Comparing WP_012101348.1 NCBI__GCF_000016505.1:WP_012101348.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
8g3hA Structure of cobalamin-dependent methionine synthase (meth) in a resting state (see paper)
31% identity, 99% coverage: 10:798/801 of query aligns to 9:832/841 of 8g3hA
3bofA Cobalamin-dependent methionine synthase (1-566) from thermotoga maritima complexed with zn2+ and homocysteine (see paper)
37% identity, 68% coverage: 10:557/801 of query aligns to 11:554/560 of 3bofA
1q8jA Cobalamin-dependent methionine synthase (1-566) from thermotoga maritima (cd2+, hcy, methyltetrahydrofolate complex) (see paper)
37% identity, 68% coverage: 10:557/801 of query aligns to 11:554/559 of 1q8jA
P13009 Methionine synthase; 5-methyltetrahydrofolate--homocysteine methyltransferase; Methionine synthase, vitamin-B12-dependent; MS; EC 2.1.1.13 from Escherichia coli (strain K12) (see 5 papers)
28% identity, 99% coverage: 4:794/801 of query aligns to 6:866/1227 of P13009
Sites not aligning to the query:
Q99707 Methionine synthase; MS; 5-methyltetrahydrofolate--homocysteine methyltransferase; Cobalamin-dependent methionine synthase; Vitamin-B12 dependent methionine synthase; EC 2.1.1.13 from Homo sapiens (Human) (see 6 papers)
28% identity, 98% coverage: 4:785/801 of query aligns to 16:877/1265 of Q99707
Sites not aligning to the query:
4cczA Crystal structure of human 5-methyltetrahydrofolate-homocysteine methyltransferase, the homocysteine and folate binding domains
27% identity, 70% coverage: 13:571/801 of query aligns to 13:609/611 of 4cczA
2ycjA Methyltransferase bound with methyltetrahydrofolate (see paper)
39% identity, 28% coverage: 316:540/801 of query aligns to 12:237/271 of 2ycjA
2yciX Methyltransferase native (see paper)
39% identity, 28% coverage: 316:540/801 of query aligns to 12:237/271 of 2yciX
2yckX Methyltransferase bound with tetrahydrofolate (see paper)
39% identity, 28% coverage: 316:540/801 of query aligns to 13:238/272 of 2yckX
4djfA Crystal structure of folate-bound corrinoid iron-sulfur protein (cfesp) in complex with its methyltransferase (metr), co-crystallized with folate and ti(iii) citrate reductant (see paper)
35% identity, 30% coverage: 316:559/801 of query aligns to 3:247/262 of 4djfA
4djeA Crystal structure of folate-bound corrinoid iron-sulfur protein (cfesp) in complex with its methyltransferase (metr), co-crystallized with folate (see paper)
35% identity, 30% coverage: 316:559/801 of query aligns to 3:247/262 of 4djeA
4djdA Crystal structure of folate-free corrinoid iron-sulfur protein (cfesp) in complex with its methyltransferase (metr) (see paper)
35% identity, 30% coverage: 316:559/801 of query aligns to 3:247/262 of 4djdA
2e7fA 5-methyltetrahydrofolate corrinoid/iron sulfur protein methyltransferase complexed with methyltetrahydrofolate to 2.2 angsrom resolution (see paper)
35% identity, 30% coverage: 316:559/801 of query aligns to 3:247/262 of 2e7fA
Q46389 5-methyltetrahydrofolate:corrinoid/iron-sulfur protein co-methyltransferase; 5-methyltetrahydrofolate corrinoid/iron sulfur protein methyltransferase; MeTr; EC 2.1.1.258 from Moorella thermoacetica (Clostridium thermoaceticum) (see 2 papers)
35% identity, 30% coverage: 316:559/801 of query aligns to 3:247/262 of Q46389
4o1eA Structure of a methyltransferase component in complex with mthf involved in o-demethylation (see paper)
34% identity, 32% coverage: 316:571/801 of query aligns to 7:262/271 of 4o1eA
8sseA Methionine synthase, c-terminal fragment, cobalamin and reactivation domains from thermus thermophilus hb8 (see paper)
34% identity, 25% coverage: 595:798/801 of query aligns to 3:206/507 of 8sseA
Sites not aligning to the query:
4o1fA Structure of a methyltransferase component in complex with thf involved in o-demethylation (see paper)
34% identity, 32% coverage: 316:571/801 of query aligns to 4:258/267 of 4o1fA
7xcnP Crystal structure of the mttb-mttc complex at 2.7 a resolution (see paper)
35% identity, 24% coverage: 599:792/801 of query aligns to 11:207/215 of 7xcnP
5vooA Methionine synthase folate-binding domain with methyltetrahydrofolate from thermus thermophilus hb8 (see paper)
28% identity, 32% coverage: 316:571/801 of query aligns to 4:275/282 of 5vooA
1y80A Structure of a corrinoid (factor iiim)-binding protein from moorella thermoacetica
47% identity, 15% coverage: 681:799/801 of query aligns to 5:125/125 of 1y80A
>WP_012101348.1 NCBI__GCF_000016505.1:WP_012101348.1
MNFKNLVDKFNNRFIFFDGAMGTMLQKAGLKLGELPEVLNITNPEIISGIHRKYLDAGAD
IITTNTFGANELKYDSSDYTIEDVISAGVKLAKQEAGDKLVALDIGPIGKIMEPTGNLSF
ESAYKLFKNQIVIGEKSGADVVLIETMTDLYEAKAAVLAAKENSNIPIFCTMTFQEDGRT
LMGTDAKTMVFVLEALGVDVLGVNCSLGPKELQGIVEEILKYSSIPVMVQPNAGLPRYDG
ENTIYDISPEDFAENVLTMAQKGIRVLGGCCGTTPEFIRMCRKDLEGLTPLNIEEKHYTA
VCSATDTVIVGEKIKIIGERINPTGRSIYKKELKEGSINYIQKEAIMQKEEGANILGVNV
GLPEINEVEIMKKAIRAVQKVVQLPLSIDSPDPQVLETGIRMYNGKPVINSVNGSKKSME
EVFPIVKKYGGCVIALTIDEKGIPHTAEGRVKIAEKIIKTASIYGINKKNIIIDCLTLTV
SAQQKEVLETIKAIKMVTEKFGVKTVLGVSNISFGLPNRSILNRTFLAMALQAGLNLPIM
NPADESMKEVIAAFQVLTNIDKEGKEYVIKYGNKSKDEKPKGEGNSPLKNADNNLKDLKQ
LIIDGIEDEAEAMTTELLKNKKALEIVNSYIIPALDEVGKQYELQDIFLPQLIQSAETVK
KSFEIIKDNMLSSGQKSLEKGTIVLATVKGDIHDIGKNIVKVLLENYGFEVIDLGRDVDI
DNIVNTIRDNNIKLVGLSALMTTTVASMKKTIEAIRENNLNCKIVVGGAVLNQNYADMIG
ADYYAKDAREAVKIAEEVFLI
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory