Comparing WP_012050495.1 NCBI__GCF_000016765.1:WP_012050495.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
8uw6B Acetylornithine deacetylase from escherichia coli, di-zinc form. (see paper)
33% identity, 93% coverage: 4:362/388 of query aligns to 6:359/381 of 8uw6B
Sites not aligning to the query:
Q8P8J5 N-acetyl-L-citrulline deacetylase; ACDase; Acetylcitrulline deacetylase; EC 3.5.1.- from Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25) (see paper)
29% identity, 93% coverage: 8:369/388 of query aligns to 12:353/366 of Q8P8J5
7uoiA Crystallographic structure of dape from enterococcus faecium (see paper)
27% identity, 96% coverage: 5:378/388 of query aligns to 11:382/383 of 7uoiA
2f7vA Structure of acetylcitrulline deacetylase complexed with one co (see paper)
29% identity, 93% coverage: 8:369/388 of query aligns to 13:348/360 of 2f7vA
P44514 Succinyl-diaminopimelate desuccinylase; SDAP desuccinylase; N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase; EC 3.5.1.18 from Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) (see 3 papers)
26% identity, 85% coverage: 52:382/388 of query aligns to 50:375/377 of P44514
3pfoA Crystal structure of a putative acetylornithine deacetylase (rpa2325) from rhodopseudomonas palustris cga009 at 1.90 a resolution
33% identity, 54% coverage: 43:252/388 of query aligns to 77:288/426 of 3pfoA
Sites not aligning to the query:
5vo3A Crystal structure of dape in complex with the products (succinic acid and diaminopimelic acid) (see paper)
26% identity, 85% coverage: 52:382/388 of query aligns to 54:379/380 of 5vo3A
4pqaA Crystal structure of succinyl-diaminopimelate desuccinylase from neisseria meningitidis mc58 in complex with the inhibitor captopril (see paper)
31% identity, 54% coverage: 66:273/388 of query aligns to 64:274/375 of 4pqaA
Sites not aligning to the query:
4o23A Crystal structure of mono-zinc form of succinyl diaminopimelate desuccinylase from neisseria meningitidis mc58 (see paper)
31% identity, 54% coverage: 66:273/388 of query aligns to 64:274/376 of 4o23A
7t1qA Crystal structure of the succinyl-diaminopimelate desuccinylase (dape) from acinetobacter baumannii in complex with succinic acid
30% identity, 50% coverage: 66:258/388 of query aligns to 64:259/377 of 7t1qA
Sites not aligning to the query:
7lgpB Dape enzyme from shigella flexneri
25% identity, 82% coverage: 64:383/388 of query aligns to 63:377/377 of 7lgpB
Q03154 Aminoacylase-1; ACY-1; N-acyl-L-amino-acid amidohydrolase; EC 3.5.1.14 from Homo sapiens (Human) (see 6 papers)
26% identity, 54% coverage: 59:267/388 of query aligns to 70:286/408 of Q03154
Sites not aligning to the query:
4h2kA Crystal structure of the catalytic domain of succinyl-diaminopimelate desuccinylase from haemophilus influenzae (see paper)
35% identity, 34% coverage: 52:182/388 of query aligns to 52:191/258 of 4h2kA
Sites not aligning to the query:
P37111 Aminoacylase-1; ACY-1; N-acyl-L-amino-acid amidohydrolase; EC 3.5.1.14 from Sus scrofa (Pig) (see paper)
26% identity, 54% coverage: 59:267/388 of query aligns to 70:285/407 of P37111
Sites not aligning to the query:
3rzaA Crystal structure of a tripeptidase (sav1512) from staphylococcus aureus subsp. Aureus mu50 at 2.10 a resolution
25% identity, 78% coverage: 64:367/388 of query aligns to 72:356/373 of 3rzaA
Sites not aligning to the query:
4op4B Crystal structure of the catalytic domain of dape protein from v.Cholerea in the zn bound form (see paper)
35% identity, 27% coverage: 64:168/388 of query aligns to 62:170/265 of 4op4B
Sites not aligning to the query:
Q8C165 N-fatty-acyl-amino acid synthase/hydrolase PM20D1; Peptidase M20 domain-containing protein 1; PM20D1; EC 3.5.1.114; EC 3.5.1.14 from Mus musculus (Mouse) (see paper)
28% identity, 48% coverage: 8:192/388 of query aligns to 55:263/503 of Q8C165
Sites not aligning to the query:
2pokA Crystal structure of a m20 family metallo peptidase from streptococcus pneumoniae
36% identity, 28% coverage: 4:111/388 of query aligns to 23:134/458 of 2pokA
Sites not aligning to the query:
1q7lA Zn-binding domain of the t347g mutant of human aminoacylase-i (see paper)
37% identity, 20% coverage: 59:136/388 of query aligns to 64:144/192 of 1q7lA
Sites not aligning to the query:
7m6uB Crystal structure of a circular permutation and computationally designed pro-enzyme of carboxypeptidase g2 (see paper)
26% identity, 59% coverage: 58:286/388 of query aligns to 9:227/392 of 7m6uB
Sites not aligning to the query:
>WP_012050495.1 NCBI__GCF_000016765.1:WP_012050495.1
MGDWLPILRTLVGFPTVSADSNMELIEWVRDYLAGHGVEAHLTFDAAGRKANLFATVVPG
DGGLILSGHTDVVPVTGQQWSSDPFAAELRDGRVYGRGTCDMKGFIAVALALVPEMRALD
GARPLHLALSYDEELGCRGAPRMIDDLVRRGVRAGGCIVGEPTGMKAIIGHKGAGMYRCT
VTGRAAHSSLAPTGVNAIEYAACIVMKLREIGRRLEAIEPRHAGFDVPYSTIQVNRIDGG
TAGNIVADRCELRIDIRHLPATDRAALIAEVAAHVADELLPEMRLRAPEAAISIEEVADI
PPFEIAADASLVREVVRSNSVEGACGHVAFGSEAGLFQRAGIPTVICGPGSIEQAHRPDE
FVAIEQLERCDGMLRTMLGTVMAEVDIY
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory