-Bsas1;1; CSase A; AtCS-A; Cys-3A; O-acetylserine (thiol)-lyase 1; OAS-TL A; O-acetylserine sulfhydrylase; Protein ONSET OF LEAF DEATH 3; EC 2.5.1.47 from Arabidopsis thaliana (Mouse-ear cress) (see 3 papers)
57% identity, 94% coverage: 20:326/328 of query aligns to 4:309/322 of P47998
2isqA Crystal structure of o-acetylserine sulfhydrylase from arabidopsis thaliana in complex with c-terminal peptide from arabidopsis serine acetyltransferase (see paper)
57% identity, 94% coverage: 20:326/328 of query aligns to 2:307/320 of 2isqA
4aecA Crystal structure of the arabidopsis thaliana o-acetyl-serine-(thiol)- lyasE C (see paper)
56% identity, 94% coverage: 20:328/328 of query aligns to 12:319/323 of 4aecA
8b9wA Cysteine synthase from trypanosoma theileri with plp bound (see paper)
54% identity, 92% coverage: 24:325/328 of query aligns to 12:311/329 of 8b9wA
1z7yA Crystal structure of the arabidopsis thaliana o-acetylserine sulfhydrylase k46a mutant (see paper)
56% identity, 94% coverage: 20:326/328 of query aligns to 2:307/320 of 1z7yA
7n2tA O-acetylserine sulfhydrylase from citrullus vulgaris in the internal aldimine state, with citrate bound (see paper)
57% identity, 93% coverage: 25:328/328 of query aligns to 7:309/309 of 7n2tA
P0A1E3 Cysteine synthase A; CSase A; O-acetylserine (thiol)-lyase A; OAS-TL A; O-acetylserine sulfhydrylase A; EC 2.5.1.47 from Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (see 4 papers)
56% identity, 94% coverage: 20:328/328 of query aligns to 3:315/323 of P0A1E3
Sites not aligning to the query:
6z4nAAA structure of oass complexed with upar inhibitor (see paper)
56% identity, 94% coverage: 20:328/328 of query aligns to 4:316/321 of 6z4nAAA
P0ABK5 Cysteine synthase A; CSase A; O-acetylserine (thiol)-lyase A; OAS-TL A; O-acetylserine sulfhydrylase A; S-carboxymethylcysteine synthase; Sulfate starvation-induced protein 5; SSI5; EC 2.5.1.47; EC 4.5.1.5 from Escherichia coli (strain K12) (see 5 papers)
56% identity, 94% coverage: 20:328/328 of query aligns to 3:315/323 of P0ABK5
Sites not aligning to the query:
P47999 Cysteine synthase, chloroplastic/chromoplastic; At.OAS.7-4; Beta-substituted Ala synthase 2;1; ARAth-Bsas2;1; CSase B; AtCS-B; CS-B; O-acetylserine (thiol)-lyase; O-acetylserine sulfhydrylase; OAS-TL B; cpACS1; EC 2.5.1.47 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
55% identity, 94% coverage: 21:328/328 of query aligns to 75:381/392 of P47999
Sites not aligning to the query:
1d6sA Crystal structure of the k41a mutant of o-acetylserine sulfhydrylase complexed in external aldimine linkage with methionine (see paper)
56% identity, 94% coverage: 20:328/328 of query aligns to 2:314/322 of 1d6sA
3t4pA Crystal structure of o-acetyl serine sulfhydrylase from leishmania donovani in complex with designed tetrapeptide (see paper)
52% identity, 96% coverage: 12:325/328 of query aligns to 1:312/319 of 3t4pA
8b9yC Cysteine synthase from trypanosoma cruzi with plp and oas (see paper)
52% identity, 95% coverage: 18:328/328 of query aligns to 7:315/330 of 8b9yC
>WP_011995754.1 NCBI__GCF_000017645.1:WP_011995754.1
MAGPAAKIVPAAQPRPGRGRVYDSITETIGNTPLVRLKRLAELRGAKAEILAKLEFFNPI
SSVKDRIGVAMIEAMEAAGVLDQDTVLVEPTSGNTGIALAFVAAARGYRLILVMPESMSV
ERRKMLAILGAELVLTPANLGMKGAVARAEQLIAELPKAAMPQQFKNKANPDIHRRTTAE
EIWNDTDGKVDAVVAGVGTGGTITGIGQVLKPRKASLKMIAVEPEDSPVLSGGSPGPHKI
QGIGAGFVPDVLDRSIIDEVVTVGNQTAFDTARALARYEGIPGGISSGAAVAAALEIAVR
DDMAGKSIVVIVPSFAERYLSTALFEGL
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory