SitesBLAST
Comparing WP_012050727.1 NCBI__GCF_000016765.1:WP_012050727.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
2j6hA E. Coli glucosamine-6-p synthase in complex with glucose-6p and 5-oxo- l-norleucine (see paper)
52% identity, 100% coverage: 2:608/608 of query aligns to 1:608/608 of 2j6hA
- active site: C1 (= C2), R26 (= R27), G27 (= G28), W74 (= W74), N98 (= N98), G99 (= G99), Y248 (≠ H249), E481 (= E480), K485 (= K484), E488 (= E487), H504 (= H503), K603 (= K603)
- binding glucose-6-phosphate: T302 (= T301), S347 (= S346), Q348 (= Q347), S349 (= S348), T352 (= T351), V399 (= V397), S401 (= S399), E488 (= E487)
- binding 5-oxo-l-norleucine: C1 (= C2), R73 (= R73), W74 (= W74), T76 (= T76), H86 (= H86), N98 (= N98), G99 (= G99), D123 (= D123)
4amvA E.Coli glucosamine-6p synthase in complex with fructose-6p (see paper)
52% identity, 100% coverage: 2:608/608 of query aligns to 1:608/608 of 4amvA
- active site: C1 (= C2), R26 (= R27), G27 (= G28), W74 (= W74), N98 (= N98), G99 (= G99), Y248 (≠ H249), E481 (= E480), K485 (= K484), E488 (= E487), H504 (= H503), K603 (= K603)
- binding fructose -6-phosphate: G301 (= G300), T302 (= T301), S303 (= S302), S347 (= S346), Q348 (= Q347), S349 (= S348), T352 (= T351), S401 (= S399), K485 (= K484), E488 (= E487)
1jxaA Glucosamine 6-phosphate synthase with glucose 6-phosphate (see paper)
52% identity, 100% coverage: 2:608/608 of query aligns to 1:608/608 of 1jxaA
- active site: C1 (= C2), R26 (= R27), G27 (= G28), W74 (= W74), N98 (= N98), G99 (= G99), Y248 (≠ H249), E481 (= E480), K485 (= K484), E488 (= E487), H504 (= H503), K603 (= K603)
- binding glucose-6-phosphate: T302 (= T301), S303 (= S302), S347 (= S346), Q348 (= Q347), S349 (= S348), T352 (= T351), S401 (= S399), K485 (= K484), E488 (= E487)
6r4eA Crystal structure of human gfat-1 in complex with glucose-6-phosphate and l-glu (see paper)
37% identity, 100% coverage: 2:608/608 of query aligns to 1:663/663 of 6r4eA
- active site: L7 (= L8), R32 (= R27), W95 (= W74), N122 (= N98), G123 (= G99), E536 (= E480), K540 (= K484), E543 (= E487), H559 (= H503), K658 (= K603)
- binding glucose-6-phosphate: T358 (= T301), S359 (= S302), S403 (= S346), Q404 (= Q347), S405 (= S348), T408 (= T351), S456 (= S399), K540 (= K484), E543 (= E487)
- binding glutamic acid: C1 (= C2), R94 (= R73), W95 (= W74), T97 (= T76), G123 (= G99), D147 (= D123)
1morA Isomerase domain of glucosamine 6-phosphate synthase complexed with glucose 6-phosphate (see paper)
54% identity, 60% coverage: 245:608/608 of query aligns to 2:366/366 of 1morA
- active site: E239 (= E480), K243 (= K484), E246 (= E487), H262 (= H503), K361 (= K603)
- binding 6-O-phosphono-alpha-D-glucopyranose: T60 (= T301), S105 (= S346), Q106 (= Q347), S107 (= S348), T110 (= T351), V157 (= V397), A360 (= A602), K361 (= K603)
1moqA Isomerase domain of glucosamine 6-phosphate synthase complexed with glucosamine 6-phosphate (see paper)
54% identity, 60% coverage: 245:608/608 of query aligns to 2:366/366 of 1moqA
- active site: E239 (= E480), K243 (= K484), E246 (= E487), H262 (= H503), K361 (= K603)
- binding 2-amino-2-deoxy-6-O-phosphono-alpha-D-glucopyranose: T60 (= T301), S61 (= S302), S105 (= S346), Q106 (= Q347), S107 (= S348), T110 (= T351), V157 (= V397), A360 (= A602), K361 (= K603)
1mosA Isomerase domain of glucosamine 6-phosphate synthase complexed with 2- amino-2-deoxyglucitol 6-phosphate (see paper)
54% identity, 60% coverage: 245:608/608 of query aligns to 3:367/367 of 1mosA
- active site: E240 (= E480), K244 (= K484), E247 (= E487), H263 (= H503), K362 (= K603)
- binding 2-deoxy-2-amino glucitol-6-phosphate: T61 (= T301), S62 (= S302), S106 (= S346), Q107 (= Q347), S108 (= S348), T111 (= T351), K244 (= K484), E247 (= E487)
6svmA Crystal structure of human gfat-1 in complex with glucose-6-phosphate, l-glu, and udp-galnac (see paper)
37% identity, 100% coverage: 2:608/608 of query aligns to 1:660/660 of 6svmA
- active site: L7 (= L8), R32 (= R27), W95 (= W74), N122 (= N98), G123 (= G99), E533 (= E480), K537 (= K484), E540 (= E487), H556 (= H503), K655 (= K603)
- binding glucose-6-phosphate: C353 (= C299), T355 (= T301), S356 (= S302), S400 (= S346), Q401 (= Q347), S402 (= S348), T405 (= T351), S453 (= S399), K537 (= K484), E540 (= E487)
- binding glutamic acid: C1 (= C2), R94 (= R73), W95 (= W74), T97 (= T76), H107 (= H86), G123 (= G99), D147 (= D123)
- binding magnesium ion: S434 (≠ A380), R435 (= R381), T437 (≠ A383)
- binding uridine-diphosphate-n-acetylgalactosamine: Q289 (≠ G238), R322 (≠ Y271), G334 (vs. gap), G424 (≠ V370), T426 (≠ V372), S434 (≠ A380), T437 (≠ A383), C439 (≠ L385), G440 (≠ L386), V441 (≠ L387), H442 (≠ P388)
Q06210 Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1; D-fructose-6-phosphate amidotransferase 1; Glutamine:fructose-6-phosphate amidotransferase 1; GFAT 1; GFAT1; Hexosephosphate aminotransferase 1; EC 2.6.1.16 from Homo sapiens (Human) (see paper)
35% identity, 100% coverage: 1:608/608 of query aligns to 1:699/699 of Q06210