SitesBLAST – Find functional sites

 

SitesBLAST

Comparing WP_012048834.1 NCBI__GCF_000016765.1:WP_012048834.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 2 hits to proteins with known functional sites (download)

4ymwC Crystal structure of an amino acid abc transporter with histidines (see paper)
34% identity, 56% coverage: 152:353/362 of query aligns to 17:212/214 of 4ymwC

query
sites
4ymwC
G
 
S
G
 
G
L
 
L
P
 
I
I
 
M
T
 
T
M
 
L
L
 
K
L
 
L
T
 
T
I
 
F
F
 
L
S
 
A
L
 
V
A
 
T
L
 
I
G
 
G
F
 
V
P
 
L
F
 
M
G
 
G
I
 
L
V
 
F
L
 
I
A
 
A
L
 
L
A
 
M
R
 
K
R
 
M
S
 
S
D
 
S
M
 
I
P
 
K
V
 
P
Y
 
I
R
 
K
W
 
L
T
 
V
A
 
A
T
 
S
A
 
S
L
 
Y
I
 
I
E
 
E
V
 
V
M
 
I
R
 
R
A
 
G
M
 
T
P
 
P
L
 
L
-
 
L
V
 
V
T
 
Q
L
 
L
L
 
L
F
 
L
V
 
I
A
 
Y
S
 
N
V
 
G
M
 
-
A
 
-
P
 
-
L
 
-
L
 
L
L
 
M
P
 
Q
A
 
F
G
 
G
V
 
M
T
 
N
A
 
I
D
 
P
N
 
A
L
 
F
T
 
T
R
 
A
A
 
G
L
 
V
V
 
S
A
 
A
F
 
L
V
 
A
L
 
I
S
x
N
S
 
S
S
 
S
A
 
A
Y
|
Y
I
 
V
A
 
A
E
 
E
V
 
I
V
 
I
R
 
R
G
 
A
G
 
G
L
 
I
Q
 
Q
G
 
A
V
 
V
P
 
D
P
 
P
G
 
G
Q
 
Q
R
 
N
E
 
E
S
 
A
A
 
A
R
 
R
A
 
S
L
 
L
G
 
G
L
 
M
G
 
T
R
 
H
S
 
A
T
 
M
V
 
A
L
 
M
L
 
R
S
 
Y
I
 
V
I
 
I
L
 
I
P
 
P
Q
 
Q
A
 
A
I
 
I
R
 
K
K
 
N
A
 
I
L
 
L
A
 
P
P
 
A
L
 
L
T
 
G
S
 
N
T
x
E
V
 
F
V
 
I
V
 
V
I
 
M
I
 
L
K
 
K
N
x
E
S
 
S
S
 
A
L
 
I
V
 
V
L
 
S
V
 
V
V
 
I
G
 
G
L
 
F
F
 
A
D
 
D
L
 
L
L
 
T
S
 
R
A
 
Q
G
 
A
R
 
D
V
 
I
S
 
I
L
 
-
N
 
-
D
 
-
P
 
Q
A
 
S
W
 
V
P
 
T
T
 
Y
P
 
R
Y
 
Y
A
 
F
E
 
E
T
 
P
Y
 
Y
L
 
I
V
 
I
I
 
I
A
 
A
L
 
A
I
 
I
Y
 
Y
F
 
F
V
 
V
I
 
M
C
 
T
Y
 
L
G
 
T
F
 
F
A
 
S
R
 
K
Y
 
L
A
 
L
L
 
S
H
 
L
L
 
F
E
 
E
R
 
R

4ymtC Crystal structure of an amino acid abc transporter complex with arginines (see paper)
34% identity, 56% coverage: 152:353/362 of query aligns to 17:212/215 of 4ymtC

query
sites
4ymtC
G
 
S
G
 
G
L
 
L
P
 
I
I
 
M
T
 
T
M
 
L
L
 
K
L
 
L
T
 
T
I
 
F
F
 
L
S
 
A
L
 
V
A
 
T
L
 
I
G
 
G
F
 
V
P
 
L
F
 
M
G
 
G
I
 
L
V
 
F
L
 
I
A
 
A
L
 
L
A
 
M
R
 
K
R
 
M
S
 
S
D
 
S
M
 
I
P
 
K
V
 
P
Y
 
I
R
 
K
W
 
L
T
 
V
A
 
A
T
 
S
A
 
S
L
 
Y
I
 
I
E
 
E
V
 
V
M
 
I
R
 
R
A
 
G
M
 
T
P
|
P
L
|
L
-
 
L
V
 
V
T
 
Q
L
 
L
L
 
L
F
 
L
V
 
I
A
 
Y
S
 
N
V
 
G
M
 
-
A
 
-
P
 
-
L
 
-
L
 
L
L
 
M
P
 
Q
A
 
F
G
 
G
V
 
M
T
 
N
A
 
I
D
 
P
N
 
A
L
 
F
T
 
T
R
 
A
A
 
G
L
 
V
V
 
S
A
 
A
F
 
L
V
 
A
L
 
I
S
x
N
S
 
S
S
 
S
A
 
A
Y
|
Y
I
 
V
A
 
A
E
 
E
V
 
I
V
 
I
R
 
R
G
 
A
G
 
G
L
 
I
Q
 
Q
G
 
A
V
 
V
P
 
D
P
 
P
G
 
G
Q
 
Q
R
 
N
E
 
E
S
 
A
A
 
A
R
 
R
A
 
S
L
 
L
G
 
G
L
 
M
G
 
T
R
 
H
S
 
A
T
 
M
V
 
A
L
 
M
L
 
R
S
 
Y
I
 
V
I
 
I
L
 
I
P
 
P
Q
 
Q
A
 
A
I
 
I
R
 
K
K
 
N
A
 
I
L
 
L
A
 
P
P
 
A
L
 
L
T
 
G
S
 
N
T
x
E
V
 
F
V
 
I
V
 
V
I
x
M
I
 
L
K
|
K
N
x
E
S
 
S
S
 
A
L
 
I
V
 
V
L
 
S
V
 
V
V
 
I
G
 
G
L
 
F
F
 
A
D
 
D
L
 
L
L
 
T
S
 
R
A
 
Q
G
 
A
R
 
D
V
 
I
S
 
I
L
 
-
N
 
-
D
 
-
P
 
Q
A
 
S
W
 
V
P
 
T
T
 
Y
P
 
R
Y
 
Y
A
 
F
E
 
E
T
 
P
Y
 
Y
L
 
I
V
 
I
I
 
I
A
 
A
L
 
A
I
 
I
Y
 
Y
F
 
F
V
 
V
I
 
M
C
 
T
Y
 
L
G
 
T
F
 
F
A
 
S
R
 
K
Y
 
L
A
 
L
L
 
S
H
 
L
L
 
F
E
 
E
R
 
R

Query Sequence

>WP_012048834.1 NCBI__GCF_000016765.1:WP_012048834.1
MRYVRTAPEPVRPAPPRPKRPALRSIVTGGANLLTTAIIVLFAIRTVPHLLSWAVTHGVW
SGDGAACREAGACWAFLRAKMPFILFGIYPEAERWRPILVVLILGAATLWSLPRAHWTRA
TLAFWGFAIVASLLLMAGGRLGLSPVPTSAWGGLPITMLLTIFSLALGFPFGIVLALARR
SDMPVYRWTATALIEVMRAMPLVTLLFVASVMAPLLLPAGVTADNLTRALVAFVLSSSAY
IAEVVRGGLQGVPPGQRESARALGLGRSTVLLSIILPQAIRKALAPLTSTVVVIIKNSSL
VLVVGLFDLLSAGRVSLNDPAWPTPYAETYLVIALIYFVICYGFARYALHLERTTQGGEG
RP

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory