SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing WP_012044726.1 NCBI__GCF_000015165.1:WP_012044726.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 1 hits to proteins with known functional sites (download)

3al0C Crystal structure of the glutamine transamidosome from thermotoga maritima in the glutamylation state. (see paper)
33% identity, 91% coverage: 8:93/95 of query aligns to 7:92/564 of 3al0C

query
sites
3al0C

V

V

R

L

R

H

I

L

A

E

Q

N

L

L

A

A

R

R

I

L

A

E

V

L

T

S

D

E

A

D

E

Q

V

R

P

E

H

S

L

L

Q

M

G

K

E

D

L

F

N

Q

A

E

M

I

L

L

N

D

F

Y

V

V

E

E

Q

L

L

L

S

N

E

E

V

V

N

D

V

V

E

E

G

G

V

V

E

E

P

P

M

M

T

Y

S

T

V

P

T

V

P

E

M

D

A

S

M

A

K

K

K

L

R

R

Q

K

D

G

V

D

V

P

N

R

D

F

G

F

E

E

I

M

A

R

D

D

D

L

I

I

V

K

K

K

N

N

A

F

P

P

A

E

T

E

E

K

N

D

H

G

F

H

F

I

L

K

V

V

P

P

K

G

V

I

Sites not aligning to the query:

active site: 110, 335
binding o5'-(l-glutamyl-sulfamoyl)-adenosine: 106, 108, 109, 118, 122, 142, 276, 294, 295, 297, 298, 324, 325, 333
binding : 144, 145, 148, 208, 213, 252, 255, 266, 269, 270, 276, 297, 298, 299, 300, 301, 304, 330, 332, 363, 364, 365, 370, 387, 389, 391, 392, 397, 400, 407, 446, 447, 453, 457, 509, 520, 524, 527, 535, 536, 538, 539

Query Sequence

>WP_012044726.1 NCBI__GCF_000015165.1:WP_012044726.1
MSVDAATVRRIAQLARIAVTDAEVPHLQGELNAMLNFVEQLSEVNVEGVEPMTSVTPMAM
KKRQDVVNDGEIADDIVKNAPATENHFFLVPKVVE

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory