SitesBLAST
Comparing WP_012103339.1 NCBI__GCF_000016505.1:WP_012103339.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 18 hits to proteins with known functional sites (download)
5exeC Crystal structure of oxalate oxidoreductase from moorella thermoacetica bound with carboxy-tpp adduct (see paper)
37% identity, 93% coverage: 13:300/310 of query aligns to 15:299/314 of 5exeC
- active site: N143 (= N142)
- binding [2-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-2-carboxy-4-methyl-1,3-thiazol-3-ium-5-yl]ethoxy-oxidanyl-phosphoryl] hydrogen phosphate: T50 (= T50), G51 (= G51), C52 (= C52), I74 (≠ F74), G109 (= G108), D110 (= D109), G111 (= G110), Y136 (= Y135), N138 (= N137), S140 (≠ A139), Y141 (= Y140), A142 (≠ M141), N143 (= N142), T144 (= T143)
- binding magnesium ion: D110 (= D109), D130 (= D129), N138 (= N137), S140 (≠ A139), L211 (≠ I208), Q213 (≠ K210)
- binding iron/sulfur cluster: C24 (= C22), C27 (= C25), P29 (≠ A27), C52 (= C52), C225 (= C222), P226 (= P223), K227 (≠ R224)
5c4iC Structure of an oxalate oxidoreductase (see paper)
37% identity, 93% coverage: 13:300/310 of query aligns to 15:299/312 of 5c4iC
- active site: N143 (= N142)
- binding magnesium ion: D110 (= D109), N138 (= N137), S140 (≠ A139)
- binding iron/sulfur cluster: C24 (= C22), C27 (= C25), P29 (≠ A27), C52 (= C52), A142 (≠ M141), C225 (= C222), P226 (= P223), K227 (≠ R224)
- binding thiamine diphosphate: T50 (= T50), G51 (= G51), C52 (= C52), I74 (≠ F74), G109 (= G108), D110 (= D109), G111 (= G110), Y136 (= Y135), N138 (= N137), S140 (≠ A139), Y141 (= Y140), A142 (≠ M141), N143 (= N142), T144 (= T143)
5exdF Crystal structure of oxalate oxidoreductase from moorella thermoacetica bound with carboxy-di-oxido-methyl-tpp (coom-tpp) intermediate (see paper)
37% identity, 93% coverage: 13:300/310 of query aligns to 15:299/310 of 5exdF
- active site: N143 (= N142)
- binding magnesium ion: D110 (= D109), N138 (= N137), S140 (≠ A139)
- binding [2-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-4-methyl-2-[1,1,2-tris(oxidanyl)-2-oxidanylidene-ethyl]-1,3-thiazol-3-ium-5-yl]ethoxy-oxidanyl-phosphoryl] hydrogen phosphate: T50 (= T50), G51 (= G51), C52 (= C52), I74 (≠ F74), D110 (= D109), G111 (= G110), Y136 (= Y135), N138 (= N137), S140 (≠ A139), Y141 (= Y140), A142 (≠ M141), N143 (= N142), T144 (= T143)
- binding iron/sulfur cluster: C24 (= C22), C27 (= C25), P29 (≠ A27), C52 (= C52), A142 (≠ M141), C225 (= C222), K227 (≠ R224)
2c3uA Crystal structure of pyruvate-ferredoxin oxidoreductase from desulfovibrio africanus, oxygen inhibited form (see paper)
27% identity, 64% coverage: 106:304/310 of query aligns to 959:1162/1231 of 2c3uA
- active site: N995 (= N142)
- binding 2-(3-{[4-(hydroxyamino)-2-methylpyrimidin-5-yl]methyl}-4-methyl-2,3-dihydro-1,3-thiazol-5-yl)ethyl trihydrogen diphosphate: G961 (= G108), D962 (= D109), G963 (= G110), W964 (≠ G111), V992 (≠ A139), Y993 (= Y140), S994 (≠ M141), N995 (= N142), T996 (= T143)
- binding calcium ion: D982 (= D129), N984 (≠ V131), A1055 (= A207), E1056 (≠ I208), F1058 (≠ K210), G1060 (= G212), S1062 (≠ A214)
- binding magnesium ion: D962 (= D109), T990 (≠ N137), V992 (≠ A139)
- binding pyruvic acid: N995 (= N142)
- binding iron/sulfur cluster: C1070 (= C222), I1071 (vs. gap)
Sites not aligning to the query:
- active site: 30, 63, 113
- binding 2-(3-{[4-(hydroxyamino)-2-methylpyrimidin-5-yl]methyl}-4-methyl-2,3-dihydro-1,3-thiazol-5-yl)ethyl trihydrogen diphosphate: 28, 29, 63, 87, 816, 837, 839, 868, 869
- binding pyruvic acid: 30, 113, 122
- binding iron/sulfur cluster: 458, 681, 683, 688, 689, 691, 692, 694, 698, 699, 702, 703, 744, 745, 746, 747, 748, 750, 754, 755, 760, 761, 811, 814, 816, 839
2c3pA Crystal structure of the free radical intermediate of pyruvate:ferredoxin oxidoreductase from desulfovibrio africanus (see paper)
27% identity, 64% coverage: 106:304/310 of query aligns to 959:1162/1231 of 2c3pA
- active site: N995 (= N142)
- binding 1-(2-{(2s,4r,5r)-3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-[(1s)-1-carboxy-1-hydroxyethyl]-4-methyl-1,3-thiazolidin-5-yl}ethoxy)-1,1,3,3-tetrahydroxy-1lambda~5~-diphosphox-1-en-2-ium 3-oxide: G961 (= G108), D962 (= D109), G963 (= G110), V992 (≠ A139), Y993 (= Y140), S994 (≠ M141), N995 (= N142), T996 (= T143)
- binding calcium ion: D982 (= D129), V983 (≠ M130), N984 (≠ V131), A1055 (= A207), E1056 (≠ I208), F1058 (≠ K210), G1060 (= G212), S1062 (≠ A214)
- binding magnesium ion: D962 (= D109), T990 (≠ N137), V992 (≠ A139)
- binding iron/sulfur cluster: S994 (≠ M141), C1070 (= C222), I1071 (vs. gap)
Sites not aligning to the query:
- active site: 30, 63, 113
- binding 1-(2-{(2s,4r,5r)-3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-[(1s)-1-carboxy-1-hydroxyethyl]-4-methyl-1,3-thiazolidin-5-yl}ethoxy)-1,1,3,3-tetrahydroxy-1lambda~5~-diphosphox-1-en-2-ium 3-oxide: 28, 29, 30, 63, 87, 113, 816, 837, 838, 839, 868, 869
- binding iron/sulfur cluster: 458, 681, 683, 688, 689, 690, 691, 692, 694, 698, 699, 702, 703, 744, 745, 746, 747, 748, 750, 754, 755, 760, 761, 810, 811, 814, 816, 839
2c3oA Crystal structure of the free radical intermediate of pyruvate:ferredoxin oxidoreductase from desulfovibrio africanus (see paper)
27% identity, 64% coverage: 106:304/310 of query aligns to 959:1162/1231 of 2c3oA
- active site: N995 (= N142)
- binding calcium ion: D982 (= D129), N984 (≠ V131), E1056 (≠ I208), F1058 (≠ K210), G1060 (= G212)
- binding magnesium ion: D962 (= D109), T990 (≠ N137), V992 (≠ A139)
- binding pyruvic acid: T996 (= T143)
- binding iron/sulfur cluster: C1070 (= C222), I1071 (vs. gap)
- binding thiamine diphosphate: G961 (= G108), D962 (= D109), G963 (= G110), V992 (≠ A139), Y993 (= Y140), S994 (≠ M141), N995 (= N142), T996 (= T143)
Sites not aligning to the query:
- active site: 30, 63, 113
- binding pyruvic acid: 30, 113
- binding iron/sulfur cluster: 458, 681, 688, 689, 691, 692, 694, 698, 699, 702, 703, 744, 746, 747, 748, 749, 750, 754, 760, 761, 810, 811, 814, 816, 839
- binding thiamine diphosphate: 28, 29, 63, 87, 816, 837, 838, 839, 868
1kekA Crystal structure of the free radical intermediate of pyruvate:ferredoxin oxidoreductase (see paper)
27% identity, 64% coverage: 106:304/310 of query aligns to 959:1162/1231 of 1kekA
- active site: N995 (= N142)
- binding calcium ion: D982 (= D129), N984 (≠ V131), A1055 (= A207), E1056 (≠ I208), F1058 (≠ K210), S1062 (≠ A214)
- binding 2-acetyl-thiamine diphosphate: G961 (= G108), D962 (= D109), G963 (= G110), V992 (≠ A139), Y993 (= Y140), S994 (≠ M141), N995 (= N142), T996 (= T143)
- binding magnesium ion: D962 (= D109), T990 (≠ N137), V992 (≠ A139)
- binding iron/sulfur cluster: C1070 (= C222), I1071 (vs. gap)
Sites not aligning to the query:
- active site: 30, 63, 113
- binding 2-acetyl-thiamine diphosphate: 29, 63, 87, 113, 816, 837, 838, 839, 868
- binding iron/sulfur cluster: 458, 681, 683, 688, 689, 690, 691, 692, 694, 698, 699, 703, 737, 744, 745, 746, 747, 748, 750, 754, 755, 760, 761, 810, 811, 814, 816, 839
1b0pA Crystal structure of pyruvate-ferredoxin oxidoreductase from desulfovibrio africanus (see paper)
27% identity, 64% coverage: 106:304/310 of query aligns to 959:1162/1231 of 1b0pA
- active site: N995 (= N142)
- binding calcium ion: D982 (= D129), N984 (≠ V131), A1055 (= A207), E1056 (≠ I208), F1058 (≠ K210), G1060 (= G212)
- binding magnesium ion: D962 (= D109), T990 (≠ N137), V992 (≠ A139)
- binding iron/sulfur cluster: S994 (≠ M141), C1070 (= C222), I1071 (vs. gap)
- binding thiamine diphosphate: G961 (= G108), D962 (= D109), G963 (= G110), V992 (≠ A139), Y993 (= Y140), S994 (≠ M141), N995 (= N142), T996 (= T143)
Sites not aligning to the query:
- active site: 30, 63, 113
- binding iron/sulfur cluster: 458, 681, 683, 688, 689, 690, 691, 692, 694, 698, 699, 702, 703, 737, 744, 745, 747, 748, 750, 754, 755, 760, 811, 814, 816, 839
- binding thiamine diphosphate: 28, 29, 63, 816, 837, 838, 839, 868
P94692 Pyruvate:ferredoxin oxidoreductase; PFOR; POR; Pyruvate synthase; EC 1.2.7.1 from Desulfocurvibacter africanus (Desulfovibrio africanus) (see 3 papers)
27% identity, 64% coverage: 106:304/310 of query aligns to 960:1163/1232 of P94692
- GDGW 962:965 (≠ GDGG 108:111) binding thiamine diphosphate
- D963 (= D109) binding Mg(2+)
- D983 (= D129) binding Ca(2+)
- N985 (≠ V131) binding Ca(2+)
- T991 (≠ N137) binding Mg(2+)
- TEVYSN 991:996 (≠ NGAYMN 137:142) binding thiamine diphosphate
- V993 (≠ A139) binding Mg(2+)
- A1056 (= A207) binding Ca(2+)
- F1059 (≠ K210) binding Ca(2+)
- G1061 (= G212) binding Ca(2+)
- S1063 (≠ A214) binding Ca(2+)
- C1071 (= C222) binding [4Fe-4S] cluster
Sites not aligning to the query:
- 31 binding pyruvate
- 64 binding thiamine diphosphate
- 114 binding pyruvate
- 689 binding [4Fe-4S] cluster
- 692 binding [4Fe-4S] cluster
- 695 binding [4Fe-4S] cluster
- 699 binding [4Fe-4S] cluster
- 745 binding [4Fe-4S] cluster
- 748 binding [4Fe-4S] cluster
- 751 binding [4Fe-4S] cluster
- 755 binding [4Fe-4S] cluster
- 812 binding [4Fe-4S] cluster
- 815 binding [4Fe-4S] cluster
- 817 binding thiamine diphosphate
- 840 binding [4Fe-4S] cluster; binding thiamine diphosphate
7plmA Cryoem reconstruction of pyruvate ferredoxin oxidoreductase (pfor) in anaerobic conditions (see paper)
27% identity, 64% coverage: 106:304/310 of query aligns to 927:1124/1177 of 7plmA
- binding calcium ion: D950 (= D129), N952 (≠ V131), F1026 (≠ K210), G1028 (= G212)
- binding magnesium ion: D930 (= D109), T958 (≠ N137), V960 (≠ A139), S962 (≠ M141)
- binding iron/sulfur cluster: S962 (≠ M141), C1038 (= C222), I1039 (vs. gap)
- binding thiamine diphosphate: G929 (= G108), D930 (= D109), G931 (= G110), V960 (≠ A139), Y961 (= Y140), S962 (≠ M141), N963 (= N142), T964 (= T143)
Sites not aligning to the query:
- binding iron/sulfur cluster: 458, 657, 659, 664, 665, 666, 667, 668, 670, 674, 675, 679, 708, 715, 716, 717, 718, 719, 721, 725, 726, 731, 732, 781, 782, 785, 787, 810
- binding thiamine diphosphate: 27, 28, 29, 63, 787, 808, 809, 810, 839
6n2oD 2-oxoglutarate:ferredoxin oxidoreductase from magnetococcus marinus with 2-oxoglutarate, coenzyme a and succinyl-coa bound (see paper)
30% identity, 68% coverage: 22:233/310 of query aligns to 25:219/291 of 6n2oD
- binding magnesium ion: D101 (= D109), N129 (= N137), I131 (≠ A139)
- binding succinyl-coenzyme a: I57 (≠ T50), R62 (≠ F58), L134 (≠ N142), K136 (≠ G144)
- binding iron/sulfur cluster: C25 (= C22), C28 (= C25), C59 (= C52), C208 (= C222), T210 (≠ R224), F211 (≠ G225)
- binding thiamine diphosphate: I57 (≠ T50), G58 (= G51), C59 (= C52), S60 (= S56), H76 (≠ F74), G102 (= G110), D103 (≠ G111), N129 (= N137), I131 (≠ A139), G133 (≠ M141), L134 (≠ N142), T135 (= T143)
Sites not aligning to the query:
6n2oB 2-oxoglutarate:ferredoxin oxidoreductase from magnetococcus marinus with 2-oxoglutarate, coenzyme a and succinyl-coa bound (see paper)
30% identity, 68% coverage: 22:233/310 of query aligns to 25:219/291 of 6n2oB
- binding 2-oxoglutaric acid: R62 (≠ F58), L134 (≠ N142)
- binding coenzyme a: K136 (≠ G144), Y150 (≠ T158)
- binding magnesium ion: D101 (= D109), N129 (= N137), I131 (≠ A139)
- binding iron/sulfur cluster: C25 (= C22), C28 (= C25), C59 (= C52), C208 (= C222), T210 (≠ R224), F211 (≠ G225)
- binding thiamine diphosphate: I57 (≠ T50), G58 (= G51), C59 (= C52), S60 (= S56), H76 (≠ F74), G102 (= G110), D103 (≠ G111), N129 (= N137), I131 (≠ A139), Y132 (= Y140), G133 (≠ M141), L134 (≠ N142), T135 (= T143)
Sites not aligning to the query:
6n2nB Crystal structure of 2-oxoglutarate:ferredoxin oxidoreductase from magnetococcus marinus (see paper)
30% identity, 68% coverage: 22:233/310 of query aligns to 25:219/291 of 6n2nB
- binding magnesium ion: D101 (= D109), N129 (= N137), I131 (≠ A139)
- binding iron/sulfur cluster: C25 (= C22), C28 (= C25), H30 (≠ A27), C59 (= C52), C208 (= C222), T210 (≠ R224), F211 (≠ G225)
- binding thiamine diphosphate: I57 (≠ T50), G58 (= G51), C59 (= C52), S60 (= S56), H76 (≠ F74), G100 (= G108), D101 (= D109), G102 (= G110), D103 (≠ G111), N129 (= N137), I131 (≠ A139), Y132 (= Y140), G133 (≠ M141), L134 (≠ N142), T135 (= T143)
Sites not aligning to the query:
6cipA Pyruvate:ferredoxin oxidoreductase from moorella thermoacetica with acetyl-tpp bound (see paper)
27% identity, 66% coverage: 106:309/310 of query aligns to 963:1165/1165 of 6cipA
Sites not aligning to the query:
- active site: 28, 61, 111
- binding 2-acetyl-thiamine diphosphate: 27, 61, 85, 111, 813, 834, 835, 836, 865
- binding iron/sulfur cluster: 455, 678, 680, 685, 686, 688, 689, 691, 695, 699, 700, 734, 741, 742, 744, 745, 747, 751, 757, 758, 807, 808, 811, 813, 836
Q2RMD6 Pyruvate:ferredoxin oxidoreductase; PFOR; Pyruvate synthase; EC 1.2.7.1 from Moorella thermoacetica (strain ATCC 39073 / JCM 9320) (see paper)
26% identity, 66% coverage: 106:309/310 of query aligns to 964:1170/1171 of Q2RMD6
- D967 (= D109) binding Mg(2+)
- DGW 967:969 (≠ DGG 109:111) binding thiamine diphosphate
- T995 (≠ N137) binding Mg(2+)
- TEVYSN 995:1000 (≠ NGAYMN 137:142) binding thiamine diphosphate
- V997 (≠ A139) binding Mg(2+)
- C1075 (= C222) binding [4Fe-4S] cluster
Sites not aligning to the query:
- 424:428 binding CoA
- 456 binding CoA
- 556 binding CoA
- 598 binding CoA
- 686 binding [4Fe-4S] cluster
- 689 binding [4Fe-4S] cluster
- 692 binding [4Fe-4S] cluster
- 696 binding [4Fe-4S] cluster
- 742 binding [4Fe-4S] cluster
- 745 binding [4Fe-4S] cluster
- 748 binding [4Fe-4S] cluster
- 752 binding [4Fe-4S] cluster
- 809 binding [4Fe-4S] cluster
- 812 binding [4Fe-4S] cluster
- 814 binding thiamine diphosphate
- 837 binding [4Fe-4S] cluster; binding thiamine diphosphate
6ciqA Pyruvate:ferredoxin oxidoreductase from moorella thermoacetica with coenzyme a bound (see paper)
26% identity, 66% coverage: 106:309/310 of query aligns to 963:1169/1169 of 6ciqA
- active site: N999 (= N142)
- binding coenzyme a: N999 (= N142)
- binding magnesium ion: D966 (= D109), T994 (≠ N137), V996 (≠ A139)
- binding iron/sulfur cluster: S998 (≠ M141), C1074 (= C222), I1075 (≠ P223)
- binding thiamine diphosphate: G965 (= G108), D966 (= D109), G967 (= G110), V996 (≠ A139), Y997 (= Y140), S998 (≠ M141), N999 (= N142), T1000 (= T143)
Sites not aligning to the query:
- active site: 28, 61, 111
- binding coenzyme a: 28, 423, 424, 427, 428, 553, 586
- binding iron/sulfur cluster: 678, 680, 685, 686, 688, 689, 691, 695, 696, 700, 734, 741, 742, 743, 744, 745, 747, 751, 757, 807, 808, 811, 813, 836
- binding thiamine diphosphate: 26, 27, 61, 85, 813, 835, 836, 865
6cinB Crystal structure of pyruvate:ferredoxin oxidoreductase from moorella thermoacetica (see paper)
26% identity, 66% coverage: 106:309/310 of query aligns to 963:1169/1169 of 6cinB
- active site: N999 (= N142)
- binding magnesium ion: D966 (= D109), T994 (≠ N137), V996 (≠ A139)
- binding iron/sulfur cluster: S998 (≠ M141), C1074 (= C222), I1075 (≠ P223)
- binding thiamine diphosphate: G965 (= G108), D966 (= D109), G967 (= G110), V996 (≠ A139), Y997 (= Y140), S998 (≠ M141), N999 (= N142), T1000 (= T143)
Sites not aligning to the query:
- active site: 28, 61, 111
- binding iron/sulfur cluster: 455, 678, 685, 686, 687, 688, 689, 691, 695, 700, 741, 742, 743, 744, 745, 746, 747, 751, 752, 757, 758, 807, 808, 811, 813, 836
- binding thiamine diphosphate: 26, 27, 61, 834, 835, 836, 865
6cioA Pyruvate:ferredoxin oxidoreductase from moorella thermoacetica with lactyl-tpp bound (see paper)
27% identity, 66% coverage: 106:309/310 of query aligns to 963:1164/1164 of 6cioA
- active site: N999 (= N142)
- binding magnesium ion: D966 (= D109), T994 (≠ N137), V996 (≠ A139)
- binding iron/sulfur cluster: C1074 (= C222), I1075 (≠ P223)
- binding 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-(1-carboxy-1-hydroxyethyl)-5-(2-{[hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-4-methyl-1,3-thiazol-3-ium: G965 (= G108), D966 (= D109), G967 (= G110), V996 (≠ A139), Y997 (= Y140), S998 (≠ M141), N999 (= N142), T1000 (= T143)
Sites not aligning to the query:
- active site: 28, 61, 111
- binding iron/sulfur cluster: 455, 678, 680, 685, 686, 688, 689, 691, 695, 699, 700, 734, 741, 742, 744, 745, 747, 751, 757, 758, 807, 808, 811, 813, 836
- binding 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-(1-carboxy-1-hydroxyethyl)-5-(2-{[hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-4-methyl-1,3-thiazol-3-ium: 26, 27, 28, 61, 85, 111, 813, 834, 835, 836, 865
Query Sequence
>WP_012103339.1 NCBI__GCF_000016505.1:WP_012103339.1
MEYKFKEEMNKPERLVGGHRMCAGCGAPIAVRSVLRALGEKDKAVIGSATGCLEVSTFMY
PYTSWKDSFVHSAFECAGATMGGVERAYTALRKRGKIKEDYKFITFGGDGGTYDIGFQSL
SGAMERGHDMVYVCYDNGAYMNTGIQRSSATPKYADTTTTPVGAVSSGKSQFRKNLTEIM
VSHNIPYVAQTTFLGNFKDIHEKAHRAIYKKGPAFLNVLSPCPRGWRYETADLMNICKLA
VDTCFWPIFEVEDGKWKLNYKPKNKLPIEDFLRPQGRFKHLFKKGNEYMIAELQEEIDKR
WETLLKKCEE
Or try a new SitesBLAST search
SitesBLAST's Database
SitesBLAST's database includes
(1) SwissProt
entries with experimentally-supported functional features;
and (2) protein structures with bound ligands, from the
BioLip database.
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory