SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing WP_012067303.1 NCBI__GCF_000017145.1:WP_012067303.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 1 hits to proteins with known functional sites (download)

2gtvX Nmr structure of monomeric chorismate mutase from methanococcus jannaschii (see paper)
33% identity, 78% coverage: 8:94/111 of query aligns to 3:93/104 of 2gtvX

query
sites
2gtvX

E

E

E

K

L

L

A

A

S

E

Y

I

R
|
R

Q

K

S

K

I

I

D

D

N

E

I

I

D

D

A

N

A

K

L

I

V

L

H

K

-

A

-

R

-

W

-

P

-

W

-

A

-

E

-

K

M

L

L

I

A

A

E

E

R
|
R

F

N

R

S

C

L

T

A

K

K

A

D

V
|
V

G

A

V

E

L

I

K
|
K

A

N

K

Q

H

L

Q

G

L

I

P

P

P

I

A

N

D
|
D

P

P

A

E

R
|
R

E
|
E

E

K

Y

Y

Q

I

I

Y

E

D

R

R

L

I

R

R

H

K

L

L

A

C

K

K

D

E

A

H

N

N

L

V

D

D

P

E

D

N

F

I

A

G

E

I

K

K

F

-

L

-

N

-

F

-

I

I

I

F

K

Q

E

R

V

L

I

I

R

E

H

H

H
x
N

E

K

A

A

I

L

binding 8-hydroxy-2-oxa-bicyclo[3.3.1]non-6-ene-3,5-dicarboxylic acid: R9 (= R14), R34 (= R31), V41 (= V38), K45 (= K42), D54 (= D51), R57 (= R54), E58 (= E55), N90 (≠ H91)

Sites not aligning to the query:

binding 8-hydroxy-2-oxa-bicyclo[3.3.1]non-6-ene-3,5-dicarboxylic acid: 94

Query Sequence

>WP_012067303.1 NCBI__GCF_000017145.1:WP_012067303.1
MLDPGIKEELASYRQSIDNIDAALVHMLAERFRCTKAVGVLKAKHQLPPADPAREEYQIE
RLRHLAKDANLDPDFAEKFLNFIIKEVIRHHEAIAADCSHSAGNAGNTHSA

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory