Comparing WP_012049805.1 NCBI__GCF_000016765.1:WP_012049805.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 19 hits to proteins with known functional sites (download)
7t1qA Crystal structure of the succinyl-diaminopimelate desuccinylase (dape) from acinetobacter baumannii in complex with succinic acid
45% identity, 95% coverage: 15:374/377 of query aligns to 16:377/377 of 7t1qA
4o23A Crystal structure of mono-zinc form of succinyl diaminopimelate desuccinylase from neisseria meningitidis mc58 (see paper)
42% identity, 98% coverage: 5:373/377 of query aligns to 6:376/376 of 4o23A
4pqaA Crystal structure of succinyl-diaminopimelate desuccinylase from neisseria meningitidis mc58 in complex with the inhibitor captopril (see paper)
42% identity, 98% coverage: 5:372/377 of query aligns to 6:375/375 of 4pqaA
7lgpB Dape enzyme from shigella flexneri
41% identity, 98% coverage: 5:373/377 of query aligns to 8:377/377 of 7lgpB
5vo3A Crystal structure of dape in complex with the products (succinic acid and diaminopimelic acid) (see paper)
41% identity, 98% coverage: 5:372/377 of query aligns to 10:379/380 of 5vo3A
P44514 Succinyl-diaminopimelate desuccinylase; SDAP desuccinylase; N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase; EC 3.5.1.18 from Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) (see 3 papers)
41% identity, 98% coverage: 5:372/377 of query aligns to 6:375/377 of P44514
4h2kA Crystal structure of the catalytic domain of succinyl-diaminopimelate desuccinylase from haemophilus influenzae (see paper)
46% identity, 46% coverage: 5:178/377 of query aligns to 8:182/258 of 4h2kA
Sites not aligning to the query:
4op4B Crystal structure of the catalytic domain of dape protein from v.Cholerea in the zn bound form (see paper)
44% identity, 46% coverage: 5:178/377 of query aligns to 6:180/265 of 4op4B
Sites not aligning to the query:
7uoiA Crystallographic structure of dape from enterococcus faecium (see paper)
27% identity, 84% coverage: 59:373/377 of query aligns to 63:383/383 of 7uoiA
8uw6B Acetylornithine deacetylase from escherichia coli, di-zinc form. (see paper)
26% identity, 67% coverage: 5:256/377 of query aligns to 7:262/381 of 8uw6B
Sites not aligning to the query:
3pfoA Crystal structure of a putative acetylornithine deacetylase (rpa2325) from rhodopseudomonas palustris cga009 at 1.90 a resolution
27% identity, 57% coverage: 3:218/377 of query aligns to 20:238/426 of 3pfoA
Sites not aligning to the query:
Q96KN2 Beta-Ala-His dipeptidase; CNDP dipeptidase 1; Carnosine dipeptidase 1; Glutamate carboxypeptidase-like protein 2; Serum carnosinase; EC 3.4.13.20 from Homo sapiens (Human) (see 4 papers)
27% identity, 52% coverage: 25:219/377 of query aligns to 78:316/507 of Q96KN2
Sites not aligning to the query:
Q8C165 N-fatty-acyl-amino acid synthase/hydrolase PM20D1; Peptidase M20 domain-containing protein 1; PM20D1; EC 3.5.1.114; EC 3.5.1.14 from Mus musculus (Mouse) (see paper)
26% identity, 59% coverage: 54:276/377 of query aligns to 106:384/503 of Q8C165
Sites not aligning to the query:
3dljA Crystal structure of human carnosine dipeptidase 1
27% identity, 40% coverage: 68:219/377 of query aligns to 98:283/471 of 3dljA
Sites not aligning to the query:
2pokA Crystal structure of a m20 family metallo peptidase from streptococcus pneumoniae
41% identity, 19% coverage: 68:137/377 of query aligns to 88:163/458 of 2pokA
Sites not aligning to the query:
3ki9A Crystal structure of staphylococcus aureus metallopeptidase (sapep/dape) in the mn2+ bound form (see paper)
35% identity, 27% coverage: 60:161/377 of query aligns to 74:183/467 of 3ki9A
Sites not aligning to the query:
P45494 Beta-Ala-Xaa dipeptidase; Beta-Ala-His dipeptidase; Peptidase V; EC 3.4.13.- from Lactobacillus delbrueckii subsp. lactis (see paper)
51% identity, 12% coverage: 60:105/377 of query aligns to 76:122/470 of P45494
Sites not aligning to the query:
1lfwA Crystal structure of pepv (see paper)
51% identity, 12% coverage: 60:105/377 of query aligns to 76:122/468 of 1lfwA
Sites not aligning to the query:
Q8P8J5 N-acetyl-L-citrulline deacetylase; ACDase; Acetylcitrulline deacetylase; EC 3.5.1.- from Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25) (see paper)
33% identity, 39% coverage: 49:194/377 of query aligns to 53:183/366 of Q8P8J5
>WP_012049805.1 NCBI__GCF_000016765.1:WP_012049805.1
MIDPLDLTQRLIACPSVTPADAGAMAVIATALESIGFTVHRFAAGEAPDGPVENLFAIRG
QGGPHFAFAGHSDVVPPGDGWTSDPFVPEIRGELLHGRGAVDMKGAIAAFIAAAARLGDH
PGTISLIITGDEEGPATFGTVALIDWMKARGLCPDLCLVGEPTSTHRLGDMVKIGRRGSV
NMWIENVGTQGHVAYPHLAANPIPALVKALDALAALHLDDGNAWFQPSNLEITTVDVGNA
ATNVIPAVARARLNIRFNDEHRGADLVELVRRTVAEHAPAATVRAVISGESFITPPGDFS
ALISAAIMKVTGLTPELSTTGGTSDARFLSKLCPVVEFGLCNATMHKLDEAVAIPDLHAL
ADIYEDIVRTVLAHPGA
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory